[ { "uniprot_canonical_ac": "A0AC58JH05-1", "uniprot_id": "A0AC58JH05_DANRE", "mass": 28082.0, "length": 247, "protein_name": "Tumor necrosis factor ligand superfamily member 13 isoform X1", "gene_name": "tnfsf13", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor ligand superfamily member 13 isoform X1", "refseq_ac": "XP_073805761", "gene_names_uniprotkb": "tnfsf13; april", "gene_names_refseq": "april; tnfsf13", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 13 isoform X1", "protein_names_refseq": "tumor necrosis factor ligand superfamily member 13 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JH05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JH30-1", "uniprot_id": "A0AC58JH30_DANRE", "mass": 184883.0, "length": 1649, "protein_name": "Pappalysin-1", "gene_name": "pappaa", "organism": "Zebrafish", "refseq_name": "pregnancy-associated plasma protein A, pappalysin 1a isoform X1", "refseq_ac": "XP_073805791", "gene_names_uniprotkb": "pappaa", "gene_names_refseq": "pappaa", "protein_names_uniprotkb": "Pappalysin-1; 3.4.24.79; Insulin-like growth factor-dependent IGF-binding protein 4 protease; Pregnancy-associated plasma protein A", "protein_names_refseq": "pregnancy-associated plasma protein A, pappalysin 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JH30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JH80-1", "uniprot_id": "A0AC58JH80_DANRE", "mass": 34977.0, "length": 311, "protein_name": "Gap junction protein", "gene_name": "gjb1a", "organism": "Zebrafish", "refseq_name": "connexin 27.5 isoform X1", "refseq_ac": "XP_073805828", "gene_names_uniprotkb": "gjb1a; cx27.5; zfCx27.5", "gene_names_refseq": "cx27.5; gjb1a; zfCx27.5", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "connexin 27.5 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JH80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JH83-1", "uniprot_id": "A0AC58JH83_DANRE", "mass": 70240.0, "length": 609, "protein_name": "Prostaglandin G/H synthase 1", "gene_name": "ptgs1", "organism": "Zebrafish", "refseq_name": "prostaglandin G/H synthase 1 isoform X1", "refseq_ac": "XP_073805847", "gene_names_uniprotkb": "ptgs1; cox1; zCOX-1", "gene_names_refseq": "cox1; ptgs1; zCOX-1", "protein_names_uniprotkb": "Prostaglandin G/H synthase 1; 1.14.99.1; Cyclooxygenase-1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1", "protein_names_refseq": "prostaglandin G/H synthase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.1", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JH83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JH84-1", "uniprot_id": "A0AC58JH84_DANRE", "mass": 233163.0, "length": 2130, "protein_name": "Uncharacterized protein sorbs2a isoform X1", "gene_name": "sorbs2a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein sorbs2a isoform X1", "refseq_ac": "XP_073805841", "gene_names_uniprotkb": "sorbs2a", "gene_names_refseq": "sorbs2a", "protein_names_uniprotkb": "Uncharacterized protein sorbs2a isoform X1", "protein_names_refseq": "uncharacterized protein sorbs2a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JH84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JHF1-1", "uniprot_id": "A0AC58JHF1_DANRE", "mass": 113631.0, "length": 1025, "protein_name": "Glycine cleavage system P protein", "gene_name": "gldc", "organism": "Zebrafish", "refseq_name": "glycine dehydrogenase (decarboxylating), mitochondrial isoform X1", "refseq_ac": "XP_073805910", "gene_names_uniprotkb": "gldc; fb23b05; wu:fb23b05; zgc:66198", "gene_names_refseq": "fb23b05; gldc; wu:fb23b05; zgc:66198", "protein_names_uniprotkb": "Glycine cleavage system P protein; 1.4.4.2", "protein_names_refseq": "glycine dehydrogenase (decarboxylating), mitochondrial isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; The glycine cleavage system catalyzes the degradation of glycine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.4.2", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JHF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JHR6-1", "uniprot_id": "A0AC58JHR6_DANRE", "mass": 50176.0, "length": 439, "protein_name": "Southpaw isoform X1", "gene_name": "spaw", "organism": "Zebrafish", "refseq_name": "southpaw isoform X1", "refseq_ac": "XP_073806025", "gene_names_uniprotkb": "spaw", "gene_names_refseq": "spaw", "protein_names_uniprotkb": "Southpaw isoform X1", "protein_names_refseq": "southpaw isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JHR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JI11-1", "uniprot_id": "A0AC58JI11_DANRE", "mass": 39926.0, "length": 346, "protein_name": "Progestin and adipoQ receptor family member 3a isoform X1", "gene_name": "paqr3a", "organism": "Zebrafish", "refseq_name": "progestin and adipoQ receptor family member 3a isoform X1", "refseq_ac": "XP_073806127", "gene_names_uniprotkb": "paqr3a; paqr3; zgc:73098", "gene_names_refseq": "paqr3a; paqr3; zgc:73098", "protein_names_uniprotkb": "Progestin and adipoQ receptor family member 3a isoform X1", "protein_names_refseq": "progestin and adipoQ receptor family member 3a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15520368;26108469;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0AC58JI11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JI50-1", "uniprot_id": "A0AC58JI50_DANRE", "mass": 134010.0, "length": 1240, "protein_name": "Paxillin", "gene_name": "pxna", "organism": "Zebrafish", "refseq_name": "paxillin a isoform X1", "refseq_ac": "XP_073806159", "gene_names_uniprotkb": "pxna; pxn; wu:fw71f12", "gene_names_refseq": "pxna; pxn; wu:fw71f12", "protein_names_uniprotkb": "Paxillin", "protein_names_refseq": "paxillin a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JI50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JI98-1", "uniprot_id": "A0AC58JI98_DANRE", "mass": 18683.0, "length": 161, "protein_name": "Zinc finger HIT domain-containing protein 1 isoform X1", "gene_name": "znhit1", "organism": "Zebrafish", "refseq_name": "zinc finger HIT domain-containing protein 1 isoform X1", "refseq_ac": "XP_073806217", "gene_names_uniprotkb": "znhit1; zgc:112524", "gene_names_refseq": "zgc:112524; znhit1", "protein_names_uniprotkb": "Zinc finger HIT domain-containing protein 1 isoform X1", "protein_names_refseq": "zinc finger HIT domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JI98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIA8-1", "uniprot_id": "A0AC58JIA8_DANRE", "mass": 69529.0, "length": 603, "protein_name": "Intraflagellar transport protein 74 homolog isoform X1", "gene_name": "ift74", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 74 homolog isoform X1", "refseq_ac": "XP_073806222", "gene_names_uniprotkb": "ift74; zgc:92052", "gene_names_refseq": "ift74; zgc:92052", "protein_names_uniprotkb": "Intraflagellar transport protein 74 homolog isoform X1", "protein_names_refseq": "intraflagellar transport protein 74 homolog isoform X1", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Joubert syndrome (Disease Ontology:DOID:0050777); Bardet-Biedl syndrome 22 (Disease Ontology:DOID:0081011); spermatogenic failure 58 (Disease Ontology:DOID:0112352)", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "26469318;27189481;27486776;32928907;33531668;34502236;36862758", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005929 cilium;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0035845 photoreceptor cell outer segment organization;GO:0007369 gastrulation;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0AC58JIA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIB7-1", "uniprot_id": "A0AC58JIB7_DANRE", "mass": 75299.0, "length": 661, "protein_name": "LIM domain kinase 2", "gene_name": "limk2", "organism": "Zebrafish", "refseq_name": "LIM domain kinase 2 isoform X1", "refseq_ac": "XP_073806231", "gene_names_uniprotkb": "limk2; wu:fa97c09; wu:fk73e11; zgc:91990", "gene_names_refseq": "limk2; wu:fa97c09; wu:fk73e11; zgc:91990", "protein_names_uniprotkb": "LIM domain kinase 2; 2.7.11.1", "protein_names_refseq": "LIM domain kinase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JID0-1", "uniprot_id": "A0AC58JID0_DANRE", "mass": 17242.0, "length": 155, "protein_name": "Activated RNA polymerase II transcriptional coactivator p15", "gene_name": "sub1b", "organism": "Zebrafish", "refseq_name": "SUB1 regulator of transcription b isoform X1", "refseq_ac": "XP_073806229", "gene_names_uniprotkb": "sub1b; rpo2tc1; sub1; zgc:92831", "gene_names_refseq": "rpo2tc1; sub1b; sub1; zgc:92831", "protein_names_uniprotkb": "Activated RNA polymerase II transcriptional coactivator p15; SUB1 homolog", "protein_names_refseq": "SUB1 regulator of transcription b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JID0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIG8-1", "uniprot_id": "A0AC58JIG8_DANRE", "mass": 38106.0, "length": 338, "protein_name": "Uncharacterized protein si:dkey-192k22.2 isoform X1", "gene_name": "si:dkey-192k22.2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-192k22.2 isoform X1", "refseq_ac": "XP_073806281", "gene_names_uniprotkb": "si:dkey-192k22.2", "gene_names_refseq": "si:dkey-192k22.2", "protein_names_uniprotkb": "Uncharacterized protein si:dkey-192k22.2 isoform X1", "protein_names_refseq": "uncharacterized protein si:dkey-192k22.2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIH5-1", "uniprot_id": "A0AC58JIH5_DANRE", "mass": 34583.0, "length": 313, "protein_name": "Zeta-sarcoglycan isoform X1", "gene_name": "sgcz", "organism": "Zebrafish", "refseq_name": "zeta-sarcoglycan isoform X1", "refseq_ac": "XP_073806288", "gene_names_uniprotkb": "sgcz", "gene_names_refseq": "sgcz", "protein_names_uniprotkb": "Zeta-sarcoglycan isoform X1", "protein_names_refseq": "zeta-sarcoglycan isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIJ7-1", "uniprot_id": "A0AC58JIJ7_DANRE", "mass": 66224.0, "length": 581, "protein_name": "Thyroid hormone receptor interactor 10b isoform X1", "gene_name": "trip10b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "trip10b; zgc:56292", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroid hormone receptor interactor 10b isoform X1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIU8-1", "uniprot_id": "A0AC58JIU8_DANRE", "mass": 70533.0, "length": 643, "protein_name": "Far upstream element-binding protein 3 isoform X1", "gene_name": "fubp3", "organism": "Zebrafish", "refseq_name": "far upstream element-binding protein 3 isoform X1", "refseq_ac": "XP_073806410", "gene_names_uniprotkb": "fubp3; zgc:101598", "gene_names_refseq": "fubp3; zgc:101598", "protein_names_uniprotkb": "Far upstream element-binding protein 3 isoform X1", "protein_names_refseq": "far upstream element-binding protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIV0-1", "uniprot_id": "A0AC58JIV0_DANRE", "mass": 59557.0, "length": 530, "protein_name": "Dipeptidyl peptidase 2", "gene_name": "dpp7", "organism": "Zebrafish", "refseq_name": "dipeptidyl peptidase 2 isoform X1", "refseq_ac": "XP_073806417", "gene_names_uniprotkb": "dpp7; wu:fb19g02; zgc:112274; zgc:113564", "gene_names_refseq": "dpp7; wu:fb19g02; zgc:112274; zgc:113564", "protein_names_uniprotkb": "Dipeptidyl peptidase 2; 3.4.14.2; Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; Quiescent cell proline dipeptidase", "protein_names_refseq": "dipeptidyl peptidase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays an important role in the degradation of some oligopeptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JIZ5-1", "uniprot_id": "A0AC58JIZ5_DANRE", "mass": 86425.0, "length": 772, "protein_name": "Major facilitator superfamily domain-containing protein 10 isoform X1", "gene_name": "mfsd10", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mfsd10; zgc:112042", "gene_names_refseq": "", "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 10 isoform X1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JIZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JJB0-1", "uniprot_id": "A0AC58JJB0_DANRE", "mass": 84456.0, "length": 750, "protein_name": "Tubulin polyglutamylase TTLL11 isoform X1", "gene_name": "ttll11", "organism": "Zebrafish", "refseq_name": "tubulin polyglutamylase TTLL11 isoform 2", "refseq_ac": "NP_001093548", "gene_names_uniprotkb": "ttll11; zgc:153539", "gene_names_refseq": "ttll11; zgc:153539", "protein_names_uniprotkb": "Tubulin polyglutamylase TTLL11 isoform X1", "protein_names_refseq": "tubulin polyglutamylase TTLL11 isoform 2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.2986209.1, SRR32588718.809374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719, SAMN18715721 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Sep 22, 2025 this sequence version replaced NP_001093548.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JJB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JJD6-1", "uniprot_id": "A0AC58JJD6_DANRE", "mass": 99858.0, "length": 911, "protein_name": "3-hydroxy-3-methylglutaryl coenzyme A reductase", "gene_name": "hmgcra", "organism": "Zebrafish", "refseq_name": "3-hydroxy-3-methylglutaryl-CoA reductase a isoform X1", "refseq_ac": "XP_073806595", "gene_names_uniprotkb": "hmgcra; hmgcr1a; hmgcr1; si:ch211-129a6.5; zgc:136576", "gene_names_refseq": "hmgcr1a; hmgcr1; hmgcra; si:ch211-129a6.5; zgc:136576", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl coenzyme A reductase; 1.1.1.34; HMG-CoA reductase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-CoA reductase a isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JJE8", "ec_number_list": "1.1.1.34", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JJD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JJQ0-1", "uniprot_id": "A0AC58JJQ0_DANRE", "mass": 94302.0, "length": 842, "protein_name": "Methyltransferase NSUN7", "gene_name": "LOC101882573", "organism": "Zebrafish", "refseq_name": "putative methyltransferase NSUN7", "refseq_ac": "XP_073806703", "gene_names_uniprotkb": "LOC101882573", "gene_names_refseq": "LOC101882573", "protein_names_uniprotkb": "Methyltransferase NSUN7", "protein_names_refseq": "putative methyltransferase NSUN7", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JJQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JJS7-1", "uniprot_id": "A0AC58JJS7_DANRE", "mass": 89548.0, "length": 818, "protein_name": "Neurotrypsin", "gene_name": "prss12", "organism": "Zebrafish", "refseq_name": "neurotrypsin isoform X1", "refseq_ac": "XP_073806743", "gene_names_uniprotkb": "prss12", "gene_names_refseq": "prss12", "protein_names_uniprotkb": "Neurotrypsin; Serine protease 12", "protein_names_refseq": "neurotrypsin isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JJS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JJU3-1", "uniprot_id": "A0AC58JJU3_DANRE", "mass": 54930.0, "length": 489, "protein_name": "Opsin 4xb isoform X1", "gene_name": "opn4xb", "organism": "Zebrafish", "refseq_name": "opsin 4xb isoform X1", "refseq_ac": "XP_073806758", "gene_names_uniprotkb": "opn4xb; opn4x1; opn4x2; si:dkeyp-100d11.3", "gene_names_refseq": "opn4x1; opn4x2; opn4xb; si:dkeyp-100d11.3", "protein_names_uniprotkb": "Opsin 4xb isoform X1", "protein_names_refseq": "opsin 4xb isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Photoreceptor implicated in non-image-forming responses to light., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JJU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JK68-1", "uniprot_id": "A0AC58JK68_DANRE", "mass": 474845.0, "length": 4163, "protein_name": "Dynein axonemal heavy chain 6", "gene_name": "dnah6", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 6", "refseq_ac": "XP_073806886", "gene_names_uniprotkb": "dnah6", "gene_names_refseq": "dnah6", "protein_names_uniprotkb": "Dynein axonemal heavy chain 6", "protein_names_refseq": "dynein axonemal heavy chain 6", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JK68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLZ9-1", "uniprot_id": "A0AC58JLZ9_DANRE", "mass": 25830.0, "length": 231, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC101884613", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807488", "gene_names_uniprotkb": "LOC101884613", "gene_names_refseq": "LOC101884613", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKB0-1", "uniprot_id": "A0AC58JKB0_DANRE", "mass": 24854.0, "length": 226, "protein_name": "ADP-ribosylation factor-like protein 15", "gene_name": "arl15a", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor-like protein 15a isoform X1", "refseq_ac": "XP_073806918", "gene_names_uniprotkb": "arl15a; arl15", "gene_names_refseq": "arl15a; arl15", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 15", "protein_names_refseq": "ADP-ribosylation factor-like protein 15a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567657)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29093028", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM35-1", "uniprot_id": "A0AC58JM35_DANRE", "mass": 62628.0, "length": 552, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC101885607", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807526", "gene_names_uniprotkb": "LOC101885607", "gene_names_refseq": "LOC101885607", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885607)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JNI3-1", "uniprot_id": "A0AC58JNI3_DANRE", "mass": 35435.0, "length": 306, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC100002472", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073808046", "gene_names_uniprotkb": "LOC100002472", "gene_names_refseq": "LOC100002472", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002472)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JNI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JL89-1", "uniprot_id": "A0AC58JL89_DANRE", "mass": 28029.0, "length": 242, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC100150003", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807251", "gene_names_uniprotkb": "LOC100150003", "gene_names_refseq": "LOC100150003", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100150003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JL89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JNC1-1", "uniprot_id": "A0AC58JNC1_DANRE", "mass": 29754.0, "length": 260, "protein_name": "Uncharacterized protein CXorf58 homolog isoform X1", "gene_name": "gb:ee300746", "organism": "Zebrafish", "refseq_name": "uncharacterized protein CXorf58 homolog isoform X1", "refseq_ac": "XP_073807967", "gene_names_uniprotkb": "gb:ee300746", "gene_names_refseq": "gb:ee300746", "protein_names_uniprotkb": "Uncharacterized protein CXorf58 homolog isoform X1", "protein_names_refseq": "uncharacterized protein CXorf58 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:797675)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JNC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JMD1-1", "uniprot_id": "A0AC58JMD1_DANRE", "mass": 99382.0, "length": 891, "protein_name": "Uncharacterized protein znf541 isoform X1", "gene_name": "znf541", "organism": "Zebrafish", "refseq_name": "uncharacterized protein znf541 isoform X1", "refseq_ac": "XP_073807639", "gene_names_uniprotkb": "znf541", "gene_names_refseq": "znf541", "protein_names_uniprotkb": "Uncharacterized protein znf541 isoform X1", "protein_names_refseq": "uncharacterized protein znf541 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100003346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0042470 melanosome;GO:0010008 endosome membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0AC58JL54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKM6-1", "uniprot_id": "A0AC58JKM6_DANRE", "mass": 102836.0, "length": 931, "protein_name": "Sodium/calcium exchanger 2a isoform X1", "gene_name": "slc8a2a", "organism": "Zebrafish", "refseq_name": "sodium/calcium exchanger 2a isoform X1", "refseq_ac": "XP_073807039", "gene_names_uniprotkb": "slc8a2a; si:dkey-85k8.4", "gene_names_refseq": "si:dkey-85k8.4; slc8a2a", "protein_names_uniprotkb": "Sodium/calcium exchanger 2a isoform X1", "protein_names_refseq": "sodium/calcium exchanger 2a isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0098794 postsynapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0007154 cell communication;GO:0006874 intracellular calcium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:1990034 calcium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM51-1", "uniprot_id": "A0AC58JM51_DANRE", "mass": 284341.0, "length": 2592, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mast4", "organism": "Zebrafish", "refseq_name": "microtubule-associated serine/threonine-protein kinase 4 isoform X1", "refseq_ac": "XP_073807559", "gene_names_uniprotkb": "mast4", "gene_names_refseq": "mast4", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100149322)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLE7-1", "uniprot_id": "A0AC58JLE7_DANRE", "mass": 29583.0, "length": 256, "protein_name": "Uncharacterized protein si:dkey-58f10.14 isoform X1", "gene_name": "si:dkey-58f10.14", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-58f10.14 isoform X1", "refseq_ac": "XP_073807271", "gene_names_uniprotkb": "si:dkey-58f10.14", "gene_names_refseq": "si:dkey-58f10.14", "protein_names_uniprotkb": "Uncharacterized protein si:dkey-58f10.14 isoform X1", "protein_names_refseq": "uncharacterized protein si:dkey-58f10.14 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100317041)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JN58-1", "uniprot_id": "A0AC58JN58_DANRE", "mass": 24198.0, "length": 212, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC110439787", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807909", "gene_names_uniprotkb": "LOC110439787", "gene_names_refseq": "LOC110439787", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:110439787)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0AC58JKT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLF9-1", "uniprot_id": "A0AC58JLF9_DANRE", "mass": 42991.0, "length": 386, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC137490152", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807322", "gene_names_uniprotkb": "LOC137490152", "gene_names_refseq": "LOC137490152", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:137490152)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKQ2-1", "uniprot_id": "A0AC58JKQ2_DANRE", "mass": 29285.0, "length": 241, "protein_name": "Uncharacterized protein isoform X2", "gene_name": "LOC108190615", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X2", "refseq_ac": "XP_073807063", "gene_names_uniprotkb": "LOC108190615", "gene_names_refseq": "LOC108190615", "protein_names_uniprotkb": "Uncharacterized protein isoform X2", "protein_names_refseq": "uncharacterized protein isoform X2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKW3-1", "uniprot_id": "A0AC58JKW3_DANRE", "mass": 25132.0, "length": 219, "protein_name": "Hairy and enhancer of split related-7 isoform X1", "gene_name": "her7", "organism": "Zebrafish", "refseq_name": "hairy and enhancer of split related-7 isoform X1", "refseq_ac": "XP_073807124", "gene_names_uniprotkb": "her7; cb715", "gene_names_refseq": "cb715; her7", "protein_names_uniprotkb": "Hairy and enhancer of split related-7 isoform X1", "protein_names_refseq": "hairy and enhancer of split related-7 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKX9-1", "uniprot_id": "A0AC58JKX9_DANRE", "mass": 69663.0, "length": 620, "protein_name": "Uncharacterized protein C5orf34 homolog isoform X1", "gene_name": "zgc:153352", "organism": "Zebrafish", "refseq_name": "uncharacterized protein C5orf34 homolog isoform X1", "refseq_ac": "XP_073807137", "gene_names_uniprotkb": "zgc:153352; si:dkeyp-118g6.3", "gene_names_refseq": "si:dkeyp-118g6.3; zgc:153352", "protein_names_uniprotkb": "Uncharacterized protein C5orf34 homolog isoform X1", "protein_names_refseq": "uncharacterized protein C5orf34 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JKZ5-1", "uniprot_id": "A0AC58JKZ5_DANRE", "mass": 103649.0, "length": 920, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "zgc:152816", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807163", "gene_names_uniprotkb": "zgc:152816; si:ch211-271b14.1; zgc:92551", "gene_names_refseq": "si:ch211-271b14.1; zgc:152816; zgc:92551", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JKZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JL04-1", "uniprot_id": "A0AC58JL04_DANRE", "mass": 27108.0, "length": 238, "protein_name": "Sperm acrosome-associated protein 9 isoform X1", "gene_name": "spaca9", "organism": "Zebrafish", "refseq_name": "sperm acrosome-associated protein 9 isoform X1", "refseq_ac": "XP_073807169", "gene_names_uniprotkb": "spaca9; si:ch211-215c18.6; zgc:153740", "gene_names_refseq": "si:ch211-215c18.6; spaca9; zgc:153740", "protein_names_uniprotkb": "Sperm acrosome-associated protein 9 isoform X1", "protein_names_refseq": "sperm acrosome-associated protein 9 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JL04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JL22-1", "uniprot_id": "A0AC58JL22_DANRE", "mass": 14257.0, "length": 123, "protein_name": "C-C motif chemokine 19a.1 isoform X2", "gene_name": "ccl19a.1", "organism": "Zebrafish", "refseq_name": "C-C motif chemokine 19a.1 isoform X2", "refseq_ac": "XP_073807184", "gene_names_uniprotkb": "ccl19a.1; ccl-c5a; si:ch211-89f7.4", "gene_names_refseq": "ccl-c5a; ccl19a.1; si:ch211-89f7.4", "protein_names_uniprotkb": "C-C motif chemokine 19a.1 isoform X2", "protein_names_refseq": "C-C motif chemokine 19a.1 isoform X2", "tax_id": 7955, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JL22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLC7-1", "uniprot_id": "A0AC58JLC7_DANRE", "mass": 24699.0, "length": 219, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385561", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807256", "gene_names_uniprotkb": "LOC141385561", "gene_names_refseq": "LOC141385561", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLH0-1", "uniprot_id": "A0AC58JLH0_DANRE", "mass": 37721.0, "length": 343, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC137490154", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like isoform X1", "refseq_ac": "XP_073807318", "gene_names_uniprotkb": "LOC137490154", "gene_names_refseq": "LOC137490154", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLK5-1", "uniprot_id": "A0AC58JLK5_DANRE", "mass": 77282.0, "length": 687, "protein_name": "Polyubiquitin-C", "gene_name": "si:ch211-202a12.4", "organism": "Zebrafish", "refseq_name": "polyubiquitin-B", "refseq_ac": "NP_001410090", "gene_names_uniprotkb": "si:ch211-202a12.4", "gene_names_refseq": "fb13c03; si:ch211-202a12.4; ubc; wu:fb13c03", "protein_names_uniprotkb": "Polyubiquitin-C", "protein_names_refseq": "polyubiquitin-B", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.1059901.1, SRR26395014.737555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Aug 19, 2025 this sequence version replaced XP_073807362.1, NP_001410090.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLK6-1", "uniprot_id": "A0AC58JLK6_DANRE", "mass": 59997.0, "length": 530, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385576", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807364", "gene_names_uniprotkb": "LOC141385576", "gene_names_refseq": "LOC141385576", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLL9-1", "uniprot_id": "A0AC58JLL9_DANRE", "mass": 60048.0, "length": 534, "protein_name": "Polyubiquitin-B", "gene_name": "ubb", "organism": "Zebrafish", "refseq_name": "polyubiquitin-C", "refseq_ac": "NP_001428626", "gene_names_uniprotkb": "ubb", "gene_names_refseq": "Ubi-p63E; im:6892314; si:ch211-202a12.3; ubb; ubc; zUBC; zgc:172187", "protein_names_uniprotkb": "Polyubiquitin-B", "protein_names_refseq": "polyubiquitin-C; ubiquitin C", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.1478358.1, SRR26395015.174751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 27, 2025 this sequence version replaced XP_073807363.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLM3-1", "uniprot_id": "A0AC58JLM3_DANRE", "mass": 99613.0, "length": 870, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC110439824", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807385", "gene_names_uniprotkb": "LOC110439824", "gene_names_refseq": "LOC110439824", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLN1-1", "uniprot_id": "A0AC58JLN1_DANRE", "mass": 96271.0, "length": 841, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100001405", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807394", "gene_names_uniprotkb": "LOC100001405", "gene_names_refseq": "LOC100001405", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JLN6", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLP1-1", "uniprot_id": "A0AC58JLP1_DANRE", "mass": 82545.0, "length": 721, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC137495534", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807405", "gene_names_uniprotkb": "LOC137495534", "gene_names_refseq": "LOC137495534", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLP3-1", "uniprot_id": "A0AC58JLP3_DANRE", "mass": 50257.0, "length": 469, "protein_name": "Sedoheptulokinase", "gene_name": "shpk", "organism": "Zebrafish", "refseq_name": "sedoheptulokinase isoform X1", "refseq_ac": "XP_073807412", "gene_names_uniprotkb": "shpk", "gene_names_refseq": "shpk", "protein_names_uniprotkb": "Sedoheptulokinase; 2.7.1.14; Carbohydrate kinase-like protein", "protein_names_refseq": "sedoheptulokinase isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a modulator of macrophage activation through control of glucose metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JLQ5;A0AC58JLT1", "ec_number_list": "2.7.1.14", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLP5-1", "uniprot_id": "A0AC58JLP5_DANRE", "mass": 71511.0, "length": 625, "protein_name": "General transcription factor II-I repeat domain-containing protein 2-like", "gene_name": "LOC103911107", "organism": "Zebrafish", "refseq_name": "general transcription factor II-I repeat domain-containing protein 2-like", "refseq_ac": "XP_073807411", "gene_names_uniprotkb": "LOC103911107", "gene_names_refseq": "LOC103911107", "protein_names_uniprotkb": "General transcription factor II-I repeat domain-containing protein 2-like", "protein_names_refseq": "general transcription factor II-I repeat domain-containing protein 2-like", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLQ8-1", "uniprot_id": "A0AC58JLQ8_DANRE", "mass": 43202.0, "length": 384, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC137495530", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-3-like isoform X1", "refseq_ac": "XP_073807416", "gene_names_uniprotkb": "LOC137495530; LOC110439820", "gene_names_refseq": "LOC110439820", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-3-like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. 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This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JLU7", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLX0-1", "uniprot_id": "A0AC58JLX0_DANRE", "mass": 64160.0, "length": 587, "protein_name": "Glutathione hydrolase 6", "gene_name": "ggt6", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ggt6", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione hydrolase 6", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLX2-1", "uniprot_id": "A0AC58JLX2_DANRE", "mass": 45796.0, "length": 422, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC137496620", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807482", "gene_names_uniprotkb": "LOC137496620", "gene_names_refseq": "LOC137496620", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JLZ7-1", "uniprot_id": "A0AC58JLZ7_DANRE", "mass": 36333.0, "length": 369, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385601", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807504", "gene_names_uniprotkb": "LOC141385601", "gene_names_refseq": "LOC141385601", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JLZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM29-1", "uniprot_id": "A0AC58JM29_DANRE", "mass": 80949.0, "length": 713, "protein_name": "Alpha-galactosidase MYORG", "gene_name": "si:ch211-117c19.1", "organism": "Zebrafish", "refseq_name": "myogenesis-regulating glycosidase isoform X1", "refseq_ac": "XP_073807532", "gene_names_uniprotkb": "si:ch211-117c19.1", "gene_names_refseq": "si:ch211-117c19.1", "protein_names_uniprotkb": "Alpha-galactosidase MYORG; 3.2.1.22; Myogenesis regulating glycosidase; Nuclear envelope transmembrane protein 37", "protein_names_refseq": "myogenesis-regulating glycosidase isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Alpha-galactosidase with unusual specificity for the Gal-alpha1,4-Glc structure, whose in vivo substrate is still unknown. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM31-1", "uniprot_id": "A0AC58JM31_DANRE", "mass": 47497.0, "length": 419, "protein_name": "G2/M phase-specific E3 ubiquitin-protein ligase-like isoform X1", "gene_name": "LOC137495523", "organism": "Zebrafish", "refseq_name": "G2/M phase-specific E3 ubiquitin-protein ligase-like isoform X1", "refseq_ac": "XP_073807543", "gene_names_uniprotkb": "LOC137495523", "gene_names_refseq": "LOC137495523", "protein_names_uniprotkb": "G2/M phase-specific E3 ubiquitin-protein ligase-like isoform X1", "protein_names_refseq": "G2/M phase-specific E3 ubiquitin-protein ligase-like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM33-1", "uniprot_id": "A0AC58JM33_DANRE", "mass": 103687.0, "length": 982, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385610", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807542", "gene_names_uniprotkb": "LOC141385610", "gene_names_refseq": "LOC141385610", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM37-1", "uniprot_id": "A0AC58JM37_DANRE", "mass": 60597.0, "length": 544, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385612", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807550", "gene_names_uniprotkb": "LOC141385612", "gene_names_refseq": "LOC141385612", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM39-1", "uniprot_id": "A0AC58JM39_DANRE", "mass": 39861.0, "length": 359, "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "LOC141385613", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807552", "gene_names_uniprotkb": "LOC141385613", "gene_names_refseq": "LOC141385613", "protein_names_uniprotkb": "Reverse transcriptase domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM40-1", "uniprot_id": "A0AC58JM40_DANRE", "mass": 40404.0, "length": 359, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385611", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807549", "gene_names_uniprotkb": "LOC141385611", "gene_names_refseq": "LOC141385611", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM43-1", "uniprot_id": "A0AC58JM43_DANRE", "mass": 180911.0, "length": 1603, "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "LOC141385616", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807553", "gene_names_uniprotkb": "LOC141385616", "gene_names_refseq": "LOC141385616", "protein_names_uniprotkb": "Gypsy retrotransposon integrase-like protein 1; 3.1.26.4", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM49-1", "uniprot_id": "A0AC58JM49_DANRE", "mass": 86058.0, "length": 776, "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "LOC141385617", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807554", "gene_names_uniprotkb": "LOC141385617", "gene_names_refseq": "LOC141385617", "protein_names_uniprotkb": "Reverse transcriptase domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM54-1", "uniprot_id": "A0AC58JM54_DANRE", "mass": 50708.0, "length": 449, "protein_name": "Integrase catalytic domain-containing protein", "gene_name": "LOC141385607", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807541", "gene_names_uniprotkb": "LOC141385607", "gene_names_refseq": "LOC141385607", "protein_names_uniprotkb": "Integrase catalytic domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JMA6-1", "uniprot_id": "A0AC58JMA6_DANRE", "mass": 104747.0, "length": 938, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC141385623", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_073807601", "gene_names_uniprotkb": "LOC141385623", "gene_names_refseq": "LOC141385623", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JMA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JM94-1", "uniprot_id": "A0AC58JM94_DANRE", "mass": 54271.0, "length": 487, "protein_name": "Uncharacterized protein", "gene_name": "LOC141385624", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_073807612", "gene_names_uniprotkb": "LOC141385624", "gene_names_refseq": "LOC141385624", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JM94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AC58JMB9-1", "uniprot_id": "A0AC58JMB9_DANRE", "mass": 57390.0, "length": 488, "protein_name": "Coiled-coil domain-containing protein 15", "gene_name": "ccdc15", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 15", "refseq_ac": "NP_001429397", "gene_names_uniprotkb": "ccdc15", "gene_names_refseq": "ccdc15", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 15", "protein_names_refseq": "coiled-coil domain-containing protein 15; unm_sa517", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01017640.1, SRR26395064.673440.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Aug 8, 2025 this sequence version replaced XP_073807624.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AC58JMB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBS6-1", "uniprot_id": "TM258_DANRE", "mass": 9098.0, "length": 79, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "gene_name": "tmem258", "organism": "Zebrafish", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258", "refseq_ac": "NP_957063", "gene_names_uniprotkb": "tmem258; zgc:73269", "gene_names_refseq": "c11orf10; tmem258; zgc:73269", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258; Oligosaccharyl transferase subunit TMEM258; Transmembrane protein 258", "protein_names_refseq": "UPF0197 transmembrane protein C11orf10 homolog; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258; oligosaccharyl transferase subunit TMEM258", "tax_id": 7955, "disease": "", "pathway": " (dre:393742); (R-DRE-9768727)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CF102693.1, GDQH01004304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476769, SAMEA4476780 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1 and EH499479.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0062062 oligosaccharyltransferase complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PBS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBT4-1", "uniprot_id": "Q6PBT4_DANRE", "mass": 41381.0, "length": 368, "protein_name": "Dual specificity protein phosphatase", "gene_name": "dusp5", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase 5", "refseq_ac": "NP_997730", "gene_names_uniprotkb": "dusp5; wu:fc03b11; wu:fc86e02", "gene_names_refseq": "dusp5; wu:fc03b11; wu:fc86e02", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 5", "tax_id": 7955, "disease": "", "pathway": " (dre:114436); (R-DRE-112409); (R-DRE-5675221)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15802528;15827125;15937927;16336046;18927432;28992598;31705559;32208220;32651405;33408418", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059592.1, GDQH01016186.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059592.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1., [UniProtKB, UniProtKB]; Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F6PBQ2;Q1LV11", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PBT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBT7-1", "uniprot_id": "TIM14_DANRE", "mass": 12433.0, "length": 115, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM14", "gene_name": "dnajc19", "organism": "Zebrafish", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM14", "refseq_ac": "NP_957055", "gene_names_uniprotkb": "dnajc19; tim14; timm14; zgc:73251", "gene_names_refseq": "dnajc19; zgc:73251", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM14; DnaJ homolog subfamily C member 19", "protein_names_refseq": "dnaJ homolog subfamily C member 19; mitochondrial import inner membrane translocase subunit TIM14", "tax_id": 7955, "disease": "3-methylglutaconic aciduria type 5 (Disease Ontology:DOID:0110000)", "pathway": " (dre:393734)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH540082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059589.1., [RefSeq]; Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0099617 matrix side of mitochondrial inner membrane;GO:0001405 PAM complex, Tim23 associated import motor;GO:0098800 inner mitochondrial membrane protein complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix;GO:1900208 regulation of cardiolipin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PBT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBU7-1", "uniprot_id": "UQCC2_DANRE", "mass": 15021.0, "length": 129, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 2", "gene_name": "uqcc2", "organism": "Zebrafish", "refseq_name": "ubiquinol-cytochrome-c reductase complex assembly factor 2", "refseq_ac": "NP_957052", "gene_names_uniprotkb": "uqcc2; mnf1; zgc:73238", "gene_names_refseq": "mnf1; uqcc2; zgc:73238", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 2; Mitochondrial nucleoid factor 1; Mitochondrial protein M19", "protein_names_refseq": "mitochondrial nucleoid factor 1; mitochondrial protein M19; ubiquinol-cytochrome-c reductase complex assembly factor 2", "tax_id": 7955, "disease": "mitochondrial complex III deficiency nuclear type 7 (Disease Ontology:DOID:0080116)", "pathway": " (dre:393731)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH499435.1, EH553142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH499435.1 and BI673784.1., [RefSeq]; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). May play a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production. May be involved in cytochrome b translation and/or stability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0002082 regulation of oxidative phosphorylation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0070131 positive regulation of mitochondrial translation;GO:2001014 regulation of skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PBU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBV6-1", "uniprot_id": "NHP2_DANRE", "mass": 16688.0, "length": 150, "protein_name": "H/ACA ribonucleoprotein complex subunit 2-like protein", "gene_name": "nhp2", "organism": "Zebrafish", "refseq_name": "H/ACA ribonucleoprotein complex subunit 2-like protein", "refseq_ac": "NP_997762", "gene_names_uniprotkb": "nhp2; nola2; zgc:73227", "gene_names_refseq": "nhp2; nola2; wu:fb36b10; wu:fd61a03; zgc:73227", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 2-like protein; Nucleolar protein family A member 2-like protein; snoRNP protein NHP2", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit 2-like protein; nucleolar protein family A member 2-like protein; nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs); snoRNP protein NHP2", "tax_id": 7955, "disease": "autosomal recessive dyskeratosis congenita 2 (Disease Ontology:DOID:0070017)", "pathway": " (dre:100003787); (R-DRE-171319); (R-DRE-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH537394.1, EH543226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH537394.1, EH553640.1, EH557479.1 and EH485076.1. On or before Mar 6, 2008 this sequence version replaced XP_688685.1, XP_001338395.1., [RefSeq]; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding", "go_cellular_component": "GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PBV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBX9-1", "uniprot_id": "REEP5_DANRE", "mass": 21407.0, "length": 189, "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "reep5", "organism": "Zebrafish", "refseq_name": "receptor expression-enhancing protein 5", "refseq_ac": "NP_956352", "gene_names_uniprotkb": "reep5", "gene_names_refseq": "fb02g04; reep5; wu:fb02g04; zgc:73197", "protein_names_uniprotkb": "Receptor expression-enhancing protein 5", "protein_names_refseq": "receptor expression-enhancing protein 5", "tax_id": 7955, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (dre:337237)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;32075961;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH433125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059545.1., [RefSeq]; Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PBX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBY0-1", "uniprot_id": "GNB5B_DANRE", "mass": 43440.0, "length": 395, "protein_name": "Guanine nucleotide-binding protein subunit beta-5b", "gene_name": "gnb5b", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein subunit beta-5b", "refseq_ac": "NP_957040", "gene_names_uniprotkb": "gnb5b", "gene_names_refseq": "gnb5b; gnb5; zgc:73196", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-5b", "protein_names_refseq": "guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide-binding protein subunit beta-5b; guanine nucleotide-binding protein subunit beta-5", "tax_id": 7955, "disease": "Lodder-Merla syndrome type 1 with impaired intellectual development and cardiac arrhythmia (Disease Ontology:DOID:0081008)", "pathway": " (dre:393719)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27523599", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059544.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059544.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5a, plays an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (PubMed:27523599)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Zebrafish gnb5 knockouts recapitulated the phenotypic spectrum of affected individuals, including cardiac, neurological, and ophthalmological abnormalities, supporting a direct role of GNB5 in the control of heart rate, hypotonia, and vision Erratum:[Am J Hum Genet. 2016 Sep 1;99(3):786. doi: 10.1016/j.ajhg.2016.08.011. PMID: 27588455], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007212 G protein-coupled dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PBY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBY1-1", "uniprot_id": "RS3A_DANRE", "mass": 30199.0, "length": 267, "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "rps3a", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein eS1", "refseq_ac": "NP_956353", "gene_names_uniprotkb": "rps3a", "gene_names_refseq": "fb02h01; rpS3Ae; rps3a; wu:fb02h01; zgc:73195; zgc:86672", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1; 40S ribosomal protein S3a", "protein_names_refseq": "ribosomal protein S3Ae; small ribosomal subunit protein eS1", "tax_id": 7955, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (dre:337240); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "15256591;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01002384.1, EH548413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis (By similarity)., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0043009 chordate embryonic development;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PBY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC19-1", "uniprot_id": "SSU72_DANRE", "mass": 22793.0, "length": 194, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "ssu72", "organism": "Zebrafish", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "refseq_ac": "NP_957022", "gene_names_uniprotkb": "ssu72; zgc:73143", "gene_names_refseq": "ssu72; zgc:73143", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72; 3.1.3.16; CTD phosphatase SSU72", "protein_names_refseq": "CTD phosphatase SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72; SSU72 RNA polymerase II CTD phosphatase homolog", "tax_id": 7955, "disease": "liver disease (Disease Ontology:DOID:409)", "pathway": " (dre:393701); (R-DRE-6807505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH492326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476737 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059504.1. On Jul 6, 2005 this sequence version replaced XP_699302.1., [RefSeq]; May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;2.7.7.6;3.1.3.67;3.1.3.27;2.7.4.3;3.1.27.-;2.7.11.22;2.7.11.23", "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PC19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC24-1", "uniprot_id": "YIF1A_DANRE", "mass": 34257.0, "length": 307, "protein_name": "Protein YIF1A", "gene_name": "yif1a", "organism": "Zebrafish", "refseq_name": "protein YIF1A", "refseq_ac": "NP_956225", "gene_names_uniprotkb": "yif1a; zgc:73136", "gene_names_refseq": "fa11c09; fk27h03; wu:fa11c09; wu:fk27h03; yif1a; zgc:73136", "protein_names_uniprotkb": "Protein YIF1A; YIP1-interacting factor homolog A", "protein_names_refseq": "YIP1-interacting factor homolog A; protein YIF1A", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:334982)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059499.1., [RefSeq]; Possible role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZV12", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PC24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC29-1", "uniprot_id": "143G1_DANRE", "mass": 28235.0, "length": 247, "protein_name": "14-3-3 protein gamma-1", "gene_name": "ywhag1", "organism": "Zebrafish", "refseq_name": "14-3-3 protein gamma-1", "refseq_ac": "NP_998187", "gene_names_uniprotkb": "ywhag1; cb47; fd20c02; wu:fd20c02; wu:fj53d01; ywhag; zgc:73131", "gene_names_refseq": "cb47; fd20c02; wu:fd20c02; wu:fj53d01; ywhag1; ywhag; zgc:73131", "protein_names_uniprotkb": "14-3-3 protein gamma-1", "protein_names_refseq": "14-3-3 protein gamma-1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 56 (Disease Ontology:DOID:0080282); intellectual disability (Disease Ontology:DOID:1059); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949)", "pathway": " (dre:117604); (R-DRE-111447); (R-DRE-380320); (R-DRE-5625740); (R-DRE-5628897); (R-DRE-75035); (R-DRE-9614399); (R-DRE-9929491)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "20146355", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01020352.1, SRR32588730.28348576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH437629.1, EF095156.1 and JBMGRA010000005.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner., [UniProtKB, UniProtKB]; When zebrafish ywhag1 was knocked down, reduced brain size and increased diameter of the heart tube were observed, indicating that the infantile spasms and cardiomegaly seen in the patient with the telomeric deletion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0140031 phosphorylation-dependent protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0007507 heart development;GO:0007420 brain development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PC29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC69-1", "uniprot_id": "RL10A_DANRE", "mass": 24622.0, "length": 216, "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "rpl10a", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein uL1", "refseq_ac": "NP_955930", "gene_names_uniprotkb": "rpl10a; wu:fb94f08; zgc:73082; zgc:86881", "gene_names_refseq": "rpl10a; wu:fb94f08; zgc:73082; zgc:86881", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1; 60S ribosomal protein L10a", "protein_names_refseq": "60S ribosomal protein L10a; large ribosomal subunit protein uL1", "tax_id": 7955, "disease": "", "pathway": " (dre:323305); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071510.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059454.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQA0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0033077 T cell differentiation in thymus;GO:0042541 hemoglobin biosynthetic process;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PC69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD82-1", "uniprot_id": "TM129_DANRE", "mass": 41146.0, "length": 361, "protein_name": "E3 ubiquitin-protein ligase TM129", "gene_name": "tmem129", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase TM129", "refseq_ac": "NP_998612", "gene_names_uniprotkb": "tmem129; zgc:63798", "gene_names_refseq": "fc17d07; tmem129; wu:fc17d07; wu:fc37f02; wu:fk28c04; zgc:63798", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TM129; 2.3.2.27; RING-type E3 ubiquitin transferase TM129", "protein_names_refseq": "E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129", "tax_id": 7955, "disease": "", "pathway": " (dre:406756)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058876.1., [RefSeq]; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PD82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE25-1", "uniprot_id": "EF1G_DANRE", "mass": 50457.0, "length": 442, "protein_name": "Elongation factor 1-gamma", "gene_name": "eef1g", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "eef1g", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "Probably plays a role in anchoring the complex to other cellular components., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PE25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PEH1-1", "uniprot_id": "ERD22_DANRE", "mass": 24324.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 2", "gene_name": "kdelr2", "organism": "Zebrafish", "refseq_name": "ER lumen protein-retaining receptor 2", "refseq_ac": "NP_956397", "gene_names_uniprotkb": "kdelr2", "gene_names_refseq": "cb768; kdelr2a; kdelr2; wu:fa11g06; wu:fi21a12; zgc:63777", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "protein_names_refseq": "ER lumen protein-retaining receptor 2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2", "tax_id": 7955, "disease": "osteogenesis imperfecta type 21 (Disease Ontology:DOID:0112201)", "pathway": " (dre:373129); (R-DRE-6807878); (R-DRE-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058065.1, EH441091.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058065.1., [RefSeq]; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PEH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFJ1-1", "uniprot_id": "NGDN_DANRE", "mass": 36201.0, "length": 315, "protein_name": "Neuroguidin", "gene_name": "ngdn", "organism": "Zebrafish", "refseq_name": "neuroguidin", "refseq_ac": "NP_938187", "gene_names_uniprotkb": "ngdn; zgc:66416", "gene_names_refseq": "ngdn; zgc:66416", "protein_names_uniprotkb": "Neuroguidin; EIF4E-binding protein", "protein_names_refseq": "EIF4E-binding protein; neuroguidin", "tax_id": 7955, "disease": "", "pathway": " (dre:386642)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152215.1, EH507985.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH556584.1, BC057531.1, EH507985.1, EH534128.1 and BM533592.1. On or before Jun 6, 2009 this sequence version replaced NP_001098603.1, NP_938187.1., [RefSeq]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). May inhibit mRNA translation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006417 regulation of translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PFJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFJ7-1", "uniprot_id": "NSMA3_DANRE", "mass": 89990.0, "length": 791, "protein_name": "Sphingomyelin phosphodiesterase 4", "gene_name": "smpd4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "smpd4; zgc:66367", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 4; 3.1.4.12; Neutral sphingomyelinase 3; Neutral sphingomyelinase III; nSMase-3; nSMase3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:793294); (R-DRE-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.12", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0050290 sphingomyelin phosphodiesterase D activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0046475 glycerophospholipid catabolic process;GO:0071356 cellular response to tumor necrosis factor;GO:0006685 sphingomyelin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PFJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFL0-1", "uniprot_id": "MED27_DANRE", "mass": 35672.0, "length": 311, "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "med27", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 27", "refseq_ac": "NP_956954", "gene_names_uniprotkb": "med27; crsp34; crsp8; zgc:66302", "gene_names_refseq": "crsp8; med27; zgc:66302", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 27; CRSP complex subunit 8; Cofactor required for Sp1 transcriptional activation subunit 8; Mediator complex subunit 27", "protein_names_refseq": "CRSP complex subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; crsp34; mediator of RNA polymerase II transcription subunit 27; trap37", "tax_id": 7955, "disease": "", "pathway": " (dre:393633)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16582438", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057508.1, EH580031.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505380, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057508.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for the development of dopaminergic amacrine cells in the retina. May also negatively regulate the development of rod photoreceptor cells., [UniProtKB, PubMed]; Ubiquitous expression of crsp34 mRNA may suggest a universal requirement for Crsp34 in transcriptional initiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043010 camera-type eye development;GO:0046549 retinal cone cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PFL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFQ2-1", "uniprot_id": "EIF3C_DANRE", "mass": 106367.0, "length": 926, "protein_name": "Eukaryotic translation initiation factor 3 subunit C", "gene_name": "eif3c", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit C", "refseq_ac": "NP_998628", "gene_names_uniprotkb": "eif3c; EIF3C; EIF3S8; eif3s8; fi37c04; wu:fb34a08; wu:fi37c04; zgc:66128", "gene_names_refseq": "eif3c; eif3s8; fi37c04; wu:fb34a08; wu:fi37c04; zgc:66128", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation factor 3 subunit 8; eIF3c", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit C; eukaryotic translation initiation factor 3, subunit 8, 110kDa", "tax_id": 7955, "disease": "", "pathway": " (dre:334234); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "18307296;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057465.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC057465.1. On Jul 6, 2005 this sequence version replaced XP_693592.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PFQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFS5-1", "uniprot_id": "ERD23_DANRE", "mass": 24825.0, "length": 215, "protein_name": "ER lumen protein-retaining receptor 3", "gene_name": "kdelr3", "organism": "Zebrafish", "refseq_name": "ER lumen protein-retaining receptor 3", "refseq_ac": "NP_956934", "gene_names_uniprotkb": "kdelr3; zgc:64171", "gene_names_refseq": "kdelr3; zgc:64171", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3", "protein_names_refseq": "ER lumen protein-retaining receptor 3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL receptor 3", "tax_id": 7955, "disease": "", "pathway": " (dre:393613); (R-DRE-6807878); (R-DRE-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057436.1, EH451963.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jun 25, 2025 this sequence version replaced NP_956934.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network;GO:0030663 COPI-coated vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PFS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFT9-1", "uniprot_id": "AB1IP_DANRE", "mass": 71002.0, "length": 646, "protein_name": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein", "gene_name": "apbb1ip", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "apbb1ip", "gene_names_refseq": "", "protein_names_uniprotkb": "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393607); (R-DRE-354192); (R-DRE-354194); (R-DRE-5674135)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PFT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PG31-1", "uniprot_id": "RNPS1_DANRE", "mass": 31739.0, "length": 283, "protein_name": "RNA-binding protein with serine-rich domain 1", "gene_name": "rnps1", "organism": "Zebrafish", "refseq_name": "RNA-binding protein with serine-rich domain 1", "refseq_ac": "NP_956055", "gene_names_uniprotkb": "rnps1; wu:fa19a11; zgc:65775", "gene_names_refseq": "rnps1; wu:fa19a11; zgc:65775", "protein_names_uniprotkb": "RNA-binding protein with serine-rich domain 1", "protein_names_refseq": "RNA-binding protein with serine-rich domain 1", "tax_id": 7955, "disease": "", "pathway": " (dre:327020); (R-DRE-159236); (R-DRE-72163); (R-DRE-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01020244.1, BC057251.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Jun 25, 2025 this sequence version replaced NP_956055.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZV7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0061574 ASAP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PG31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGX3-1", "uniprot_id": "LRFN1_DANRE", "mass": 64563.0, "length": 584, "protein_name": "Leucine-rich repeat and fibronectin type III domain-containing protein 1", "gene_name": "lrfn1", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor", "refseq_ac": "NP_956909", "gene_names_uniprotkb": "lrfn1; mb21d2b; zgc:63670", "gene_names_refseq": "lrfn1; mb21d2b; zgc:63670", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type III domain-containing protein 1", "protein_names_refseq": "Mab-21 domain containing 2b; leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor; leucine-rich repeat and fibronectin type III domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:393587); (R-DRE-8849932)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18296487", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.5584297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jul 3, 2025 this sequence version replaced XP_073778933.1, NP_956909.2., [RefSeq]; Involved in the regulation of excitatory synapses., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A8BBG4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGY5-1", "uniprot_id": "DJC21_DANRE", "mass": 62766.0, "length": 545, "protein_name": "DnaJ homolog subfamily C member 21", "gene_name": "dnajc21", "organism": "Zebrafish", "refseq_name": "dnaJ homolog subfamily C member 21", "refseq_ac": "NP_956338", "gene_names_uniprotkb": "dnajc21; dnaja5; zgc:63563", "gene_names_refseq": "dnajc21; fa66c02; wu:fa66c02; zgc:63563", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 21; DnaJ homolog subfamily A member 5", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 21; dnaJ homolog subfamily A member 5; dnaJ homolog subfamily C member 21; dnaja5", "tax_id": 7955, "disease": "", "pathway": " (dre:336984)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC056785.1 [ECO:0000331] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056785.1., [RefSeq]; May act as a co-chaperone for HSP70., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PGY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGZ0-1", "uniprot_id": "CEP63_DANRE", "mass": 83092.0, "length": 716, "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "cep63", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 63 kDa", "refseq_ac": "NP_956896", "gene_names_uniprotkb": "cep63; zgc:63548", "gene_names_refseq": "cep63; zgc:63548", "protein_names_uniprotkb": "Centrosomal protein of 63 kDa; Cep63", "protein_names_refseq": "centrosomal protein of 63 kDa", "tax_id": 7955, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Seckel syndrome 6 (Disease Ontology:DOID:0070006)", "pathway": " (dre:393574); (R-DRE-380320)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06645147, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056780.1., [RefSeq]; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division;GO:0042770 signal transduction in response to DNA damage;GO:0000077 DNA damage checkpoint signaling;GO:0051225 spindle assembly;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PGZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGZ7-1", "uniprot_id": "Q6PGZ7_DANRE", "mass": 54877.0, "length": 492, "protein_name": "Interferon regulatory factor 6", "gene_name": "irf6", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 6", "refseq_ac": "NP_956892", "gene_names_uniprotkb": "irf6; zgc:63500", "gene_names_refseq": "irf6; zgc:63500", "protein_names_uniprotkb": "Interferon regulatory factor 6", "protein_names_refseq": "interferon regulatory factor 6", "tax_id": 7955, "disease": "popliteal pterygium syndrome (Disease Ontology:DOID:0060055); Van der Woude syndrome (Disease Ontology:DOID:0060239); orofacial cleft 6 (Disease Ontology:DOID:0080593); syndactyly (Disease Ontology:DOID:11193); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:393570)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15939375;18039395;19013452;19896215;20444275;32471880;32582293;33234718;35464458;38370976", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY725802.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY725802.2. On Jul 6, 2005 this sequence version replaced XP_702300.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of zebrafish expression of IRF6, [RefSeq, PubMed]; These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IR88;Q52YL6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060429 epithelium development;GO:1905748 hard palate morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PGZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PH11-1", "uniprot_id": "PYM1_DANRE", "mass": 22066.0, "length": 194, "protein_name": "Partner of Y14 and mago", "gene_name": "pym1", "organism": "Zebrafish", "refseq_name": "partner of Y14 and mago isoform 1", "refseq_ac": "NP_956888", "gene_names_uniprotkb": "pym1; pym; wibg; zgc:65891", "gene_names_refseq": "pym1; wibg; zgc:65891; zgc:77281", "protein_names_uniprotkb": "Partner of Y14 and mago; PYM homolog 1 exon junction complex-associated factor; Protein wibg homolog", "protein_names_refseq": "partner of Y14 and mago isoform 1; partner of Y14 and mago; protein wibg homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:393566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1238335.1, SRR26395017.1204739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 18, 2004 this sequence version replaced NP_956888.1., [RefSeq]; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NVC8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:1903259 exon-exon junction complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PH11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PH19-1", "uniprot_id": "GATM_DANRE", "mass": 48075.0, "length": 422, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "gatm", "organism": "Zebrafish", "refseq_name": "glycine amidinotransferase, mitochondrial", "refseq_ac": "NP_955825", "gene_names_uniprotkb": "gatm", "gene_names_refseq": "cb409; gatm; wu:fa08a06; zgc:65855", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "agat; glycine amidinotransferase, mitochondrial", "tax_id": 7955, "disease": "AGAT deficiency (Disease Ontology:DOID:0050712); Fanconi renotubular syndrome 1 (Disease Ontology:DOID:0080757); pre-eclampsia (Disease Ontology:DOID:10591); acute kidney failure (Disease Ontology:DOID:3021); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:266799); (R-DRE-71288)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17486546;20409172", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056747.1, BC067594.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056747.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity)., [UniProtKB]; The spatiotemporal expression pattern of gatm during zebrafish embryogenesis was revealed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.4.1", "go_molecular_function": "GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006601 creatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PH19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PH57-1", "uniprot_id": "GBB1_DANRE", "mass": 37286.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "gene_name": "gnb1", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "refseq_ac": "NP_997774", "gene_names_uniprotkb": "gnb1", "gene_names_refseq": "gnb1a; gnb1; wu:fb50b09; wu:fj94h04", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1", "protein_names_refseq": "guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; transducin beta chain 1", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 42 (Disease Ontology:DOID:0070072); congestive heart failure (Disease Ontology:DOID:6000); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:322104); (R-DRE-202040); (R-DRE-2485179); (R-DRE-381676); (R-DRE-381753); (R-DRE-381771); (R-DRE-392170); (R-DRE-400042); (R-DRE-416476); (R-DRE-418594); (R-DRE-418597); (R-DRE-420092); (R-DRE-428930); (R-DRE-432040); (R-DRE-456926); (R-DRE-6814122); (R-DRE-9717207); (R-DRE-9856530)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "22096073;28554852", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056708.1, BC071277.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056708.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Gbetagamma signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB]; The data indicate that Gbeta1 signaling controls proper neutrophil migration by activating Phosphatidylinositol 3-Kinase and modulating actin dynamics. Moreover, they illustrate a role for a specific Gbeta isoform in chemotaxis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:1902624 positive regulation of neutrophil migration;GO:0048920 posterior lateral line neuromast primordium migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PH57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHD9-1", "uniprot_id": "SBP1_DANRE", "mass": 50983.0, "length": 457, "protein_name": "Methanethiol oxidase", "gene_name": "selenbp1", "organism": "Zebrafish", "refseq_name": "methanethiol oxidase", "refseq_ac": "NP_956864", "gene_names_uniprotkb": "selenbp1", "gene_names_refseq": "MTO; selenbp1; zgc:65844", "protein_names_uniprotkb": "Methanethiol oxidase; 1.8.3.4; MTO; Selenium-binding protein 1", "protein_names_refseq": "methanethiol oxidase", "tax_id": 7955, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (dre:393542)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01034503.1, GDQH01001318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Jul 29, 2025 this sequence version replaced XP_005158264.1, NP_956864.1., [RefSeq]; Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (By similarity). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.3.4", "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PHD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHE8-1", "uniprot_id": "CC124_DANRE", "mass": 25187.0, "length": 216, "protein_name": "Coiled-coil domain-containing protein 124", "gene_name": "ccdc124", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 124", "refseq_ac": "NP_956859", "gene_names_uniprotkb": "ccdc124; si:ch211-200a16.3; zgc:65939; zgc:77492", "gene_names_refseq": "ccdc124; wu:fj17b05; zgc:65939; zgc:77492", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 124", "protein_names_refseq": "coiled-coil domain-containing protein 124", "tax_id": 7955, "disease": "", "pathway": " (dre:393537)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398375.1, CK025253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY398375.1., [RefSeq]; Ribosome-binding protein involved in ribosome hibernation: associates with translationally inactive ribosomes and stabilizes the nonrotated conformation of the 80S ribosome, thereby promoting ribosome preservation and storage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0030496 midbody", "go_biological_process": "GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PHE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHG2-1", "uniprot_id": "HEMO_DANRE", "mass": 51027.0, "length": 447, "protein_name": "Hemopexin", "gene_name": "hpx", "organism": "Zebrafish", "refseq_name": "hemopexin precursor", "refseq_ac": "NP_001315463", "gene_names_uniprotkb": "hpx", "gene_names_refseq": "hpx a; hpxa; hpx; wu:fi17f11; wu:fi19a10", "protein_names_uniprotkb": "Hemopexin", "protein_names_refseq": "hemopexin precursor; hemopexin", "tax_id": 7955, "disease": "", "pathway": " (dre:327588)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056563.1, GFIL01012845.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1 and BC056563.1. On Jun 17, 2016 this sequence version replaced XP_009302995.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A9JSW7", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015232 heme transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PHG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHG4-1", "uniprot_id": "LIAS_DANRE", "mass": 44394.0, "length": 399, "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "lias", "organism": "Zebrafish", "refseq_name": "lipoyl synthase, mitochondrial", "refseq_ac": "NP_001103871", "gene_names_uniprotkb": "lias; zgc:66080", "gene_names_refseq": "LS; lias; zgc:66080", "protein_names_uniprotkb": "Lipoyl synthase, mitochondrial; 2.8.1.8; LS; Lip-syn; Lipoate synthase; Lipoic acid synthase", "protein_names_refseq": "lipoyl synthase, mitochondrial", "tax_id": 7955, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (dre:393528); (R-DRE-9857492)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC154781.1, BC056561.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC154781.1. On or before Apr 18, 2008 this sequence version replaced NP_956850.1, XP_683338.1., [RefSeq]; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WGN4", "ec_number_list": "2.8.1.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016992 lipoate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation;GO:0009107 lipoate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PHG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHG8-1", "uniprot_id": "RPA43_DANRE", "mass": 43286.0, "length": 391, "protein_name": "DNA-directed RNA polymerase I subunit RPA43", "gene_name": "polr1f", "organism": "Zebrafish", "refseq_name": "DNA-directed RNA polymerase I subunit RPA43", "refseq_ac": "NP_001007154", "gene_names_uniprotkb": "polr1f; twistnb", "gene_names_refseq": "polr1f; twistnb", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA43; DNA-directed RNA polymerase I subunit F; Twist neighbor protein", "protein_names_refseq": "DNA-directed RNA polymerase I subunit F; DNA-directed RNA polymerase I subunit RPA43; twist neighbor protein", "tax_id": 7955, "disease": "", "pathway": " (dre:402856); (R-DRE-5250924); (R-DRE-73762); (R-DRE-73772); (R-DRE-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15256591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648783.1, BC064328.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY648783.1., [RefSeq]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DRH6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PHG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHK6-1", "uniprot_id": "PURB_DANRE", "mass": 32606.0, "length": 297, "protein_name": "Transcriptional regulator protein Pur-beta", "gene_name": "purb", "organism": "Zebrafish", "refseq_name": "transcriptional regulator protein Pur-beta", "refseq_ac": "NP_956841", "gene_names_uniprotkb": "purb", "gene_names_refseq": "purbb; purb; zgc:65916", "protein_names_uniprotkb": "Transcriptional regulator protein Pur-beta; Purine-rich element-binding protein B", "protein_names_refseq": "purine-rich element-binding protein B; transcriptional activator protein Pur-beta; transcriptional regulator protein Pur-beta", "tax_id": 7955, "disease": "", "pathway": " (dre:393519)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056517.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056517.1., [RefSeq]; Transcriptional regulator which can act as an activator or a repressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NW99", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0032422 purine-rich negative regulatory element binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PHK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHY8-1", "uniprot_id": "SELTB_DANRE", "mass": 22386.0, "length": 193, "protein_name": "Thioredoxin reductase-like selenoprotein T1b", "gene_name": "selenot1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "selenot1b; selt1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T1b; 1.8.1.9", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:352921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12915322", "class_list": "", "function": "Selenoprotein with thioredoxin reductase-like oxidoreductase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q802G5", "ec_number_list": "1.8.1.9", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PHY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PI52-1", "uniprot_id": "CALM_DANRE", "mass": 16838.0, "length": 149, "protein_name": "Calmodulin", "gene_name": "calm1a; calm1b; calm2a; calm2b; calm3a; calm3b", "organism": "Zebrafish", "refseq_name": "calmodulin 3a (phosphorylase kinase, delta)", "refseq_ac": "NP_892012", "gene_names_uniprotkb": "calm1a; calm1b; calm2a; calm2b; calm3a; calm3b; calm2d; calm2g; zgc:63926; zgc:64036; zgc:76987; zgc:86728", "gene_names_refseq": "CaMgamma; calm2g; calm3a; wu:fi05b08; zgc:86728", "protein_names_uniprotkb": "Calmodulin; CaM", "protein_names_refseq": "CaM3 Gamma; calmodulin 2, gamma; calmodulin 3a (phosphorylase kinase, delta)", "tax_id": 7955, "disease": "", "pathway": " (dre:192322); (dre:321808); (dre:327379); (dre:336121); (dre:368217); (dre:406660)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045298.1, EH115322.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045298.1. On Jul 6, 2005 this sequence version replaced XP_690003.1., [RefSeq]; Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V949", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043209 myelin sheath", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PI52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PUF3-1", "uniprot_id": "DHI1L_DANRE", "mass": 31918.0, "length": 287, "protein_name": "Hydroxysteroid 11-beta-dehydrogenase 1-like protein", "gene_name": "hsd11b1l", "organism": "Zebrafish", "refseq_name": "hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor", "refseq_ac": "NP_956617", "gene_names_uniprotkb": "hsd11b1l; hsd11b3; hsd3; si:dkey-78l4.15; zgc:56373", "gene_names_refseq": "11-DH3; hsd11b1la; hsd11b1l; hsd11b3a; hsd11b3; hsd3; sdr10b; si:dkey-78l4.15; zgc:56373", "protein_names_uniprotkb": "Hydroxysteroid 11-beta-dehydrogenase 1-like protein; 1.1.1.-; 11-DH3; 11-beta-HSD3; 11-beta-hydroxysteroid dehydrogenase type 3", "protein_names_refseq": "11-beta-HSD3; 11-beta-hydroxysteroid dehydrogenase type 3; SDR family oxidoreductase; hydroxysteroid (11-beta) dehydrogenase 3a; hydroxysteroid (11-beta) dehydrogenase 3; hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor; hydroxysteroid 11-beta-dehydrogenase 1-like protein; short-chain dehydrogenase/reductase 10", "tax_id": 7955, "disease": "cortisone reductase deficiency (Disease Ontology:DOID:0090139); cortisone reductase deficiency 2 (Disease Ontology:DOID:0090140); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); status epilepticus (Disease Ontology:DOID:1824); coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:393293); (R-DRE-194002); (R-DRE-9757110)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071452.1, AY578180.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC071452.1. On or before Oct 28, 2023 this sequence version replaced NP_001099077.1, NP_956617.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Unidirectional NADP(+)-dependent cortisol dehydrogenase (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-", "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0016491 oxidoreductase activity;GO:0102196 cortisol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PUF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Q415-1", "uniprot_id": "RL36_DANRE", "mass": 12180.0, "length": 105, "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "rpl36", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein eL36", "refseq_ac": "NP_998117", "gene_names_uniprotkb": "rpl36", "gene_names_refseq": "rpl36; zgc:86707", "protein_names_uniprotkb": "Large ribosomal subunit protein eL36; 60S ribosomal protein L36", "protein_names_refseq": "60S ribosomal protein L36; large ribosomal subunit protein eL36", "tax_id": 7955, "disease": "", "pathway": " (dre:405888); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "15138505;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC071384.1, CN320310.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC071384.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0007420 brain development;GO:0002181 cytoplasmic translation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6Q415-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R3Q6-1", "uniprot_id": "BSH_DANRE", "mass": 26469.0, "length": 227, "protein_name": "Brain-specific homeobox protein homolog", "gene_name": "bsx", "organism": "Zebrafish", "refseq_name": "brain-specific homeobox protein homolog", "refseq_ac": "NP_999892", "gene_names_uniprotkb": "bsx", "gene_names_refseq": "bsx", "protein_names_uniprotkb": "Brain-specific homeobox protein homolog", "protein_names_refseq": "brain-specific homeobox protein homolog; brain-specific homeodomain protein", "tax_id": 7955, "disease": "", "pathway": " (dre:573364)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29945867;31602413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY515251.1, EH579801.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476730, SAMEA4476744 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY515251.1. On Jan 26, 2008 this sequence version replaced XP_692813.1., [RefSeq]; Bsx has a pivotal role in the differentiation of multiple cell types in the zebrafish pineal complex. Publication Status: Online-Only, [RefSeq, PubMed]; Bsx knock-down impaired the pineal development with reduced expression of exorh, the pineal-specific gene responsible for the photoreception, whereas it induced ectopic expression of rho, a retina-specific gene, in the pineal gland. Bsx remarkably transactivated the exorh promoter in combination with Otx5, but not with Crx, through its binding to distinct subtypes of PIRE. Publication Status: Online-Only, [RefSeq, PubMed]; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007420 brain development;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6R3Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RVD7-1", "uniprot_id": "SX21B_DANRE", "mass": 26801.0, "length": 245, "protein_name": "Transcription factor Sox-21-B", "gene_name": "sox21b", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-21-B", "refseq_ac": "NP_001009888", "gene_names_uniprotkb": "sox21b; si:ch211-247e2.1; zgc:110678", "gene_names_refseq": "sox21b; zgc:110678", "protein_names_uniprotkb": "Transcription factor Sox-21-B; SRY-box containing gene 21b", "protein_names_refseq": "SRY (sex determining region Y)-box 21b; transcription factor Sox-21-B", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dre:406246)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15037315;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095366.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095366.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a negative regulator of transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6RVD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEL3-1", "uniprot_id": "C42S1_DANRE", "mass": 8350.0, "length": 75, "protein_name": "CDC42 small effector protein 1", "gene_name": "cdc42se1", "organism": "Zebrafish", "refseq_name": "CDC42 small effector protein 1", "refseq_ac": "NP_956354", "gene_names_uniprotkb": "cdc42se1; si:dkey-77n11.2; spec1; wu:fa55c04; wu:fc05d06; zgc:55642", "gene_names_refseq": "cdc42se1; spec1; wu:fa55c04; wu:fc05d06; zgc:55642", "protein_names_uniprotkb": "CDC42 small effector protein 1", "protein_names_refseq": "CDC42 small effector protein 1; small protein effector 1 of Cdc42", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY423037.1, BC044443.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH593343.1, EB933762.1, EB978640.1, EH582597.1, JBMGRA010000016.1, EB890912.1 and EB983056.1. On May 23, 2007 this sequence version replaced XP_001331503.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TEL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEN6-1", "uniprot_id": "WDR91_DANRE", "mass": 80767.0, "length": 724, "protein_name": "WD repeat-containing protein 91", "gene_name": "wdr91", "organism": "Zebrafish", "refseq_name": "WD repeat-containing protein 91", "refseq_ac": "NP_991168", "gene_names_uniprotkb": "wdr91; hspc049l", "gene_names_refseq": "HSPC049; hspc049l; wdr91", "protein_names_uniprotkb": "WD repeat-containing protein 91", "protein_names_refseq": "WD repeat-containing protein 91", "tax_id": 7955, "disease": "", "pathway": " (dre:402898); (R-DRE-9013148)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY423013.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505378 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY423013.1., [RefSeq]; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0045022 early endosome to late endosome transport;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TEN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEP1-1", "uniprot_id": "F91A1_DANRE", "mass": 93048.0, "length": 831, "protein_name": "Protein FAM91A1", "gene_name": "fam91a1", "organism": "Zebrafish", "refseq_name": "protein FAM91A1", "refseq_ac": "NP_956735", "gene_names_uniprotkb": "fam91a1; si:dkey-5e12.2; zgc:63609", "gene_names_refseq": "fam91a1; zgc:63609", "protein_names_uniprotkb": "Protein FAM91A1", "protein_names_refseq": "protein FAM91A1", "tax_id": 7955, "disease": "", "pathway": " (dre:393413); (R-DRE-9013407)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054922.1., [RefSeq]; As component of the WDR11 complex may act together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SYC3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099041 vesicle tethering to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TEP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TGS6-1", "uniprot_id": "SYYC_DANRE", "mass": 59534.0, "length": 529, "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "yars1", "organism": "Zebrafish", "refseq_name": "tyrosine--tRNA ligase, cytoplasmic", "refseq_ac": "NP_958473", "gene_names_uniprotkb": "yars1; cb204; wu:fk52b08; yars", "gene_names_refseq": "cb204; wu:fk52b08; yars1; yars", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, cytoplasmic; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrRS; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease dominant intermediate C (Disease Ontology:DOID:0110199); multisystem proteinopathy (Disease Ontology:DOID:070355); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); cancer (Disease Ontology:DOID:162); neuropathy (Disease Ontology:DOID:870)", "pathway": " (dre:368235)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398430.1, BC076558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY398430.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DFZ7", "ec_number_list": "6.1.1.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004831 tyrosine-tRNA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0006437 tyrosyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TGS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TGY8-1", "uniprot_id": "EMC2_DANRE", "mass": 34456.0, "length": 297, "protein_name": "ER membrane protein complex subunit 2", "gene_name": "emc2", "organism": "Zebrafish", "refseq_name": "ER membrane protein complex subunit 2", "refseq_ac": "NP_998709", "gene_names_uniprotkb": "emc2; ttc35; zgc:86891", "gene_names_refseq": "emc2; ttc35; zgc:73154; zgc:86891", "protein_names_uniprotkb": "ER membrane protein complex subunit 2; TPR repeat protein 35; Tetratricopeptide repeat protein 35", "protein_names_refseq": "ER membrane protein complex subunit 2; TPR repeat protein 35; tetratricopeptide repeat domain 35; tetratricopeptide repeat protein 35", "tax_id": 7955, "disease": "", "pathway": " (dre:407073)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY398368.1, BC071517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY398368.1., [RefSeq]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042406 extrinsic component of endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TGY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TGZ5-1", "uniprot_id": "HPPD_DANRE", "mass": 45211.0, "length": 397, "protein_name": "4-hydroxyphenylpyruvate dioxygenase a", "gene_name": "hpda", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hpda; fb58f02; hpd; wu:fb58f02; zgc:56326", "gene_names_refseq": "", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase a; 1.13.11.27; 2.1.1.348; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; N(6)-adenosine-methyltransferase HPD", "protein_names_refseq": "", "tax_id": 7955, "disease": "tyrosinemia type III (Disease Ontology:DOID:0050727); hawkinsinuria (Disease Ontology:DOID:0111362)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.348;2.1.1.-;2.1.1.346;1.13.11.27", "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004462 lactoylglutathione lyase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TGZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TH15-1", "uniprot_id": "EIF3D_DANRE", "mass": 64090.0, "length": 552, "protein_name": "Eukaryotic translation initiation factor 3 subunit D", "gene_name": "eif3d", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit D", "refseq_ac": "NP_956310", "gene_names_uniprotkb": "eif3d; eif3s7; si:dkey-165I8.6", "gene_names_refseq": "eif3d; eif3s7; wu:fb12a03; zgc:64097", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit D; Eukaryotic translation initiation factor 3 subunit 7; eIF3d", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3, subunit 7 zeta", "tax_id": 7955, "disease": "", "pathway": " (dre:336498); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "15256591;15520368;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053250.1, AY648769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053250.1., [RefSeq]; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BHH8;Q7T353", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6TH15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TH47-1", "uniprot_id": "STBPA_DANRE", "mass": 47510.0, "length": 418, "protein_name": "STAM-binding protein-like A", "gene_name": "stambpa", "organism": "Zebrafish", "refseq_name": "STAM-binding protein-like A", "refseq_ac": "NP_956792", "gene_names_uniprotkb": "stambpa; amsh; stambp", "gene_names_refseq": "stambpa; stambp; zgc:66147", "protein_names_uniprotkb": "STAM-binding protein-like A; 3.4.19.-", "protein_names_refseq": "STAM-binding protein-like A", "tax_id": 7955, "disease": "", "pathway": " (dre:797422)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055512.1, AY398309.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055512.1. On Jan 25, 2008 this sequence version replaced XP_001334844.1., [RefSeq]; Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZV76;Q7SXP3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005768 endosome;GO:0032154 cleavage furrow", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TH47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TLE4-1", "uniprot_id": "EMC5_DANRE", "mass": 14779.0, "length": 130, "protein_name": "ER membrane protein complex subunit 5", "gene_name": "mmgt1", "organism": "Zebrafish", "refseq_name": "ER membrane protein complex subunit 5", "refseq_ac": "NP_991162", "gene_names_uniprotkb": "mmgt1; emc5; zgc:92918", "gene_names_refseq": "mmgt1; tmem32; zgc:92918", "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Membrane magnesium transporter 1", "protein_names_refseq": "ER membrane protein complex subunit 5; transmembrane protein 32", "tax_id": 7955, "disease": "", "pathway": " (dre:402891)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394962.1, EH455504.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394962.1., [RefSeq]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TLE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TLE6-1", "uniprot_id": "CRCM1_DANRE", "mass": 24633.0, "length": 222, "protein_name": "Calcium release-activated calcium channel protein 1", "gene_name": "orai1", "organism": "Zebrafish", "refseq_name": "calcium release-activated calcium channel protein 1", "refseq_ac": "NP_991163", "gene_names_uniprotkb": "orai1; tmem142a; zgc:109721", "gene_names_refseq": "im:7146264; orai1b; orai1; tmem142a; zgc:109721", "protein_names_uniprotkb": "Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A", "protein_names_refseq": "ORAI calcium release-activated calcium modulator 1; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A", "tax_id": 7955, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 2 (Disease Ontology:DOID:0080686); immunodeficiency 9 (Disease Ontology:DOID:0111976); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:402892)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;22302996;27702423", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394960.1, BC094965.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394960.1., [RefSeq]; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores., [UniProtKB, UniProtKB]; Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos., [RefSeq, PubMed]; The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q504L0", "ec_number_list": "", "go_molecular_function": "GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002250 adaptive immune response;GO:0045214 sarcomere organization;GO:0051928 positive regulation of calcium ion transport;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6TLE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TLF6-1", "uniprot_id": "RGN_DANRE", "mass": 32809.0, "length": 295, "protein_name": "Regucalcin", "gene_name": "rgn", "organism": "Zebrafish", "refseq_name": "regucalcin isoform 1", "refseq_ac": "NP_991309", "gene_names_uniprotkb": "rgn; GNL; zgc:92078", "gene_names_refseq": "GNL; rgn; zgc:92078", "protein_names_uniprotkb": "Regucalcin; 3.1.1.17; GNL; Gluconolactonase; RC", "protein_names_refseq": "RC; gluconolactonase; regucalcin isoform 1", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15520368;21951853;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588716.39299229.1, EH579915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On or before Jun 23, 2025 this sequence version replaced XP_073808878.1, NP_991309.1., [RefSeq]; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)., [UniProtKB]; SMP30/RGN is important for liver proliferation and tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.17", "go_molecular_function": "GO:0004341 gluconolactonase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0032781 positive regulation of ATP-dependent activity;GO:0019853 L-ascorbic acid biosynthetic process;GO:0050848 regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6TLF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TNP8-1", "uniprot_id": "VP26A_DANRE", "mass": 38178.0, "length": 327, "protein_name": "Vacuolar protein sorting-associated protein 26A", "gene_name": "vps26a", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 26A", "refseq_ac": "NP_957201", "gene_names_uniprotkb": "vps26a; vps26; wu:fc67e06; zgc:56673", "gene_names_refseq": "vps26a; vps26; wu:fc67e06; zgc:56673", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 26A; Vesicle protein sorting 26A", "protein_names_refseq": "vacuolar protein sorting 26 homolog A; vacuolar protein sorting-associated protein 26A; vesicle protein sorting 26A", "tax_id": 7955, "disease": "brain cancer (Disease Ontology:DOID:1319); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393881); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049342.1, BC155773.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049342.1. On or before Jul 6, 2005 this sequence version replaced XP_686469.1, XP_708442.1., [RefSeq]; Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZUB5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TNP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TNS7-1", "uniprot_id": "RABL3_DANRE", "mass": 26113.0, "length": 233, "protein_name": "Rab-like protein 3", "gene_name": "rabl3", "organism": "Zebrafish", "refseq_name": "rab-like protein 3", "refseq_ac": "NP_991296", "gene_names_uniprotkb": "rabl3; zgc:100876", "gene_names_refseq": "fb40b02; rabl3; wu:fb40b02; zgc:100876", "protein_names_uniprotkb": "Rab-like protein 3; 3.6.5.2", "protein_names_refseq": "rab-like protein 3", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:403048)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;31406347", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY391440.1, CK027961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY391440.1., [RefSeq]; Small GTPase required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity). Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006886 intracellular protein transport;GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus;GO:0046578 regulation of Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TNS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VNZ9-1", "uniprot_id": "MYF6_DANRE", "mass": 27032.0, "length": 239, "protein_name": "Myogenic factor 6", "gene_name": "myf6", "organism": "Zebrafish", "refseq_name": "myogenic factor 6", "refseq_ac": "NP_001003982", "gene_names_uniprotkb": "myf6; herculin; mrf4", "gene_names_refseq": "herculin; mrf4; myf6", "protein_names_uniprotkb": "Myogenic factor 6; Muscle-specific regulatory factor 4; Myf-6", "protein_names_refseq": "muscle-specific regulatory factor 4; myf-6; myogenic factor 6", "tax_id": 7955, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congenital structural myopathy (Disease Ontology:DOID:422)", "pathway": " (dre:404208)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17638597;18297736;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163755.1, AY335193.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that the transcript Mrf4_tv2 is involved in alignment of muscle fibers, and Mrf4_tv1 might have cooperative function with Mrf4_tv2 in muscle fiber alignment, without affecting the muscle-nerve connection., [RefSeq, PubMed]; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity)., [UniProtKB]; Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation;GO:0007519 skeletal muscle tissue development;GO:0048743 positive regulation of skeletal muscle fiber development;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6VNZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6W990-1", "uniprot_id": "HXADA_DANRE", "mass": 33745.0, "length": 310, "protein_name": "Homeobox protein Hox-A13a", "gene_name": "hoxa13a", "organism": "Zebrafish", "refseq_name": "homeobox protein Hox-A13a", "refseq_ac": "NP_001078963", "gene_names_uniprotkb": "hoxa13a", "gene_names_refseq": "hoxa13a; hoxa13", "protein_names_uniprotkb": "Homeobox protein Hox-A13a", "protein_names_refseq": "homeo box A13a; homeobox gene A-13; homeobox protein Hox-A13a", "tax_id": 7955, "disease": "hand-foot-genital syndrome (Disease Ontology:DOID:0060739); Guttmacher syndrome (Disease Ontology:DOID:0111544); hypospadias (Disease Ontology:DOID:10892)", "pathway": " (dre:570239)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14707165;23594743;9831563", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133882.1, EH504711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC133882.1. On May 23, 2007 this sequence version replaced XP_698788.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1L974;Q9YGT9", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0033333 fin development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6W990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZM19-1", "uniprot_id": "IF6_DANRE", "mass": 26645.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "eif6", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 6", "refseq_ac": "NP_957238", "gene_names_uniprotkb": "eif6; EIF6; Itgb4bp; eIF-6; itgb4bp4; si:ch211-239j9.6; wu:fc28a04; wu:ft88f05; zgc:56562", "gene_names_refseq": "Itgb4bp; eIF-6; eif6; itgb4bp4; wu:fc28a04; wu:ft88f05; zgc:56562", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; eIF-6", "protein_names_refseq": "eukaryotic translation initiation factor 6; integrin beta 4 binding protein", "tax_id": 7955, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15520368;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049488.1, AY398366.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049488.1., [RefSeq]; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQN0;Q7ZWC1", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000460 maturation of 5.8S rRNA;GO:0042256 cytosolic ribosome assembly;GO:0000470 maturation of LSU-rRNA;GO:1902626 assembly of large subunit precursor of preribosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6ZM19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZM28-1", "uniprot_id": "HRG1B_DANRE", "mass": 16518.0, "length": 144, "protein_name": "Heme transporter hrg1-B", "gene_name": "slc48a1a", "organism": "Zebrafish", "refseq_name": "heme transporter hrg1-B", "refseq_ac": "NP_001002424", "gene_names_uniprotkb": "slc48a1a; hrg1b; si:ch211-226m16.1; zgc:92662", "gene_names_refseq": "slc48a1a; zgc:92662", "protein_names_uniprotkb": "Heme transporter hrg1-B; HRG-1B; Heme-responsive gene 1 protein homolog B; Solute carrier family 48 member 1-A", "protein_names_refseq": "HRG-1B; heme transporter hrg1-B; heme-responsive gene 1 protein homolog B; solute carrier family 48 (heme transporter), member 1a; solute carrier family 48 member 1-A", "tax_id": 7955, "disease": "", "pathway": " (dre:436697)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30248094", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076146.1, CK354291.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476761, SAMEA4476774 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076146.1., [RefSeq]; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP)., [UniProtKB, UniProtKB]; Study results show that zebrafish Hrg1a and its paralog Hrg1b are functional heme transporters, and genetic ablation of both transporters in double knockout animals shows lower iron accumulation concomitant with higher amounts of heme sequestered in kidney macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DH36", "ec_number_list": "", "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0030670 phagocytic vesicle membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0015886 heme transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6ZM28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZM34-1", "uniprot_id": "Q6ZM34_DANRE", "mass": 95281.0, "length": 831, "protein_name": "Vacuolar protein sorting-associated protein 35", "gene_name": "vps35", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 35", "refseq_ac": "NP_001020688", "gene_names_uniprotkb": "vps35; bZ34G2.3; si:rp71-34g2.3; wu:fa66e03; wu:fb95c08; zgc:136268", "gene_names_refseq": "bZ34G2.3; si:rp71-34g2.3; vps35; wu:fa66e03; wu:fb95c08; zgc:136268", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 35", "protein_names_refseq": "vacuolar protein sorting 35 homolog; vacuolar protein sorting-associated protein 35", "tax_id": 7955, "disease": "Parkinson's disease 17 (Disease Ontology:DOID:0060897); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:561697); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "26161877;26469318;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139644.1, BC117573.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC139644.1 and BC117573.1. On Mar 25, 2009 this sequence version replaced NP_001020688.1., [RefSeq]; Plays a role in vesicular protein sorting., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N767", "ec_number_list": "", "go_molecular_function": "GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005770 late endosome;GO:0030904 retromer complex", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6ZM34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZM51-1", "uniprot_id": "FICD_DANRE", "mass": 50204.0, "length": 449, "protein_name": "Protein adenylyltransferase FICD", "gene_name": "ficd", "organism": "Zebrafish", "refseq_name": "protein adenylyltransferase FICD", "refseq_ac": "NP_001017794", "gene_names_uniprotkb": "ficd; fk44h08; hype; si:ch211-191d15.5; wu:fk44h08; zgc:110336", "gene_names_refseq": "ficd; fk44h08; hype; si:ch211-191d15.5; wu:fk44h08; zgc:110336", "protein_names_uniprotkb": "Protein adenylyltransferase FICD; 2.7.7.108; AMPylator FICD; FIC domain-containing protein", "protein_names_refseq": "AMPylator FICD; FIC domain containing; FIC domain-containing protein; Huntingtin interacting protein E; adenosine monophosphate-protein transferase FICD; protein adenylyltransferase FICD", "tax_id": 7955, "disease": "hereditary spastic paraplegia 92 (Disease Ontology:DOID:0070644); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092885.1, GO943033.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092885.1., [RefSeq]; Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.108", "go_molecular_function": "GO:0044603 protein adenylylhydrolase activity;GO:0005524 ATP binding;GO:0030544 Hsp70 protein binding;GO:0070733 AMPylase activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:0018117 protein adenylylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6ZM51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q701R2-1", "uniprot_id": "SIAT2_DANRE", "mass": 58533.0, "length": 514, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 2", "gene_name": "st6gal2a; st6gal2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "st6gal2a; st6gal2; ST6Gal II; St6GalII; st6gal2", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 2; 2.4.3.1; Alpha 2,6-ST 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; ST6Gal II; ST6GalII; Sialyltransferase 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:403116); (R-DRE-4085001)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15843597;20855889;22352757;26469318;27189481;30405127", "class_list": "", "function": "Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.1", "go_molecular_function": "GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q701R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71N41-1", "uniprot_id": "GAMT_DANRE", "mass": 26743.0, "length": 234, "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "gamt", "organism": "Zebrafish", "refseq_name": "guanidinoacetate N-methyltransferase", "refseq_ac": "NP_001099065", "gene_names_uniprotkb": "gamt; zgc:123136", "gene_names_refseq": "gamt; zgc:123136", "protein_names_uniprotkb": "Guanidinoacetate N-methyltransferase; 2.1.1.2", "protein_names_refseq": "guanidinoacetate N-methyltransferase", "tax_id": 7955, "disease": "guanidinoacetate methyltransferase deficiency (Disease Ontology:DOID:0050799); pre-eclampsia (Disease Ontology:DOID:10591); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dre:796865); (R-DRE-71288)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17486546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC153601.1, AF425745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC153601.1. On or before Feb 21, 2008 this sequence version replaced NP_991304.1, XP_001334598.1., [RefSeq]; Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development., [UniProtKB, UniProtKB]; The spatiotemporal expression pattern of gamt during zebrafish embryogenesis was revealed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7H3", "ec_number_list": "2.1.1.2", "go_molecular_function": "GO:0030731 guanidinoacetate N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0006601 creatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q71N41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71SG7-1", "uniprot_id": "GCNT4_DANRE", "mass": 49928.0, "length": 428, "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4", "gene_name": "gcnt4", "organism": "Zebrafish", "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4", "refseq_ac": "NP_963877", "gene_names_uniprotkb": "gcnt4; si:ch211-129a6.3", "gene_names_refseq": "c2gnt3; gcnt4a; gcnt4; wu:fc31c11", "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; 2.4.1.102", "protein_names_refseq": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; core 2 beta-1,6-N-acetylglucosaminyltransferase 3; glucosaminyl (N-acetyl) transferase 4, core 2, a; glucosaminyl transferase 4, core 2", "tax_id": 7955, "disease": "", "pathway": " (dre:324510); (R-DRE-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075950.1, AF300969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_963877.2., [RefSeq]; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5WWG0;Q6DHL9", "ec_number_list": "2.4.1.102;2.4.1.150;2.4.1.148", "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q71SG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75W95-1", "uniprot_id": "NKX11_DANRE", "mass": 40259.0, "length": 373, "protein_name": "NK1 transcription factor-related protein 1", "gene_name": "nkx1.2lb", "organism": "Zebrafish", "refseq_name": "NK1 transcription factor-related protein 1", "refseq_ac": "NP_998713", "gene_names_uniprotkb": "nkx1.2lb; nkx1.1; sax2", "gene_names_refseq": "nkx1.2lb; sax2; zsax2", "protein_names_uniprotkb": "NK1 transcription factor-related protein 1; Homeodomain protein Sax2; NK1 transcription factor related 2-like,b", "protein_names_refseq": "NK1 transcription factor-related protein 1; homeodomain protein Sax2", "tax_id": 7955, "disease": "", "pathway": " (dre:407077)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15183316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB121758.1, BC129149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB121758.1., [RefSeq]; Expressed in extraocular muscles, in the hindbrain, and interneurons in the spinal cord, [RefSeq, PubMed]; May participate in the energy homeostasis regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q75W95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXA9-1", "uniprot_id": "MUS81_DANRE", "mass": 68017.0, "length": 604, "protein_name": "Structure-specific endonuclease subunit MUS81", "gene_name": "mus81", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mus81", "gene_names_refseq": "", "protein_names_uniprotkb": "Structure-specific endonuclease subunit MUS81; 3.1.22.-; Crossover junction endonuclease MUS81", "protein_names_refseq": "", "tax_id": 7955, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); Marfan syndrome (Disease Ontology:DOID:14323); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:406839); (R-DRE-5693568); (R-DRE-6783310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18413719", "class_list": "", "function": "Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.1.-.-;3.5.2.6;2.7.11.1;3.1.21.-;3.1.4.1;3.1.22.-;5.6.2.1", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006308 DNA catabolic process;GO:0000727 double-strand break repair via break-induced replication;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXB3-1", "uniprot_id": "P3IP1_DANRE", "mass": 28777.0, "length": 263, "protein_name": "Phosphoinositide-3-kinase-interacting protein 1", "gene_name": "pik3ip1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pik3ip1; hgfl; zgc:66482", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoinositide-3-kinase-interacting protein 1; Kringle domain-containing protein HGFL", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:386643)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXB5-1", "uniprot_id": "PF23B_DANRE", "mass": 34989.0, "length": 315, "protein_name": "PHD finger protein 23B", "gene_name": "phf23b", "organism": "Zebrafish", "refseq_name": "PHD finger protein 23B", "refseq_ac": "NP_956138", "gene_names_uniprotkb": "phf23b; zgc:110484; zgc:66469", "gene_names_refseq": "phf23b; wu:fi23e08; zgc:110484; zgc:66469", "protein_names_uniprotkb": "PHD finger protein 23B", "protein_names_refseq": "PHD finger protein 23B", "tax_id": 7955, "disease": "", "pathway": " (dre:100004597)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055673.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055673.1. On Feb 26, 2008 this sequence version replaced XP_001343858.1., [RefSeq]; Acts as a negative regulator of autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q503K5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXE4-1", "uniprot_id": "GOGA5_DANRE", "mass": 84616.0, "length": 760, "protein_name": "Golgin subfamily A member 5", "gene_name": "golga5", "organism": "Zebrafish", "refseq_name": "golgin subfamily A member 5", "refseq_ac": "NP_998576", "gene_names_uniprotkb": "golga5", "gene_names_refseq": "golga5; im:7153094; sb:cb898; wu:fd50h11; zgc:66400", "protein_names_uniprotkb": "Golgin subfamily A member 5; Golgin-84", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 5; golgin subfamily A member 5; golgin-84", "tax_id": 7955, "disease": "", "pathway": " (dre:406720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055639.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055639.1., [RefSeq]; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXF6-1", "uniprot_id": "CREL2_DANRE", "mass": 37603.0, "length": 341, "protein_name": "Cysteine-rich with EGF-like domain protein 2", "gene_name": "creld2", "organism": "Zebrafish", "refseq_name": "cysteine-rich with EGF-like domain protein 2 precursor", "refseq_ac": "NP_956817", "gene_names_uniprotkb": "creld2; zgc:66383", "gene_names_refseq": "creld2; zgc:66383", "protein_names_uniprotkb": "Cysteine-rich with EGF-like domain protein 2", "protein_names_refseq": "cysteine-rich with EGF-like domain protein 2 precursor; cysteine-rich with EGF-like domain protein 2; cysteine-rich with EGF-like domains 2", "tax_id": 7955, "disease": "", "pathway": " (dre:393495)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055626.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055626.1., [RefSeq]; Possible role in neuronal acetylcholine receptor transport., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RFU8", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXK5-1", "uniprot_id": "HUTI_DANRE", "mass": 46904.0, "length": 433, "protein_name": "Probable imidazolonepropionase", "gene_name": "amdhd1", "organism": "Zebrafish", "refseq_name": "probable imidazolonepropionase", "refseq_ac": "NP_001159825", "gene_names_uniprotkb": "amdhd1", "gene_names_refseq": "amdhd1; si:ch73-71d17.1", "protein_names_uniprotkb": "Probable imidazolonepropionase; 3.5.2.7; Amidohydrolase domain-containing protein 1", "protein_names_refseq": "amidohydrolase domain-containing protein 1; probable imidazolonepropionase", "tax_id": 7955, "disease": "", "pathway": " (dre:402826); (R-DRE-70921)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC055559.1. On Nov 16, 2011 this sequence version replaced NP_001159825.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.2.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050480 imidazolonepropionase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXP4-1", "uniprot_id": "SRS1A_DANRE", "mass": 28383.0, "length": 257, "protein_name": "Serine/arginine-rich splicing factor 1A", "gene_name": "srsf1a", "organism": "Zebrafish", "refseq_name": "serine/arginine-rich splicing factor 1A", "refseq_ac": "NP_998180", "gene_names_uniprotkb": "srsf1a; sfrs1a; sfrs1l; zgc:66146", "gene_names_refseq": "sfrs1a; sfrs1l; srsf1a; wu:fb52g10; wu:fb97g12; zgc:66146", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 1A; Splicing factor, arginine/serine-rich 1A; Splicing factor, arginine/serine-rich 1", "protein_names_refseq": "serine/arginine-rich splicing factor 1A; splicing factor, arginine/serine-rich 1, like; splicing factor, arginine/serine-rich 1-like protein 1; splicing factor, arginine/serine-rich 1a", "tax_id": 7955, "disease": "neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0070513); stomach cancer (Disease Ontology:DOID:10534); renovascular hypertension (Disease Ontology:DOID:1591); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:406288)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039714.1, GFIL01039715.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jun 13, 2025 this sequence version replaced XP_005157471.1, NP_998180.1., [RefSeq]; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E5H5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SXP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXP8-1", "uniprot_id": "GMPAB_DANRE", "mass": 47008.0, "length": 422, "protein_name": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B", "gene_name": "gmppab", "organism": "Zebrafish", "refseq_name": "mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B", "refseq_ac": "NP_956791", "gene_names_uniprotkb": "gmppab; zgc:66135", "gene_names_refseq": "gmppab; gmppa; zgc:66135", "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B; GDP-mannose pyrophosphorylase A-B; GTP-mannose-1-phosphate guanylyltransferase alpha-b", "protein_names_refseq": "GDP-mannose pyrophosphorylase A-B; GTP-mannose-1-phosphate guanylyltransferase alpha-b; GTP-mannose-1-phosphate guanylyltransferase apha-B; mannose-1-phosphate guanyltransferase alpha-B; mannose-1-phosphate guanylyltransferase regulatory subunit alpha-B", "tax_id": 7955, "disease": "alacrima, achalasia, and impaired intellectual development syndrome (Disease Ontology:DOID:0112321)", "pathway": " (dre:393469)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33986552;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055506.1. On Jul 6, 2005 this sequence version replaced XP_702289.1., [RefSeq]; Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels (By similarity). One of two paralogs (gmppaa and gmppab) that may have redundant functions (Probable)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SXP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXR1-1", "uniprot_id": "TRBP2_DANRE", "mass": 37435.0, "length": 346, "protein_name": "RISC-loading complex subunit tarbp2", "gene_name": "tarbp2", "organism": "Zebrafish", "refseq_name": "RISC-loading complex subunit tarbp2", "refseq_ac": "NP_956291", "gene_names_uniprotkb": "tarbp2", "gene_names_refseq": "fj51e12; tarbp2; wu:fj51e12; zgc:63778", "protein_names_uniprotkb": "RISC-loading complex subunit tarbp2", "protein_names_refseq": "RISC-loading complex subunit tarbp2", "tax_id": 7955, "disease": "", "pathway": " (dre:336141); (R-DRE-9833482)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055390.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055390.1., [RefSeq]; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Within the RLC/miRLC, dicer1 and tarbp2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto ago2. ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from dicer1 and tarbp2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by dicer1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding;GO:0035197 siRNA binding;GO:0070883 pre-miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006417 regulation of translation;GO:0031054 pre-miRNA processing;GO:0030422 siRNA processing;GO:0046782 regulation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXU0-1", "uniprot_id": "EI3JA_DANRE", "mass": 28673.0, "length": 249, "protein_name": "Eukaryotic translation initiation factor 3 subunit J-A", "gene_name": "eif3ja", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "eif3ja; eif3j; eif3s1a; zgc:63801", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit J-A; Eukaryotic translation initiation factor 3 subunit 1-A; eIF-3-alpha-A; eIF3 p35-A; eIF3j-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:394189); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "18307296;40044042", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SXU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXU7-1", "uniprot_id": "Q7SXU7_DANRE", "mass": 49717.0, "length": 435, "protein_name": "RNA helicase", "gene_name": "ddx39b", "organism": "Zebrafish", "refseq_name": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B", "refseq_ac": "NP_957237", "gene_names_uniprotkb": "ddx39b; Bat1a; bat1; zgc:63773", "gene_names_refseq": "Bat1a; bat1; ddx39b; zgc:63773", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; HLA-B associated transcript 1", "tax_id": 7955, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:393917); (R-DRE-159236); (R-DRE-72163)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16271140;21168434;24269726;26469318;27189481;28252024;29636379;36658633;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055240.1, SRR32588719.1065635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1, EH447839.1, EH457748.1 and EH483474.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KQ04", "ec_number_list": "2.7.7.6;3.6.4.13;5.2.1.8", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7SXU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXV2-1", "uniprot_id": "AEBP2_DANRE", "mass": 45388.0, "length": 415, "protein_name": "Zinc finger protein AEBP2", "gene_name": "aebp2", "organism": "Zebrafish", "refseq_name": "zinc finger protein AEBP2", "refseq_ac": "NP_998659", "gene_names_uniprotkb": "aebp2; si:dkey-158p11.2; wu:fk42f11; wu:fk52h12; zgc:63755", "gene_names_refseq": "aebp2; wu:fk42f11; wu:fk52h12; zgc:63755", "protein_names_uniprotkb": "Zinc finger protein AEBP2; AE-binding protein 2 homolog; Adipocyte enhancer-binding protein 2 homolog", "protein_names_refseq": "AE-binding protein 2 homolog; adipocyte enhancer-binding protein 2 homolog; zinc finger protein AEBP2", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (dre:406815); (R-DRE-212300); (R-DRE-3214841)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055234.1, GFIL01000632.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Nov 19, 2009 this sequence version replaced NP_998659.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LUY9;Q1LUZ0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SXV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXV9-1", "uniprot_id": "CALUB_DANRE", "mass": 37335.0, "length": 315, "protein_name": "Calumenin-B", "gene_name": "calub", "organism": "Zebrafish", "refseq_name": "calumenin-B precursor", "refseq_ac": "NP_957376", "gene_names_uniprotkb": "calub; Calu; fb43g05; sb:eu326; wu:fb43g05; zgc:63741", "gene_names_refseq": "Calu; calub; fb43g05; sb:eu326; wu:fb43g05; zgc:63741", "protein_names_uniprotkb": "Calumenin-B", "protein_names_refseq": "calumenin-B precursor; calumenin-B", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (dre:394057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055227.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055227.1., [RefSeq]; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXW2-1", "uniprot_id": "ZGPAT_DANRE", "mass": 55727.0, "length": 504, "protein_name": "Zinc finger CCCH-type with G patch domain-containing protein", "gene_name": "zgpat", "organism": "Zebrafish", "refseq_name": "zinc finger CCCH-type with G patch domain-containing protein isoform 2", "refseq_ac": "NP_956779", "gene_names_uniprotkb": "zgpat; zgc:63730", "gene_names_refseq": "zgc:63730; zgpat", "protein_names_uniprotkb": "Zinc finger CCCH-type with G patch domain-containing protein", "protein_names_refseq": "zinc finger CCCH-type with G patch domain-containing protein isoform 2; zinc finger CCCH-type with G patch domain-containing protein", "tax_id": 7955, "disease": "", "pathway": " (dre:393457)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1978007.1, SRR32588714.34727290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1., [RefSeq]; Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXW6-1", "uniprot_id": "ARP2A_DANRE", "mass": 44622.0, "length": 394, "protein_name": "Actin-related protein 2-A", "gene_name": "actr2a", "organism": "Zebrafish", "refseq_name": "actin-related protein 2-A", "refseq_ac": "NP_998664", "gene_names_uniprotkb": "actr2a; actr2; arp2a", "gene_names_refseq": "actr2a; actr2; hm:zeh1257; zgc:63719", "protein_names_uniprotkb": "Actin-related protein 2-A; Actin-like protein 2-A", "protein_names_refseq": "ARP2 actin related protein 2a homolog; ARP2 actin-related protein 2 homolog; actin-like protein 2-A; actin-related protein 2-A; actin-related protein 2", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung disease (Disease Ontology:DOID:850)", "pathway": " (dre:406820); (R-DRE-2029482); (R-DRE-3928662); (R-DRE-5663213); (R-DRE-6798695)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055220.1., [RefSeq]; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SXW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXY4-1", "uniprot_id": "DC2L1_DANRE", "mass": 40189.0, "length": 358, "protein_name": "Cytoplasmic dynein 2 light intermediate chain 1", "gene_name": "dync2li1", "organism": "Zebrafish", "refseq_name": "cytoplasmic dynein 2 light intermediate chain 1", "refseq_ac": "NP_956774", "gene_names_uniprotkb": "dync2li1; zgc:63673", "gene_names_refseq": "dync2li1; zgc:63673", "protein_names_uniprotkb": "Cytoplasmic dynein 2 light intermediate chain 1", "protein_names_refseq": "cytoplasmic dynein 2 light intermediate chain 1", "tax_id": 7955, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592)", "pathway": " (dre:393452)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055198.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055198.1., [RefSeq]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005930 axoneme;GO:0097730 non-motile cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0035735 intraciliary transport involved in cilium assembly;GO:0042073 intraciliary transport;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY21-1", "uniprot_id": "TADA3_DANRE", "mass": 48908.0, "length": 429, "protein_name": "Transcriptional adapter 3", "gene_name": "tada3", "organism": "Zebrafish", "refseq_name": "transcriptional adapter 3", "refseq_ac": "NP_956220", "gene_names_uniprotkb": "tada3; ada3; tada3l", "gene_names_refseq": "fa03f04; tada3l; tada3; wu:fa03f04; zgc:63596", "protein_names_uniprotkb": "Transcriptional adapter 3; ADA3 homolog; ADA3-like protein; Transcriptional adapter 3-like", "protein_names_refseq": "ADA3 homolog; ADA3-like protein; transcriptional adapter 3-like; transcriptional adapter 3", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-5689880)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055157.1., [RefSeq]; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SY21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY23-1", "uniprot_id": "AL4A1_DANRE", "mass": 61587.0, "length": 556, "protein_name": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "gene_name": "aldh4a1", "organism": "Zebrafish", "refseq_name": "delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_957452", "gene_names_uniprotkb": "aldh4a1; zgc:63592", "gene_names_refseq": "aldh4a1; zgc:63592", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase", "protein_names_refseq": "L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase; aldehyde dehydrogenase 4A1; aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hyperprolinemia type 2 (Disease Ontology:DOID:0080543)", "pathway": " (dre:394133); (R-DRE-389661); (R-DRE-70688)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055155.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.88", "go_molecular_function": "GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SY23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY29-1", "uniprot_id": "G6PT3_DANRE", "mass": 54040.0, "length": 494, "protein_name": "Glucose-6-phosphate exchanger SLC37A2", "gene_name": "slc37a2", "organism": "Zebrafish", "refseq_name": "glucose-6-phosphate exchanger SLC37A2 isoform 2", "refseq_ac": "NP_001349351", "gene_names_uniprotkb": "slc37a2; blb; unm_t30301; unm_t30913; wu:fv35a12; zgc:63583", "gene_names_refseq": "blb; slc37a2; unm_t30301; unm_t30913; wu:fv35a12; zgc:63583", "protein_names_uniprotkb": "Glucose-6-phosphate exchanger SLC37A2; Solute carrier family 37 member 2", "protein_names_refseq": "blubberblaeschen; glucose-6-phosphate exchanger SLC37A2 isoform 2; glucose-6-phosphate exchanger SLC37A2; solute carrier family 37 (glucose-6-phosphate transporter), member 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; sugar phosphate exchanger 2; unm t30301; unm t30913", "tax_id": 7955, "disease": "", "pathway": " (dre:406287); (R-DRE-70263)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16109975;18339436;26469318;27189481;28694436;30880002;31495570;39366931", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097056.1, SRR26395013.1255178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001349351.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction., [UniProtKB, UniProtKB]; Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V952", "ec_number_list": "", "go_molecular_function": "GO:0061513 glucose 6-phosphate:phosphate antiporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0015760 glucose-6-phosphate transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7SY29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY31-1", "uniprot_id": "PACC1_DANRE", "mass": 34687.0, "length": 298, "protein_name": "Proton-activated chloride channel", "gene_name": "pacc1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pacc1; PAC; fPAC; tmem206; zgc:63579", "gene_names_refseq": "", "protein_names_uniprotkb": "Proton-activated chloride channel; PAC; Transmembrane protein 206; fPAC", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393429)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;31023925", "class_list": "", "function": "Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925). Displays channel activity with distinct kinetic properties compared to the human ortholog channel (PubMed:31023925)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0061797 pH-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SY31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY49-1", "uniprot_id": "CAMKV_DANRE", "mass": 48694.0, "length": 436, "protein_name": "CaM kinase-like vesicle-associated protein", "gene_name": "camkv", "organism": "Zebrafish", "refseq_name": "caM kinase-like vesicle-associated protein", "refseq_ac": "NP_956744", "gene_names_uniprotkb": "camkv; zgc:63506", "gene_names_refseq": "camkvb; camkv; zgc:63506", "protein_names_uniprotkb": "CaM kinase-like vesicle-associated protein; 1G5z", "protein_names_refseq": "1G5z; caM kinase-like vesicle-associated protein; vesicle-associated calmodulin-binding protein", "tax_id": 7955, "disease": "", "pathway": " (dre:393422)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16450396;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055127.1, GFIL01002964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055127.1., [RefSeq]; Does not appear to have detectable kinase activity., [UniProtKB]; The isolation of zebrafish homologue of mammalian 1G5 named 1G5z was reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXP6;Q6STH4", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SY49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY53-1", "uniprot_id": "T23OB_DANRE", "mass": 47422.0, "length": 407, "protein_name": "Tryptophan 2,3-dioxygenase B", "gene_name": "tdo2b", "organism": "Zebrafish", "refseq_name": "tryptophan 2,3-dioxygenase B", "refseq_ac": "NP_956150", "gene_names_uniprotkb": "tdo2b; tdo2l; tdo2; zgc:63488", "gene_names_refseq": "Tdo2; fi30d08; tdo2b; tdo2l; wu:fi30d08; zgc:63488", "protein_names_uniprotkb": "Tryptophan 2,3-dioxygenase B; 1.13.11.11; TDO-B; TO-B; TRPO-B; Tryptamin 2,3-dioxygenase B; Tryptophan oxygenase B; Tryptophan pyrrolase B; Tryptophanase B", "protein_names_refseq": "tryptophan 2,3-dioxygenase B; tryptophan 2,3-dioxygenase, like", "tax_id": 7955, "disease": "familial hypertryptophanemia (Disease Ontology:DOID:0111703); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:334082)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055123.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055123.1. On Jul 6, 2005 this sequence version replaced XP_702144.1., [RefSeq]; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.11", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0051289 protein homotetramerization;GO:0019442 L-tryptophan catabolic process to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SY53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY54-1", "uniprot_id": "AT2L1_DANRE", "mass": 54735.0, "length": 492, "protein_name": "Ethanolamine-phosphate phospho-lyase", "gene_name": "etnppl", "organism": "Zebrafish", "refseq_name": "ethanolamine-phosphate phospho-lyase", "refseq_ac": "NP_956743", "gene_names_uniprotkb": "etnppl; agxt2l1; zgc:63486", "gene_names_refseq": "agxt2l1; etnppl; zgc:63486", "protein_names_uniprotkb": "Ethanolamine-phosphate phospho-lyase; 4.2.3.2; Alanine--glyoxylate aminotransferase 2-like 1", "protein_names_refseq": "alanine--glyoxylate aminotransferase 2-like 1; ethanolamine-phosphate phospho-lyase", "tax_id": 7955, "disease": "", "pathway": " (dre:393421); (R-DRE-1483213)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055122.1., [RefSeq]; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.3.2", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0050459 ethanolamine-phosphate phospho-lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SY54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYC9-1", "uniprot_id": "CTL2_DANRE", "mass": 79178.0, "length": 697, "protein_name": "Choline transporter-like protein 2", "gene_name": "slc44a2; zgc:63569", "organism": "Zebrafish", "refseq_name": "choline transporter-like protein 2 isoform 1", "refseq_ac": "NP_942572", "gene_names_uniprotkb": "slc44a2; zgc:63569; Ctl2; cb39; ctl2; sb:cb39; slc44a2; zgc:63569", "gene_names_refseq": "Ctl2; cb39; sb:cb39; slc44a2; zgc:63569", "protein_names_uniprotkb": "Choline transporter-like protein 2; Solute carrier family 44 member 2", "protein_names_refseq": "choline transporter-like protein 2 isoform 1; choline transporter-like protein 2; solute carrier family 44 member 2", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-1483191); (R-DRE-6798163); (R-DRE-6798695); (R-DRE-9958517)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01047048.1, GDQH01006424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On or before Jun 23, 2025 this sequence version replaced XP_073792218.1, NP_942572.1., [RefSeq]; Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter, mainly in mitochondria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7SYC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0D0-1", "uniprot_id": "QKIA_DANRE", "mass": 37934.0, "length": 341, "protein_name": "Protein quaking-A", "gene_name": "qkia", "organism": "Zebrafish", "refseq_name": "protein quaking-A", "refseq_ac": "NP_571299", "gene_names_uniprotkb": "qkia; cb344; fb44d06; fc32f06; qk1; qkA; qk; wu:fb44d06; wu:fc32f06; zqk-1; zqk1; zqk", "gene_names_refseq": "cb344; fb44d06; fc32f06; qk1; qkA; qkia; qk; wu:fb44d06; wu:fc32f06; zqk-1; zqk1; zqk", "protein_names_uniprotkb": "Protein quaking-A; zqk", "protein_names_refseq": "protein quaking-A; quaking a; quaking", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:30471)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21447554;26727370;28867488;9486543", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U62134.1, BC065667.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U62134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development., [RefSeq, PubMed]; Qkia is an ancestral paralog of the single tetrapod Qk gene that was likely lost during the fin-to-limb transition. qkia is not expressed in the progenitor domains of the central nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:21447554, PubMed:28867488). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development (By similarity). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons (By similarity). CircRNAs are produced by back-splicing circularization of pre-mRNAs (By similarity). Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity). Acts as an important regulator of muscle development: required during early skeletal myofibril formation by regulating the accumulation of the muscle-specific tropomyosin-3 (tpm3) transcripts (PubMed:28867488)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; This work uncovers a Quaking/Tpm3 pathway controlling de novo myofibril assembly., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O42476;Q6PHD0", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0006417 regulation of translation;GO:0045650 negative regulation of macrophage differentiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P0D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6L8F3-1", "uniprot_id": "S39A6_DANRE", "mass": 83030.0, "length": 742, "protein_name": "Zinc transporter ZIP6", "gene_name": "slc39a6", "organism": "Zebrafish", "refseq_name": "zinc transporter ZIP6", "refseq_ac": "NP_001001591", "gene_names_uniprotkb": "slc39a6; ZIP-6; liv1; wu:fc25a09; zip6", "gene_names_refseq": "ZIP-6; liv1; slc39a6; wu:fc25a09", "protein_names_uniprotkb": "Zinc transporter ZIP6; Estrogen-regulated protein LIV-1; Solute carrier family 39 member 6; ZIP-6; Zrt- and Irt-like protein 6", "protein_names_refseq": "ZIP6; estrogen-regulated protein LIV-1; solute carrier family 39 (zinc transporter), member 6; zinc transporter ZIP6; zrt- and Irt-like protein 6", "tax_id": 7955, "disease": "", "pathway": " (dre:324303); (R-DRE-442380)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15129296;23594743;30851936", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB126260.1, BC162757.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB126260.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT)., [UniProtKB, PubMed, PubMed]; Results establish a molecular link between STAT3, LIV1 and Snail in epithelial-mesenchymal transition in gastrula organizer; LIV1 is essential for the nuclear localization of zinc-finger protein Snail, [RefSeq, PubMed]; The slc39a6 - null mutant zebrafish developed normally during gastrulation. Loss of slc39a6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels. And the slc39a6 deficiency increases caspase-related cell apoptosis in both zebrafish cells and human T cells., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006829 zinc ion transport;GO:0050852 T cell receptor signaling pathway;GO:0042074 cell migration involved in gastrulation;GO:0001837 epithelial to mesenchymal transition;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6L8F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90275-1", "uniprot_id": "CADH2_DANRE", "mass": 98990.0, "length": 893, "protein_name": "Cadherin-2", "gene_name": "cdh2", "organism": "Zebrafish", "refseq_name": "cadherin-2 precursor", "refseq_ac": "NP_571156", "gene_names_uniprotkb": "cdh2; pac", "gene_names_refseq": "bib; cdh2; glo; lyr; ncad; pac; wu:fb47h04", "protein_names_uniprotkb": "Cadherin-2; N-cadherin; Neural cadherin; Parachute; ZNCAD", "protein_names_refseq": "cadherin 2, neuronal; cadherin-2 precursor; cadherin-2; glass onion; labyrinth; n-cadherin; neural cadherin; parachute", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); agenesis of corpus callosum, cardiac, ocular, and genital syndrome (Disease Ontology:DOID:0080948); arrhythmogenic right ventricular dysplasia 14 (Disease Ontology:DOID:0080959); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (dre:30291); (R-DRE-381426); (R-DRE-418990); (R-DRE-525793); (R-DRE-8957275)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10456847;12020083;12091300;12972001;14648850;21115806;22184198;30361324;33004519;40044042;7873785", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF430842.1, AF418565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT827862.10, AF418565.1 and CR759908.12. On Nov 1, 2008 this sequence version replaced NP_571156.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (PubMed:12091300). Required for normal neural tube morphogenesis (PubMed:12091300, PubMed:21115806). Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain (PubMed:14648850, PubMed:21115806). Functions with protocadherin pcdh19 to coordinate cell adhesion and cell movements during neurulation (PubMed:21115806). pcdh19 shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex (PubMed:21115806, PubMed:22184198, PubMed:33004519). Contributes to neural progenitor cell patterning by promoting homophilic cell interactions (PubMed:33004519). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8UVQ7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0048752 semicircular canal morphogenesis;GO:0097475 motor neuron migration;GO:0048332 mesoderm morphogenesis;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q90275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9N1-1", "uniprot_id": "DAP1A_DANRE", "mass": 11367.0, "length": 105, "protein_name": "Death-associated protein 1 homolog", "gene_name": "dap", "organism": "Zebrafish", "refseq_name": "death-associated protein 1 homolog", "refseq_ac": "NP_571647", "gene_names_uniprotkb": "dap", "gene_names_refseq": "DAP-1A; DAP-1; dap1a; dap; wu:fa16h08; wu:fc06d11", "protein_names_uniprotkb": "Death-associated protein 1 homolog; DAP-1A; DAP-1; Death-associated protein 1A", "protein_names_refseq": "bZ1F1.9.1 (death associated protein 1a); bZ1F1.9.2 (death associated protein 1a); death-associated protein 1 homolog; death-associated protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:58093)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10917738;23594743;36653451", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049052.1, EH484647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049052.1., [RefSeq]; Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36653451). Acts via its association with eiF5a (eif5a and eif5a2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (PubMed:36653451). Involved in ribosome hibernation in the mature egg by preventing mRNA translation, leading to ribosome inactivation (PubMed:36653451). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (PubMed:36653451). Compared to dap1b, binds and inactivates ribosomes less efficiently (PubMed:36653451)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "", "go_biological_process": "GO:0097190 apoptotic signaling pathway;GO:0010507 negative regulation of autophagy;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9I9N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XJA5-1", "uniprot_id": "HABP4_DANRE", "mass": 38553.0, "length": 347, "protein_name": "Intracellular hyaluronan-binding protein 4", "gene_name": "habp4", "organism": "Zebrafish", "refseq_name": "intracellular hyaluronan-binding protein 4", "refseq_ac": "NP_001006022", "gene_names_uniprotkb": "habp4; zgc:103482", "gene_names_refseq": "habp4; zgc:103482", "protein_names_uniprotkb": "Intracellular hyaluronan-binding protein 4", "protein_names_refseq": "intracellular hyaluronan-binding protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:450001); (R-DRE-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;36653451", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083399.1, BC164158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA898399 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083399.1., [RefSeq]; Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36653451). Acts via its association with eef2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (PubMed:36653451). Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization (PubMed:36653451). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (PubMed:36653451)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0R085", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0061770 translation elongation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0015030 Cajal body", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0045948 positive regulation of translational initiation;GO:0141014 ribosome hibernation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XJA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U3J8-1", "uniprot_id": "LTV1_DANRE", "mass": 54209.0, "length": 469, "protein_name": "Protein LTV1 homolog", "gene_name": "ltv1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ltv1; c6orf93; zgc:103432", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein LTV1 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "inflammatory poikiloderma with hair abnormalities and acral keratoses (Disease Ontology:DOID:0070510)", "pathway": " (dre:436587); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15256591;26469318;34692673", "class_list": "", "function": "Essential for ribosome biogenesis (PubMed:34692673). Involved in organogenesis of digestive system and definitive hematopoiesis (PubMed:34692673)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DRP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0055123 digestive system development;GO:0060216 definitive hemopoiesis;GO:0060536 cartilage morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U3J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G9G127-1", "uniprot_id": "NINL_DANRE", "mass": 149886.0, "length": 1303, "protein_name": "Ninein-like protein", "gene_name": "Ninl; ninl", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ninl; ninl", "gene_names_refseq": "", "protein_names_uniprotkb": "Ninein-like protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:561921)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;26469318;26485514;26485645;27189481", "class_list": "", "function": "Required for the intracellular transport of organelles and vesicles, and is essential for the photoreceptor's outer segments formation, maintenance and function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0036064 ciliary basal body", "go_biological_process": "GO:0035845 photoreceptor cell outer segment organization;GO:0042462 eye photoreceptor cell development;GO:0034454 microtubule anchoring at centrosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G9G127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QEA3-1", "uniprot_id": "FIGL2_DANRE", "mass": 73514.0, "length": 684, "protein_name": "Fidgetin-like protein 2", "gene_name": "fignl2", "organism": "Zebrafish", "refseq_name": "fidgetin-like protein 2", "refseq_ac": "NP_001201837", "gene_names_uniprotkb": "fignl2; fc13c02; si:dkey-157g16.6; wu:fc13c02", "gene_names_refseq": "fc13c02; fignl2; si:dkey-157g16.6; wu:fc13c02", "protein_names_uniprotkb": "Fidgetin-like protein 2; 3.6.4.-", "protein_names_refseq": "fidgetin-like protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:561837)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;33069857;33585441", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1312004.1, SRR32588724.2485855.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476775, SAMEA4476810 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On May 25, 2011 this sequence version replaced XP_690329.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were predicted based on zebrafish transcript alignments and on homologous protein alignment with human NP_001013712.4., [RefSeq]; Microtubule-severing enzyme that negatively regulates cell migration and wound healing. In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (By similarity). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (By similarity). Contributes to proper cell branching during endothelial and neuronal development (PubMed:33585441)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NZ11", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0051013 microtubule severing;GO:0030336 negative regulation of cell migration;GO:0001763 morphogenesis of a branching structure;GO:0048681 negative regulation of axon regeneration;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QEA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QHT9-1", "uniprot_id": "PERP_DANRE", "mass": 21088.0, "length": 185, "protein_name": "p53 apoptosis effector related to PMP-22", "gene_name": "perp", "organism": "Zebrafish", "refseq_name": "p53 apoptosis effector related to PMP-22", "refseq_ac": "NP_001243136", "gene_names_uniprotkb": "perp; fk24g11", "gene_names_refseq": "fk24g11; perp; wu:fk24g11", "protein_names_uniprotkb": "p53 apoptosis effector related to PMP-22", "protein_names_refseq": "PERP, TP53 apoptosis effector; p53 apoptosis effector related to PMP-22", "tax_id": 7955, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112011)", "pathway": " (dre:494479); (R-DRE-6809371)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15529176;23594743;27834691", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.70657.1, GFIL01029966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB795440.1 and JBMGRA010000013.1. On or before Jan 14, 2012 this sequence version replaced XP_003199730.1, XP_686659.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of intercellular desmosome junctions (By similarity). Positively regulates apoptosis in the early-stage embryo in response to UV irradiation, this is partially dependent on tp53 activation (PubMed:15529176). Required for the survival of cell populations in the developing notochord and skin, therefore required for normal embryogenesis beyond 30 hpf (PubMed:15529176). Acts as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (PubMed:27834691)., [UniProtKB, PubMed, PubMed, UniProtKB]; In contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NZE2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0009411 response to UV;GO:0042981 regulation of apoptotic process;GO:1902262 apoptotic process involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QHT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1LXR6-1", "uniprot_id": "DZAN1_DANRE", "mass": 81034.0, "length": 752, "protein_name": "Double zinc ribbon and ankyrin repeat-containing protein 1", "gene_name": "dzank1", "organism": "Zebrafish", "refseq_name": "double zinc ribbon and ankyrin repeat-containing protein 1", "refseq_ac": "NP_001038395", "gene_names_uniprotkb": "dzank1; wu:fj19d07; zgc:123116", "gene_names_refseq": "dzank1; wu:fj19d07; zgc:123116", "protein_names_uniprotkb": "Double zinc ribbon and ankyrin repeat-containing protein 1", "protein_names_refseq": "double zinc ribbon and ankyrin repeat-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:407652)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;23594743;26485514", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009111.1, SRR32588730.12632854.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000022.1. On Jun 25, 2025 this sequence version replaced NP_001038395.1., [RefSeq]; Our results support a model in which the NINL-DZANK1 protein module is involved in the proper assembly and folding of the cytoplasmic dynein 1 motor complex in photoreceptor cells, a process essential for outer segment formation and function Publication Status: Online-Only, [RefSeq, PubMed]; Required for the intracellular transport of organelles and vesicles, and is essential for the photoreceptor's outer segments formation, maintenance and function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N9L8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0032386 regulation of intracellular transport;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1LXR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYB2-1", "uniprot_id": "THOC1_DANRE", "mass": 74998.0, "length": 655, "protein_name": "THO complex subunit 1", "gene_name": "thoc1", "organism": "Zebrafish", "refseq_name": "THO complex subunit 1", "refseq_ac": "NP_958481", "gene_names_uniprotkb": "thoc1", "gene_names_refseq": "Tho1; p84; thoc1", "protein_names_uniprotkb": "THO complex subunit 1", "protein_names_refseq": "THO complex subunit 1", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 86 (Disease Ontology:DOID:0070610)", "pathway": " (dre:373077); (R-DRE-159236)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;32776944;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054938.1. On Jul 6, 2005 this sequence version replaced XP_702495.1., [RefSeq]; Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (By similarity). Required for efficient export of polyadenylated RNA (By similarity). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (By similarity). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (By similarity). Regulates transcriptional elongation of a subset of genes (By similarity). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (PubMed:32776944)., [UniProtKB, UniProtKB, PubMed]; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Essential for early embryonic development. Required for normal gene expression during postnatal testis development., [UniProtKB, UniProtKB]; THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7SYB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5DE31-1", "uniprot_id": "YBOX1_DANRE", "mass": 35012.0, "length": 310, "protein_name": "Y-box-binding protein 1", "gene_name": "ybx1", "organism": "Zebrafish", "refseq_name": "Y-box-binding protein 1 isoform 1", "refseq_ac": "NP_001119929", "gene_names_uniprotkb": "ybx1", "gene_names_refseq": "YB-1; hm:zeh0308; nsep1; wu:fb01g10; wu:fb08c05; wu:fb16e10; wu:fj26c09; yb1; ybx1; zfY1; zgc:85599", "protein_names_uniprotkb": "Y-box-binding protein 1; Y-box transcription factor; YB-1; ZfY1", "protein_names_refseq": "Y-box transcription factor; Y-box-binding protein 1 isoform 1; nuclease sensitive element binding protein 1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:795398); (R-DRE-72163); (R-DRE-72165); (R-DRE-72203); (R-DRE-877300); (R-DRE-9770562)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10446383;23594743;30135188;31399345;37471641;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050156.1, GFIL01043868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (PubMed:30135188, PubMed:31399345). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:31399345). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay (PubMed:31399345). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (PubMed:31399345). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (PubMed:30135188). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs. Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Proteomic analysis of zebrafish folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian folliculogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IK84;A1A605;F1RB19;O93584;Q6NSP3;Q7ZU03", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0008327 methyl-CpG binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000932 P-body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0048255 mRNA stabilization;GO:0008544 epidermis development;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B5DE31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F8W463-1", "uniprot_id": "P2X4A_DANRE", "mass": 43989.0, "length": 389, "protein_name": "P2X purinoceptor 4a", "gene_name": "p2rx4a", "organism": "Zebrafish", "refseq_name": "P2X purinoceptor 4a", "refseq_ac": "NP_705939", "gene_names_uniprotkb": "p2rx4a; p2rx4; p2x4; wu:fi03f02", "gene_names_refseq": "p2rx4a; p2rx4; p2x4; wu:fi03f02", "protein_names_uniprotkb": "P2X purinoceptor 4a", "protein_names_refseq": "ATP-gated ion channel; P2X purinoceptor 4a; etID14865.21; zP2X4.1", "tax_id": 7955, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:259258)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12127972;19641588;22535247;23594743;28332633", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF317643.1, BC066495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF317643.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (By similarity). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (PubMed:28332633). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Could also function as an ATP-gated cation channel of lysosomal membranes., [UniProtKB, UniProtKB]; Cloning and characterization of zebrafish P2X4 and P2X5., [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYR1;Q98TZ0", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0098794 postsynapse;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006812 monoatomic cation transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "F8W463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RHR0-1", "uniprot_id": "PARP1_DANRE", "mass": 112776.0, "length": 1013, "protein_name": "Poly [ADP-ribose] polymerase 1", "gene_name": "parp1", "organism": "Zebrafish", "refseq_name": "poly [ADP-ribose] polymerase 1", "refseq_ac": "NP_001038407", "gene_names_uniprotkb": "parp1; ADPRT 1; ARTD1; PARP-1; si:dkey-206f10.3; wu:fc60f12; zgc:110092", "gene_names_refseq": "ADPRT 1; ARTD1; PARP-1; parp1; si:dkey-206f10.3; wu:fc60f12; zgc:110092", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly [ADP-ribose] polymerase; poly[ADP-ribose] synthase 1; protein poly-ADP-ribosyltransferase PARP1", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); middle cerebral artery infarction (Disease Ontology:DOID:3525); autoimmune disease (Disease Ontology:DOID:417); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); stomach carcinoma (Disease Ontology:DOID:5517); congestive heart failure (Disease Ontology:DOID:6000); arthritis (Disease Ontology:DOID:848); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470)", "pathway": " (dre:560788); (R-DRE-110362); (R-DRE-3108214); (R-DRE-5685939); (R-DRE-5696394); (R-DRE-5696395); (R-DRE-5696400)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "23594743;34798058;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01017236.1, GFIL01029491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Sep 1, 2006 this sequence version replaced XP_689279.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Parp1 promotes sleep, which enhances DNA repair in neurons., [RefSeq, PubMed]; Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:34798058). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as hpf1 and nmnat1 (By similarity). Following interaction with hpf1, catalyzes serine ADP-ribosylation of target proteins; hpf1 confers serine specificity by completing the parp1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with hpf1 (By similarity). Following interaction with nmnat1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; nmnat1 confers glutamate and aspartate specificity (By similarity). Parp1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits hpf1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair. Mediates the poly-ADP-ribosylation of a number of proteins. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (By similarity). Parp1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (PubMed:34798058). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (By similarity). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II. Acts both as a positive and negative regulator of transcription elongation, depending on the context (By similarity). Poly-ADP-ribose chains generated by parp1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos. Also acts as a negative regulator of the cGAS-STING pathway by mediating poly-ADP-ribosylation and inactivation of cgas. Acts as a negative regulator of adipogenesis by catalyzing poly ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q499A8", "ec_number_list": "3.1.11.2;3.1.21.-;2.7.7.7;3.2.1.143;2.4.2.-;2.3.2.27;3.1.-.-;2.4.2.30;4.2.99.18;4.2.99.-;3.6.4.-;5.6.2.4;2.3.2.-", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0070213 protein auto-ADP-ribosylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RHR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5TZH6-1", "uniprot_id": "Q5TZH6_DANRE", "mass": 20512.0, "length": 186, "protein_name": "Peptide-methionine (R)-S-oxide reductase", "gene_name": "msrb3", "organism": "Zebrafish", "refseq_name": "methionine-R-sulfoxide reductase B3 isoform 2", "refseq_ac": "NP_001002094", "gene_names_uniprotkb": "msrb3; wu:fc07g04; zgc:86909", "gene_names_refseq": "msrb3; wu:fc07g04; zgc:86909", "protein_names_uniprotkb": "Peptide-methionine (R)-S-oxide reductase; 1.8.4.12", "protein_names_refseq": "methionine-R-sulfoxide reductase B3 isoform 2", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 74 (Disease Ontology:DOID:0110523)", "pathway": " (dre:415184); (R-DRE-5676934)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15520368;19084604;20830285;25840431;26048245;26469318;26505252;26719797", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026989.1, SRR32588733.1084025.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On or before Feb 23, 2016 this sequence version replaced XP_005164678.1, NP_001002094.1. Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments., [RefSeq]; Data show that methionine sulfoxide reductase B3 (msrb3) is instrumental for auditory system development in zebrafish., [RefSeq, PubMed]; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1MZV0;A0AC58J6A9;A0AC58J6B8;Q5TZH7", "ec_number_list": "1.8.4.14;1.8.4.12", "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0048839 inner ear development;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5TZH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RHR9-1", "uniprot_id": "Q5RHR9_DANRE", "mass": 93303.0, "length": 825, "protein_name": "Dynamin-2", "gene_name": "dnm3a", "organism": "Zebrafish", "refseq_name": "dynamin 3a", "refseq_ac": "NP_001121996", "gene_names_uniprotkb": "dnm3a; dnm3; si:dkey-19f21.3", "gene_names_refseq": "dnm3a; dnm3; si:dkey-19f21.3", "protein_names_uniprotkb": "Dynamin-2; 3.6.5.5", "protein_names_refseq": "dynamin 3a; dynamin 3", "tax_id": 7955, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (dre:557996)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23418470;24643020;25792259;26469318;27189481;28252024;29487295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.21313254.1, SRR32588714.6622620.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000020.1. On Jul 31, 2008 this sequence version replaced XP_686251.3., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NHL4;R4GE56", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005874 microtubule;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density;GO:0055037 recycling endosome", "go_biological_process": "GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5RHR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU42-1", "uniprot_id": "OLA1_DANRE", "mass": 44902.0, "length": 396, "protein_name": "Obg-like ATPase 1", "gene_name": "ola1", "organism": "Zebrafish", "refseq_name": "obg-like ATPase 1 isoform 1", "refseq_ac": "NP_999865", "gene_names_uniprotkb": "ola1; OLA1; fe36h01; wu:fc66b09; wu:fe36h01; wu:fk82a02; zgc:55768; zgc:85691", "gene_names_refseq": "fe36h01; ola1; wu:fc66b09; wu:fe36h01; wu:fk82a02; zgc:55768; zgc:85691", "protein_names_uniprotkb": "Obg-like ATPase 1", "protein_names_refseq": "obg-like ATPase 1 isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:326864); (R-DRE-114608)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;28252024;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC051155.1, SRR26395013.945930.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH578941.1, EH542806.1, EH611446.1 and JBMGRA010000006.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZU42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV43-1", "uniprot_id": "TOLIP_DANRE", "mass": 30424.0, "length": 276, "protein_name": "Toll-interacting protein", "gene_name": "tollip", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tollip; fk22a02; im:7145391; wu:fk22a02; zgc:76985", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-interacting protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:336876); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18039395;26110841;27330905;28252024;35506194;40044042", "class_list": "", "function": "Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYL4", "ec_number_list": "", "go_molecular_function": "GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006914 autophagy;GO:0016310 phosphorylation;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7ZV43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW24-1", "uniprot_id": "ALG11_DANRE", "mass": 56623.0, "length": 500, "protein_name": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase", "gene_name": "alg11", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "alg11; fj04e04; si:dkey-1h24.5; wu:fj04e04", "gene_names_refseq": "", "protein_names_uniprotkb": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; 2.4.1.131; Asparagine-linked glycosylation protein 11 homolog; Glycolipid 2-alpha-mannosyltransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "congenital disorder of glycosylation Ip (Disease Ontology:DOID:0080567)", "pathway": " (dre:407614)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.131", "go_molecular_function": "GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZW24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803T2-1", "uniprot_id": "STRP1_DANRE", "mass": 93600.0, "length": 813, "protein_name": "Striatin-interacting protein 1 homolog", "gene_name": "strip1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "strip1; fam40a; wu:fa11b02; zgc:56721", "gene_names_refseq": "", "protein_names_uniprotkb": "Striatin-interacting protein 1 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:568805)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16109975;18307296;25010986;27189481;28252024;35314028;36126741", "class_list": "", "function": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0090443 FAR/SIN/STRIPAK complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0060047 heart contraction;GO:0007010 cytoskeleton organization;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q803T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWF0-1", "uniprot_id": "RAE1L_DANRE", "mass": 41051.0, "length": 368, "protein_name": "mRNA export factor", "gene_name": "rae1", "organism": "Zebrafish", "refseq_name": "mRNA export factor", "refseq_ac": "NP_957292", "gene_names_uniprotkb": "rae1; mrnp41; zgc:56449; zgc:77723", "gene_names_refseq": "rae1; zgc:56449; zgc:77723", "protein_names_uniprotkb": "mRNA export factor; Rae1 protein homolog; mRNA-associated protein mrnp 41", "protein_names_refseq": "RAE1 RNA export 1 homolog; mRNA export factor; mRNA-associated protein mrnp 41; rae1 protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:393973); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049445.1, BC065853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049445.1. On or before Aug 24, 2007 this sequence version replaced XP_001337757.1, XP_001337831.1., [RefSeq]; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P037", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0097431 mitotic spindle pole;GO:0000922 spindle pole;GO:0005635 nuclear envelope", "go_biological_process": "GO:0051301 cell division;GO:0060236 regulation of mitotic spindle organization;GO:0006405 RNA export from nucleus;GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802G7-1", "uniprot_id": "SELM_DANRE", "mass": 17172.0, "length": 151, "protein_name": "Selenoprotein M", "gene_name": "Selenom; selenom", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Selenom; selenom; cb693; fc13f12; selm; sepm; wu:fc13f12; zgc:103431", "gene_names_refseq": "", "protein_names_uniprotkb": "Selenoprotein M; SePM; SelM", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:352913)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12915322;22479358;25064324;26469318;27189481;27645994;38042913", "class_list": "", "function": "May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJC8", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q802G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUK7-1", "uniprot_id": "WAC_DANRE", "mass": 60592.0, "length": 558, "protein_name": "WW domain-containing adapter protein with coiled-coil", "gene_name": "waca", "organism": "Zebrafish", "refseq_name": "WW domain-containing adapter protein with coiled-coil isoform 1", "refseq_ac": "NP_955954", "gene_names_uniprotkb": "waca; wac; wu:fc13f04; wu:fj68f01; zgc:55755", "gene_names_refseq": "waca; wac; wu:fc13f04; wu:fj68f01; zgc:55755", "protein_names_uniprotkb": "WW domain-containing adapter protein with coiled-coil", "protein_names_refseq": "WW domain-containing adapter protein with coiled-coil isoform 1; WW domain-containing adapter protein with coiled-coil; WW domain-containing adapter with a coiled-coil region", "tax_id": 7955, "disease": "DeSanto-Shinawi syndrome (Disease Ontology:DOID:0081126)", "pathway": " (dre:323904)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01015321.1, AY576994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Jun 10, 2025 this sequence version replaced XP_009304863.2, NP_955954.1., [RefSeq]; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PUS1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZUK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVR6-1", "uniprot_id": "MYNN_DANRE", "mass": 91120.0, "length": 810, "protein_name": "Myoneurin", "gene_name": "mynn", "organism": "Zebrafish", "refseq_name": "myoneurin", "refseq_ac": "NP_956062", "gene_names_uniprotkb": "mynn; wu:fd15c04; zgc:55724", "gene_names_refseq": "mynn; wu:fd15c04; zgc:55724", "protein_names_uniprotkb": "Myoneurin", "protein_names_refseq": "myoneurin", "tax_id": 7955, "disease": "", "pathway": " (dre:327167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.1424436.1, SRR26395014.732116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Jun 18, 2025 this sequence version replaced XP_073796130.1, NP_956062.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production;GO:0030510 regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q800G5-1", "uniprot_id": "MXE_DANRE", "mass": 70395.0, "length": 625, "protein_name": "Interferon-induced GTP-binding protein MxE", "gene_name": "mxe", "organism": "Zebrafish", "refseq_name": "interferon-induced GTP-binding protein MxE", "refseq_ac": "NP_878287", "gene_names_uniprotkb": "mxe; wu:fj93f01; zgc:111895", "gene_names_refseq": "mxe; wu:fj93f01; zgc:111895", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein MxE; IFN-inducible antiviral protein MxE; Interferon-inducible MxE protein", "protein_names_refseq": "IFN-inducible antiviral protein MxE; interferon-induced GTP-binding protein MxE; interferon-inducible MxE protein", "tax_id": 7955, "disease": "", "pathway": " (dre:337663)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12869211", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ544827.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ544827.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0051607 defense response to virus;GO:0009615 response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q800G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVR8-1", "uniprot_id": "ESRP2_DANRE", "mass": 80830.0, "length": 736, "protein_name": "Epithelial splicing regulatory protein 2", "gene_name": "esrp2", "organism": "Zebrafish", "refseq_name": "epithelial splicing regulatory protein 2", "refseq_ac": "NP_954966", "gene_names_uniprotkb": "esrp2; cb404; fa07a06; rbm35ba; rbm35b; sb:cb404; zgc:77254", "gene_names_refseq": "cb404; esrp2; fa07a06; rbm35ba; rbm35b; sb:cb404; zgc:77254", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B", "protein_names_refseq": "RNA-binding motif protein 35B; RNA-binding protein 35B-A; RNA-binding protein 35B; epithelial splicing regulatory protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:572992)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476736, SAMEA4476762 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045439.1. On Dec 19, 2007 this sequence version replaced XP_686822.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0A9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:1905748 hard palate morphogenesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU29-1", "uniprot_id": "NUP93_DANRE", "mass": 93149.0, "length": 820, "protein_name": "Nuclear pore complex protein Nup93", "gene_name": "dye; nup93", "organism": "Zebrafish", "refseq_name": "nuclear pore complex protein Nup93", "refseq_ac": "NP_571056", "gene_names_uniprotkb": "dye; nup93; dye", "gene_names_refseq": "dye; nup93", "protein_names_uniprotkb": "Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Dead eye protein; Nucleoporin Nup93", "protein_names_refseq": "93 kDa nucleoporin; dead eye protein; nuclear pore complex protein Nup93; nucleoporin Nup93", "tax_id": 7955, "disease": "nephrotic syndrome type 12 (Disease Ontology:DOID:0080387)", "pathway": " (dre:30172); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638); (R-DRE-9615933)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "40044042;8985183", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044466.1. On or before Jul 6, 2005 this sequence version replaced XP_701953.1, NP_571056.1., [RefSeq]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P79740;Q9DGQ8", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0051292 nuclear pore complex assembly;GO:0006606 protein import into nucleus;GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZU29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVN4-1", "uniprot_id": "ZD18B_DANRE", "mass": 42712.0, "length": 388, "protein_name": "Palmitoyltransferase ZDHHC18-B", "gene_name": "zdhhc18b", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC18-B", "refseq_ac": "NP_999872", "gene_names_uniprotkb": "zdhhc18b; fi45c03; wu:fi45c03; wu:fj48h10; zgc:55843", "gene_names_refseq": "fi45c03; wu:fi45c03; wu:fj48h10; zdhhc18b; zgc:55843", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC18-B; 2.3.1.225; Zinc finger DHHC domain-containing protein 18-B", "protein_names_refseq": "palmitoyltransferase ZDHHC18-B; palmitoyltransferase ZDHHC18b; zinc finger DHHC domain-containing protein 18-B; zinc finger DHHC-type containing 18b; zinc finger DHHC-type palmitoyltransferase 18b; zinc finger, DHHC domain containing 14", "tax_id": 7955, "disease": "", "pathway": " (dre:334383)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045475.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZVN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW47-1", "uniprot_id": "STAU2_DANRE", "mass": 66504.0, "length": 606, "protein_name": "Double-stranded RNA-binding protein Staufen homolog 2", "gene_name": "stau2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "stau2; zgc:55287", "gene_names_refseq": "", "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (dre:393899)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16513105;27189481;28252024;36414621", "class_list": "", "function": "RNA-binding protein required for the microtubule-dependent transport of RNAs within polarized cell types., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003725 double-stranded RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0032839 dendrite cytoplasm;GO:0043005 neuron projection", "go_biological_process": "GO:0007281 germ cell development;GO:0035418 protein localization to synapse;GO:0008354 germ cell migration;GO:0008298 intracellular mRNA localization;GO:0098964 anterograde dendritic transport of messenger ribonucleoprotein complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZW47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW86-1", "uniprot_id": "CWC27_DANRE", "mass": 53481.0, "length": 470, "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "cwc27", "organism": "Zebrafish", "refseq_name": "spliceosome-associated protein CWC27 homolog", "refseq_ac": "NP_957397", "gene_names_uniprotkb": "cwc27; Sdccag10; sdccag10; zgc:56702", "gene_names_refseq": "Sdccag10; cwc27; zgc:56702", "protein_names_uniprotkb": "Spliceosome-associated protein CWC27 homolog; PPIase CWC27; Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog", "protein_names_refseq": "CWC27 spliceosome-associated protein homolog; PPIase CWC27; PPIase SDCCAG10; peptidyl-prolyl cis-trans isomerase CWC27 homolog; peptidyl-prolyl cis-trans isomerase SDCCAG10; probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog; spliceosome-associated protein CWC27 homolog", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:394078)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049533.1., [RefSeq]; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071005 U2-type precatalytic spliceosome;GO:0005634 nucleus", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZW86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZC5-1", "uniprot_id": "NDC1_DANRE", "mass": 74441.0, "length": 671, "protein_name": "Nucleoporin NDC1", "gene_name": "ndc1", "organism": "Zebrafish", "refseq_name": "nucleoporin NDC1", "refseq_ac": "NP_956237", "gene_names_uniprotkb": "ndc1; tmem48; wu:fk93f04; zgc:55636", "gene_names_refseq": "ndc1; tmem48; wu:fk93f04; zgc:55636", "protein_names_uniprotkb": "Nucleoporin NDC1; Transmembrane protein 48", "protein_names_refseq": "nucleoporin NDC1; transmembrane protein 48", "tax_id": 7955, "disease": "", "pathway": " (dre:335236); (R-DRE-159227); (R-DRE-159231); (R-DRE-159236); (R-DRE-1855170); (R-DRE-1855196); (R-DRE-1855229); (R-DRE-191859); (R-DRE-3108214); (R-DRE-3232142); (R-DRE-3301854); (R-DRE-3371453); (R-DRE-4551638); (R-DRE-9615933)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053915.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053915.1., [RefSeq]; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0031965 nuclear membrane;GO:0005643 nuclear pore", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SZC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZYZ7-1", "uniprot_id": "PCGF1_DANRE", "mass": 30768.0, "length": 261, "protein_name": "Polycomb group RING finger protein 1", "gene_name": "pcgf1", "organism": "Zebrafish", "refseq_name": "polycomb group RING finger protein 1", "refseq_ac": "NP_001007159", "gene_names_uniprotkb": "pcgf1; nspc1; si:zc207o21.2", "gene_names_refseq": "nspc1; pcgf1; si:zc207o21.2", "protein_names_uniprotkb": "Polycomb group RING finger protein 1", "protein_names_refseq": "RING finger; nervous system polycomb 1; polycomb group RING finger protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:368900)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19024384;23594743;27442247", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134012.1, EH485491.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134012.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility., [UniProtKB, UniProtKB]; Nspc1 was expressed globally at the early stage., [RefSeq, PubMed]; Pcgf1 is involved in cell proliferation during early embryogenesis and establishes a link between epigenetics and aging. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0031519 PcG protein complex;GO:0035102 PRC1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0021915 neural tube development;GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZYZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZ56-1", "uniprot_id": "TM218_DANRE", "mass": 12563.0, "length": 115, "protein_name": "Transmembrane protein 218", "gene_name": "tmem218", "organism": "Zebrafish", "refseq_name": "transmembrane protein 218", "refseq_ac": "NP_956692", "gene_names_uniprotkb": "tmem218; zgc:63675", "gene_names_refseq": "tmem218; zgc:63675", "protein_names_uniprotkb": "Transmembrane protein 218", "protein_names_refseq": "transmembrane protein 218", "tax_id": 7955, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Joubert syndrome (Disease Ontology:DOID:0050777)", "pathway": " (dre:393369)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054131.1, EH579423.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054131.1., [RefSeq]; May be involved in ciliary biogenesis or function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:1901207 regulation of heart looping;GO:0090660 cerebrospinal fluid circulation;GO:0039021 pronephric glomerulus development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SZ56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3E6-1", "uniprot_id": "BMI1B_DANRE", "mass": 36655.0, "length": 324, "protein_name": "Polycomb complex protein BMI-1-B", "gene_name": "bmi1b", "organism": "Zebrafish", "refseq_name": "polycomb complex protein BMI-1-B", "refseq_ac": "NP_001074220", "gene_names_uniprotkb": "bmi1b; pcgf4b", "gene_names_refseq": "bmi1b; pcgf4b", "protein_names_uniprotkb": "Polycomb complex protein BMI-1-B; Polycomb group RING finger protein 4-B", "protein_names_refseq": "B lymphoma Mo-MLV insertion region 1b; bmi1 polycomb ring finger oncogene 1b; polycomb complex protein BMI-1-B; polycomb group RING finger protein 4-B; polycomb group ring finger 4 B", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal Wilms' tumor (Disease Ontology:DOID:5176); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:394249)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01015945.1, GDQQ01009227.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Mar 11, 2007 this sequence version replaced XP_001337502.1., [RefSeq]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0031519 PcG protein complex;GO:0035102 PRC1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0021549 cerebellum development;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T3E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUH1-1", "uniprot_id": "RTRAF_DANRE", "mass": 27858.0, "length": 242, "protein_name": "tRNA-splicing ligase complex subunit RTRAF", "gene_name": "rtraf", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rtraf; zgc:56576", "gene_names_refseq": "", "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit RTRAF; RNA transcription, translation and transport factor protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393240)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16412219;26469318;27189481;28252024;31723061", "class_list": "", "function": "Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Could also play a role in RNA transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZUH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T297-1", "uniprot_id": "ARB2A_DANRE", "mass": 48208.0, "length": 415, "protein_name": "Cotranscriptional regulator ARB2A homolog", "gene_name": "arb2a", "organism": "Zebrafish", "refseq_name": "cotranscriptional regulator ARB2A homolog precursor", "refseq_ac": "NP_001418035", "gene_names_uniprotkb": "arb2a; fam172a; si:dkey-172f14.1; zgc:64188", "gene_names_refseq": "arb2a; fam172a; si:dkey-172f14.1; zgc:64188", "protein_names_uniprotkb": "Cotranscriptional regulator ARB2A homolog; Cotranscriptional regulator FAM172A homolog; Protein FAM172A", "protein_names_refseq": "cotranscriptional regulator ARB2A homolog precursor; cotranscriptional regulator ARB2A homolog; cotranscriptional regulator FAM172A homolog; family with sequence similarity 172 member A; protein FAM172A", "tax_id": 7955, "disease": "", "pathway": " (dre:393390)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19478994;26469318;27189481;35079792", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1259614.1, SRR32588715.2826731.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001418035.1., [RefSeq]; May play role in the regulation of alternative splicing. May have hydrolase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0031048 regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVJ6-1", "uniprot_id": "QTRT2_DANRE", "mass": 46090.0, "length": 416, "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "qtrt2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "qtrt2; QTRT2; qtrtd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase accessory subunit 2; Queuine tRNA-ribosyltransferase domain-containing protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:402798)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZVJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVE0-1", "uniprot_id": "GAR1_DANRE", "mass": 22813.0, "length": 226, "protein_name": "H/ACA ribonucleoprotein complex subunit 1", "gene_name": "gar1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gar1; nola1; zgc:56086", "gene_names_refseq": "", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 1; Nucleolar protein family A member 1; snoRNP protein GAR1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393950); (R-DRE-171319); (R-DRE-174430)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19563808;22299032", "class_list": "", "function": "Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0060216 definitive hemopoiesis;GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZVE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZT42-1", "uniprot_id": "SND1_DANRE", "mass": 100535.0, "length": 897, "protein_name": "Staphylococcal nuclease domain-containing protein 1", "gene_name": "snd1", "organism": "Zebrafish", "refseq_name": "staphylococcal nuclease domain-containing protein 1 isoform p100S", "refseq_ac": "NP_001280610", "gene_names_uniprotkb": "snd1; SN4TDR; TDRD11; sn4tdr; wu:fc27g10", "gene_names_refseq": "SN4TDR; TDRD11; snd1; wu:fc27g10", "protein_names_uniprotkb": "Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; 4SNc-Tudor domain protein; p100 co-activator", "protein_names_refseq": "100 kDa coactivator; 4SNc-Tudor domain protein; p100 co-activator; staphylococcal nuclease domain containing 1; staphylococcal nuclease domain-containing protein 1 isoform p100S; staphylococcal nuclease domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:324404)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12598568;12753931;16132464;18339436;21745576;27189481;28252024;28590408;31059868;36495292", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF422806.1, SRR32588735.937736.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. Transcript Variant: This variant (p100S) lacks multiple 3' exons and extends beyond a splice site used in variant p100L. The resulting protein (isoform p100S) is shorter and has a distinct C-terminus compared to isoform p100L. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs., [UniProtKB, UniProtKB]; Two alternative transcripts of p100 are expressed during embryogenesis and regulated by Nodal signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DEI2;Q7SX79;Q7ZZS7;Q8AXL0", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004521 RNA endonuclease activity;GO:0003723 RNA binding;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031332 RNAi effector complex", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZT42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYM0-1", "uniprot_id": "UCK2A_DANRE", "mass": 29628.0, "length": 261, "protein_name": "Uridine-cytidine kinase 2-A", "gene_name": "uck2a", "organism": "Zebrafish", "refseq_name": "uridine-cytidine kinase 2-A", "refseq_ac": "NP_001164538", "gene_names_uniprotkb": "uck2a; si:ch211-216k22.2", "gene_names_refseq": "uck2a; umpk; wu:fk91a01; zgc:66240", "protein_names_uniprotkb": "Uridine-cytidine kinase 2-A; 2.7.1.48; Cytidine monophosphokinase 2-A; UCK 2-A; Uridine monophosphokinase 2-A", "protein_names_refseq": "UCK 2-A; cytidine monophosphokinase 2-A; uridine monophosphate kinase; uridine monophosphokinase 2-A; uridine-cytidine kinase 2-A", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:100005763); (R-DRE-73614)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588726.7628124.1, SRR32588718.41071770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Mar 12, 2010 this sequence version replaced NP_956234.1., [RefSeq]; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SYM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYN4-1", "uniprot_id": "5NT3_DANRE", "mass": 32937.0, "length": 286, "protein_name": "Cytosolic 5'-nucleotidase 3", "gene_name": "nt5c3a; nt5c3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "nt5c3a; nt5c3; fb30h07; nt5c3; wu:fb30h07; zgc:66117", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic 5'-nucleotidase 3; 3.1.3.5; Cytosolic 5'-nucleotidase III; cN-III", "protein_names_refseq": "", "tax_id": 7955, "disease": "congenital nonspherocytic hemolytic anemia 8 (Disease Ontology:DOID:0051007)", "pathway": " (dre:321720); (R-DRE-73621)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Can act both as nucleotidase and as phosphotransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.5;2.7.1.77;3.1.3.99", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SYN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZQ4-1", "uniprot_id": "MFFB_DANRE", "mass": 26253.0, "length": 230, "protein_name": "Mitochondrial fission factor homolog B", "gene_name": "mffa", "organism": "Zebrafish", "refseq_name": "mitochondrial fission factor homolog B", "refseq_ac": "NP_956830", "gene_names_uniprotkb": "mffa; mff; zgc:66022", "gene_names_refseq": "mffa; mff; zgc:66022", "protein_names_uniprotkb": "Mitochondrial fission factor homolog B", "protein_names_refseq": "mitochondrial fission factor homolog B", "tax_id": 7955, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 2 (Disease Ontology:DOID:0060994); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:393508)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056301.1, EH452608.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056301.1., [RefSeq]; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006626 protein targeting to mitochondrion;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission;GO:0090314 positive regulation of protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7SZQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZQ7-1", "uniprot_id": "SURF4_DANRE", "mass": 30191.0, "length": 269, "protein_name": "Surfeit locus protein 4", "gene_name": "surf4", "organism": "Zebrafish", "refseq_name": "surfeit locus protein 4", "refseq_ac": "NP_957421", "gene_names_uniprotkb": "surf4", "gene_names_refseq": "surf4; zgc:65806; zgc:77007", "protein_names_uniprotkb": "Surfeit locus protein 4", "protein_names_refseq": "surfeit gene 4; surfeit locus protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:394102); (R-DRE-6798695); (R-DRE-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056295.1, BC066509.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056295.1., [RefSeq]; Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0042953 lipoprotein transport;GO:0055088 lipid homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SZQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T010-1", "uniprot_id": "GATB_DANRE", "mass": 61814.0, "length": 553, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "gatb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gatb; pet112l; pet112; si:ch211-150a22.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; 6.3.5.-; Cytochrome c oxidase assembly factor PET112 homolog; Glu-AdT subunit B; PET112-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 41 (Disease Ontology:DOID:0112119)", "pathway": " (dre:541317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.5.-;6.3.5.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T047-1", "uniprot_id": "CX32_DANRE", "mass": 31885.0, "length": 277, "protein_name": "Gap junction Cx32.2 protein", "gene_name": "cx32.2", "organism": "Zebrafish", "refseq_name": "gap junction Cx32.2 protein", "refseq_ac": "NP_001025381", "gene_names_uniprotkb": "cx32.2; gjae; si:dkey-261a18.5; zgc:153825", "gene_names_refseq": "cx20e; cx31.9; cx32.2; gja13.1; gja13.2; gja13; gjae; si:dkey-261a18.5; zgc:153825", "protein_names_uniprotkb": "Gap junction Cx32.2 protein; Connexin-32.2", "protein_names_refseq": "connexin 32.2; gap junction Cx32.2 protein; gap junction protein alpha 13.1; gap junction protein, alpha e", "tax_id": 7955, "disease": "", "pathway": " (dre:566647)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15895415;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC122427.1, DY559640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122427.1. On May 28, 2009 this sequence version replaced NP_001025381.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P3V1;Q5TYN7", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T047-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T070-1", "uniprot_id": "RHBG_DANRE", "mass": 50123.0, "length": 459, "protein_name": "Ammonium transporter Rh type B", "gene_name": "rhbg", "organism": "Zebrafish", "refseq_name": "ammonium transporter Rh type B", "refseq_ac": "NP_956365", "gene_names_uniprotkb": "rhbg; si:dkey-235h8.2; zgc:56354", "gene_names_refseq": "fj85f07; rhbg; wu:fj85f07; zgc:56354", "protein_names_uniprotkb": "Ammonium transporter Rh type B; Rh family type B glycoprotein; Rh type B glycoprotein; Rhesus blood group family type B glycoprotein", "protein_names_refseq": "Rhesus blood group, B glycoprotein; ammonium transporter Rh type B; rh family type B glycoprotein; rh type B glycoprotein; rhesus blood group family type B glycoprotein", "tax_id": 7955, "disease": "", "pathway": " (dre:337596); (R-DRE-444411)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16227429;19279128;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049405.1, AF529360.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB864179.1, EH442413.1, AF529360.1, EH468298.1, EB907162.1, BC049405.1, EB769168.1, EB769155.1, DT059527.1, EB771011.1 and EB766994.1. On Oct 31, 2008 this sequence version replaced NP_956365.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity)., [UniProtKB]; Is required to facilitate normal ammonia excretion in the zebrafish larva, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWH6", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0072488 ammonium transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T141-1", "uniprot_id": "PI15A_DANRE", "mass": 29345.0, "length": 260, "protein_name": "Peptidase inhibitor 15-A", "gene_name": "pi15a", "organism": "Zebrafish", "refseq_name": "peptidase inhibitor 15-A precursor", "refseq_ac": "NP_001153449", "gene_names_uniprotkb": "pi15a; bZ1M12.1; pi15; si:rp71-1m12.1", "gene_names_refseq": "bZ1M12.1; pi15a; pi15; si:rp71-1m12.1", "protein_names_uniprotkb": "Peptidase inhibitor 15-A", "protein_names_refseq": "peptidase inhibitor 15-A precursor; peptidase inhibitor 15-A", "tax_id": 7955, "disease": "", "pathway": " (dre:561978)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH552286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476755, SAMEA4476794 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH499838.1, EH552286.1 and EH573412.1. On May 9, 2009 this sequence version replaced XP_690468.1., [RefSeq]; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T1C0-1", "uniprot_id": "FXI3B_DANRE", "mass": 41279.0, "length": 383, "protein_name": "Forkhead box protein I3-B", "gene_name": "foxi3b", "organism": "Zebrafish", "refseq_name": "forkhead box protein I3-B", "refseq_ac": "NP_944600", "gene_names_uniprotkb": "foxi3b", "gene_names_refseq": "foxi3b", "protein_names_uniprotkb": "Forkhead box protein I3-B", "protein_names_refseq": "forkhead box protein I3-B; forkhead box protein I3b", "tax_id": 7955, "disease": "Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); Goldenhar syndrome (Disease Ontology:DOID:2907)", "pathway": " (dre:387258)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14579370;17375188;17555741;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY331584.1, BC162636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY331584.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; An extensive phylogenetic analysis of the FoxI class that includes these new sequences together with those previously reported, [RefSeq, PubMed]; Transcription factor required for epithelial cell differentiation (PubMed:17375188, PubMed:17555741). Involved in specification of skin ionocytes from epidermal precursors (PubMed:17375188, PubMed:17555741)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009957 epidermal cell fate specification;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T1C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2A5-1", "uniprot_id": "EIF3L_DANRE", "mass": 67993.0, "length": 576, "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "eif3l", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit L", "refseq_ac": "NP_998293", "gene_names_uniprotkb": "eif3l; eif3eip; eif3s6ip", "gene_names_refseq": "eif3s6ip; wu:fb66c05; zgc:64147", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit L; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; eIF3l", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit L", "tax_id": 7955, "disease": "", "pathway": " (dre:406402); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054626.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054626.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T2A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2D1-1", "uniprot_id": "RD10B_DANRE", "mass": 37819.0, "length": 336, "protein_name": "Retinol dehydrogenase 10-B", "gene_name": "rdh10b", "organism": "Zebrafish", "refseq_name": "retinol dehydrogenase 10-B", "refseq_ac": "NP_958488", "gene_names_uniprotkb": "rdh10b; rdh10; si:ch211-193n21.3", "gene_names_refseq": "cb804; rdh10b; rdh10", "protein_names_uniprotkb": "Retinol dehydrogenase 10-B; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 10-B; retinol dehydrogenase 10", "tax_id": 7955, "disease": "", "pathway": " (dre:378722)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054596.1, CK030081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054596.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V2U0", "ec_number_list": "1.1.1.300", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T2D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2D4-1", "uniprot_id": "ERGI2_DANRE", "mass": 42590.0, "length": 376, "protein_name": "Endoplasmic reticulum-Golgi intermediate compartment protein 2", "gene_name": "ergic2", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum-Golgi intermediate compartment protein 2", "refseq_ac": "NP_956701", "gene_names_uniprotkb": "ergic2; zgc:64005", "gene_names_refseq": "ergic2; zgc:64005", "protein_names_uniprotkb": "Endoplasmic reticulum-Golgi intermediate compartment protein 2", "protein_names_refseq": "endoplasmic reticulum-Golgi intermediate compartment protein 2; ergic2a", "tax_id": 7955, "disease": "", "pathway": " (dre:393378)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054593.1., [RefSeq]; Possible role in transport between endoplasmic reticulum and Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T2D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2G1-1", "uniprot_id": "I2B2B_DANRE", "mass": 53711.0, "length": 501, "protein_name": "Interferon regulatory factor 2-binding protein 2-B", "gene_name": "irf2bp2b", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 2-binding protein 2-B", "refseq_ac": "NP_999917", "gene_names_uniprotkb": "irf2bp2b; irf2bp2; zgc:63864", "gene_names_refseq": "irf2bp2a; irf2bp2b; irf2bp2; wu:fa12b04; wu:fb73g01; zgc:63864", "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 2-B; IRF-2-binding protein 2-B; IRF-2BP2-B", "protein_names_refseq": "IRF-2-binding protein 2-A; IRF-2-binding protein 2-B; IRF-2BP2-A; IRF-2BP2-B; interferon regulatory factor 2 binding protein 2; interferon regulatory factor 2-binding protein 2-A; interferon regulatory factor 2-binding protein 2-B", "tax_id": 7955, "disease": "common variable immunodeficiency 14 (Disease Ontology:DOID:0081156); neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dre:406614)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31123027;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054562.1, EH439266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054562.1., [RefSeq]; Acts as a transcriptional repressor., [UniProtKB]; Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045650 negative regulation of macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T2G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T310-1", "uniprot_id": "PIGM_DANRE", "mass": 44409.0, "length": 392, "protein_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "gene_name": "pigm", "organism": "Zebrafish", "refseq_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "refseq_ac": "NP_956684", "gene_names_uniprotkb": "pigm; zgc:64177", "gene_names_refseq": "pigm; zgc:64177", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; 2.4.1.-; GPI mannosyltransferase I; GPI-MT-I; PIG-M; Phosphatidylinositol-glycan biosynthesis class M protein", "protein_names_refseq": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; PIG-M; phosphatidylinositol-glycan biosynthesis class M protein", "tax_id": 7955, "disease": "", "pathway": " (dre:393361); (R-DRE-162710)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476791, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053299.1., [RefSeq]; Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0180041 dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T312-1", "uniprot_id": "CCD25_DANRE", "mass": 24380.0, "length": 207, "protein_name": "Coiled-coil domain-containing protein 25", "gene_name": "ccdc25", "organism": "Zebrafish", "refseq_name": "coiled-coil domain-containing protein 25", "refseq_ac": "NP_956682", "gene_names_uniprotkb": "ccdc25; zgc:64173", "gene_names_refseq": "ccdc25; zgc:64173", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 25", "protein_names_refseq": "coiled-coil domain-containing protein 25", "tax_id": 7955, "disease": "", "pathway": " (dre:393359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053297.1, EH595485.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053297.1., [RefSeq]; Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:2000147 positive regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T326-1", "uniprot_id": "CISD2_DANRE", "mass": 15485.0, "length": 135, "protein_name": "CDGSH iron-sulfur domain-containing protein 2", "gene_name": "cisd2", "organism": "Zebrafish", "refseq_name": "CDGSH iron-sulfur domain-containing protein 2", "refseq_ac": "NP_956677", "gene_names_uniprotkb": "cisd2; dkey-162b23.1; zgc:64148", "gene_names_refseq": "cisd2; zgc:64148", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 2", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 2", "tax_id": 7955, "disease": "Wolfram syndrome 2 (Disease Ontology:DOID:0110630)", "pathway": " (dre:393354)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053280.1, EH548336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053280.1., [RefSeq]; Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JI01", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7T326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T330-1", "uniprot_id": "SPOP_DANRE", "mass": 42134.0, "length": 374, "protein_name": "Speckle-type POZ protein", "gene_name": "spop", "organism": "Zebrafish", "refseq_name": "speckle-type POZ protein", "refseq_ac": "NP_957424", "gene_names_uniprotkb": "spop; SPOP1; zgc:64140", "gene_names_refseq": "SPOP1; spop; zgc:64140", "protein_names_uniprotkb": "Speckle-type POZ protein; HIB homolog 1; SPOP1", "protein_names_refseq": "HIB homolog 1; speckle-type POZ protein", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:100005514); (R-DRE-5632684); (R-DRE-9929491)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16740475", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010213.1, SRR32588720.2905767.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505391 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Mar 1, 2008 this sequence version replaced XP_001344547.1., [RefSeq]; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T330-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T339-1", "uniprot_id": "CHMP5_DANRE", "mass": 24769.0, "length": 220, "protein_name": "Charged multivesicular body protein 5", "gene_name": "chmp5", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 5", "refseq_ac": "NP_956674", "gene_names_uniprotkb": "chmp5", "gene_names_refseq": "chmp5b; chmp5; zgc:64125", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Chromatin-modifying protein 5", "protein_names_refseq": "charged multivesicular body protein 5; chromatin-modifying protein 5", "tax_id": 7955, "disease": "", "pathway": " (dre:393351); (R-DRE-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053265.1, EH441605.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053265.1., [RefSeq]; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0005771 multivesicular body", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0006900 vesicle budding from membrane;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T346-1", "uniprot_id": "DDIT4_DANRE", "mass": 23976.0, "length": 220, "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "ddit4", "organism": "Zebrafish", "refseq_name": "DNA damage-inducible transcript 4 protein", "refseq_ac": "NP_956401", "gene_names_uniprotkb": "ddit4; zgc:64114", "gene_names_refseq": "ddit4; redd1; rtp801; sb:cb821; zgc:64114", "protein_names_uniprotkb": "DNA damage-inducible transcript 4 protein", "protein_names_refseq": "DNA damage-inducible transcript 4 protein; regulated in development and DNA damage response 1", "tax_id": 7955, "disease": "", "pathway": " (dre:378866); (R-DRE-5628897)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23300740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH581922.1, SRR26395063.677938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Feb 20, 2016 this sequence version replaced XP_009305270.1, XP_005173056.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Redd1 alters dorsoventral patterning by antagonizing the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0001666 response to hypoxia;GO:0006915 apoptotic process;GO:0032007 negative regulation of TOR signaling;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T346-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T381-1", "uniprot_id": "BOKB_DANRE", "mass": 23834.0, "length": 211, "protein_name": "Bcl-2-related ovarian killer protein homolog B", "gene_name": "bokb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "bokb; bok; zgc:64041", "gene_names_refseq": "", "protein_names_uniprotkb": "Bcl-2-related ovarian killer protein homolog B; zBok2", "protein_names_refseq": "", "tax_id": 7955, "disease": "hydrocephalus (Disease Ontology:DOID:10908); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:394160)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16888646", "class_list": "", "function": "May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0GKC3", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3C7-1", "uniprot_id": "RT4I1_DANRE", "mass": 42328.0, "length": 387, "protein_name": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial", "gene_name": "rtn4ip1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rtn4ip1", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD(P)H oxidoreductase RTN4IP1, mitochondrial; 1.6.5.-; Reticulon-4-interacting protein 1 homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "optic atrophy 10 (Disease Ontology:DOID:0111434)", "pathway": " (dre:393323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26593267", "class_list": "", "function": "NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3 (By similarity). Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro (By similarity). However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo (By similarity). May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.5.-", "go_molecular_function": "GO:0018455 alcohol dehydrogenase [NAD(P)+] activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010842 retina layer formation;GO:0006744 ubiquinone biosynthetic process;GO:0042462 eye photoreceptor cell development;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T3C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3D1-1", "uniprot_id": "ERO1A_DANRE", "mass": 56589.0, "length": 489, "protein_name": "ERO1-like protein alpha", "gene_name": "ero1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ero1a; ERO1-L; ero1l; zgc:63959", "gene_names_refseq": "", "protein_names_uniprotkb": "ERO1-like protein alpha; 1.8.3.2; ERO1-L-alpha; ERO1-L; Endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; Oxidoreductin-1-L-alpha", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393321); (R-DRE-3299685)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;28320616;38739706", "class_list": "", "function": "Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.4.1;1.8.3.2;1.11.1.9", "go_molecular_function": "GO:0071949 FAD binding;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T3D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3E4-1", "uniprot_id": "DBR1_DANRE", "mass": 62889.0, "length": 568, "protein_name": "Lariat debranching enzyme", "gene_name": "dbr1", "organism": "Zebrafish", "refseq_name": "lariat debranching enzyme", "refseq_ac": "NP_955947", "gene_names_uniprotkb": "dbr1; zgc:63930", "gene_names_refseq": "dbr1; wu:fc08f08; zgc:63930", "protein_names_uniprotkb": "Lariat debranching enzyme; 3.1.4.-", "protein_names_refseq": "debranching enzyme homolog 1; lariat debranching enzyme", "tax_id": 7955, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (dre:323746)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053153.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053153.1., [RefSeq]; Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008419 RNA lariat debranching enzyme activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T3E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3E8-1", "uniprot_id": "MFR1L_DANRE", "mass": 34899.0, "length": 309, "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "mtfr1l", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mtfr1l; fam54b; zgc:63922", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial fission regulator 1-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:334296)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T3E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3H2-1", "uniprot_id": "INS1B_DANRE", "mass": 49568.0, "length": 453, "protein_name": "Insulinoma-associated protein 1b", "gene_name": "insm1b", "organism": "Zebrafish", "refseq_name": "insulinoma-associated protein 1b", "refseq_ac": "NP_955952", "gene_names_uniprotkb": "insm1b", "gene_names_refseq": "INSM-1; Insm1; fc13a09; insm1b; wu:fc13a09; zINSM-1; zgc:63866", "protein_names_uniprotkb": "Insulinoma-associated protein 1b; Insulinoma-associated 1-like protein b; Zinc finger protein IA-1b", "protein_names_refseq": "insulinoma-associated 1-like protein b; insulinoma-associated protein 1b; zinc finger protein IA-1b", "tax_id": 7955, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (dre:323882)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16487754;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053119.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053119.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development, [RefSeq, PubMed]; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3S5C7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030182 neuron differentiation;GO:0060290 transdifferentiation;GO:0010564 regulation of cell cycle process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T3H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3P8-1", "uniprot_id": "FEM1C_DANRE", "mass": 68479.0, "length": 618, "protein_name": "Protein fem-1 homolog C", "gene_name": "fem1c", "organism": "Zebrafish", "refseq_name": "protein fem-1 homolog C", "refseq_ac": "NP_937788", "gene_names_uniprotkb": "fem1c", "gene_names_refseq": "fem1c", "protein_names_uniprotkb": "Protein fem-1 homolog C; FEM1-gamma; FEM1c", "protein_names_refseq": "FEM1-gamma; protein fem-1 homolog C", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-8951664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14527725", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056774.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476787, SAMEA4476795 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056774.1. On Jan 25, 2004 this sequence version replaced NP_937788.1., [RefSeq]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, leading to their ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGZ5", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T3P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3Q2-1", "uniprot_id": "CRIM1_DANRE", "mass": 112223.0, "length": 1027, "protein_name": "Cysteine-rich motor neuron 1 protein", "gene_name": "crim1", "organism": "Zebrafish", "refseq_name": "cysteine-rich motor neuron 1 protein precursor", "refseq_ac": "NP_997986", "gene_names_uniprotkb": "crim1", "gene_names_refseq": "crim1; wu:fc29f08", "protein_names_uniprotkb": "Cysteine-rich motor neuron 1 protein; CRIM-1", "protein_names_refseq": "CRIM-1; cysteine-rich motor neuron 1 protein precursor; cysteine-rich motor neuron 1 protein", "tax_id": 7955, "disease": "microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:404210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16524703", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY151045.1, BC162591.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY151045.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival., [UniProtKB]; Primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0001568 blood vessel development;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T3Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3X9-1", "uniprot_id": "NARPB_DANRE", "mass": 12267.0, "length": 111, "protein_name": "Notch-regulated ankyrin repeat-containing protein B", "gene_name": "nrarpb", "organism": "Zebrafish", "refseq_name": "notch-regulated ankyrin repeat-containing protein B", "refseq_ac": "NP_852473", "gene_names_uniprotkb": "nrarpb; Nrarp-b; zgc:101875", "gene_names_refseq": "Nrarp-b; nrarpb; zgc:101875", "protein_names_uniprotkb": "Notch-regulated ankyrin repeat-containing protein B", "protein_names_refseq": "notch-regulated ankyrin repeat-containing protein B", "tax_id": 7955, "disease": "", "pathway": " (dre:353225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12711545;16228014;19154719", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.2427193.1, SRR32588734.2692258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476802 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Results show that the Notch-regulated ankyrin repeat protein (Nrarp) acts as a molecular link between Notch- and Lef1-dependent Wnt signaling in endothelial cells to control stability of new vessel connections in mouse and zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001569 branching involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T3X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTA2-1", "uniprot_id": "Q7ZTA2_DANRE", "mass": 34082.0, "length": 304, "protein_name": "Melanocyte-stimulating hormone receptor", "gene_name": "mc2r", "organism": "Zebrafish", "refseq_name": "adrenocorticotropic hormone receptor", "refseq_ac": "NP_851302", "gene_names_uniprotkb": "mc2r", "gene_names_refseq": "mc2r", "protein_names_uniprotkb": "Melanocyte-stimulating hormone receptor; Melanocortin receptor 1", "protein_names_refseq": "adrenocorticotropic hormone receptor", "tax_id": 7955, "disease": "West syndrome (Disease Ontology:DOID:0050562); glucocorticoid deficiency 1 (Disease Ontology:DOID:0080621); toxic shock syndrome (Disease Ontology:DOID:14115)", "pathway": " (R-DRE-375276)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12851332;17082325;17603878;17707598;18077507;34499158;34699755;34931659;35343814;36290123", "class_list": "", "function": "G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein. Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis. Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby downregulating melanogenesis. Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling., [UniProtKB, UniProtKB, UniProtKB]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY161848.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010468 regulation of gene expression;GO:0030325 adrenal gland development;GO:0033555 multicellular organismal response to stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZTA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTY4-1", "uniprot_id": "RBBP7_DANRE", "mass": 47752.0, "length": 426, "protein_name": "Histone-binding protein RBBP7", "gene_name": "rbbp7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rbbp7; Caf1; rbb4l; wu:fa13g08; wu:fb50h10; wu:fc29d09; zgc:56477; zgc:85617", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-binding protein RBBP7; RBBP-7; Retinoblastoma-binding protein 7", "protein_names_refseq": "", "tax_id": 7955, "disease": "X-linked spermatogenic failure 9 (Disease Ontology:DOID:0061177); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dre:322129); (R-DRE-212300); (R-DRE-2559580); (R-DRE-3214815); (R-DRE-3214841); (R-DRE-3214847); (R-DRE-3214858); (R-DRE-6804758); (R-DRE-8943724); (R-DRE-8951664); (R-DRE-8953750); (R-DRE-9764725); (R-DRE-9909649); (R-DRE-9937850); (R-DRE-9940951)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWL5", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0016581 NuRD complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006260 DNA replication;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZTY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTY7-1", "uniprot_id": "USE1_DANRE", "mass": 29588.0, "length": 258, "protein_name": "Vesicle transport protein USE1", "gene_name": "use1", "organism": "Zebrafish", "refseq_name": "vesicle transport protein USE1", "refseq_ac": "NP_956618", "gene_names_uniprotkb": "use1; use1l; zgc:56402", "gene_names_refseq": "fj43b06; use1; wu:fj43b06; zgc:56402", "protein_names_uniprotkb": "Vesicle transport protein USE1; USE1-like protein", "protein_names_refseq": "USE1-like protein; vesicle transport protein USE1", "tax_id": 7955, "disease": "", "pathway": " (dre:393294); (R-DRE-6811434)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC052105.1, SRR26395064.1102695.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1., [RefSeq]; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZTY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUC2-1", "uniprot_id": "CAB45_DANRE", "mass": 41704.0, "length": 356, "protein_name": "45 kDa calcium-binding protein", "gene_name": "sdf4", "organism": "Zebrafish", "refseq_name": "45 kDa calcium-binding protein precursor", "refseq_ac": "NP_998252", "gene_names_uniprotkb": "sdf4; cab45; zgc:76916", "gene_names_refseq": "Cab45; SDF-4; sdf4; wu:fb66d06; wu:fd46e11; zgc:56577; zgc:76916", "protein_names_uniprotkb": "45 kDa calcium-binding protein; Cab45; SDF-4; Stromal cell-derived factor 4", "protein_names_refseq": "45 kDa calcium-binding protein precursor; 45 kDa calcium-binding protein", "tax_id": 7955, "disease": "", "pathway": " (dre:406360)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066581.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX957326.8., [RefSeq]; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen", "go_biological_process": "GO:0002040 sprouting angiogenesis;GO:0017156 calcium-ion regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUL9-1", "uniprot_id": "MGRN1_DANRE", "mass": 58146.0, "length": 529, "protein_name": "Probable E3 ubiquitin-protein ligase MGRN1", "gene_name": "mgrn1a; mgrn1", "organism": "Zebrafish", "refseq_name": "probable E3 ubiquitin-protein ligase MGRN1 isoform 1", "refseq_ac": "NP_956173", "gene_names_uniprotkb": "mgrn1a; mgrn1; mgrn1; wu:fi38c03; zgc:55978", "gene_names_refseq": "mgrn1a; mgrn1; wu:fi38c03; zgc:55978", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase MGRN1; 2.3.2.27; Mahogunin RING finger protein 1; RING-type E3 ubiquitin transferase MGRN1", "protein_names_refseq": "RING-type E3 ubiquitin transferase MGRN1; mahogunin RING finger protein 1; mahogunin, ring finger 1; probable E3 ubiquitin-protein ligase MGRN1 isoform 1; probable E3 ubiquitin-protein ligase MGRN1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048069.1, SRR26395062.739135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Jun 26, 2025 this sequence version replaced XP_073774024.1, NP_956173.2., [RefSeq]; E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase. Also acts as a negative regulator of hedgehog signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005769 early endosome", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0016567 protein ubiquitination;GO:0007224 smoothened signaling pathway;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUN8-1", "uniprot_id": "YKT6_DANRE", "mass": 22405.0, "length": 198, "protein_name": "Synaptobrevin homolog YKT6", "gene_name": "ykt6", "organism": "Zebrafish", "refseq_name": "synaptobrevin homolog YKT6", "refseq_ac": "NP_957386", "gene_names_uniprotkb": "ykt6; zgc:55536", "gene_names_refseq": "ykt6; zgc:55536", "protein_names_uniprotkb": "Synaptobrevin homolog YKT6; 2.3.1.-", "protein_names_refseq": "synaptobrevin homolog YKT6", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (dre:394067); (R-DRE-204005); (R-DRE-6807878); (R-DRE-6811438); (R-DRE-8980692); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013408)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048049.1, AY391470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC048049.1. On Jul 6, 2005 this sequence version replaced XP_698640.1., [RefSeq]; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (By similarity). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (By similarity). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (By similarity). Has a S-palmitoyl transferase activity (By similarity). Essential for the structural and functional organization of the Golgi apparatus (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;3.6.5.2;2.3.1.-", "go_molecular_function": "GO:0016740 transferase activity;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZUN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUP0-1", "uniprot_id": "AN32A_DANRE", "mass": 29091.0, "length": 254, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "anp32a", "organism": "Zebrafish", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member A", "refseq_ac": "NP_956280", "gene_names_uniprotkb": "anp32a; wu:fj36e08; zgc:55516", "gene_names_refseq": "anp32a; wu:fj36e08; zgc:55516", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "protein_names_refseq": "acidic leucine-rich nuclear phosphoprotein 32 family member A", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:335907); (R-DRE-450520)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15895553;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048047.1, EH540682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476773, SAMEA4476800 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC048047.1., [RefSeq]; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex., [UniProtKB]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZUP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUP1-1", "uniprot_id": "TET5C_DANRE", "mass": 44756.0, "length": 388, "protein_name": "Terminal nucleotidyltransferase 5C", "gene_name": "tent5c", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tent5c; fam46c; fd14g08; wu:fc56d11; wu:fd14g08; zgc:55510; zgc:66197", "gene_names_refseq": "", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5C; 2.7.7.19", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:327154)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16109975;19335895;23435258;24683187;26469318", "class_list": "", "function": "Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.19;2.7.7.52", "go_molecular_function": "GO:0003723 RNA binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZUP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUV1-1", "uniprot_id": "PKHF2_DANRE", "mass": 27442.0, "length": 247, "protein_name": "Pleckstrin homology domain-containing family F member 2", "gene_name": "plekhf2", "organism": "Zebrafish", "refseq_name": "pleckstrin homology domain-containing family F member 2", "refseq_ac": "NP_956538", "gene_names_uniprotkb": "plekhf2; zgc:56073", "gene_names_refseq": "plekhf2; zgc:56073", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 2; PH domain-containing family F member 2", "protein_names_refseq": "PH domain-containing family F member 2; pleckstrin homology domain-containing family F member 2", "tax_id": 7955, "disease": "", "pathway": " (dre:393214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047820.1, EG575958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476800, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047820.1., [RefSeq]; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUW2-1", "uniprot_id": "HYOU1_DANRE", "mass": 110320.0, "length": 980, "protein_name": "Hypoxia up-regulated protein 1", "gene_name": "hyou1", "organism": "Zebrafish", "refseq_name": "hypoxia up-regulated protein 1 precursor", "refseq_ac": "NP_997868", "gene_names_uniprotkb": "hyou1; hsph4", "gene_names_refseq": "hyou1; id:ibd5056; wu:fd14c05; zgc:56019", "protein_names_uniprotkb": "Hypoxia up-regulated protein 1", "protein_names_refseq": "hypoxia up-regulated protein 1 precursor; hypoxia up-regulated protein 1; oxygen regulated protein (150kD)", "tax_id": 7955, "disease": "immunodeficiency 59 (Disease Ontology:DOID:0111974)", "pathway": " (dre:327133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505386 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047807.1. On Jul 6, 2005 this sequence version replaced XP_702563.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQN2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006950 response to stress;GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZUW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUW6-1", "uniprot_id": "WIPI3_DANRE", "mass": 38167.0, "length": 344, "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "wdr45b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "wdr45b; WIPI-3; wdr45l; wipi3; zgc:56002", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 3; WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; WIPI-3", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-1632852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUX3-1", "uniprot_id": "WIPI4_DANRE", "mass": 39641.0, "length": 358, "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "wdr45", "organism": "Zebrafish", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 4", "refseq_ac": "NP_956525", "gene_names_uniprotkb": "wdr45; wipi4", "gene_names_refseq": "wdr45; zgc:56345; zgc:77017", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4", "tax_id": 7955, "disease": "neurodegeneration with brain iron accumulation 5 (Disease Ontology:DOID:0110739)", "pathway": " (dre:393200); (R-DRE-1632852)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;38454050", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046090.1, AY398367.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046090.1., [RefSeq]; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (By similarity). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity)., [UniProtKB, UniProtKB]; Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NY84;Q6TGY9", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZUX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUX6-1", "uniprot_id": "DOHH_DANRE", "mass": 33919.0, "length": 305, "protein_name": "Deoxyhypusine hydroxylase", "gene_name": "dohh", "organism": "Zebrafish", "refseq_name": "deoxyhypusine hydroxylase", "refseq_ac": "NP_955857", "gene_names_uniprotkb": "dohh; DOHH; fb33c04; hlrc1; wu:fb33c04; zgc:56338", "gene_names_refseq": "dohh; fb33c04; hlrc1; wu:fb33c04; zgc:56338", "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; DOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase", "protein_names_refseq": "HEAT-like (PBS lyase) repeat containing 1; deoxyhypusine hydroxylase", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (R-DRE-204626)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046086.1, EH455641.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046086.1., [RefSeq]; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.29", "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "", "go_biological_process": "GO:0008612 peptidyl-lysine modification to peptidyl-hypusine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV00-1", "uniprot_id": "OTU6B_DANRE", "mass": 33507.0, "length": 293, "protein_name": "Deubiquitinase OTUD6B", "gene_name": "otud6b", "organism": "Zebrafish", "refseq_name": "deubiquitinase OTUD6B", "refseq_ac": "NP_956519", "gene_names_uniprotkb": "otud6b; zgc:56305", "gene_names_refseq": "otud6b; zgc:56305", "protein_names_uniprotkb": "Deubiquitinase OTUD6B; 3.4.19.12", "protein_names_refseq": "OTU domain containing 6B; OTU domain-containing protein 6B; deubiquitinase OTUD6B", "tax_id": 7955, "disease": "", "pathway": " (dre:393194)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34183367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046060.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046060.1., [RefSeq]; Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes., [UniProtKB, UniProtKB]; Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZV00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV22-1", "uniprot_id": "MTAP_DANRE", "mass": 30847.0, "length": 280, "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "mtap", "organism": "Zebrafish", "refseq_name": "S-methyl-5'-thioadenosine phosphorylase", "refseq_ac": "NP_956848", "gene_names_uniprotkb": "mtap; zgc:66012", "gene_names_refseq": "mtap; zgc:66012", "protein_names_uniprotkb": "S-methyl-5'-thioadenosine phosphorylase; 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MTAP", "protein_names_refseq": "S-methyl-5'-thioadenosine phosphorylase", "tax_id": 7955, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)", "pathway": " (dre:393526); (R-DRE-1237112)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056545.1, BC046035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056545.1. On Jul 6, 2005 this sequence version replaced XP_687817.1., [RefSeq]; Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHI0", "ec_number_list": "3.5.4.4;2.4.2.1;2.4.2.28", "go_molecular_function": "GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006166 purine ribonucleoside salvage;GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZV22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV26-1", "uniprot_id": "SOSSC_DANRE", "mass": 11345.0, "length": 103, "protein_name": "SOSS complex subunit C", "gene_name": "inip", "organism": "Zebrafish", "refseq_name": "SOSS complex subunit C", "refseq_ac": "NP_956513", "gene_names_uniprotkb": "inip; ssbip1; zgc:56259", "gene_names_refseq": "SOSS-C; inip; ssbip1; zgc:56259; zgc:86662", "protein_names_uniprotkb": "SOSS complex subunit C; INTS3- and NABP-interacting protein; SOSS-C; SSB-interacting protein 1; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1", "protein_names_refseq": "INTS3- and NABP-interacting protein; SOSS complex subunit C; SSB-interacting protein 1; sensor of single-strand DNA complex subunit C; sensor of ssDNA subunit C; single-stranded DNA-binding protein-interacting protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:393188)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046030.1, CT651601.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505388, SAMEA4476742 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1., [RefSeq]; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070876 SOSS complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZV26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV60-1", "uniprot_id": "BCS1_DANRE", "mass": 47492.0, "length": 420, "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "bcs1l", "organism": "Zebrafish", "refseq_name": "mitochondrial chaperone BCS1", "refseq_ac": "NP_957476", "gene_names_uniprotkb": "bcs1l; zgc:56205", "gene_names_refseq": "bcs1l; zgc:56205", "protein_names_uniprotkb": "Mitochondrial chaperone BCS1; 3.6.1.-; BCS1-like protein", "protein_names_refseq": "BC1 (ubiquinol-cytochrome c reductase) synthesis-like; BCS1-like protein; mitochondrial chaperone BCS1", "tax_id": 7955, "disease": "Bjornstad syndrome (Disease Ontology:DOID:0050677); mitochondrial complex III deficiency nuclear type 1 (Disease Ontology:DOID:0080111); GRACILE syndrome (Disease Ontology:DOID:0111455)", "pathway": " (dre:394157)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394959.1, BC045990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394959.1. On Feb 4, 2007 this sequence version replaced NP_957476.1., [RefSeq]; Chaperone necessary for the incorporation of Rieske iron-sulfur protein uqcrfs1 into the mitochondrial respiratory chain complex III., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009653 anatomical structure morphogenesis;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZV60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV68-1", "uniprot_id": "VPS29_DANRE", "mass": 20400.0, "length": 182, "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "vps29", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 29", "refseq_ac": "NP_956331", "gene_names_uniprotkb": "vps29; zK83d9.2-001", "gene_names_refseq": "fb06g05; vps29; wu:fb06g05; zgc:56191; zgc:86638", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 29; Vesicle protein sorting 29", "protein_names_refseq": "vacuolar protein sorting 29 homolog; vacuolar protein sorting-associated protein 29; vesicle protein sorting 29", "tax_id": 7955, "disease": "", "pathway": " (dre:573437); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045981.1, EH582275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045981.1. On or before Jan 29, 2008 this sequence version replaced XP_684302.1, XP_001335558.1., [RefSeq]; Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos (By similarity). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0030904 retromer complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZV68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV79-1", "uniprot_id": "UCK2B_DANRE", "mass": 29876.0, "length": 261, "protein_name": "Uridine-cytidine kinase 2-B", "gene_name": "uck2b", "organism": "Zebrafish", "refseq_name": "uridine-cytidine kinase 2-B", "refseq_ac": "NP_956058", "gene_names_uniprotkb": "uck2b; si:ch211-284b7.4; zgc:56174", "gene_names_refseq": "uck2b; wu:fa20g04; zgc:56174", "protein_names_uniprotkb": "Uridine-cytidine kinase 2-B; 2.7.1.48; Cytidine monophosphokinase 2-B; UCK 2-B; Uridine monophosphokinase 2-B", "protein_names_refseq": "UCK 2-B; cytidine monophosphokinase 2-B; uridine monophosphokinase 2-B; uridine-cytidine kinase 2-B; uridine-cytidine kinase 2", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:327057)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045968.1, SRR26395013.430947.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, CB357915.1 and EH512314.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZV79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV80-1", "uniprot_id": "SPF30_DANRE", "mass": 26940.0, "length": 237, "protein_name": "Survival of motor neuron-related-splicing factor 30", "gene_name": "smndc1", "organism": "Zebrafish", "refseq_name": "survival of motor neuron-related-splicing factor 30", "refseq_ac": "NP_997766", "gene_names_uniprotkb": "smndc1; TDRD10; spf30; wu:fb37h07; wu:fc23a07", "gene_names_refseq": "TDRD10; smndc1; spf30; wu:fb37h07; wu:fc23a07", "protein_names_uniprotkb": "Survival of motor neuron-related-splicing factor 30; Survival motor neuron domain-containing protein 1", "protein_names_refseq": "survival motor neuron domain-containing protein 1; survival of motor neuron-related-splicing factor 30", "tax_id": 7955, "disease": "", "pathway": " (dre:572679); (R-DRE-72163); (R-DRE-9770562); (R-DRE-9943411)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067338.1, GDQH01001187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Dec 13, 2007 this sequence version replaced XP_684201.1., [RefSeq]; Involved in spliceosome assembly (By similarity)., [UniProtKB, UniProtKB]; Involved in spliceosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZV80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV82-1", "uniprot_id": "RL27_DANRE", "mass": 15782.0, "length": 136, "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "rpl27", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein eL27", "refseq_ac": "NP_956018", "gene_names_uniprotkb": "rpl27; zgc:56171", "gene_names_refseq": "fc93a08; rpl27; wu:fc93a08; zgc:56171", "protein_names_uniprotkb": "Large ribosomal subunit protein eL27; 60S ribosomal protein L27", "protein_names_refseq": "60S ribosomal protein L27; large ribosomal subunit protein eL27", "tax_id": 7955, "disease": "Diamond-Blackfan anemia 16 (Disease Ontology:DOID:0111893)", "pathway": " (dre:325618); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045965.1, EE313020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045965.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the large ribosomal subunit., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022625 cytosolic large ribosomal subunit;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZV82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVA0-1", "uniprot_id": "SMU1_DANRE", "mass": 57531.0, "length": 513, "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "smu1", "organism": "Zebrafish", "refseq_name": "WD40 repeat-containing protein SMU1", "refseq_ac": "NP_956493", "gene_names_uniprotkb": "smu1; zgc:56147", "gene_names_refseq": "smu1a; smu1; zgc:56147", "protein_names_uniprotkb": "WD40 repeat-containing protein SMU1; Smu-1 suppressor of mec-8 and unc-52 protein homolog", "protein_names_refseq": "WD40 repeat-containing protein SMU1; smu-1 suppressor of mec-8 and unc-52 homolog a; smu-1 suppressor of mec-8 and unc-52 protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:393168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045945.1., [RefSeq]; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071011 precatalytic spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVB1-1", "uniprot_id": "CHM1B_DANRE", "mass": 22063.0, "length": 199, "protein_name": "Charged multivesicular body protein 1b", "gene_name": "chmp1b", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 1b", "refseq_ac": "NP_956308", "gene_names_uniprotkb": "chmp1b; Chmp1.5; fb10c03; wu:fb10c03; zgc:56134", "gene_names_refseq": "Chmp1.5; chmp1b; fb10c03; wu:fb10c03; zgc:56134", "protein_names_uniprotkb": "Charged multivesicular body protein 1b; CHMP1b; Chromatin-modifying protein 1b", "protein_names_refseq": "charged multivesicular body protein 1b; chromatin modifying protein 1B", "tax_id": 7955, "disease": "", "pathway": " (dre:336426)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045934.1., [RefSeq]; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZVB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVB2-1", "uniprot_id": "A9A1A_DANRE", "mass": 55262.0, "length": 508, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase A", "gene_name": "aldh9a1a", "organism": "Zebrafish", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase A", "refseq_ac": "NP_958879", "gene_names_uniprotkb": "aldh9a1a; aldh9a1l", "gene_names_refseq": "TMABA-DH; TMABADH; aldh9a1a.1; aldh9a1a; aldh9a1l; wu:fb64d09", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase A; 1.2.1.3; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1-A; TMABA-DH; TMABADH", "protein_names_refseq": "4-trimethylaminobutyraldehyde dehydrogenase A; aldehyde dehydrogenase 9 family, member A1 like 1; aldehyde dehydrogenase 9 family, member A1a.1; aldehyde dehydrogenase 9A1a; aldehyde dehydrogenase family 9 member A1-A", "tax_id": 7955, "disease": "", "pathway": " (dre:100005587); (R-DRE-71262)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045932.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045932.1. On or before Sep 7, 2007 this sequence version replaced XP_001339729.1, XP_001339783.1, XP_001339851.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYB3", "ec_number_list": "1.2.1.3;1.2.1.31;1.2.1.8;1.2.1.94;1.2.1.47", "go_molecular_function": "GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVK4-1", "uniprot_id": "VPS36_DANRE", "mass": 43281.0, "length": 382, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "vps36", "organism": "Zebrafish", "refseq_name": "vacuolar protein-sorting-associated protein 36", "refseq_ac": "NP_956271", "gene_names_uniprotkb": "vps36; fj33d07; wu:fj33d07; zgc:55965", "gene_names_refseq": "fj33d07; vps36; wu:fj33d07; zgc:55965", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36", "protein_names_refseq": "ESCRT-II complex subunit VPS36; vacuolar protein-sorting-associated protein 36", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (R-DRE-917729)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045509.1., [RefSeq]; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005768 endosome;GO:0031902 late endosome membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVN7-1", "uniprot_id": "MED15_DANRE", "mass": 89863.0, "length": 809, "protein_name": "Mediator of RNA polymerase II transcription subunit 15", "gene_name": "med15", "organism": "Zebrafish", "refseq_name": "mediator of RNA polymerase II transcription subunit 15", "refseq_ac": "NP_998238", "gene_names_uniprotkb": "med15; MED15; arc105; fi85b10; pcqap; wu:fd19g01; wu:fi19d01; wu:fi85b10; zgc:55839", "gene_names_refseq": "arc105; fi85b10; med15; pcqap; wu:fd19g01; wu:fi19d01; wu:fi85b10; zgc:55839", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 15; Mediator complex subunit 15", "protein_names_refseq": "PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein; activator-recruited cofactor 105 kDa component; mediator of RNA polymerase II transcription subunit 15", "tax_id": 7955, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:406346)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17208216", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045472.1, GFIL01026159.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC045472.1, JBMGRA010000021.1, CV488078.1, CK030290.1 and CV490828.1. On Nov 21, 2009 this sequence version replaced NP_998238.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVP8-1", "uniprot_id": "TM38B_DANRE", "mass": 32029.0, "length": 289, "protein_name": "Trimeric intracellular cation channel type B", "gene_name": "tmem38b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tmem38b; zgc:55815", "gene_names_refseq": "", "protein_names_uniprotkb": "Trimeric intracellular cation channel type B; TRIC-B; TRICB; Transmembrane protein 38B", "protein_names_refseq": "", "tax_id": 7955, "disease": "osteogenesis imperfecta type 14 (Disease Ontology:DOID:0110343)", "pathway": " (dre:393145)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Activated by increased cytosolic Ca(2+) levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903010 regulation of bone development;GO:0030500 regulation of bone mineralization;GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0071805 potassium ion transmembrane transport;GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVR1-1", "uniprot_id": "WDR75_DANRE", "mass": 93936.0, "length": 832, "protein_name": "WD repeat-containing protein 75", "gene_name": "wdr75", "organism": "Zebrafish", "refseq_name": "WD repeat-containing protein 75", "refseq_ac": "NP_956384", "gene_names_uniprotkb": "wdr75; SI:dZ46I22.2; cb990; flj12519; si:by113d7.2; si:by134g18.1; si:by68f21.1; si:dz46i22.2; si:dz73o4.1; si:xx-113d7.2; wu:fb53f09; wu:fb96h05; zgc:55748", "gene_names_refseq": "SI:dZ46I22.2; cb990; flj12519; si:by113d7.2; si:by134g18.1; si:by68f21.1; si:dz73o4.1; si:xx-113d7.2; wdr75; wu:fb53f09; wu:fb96h05; zgc:55748", "protein_names_uniprotkb": "WD repeat-containing protein 75", "protein_names_refseq": "WD repeat-containing protein 75", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autism spectrum disorder (Disease Ontology:DOID:0060041); subcortical band heterotopia (Disease Ontology:DOID:0111169)", "pathway": " (dre:368478)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045446.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045446.1., [RefSeq]; Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZZ52;Q8AUI8;Q8AW19;Q8JFV9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVS8-1", "uniprot_id": "CMTR2_DANRE", "mass": 83655.0, "length": 743, "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2", "gene_name": "cmtr2", "organism": "Zebrafish", "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2", "refseq_ac": "NP_998598", "gene_names_uniprotkb": "cmtr2; MTr2; ftsjd1; wu:fj48c05; zgc:55686", "gene_names_refseq": "MTr2; cmtr2; ftsjd1; wu:fj48c05; zgc:55686", "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; 2.1.1.296; Cap methyltransferase 2; Cap2 2'O-ribose methyltransferase 2; FtsJ methyltransferase domain-containing protein 1; MTr2", "protein_names_refseq": "FtsJ methyltransferase domain containing 1; FtsJ methyltransferase domain-containing protein 1; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; cap2 2'O-ribose methyltransferase 2", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045425.1, BF158539.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045425.1., [RefSeq]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.296", "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0120550 methyltransferase cap2 activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVU1-1", "uniprot_id": "GARE1_DANRE", "mass": 95793.0, "length": 867, "protein_name": "GRB2-associated and regulator of MAPK protein 1", "gene_name": "garem1", "organism": "Zebrafish", "refseq_name": "GRB2-associated and regulator of MAPK protein 1", "refseq_ac": "NP_956463", "gene_names_uniprotkb": "garem1; fam59a; garem; zgc:55634", "gene_names_refseq": "fam59a; garem1; garem; zgc:55634", "protein_names_uniprotkb": "GRB2-associated and regulator of MAPK protein 1; GRB2-associated and regulator of MAPK1", "protein_names_refseq": "GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK protein 1; GRB2-associated and regulator of MAPK1; family with sequence similarity 59, member A; protein FAM59A", "tax_id": 7955, "disease": "", "pathway": " (dre:393138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045411.1., [RefSeq]; Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070064 proline-rich region binding", "go_cellular_component": "", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0051781 positive regulation of cell division;GO:0071364 cellular response to epidermal growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVW9-1", "uniprot_id": "ARGLB_DANRE", "mass": 32556.0, "length": 269, "protein_name": "Arginine and glutamate-rich protein 1-B", "gene_name": "arglu1b", "organism": "Zebrafish", "refseq_name": "arginine and glutamate-rich protein 1-B", "refseq_ac": "NP_956456", "gene_names_uniprotkb": "arglu1b; zgc:55548", "gene_names_refseq": "arglu1b; zgc:55548", "protein_names_uniprotkb": "Arginine and glutamate-rich protein 1-B", "protein_names_refseq": "arginine and glutamate-rich protein 1-B", "tax_id": 7955, "disease": "", "pathway": " (dre:393131)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30698747;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045379.1, EL651906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476747 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045379.1. On Jul 6, 2005 this sequence version replaced XP_702233.1., [RefSeq]; Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZVW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVX0-1", "uniprot_id": "CCNL1_DANRE", "mass": 57405.0, "length": 498, "protein_name": "Cyclin-L1", "gene_name": "ccnl1", "organism": "Zebrafish", "refseq_name": "cyclin-L1", "refseq_ac": "NP_956034", "gene_names_uniprotkb": "ccnl1; zgc:55544", "gene_names_refseq": "ccnl1b; ccnl1; fd99b09; wu:fd99b09; zgc:55544", "protein_names_uniprotkb": "Cyclin-L1", "protein_names_refseq": "cyclin L ania-6a; cyclin-L1", "tax_id": 7955, "disease": "", "pathway": " (dre:326088)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045378.1, BC165619.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045378.1., [RefSeq]; Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVX5-1", "uniprot_id": "REEP3_DANRE", "mass": 29222.0, "length": 256, "protein_name": "Receptor expression-enhancing protein 3", "gene_name": "reep3", "organism": "Zebrafish", "refseq_name": "receptor expression-enhancing protein 3", "refseq_ac": "NP_956455", "gene_names_uniprotkb": "reep3; zgc:55529", "gene_names_refseq": "im:6909180; reep3b; reep3; sb:eu299; zgc:55529", "protein_names_uniprotkb": "Receptor expression-enhancing protein 3", "protein_names_refseq": "receptor accessory protein 3; receptor expression-enhancing protein 3", "tax_id": 7955, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (dre:393130)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045373.1, EH549032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045373.1. On Jul 6, 2005 this sequence version replaced XP_702232.1., [RefSeq]; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0051301 cell division;GO:0007084 mitotic nuclear membrane reassembly;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVX6-1", "uniprot_id": "UBA3_DANRE", "mass": 51663.0, "length": 462, "protein_name": "NEDD8-activating enzyme E1 catalytic subunit", "gene_name": "uba3", "organism": "Zebrafish", "refseq_name": "NEDD8-activating enzyme E1 catalytic subunit", "refseq_ac": "NP_998632", "gene_names_uniprotkb": "uba3; ube1c; wu:fb75e04; wu:fc37b11; zgc:55528", "gene_names_refseq": "uba3; ube1c; wu:fb75e04; wu:fc37b11; zgc:55528", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 catalytic subunit; 6.2.1.64; NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3", "protein_names_refseq": "NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)", "tax_id": 7955, "disease": "", "pathway": " (dre:406776); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045372.1, BC165593.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045372.1., [RefSeq]; Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.34;6.2.1.45;2.3.2.23;2.3.2.25;6.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVY5-1", "uniprot_id": "CISY_DANRE", "mass": 51751.0, "length": 468, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "cs", "organism": "Zebrafish", "refseq_name": "citrate synthase, mitochondrial precursor", "refseq_ac": "NP_955892", "gene_names_uniprotkb": "cs; zgc:55507", "gene_names_refseq": "cs; wu:fb58e04; zgc:55507", "protein_names_uniprotkb": "Citrate synthase, mitochondrial; 2.3.3.1; Citrate (Si)-synthase", "protein_names_refseq": "citrate (Si)-synthase; citrate synthase, mitochondrial precursor; citrate synthase, mitochondrial", "tax_id": 7955, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:322339); (R-DRE-71403); (R-DRE-9837999); (R-DRE-9854311)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045362.1, BC165743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045362.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.4.21.53;1.2.4.1;1.2.4.2;2.7.11.-;3.6.4.10;1.3.8.1;1.3.8.5;2.1.1.-;2.3.1.9;4.2.1.2;2.3.3.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0036440 citrate synthase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0005975 carbohydrate metabolic process;GO:0014823 response to activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVZ6-1", "uniprot_id": "PREP_DANRE", "mass": 114972.0, "length": 1023, "protein_name": "Presequence protease, mitochondrial", "gene_name": "pitrm1", "organism": "Zebrafish", "refseq_name": "presequence protease, mitochondrial precursor", "refseq_ac": "NP_998652", "gene_names_uniprotkb": "pitrm1; zgc:55469", "gene_names_refseq": "pitrm1; wu:fa03d09; zgc:55469", "protein_names_uniprotkb": "Presequence protease, mitochondrial; 3.4.24.-; Pitrilysin metalloproteinase 1", "protein_names_refseq": "pitrilysin metalloproteinase 1; presequence protease, mitochondrial precursor; presequence protease, mitochondrial", "tax_id": 7955, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 30 (Disease Ontology:DOID:0070411); Alzheimer's disease (Disease Ontology:DOID:10652); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (dre:406808); (R-DRE-1268020)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045351.1, BC165169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045351.1., [RefSeq]; Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.3.3;1.1.98.-;3.4.24.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVZ7-1", "uniprot_id": "AB17C_DANRE", "mass": 32663.0, "length": 294, "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "abhd17c", "organism": "Zebrafish", "refseq_name": "alpha/beta hydrolase domain-containing protein 17C", "refseq_ac": "NP_956451", "gene_names_uniprotkb": "abhd17c; zgc:55468", "gene_names_refseq": "abhd17c; fam108c1; zgc:55468", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17C; 3.1.2.22; Abhydrolase domain-containing protein 17C", "protein_names_refseq": "abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; alpha/beta hydrolase domain-containing protein 17C; family with sequence similarity 108, member C1; protein ABHD17C", "tax_id": 7955, "disease": "", "pathway": " (dre:393126); (R-DRE-9648002)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045350.1, CK687910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045350.1. On Jul 6, 2005 this sequence version replaced XP_702230.1., [RefSeq]; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards nras., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.1.2.22;3.4.19.12;3.1.1.93;3.1.2.2", "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane;GO:0010008 endosome membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:0099175 regulation of postsynapse organization;GO:1902817 negative regulation of protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW16-1", "uniprot_id": "RNF41_DANRE", "mass": 36128.0, "length": 318, "protein_name": "E3 ubiquitin-protein ligase NRDP1", "gene_name": "rnf41", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase NRDP1", "refseq_ac": "NP_998681", "gene_names_uniprotkb": "rnf41; nrdp1; zgc:55389", "gene_names_refseq": "rnf41; wu:fi13f07; wu:fi25b06; zgc:55389", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NRDP1; 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1", "protein_names_refseq": "E3 ubiquitin-protein ligase NRDP1; RING-type E3 ubiquitin transferase NRDP1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:406837); (R-DRE-1358803); (R-DRE-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21596016", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045329.1, EL649225.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505385, SAMEA3505386 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045329.1., [RefSeq]; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins., [UniProtKB, UniProtKB]; Nrdp1 is associated with differentiation process of the melanocyte lineage by regulating Erbb3b, an Erbb signaling molecule along zebrafish embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0097191 extrinsic apoptotic signaling pathway;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030318 melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZW16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW25-1", "uniprot_id": "CHM2A_DANRE", "mass": 25108.0, "length": 220, "protein_name": "Charged multivesicular body protein 2a", "gene_name": "chmp2a", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 2a", "refseq_ac": "NP_998682", "gene_names_uniprotkb": "chmp2a; bc2", "gene_names_refseq": "bc2; chmp2a; fj10d05; wu:fi18h03; wu:fj10d05; zgc:55361", "protein_names_uniprotkb": "Charged multivesicular body protein 2a; CHMP2a; Chromatin-modifying protein 2a", "protein_names_refseq": "charged multivesicular body protein 2a; chromatin modifying protein 2A; chromatin-modifying protein 2a; putative breast adenocarcinoma marker", "tax_id": 7955, "disease": "", "pathway": " (dre:798901); (R-DRE-1632852); (R-DRE-917729); (R-DRE-9668328)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045320.1, BC171414.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045320.1. On Jan 9, 2008 this sequence version replaced XP_001335455.1., [RefSeq]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0031902 late endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0010458 exit from mitosis;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZW25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW34-1", "uniprot_id": "CNTN5_DANRE", "mass": 116202.0, "length": 1056, "protein_name": "Contactin-5", "gene_name": "cntn5", "organism": "Zebrafish", "refseq_name": "contactin-5", "refseq_ac": "NP_956098", "gene_names_uniprotkb": "cntn5; fi09g01; wu:fi09g01; zgc:55318", "gene_names_refseq": "cntn5; fi09g01; wu:fi09g01; zgc:55318", "protein_names_uniprotkb": "Contactin-5", "protein_names_refseq": "contactin-5", "tax_id": 7955, "disease": "", "pathway": " (dre:327429)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045307.1, CU458951.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045307.1., [RefSeq]; Contactins mediate cell surface interactions during nervous system development., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZW34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW41-1", "uniprot_id": "RPB7_DANRE", "mass": 19248.0, "length": 172, "protein_name": "DNA-directed RNA polymerase II subunit RPB7", "gene_name": "polr2g", "organism": "Zebrafish", "refseq_name": "DNA-directed RNA polymerase II subunit RPB7", "refseq_ac": "NP_955963", "gene_names_uniprotkb": "polr2g; polr2gl; wu:fc18d05; zgc:55297", "gene_names_refseq": "polr2gl; polr2g; wu:fc18d05; zgc:55297", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7", "protein_names_refseq": "DNA-directed RNA polymerase II subunit RPB7; RNA polymerase II subunit B7; polymerase (RNA) II (DNA directed) polypeptide G-like", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:324088); (R-DRE-113418); (R-DRE-674695); (R-DRE-6781823); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-6796648); (R-DRE-6803529); (R-DRE-6807505); (R-DRE-72086); (R-DRE-72163); (R-DRE-72165); (R-DRE-72203); (R-DRE-73776); (R-DRE-73779); (R-DRE-75953); (R-DRE-75955); (R-DRE-76042); (R-DRE-77075); (R-DRE-9018519); (R-DRE-9770562)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045299.1, EH549311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045299.1., [RefSeq]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RPB4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)., [UniProtKB]; DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003727 single-stranded RNA binding;GO:0003697 single-stranded DNA binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0005665 RNA polymerase II, core complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZW41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW63-1", "uniprot_id": "NUF2_DANRE", "mass": 53632.0, "length": 454, "protein_name": "Kinetochore protein Nuf2", "gene_name": "nuf2", "organism": "Zebrafish", "refseq_name": "kinetochore protein Nuf2", "refseq_ac": "NP_956604", "gene_names_uniprotkb": "nuf2; cdca1; zgc:56708", "gene_names_refseq": "nuf2; zgc:56708", "protein_names_uniprotkb": "Kinetochore protein Nuf2; Cell division cycle-associated protein 1", "protein_names_refseq": "NDC80 kinetochore complex component NUF2; NUF2, NDC80 kinetochore complex component, homolog; cell division cycle-associated protein 1; kinetochore protein Nuf2; un-named hi2769; unm hi2769", "tax_id": 7955, "disease": "oral cavity carcinoma in situ (Disease Ontology:DOID:0050610); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:393280); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050181.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050181.1., [RefSeq]; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007507 heart development;GO:0051301 cell division;GO:0045132 meiotic chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZW63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW77-1", "uniprot_id": "MSMO1_DANRE", "mass": 34807.0, "length": 291, "protein_name": "Methylsterol monooxygenase 1", "gene_name": "msmo1", "organism": "Zebrafish", "refseq_name": "methylsterol monooxygenase 1", "refseq_ac": "NP_998518", "gene_names_uniprotkb": "msmo1; sc4mol; zgc:56437", "gene_names_refseq": "koliber; msmo1; sc4mol; wu:fb59g06; wu:fb66e06; zgc:56437", "protein_names_uniprotkb": "Methylsterol monooxygenase 1; 1.14.18.9; C-4 methylsterol oxidase", "protein_names_refseq": "C-4 methylsterol oxidase; methylsterol monooxygenase 1", "tax_id": 7955, "disease": "chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (dre:406662); (R-DRE-6807047)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050163.1, EH450782.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050163.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.18.9", "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0032330 regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZW77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW78-1", "uniprot_id": "RN181_DANRE", "mass": 18033.0, "length": 156, "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "rnf181", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF181", "refseq_ac": "NP_956600", "gene_names_uniprotkb": "rnf181; si:ch211-102c2.10; zgc:56424", "gene_names_refseq": "rnf181; zgc:56424", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF181; 2.3.2.27; RING finger protein 181", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF181; RING-type E3 ubiquitin transferase RNF181", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-8866654)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050161.1, EH444418.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050161.1., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V3A5;B0V3A6", "ec_number_list": "2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZW78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWC4-1", "uniprot_id": "PELO_DANRE", "mass": 43081.0, "length": 385, "protein_name": "Protein pelota homolog", "gene_name": "pelo", "organism": "Zebrafish", "refseq_name": "protein pelota homolog", "refseq_ac": "NP_957430", "gene_names_uniprotkb": "pelo", "gene_names_refseq": "ITGA1; pelo; wu:fa12c12; wu:fb97f07; zgc:56550", "protein_names_uniprotkb": "Protein pelota homolog", "protein_names_refseq": "pelota homolog; protein pelota homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:394111); (R-DRE-9954714)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049484.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049484.1., [RefSeq]; Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0071025 RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWF4-1", "uniprot_id": "RN145_DANRE", "mass": 77649.0, "length": 685, "protein_name": "RING finger protein 145", "gene_name": "rnf145", "organism": "Zebrafish", "refseq_name": "RING finger protein 145", "refseq_ac": "NP_956057", "gene_names_uniprotkb": "rnf145; zgc:56435", "gene_names_refseq": "fa20f10; rnf145b; rnf145; wu:fa20f10; zgc:56435", "protein_names_uniprotkb": "RING finger protein 145", "protein_names_refseq": "RING finger protein 145", "tax_id": 7955, "disease": "", "pathway": " (dre:327056)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049437.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049437.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030097 hemopoiesis;GO:0036503 ERAD pathway;GO:0061515 myeloid cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZZ25-1", "uniprot_id": "ATD1A_DANRE", "mass": 42580.0, "length": 380, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "atad1a", "organism": "Zebrafish", "refseq_name": "outer mitochondrial transmembrane helix translocase", "refseq_ac": "NP_001004640", "gene_names_uniprotkb": "atad1a; ATPase; si:zc156n3.1; zgc:101570", "gene_names_refseq": "ATPase; atad1a; si:zc156n3.1; zgc:101570", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; ATPase family AAA domain-containing protein 1-A", "protein_names_refseq": "ATPase family AAA domain-containing protein 1-A; outer mitochondrial transmembrane helix translocase", "tax_id": 7955, "disease": "hyperekplexia 4 (Disease Ontology:DOID:0080581)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081379.1, GDQH01026913.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66IE9", "ec_number_list": "7.4.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0009653 anatomical structure morphogenesis;GO:0140570 extraction of mislocalized protein from mitochondrial outer membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZZ25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZZ76-1", "uniprot_id": "Q7ZZ76_DANRE", "mass": 49192.0, "length": 438, "protein_name": "Flotillin", "gene_name": "flot1a", "organism": "Zebrafish", "refseq_name": "flotillin-1a", "refseq_ac": "NP_570988", "gene_names_uniprotkb": "flot1a; flot1; reggie2; si:dz44o19.1; wu:fj45g11", "gene_names_refseq": "flot1a; flot1; reggie2; si:dz44o19.1; wu:fj45g11", "protein_names_uniprotkb": "Flotillin", "protein_names_refseq": "flotillin 1; flotillin-1a; reggie-2a", "tax_id": 7955, "disease": "", "pathway": " (dre:561345); (R-DRE-8849932); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10799891;11120825;11220619;11821916;15690489;27903883;28225561;28252024;36835354;38809858", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX927188.11. On May 17, 2009 this sequence version replaced XP_689844.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed that re-1a mRNA is present at high levels in expression domains that overlap with the combined expression pattern of both re-2 genes except at the somites., [RefSeq, PubMed]; These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y8S9;A0A8N7XJ54;Q1LUU9", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016600 flotillin complex;GO:0016020 membrane", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0072659 protein localization to plasma membrane;GO:0002090 regulation of receptor internalization;GO:0045807 positive regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZZ76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZZB1-1", "uniprot_id": "Q7ZZB1_DANRE", "mass": 63681.0, "length": 562, "protein_name": "Sorting nexin", "gene_name": "snx9a", "organism": "Zebrafish", "refseq_name": "sorting nexin-9a", "refseq_ac": "NP_001012313", "gene_names_uniprotkb": "snx9a; si:bz36d5.4; snx9; zgc:113455", "gene_names_refseq": "si:bz36d5.4; snx9a; snx9; zgc:113455", "protein_names_uniprotkb": "Sorting nexin", "protein_names_refseq": "sorting nexin 9; sorting nexin-9a", "tax_id": 7955, "disease": "", "pathway": " (dre:368424)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22213104;23072875;26469318;27189481;27519738;38270285", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505377 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000017.1. On Oct 5, 2007 this sequence version replaced NP_001012313.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N494", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0000281 mitotic cytokinesis;GO:0036089 cleavage furrow formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZZB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q800E7-1", "uniprot_id": "Q800E7_DANRE", "mass": 99531.0, "length": 858, "protein_name": "Phosphodiesterase", "gene_name": "pde6a", "organism": "Zebrafish", "refseq_name": "rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "refseq_ac": "NP_001007161", "gene_names_uniprotkb": "pde6a; si:bz1d10.3; si:rp71-1d10.3", "gene_names_refseq": "pde6a; si:bz1d10.3; si:rp71-1d10.3", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "cGMP-specific; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "tax_id": 7955, "disease": "retinitis pigmentosa 43 (Disease Ontology:DOID:0110379); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:368410); (R-DRE-2485179); (R-DRE-2514859); (R-DRE-4086398)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16379021;18824093;21261954;24413151;24924194;34095146;35563172;37263342;37351277;37683759", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029809.1, BC076534.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Dec 14, 2011 this sequence version replaced XP_003199938.1. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; PDE6alpha' activity is important for the survival of cones in zebrafish, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N2Q4", "ec_number_list": "3.1.4.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q800E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q800G8-1", "uniprot_id": "MXB_DANRE", "mass": 71287.0, "length": 627, "protein_name": "Interferon-induced GTP-binding protein MxB", "gene_name": "mxb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mxb", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein MxB; IFN-inducible antiviral protein MxB; Interferon-inducible MxB protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); liver disease (Disease Ontology:DOID:409); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); alopecia areata (Disease Ontology:DOID:986)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12869211", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0051607 defense response to virus;GO:0009615 response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q800G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802F2-1", "uniprot_id": "SELTA_DANRE", "mass": 22261.0, "length": 193, "protein_name": "Thioredoxin reductase-like selenoprotein T1a", "gene_name": "selenot1a", "organism": "Zebrafish", "refseq_name": "thioredoxin reductase-like selenoprotein T1a precursor", "refseq_ac": "NP_840075", "gene_names_uniprotkb": "selenot1a; selt1a; sept1a", "gene_names_refseq": "cb700; selenot1a; selt1a; sept1a; wu:fb63h09; wu:fc79a12", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T1a; 1.8.1.9", "protein_names_refseq": "thioredoxin reductase-like enzyme; thioredoxin reductase-like selenoprotein T1a precursor; thioredoxin reductase-like selenoprotein T1a", "tax_id": 7955, "disease": "", "pathway": " (dre:352919)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12915322", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054578.1, EH550504.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB359649.1, EH438162.1, BC054578.1 and EH473273.1. On Sep 14, 2007 this sequence version replaced NP_840075.1. This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Paralogs of this gene are found on chromosomes 18 (GeneID:352921) and 14 (GeneID:352917). [provided by RefSeq, Aug 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0Z8S3", "ec_number_list": "1.8.1.9", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q802F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802U2-1", "uniprot_id": "MIOS_DANRE", "mass": 98182.0, "length": 876, "protein_name": "GATOR2 complex protein MIOS", "gene_name": "mios", "organism": "Zebrafish", "refseq_name": "GATOR2 complex protein MIOS", "refseq_ac": "NP_958490", "gene_names_uniprotkb": "mios; zgc:55958", "gene_names_refseq": "mios; zgc:55958", "protein_names_uniprotkb": "GATOR2 complex protein MIOS", "protein_names_refseq": "GATOR complex protein MIOS; GATOR2 complex protein MIOS; WD repeat-containing protein mio", "tax_id": 7955, "disease": "", "pathway": " (dre:393208); (R-DRE-9639288)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38898112", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047198.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047198.1. On Jul 6, 2005 this sequence version replaced XP_702496.1., [RefSeq]; As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex., [UniProtKB, UniProtKB]; Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0060047 heart contraction;GO:0031669 cellular response to nutrient levels;GO:0060841 venous blood vessel development;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q802U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802W2-1", "uniprot_id": "A9A1B_DANRE", "mass": 56438.0, "length": 518, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase B", "gene_name": "aldh9a1b", "organism": "Zebrafish", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase B", "refseq_ac": "NP_958916", "gene_names_uniprotkb": "aldh9a1b; TMABA-DH; TMABADH; aldh9a1; si:ch211-284b7.5", "gene_names_refseq": "TMABA-DH; TMABADH; aldh9a1b; aldh9a1", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase B; 1.2.1.3; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1-B; TMABA-DH; TMABADH", "protein_names_refseq": "4-trimethylaminobutyraldehyde dehydrogenase B; aldehyde dehydrogenase 9 family, member A1; aldehyde dehydrogenase 9A1b; aldehyde dehydrogenase family 9 member A1-B", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047176.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AWD6", "ec_number_list": "1.2.1.3;1.2.1.31;1.2.1.8;1.2.1.94;1.2.1.47", "go_molecular_function": "GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q802W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803A0-1", "uniprot_id": "JADE1_DANRE", "mass": 94548.0, "length": 829, "protein_name": "Protein Jade-1", "gene_name": "jade1", "organism": "Zebrafish", "refseq_name": "protein Jade-1", "refseq_ac": "NP_956099", "gene_names_uniprotkb": "jade1; fi11a04; phf17; wu:fi11a04; zgc:55323", "gene_names_refseq": "fi11a04; jade1; phf17; wu:fi11a04; zgc:55323", "protein_names_uniprotkb": "Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17", "protein_names_refseq": "PHD finger protein 17; jade family PHD finger protein 1; protein Jade-1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-3214847)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14612400;22654112", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046874.1, BN000276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046874.1., [RefSeq]; Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation., [UniProtKB, UniProtKB]; The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q803A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803A8-1", "uniprot_id": "WWOX_DANRE", "mass": 46322.0, "length": 412, "protein_name": "WW domain-containing oxidoreductase", "gene_name": "wwox", "organism": "Zebrafish", "refseq_name": "WW domain-containing oxidoreductase", "refseq_ac": "NP_957207", "gene_names_uniprotkb": "wwox; zgc:55975", "gene_names_refseq": "wwox; zgc:55975", "protein_names_uniprotkb": "WW domain-containing oxidoreductase; 1.1.1.-", "protein_names_refseq": "WW domain-containing oxidoreductase", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 12 (Disease Ontology:DOID:0080060); developmental and epileptic encephalopathy 28 (Disease Ontology:DOID:0080452); Leber congenital amaurosis (Disease Ontology:DOID:14791); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:393887); (R-DRE-1251985); (R-DRE-8866904); (R-DRE-8866907)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044560.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044560.1. On Jul 6, 2005 this sequence version replaced XP_702396.1., [RefSeq]; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803C7-1", "uniprot_id": "LMBRL_DANRE", "mass": 55147.0, "length": 491, "protein_name": "Limb region 1 homolog-like protein", "gene_name": "lmbr1l", "organism": "Zebrafish", "refseq_name": "limb region 1 homolog-like protein", "refseq_ac": "NP_942575", "gene_names_uniprotkb": "lmbr1l; zgc:55912", "gene_names_refseq": "Limr; cb582; lmbr1l; mp:zf637-2-001648; sb:cb19; sb:cb582; sb:cb756; zgc:55912", "protein_names_uniprotkb": "Limb region 1 homolog-like protein", "protein_names_refseq": "limb region 1 homolog-like protein; limb region 1 like; limb region 1-like protein; zf637-2-001648", "tax_id": 7955, "disease": "bone development disease (Disease Ontology:DOID:0080006)", "pathway": " (dre:321314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044535.1., [RefSeq]; May play a role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). May act as a LCN1 receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006898 receptor-mediated endocytosis;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803C9-1", "uniprot_id": "PTSS1_DANRE", "mass": 54418.0, "length": 465, "protein_name": "Phosphatidylserine synthase 1", "gene_name": "ptdss1", "organism": "Zebrafish", "refseq_name": "phosphatidylserine synthase 1", "refseq_ac": "NP_957250", "gene_names_uniprotkb": "ptdss1; si:ch211-269k10; zgc:55906", "gene_names_refseq": "PSS-1; ptdss1a; ptdss1; zgc:55906", "protein_names_uniprotkb": "Phosphatidylserine synthase 1; 2.7.8.29; PSS-1; PtdSer synthase 1; Serine-exchange enzyme I", "protein_names_refseq": "phosphatidylserine synthase 1; ptdSer synthase 1; serine-exchange enzyme I", "tax_id": 7955, "disease": "Lenz-Majewski hyperostotic dwarfism (Disease Ontology:DOID:0111507)", "pathway": " (dre:393931); (R-DRE-1483101)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044533.1., [RefSeq]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QQF3", "ec_number_list": "2.7.8.29", "go_molecular_function": "GO:0106258 L-serine-phosphatidylcholine phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803E1-1", "uniprot_id": "NCBP3_DANRE", "mass": 78338.0, "length": 694, "protein_name": "Nuclear cap-binding protein subunit 3", "gene_name": "ncbp3", "organism": "Zebrafish", "refseq_name": "nuclear cap-binding protein subunit 3", "refseq_ac": "NP_956437", "gene_names_uniprotkb": "ncbp3; zgc:55870", "gene_names_refseq": "ncbp3; zgc:55870", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 3", "protein_names_refseq": "nuclear cap-binding protein subunit 3", "tax_id": 7955, "disease": "", "pathway": " (dre:393112)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044520.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044520.1., [RefSeq]; Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q803E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803G5-1", "uniprot_id": "SAM5A_DANRE", "mass": 52089.0, "length": 469, "protein_name": "Sorting and assembly machinery component 50 homolog A", "gene_name": "samm50a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "samm50a; samm50; zgc:55803", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting and assembly machinery component 50 homolog A", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (dre:393111); (R-DRE-9013404)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the maintenance of the structure of mitochondrial cristae., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0001889 liver development;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803H4-1", "uniprot_id": "CENPA_DANRE", "mass": 16681.0, "length": 145, "protein_name": "Histone H3-like centromeric protein A", "gene_name": "cenpa", "organism": "Zebrafish", "refseq_name": "histone H3-like centromeric protein A", "refseq_ac": "NP_001157712", "gene_names_uniprotkb": "cenpa", "gene_names_refseq": "CENP-A; cenpa", "protein_names_uniprotkb": "Histone H3-like centromeric protein A; CENP-A; Centromere protein A", "protein_names_refseq": "centromere protein A; histone H3-like centromeric protein A", "tax_id": 7955, "disease": "", "pathway": " (dre:100302659)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC044483.1, SRR26395012.210424.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1., [RefSeq]; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803I2-1", "uniprot_id": "ERGI3_DANRE", "mass": 43139.0, "length": 383, "protein_name": "Endoplasmic reticulum-Golgi intermediate compartment protein 3", "gene_name": "ergic3", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 1", "refseq_ac": "NP_001028277", "gene_names_uniprotkb": "ergic3; zgc:113959; zgc:55762", "gene_names_refseq": "ergic3; sdbcag84; zgc:113959; zgc:55762", "protein_names_uniprotkb": "Endoplasmic reticulum-Golgi intermediate compartment protein 3", "protein_names_refseq": "endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 1; endoplasmic reticulum-Golgi intermediate compartment protein 3; serologically defined breast cancer antigen 84", "tax_id": 7955, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (dre:393990)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC100125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100125.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1)., [RefSeq]; Possible role in transport between endoplasmic reticulum and Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498P7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q803I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803J8-1", "uniprot_id": "ZC3HF_DANRE", "mass": 49214.0, "length": 433, "protein_name": "Zinc finger CCCH domain-containing protein 15", "gene_name": "zc3h15", "organism": "Zebrafish", "refseq_name": "zinc finger CCCH domain-containing protein 15", "refseq_ac": "NP_956182", "gene_names_uniprotkb": "zc3h15; dfrp1; lerepo4; wu:fi40a12; zgc:55674", "gene_names_refseq": "lerepo4; wu:fi40a12; zc3h15; zgc:55674", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 15", "protein_names_refseq": "zinc finger CCCH domain-containing protein 15", "tax_id": 7955, "disease": "", "pathway": " (dre:334307); (R-DRE-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044451.1, BC165333.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044451.1. On Jul 6, 2005 this sequence version replaced XP_702160.1., [RefSeq]; Protects drg1 from proteolytic degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803P1-1", "uniprot_id": "EI3JB_DANRE", "mass": 29887.0, "length": 263, "protein_name": "Eukaryotic translation initiation factor 3 subunit J-B", "gene_name": "eif3jb", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit J-B", "refseq_ac": "NP_998667", "gene_names_uniprotkb": "eif3jb; eif3s1b; zgc:55443", "gene_names_refseq": "eif3jb; wu:fi35e11; zgc:55443", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit J-B; Eukaryotic translation initiation factor 3 subunit 1-B; eIF-3-alpha-B; eIF3 p35-B; eIF3j-B", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit J-B", "tax_id": 7955, "disease": "", "pathway": " (dre:406823)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044399.1, EH507161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044399.1. On Jul 6, 2005 this sequence version replaced XP_683506.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803Q2-1", "uniprot_id": "NDL1B_DANRE", "mass": 38443.0, "length": 344, "protein_name": "Nuclear distribution protein nudE-like 1-B", "gene_name": "ndel1b", "organism": "Zebrafish", "refseq_name": "nuclear distribution protein nudE-like 1-B", "refseq_ac": "NP_958464", "gene_names_uniprotkb": "ndel1b", "gene_names_refseq": "ndel1b; wu:fi23c04; wu:fi23e06", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1-B", "protein_names_refseq": "NudE-like protein 1b; nuclear distribution protein nudE-like 1-B; nudE nuclear distribution gene E homolog like 1 B", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:333957); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "17482883", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044386.2, GDQQ01015037.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1., [RefSeq]; Ndel1b is expressed predominantly in the somites in developing zebrafish., [RefSeq, PubMed]; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0007020 microtubule nucleation;GO:0010975 regulation of neuron projection development;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803R5-1", "uniprot_id": "CMTR1_DANRE", "mass": 94900.0, "length": 829, "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "gene_name": "cmtr1", "organism": "Zebrafish", "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "refseq_ac": "NP_956427", "gene_names_uniprotkb": "cmtr1; MTr1; ftsjd2; zgc:55336", "gene_names_refseq": "MTr1; cmtr1; ftsjd2; zgc:55336", "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; 2.1.1.57; Cap methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; FtsJ methyltransferase domain-containing protein 2; MTr1", "protein_names_refseq": "FtsJ methyltransferase domain containing 2; S-adenosyl-L-methionine-dependent methyltransferase ftsjd2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; cap1 2'O-ribose methyltransferase 1; ftsJ methyltransferase domain-containing protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:393102)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044371.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044371.1., [RefSeq]; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)., [UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.57", "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping;GO:0016556 mRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803U7-1", "uniprot_id": "EXO1_DANRE", "mass": 88594.0, "length": 806, "protein_name": "Exonuclease 1", "gene_name": "exo1", "organism": "Zebrafish", "refseq_name": "exonuclease 1", "refseq_ac": "NP_998634", "gene_names_uniprotkb": "exo1; fc16e04; wu:fc16e04; zgc:55521", "gene_names_refseq": "exo1; fc16e04; wu:fc16e04; zgc:55521", "protein_names_uniprotkb": "Exonuclease 1; 3.1.-.-; Exonuclease I", "protein_names_refseq": "exonuclease 1; exonuclease I", "tax_id": 7955, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (R-DRE-5358565)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044187.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044187.1., [RefSeq]; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006310 DNA recombination;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A096X8J7-1", "uniprot_id": "B3A3_DANRE", "mass": 132420.0, "length": 1170, "protein_name": "Anion exchange protein 3", "gene_name": "Slc4a3; slc4a3", "organism": "Zebrafish", "refseq_name": "anion exchange protein 3 isoform 2", "refseq_ac": "NP_001289693", "gene_names_uniprotkb": "Slc4a3; slc4a3; AE 3; Ae3", "gene_names_refseq": "AE 3; Ae3; slc4a3", "protein_names_uniprotkb": "Anion exchange protein 3; AE 3; Solute carrier family 4 member 3", "protein_names_refseq": "anion exchange protein 3 isoform 2; anion exchange protein 3; solute carrier family 4 (anion exchanger), member 3; solute carrier family 4 anion exchanger member 3", "tax_id": 7955, "disease": "short QT syndrome (Disease Ontology:DOID:0050793); anemia (Disease Ontology:DOID:2355)", "pathway": " (dre:100333073); (R-DRE-425381)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23594743;24668450;27189481;29167417;36806574", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KF771000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jul 27, 2023 this sequence version replaced NP_001289693.1., [RefSeq]; Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome., [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (By similarity). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We conclude that multiple repeat elements have disrupted the 5'-end of the zebrafish ae3 gene, associated with N-terminal truncation of the protein and reduced anion transport activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:0086001 cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A096X8J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0B4J1A5-1", "uniprot_id": "A0A0B4J1A5_DANRE", "mass": 64933.0, "length": 626, "protein_name": "EWS RNA-binding protein 1a", "gene_name": "ewsr1a", "organism": "Zebrafish", "refseq_name": "EWS RNA-binding protein 1a", "refseq_ac": "NP_001108610", "gene_names_uniprotkb": "ewsr1a; EWSR1; fc04c01; wu:fc04c01", "gene_names_refseq": "EWSR1; ewsr1a; fc04c01; wu:fc04c01", "protein_names_uniprotkb": "EWS RNA-binding protein 1a", "protein_names_refseq": "EWS RNA-binding protein 1a; Ewing sarcoma breakpoint region 1a; Ewing sarcoma breakpoint region 1", "tax_id": 7955, "disease": "Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (dre:323597)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17912356;19417137;25617839;26100283;27189481;27898262;30165106;30631305;35929537;37867960", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056281.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN835703.1, BC068397.1, FP154885.1, DT075886.1, FP131351.1 and EH467947.1. On Mar 7, 2008 this sequence version replaced XP_685548.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development Publication Status: Online-Only, [RefSeq, PubMed]; Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation., [RefSeq, PubMed]; Mutation of the EWS gene modulates Sox9 gene expression essential for chondrocyte differentiation. Erratum:[PLoS One. 2015 Mar 30;10(3):e0123487. doi: 10.1371/journal.pone.0123487. PMID: 25822618] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1TRE3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006355 regulation of DNA-templated transcription;GO:0007088 regulation of mitotic nuclear division;GO:0021954 central nervous system neuron development;GO:0051256 mitotic spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0B4J1A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KRU2-1", "uniprot_id": "A0A0G2KRU2_DANRE", "mass": 60073.0, "length": 530, "protein_name": "Lipoprotein lipase", "gene_name": "LOC101884800", "organism": "Zebrafish", "refseq_name": "lipoprotein lipase", "refseq_ac": "XP_005174466", "gene_names_uniprotkb": "LOC101884800", "gene_names_refseq": "LOC101884800", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.34", "protein_names_refseq": "lipoprotein lipase", "tax_id": 7955, "disease": "", "pathway": " (dre:101884800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BLP2", "ec_number_list": "3.1.1.34;3.1.1.-;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.3;3.1.1.5;3.1.1.116;3.1.1.6", "go_molecular_function": "GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0019433 triglyceride catabolic process;GO:0034372 very-low-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KRU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHB8-1", "uniprot_id": "A0A8M1RHB8_DANRE", "mass": 92707.0, "length": 818, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ntrk3b", "organism": "Zebrafish", "refseq_name": "NT-3 growth factor receptor isoform X2", "refseq_ac": "XP_002662799", "gene_names_uniprotkb": "ntrk3b", "gene_names_refseq": "ntrk3b", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "NT-3 growth factor receptor isoform X2", "tax_id": 7955, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); stomach cancer (Disease Ontology:DOID:10534); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); borna disease (Disease Ontology:DOID:5154); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:798577)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002662799.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043121 neurotrophin binding;GO:0005030 neurotrophin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RHB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IAH0-1", "uniprot_id": "A0A0R4IAH0_DANRE", "mass": 116426.0, "length": 1052, "protein_name": "Histone deacetylase", "gene_name": "hdac4", "organism": "Zebrafish", "refseq_name": "histone deacetylase 4 isoform X1", "refseq_ac": "XP_005172586", "gene_names_uniprotkb": "hdac4; wu:fa96d08; wu:fc56f08; zgc:152701", "gene_names_refseq": "hdac4; wu:fa96d08; wu:fc56f08; zgc:152701", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "histone deacetylase 4 isoform X1", "tax_id": 7955, "disease": "ataxia telangiectasia (Disease Ontology:DOID:12704); impotence (Disease Ontology:DOID:1875); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-4090294); (R-DRE-4551638); (R-DRE-8951936)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJV4", "ec_number_list": "3.5.1.98;3.4.13.9;3.5.1.-;2.3.2.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001755 neural crest cell migration;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IAH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IB13-1", "uniprot_id": "A0A0R4IB13_DANRE", "mass": 81884.0, "length": 727, "protein_name": "DNA repair protein Ku80", "gene_name": "xrcc5", "organism": "Zebrafish", "refseq_name": "X-ray repair cross-complementing protein 5", "refseq_ac": "NP_001017360", "gene_names_uniprotkb": "xrcc5; Ku80; im:7137560; si:ch211-239d11.4", "gene_names_refseq": "Ku80; im:7137560; si:ch211-239d11.4; xrcc5", "protein_names_uniprotkb": "DNA repair protein Ku80; 4.2.99.18; 5.6.2.4", "protein_names_refseq": "DNA binding protein; X-ray repair cross-complementing protein 5", "tax_id": 7955, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); rectum cancer (Disease Ontology:DOID:1993); basal cell carcinoma (Disease Ontology:DOID:2513); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dre:449848); (R-DRE-5693571); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15914672;17638406;18764902;19328561;20047468;30955321;31043511;31462198;33598573;34798058", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY877316.1, GDQH01005405.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR339053.18 and CR392344.9. On Jun 13, 2015 this sequence version replaced NP_001017360.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in non-homologous end joining (NHEJ) DNA double strand break repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N4T7", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;2.7.1.11;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;2.7.1.40;1.1.1.205;5.6.2.-;5.4.2.11;5.4.2.4;2.7.1.35;1.13.11.34;2.7.11.1;2.7.7.7;2.7.7.49;3.2.2.-;5.6.2.5;3.6.5.-;3.1.-.-;3.1.4.-;4.2.99.-;3.6.1.-;4.1.2.13;2.7.11.24;1.11.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0042162 telomeric DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0043564 Ku70:Ku80 complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0043066 negative regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IB13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IB28-1", "uniprot_id": "A0A0R4IB28_DANRE", "mass": 69455.0, "length": 619, "protein_name": "Hypoxia inducible factor 1 subunit alpha, like isoform X1", "gene_name": "hif1al", "organism": "Zebrafish", "refseq_name": "hypoxia inducible factor 1 subunit alpha, like isoform X1", "refseq_ac": "XP_005157629", "gene_names_uniprotkb": "hif1al; Hif-3alpha; zgc:63965", "gene_names_refseq": "Hif-3alpha; hif1al; zgc:63965", "protein_names_uniprotkb": "Hypoxia inducible factor 1 subunit alpha, like isoform X1", "protein_names_refseq": "hypoxia inducible factor 1 subunit alpha, like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005157629.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3Q6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051402 neuron apoptotic process;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription;GO:0014823 response to activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IB28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IB93-1", "uniprot_id": "UBP48_DANRE", "mass": 120405.0, "length": 1047, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 48", "gene_name": "usp48", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "usp48; im:7139343; zgc:112364", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 48; 3.4.19.12; Ubiquitin specific peptidase 48", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 85 (Disease Ontology:DOID:0070605)", "pathway": " (dre:100332674); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20040115;23594743;26469318;27189481;28450118;30446521;34059922", "class_list": "", "function": "Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BK68", "ec_number_list": "3.4.19.12;2.3.2.27", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0010996 response to auditory stimulus;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IB93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IBA4-1", "uniprot_id": "A0A0R4IBA4_DANRE", "mass": 46622.0, "length": 419, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "kyat3.1", "organism": "Zebrafish", "refseq_name": "kynurenine--oxoglutarate transaminase 3", "refseq_ac": "XP_699860", "gene_names_uniprotkb": "kyat3.1", "gene_names_refseq": "kyat3.1", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "kynurenine--oxoglutarate transaminase 3", "tax_id": 7955, "disease": "", "pathway": " (dre:571201)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_699860.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TFT2", "ec_number_list": "4.4.1.13;2.6.1.63;2.6.1.7;2.6.1.39;2.6.1.4;2.6.1.73;2.6.1.1", "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IBA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IBL7-1", "uniprot_id": "HTF4_DANRE", "mass": 77512.0, "length": 726, "protein_name": "Transcription factor 12", "gene_name": "tcf12", "organism": "Zebrafish", "refseq_name": "transcription factor 12", "refseq_ac": "NP_999981", "gene_names_uniprotkb": "tcf12; SO:0001217; TCF-12; wu:fb74g05; wu:fc43e06; zgc:110341; zgc:85956", "gene_names_refseq": "TCF-12; tcf12; wu:fb74g05; wu:fc43e06; zgc:110341; zgc:85956", "protein_names_uniprotkb": "Transcription factor 12; TCF-12", "protein_names_refseq": "TF12; transcription factor 12", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); craniosynostosis 3 (Disease Ontology:DOID:0061011); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:407985); (R-DRE-8939236)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;32620954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC070024.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070024.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci., [RefSeq, PubMed]; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PFS7;E9QDA6;Q6NSM7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031175 neuron projection development;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IBL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ID09-1", "uniprot_id": "A0A0R4ID09_DANRE", "mass": 82670.0, "length": 733, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6ka3a", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-1 isoform X1", "refseq_ac": "XP_005165175", "gene_names_uniprotkb": "rps6ka3a; id:ibd1103; rps6ka3; si:ch211-114c12.12; wu:fk86e02; zgc:56006", "gene_names_refseq": "id:ibd1103; rps6ka3a; rps6ka3; si:ch211-114c12.12; wu:fk86e02; zgc:56006", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-1 isoform X1", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 19 (Disease Ontology:DOID:0112019); intellectual disability (Disease Ontology:DOID:1059); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (R-DRE-198753); (R-DRE-199920); (R-DRE-2559582); (R-DRE-442742); (R-DRE-444257); (R-DRE-881907)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCC5", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043588 skin development;GO:0038202 TORC1 signaling;GO:0048565 digestive tract development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4ID09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ID68-1", "uniprot_id": "A0A0R4ID68_DANRE", "mass": 85020.0, "length": 779, "protein_name": "ATP-dependent 6-phosphofructokinase", "gene_name": "pfklb", "organism": "Zebrafish", "refseq_name": "phosphofructokinase, liver b", "refseq_ac": "NP_001315318", "gene_names_uniprotkb": "pfklb; zgc:110298", "gene_names_refseq": "pfklb; zgc:110298", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase; 2.7.1.11; ATP-PFK; Phosphofructokinase; Phosphohexokinase", "protein_names_refseq": "phosphofructokinase, liver b", "tax_id": 7955, "disease": "", "pathway": " (dre:550259); (R-DRE-6798695); (R-DRE-70171)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "23341543;27292639;28005350;28102299;28217809;34278746;35685883;36408747;36535130;39069827", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01024352.1, SRR32588715.755871.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 16, 2016 this sequence version replaced XP_009304613.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3T0", "ec_number_list": "4.2.99.18;5.6.2.4;2.7.1.11;3.6.4.13;2.7.1.40;1.1.1.205;5.4.2.11;5.4.2.4;2.7.1.35;1.13.11.34;3.2.1.31;3.6.5.-;2.3.2.27;3.6.4.6;4.1.2.13;2.7.11.24;1.11.1.6", "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4ID68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IDP3-1", "uniprot_id": "ZH15A_DANRE", "mass": 37352.0, "length": 328, "protein_name": "Palmitoyltransferase ZDHHC15A", "gene_name": "zdhhc15a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "zdhhc15a; zgc:103780", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC15A; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC15A; Zinc finger DHHC domain-containing protein 15A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). May thereby regulate target proteins association and localization to membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0072657 protein localization to membrane;GO:0016188 synaptic vesicle maturation;GO:0140450 protein targeting to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0R4IDP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAL6-1", "uniprot_id": "A0A8M2BAL6_DANRE", "mass": 161200.0, "length": 1419, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "tnika", "organism": "Zebrafish", "refseq_name": "TRAF2 and NCK interacting kinase a isoform X1", "refseq_ac": "XP_005163444", "gene_names_uniprotkb": "tnika; fc52d11; msn; tnikl; wu:fc52d11; zgc:63535", "gene_names_refseq": "fc52d11; msn; tnika; tnikl; wu:fc52d11; zgc:63535", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "TRAF2 and NCK interacting kinase a isoform X1", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 54 (Disease Ontology:DOID:0081216); epilepsy (Disease Ontology:DOID:1826)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008360 regulation of cell shape;GO:0007369 gastrulation;GO:0060027 convergent extension involved in gastrulation;GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IF65-1", "uniprot_id": "A0A0R4IF65_DANRE", "mass": 100048.0, "length": 889, "protein_name": "DNA replication licensing factor MCM2", "gene_name": "mcm2", "organism": "Zebrafish", "refseq_name": "DNA replication licensing factor MCM2", "refseq_ac": "NP_775364", "gene_names_uniprotkb": "mcm2; cb737; chunp6905", "gene_names_refseq": "cb737; chunp6905; mcm2", "protein_names_uniprotkb": "DNA replication licensing factor MCM2; 3.6.4.12; DNA replication licensing factor mcm2", "protein_names_refseq": "DNA replication licensing factor MCM2; MCM2 minichromosome maintenance deficient 2, mitotin", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 70 (Disease Ontology:DOID:0110592); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:192338); (R-DRE-68867); (R-DRE-68949); (R-DRE-68962); (R-DRE-69052)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "15716491;16373575;16714409;18974873;23213226;32367800;33763998;34162866;36495292;36644807", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006067.1, BC066422.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1 and EH588242.1. On Jun 25, 2015 this sequence version replaced NP_775364.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PE13", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;2.7.11.1;2.7.7.7;5.6.2.-;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome;GO:0042555 MCM complex", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0048538 thymus development;GO:1902017 regulation of cilium assembly;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IF65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z266-1", "uniprot_id": "A0A8M6Z266_DANRE", "mass": 301900.0, "length": 2635, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "itpr3", "organism": "Zebrafish", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1", "refseq_ac": "XP_017212869", "gene_names_uniprotkb": "itpr3; si:dkey-163f12.8", "gene_names_refseq": "itpr3; si:dkey-163f12.8", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); immunodeficiency 133 (Disease Ontology:DOID:0061096); pre-eclampsia (Disease Ontology:DOID:10591); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:794666)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17331947;19320994;19500364;21172006;23376035;28024160;28252024;28835471;29931586;30784759", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0001501 skeletal system development;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6Z266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IH79-1", "uniprot_id": "A0A0R4IH79_DANRE", "mass": 107788.0, "length": 966, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "lonp1", "organism": "Zebrafish", "refseq_name": "lon protease homolog, mitochondrial", "refseq_ac": "XP_691712", "gene_names_uniprotkb": "lonp1; LONP1", "gene_names_refseq": "lonp1", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53", "protein_names_refseq": "lon protease homolog, mitochondrial", "tax_id": 7955, "disease": "CODAS syndrome (Disease Ontology:DOID:0111274)", "pathway": " (dre:563257); (R-DRE-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_691712.3. COMPLETENESS: full length., [RefSeq]; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T7A0", "ec_number_list": "5.6.2.3;3.4.21.53;1.2.4.2;2.7.11.-;1.3.8.1;1.3.8.5;1.1.98.-;2.3.1.9;4.2.1.2;2.3.3.1", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043565 sequence-specific DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0007005 mitochondrion organization;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0009653 anatomical structure morphogenesis;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IH79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IHF0-1", "uniprot_id": "A0A0R4IHF0_DANRE", "mass": 56216.0, "length": 491, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 2 isoform X1", "gene_name": "pacsin2", "organism": "Zebrafish", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 2 isoform X1", "refseq_ac": "XP_005168648", "gene_names_uniprotkb": "pacsin2; zgc:77519", "gene_names_refseq": "pacsin2; zgc:77519", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 2 isoform X1", "protein_names_refseq": "protein kinase C and casein kinase substrate in neurons protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:404601)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16466575;19997509;26469318;27189481;30683896;35150283;35616009", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BFX2", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0097320 plasma membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IHF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PKT2-1", "uniprot_id": "A0A8M9PKT2_DANRE", "mass": 223046.0, "length": 2056, "protein_name": "Agrin", "gene_name": "agrn", "organism": "Zebrafish", "refseq_name": "agrin isoform X1", "refseq_ac": "XP_021325504", "gene_names_uniprotkb": "agrn; hm:gc12; sb:eu553; wu:fb57e07", "gene_names_refseq": "agrn; hm:gc12; sb:eu553; wu:fb57e07", "protein_names_uniprotkb": "Agrin", "protein_names_refseq": "agrin isoform X1", "tax_id": 7955, "disease": "congenital myasthenic syndrome 8 (Disease Ontology:DOID:0110657)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Depending on alternative splicing and post-translational modifications, it has a role in different processes, including neuromuscular junction formation and maintenance, and regulation of neurite outgrowth. Also involved in positive regulation of cartilage formation through alpha-dystroglycan binding and up-regulation of SOX9., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043236 laminin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005604 basement membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0050808 synapse organization;GO:0061024 membrane organization;GO:0007417 central nervous system development;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PKT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IJZ0-1", "uniprot_id": "A0A0R4IJZ0_DANRE", "mass": 110346.0, "length": 970, "protein_name": "protein kinase C", "gene_name": "pkn2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase N2-like", "refseq_ac": "XP_700704", "gene_names_uniprotkb": "pkn2a", "gene_names_refseq": "pkn2a", "protein_names_uniprotkb": "protein kinase C; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase N2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:571965); (R-DRE-5625740); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_700704.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T8C2", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;3.1.4.4;1.14.14.18;3.6.5.2", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0035556 intracellular signal transduction;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IJZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ILB2-1", "uniprot_id": "FLC2A_DANRE", "mass": 51800.0, "length": 470, "protein_name": "Choline/ethanolamine transporter flvcr2a", "gene_name": "flvcr2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "flvcr2a; Mfsd7c-a", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline/ethanolamine transporter flvcr2a; Feline leukemia virus subgroup C receptor-related protein 2 homolog A; Heme transporter flvcr2a; Major facilitator superfamily domain containing 7C-a", "protein_names_refseq": "", "tax_id": 7955, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (dre:565210)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;38302740", "class_list": "", "function": "Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (By similarity). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (By similarity). Also acts as a heme b transporter (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TF83", "ec_number_list": "", "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097037 heme export;GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4ILB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IM31-1", "uniprot_id": "ORA1_DANRE", "mass": 34498.0, "length": 316, "protein_name": "Olfactory receptor class A-like protein 1", "gene_name": "ora1", "organism": "Zebrafish", "refseq_name": "olfactory receptor class A-like protein 1", "refseq_ac": "NP_001124140", "gene_names_uniprotkb": "ora1; Vlr2", "gene_names_refseq": "ora1; vir2; vn1r1l; zgc:194316", "protein_names_uniprotkb": "Olfactory receptor class A-like protein 1; Vomeronasal type-1 receptor-like protein", "protein_names_refseq": "V1R2; V1r pheromone receptor-like; V1r-like homolog; olfactory receptor class A-like protein 1; vn1r2l; vomeronasal 1 receptor 1 like; vomeronasal type-1 receptor-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:553133)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15809442;17717047;23594743;24831010", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163621.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC163621.1. On Mar 30, 2011 this sequence version replaced NP_001018340.1., [RefSeq]; 4-hydroxyphenylacetic acid might function as a pheromone for reproductive behavior in zebrafish. ORA1 is ancestral to mammalian V1Rs, [RefSeq, PubMed]; Probable pheromone receptor. Shows high specificity for 4-hydroxyphenylacetic acid. Activation of the receptor stimulates intracellular calcium release., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A8E0W7;B3DJV6;Q58QC6;Q597G5", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity;GO:0072545 L-tyrosine binding;GO:0033293 monocarboxylic acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0019236 response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0R4IM31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IN14-1", "uniprot_id": "A0A0R4IN14_DANRE", "mass": 72355.0, "length": 643, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "raf1a", "organism": "Zebrafish", "refseq_name": "Raf-1 proto-oncogene, serine/threonine kinase a", "refseq_ac": "NP_571514", "gene_names_uniprotkb": "raf1a; c-raf; craf; raf1", "gene_names_refseq": "c-raf; craf; raf1a; raf1", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; Raf-1", "protein_names_refseq": "Raf-1 proto-oncogene, serine/threonine kinase a; serine/threonine protein kinase RAF1; v-raf-1 murine leukemia viral oncogene homolog 1a; v-raf-1 murine leukemia viral oncogene homolog 1", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); prostate cancer (Disease Ontology:DOID:10283); prostate adenocarcinoma (Disease Ontology:DOID:2526); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (dre:30716); (R-DRE-392517); (R-DRE-430116); (R-DRE-5621575); (R-DRE-5673000); (R-DRE-5674135); (R-DRE-5674499); (R-DRE-5675221); (R-DRE-9732724)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "10207156;12925535;16109975;17397257;17603482;28791256;31263281;33279959;36229514;38152479", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB098700.1, GFIL01032163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476745, SAMEA4476762 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 26, 2015 this sequence version replaced NP_571514.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P820", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;3.1.3.16;3.6.5.2;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;3.6.4.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0000165 MAPK cascade;GO:0043408 regulation of MAPK cascade;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IN14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8L6-1", "uniprot_id": "A0A8M2B8L6_DANRE", "mass": 257103.0, "length": 2350, "protein_name": "histone acetyltransferase", "gene_name": "crebbpa", "organism": "Zebrafish", "refseq_name": "CREB-binding protein isoform X1", "refseq_ac": "XP_005161826", "gene_names_uniprotkb": "crebbpa", "gene_names_refseq": "crebbpa", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "CREB-binding protein isoform X1", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-eclampsia (Disease Ontology:DOID:10591); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:566841)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0140297 DNA-binding transcription factor binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PIL7-1", "uniprot_id": "HMCS1_DANRE", "mass": 57840.0, "length": 526, "protein_name": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic", "gene_name": "hmgcs1", "organism": "Zebrafish", "refseq_name": "hydroxymethylglutaryl-CoA synthase, cytoplasmic", "refseq_ac": "NP_957379", "gene_names_uniprotkb": "hmgcs1; zgc:56481", "gene_names_refseq": "hmgcs1; zgc:56481", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); hydroxymethylglutaryl-CoA synthase, cytoplasmic", "tax_id": 7955, "disease": "HMG-CoA synthase 2 deficiency (Disease Ontology:DOID:0081168); extrahepatic cholestasis (Disease Ontology:DOID:13619); hepatocellular carcinoma (Disease Ontology:DOID:684); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:394060)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;39531736", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049456.1, GFIL01012659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On or before Jun 16, 2016 this sequence version replaced XP_005155547.1, NP_957379.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis., [UniProtKB, UniProtKB]; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.3.10", "go_molecular_function": "GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0006084 acetyl-CoA metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0014033 neural crest cell differentiation;GO:0014003 oligodendrocyte development;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1PIL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IQJ3-1", "uniprot_id": "A0A0R4IQJ3_DANRE", "mass": 444001.0, "length": 4003, "protein_name": "Extracellular matrix organizing protein FRAS1 isoform X1", "gene_name": "fras1", "organism": "Zebrafish", "refseq_name": "extracellular matrix organizing protein FRAS1 isoform X1", "refseq_ac": "XP_005165392", "gene_names_uniprotkb": "fras1; id:ibd5080; pif; si:ch211-191a6.5; wu:fc10b09", "gene_names_refseq": "fras1; id:ibd5080; pif; si:ch211-191a6.5; wu:fc10b09", "protein_names_uniprotkb": "Extracellular matrix organizing protein FRAS1 isoform X1", "protein_names_refseq": "extracellular matrix organizing protein FRAS1 isoform X1", "tax_id": 7955, "disease": "Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 1 (Disease Ontology:DOID:0111405); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (dre:563428)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11731487;18816440;20419147;21552255;32112658;33543035;35679135;37870737;39496611;9007245", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BCL6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007154 cell communication;GO:0007492 endoderm development;GO:0010669 epithelial structure maintenance;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IQJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IQY2-1", "uniprot_id": "A0A0R4IQY2_DANRE", "mass": 51408.0, "length": 455, "protein_name": "Kynureninase", "gene_name": "kynu", "organism": "Zebrafish", "refseq_name": "kynureninase", "refseq_ac": "XP_009300357", "gene_names_uniprotkb": "kynu; KYNU", "gene_names_refseq": "kynu", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase", "protein_names_refseq": "kynureninase", "tax_id": 7955, "disease": "hydroxykynureninuria (Disease Ontology:DOID:0112257)", "pathway": " (dre:100334830); (R-DRE-71240)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BA40", "ec_number_list": "3.7.1.3", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0030429 kynureninase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IQY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IQZ2-1", "uniprot_id": "ZDH13_DANRE", "mass": 71440.0, "length": 645, "protein_name": "Putative palmitoyltransferase ZDHHC13", "gene_name": "zdhhc13", "organism": "Zebrafish", "refseq_name": "putative palmitoyltransferase ZDHHC13", "refseq_ac": "NP_001008650", "gene_names_uniprotkb": "zdhhc13", "gene_names_refseq": "DHHC-13; fi22e09; wu:fb06e01; wu:fc39g10; wu:fi22e09; zdhhc13; zgc:101690", "protein_names_uniprotkb": "Putative palmitoyltransferase ZDHHC13; DHHC domain-containing protein 13; DHHC-13; Zinc finger DHHC domain-containing protein 13", "protein_names_refseq": "DHHC domain-containing protein 13; palmitoyltransferase ZDHHC13; putative palmitoyltransferase ZDHHC13; zinc finger DHHC domain-containing protein 13; zinc finger DHHC-type containing 13; zinc finger DHHC-type palmitoyltransferase 13", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dre:494107)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26056731;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01007406.1, GDQH01002717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Dec 3, 2011 this sequence version replaced NP_001008650.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Putative palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PRB8", "ec_number_list": "", "go_molecular_function": "GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0030510 regulation of BMP signaling pathway;GO:0042665 regulation of ectodermal cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IQZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IR84-1", "uniprot_id": "A0A0R4IR84_DANRE", "mass": 101606.0, "length": 886, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "gene_name": "ndst1b", "organism": "Zebrafish", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1b", "refseq_ac": "NP_001311384", "gene_names_uniprotkb": "ndst1b; fj47c03; ndst1; wu:fj47c03", "gene_names_refseq": "fj47c03; ndst1b; ndst1; wu:fj47c03", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 1", "protein_names_refseq": "N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1b", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 46 (Disease Ontology:DOID:0081210); intellectual disability (Disease Ontology:DOID:1059); DiGeorge syndrome (Disease Ontology:DOID:11198); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (dre:570459); (R-DRE-2022928)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19858418;24643020;25767878;27189481;31269894;33068391;36503154", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01024377.1, SRR26395039.1759821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IP80;A0A8M1P7R8;A0AC58I9W5;A0AC58I9W6;A0AC58I9X2;A0AC58I9X3;A0AC58I9X6;A0AC58I9Y4;A0AC58I9Y9;A0AC58I9Z2;A0AC58I9Z3", "ec_number_list": "2.8.2.8", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0051923 sulfation;GO:0001570 vasculogenesis;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IR84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IRM1-1", "uniprot_id": "A0A0R4IRM1_DANRE", "mass": 109021.0, "length": 959, "protein_name": "Kinesin-like protein", "gene_name": "kif5ba", "organism": "Zebrafish", "refseq_name": "kinesin-1 heavy chain", "refseq_ac": "XP_002664065", "gene_names_uniprotkb": "kif5ba; kif5bb", "gene_names_refseq": "kif5bb", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-1 heavy chain", "tax_id": 7955, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:334108); (dre:563459)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RHK3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005737 cytoplasm;GO:0005871 kinesin complex;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0060349 bone morphogenesis;GO:0007281 germ cell development;GO:0051216 cartilage development;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IRM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IT00-1", "uniprot_id": "A0A0R4IT00_DANRE", "mass": 37043.0, "length": 320, "protein_name": "Elongation of very long chain fatty acids protein 1", "gene_name": "elovl1b", "organism": "Zebrafish", "refseq_name": "elongation of very long chain fatty acids protein 1b", "refseq_ac": "NP_001315523", "gene_names_uniprotkb": "elovl1b; ELOVL1; wu:fj32h05; zgc:56567", "gene_names_refseq": "elovl1b; wu:fj32h05; zgc:56567", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 1; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1", "protein_names_refseq": "elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b; elongation of very long chain fatty acids protein 1b", "tax_id": 7955, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (dre:406725); (R-DRE-2046105); (R-DRE-2046106); (R-DRE-75876)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "22438865;24947308;27078170;27189481;33690217;34849471;36075325;39528516", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1462979.1, SRR26395014.911988.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1, EH505140.1 and EH603421.1. On Jun 18, 2016 this sequence version replaced XP_009304163.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PF52;A0AC58GPY8", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001822 kidney development;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0R4IT00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IT86-1", "uniprot_id": "A0A0R4IT86_DANRE", "mass": 81947.0, "length": 755, "protein_name": "Kirre like nephrin family adhesion molecule 3, like precursor", "gene_name": "kirrel3l", "organism": "Zebrafish", "refseq_name": "kirre like nephrin family adhesion molecule 3, like precursor", "refseq_ac": "NP_001092814", "gene_names_uniprotkb": "kirrel3l; cb33; kirrel3; sb:cb33; si:dkey-29g23.1; wu:fb74e02", "gene_names_refseq": "cb33; kirrel3l; kirrel3; sb:cb33; si:dkey-29g23.1; wu:fb74e02", "protein_names_uniprotkb": "Kirre like nephrin family adhesion molecule 3, like precursor", "protein_names_refseq": "Neph2c; kin of IRRE like 3 like; kirre like nephrin family adhesion molecule 3, like precursor; kirrel2; neph3", "tax_id": 7955, "disease": "", "pathway": " (dre:557315); (R-DRE-373753)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16750657;17529975;20233749;20802085;20935258;22180726;22286130;24631215;28252024;30315160", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01015268.1, EF571006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Sep 8, 2016 this sequence version replaced NP_001092814.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NF10", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007520 myoblast fusion;GO:0072015 podocyte development;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IT86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IUF0-1", "uniprot_id": "A0A0R4IUF0_DANRE", "mass": 176778.0, "length": 1570, "protein_name": "DNA topoisomerase 2", "gene_name": "top2a", "organism": "Zebrafish", "refseq_name": "DNA topoisomerase 2-alpha", "refseq_ac": "NP_001296944", "gene_names_uniprotkb": "top2a; fc08c07; wu:fc08c07", "gene_names_refseq": "fc08c07; top2a; wu:fc08c07", "protein_names_uniprotkb": "DNA topoisomerase 2; 5.6.2.2", "protein_names_refseq": "DNA topoisomerase 2-alpha; topoisomerase (DNA) II alpha; topoisomerase 2", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); penile benign neoplasm (Disease Ontology:DOID:11624); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); nephroblastoma (Disease Ontology:DOID:2154); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:323733); (R-DRE-4615885)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15256591;16109975;16455309;17242348;19139076;34688465;36417527;36513650;36644807;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01029878.1, GDQH01005796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1, EB928159.1, EH541591.1 and EH551427.1. On Jun 21, 2015 this sequence version replaced XP_009304762.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7U6", "ec_number_list": "5.6.2.2;2.3.2.27;2.3.2.-", "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007059 chromosome segregation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0031100 animal organ regeneration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IUF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVP0-1", "uniprot_id": "A0A0R4IVP0_DANRE", "mass": 50485.0, "length": 441, "protein_name": "3.4.13.9; Oxysterols receptor LXR-alpha", "gene_name": "nr1h3", "organism": "Zebrafish", "refseq_name": "oxysterols receptor LXR-alpha", "refseq_ac": "NP_001017545", "gene_names_uniprotkb": "nr1h3; im:7141239; wu:fd59b01; zgc:113339; zgc:158542", "gene_names_refseq": "im:7141239; nr1h3; wu:fd59b01; zgc:113339; zgc:158542", "protein_names_uniprotkb": "3.4.13.9; Oxysterols receptor LXR-alpha", "protein_names_refseq": "LXRalpha; liver X receptor; lxr; oxysterols receptor LXR-alpha", "tax_id": 7955, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); carotid stenosis (Disease Ontology:DOID:13001); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:548341); (R-DRE-383280); (R-DRE-4090294); (R-DRE-9029569); (R-DRE-9623433)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "17997606;18297735;18395439;19416695;19451134;34831364;34878094;34942454;36835354;38697957", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092160.1, SRR32588717.57119976.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On or before Jan 28, 2016 this sequence version replaced XP_009301489.1, NP_001017545.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N4V7", "ec_number_list": "3.5.1.98;3.4.13.9;7.6.2.1;2.3.2.-", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0102009 proline dipeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:1904729 regulation of intestinal lipid absorption;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IVP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IWI1-1", "uniprot_id": "COE1A_DANRE", "mass": 64371.0, "length": 591, "protein_name": "Transcription factor COE1-A", "gene_name": "ebf1a; ebf3a", "organism": "Zebrafish", "refseq_name": "transcription factor COE1-A isoform 1", "refseq_ac": "NP_001410899", "gene_names_uniprotkb": "ebf1a; ebf3a; ebf3; sb:eu427; si:ch73-38f1.1; zgc:158829", "gene_names_refseq": "ebf1a; sb:eu427; si:ch73-38f1.1", "protein_names_uniprotkb": "Transcription factor COE1-A; Early B cell factor 1-A", "protein_names_refseq": "early B cell factor 1-A; early B cell factor 1a; transcription factor COE1-A isoform 1; transcription factor COE1-A; transcription factor COE1", "tax_id": 7955, "disease": "hypotonia, ataxia, and delayed development syndrome (Disease Ontology:DOID:0081176); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (dre:565310)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;30045885;34667153;36414621;38017520", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.30964552.1, SRR32588725.35229425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Aug 23, 2023 this sequence version replaced XP_009289484.1., [RefSeq]; Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional activator., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IW26;A0A0R4IWS1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IWI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IWI7-1", "uniprot_id": "A0A0R4IWI7_DANRE", "mass": 117738.0, "length": 1033, "protein_name": "Kinesin family member 5Aa", "gene_name": "kif5aa", "organism": "Zebrafish", "refseq_name": "kinesin family member 5Aa", "refseq_ac": "NP_001186705", "gene_names_uniprotkb": "kif5aa; kif5a; si:ch211-166e11.4; vertigo; vrt; wu:fj61a10", "gene_names_refseq": "kif5aa; kif5a; si:ch211-166e11.4; vertigo; vrt; wu:fj61a10", "protein_names_uniprotkb": "Kinesin family member 5Aa", "protein_names_refseq": "kinesin family member 5Aa", "tax_id": 7955, "disease": "amyotrophic lateral sclerosis type 25 (Disease Ontology:DOID:0081379); hereditary spastic paraplegia 10 (Disease Ontology:DOID:0110763); prostate cancer (Disease Ontology:DOID:10283); multiple sclerosis (Disease Ontology:DOID:2377); rheumatoid arthritis (Disease Ontology:DOID:7148); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (dre:566086); (R-DRE-5625970); (R-DRE-983189)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "23684767;24179142;25355224;26076409;26957310;27189481;28193224;36459488", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014007.1, SRR26395015.206512.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC095088.1 and JBMGRA010000009.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Our results shed light on Kinesin complexity and reveal determinants of specific Kif5A functions in mitochondrial transport, adaptor binding, and axonal maintenance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NWH1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0032839 dendrite cytoplasm;GO:1904115 axon cytoplasm", "go_biological_process": "GO:1990535 neuron projection maintenance;GO:0007411 axon guidance;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0048489 synaptic vesicle transport;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0R4IWI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IZT6-1", "uniprot_id": "A0A0R4IZT6_DANRE", "mass": 37083.0, "length": 323, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "ppp1cc", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase PP1-gamma catalytic subunit A", "refseq_ac": "XP_700468", "gene_names_uniprotkb": "ppp1cc", "gene_names_refseq": "ppp1cc", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "serine/threonine-protein phosphatase PP1-gamma catalytic subunit A", "tax_id": 7955, "disease": "", "pathway": " (dre:571753); (R-DRE-141430); (R-DRE-141444); (R-DRE-180024); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220); (R-DRE-5673000); (R-DRE-9770562)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_700468.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T728", "ec_number_list": "3.1.3.16;3.1.3.48;2.7.7.6;2.7.11.1;3.1.3.67;3.1.3.27;2.7.7.19;3.6.4.12;2.3.2.27;2.7.1.78;3.6.4.13;2.7.7.52", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032154 cleavage furrow", "go_biological_process": "GO:0001525 angiogenesis;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IZT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A140LFM6-1", "uniprot_id": "MNAR1_DANRE", "mass": 101179.0, "length": 897, "protein_name": "Major intrinsically disordered Notch2-binding receptor 1", "gene_name": "minar1", "organism": "Zebrafish", "refseq_name": "major intrinsically disordered Notch2-binding receptor 1", "refseq_ac": "NP_001410772", "gene_names_uniprotkb": "minar1; kiaa1024; si:cabz01029535.1; ubtora; ubtor", "gene_names_refseq": "kiaa1024; minar1; si:cabz01029535.1; ubtor", "protein_names_uniprotkb": "Major intrinsically disordered Notch2-binding receptor 1; Membrane integral NOTCH2-associated receptor 1; Ubiquitination and mTOR signaling protein; ubtor", "protein_names_refseq": "major intrinsically disordered Notch2-binding receptor 1; ubiquitination and mTOR signaling protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100331504)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23594743;27189481;30080879;34309811;36317962", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01016937.1, SRR32588722.35133675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505393, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000007.1. On Aug 16, 2023 this sequence version replaced XP_002667438.1., [RefSeq]; Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). May play a role in neuronal development (PubMed:30080879)., [UniProtKB, UniProtKB, PubMed]; Ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010977 negative regulation of neuron projection development;GO:0030308 negative regulation of cell growth;GO:0032007 negative regulation of TOR signaling;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A140LFM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1L2F565-1", "uniprot_id": "PTH4_DANRE", "mass": 13799.0, "length": 121, "protein_name": "Parathyroid hormone 4", "gene_name": "pth4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pth4; PTH-L; pthl", "gene_names_refseq": "", "protein_names_uniprotkb": "Parathyroid hormone 4", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:101886149)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22768871;23594743;25841489;28148780;29040309;29062283;33268890", "class_list": "", "function": "Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G protein-coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286YAB1", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0002076 osteoblast development;GO:0032330 regulation of chondrocyte differentiation;GO:0030500 regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A1L2F565-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286Y9Q6-1", "uniprot_id": "A0A286Y9Q6_DANRE", "mass": 99760.0, "length": 883, "protein_name": "Glutamate receptor", "gene_name": "gria3b", "organism": "Zebrafish", "refseq_name": "glutamate receptor 3b isoform X1", "refseq_ac": "XP_005157190", "gene_names_uniprotkb": "gria3b; AMPA; GRIN3A; SI:zC231H1.1; glur3b; gria3.2; gria3; si:bz1o18.1; si:zc140k5.3; zfGRIA3[b]", "gene_names_refseq": "AMPA; GRIN3A; SI:zC231H1.1; glur3b; gria3.2; gria3b; gria3; si:bz1o18.1; si:zc140k5.3; zfGRIA3[b]", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor 3b isoform X1", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability 94 (Disease Ontology:DOID:0060823); neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-DRE-399710); (R-DRE-416993); (R-DRE-438066); (R-DRE-8849932)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B408", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0022824 transmitter-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A286Y9Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YA30-1", "uniprot_id": "A0A286YA30_DANRE", "mass": 44497.0, "length": 398, "protein_name": "Renin receptor", "gene_name": "atp6ap2", "organism": "Zebrafish", "refseq_name": "renin receptor isoform X1", "refseq_ac": "XP_009294369", "gene_names_uniprotkb": "atp6ap2; wu:fj36c03; wu:fq15e04; zgc:73194", "gene_names_refseq": "atp6ap2; wu:fj36c03; wu:fq15e04; zgc:73194", "protein_names_uniprotkb": "Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor", "protein_names_refseq": "renin receptor isoform X1", "tax_id": 7955, "disease": "congenital disorder of glycosylation type IIr (Disease Ontology:DOID:0051048); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); X-linked parkinsonism-spasticity syndrome (Disease Ontology:DOID:0112105)", "pathway": " (dre:406296); (R-DRE-2022377); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "22465374;26469318;27189481;28252024;31042481;32328632;34550070;34936864;35088848", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AUI7", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009897 external side of plasma membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0035622 intrahepatic bile duct development;GO:0030177 positive regulation of Wnt signaling pathway;GO:0045176 apical protein localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A286YA30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P1W1-1", "uniprot_id": "A0A8M9P1W1_DANRE", "mass": 544827.0, "length": 4778, "protein_name": "Plectin", "gene_name": "pleca", "organism": "Zebrafish", "refseq_name": "plectin a isoform X1", "refseq_ac": "XP_021323777", "gene_names_uniprotkb": "pleca; fa95h11; plec1-like; sb:eu420; si:dkey-151c10.1; wu:fa95h11", "gene_names_refseq": "fa95h11; plec1-like; pleca; sb:eu420; si:dkey-151c10.1; wu:fa95h11", "protein_names_uniprotkb": "Plectin; Plectin-1", "protein_names_refseq": "plectin a isoform X1", "tax_id": 7955, "disease": "epidermolysis bullosa simplex 5A Ogna type (Disease Ontology:DOID:0060736); epidermolysis bullosa simplex with muscular dystrophy (Disease Ontology:DOID:0090017); autosomal recessive limb-girdle muscular dystrophy type 2Q (Disease Ontology:DOID:0110285); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (dre:567639)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21191402;25556858;25866181;26469318;28211472;29809138;32146360;34572100;36003151;37393735", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0002102 podosome;GO:0030056 hemidesmosome;GO:0030057 desmosome", "go_biological_process": "GO:0007507 heart development;GO:0061436 establishment of skin barrier;GO:0060047 heart contraction;GO:0045104 intermediate filament cytoskeleton organization;GO:0002934 desmosome organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9P1W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q3S9-1", "uniprot_id": "CLCC1_DANRE", "mass": 69946.0, "length": 609, "protein_name": "Chloride channel CLIC-like protein 1", "gene_name": "clcc1", "organism": "Zebrafish", "refseq_name": "chloride channel CLIC-like protein 1 isoform X1", "refseq_ac": "XP_009294671", "gene_names_uniprotkb": "clcc1; unm_sa44388", "gene_names_refseq": "clcc1; unm_sa44388", "protein_names_uniprotkb": "Chloride channel CLIC-like protein 1", "protein_names_refseq": "chloride channel CLIC-like protein 1 isoform X1", "tax_id": 7955, "disease": "retinitis pigmentosa 32 (Disease Ontology:DOID:0110355)", "pathway": " (dre:100332460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;30157172", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (PubMed:30157172)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005254 chloride channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A2R8Q3S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q685-1", "uniprot_id": "A0A2R8Q685_DANRE", "mass": 93242.0, "length": 834, "protein_name": "Potassium voltage-gated channel subfamily B member 1", "gene_name": "kcnb1", "organism": "Zebrafish", "refseq_name": "potassium voltage-gated channel subfamily B member 1", "refseq_ac": "XP_682848", "gene_names_uniprotkb": "kcnb1", "gene_names_refseq": "kcnb1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 26 (Disease Ontology:DOID:0080461); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:555284); (R-DRE-381676)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_682848.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TAC7", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0021591 ventricular system development;GO:0006887 exocytosis;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QC01-1", "uniprot_id": "A0A2R8QC01_DANRE", "mass": 60009.0, "length": 526, "protein_name": "ETS translocation variant 5b isoform 1", "gene_name": "etv5b", "organism": "Zebrafish", "refseq_name": "ETS translocation variant 5b isoform 1", "refseq_ac": "NP_001296138", "gene_names_uniprotkb": "etv5b; cb805; erm1; erm; wu:fe05h04; wu:fj66a04", "gene_names_refseq": "cb805; erm1; erm; etv5b; wu:fe05h04; wu:fj66a04", "protein_names_uniprotkb": "ETS translocation variant 5b isoform 1", "protein_names_refseq": "ETS translocation variant 5b isoform 1; ets related protein erm", "tax_id": 7955, "disease": "", "pathway": " (dre:30452)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10534622;11413000;11520667;12135921;23250211;37272628;37334313;37642135;37665167;37819938", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC060924.1, SRR26395013.370669.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1, EH470800.1, CT594467.2 and CT717580.2. On May 21, 2015 this sequence version replaced XP_005165915.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P213", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007346 regulation of mitotic cell cycle;GO:0045893 positive regulation of DNA-templated transcription;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8QC01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QFQ6-1", "uniprot_id": "FB11A_DANRE", "mass": 64108.0, "length": 562, "protein_name": "F-box and WD repeat domain-containing 11-A", "gene_name": "fbxw11a", "organism": "Zebrafish", "refseq_name": "F-box and WD repeat domain-containing 11-A", "refseq_ac": "NP_958467", "gene_names_uniprotkb": "fbxw11a", "gene_names_refseq": "btrc2; fbxw11a; fbxw11b; fbxw11; fbxw1b; wu:fd14d12; wu:fi43f07", "protein_names_uniprotkb": "F-box and WD repeat domain-containing 11-A", "protein_names_refseq": "F-box and WD repeat domain-containing 11-A; F-box and WD-40 domain protein 11a; F-box and WD-40 domain protein 11; F-box/WD repeat-containing protein 11a", "tax_id": 7955, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (dre:334373)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31402090", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045356.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045356.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZVZ1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032040 small-subunit processome", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A2R8QFQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QP51-1", "uniprot_id": "DPP9_DANRE", "mass": 101281.0, "length": 885, "protein_name": "Dipeptidyl peptidase 9", "gene_name": "dpp9", "organism": "Zebrafish", "refseq_name": "dipeptidyl peptidase 9", "refseq_ac": "NP_001070781", "gene_names_uniprotkb": "dpp9; im:7145318; zgc:152900", "gene_names_refseq": "dpp9; im:7145318; zgc:152900", "protein_names_uniprotkb": "Dipeptidyl peptidase 9; 3.4.14.5", "protein_names_refseq": "dipeptidyl peptidase 9", "tax_id": 7955, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (dre:768170)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;36112693;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124602.1, GDQH01004822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jan 23, 2009 this sequence version replaced NP_001070781.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling., [RefSeq, PubMed]; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (By similarity). Acts as a key inhibitor of the NLRP1 inflammasome (PubMed:36112693)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NBI9", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006508 proteolysis;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A2R8QP51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RWN9-1", "uniprot_id": "FB11B_DANRE", "mass": 61462.0, "length": 534, "protein_name": "F-box and WD repeat domain-containing 11-B", "gene_name": "fbxw11b", "organism": "Zebrafish", "refseq_name": "F-box and WD repeat domain-containing 11-B", "refseq_ac": "NP_998669", "gene_names_uniprotkb": "fbxw11b; btrc2; fbxw11a; wu:fa12e12; wu:fb11f03; zgc:63728", "gene_names_refseq": "btrc2; fbxw11a; fbxw11b; wu:fa12e12; wu:fb11f03; zgc:63728", "protein_names_uniprotkb": "F-box and WD repeat domain-containing 11-B", "protein_names_refseq": "F-box and WD repeat domain-containing 11-B; F-box and WD-40 domain protein 11b; F-box/WD repeat-containing protein 11b; fbxw11", "tax_id": 7955, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (dre:406825)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31402090", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056809.1. On Sep 30, 2011 this sequence version replaced NP_998669.1. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PGW4", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0002040 sprouting angiogenesis;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A2R8RWN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEF6-1", "uniprot_id": "A0A8M2BEF6_DANRE", "mass": 168951.0, "length": 1500, "protein_name": "DNA (cytosine-5-)-methyltransferase", "gene_name": "dnmt3ba", "organism": "Zebrafish", "refseq_name": "DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1", "refseq_ac": "XP_005167049", "gene_names_uniprotkb": "dnmt3ba; cb91; dnmt3b2; dnmt3bl; dnmt3b; dnmt7; sb:cb91; wu:fb16h07", "gene_names_refseq": "cb91; dnmt3b2; dnmt3ba; dnmt3bl; dnmt3b; dnmt7; sb:cb91; wu:fb16h07", "protein_names_uniprotkb": "DNA (cytosine-5-)-methyltransferase; 2.1.1.37", "protein_names_refseq": "DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); facioscapulohumeral muscular dystrophy 4 (Disease Ontology:DOID:0060918); immunodeficiency-centromeric instability-facial anomalies syndrome 1 (Disease Ontology:DOID:0090008); lung cancer (Disease Ontology:DOID:1324); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); thymoma (Disease Ontology:DOID:3275); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); gastric body carcinoma (Disease Ontology:DOID:6705); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic myeloid leukemia (Disease Ontology:DOID:8552); skin melanoma (Disease Ontology:DOID:8923); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:321084)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12949138;15937923;21258815;21468032;22450363;36945831;37980044;38182651;39010883;39110393", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G664;E7F6H4", "ec_number_list": "", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0009008 DNA-methyltransferase activity;GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "go_cellular_component": "GO:0005634 nucleus;GO:0005874 microtubule", "go_biological_process": "GO:0051301 cell division;GO:0032259 methylation;GO:0061371 determination of heart left/right asymmetry;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BEF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N1X8-1", "uniprot_id": "A0A8M1N1X8_DANRE", "mass": 146713.0, "length": 1267, "protein_name": "Unconventional myosin-VI", "gene_name": "myo6b", "organism": "Zebrafish", "refseq_name": "myosin VIb", "refseq_ac": "NP_001004110", "gene_names_uniprotkb": "myo6b", "gene_names_refseq": "myo6b", "protein_names_uniprotkb": "Unconventional myosin-VI; Unconventional myosin-6", "protein_names_refseq": "myosin VIb; sai; satellite", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 37 (Disease Ontology:DOID:0110495); autosomal dominant nonsyndromic deafness 22 (Disease Ontology:DOID:0110552); sensorineural hearing loss (Disease Ontology:DOID:10003); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dre:445472)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15282151;15317943;15520368;16285850;17606911;36317962;36543769;36598134;36912880;38492873", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY618701.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY618701.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Is required for maintaining the integrity of the apical surface of hair cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0021782 glial cell development;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N1X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N5Y4-1", "uniprot_id": "TMX3A_DANRE", "mass": 49077.0, "length": 437, "protein_name": "Protein disulfide-isomerase tmx3a", "gene_name": "tmx3a", "organism": "Zebrafish", "refseq_name": "protein disulfide-isomerase tmx3a precursor", "refseq_ac": "NP_001018393", "gene_names_uniprotkb": "tmx3a; tmx3; txndc10; zgc:110025", "gene_names_refseq": "tmx3a; tmx3; txndc10; zgc:110025", "protein_names_uniprotkb": "Protein disulfide-isomerase tmx3a; 5.3.4.1", "protein_names_refseq": "protein disulfide-isomerase TMX3a; protein disulfide-isomerase tmx3a precursor; thioredoxin domain containing 10; thioredoxin-related transmembrane protein 3", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "20485507;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095139.1, BC164528.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095139.1. On Sep 30, 2011 this sequence version replaced NP_001018393.1., [RefSeq]; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q503X6", "ec_number_list": "", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1N5Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N8U6-1", "uniprot_id": "A0A8M1N8U6_DANRE", "mass": 91846.0, "length": 834, "protein_name": "Suppressor of tumorigenicity 14 protein homolog", "gene_name": "st14a", "organism": "Zebrafish", "refseq_name": "ST14 transmembrane serine protease matriptase a", "refseq_ac": "NP_001035441", "gene_names_uniprotkb": "st14a; mat1a; st14; wu:fi41g07; wu:fl72f01; zgc:136950; zgc:152656; zgc:152657", "gene_names_refseq": "mat1a; st14a; st14; wu:fi41g07; wu:fl72f01; zgc:136950; zgc:152656; zgc:152657", "protein_names_uniprotkb": "Suppressor of tumorigenicity 14 protein homolog; 3.4.21.109; Serine protease 14", "protein_names_refseq": "ST14 transmembrane serine protease matriptase a; epithin; matriptase 1a; suppression of tumorigenicity 14 (colon carcinoma) a; suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); suppression of tumorigenicity 14a", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal recessive congenital ichthyosis 11 (Disease Ontology:DOID:0060720); Sjogren's syndrome (Disease Ontology:DOID:12894); granulosa cell tumor (Disease Ontology:DOID:2999); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:678603)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16109975;17273967;17728346;17881499;21657981;30061596;31645615;31819976;34165081;37566613;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115342.1, BC124578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115342.1. On Oct 8, 2011 this sequence version replaced NP_001035441.1. Sequence Note: This RefSeq record was created from a transcript of a different strain than the reference genome strain because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase., [RefSeq, PubMed]; Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the live imaging of chronic inflammation caused by mutation of zebrafish Hai1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0009566 fertilization;GO:0016485 protein processing;GO:0008544 epidermis development;GO:0098743 cell aggregation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1N8U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N978-1", "uniprot_id": "A0A8M1N978_DANRE", "mass": 142310.0, "length": 1265, "protein_name": "Myosin-binding protein C, fast-type", "gene_name": "mybpc3", "organism": "Zebrafish", "refseq_name": "myosin-binding protein C, cardiac-type", "refseq_ac": "NP_001037814", "gene_names_uniprotkb": "mybpc3; hm:zehn0716; im:6900815; zgc:152717; zgc:158442", "gene_names_refseq": "hm:zehn0716; im:6900815; mybpc3; zgc:152717; zgc:158442", "protein_names_uniprotkb": "Myosin-binding protein C, fast-type; C-protein, skeletal muscle fast isoform", "protein_names_refseq": "myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type", "tax_id": 7955, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); dilated cardiomyopathy 1MM (Disease Ontology:DOID:0081158); hypertrophic cardiomyopathy 4 (Disease Ontology:DOID:0110310); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:556489)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11116087;17606911;18256191;22116938;36367103;36613558;38181896;38533084;39300306;9409775", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476745, SAMEA4476807 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC107633.1, CN179233.1, EB896522.1, EB897596.1, EB897718.1, EB890884.1, CO930551.1, DT081938.1 and EB892846.1. On Apr 4, 2008 this sequence version replaced NP_001037814.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0032982 myosin filament", "go_biological_process": "GO:0007155 cell adhesion;GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0002027 regulation of heart rate;GO:0055010 ventricular cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N978-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NBP6-1", "uniprot_id": "A0A8M1NBP6_DANRE", "mass": 223313.0, "length": 1936, "protein_name": "Myosin-7", "gene_name": "myh7l", "organism": "Zebrafish", "refseq_name": "myosin heavy chain 7-like", "refseq_ac": "NP_001070932", "gene_names_uniprotkb": "myh7l; Myh1; vmhcl; zgc:113832; zgc:152732", "gene_names_refseq": "Myh1; myh7l; vmhcl; zgc:113832; zgc:152732", "protein_names_uniprotkb": "Myosin-7; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform", "protein_names_refseq": "myosin heavy chain 7-like; ventricular myosin heavy chain-like", "tax_id": 7955, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); distal myopathy 1 (Disease Ontology:DOID:0070197); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal recessive hyaline body myopathy (Disease Ontology:DOID:0111268); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); congenital heart disease (Disease Ontology:DOID:1682); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (dre:768300)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19679566;22624717;25010986;25583992;26469318;37009226;37650323;38334702;38412038;38533084", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC096949.1, EB889739.1, EB890977.1, EB884317.1, EB896917.1, EB887670.1 and BC150349.1. On Dec 20, 2007 this sequence version replaced NP_001070932.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030017 sarcomere;GO:0032982 myosin filament;GO:0016460 myosin II complex", "go_biological_process": "GO:0003231 cardiac ventricle development;GO:0030049 muscle filament sliding;GO:0060048 cardiac muscle contraction;GO:0010611 regulation of cardiac muscle hypertrophy;GO:0007512 adult heart development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NBP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHJ9-1", "uniprot_id": "A0A8M3AHJ9_DANRE", "mass": 63366.0, "length": 546, "protein_name": "Inositol polyphosphate 5-phosphatase Ka isoform X1", "gene_name": "inpp5ka", "organism": "Zebrafish", "refseq_name": "inositol polyphosphate 5-phosphatase Ka isoform X1", "refseq_ac": "XP_009290059", "gene_names_uniprotkb": "inpp5ka; inpp5k; zgc:162883", "gene_names_refseq": "inpp5ka; inpp5k; zgc:162883", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase Ka isoform X1", "protein_names_refseq": "inositol polyphosphate 5-phosphatase Ka isoform X1", "tax_id": 7955, "disease": "muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); congenital muscular dystrophy with cataracts and intellectual disability (Disease Ontology:DOID:0080197)", "pathway": " (dre:100037338)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "27189481;27458029;27773705;28190456;28190459;28940338;33792664;37184573", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0016791 phosphatase activity;GO:0016312 inositol bisphosphate phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0046030 inositol trisphosphate phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0001726 ruffle", "go_biological_process": "GO:0048741 skeletal muscle fiber development;GO:0046856 phosphatidylinositol dephosphorylation;GO:0098529 neuromuscular junction development, skeletal muscle fiber;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M3AHJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NI50-1", "uniprot_id": "A0A8M1NI50_DANRE", "mass": 52305.0, "length": 460, "protein_name": "Interferon regulatory factor 4a", "gene_name": "irf4a", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 4a", "refseq_ac": "NP_001116182", "gene_names_uniprotkb": "irf4a; si:ch73-170d1.2", "gene_names_refseq": "irf4a; si:ch73-170d1.2", "protein_names_uniprotkb": "Interferon regulatory factor 4a", "protein_names_refseq": "interferon regulatory factor 4a; irf4", "tax_id": 7955, "disease": "anaplastic large cell lymphoma (Disease Ontology:DOID:0050744); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); peripheral T-cell lymphoma (Disease Ontology:DOID:0050749); follicular lymphoma (Disease Ontology:DOID:0050873); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); immunodeficiency 131 (Disease Ontology:DOID:0061125); pigmentation disease (Disease Ontology:DOID:10123); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); middle cerebral artery infarction (Disease Ontology:DOID:3525); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:100002070)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18039395;20333216;20444275;20883793;21272652;32198141;32489338;33077646;33530637;35300694", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01055136.1, GFIL01013489.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Mar 17, 2008 this sequence version replaced XP_001341945.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8B8L1", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002320 lymphoid progenitor cell differentiation;GO:0045638 negative regulation of myeloid cell differentiation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NI50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NJ75-1", "uniprot_id": "A0A8M1NJ75_DANRE", "mass": 83023.0, "length": 752, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "acsbg2", "organism": "Zebrafish", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG2", "refseq_ac": "NP_001119851", "gene_names_uniprotkb": "acsbg2; fj55d04; fk81d02; im:7046047; sb:cb76; si:dkey-240a9.3; wu:fj55d04; wu:fk81d02", "gene_names_refseq": "acsbg2; fj55d04; fk81d02; im:7046047; sb:cb76; si:dkey-240a9.3; wu:fj55d04; wu:fk81d02", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG2; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase ACSBG2", "tax_id": 7955, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (dre:335159)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17762044;22438865;26469318;32325903;34016526", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.1550200.1, SRR32588731.930682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Aug 26, 2009 this sequence version replaced XP_686467.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1NJ75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NUM7-1", "uniprot_id": "A0A8M1NUM7_DANRE", "mass": 83240.0, "length": 740, "protein_name": "Fibroblast growth factor receptor", "gene_name": "fgfr1b", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor receptor 1b precursor", "refseq_ac": "NP_001155204", "gene_names_uniprotkb": "fgfr1b; si:ch211-180b9.1", "gene_names_refseq": "fgfr1b; si:ch211-180b9.1", "protein_names_uniprotkb": "Fibroblast growth factor receptor; 2.7.10.1", "protein_names_refseq": "fibroblast growth factor receptor 1b precursor", "tax_id": 7955, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atypical chronic myeloid leukemia, BCR-ABL1 negative (Disease Ontology:DOID:0060597); myeloid neoplasm (Disease Ontology:DOID:0070004); bone disease (Disease Ontology:DOID:0080001); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 2 with or without anosmia (Disease Ontology:DOID:0090083); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); osteoglophonic dysplasia (Disease Ontology:DOID:0111532); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); acrocephalosyndactylia (Disease Ontology:DOID:12960); Pfeiffer syndrome (Disease Ontology:DOID:14705); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mouth disease (Disease Ontology:DOID:403); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); fibrolamellar carcinoma (Disease Ontology:DOID:5015); retinal detachment (Disease Ontology:DOID:5327); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:567905)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18296487;19733072;20802085;20935258;23350700;33039926;34666023;36444384;36458546;36841347", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505377 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000010.1. On Jun 12, 2009 this sequence version replaced XP_696307.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045597 positive regulation of cell differentiation;GO:0051216 cartilage development;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NUM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKD3-1", "uniprot_id": "A0A8M2BKD3_DANRE", "mass": 33030.0, "length": 299, "protein_name": "Nucleophosmin", "gene_name": "npm1b", "organism": "Zebrafish", "refseq_name": "nucleophosmin 1b", "refseq_ac": "NP_001159627", "gene_names_uniprotkb": "npm1b; npm4", "gene_names_refseq": "npm1b; npm4", "protein_names_uniprotkb": "Nucleophosmin", "protein_names_refseq": "nucleophosmin 1b (nucleolar phosphoprotein B23, numatrin); nucleophosmin 1b; nucleophosmin/nucleoplasmin, 1b; nucleophosmin/nucleoplasmin, 4", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary ovarian insufficiency (Disease Ontology:DOID:5426); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:553507)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18541024;20197555;23598338;23734242;26469318;28432080", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC121757.1, GDQH01021986.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On or before Jul 31, 2025 this sequence version replaced XP_005173145.3, NP_001159627.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0030097 hemopoiesis;GO:0042981 regulation of apoptotic process;GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BKD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3D4-1", "uniprot_id": "A0A8M1P3D4_DANRE", "mass": 31948.0, "length": 277, "protein_name": "pyridoxal 5'-phosphate synthase", "gene_name": "pnpo", "organism": "Zebrafish", "refseq_name": "pyridoxine-5'-phosphate oxidase", "refseq_ac": "NP_001243107", "gene_names_uniprotkb": "pnpo; im:7138360", "gene_names_refseq": "im:7138360; pnpo", "protein_names_uniprotkb": "pyridoxal 5'-phosphate synthase; 1.4.3.5", "protein_names_refseq": "pyridoxine 5'-phosphate oxidase; pyridoxine-5'-phosphate oxidase", "tax_id": 7955, "disease": "pyridoxamine 5'-phosphate oxidase deficiency (Disease Ontology:DOID:0111329); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:402868)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "27189481;28252024;31616300;31759955;33836087;34083748;38924394", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC057246.1, GFIL01030831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jan 12, 2012 this sequence version replaced XP_688664.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010181 FMN binding;GO:0004733 pyridoxamine phosphate oxidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0036269 swimming behavior;GO:0009448 gamma-aminobutyric acid metabolic process;GO:0008615 pyridoxine biosynthetic process;GO:0006544 glycine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M1P3D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3S4-1", "uniprot_id": "A0A8M1P3S4_DANRE", "mass": 29668.0, "length": 256, "protein_name": "Neurotrophin-3", "gene_name": "ntf3", "organism": "Zebrafish", "refseq_name": "neurotrophin-3", "refseq_ac": "NP_001314742", "gene_names_uniprotkb": "ntf3; NT-3; wu:fl98d04", "gene_names_refseq": "NT-3; ntf3; wu:fl98d04", "protein_names_uniprotkb": "Neurotrophin-3; NT-3", "protein_names_refseq": "neurotrophin-3", "tax_id": 7955, "disease": "atrial heart septal defect 1 (Disease Ontology:DOID:0110106); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dre:386825)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10708902;11023682;16109975;20701988;26076409;32050064;32862360;35737348;36059461;38089055", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092731.1, GDQH01027673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jun 25, 2025 this sequence version replaced NP_001314742.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0007422 peripheral nervous system development;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P3S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P467-1", "uniprot_id": "A0A8M1P467_DANRE", "mass": 14732.0, "length": 127, "protein_name": "Agouti-related protein", "gene_name": "agrp", "organism": "Zebrafish", "refseq_name": "agouti-related protein precursor", "refseq_ac": "NP_001314941", "gene_names_uniprotkb": "agrp; agrp1; si:dkey-193l8.2", "gene_names_refseq": "agrp1; agrp; si:dkey-193l8.2", "protein_names_uniprotkb": "Agouti-related protein", "protein_names_refseq": "agouti related protein homolog; agouti-related protein precursor", "tax_id": 7955, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100149042)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14709799;15891063;17341684;18728227;19504458;36472402;36801393;37495865;39471229;39519205", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH458154.1, SRR32588723.3791945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 3, 2016 this sequence version replaced XP_001923939.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland. Involved in the control of feeding behavior via the central melanocortin system. Has very low activity towards MC5R. Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QM92;A0AC58FXR1", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0040008 regulation of growth;GO:0007631 feeding behavior;GO:0008343 adult feeding behavior;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P5N0-1", "uniprot_id": "A0A8M1P5N0_DANRE", "mass": 36056.0, "length": 321, "protein_name": "Epiphycan isoform 2 precursor; Epiphycan isoform X2", "gene_name": "epyc", "organism": "Zebrafish", "refseq_name": "epiphycan isoform 1 precursor", "refseq_ac": "NP_001335412", "gene_names_uniprotkb": "epyc; dspg3; im:6901189; si:dkeyp-38g8.4; wu:fb48c08; zgc:110596", "gene_names_refseq": "dspg3; epyc; im:6901189; si:dkeyp-38g8.4; wu:fb48c08; zgc:110596", "protein_names_uniprotkb": "Epiphycan isoform 2 precursor; Epiphycan isoform X2", "protein_names_refseq": "dspg3l; epiphycan isoform 1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:550602)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16458084;20802085;20935258;24608635;25617839;26469318;27189481;30174136;33501917;37884489", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092942.1, SRR32588723.739995.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RI46", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P5N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P6J4-1", "uniprot_id": "A0A8M1P6J4_DANRE", "mass": 54091.0, "length": 476, "protein_name": "interstitial collagenase", "gene_name": "mmp13a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mmp13a; cb1034; mmp13", "gene_names_refseq": "", "protein_names_uniprotkb": "interstitial collagenase; 3.4.24.7", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:387293)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15937927;16112664;16815100;16885356;16999953;37650323;37748761;38311285;38431640;38485506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P6J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P7F8-1", "uniprot_id": "A0A8M1P7F8_DANRE", "mass": 45897.0, "length": 408, "protein_name": "Endothelin-1 receptor", "gene_name": "ednrab", "organism": "Zebrafish", "refseq_name": "endothelin receptor type Ab precursor", "refseq_ac": "NP_001297024", "gene_names_uniprotkb": "ednrab; zgc:85942", "gene_names_refseq": "ednrab; zgc:85942", "protein_names_uniprotkb": "Endothelin-1 receptor; Endothelin receptor type A", "protein_names_refseq": "ednrA1; endothelin receptor type Ab precursor", "tax_id": 7955, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); mandibulofacial dysostosis with alopecia (Disease Ontology:DOID:0060365); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184); velocardiofacial syndrome (Disease Ontology:DOID:12583); impotence (Disease Ontology:DOID:1875); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:405866)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17166927;22241841;23951404;24424055;25058015;28096348;29358039;30561090;31782996;36367707", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588731.1313108.1, SRR32588723.2116200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W4W1", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0086100 endothelin receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0042310 vasoconstriction;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P7F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P874-1", "uniprot_id": "A0A8M1P874_DANRE", "mass": 41203.0, "length": 372, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "ppm1kb", "organism": "Zebrafish", "refseq_name": "protein phosphatase Mn(2+)-dependent 1K", "refseq_ac": "NP_001314673", "gene_names_uniprotkb": "ppm1kb; im:6912645; ppm1k; zgc:113207", "gene_names_refseq": "im:6912645; ppm1kb; ppm1k; zgc:113207", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "pp2cm; protein phosphatase 1K (PP2C domain containing); protein phosphatase Mn(2+)-dependent 1K; protein phosphatase, Mg2+/Mn2+ dependent, 1K", "tax_id": 7955, "disease": "mild variant of maple syrup urine disease (Disease Ontology:DOID:0061205); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (dre:503713); (R-DRE-70895)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17374715;21925157;24683187;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588717.42475035.1, SRR32588719.9923311.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH500508.1 and JBMGRA010000001.1. On May 25, 2016 this sequence version replaced XP_005160149.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R0V7", "ec_number_list": "3.1.3.16", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001889 liver development;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M1P874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PAD4-1", "uniprot_id": "A0A8M1PAD4_DANRE", "mass": 60732.0, "length": 535, "protein_name": "Tyrosinase", "gene_name": "tyr", "organism": "Zebrafish", "refseq_name": "tyrosinase precursor", "refseq_ac": "NP_571088", "gene_names_uniprotkb": "tyr; sandy; zgc:109705", "gene_names_refseq": "sandy; tyr; zgc:109705", "protein_names_uniprotkb": "Tyrosinase; 1.14.18.1; Monophenol monooxygenase", "protein_names_refseq": "oca1; sdy; tyra; tyrosinase precursor", "tax_id": 7955, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); ocular albinism 1 (Disease Ontology:DOID:0050633); oculocutaneous albinism type IA (Disease Ontology:DOID:0070094); oculocutaneous albinism type IB (Disease Ontology:DOID:0070095); pigmentation disease (Disease Ontology:DOID:10123); buphthalmos (Disease Ontology:DOID:11211); vitiligo (Disease Ontology:DOID:12306); color blindness (Disease Ontology:DOID:13399); melanoma (Disease Ontology:DOID:1909); retinoschisis (Disease Ontology:DOID:8465); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (dre:30207)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10818695;12486702;15300437;15486693;38652190;38874379;39141082;39225039;39496611;40044042;9007256", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF542067.1, SRR32588719.11126818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Jun 9, 2025 this sequence version replaced NP_571088.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004503 tyrosinase activity;GO:0004097 catechol oxidase activity", "go_cellular_component": "GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0006585 dopamine biosynthetic process from tyrosine;GO:0032438 melanosome organization;GO:0043473 pigmentation;GO:0042438 melanin biosynthetic process;GO:0048066 developmental pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1PAD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PGA4-1", "uniprot_id": "A0A8M1PGA4_DANRE", "mass": 54576.0, "length": 485, "protein_name": "[histone H3]-lysine(4) N-trimethyltransferase", "gene_name": "smyd1a", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SMYD1a", "refseq_ac": "NP_991103", "gene_names_uniprotkb": "smyd1a; sb:cb405; smyd1; wu:fc09a05; zgc:77936", "gene_names_refseq": "sb:cb405; smyd1a; smyd1; wu:fc09a05; zgc:77936", "protein_names_uniprotkb": "[histone H3]-lysine(4) N-trimethyltransferase; 2.1.1.354", "protein_names_refseq": "histone-lysine N-methyltransferase SMYD1a", "tax_id": 7955, "disease": "", "pathway": " (dre:321245)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;17024299;18231586;19211926;24068325;30817176;32843646;32988975;33789631;33958316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065475.1, GFIL01039076.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1 and EH601391.1. On Jun 10, 2015 this sequence version replaced NP_991103.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Smyd1a knockout had no visible effect on muscle development. smyd1a and smyd1b double mutants lead to dramatic reduction of myosin protein levels and complete disruption of sarcomere organization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.354;2.1.1.-;2.1.1.359;2.1.1.355;2.1.1.362;2.1.1.361", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031430 M band", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0007507 heart development;GO:0045892 negative regulation of DNA-templated transcription;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1PGA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PIL2-1", "uniprot_id": "A0A8M1PIL2_DANRE", "mass": 59313.0, "length": 540, "protein_name": "Formimidoyltransferase-cyclodeaminase", "gene_name": "ftcd", "organism": "Zebrafish", "refseq_name": "formimidoyltransferase-cyclodeaminase", "refseq_ac": "NP_957371", "gene_names_uniprotkb": "ftcd; wu:fp37b11; zgc:63647", "gene_names_refseq": "ftcd; wu:fp37b11; zgc:63647", "protein_names_uniprotkb": "Formimidoyltransferase-cyclodeaminase; 2.1.2.5; 4.3.1.4; Formiminotransferase-cyclodeaminase", "protein_names_refseq": "formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase", "tax_id": 7955, "disease": "glutamate formiminotransferase deficiency (Disease Ontology:DOID:0111679)", "pathway": " (dre:394052)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16109975;18678863;26469318;31546038;34941873", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF102927.1, EH487314.1, EH525514.1 and EH513708.1. On Feb 16, 2011 this sequence version replaced NP_957371.1., [RefSeq]; Binds and promotes bundling of vimentin filaments originating from the Golgi., [UniProtKB, UniProtKB]; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool., [UniProtKB, UniProtKB]; Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005542 folic acid binding;GO:0030409 glutamate formimidoyltransferase activity;GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005814 centriole", "go_biological_process": "GO:0036333 hepatocyte homeostasis;GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1PIL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1Q7N6-1", "uniprot_id": "A0A8M1Q7N6_DANRE", "mass": 51992.0, "length": 452, "protein_name": "Phosphatidate cytidylyltransferase", "gene_name": "cds1", "organism": "Zebrafish", "refseq_name": "phosphatidate cytidylyltransferase 1", "refseq_ac": "XP_001341899", "gene_names_uniprotkb": "cds1", "gene_names_refseq": "cds1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase; 2.7.7.41", "protein_names_refseq": "phosphatidate cytidylyltransferase 1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:100002015); (R-DRE-1483226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001341899.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IMQ7", "ec_number_list": "2.7.7.41", "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1Q7N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRN0-1", "uniprot_id": "A0A8M1RRN0_DANRE", "mass": 44633.0, "length": 388, "protein_name": "Fucosyltransferase", "gene_name": "si:ch1073-440p11.2", "organism": "Zebrafish", "refseq_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "refseq_ac": "XP_002665488", "gene_names_uniprotkb": "si:ch1073-440p11.2", "gene_names_refseq": "si:ch1073-440p11.2", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:100333886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.7.7.-", "go_molecular_function": "GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B201-1", "uniprot_id": "A0A8M2B201_DANRE", "mass": 69976.0, "length": 608, "protein_name": "Tyrosine-protein kinase", "gene_name": "syk", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase SYK isoform X1", "refseq_ac": "XP_005155595", "gene_names_uniprotkb": "syk", "gene_names_refseq": "syk", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase SYK isoform X1", "tax_id": 7955, "disease": "immunodeficiency 82 (Disease Ontology:DOID:0061053); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (dre:405769); (R-DRE-114604); (R-DRE-354192); (R-DRE-5621480); (R-DRE-912631); (R-DRE-9705462)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "20096681;23234507;25386660;26469318;32341750;33991914", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QFN4", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;3.6.5.2;2.7.1.137", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0035556 intracellular signal transduction;GO:0033630 positive regulation of cell adhesion mediated by integrin;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2D2-1", "uniprot_id": "A0A8M2B2D2_DANRE", "mass": 112208.0, "length": 1010, "protein_name": "Peptidyl-glycine alpha-amidating monooxygenase isoform X1", "gene_name": "pam", "organism": "Zebrafish", "refseq_name": "peptidyl-glycine alpha-amidating monooxygenase isoform X1", "refseq_ac": "XP_005155561", "gene_names_uniprotkb": "pam", "gene_names_refseq": "pam", "protein_names_uniprotkb": "Peptidyl-glycine alpha-amidating monooxygenase isoform X1", "protein_names_refseq": "peptidyl-glycine alpha-amidating monooxygenase isoform X1", "tax_id": 7955, "disease": "hypothyroidism (Disease Ontology:DOID:1459); prostate adenocarcinoma (Disease Ontology:DOID:2526)", "pathway": " (dre:570822)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004504 peptidylglycine monooxygenase activity;GO:0004598 peptidylamidoglycolate lyase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0030033 microvillus assembly;GO:0097711 ciliary basal body-plasma membrane docking;GO:0060271 cilium assembly;GO:0001519 peptide amidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2E6-1", "uniprot_id": "A0A8M2B2E6_DANRE", "mass": 69321.0, "length": 627, "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camk2g1", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1", "refseq_ac": "XP_005156418", "gene_names_uniprotkb": "camk2g1; camk2ga; zgc:109908", "gene_names_refseq": "camk2g1; camk2ga; zgc:109908", "protein_names_uniprotkb": "calcium/calmodulin-dependent protein kinase; 2.7.11.17", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); heart conduction disease (Disease Ontology:DOID:10273); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0043226 organelle;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection", "go_biological_process": "GO:0046777 protein autophosphorylation;GO:0060113 inner ear receptor cell differentiation;GO:0048793 pronephros development;GO:0003146 heart jogging;GO:0072114 pronephros morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2L3-1", "uniprot_id": "A0A8M2B2L3_DANRE", "mass": 46251.0, "length": 426, "protein_name": "Tumor necrosis factor receptor superfamily member 1B isoform X1", "gene_name": "tnfrsf1b", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor receptor superfamily member 1B isoform X1", "refseq_ac": "XP_005155971", "gene_names_uniprotkb": "tnfrsf1b; rank; tnfr2; zgc:163064", "gene_names_refseq": "rank; tnfr2; tnfrsf1b; zgc:163064", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 1B isoform X1", "protein_names_refseq": "tumor necrosis factor receptor superfamily member 1B isoform X1", "tax_id": 7955, "disease": "cryptogenic organizing pneumonia (Disease Ontology:DOID:0050157); lupus nephritis (Disease Ontology:DOID:0080162); polymyositis (Disease Ontology:DOID:0080745); Parkinsonism (Disease Ontology:DOID:0080855); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); tuberculosis (Disease Ontology:DOID:399); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); acne (Disease Ontology:DOID:6543); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:100037357)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18802111;22340501;22956347;24567948;24802997;35267311;35364135;35489565;35652047;37685971", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0006915 apoptotic process;GO:0009615 response to virus;GO:0001944 vasculature development;GO:1901534 positive regulation of hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B2L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B359-1", "uniprot_id": "A0A8M2B359_DANRE", "mass": 67026.0, "length": 600, "protein_name": "Estrogen receptor 2b isoform X1", "gene_name": "esr2b", "organism": "Zebrafish", "refseq_name": "estrogen receptor 2b isoform X1", "refseq_ac": "XP_005157029", "gene_names_uniprotkb": "esr2b; ER[b]1; abrrl6; zfER-beta1; zfER[b]1", "gene_names_refseq": "ER[b]1; abrrl6; esr2b; zfER-beta1; zfER[b]1", "protein_names_uniprotkb": "Estrogen receptor 2b isoform X1", "protein_names_refseq": "estrogen receptor 2b isoform X1", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); ovarian dysgenesis 8 (Disease Ontology:DOID:0080500); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myasthenia gravis (Disease Ontology:DOID:437); pulmonary hypertension (Disease Ontology:DOID:6432); adenoma (Disease Ontology:DOID:657); rheumatoid arthritis (Disease Ontology:DOID:7148); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-1257604); (R-DRE-383280); (R-DRE-6811558); (R-DRE-8939211); (R-DRE-9009391)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H092;A0AC58H097;B8JJL4", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0004879 nuclear receptor activity;GO:1990239 steroid hormone binding;GO:0030284 nuclear estrogen receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0007530 sex determination;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043627 response to estrogen;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3P5-1", "uniprot_id": "A0A8M2B3P5_DANRE", "mass": 80473.0, "length": 719, "protein_name": "dual-specificity kinase", "gene_name": "dyrk1ab", "organism": "Zebrafish", "refseq_name": "dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b", "refseq_ac": "NP_001334760", "gene_names_uniprotkb": "dyrk1ab; fi12h09; wu:fi12h09; wu:fi26g04", "gene_names_refseq": "dyrk1ab; fi12h09; wu:fi12h09; wu:fi26g04", "protein_names_uniprotkb": "dual-specificity kinase; 2.7.12.1", "protein_names_refseq": "dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b; dual-specificity tyrosine-regulated kinase 1ab", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 7 (Disease Ontology:DOID:0070037); intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (dre:327466)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "26469318;27189481;28252024;31043432;34090874;35165364;36417527;36933215", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007209.1, GFIL01009102.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1, EH506525.1 and CK024242.1. On Dec 15, 2016 this sequence version replaced XP_002664656.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HA52;A0AC58HA60;A0AC58HA64;X1WCB7", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2B3P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4F9-1", "uniprot_id": "A0A8M2B4F9_DANRE", "mass": 70493.0, "length": 630, "protein_name": "Melanoma cell adhesion molecule b isoform X1", "gene_name": "mcamb", "organism": "Zebrafish", "refseq_name": "melanoma cell adhesion molecule b isoform X1", "refseq_ac": "XP_005157627", "gene_names_uniprotkb": "mcamb; cd146; gicerin; id:ibd3512; mcam", "gene_names_refseq": "cd146; gicerin; id:ibd3512; mcamb; mcam", "protein_names_uniprotkb": "Melanoma cell adhesion molecule b isoform X1", "protein_names_refseq": "melanoma cell adhesion molecule b isoform X1", "tax_id": 7955, "disease": "malignant mesothelioma (Disease Ontology:DOID:1790); impotence (Disease Ontology:DOID:1875); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001568 blood vessel development;GO:0060271 cilium assembly;GO:0001946 lymphangiogenesis;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B4F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4T8-1", "uniprot_id": "A0A8M2B4T8_DANRE", "mass": 80875.0, "length": 747, "protein_name": "Aryl hydrocarbon receptor nuclear translocator isoform X1", "gene_name": "arnt", "organism": "Zebrafish", "refseq_name": "aryl hydrocarbon receptor nuclear translocator isoform e", "refseq_ac": "NP_001428910", "gene_names_uniprotkb": "arnt; zgc:136664", "gene_names_refseq": "arnt; hif1beta; zgc:136664", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator isoform X1", "protein_names_refseq": "ARNT1; aryl hydrocarbon receptor nuclear translocator isoform e", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); renal cell carcinoma (Disease Ontology:DOID:4450); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:493634)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16214955;16306231;16333842;16936225;19449054;33838494;34047769;37039097;37290634;38710459", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1177370.1, SRR26395039.945422.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jul 17, 2025 this sequence version replaced XP_005157909.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos., [RefSeq, PubMed]; Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity., [RefSeq, PubMed]; Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription., [UniProtKB, UniProtKB, UniProtKB]; ZfARNT1 proteins are required for ptotection against 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0009636 response to toxic substance;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B4T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5G5-1", "uniprot_id": "A0A8M2B5G5_DANRE", "mass": 63974.0, "length": 561, "protein_name": "Grainyhead-like protein 3 homolog isoform X1", "gene_name": "grhl3", "organism": "Zebrafish", "refseq_name": "grainyhead-like protein 3 homolog isoform X1", "refseq_ac": "XP_005158615", "gene_names_uniprotkb": "grhl3", "gene_names_refseq": "grhl3", "protein_names_uniprotkb": "Grainyhead-like protein 3 homolog isoform X1", "protein_names_refseq": "grainyhead-like protein 3 homolog isoform X1", "tax_id": 7955, "disease": "Van der Woude syndrome (Disease Ontology:DOID:0060239)", "pathway": " (dre:794613)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005158615.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0071466 cellular response to xenobiotic stimulus;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6R2-1", "uniprot_id": "A0A8M2B6R2_DANRE", "mass": 150097.0, "length": 1343, "protein_name": "lysophospholipase", "gene_name": "pnpla6", "organism": "Zebrafish", "refseq_name": "patatin-like phospholipase domain-containing protein 6 isoform X2", "refseq_ac": "XP_005160109", "gene_names_uniprotkb": "pnpla6", "gene_names_refseq": "pnpla6", "protein_names_uniprotkb": "lysophospholipase; 3.1.1.5", "protein_names_refseq": "patatin-like phospholipase domain-containing protein 6 isoform X2", "tax_id": 7955, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:560986)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.5;3.1.1.4;3.1.1.3", "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0016042 lipid catabolic process;GO:0030514 negative regulation of BMP signaling pathway;GO:0046470 phosphatidylcholine metabolic process;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AIT6-1", "uniprot_id": "A0A8M3AIT6_DANRE", "mass": 353143.0, "length": 3184, "protein_name": "Huntingtin", "gene_name": "htt", "organism": "Zebrafish", "refseq_name": "huntingtin isoform X1", "refseq_ac": "XP_009291239", "gene_names_uniprotkb": "htt; ZHD; hd", "gene_names_refseq": "ZHD; hd; htt", "protein_names_uniprotkb": "Huntingtin", "protein_names_refseq": "huntingtin isoform X1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role in microtubule-mediated transport or vesicle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0048589 developmental growth;GO:0021954 central nervous system neuron development;GO:0051216 cartilage development;GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AIT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B818-1", "uniprot_id": "NEC1A_DANRE", "mass": 55166.0, "length": 496, "protein_name": "Nectin 1a", "gene_name": "nectin1a", "organism": "Zebrafish", "refseq_name": "nectin 1a", "refseq_ac": "NP_001161042", "gene_names_uniprotkb": "nectin1a; pvrl1a", "gene_names_refseq": "nectin1a; pvrl1a", "protein_names_uniprotkb": "Nectin 1a", "protein_names_refseq": "nectin 1a; nectin-1a; poliovirus receptor-related 1a", "tax_id": 7955, "disease": "cleft lip-palate-ectodermal dysplasia syndrome (Disease Ontology:DOID:0060773); ectodermal dysplasia (Disease Ontology:DOID:2121); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:100136836)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19097185;23594743;27189481;28252024;33436952;36229674", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY881625.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY881625.2., [RefSeq]; Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results characterize two paralogous zebrafish nectin-1 genes, nectin-1a and nectin-1b, that differ in expression during development in eye and brain., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8A6;B0JYH7", "ec_number_list": "", "go_molecular_function": "GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:1903929 primary palate development;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B818-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8J1-1", "uniprot_id": "A0A8M2B8J1_DANRE", "mass": 48162.0, "length": 441, "protein_name": "Steroid hormone receptor ERR1 isoform X1", "gene_name": "esrra", "organism": "Zebrafish", "refseq_name": "steroid hormone receptor ERR1 isoform X1", "refseq_ac": "XP_005161401", "gene_names_uniprotkb": "esrra; err1; erralpha; erra; esrral", "gene_names_refseq": "err1; erralpha; erra; esrral; esrra", "protein_names_uniprotkb": "Steroid hormone receptor ERR1 isoform X1", "protein_names_refseq": "steroid hormone receptor ERR1 isoform X1", "tax_id": 7955, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042074 cell migration involved in gastrulation;GO:0061035 regulation of cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B989-1", "uniprot_id": "A0A8M2B989_DANRE", "mass": 136030.0, "length": 1206, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2", "gene_name": "pan2", "organism": "Zebrafish", "refseq_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1", "refseq_ac": "XP_005162402", "gene_names_uniprotkb": "pan2; PAN2", "gene_names_refseq": "pan2", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:792831)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B989-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B990-1", "uniprot_id": "A0A8M2B990_DANRE", "mass": 51447.0, "length": 466, "protein_name": "Transcription factor NF-E2 45 kDa subunit isoform X1", "gene_name": "nfe2", "organism": "Zebrafish", "refseq_name": "transcription factor NF-E2 45 kDa subunit isoform X1", "refseq_ac": "XP_073794110", "gene_names_uniprotkb": "nfe2", "gene_names_refseq": "nfe2", "protein_names_uniprotkb": "Transcription factor NF-E2 45 kDa subunit isoform X1", "protein_names_refseq": "transcription factor NF-E2 45 kDa subunit isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-983231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IIU2;F1QWY1", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0010725 regulation of primitive erythrocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9H5-1", "uniprot_id": "A0A8M2B9H5_DANRE", "mass": 64092.0, "length": 586, "protein_name": "Eyes absent homolog", "gene_name": "eya1", "organism": "Zebrafish", "refseq_name": "protein phosphatase EYA1 isoform X12", "refseq_ac": "XP_005162692", "gene_names_uniprotkb": "eya1; wu:fc13c10; zgc:100770", "gene_names_refseq": "eya1; wu:fc13c10; zgc:100770", "protein_names_uniprotkb": "Eyes absent homolog; 3.1.3.48", "protein_names_refseq": "protein phosphatase EYA1 isoform X12", "tax_id": 7955, "disease": "branchiootic syndrome 1 (Disease Ontology:DOID:0061209); branchiootorenal syndrome 1 (Disease Ontology:DOID:0111423); branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IPF2;A0AC58IPF3;A0AC58IPF9", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0042472 inner ear morphogenesis;GO:0048840 otolith development;GO:0042471 ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B9H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B8B0-1", "uniprot_id": "A0A8M3B8B0_DANRE", "mass": 121453.0, "length": 1141, "protein_name": "Granulin a isoform X1", "gene_name": "grna", "organism": "Zebrafish", "refseq_name": "granulin a isoform X1", "refseq_ac": "XP_009297752", "gene_names_uniprotkb": "grna; grn; sb:eu337; wu:fb11g12; wu:fj18f05", "gene_names_refseq": "grna; grn; sb:eu337; wu:fb11g12; wu:fj18f05", "protein_names_uniprotkb": "Granulin a isoform X1", "protein_names_refseq": "granulin a isoform X1", "tax_id": 7955, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); frontotemporal dementia 2 (Disease Ontology:DOID:0060672); neuronal ceroid lipofuscinosis 11 (Disease Ontology:DOID:0110732); Alzheimer's disease (Disease Ontology:DOID:10652); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (dre:791524)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;16277664;16869712;17984093;19263476;33480022;33560393;34681875;36424432;37897724", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009297752.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0001889 liver development;GO:0021522 spinal cord motor neuron differentiation;GO:0010842 retina layer formation;GO:0036269 swimming behavior;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3B8B0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBE5-1", "uniprot_id": "A0A8M2BBE5_DANRE", "mass": 33255.0, "length": 292, "protein_name": "TLC domain containing 3Ba", "gene_name": "tlcd3ba", "organism": "Zebrafish", "refseq_name": "TLC domain containing 3Ba", "refseq_ac": "NP_001417785", "gene_names_uniprotkb": "tlcd3ba; fam57ba; fb95d07; wu:fb95d07; zgc:73225", "gene_names_refseq": "fam57ba; fb95d07; tlcd3ba; wu:fb95d07; zgc:73225", "protein_names_uniprotkb": "TLC domain containing 3Ba", "protein_names_refseq": "TLC domain ceramide synthase 3Ba; TLC domain containing 3Ba; family with sequence similarity 57 member Ba", "tax_id": 7955, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cone-rod dystrophy 22 (Disease Ontology:DOID:0081448)", "pathway": " (dre:323326)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22566537;26469318;28934389", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588718.12964433.1, SRR32588722.46584430.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505382, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On May 31, 2024 this sequence version replaced XP_005163910.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IDQ8;A0AC58IDR5;A0AC58IDS1;A0AC58IDS9;A0AC58IDT0;A0AC58IDU0;A0AC58IDU2;A0AC58IDU4;A0AC58IDU6;A0AC58IDV1;A0AC58IDV6;A0AC58IDW0;A0AC58IDW6;A0AC58IDX3;A0AC58IDX7;A0AC58IDX8;A0AC58IDY1;F1QF55", "ec_number_list": "", "go_molecular_function": "GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0001964 startle response;GO:0046513 ceramide biosynthetic process;GO:0055088 lipid homeostasis;GO:0019216 regulation of lipid metabolic process;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BBE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBF6-1", "uniprot_id": "A0A8M2BBF6_DANRE", "mass": 114683.0, "length": 1041, "protein_name": "Lethal(2) giant larvae protein homolog 1 isoform X1", "gene_name": "llgl1", "organism": "Zebrafish", "refseq_name": "lethal(2) giant larvae protein homolog 1 isoform X1", "refseq_ac": "XP_005164198", "gene_names_uniprotkb": "llgl1; zgc:153337", "gene_names_refseq": "llgl1; zgc:153337", "protein_names_uniprotkb": "Lethal(2) giant larvae protein homolog 1 isoform X1", "protein_names_refseq": "lethal(2) giant larvae protein homolog 1 isoform X1", "tax_id": 7955, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0012505 endomembrane system;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0060887 limb epidermis development;GO:0003171 atrioventricular valve development;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0003407 neural retina development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCE3-1", "uniprot_id": "A0A8M2BCE3_DANRE", "mass": 109261.0, "length": 992, "protein_name": "AP complex subunit beta", "gene_name": "ap1b1", "organism": "Zebrafish", "refseq_name": "AP-1 complex subunit beta-1 isoform X1", "refseq_ac": "XP_005165223", "gene_names_uniprotkb": "ap1b1; fa11e04; si:ch211-149d1.1; wu:fa11e04", "gene_names_refseq": "ap1b1; fa11e04; si:ch211-149d1.1; wu:fa11e04", "protein_names_uniprotkb": "AP complex subunit beta", "protein_names_refseq": "AP-1 complex subunit beta-1 isoform X1", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:562166)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10526320;23593334;26469318;28252024;31053140;9491988", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0012505 endomembrane system;GO:0031410 cytoplasmic vesicle;GO:0030131 clathrin adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:2000649 regulation of sodium ion transmembrane transporter activity;GO:1903076 regulation of protein localization to plasma membrane;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BCE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCU2-1", "uniprot_id": "A0A8M2BCU2_DANRE", "mass": 76203.0, "length": 690, "protein_name": "T-box transcription factor TBX2a isoform X1", "gene_name": "tbx2a", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX2a isoform X1", "refseq_ac": "XP_005165613", "gene_names_uniprotkb": "tbx2a; tbx-a; tbx2l; tbxa; zgc:85705", "gene_names_refseq": "tbx-a; tbx2a; tbx2l; tbxa; zgc:85705", "protein_names_uniprotkb": "T-box transcription factor TBX2a isoform X1", "protein_names_refseq": "T-box transcription factor TBX2a isoform X1", "tax_id": 7955, "disease": "vertebral anomalies and variable endocrine and T-cell dysfunction (Disease Ontology:DOID:0070345); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); heart septal defect (Disease Ontology:DOID:1681); atrial heart septal defect (Disease Ontology:DOID:1882)", "pathway": " (dre:573084)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10331981;12093383;17460765;18815807;21448936;34358225;34462505;34767486;36551976;36745553", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0048484 enteric nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BCU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BD22-1", "uniprot_id": "A0A8M2BD22_DANRE", "mass": 159836.0, "length": 1438, "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "erbb3a", "organism": "Zebrafish", "refseq_name": "receptor tyrosine-protein kinase erbB-3a isoform X1", "refseq_ac": "XP_005165758", "gene_names_uniprotkb": "erbb3a; ERBB; erbb3; im:7148890; si:dz150i12.1; v-erb-b", "gene_names_refseq": "ERBB; erbb3a; erbb3; im:7148890; si:dz150i12.1; v-erb-b", "protein_names_uniprotkb": "Receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "receptor tyrosine-protein kinase erbB-3a isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); lethal congenital contracture syndrome 2 (Disease Ontology:DOID:0060560); neuronal intestinal dysplasia type A (Disease Ontology:DOID:0080679); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517); median neuropathy (Disease Ontology:DOID:571); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:386635)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15797019;15886089;16109975;18508863;19133254;26469318;27846271;33330499;34732706;38944125", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0038131 neuregulin receptor activity;GO:0038132 neuregulin binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0009966 regulation of signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BD22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDJ7-1", "uniprot_id": "A0A8M2BDJ7_DANRE", "mass": 149947.0, "length": 1356, "protein_name": "Macrophage-stimulating protein receptor", "gene_name": "mst1ra", "organism": "Zebrafish", "refseq_name": "macrophage-stimulating protein receptor isoform X1", "refseq_ac": "XP_005166175", "gene_names_uniprotkb": "mst1ra", "gene_names_refseq": "mst1ra", "protein_names_uniprotkb": "Macrophage-stimulating protein receptor; 2.7.10.1; p185-Ron", "protein_names_refseq": "macrophage-stimulating protein receptor isoform X1", "tax_id": 7955, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:100002448)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JVJ6;A0AC58JVM2;A0AC58JVN8", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0012505 endomembrane system;GO:0016020 membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0045087 innate immune response;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE48-1", "uniprot_id": "A0A8M2BE48_DANRE", "mass": 58512.0, "length": 519, "protein_name": "Dual specificity protein phosphatase CDC14B isoform X1", "gene_name": "cdc14b", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase CDC14B isoform X1", "refseq_ac": "XP_005166727", "gene_names_uniprotkb": "cdc14b; cdc14a; zgc:55844", "gene_names_refseq": "cdc14a; cdc14b; zgc:55844", "protein_names_uniprotkb": "Dual specificity protein phosphatase CDC14B isoform X1", "protein_names_refseq": "dual specificity protein phosphatase CDC14B isoform X1", "tax_id": 7955, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:393148)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17719025;21177342;23027426;26469318;27189481;30061596;35929537;37867960", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005819 spindle;GO:0000793 condensed chromosome", "go_biological_process": "GO:0051301 cell division;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0000226 microtubule cytoskeleton organization;GO:0007096 regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2BE48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE61-1", "uniprot_id": "A0A8M2BE61_DANRE", "mass": 74212.0, "length": 676, "protein_name": "Basic helix-loop-helix ARNT like 1b isoform X1", "gene_name": "bmal1b", "organism": "Zebrafish", "refseq_name": "basic helix-loop-helix ARNT like 1b isoform X1", "refseq_ac": "XP_005166673", "gene_names_uniprotkb": "bmal1b; arntl1b; zfBMAL3", "gene_names_refseq": "arntl1b; bmal1b; zfBMAL3", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT like 1b isoform X1", "protein_names_refseq": "basic helix-loop-helix ARNT like 1b isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cholestasis (Disease Ontology:DOID:13580); bipolar disorder (Disease Ontology:DOID:3312); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BE61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEB6-1", "uniprot_id": "A0A8M2BEB6_DANRE", "mass": 84997.0, "length": 747, "protein_name": "Kinesin-like protein", "gene_name": "kif2a", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF2A isoform X1", "refseq_ac": "XP_005166887", "gene_names_uniprotkb": "kif2a; fj55b02; wu:fj55b02; zgc:103670", "gene_names_refseq": "fj55b02; kif2a; wu:fj55b02; zgc:103670", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF2A isoform X1", "tax_id": 7955, "disease": "complex cortical dysplasia with other brain malformations 3 (Disease Ontology:DOID:0090134)", "pathway": " (dre:447926)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;25993117;26469318;27189481;28252024;34404749", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0046959 habituation;GO:0051301 cell division;GO:0019226 transmission of nerve impulse;GO:0007018 microtubule-based movement;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BEB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEP6-1", "uniprot_id": "A0A8M2BEP6_DANRE", "mass": 67231.0, "length": 584, "protein_name": "G protein-coupled receptor kinase", "gene_name": "grk5l", "organism": "Zebrafish", "refseq_name": "G protein-coupled receptor kinase 5 isoform X1", "refseq_ac": "XP_005167309", "gene_names_uniprotkb": "grk5l", "gene_names_refseq": "grk5l", "protein_names_uniprotkb": "G protein-coupled receptor kinase; 2.7.11.-", "protein_names_refseq": "G protein-coupled receptor kinase 5 isoform X1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:567452)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0032007 negative regulation of TOR signaling;GO:0009966 regulation of signal transduction;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFK1-1", "uniprot_id": "A0A8M2BFK1_DANRE", "mass": 47556.0, "length": 405, "protein_name": "Fucosyltransferase", "gene_name": "ft2", "organism": "Zebrafish", "refseq_name": "alpha(1,3)fucosyltransferase gene 2 isoform X1", "refseq_ac": "XP_005168265", "gene_names_uniprotkb": "ft2; zFT2; zgc:194457", "gene_names_refseq": "ft2; zFT2; zgc:194457", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "alpha(1,3)fucosyltransferase gene 2 isoform X1", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.7.7.-", "go_molecular_function": "GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BG36-1", "uniprot_id": "A0A8M2BG36_DANRE", "mass": 79194.0, "length": 721, "protein_name": "RNA helicase", "gene_name": "ddx3xb", "organism": "Zebrafish", "refseq_name": "DEAD-box helicase 3 X-linked b isoform X1", "refseq_ac": "XP_005168845", "gene_names_uniprotkb": "ddx3xb; ddx3b; etID309900.24; p110a; p110; pl10a; pl10; wu:fb43h11; wu:fy72b06", "gene_names_refseq": "ddx3b; ddx3xb; etID309900.24; p110a; p110; pl10a; pl10; wu:fb43h11; wu:fy72b06", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "DEAD-box helicase 3 X-linked b isoform X1", "tax_id": 7955, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); childhood medulloblastoma (Disease Ontology:DOID:3869); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168845.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043186 P granule", "go_biological_process": "GO:0007420 brain development;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BG36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BG42-1", "uniprot_id": "A0A8M2BG42_DANRE", "mass": 148628.0, "length": 1356, "protein_name": "[histone H3]-trimethyl-L-lysine(27) demethylase", "gene_name": "kdm6al", "organism": "Zebrafish", "refseq_name": "lysine (K)-specific demethylase 6A, like isoform 1", "refseq_ac": "NP_001428613", "gene_names_uniprotkb": "kdm6al; utxl1; uty; zgc:158313", "gene_names_refseq": "kdm6al; utxl1; uty; zgc:158313", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(27) demethylase; 1.14.11.68", "protein_names_refseq": "lysine (K)-specific demethylase 6A, like isoform 1; ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1; utx1", "tax_id": 7955, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); Kabuki syndrome (Disease Ontology:DOID:0060473); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); bladder urothelial carcinoma (Disease Ontology:DOID:4006); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17851529", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01013917.1, SRR26395050.911022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 26, 2025 this sequence version replaced XP_005168853.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Findings identify utx1 with important roles in H3K27 methylation regulation and in animal anterior-posterior development [utx1], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.68", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0071558 histone H3K27me2/H3K27me3 demethylase activity", "go_cellular_component": "GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0007507 heart development;GO:0007420 brain development;GO:0009952 anterior/posterior pattern specification;GO:0010468 regulation of gene expression;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BG42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGN5-1", "uniprot_id": "A0A8M2BGN5_DANRE", "mass": 93336.0, "length": 807, "protein_name": "Angiotensin-converting enzyme", "gene_name": "ace2", "organism": "Zebrafish", "refseq_name": "angiotensin-converting enzyme 2 isoform 2 precursor", "refseq_ac": "NP_001429079", "gene_names_uniprotkb": "ace2; zgc:92514", "gene_names_refseq": "ace2; zgc:92514", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 3.4.-.-", "protein_names_refseq": "angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2 isoform 2 precursor", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cerebral malaria (Disease Ontology:DOID:14069); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); avian influenza (Disease Ontology:DOID:4492); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (R-DRE-2022377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.3611908.1, SRR26395017.1309291.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jul 28, 2025 this sequence version replaced XP_005169417.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.-.-", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0008241 peptidyl-dipeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0002003 angiotensin maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI19-1", "uniprot_id": "A0A8M2BI19_DANRE", "mass": 65321.0, "length": 588, "protein_name": "Transcription factor p65 isoform X1", "gene_name": "rela", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rela; nfkb3; p65", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor p65 isoform X1", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lymphoma (Disease Ontology:DOID:0060058); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); mastoiditis (Disease Ontology:DOID:0060322); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); bacterial infectious disease (Disease Ontology:DOID:104); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); steatotic liver disease (Disease Ontology:DOID:9452); encephalitis (Disease Ontology:DOID:9588); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58FYM6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007399 nervous system development;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJY3-1", "uniprot_id": "ABRX2_DANRE", "mass": 46120.0, "length": 416, "protein_name": "BRISC complex subunit abraxas 2", "gene_name": "abraxas2", "organism": "Zebrafish", "refseq_name": "BRISC complex subunit Abraxas 2", "refseq_ac": "NP_998460", "gene_names_uniprotkb": "abraxas2; abraxas2b; fam175b; wu:fi33f11; zgc:85800", "gene_names_refseq": "abraxas2b; abraxas2; fam175b; wu:fi33f11; zgc:85800", "protein_names_uniprotkb": "BRISC complex subunit abraxas 2", "protein_names_refseq": "BRISC complex subunit Abraxas 2; abraxas 2b, BRISC complex subunit; family with sequence similarity 175, member B", "tax_id": 7955, "disease": "", "pathway": " (dre:406584); (R-DRE-5689901)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12477932;23594743;26344097", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067636.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067636.1., [RefSeq]; Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (By similarity). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AUE4;Q6NWD2", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0090307 mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AJY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ALU6-1", "uniprot_id": "A0A8M3ALU6_DANRE", "mass": 53082.0, "length": 470, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "gabra1", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-1 isoform X1", "refseq_ac": "XP_009293960", "gene_names_uniprotkb": "gabra1; zgc:153566", "gene_names_refseq": "gabra1; zgc:153566", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit alpha-1 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 19 (Disease Ontology:DOID:0080431); hepatic encephalopathy (Disease Ontology:DOID:13413); generalized epilepsy (Disease Ontology:DOID:1827); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0070208 protein heterotrimerization;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ALU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AMT1-1", "uniprot_id": "A0A8M3AMT1_DANRE", "mass": 46958.0, "length": 416, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "b4galt3", "organism": "Zebrafish", "refseq_name": "beta-1,4-galactosyltransferase 3 isoform X1", "refseq_ac": "XP_009295048", "gene_names_uniprotkb": "b4galt3", "gene_names_refseq": "b4galt3", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "beta-1,4-galactosyltransferase 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:561756)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.90", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0006682 galactosylceramide biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AMT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANT7-1", "uniprot_id": "A0A8M3ANT7_DANRE", "mass": 63984.0, "length": 585, "protein_name": "Vesicular glutamate transporter 1", "gene_name": "slc17a7b", "organism": "Zebrafish", "refseq_name": "vesicular glutamate transporter 1", "refseq_ac": "XP_009295917", "gene_names_uniprotkb": "slc17a7b", "gene_names_refseq": "slc17a7b", "protein_names_uniprotkb": "Vesicular glutamate transporter 1; Solute carrier family 17 member 7", "protein_names_refseq": "vesicular glutamate transporter 1", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dre:100331980)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009295917.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015293 symporter activity;GO:0015297 antiporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex;GO:0060076 excitatory synapse", "go_biological_process": "GO:0050803 regulation of synapse structure or activity;GO:0007600 sensory perception;GO:0035249 synaptic transmission, glutamatergic;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQU5-1", "uniprot_id": "A0A8M3AQU5_DANRE", "mass": 287599.0, "length": 2646, "protein_name": "histone acetyltransferase", "gene_name": "ep300b", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase p300 isoform X1", "refseq_ac": "XP_009297682", "gene_names_uniprotkb": "ep300b", "gene_names_refseq": "ep300b", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "histone acetyltransferase p300 isoform X1", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cardiomyopathy (Disease Ontology:DOID:0050700); cardiac arrest (Disease Ontology:DOID:0060319); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:565612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0140297 DNA-binding transcription factor binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AQU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ARH7-1", "uniprot_id": "A0A8M3ARH7_DANRE", "mass": 571836.0, "length": 5243, "protein_name": "Usherin", "gene_name": "ush2a", "organism": "Zebrafish", "refseq_name": "usherin", "refseq_ac": "XP_073784725", "gene_names_uniprotkb": "ush2a", "gene_names_refseq": "ush2a", "protein_names_uniprotkb": "Usherin", "protein_names_refseq": "usherin", "tax_id": 7955, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); nonsyndromic deafness (Disease Ontology:DOID:0050563); retinitis pigmentosa 39 (Disease Ontology:DOID:0110360); Usher syndrome type 2 (Disease Ontology:DOID:0110827); Usher syndrome type 2A (Disease Ontology:DOID:0110838); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:568982)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HS00", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane;GO:0042995 cell projection", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0007601 visual perception;GO:0007603 phototransduction, visible light;GO:0045494 photoreceptor cell maintenance;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ARH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ARK0-1", "uniprot_id": "A0A8M3ARK0_DANRE", "mass": 339373.0, "length": 3045, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 1", "gene_name": "celsr1a", "organism": "Zebrafish", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 1 isoform X1", "refseq_ac": "XP_009298735", "gene_names_uniprotkb": "celsr1a", "gene_names_refseq": "celsr1a", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 1", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 1 isoform X1", "tax_id": 7955, "disease": "yellow nail syndrome (Disease Ontology:DOID:0050468); hereditary lymphedema (Disease Ontology:DOID:0050580)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009298735.1. COMPLETENESS: full length., [RefSeq]; Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0007507 heart development;GO:0001894 tissue homeostasis;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ARK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ASR9-1", "uniprot_id": "A0A8M3ASR9_DANRE", "mass": 95610.0, "length": 827, "protein_name": "Tyrosine-protein kinase", "gene_name": "fer", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase Fer isoform X1", "refseq_ac": "XP_073807604", "gene_names_uniprotkb": "fer", "gene_names_refseq": "fer", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Fer isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565199); (R-DRE-1433557)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JMA0;F1QBS0", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0042995 cell projection", "go_biological_process": "GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0001568 blood vessel development;GO:0038095 Fc-epsilon receptor signaling pathway;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ASR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AT57-1", "uniprot_id": "A0A8M3AT57_DANRE", "mass": 64882.0, "length": 578, "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "map3k7", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 7 isoform X1", "refseq_ac": "XP_009292938", "gene_names_uniprotkb": "map3k7; TAK1b; si:ch211-225h9.1; zgc:110612", "gene_names_refseq": "TAK1b; map3k7; si:ch211-225h9.1; zgc:110612", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 7; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 7 isoform X1", "tax_id": 7955, "disease": "frontometaphyseal dysplasia (Disease Ontology:DOID:0111785); frontometaphyseal dysplasia 2 (Disease Ontology:DOID:0111787); prostate cancer (Disease Ontology:DOID:10283); benign hypertensive renal disease (Disease Ontology:DOID:11520); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dre:553788); (R-DRE-168638); (R-DRE-4086398); (R-DRE-445989); (R-DRE-450302); (R-DRE-450321); (R-DRE-9020702); (R-DRE-937042); (R-DRE-975163)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "16556914;18039395;24069208;25028512;26469318;26992035;28642593", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IVJ5", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.10;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;2.3.2.27", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0009893 positive regulation of metabolic process;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M3AT57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AXB8-1", "uniprot_id": "A0A8M3AXB8_DANRE", "mass": 49978.0, "length": 460, "protein_name": "Endothelial transcription factor GATA-2a isoform X1", "gene_name": "gata2a", "organism": "Zebrafish", "refseq_name": "endothelial transcription factor GATA-2a isoform X1", "refseq_ac": "XP_009304056", "gene_names_uniprotkb": "gata2a; gata2; zg2", "gene_names_refseq": "gata2a; gata2; zg2", "protein_names_uniprotkb": "Endothelial transcription factor GATA-2a isoform X1", "protein_names_refseq": "endothelial transcription factor GATA-2a isoform X1", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 21 (Disease Ontology:DOID:0111947); pre-eclampsia (Disease Ontology:DOID:10591); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:30480); (R-DRE-8939236); (R-DRE-983231)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R9YJP8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045766 positive regulation of angiogenesis;GO:0035912 dorsal aorta morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BE71-1", "uniprot_id": "A0A8M3BE71_DANRE", "mass": 290865.0, "length": 2682, "protein_name": "histone acetyltransferase", "gene_name": "ep300a", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase p300 isoform X1", "refseq_ac": "XP_009304968", "gene_names_uniprotkb": "ep300a", "gene_names_refseq": "ep300a", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "histone acetyltransferase p300 isoform X1", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cardiomyopathy (Disease Ontology:DOID:0050700); cardiac arrest (Disease Ontology:DOID:0060319); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:559273)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304968.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0140297 DNA-binding transcription factor binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BE71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BCH5-1", "uniprot_id": "A0A8M3BCH5_DANRE", "mass": 238813.0, "length": 2117, "protein_name": "1-phosphatidylinositol 3-phosphate 5-kinase", "gene_name": "pikfyve", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 3-phosphate 5-kinase isoform X1", "refseq_ac": "XP_009302997", "gene_names_uniprotkb": "pikfyve; pip5k3; wu:fo93c03", "gene_names_refseq": "pikfyve; pip5k3; wu:fo93c03", "protein_names_uniprotkb": "1-phosphatidylinositol 3-phosphate 5-kinase; 2.7.1.150; 2.7.11.1; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; Serine-protein kinase PIKFYVE", "protein_names_refseq": "1-phosphatidylinositol 3-phosphate 5-kinase isoform X1", "tax_id": 7955, "disease": "Fleck corneal dystrophy (Disease Ontology:DOID:0060448); cataract (Disease Ontology:DOID:83); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0052810 1-phosphatidylinositol-5-kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032438 melanosome organization;GO:1903426 regulation of reactive oxygen species biosynthetic process;GO:0007041 lysosomal transport;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YUA3-1", "uniprot_id": "A0A8M6YUA3_DANRE", "mass": 159670.0, "length": 1450, "protein_name": "RecQ-like DNA helicase BLM", "gene_name": "blm", "organism": "Zebrafish", "refseq_name": "recQ-like DNA helicase BLM isoform X1", "refseq_ac": "XP_017207538", "gene_names_uniprotkb": "blm", "gene_names_refseq": "blm", "protein_names_uniprotkb": "RecQ-like DNA helicase BLM; 5.6.2.4; DNA 3'-5' helicase BLM", "protein_names_refseq": "recQ-like DNA helicase BLM isoform X1", "tax_id": 7955, "disease": "Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (dre:572540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0009378 four-way junction helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0007281 germ cell development;GO:0000724 double-strand break repair via homologous recombination;GO:0045950 negative regulation of mitotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YUA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YV86-1", "uniprot_id": "A0A8M6YV86_DANRE", "mass": 46321.0, "length": 420, "protein_name": "Pre-B-cell leukemia transcription factor 2 isoform X1", "gene_name": "pbx2", "organism": "Zebrafish", "refseq_name": "pre-B-cell leukemia transcription factor 2 isoform X1", "refseq_ac": "XP_017206849", "gene_names_uniprotkb": "pbx2; pbxy; wu:fb73g03", "gene_names_refseq": "pbx2; pbxy; wu:fb73g03", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 2 isoform X1", "protein_names_refseq": "pre-B-cell leukemia transcription factor 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YZQ0-1", "uniprot_id": "A0A8M6YZQ0_DANRE", "mass": 67707.0, "length": 619, "protein_name": "Glutathione hydrolase", "gene_name": "ggt1a", "organism": "Zebrafish", "refseq_name": "gamma-glutamyltransferase 1a isoform X1", "refseq_ac": "XP_017212782", "gene_names_uniprotkb": "ggt1a; ggt1; zgc:64172", "gene_names_refseq": "ggt1a; ggt1; zgc:64172", "protein_names_uniprotkb": "Glutathione hydrolase; 2.3.2.2; 3.4.19.13; Gamma-glutamyltransferase; Gamma-glutamyltranspeptidase", "protein_names_refseq": "gamma-glutamyltransferase 1a isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.2;3.4.19.13", "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0002682 regulation of immune system process;GO:0050727 regulation of inflammatory response;GO:0031179 peptide modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z9L8-1", "uniprot_id": "A0A8M6Z9L8_DANRE", "mass": 100537.0, "length": 898, "protein_name": "Glutamate receptor", "gene_name": "gria4a", "organism": "Zebrafish", "refseq_name": "glutamate receptor 4a isoform X1", "refseq_ac": "XP_017214716", "gene_names_uniprotkb": "gria4a; glur4a; gria4; iGluR4", "gene_names_refseq": "glur4a; gria4a; gria4; iGluR4", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor 4a isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0004970 glutamate-gated receptor activity", "go_cellular_component": "GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:0008347 glial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P2G9-1", "uniprot_id": "A0A8M9P2G9_DANRE", "mass": 83026.0, "length": 750, "protein_name": "Ankyrin repeat domain-containing protein 6b isoform X1", "gene_name": "ankrd6b", "organism": "Zebrafish", "refseq_name": "ankyrin repeat domain-containing protein 6b isoform X1", "refseq_ac": "XP_021324047", "gene_names_uniprotkb": "ankrd6b; ankrd6; diversin; si:dkey-181i3none", "gene_names_refseq": "ankrd6b; ankrd6; diversin; si:dkey-181i3none", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 6b isoform X1", "protein_names_refseq": "ankyrin repeat domain-containing protein 6b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:378477)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12183362;15371335;15647854;17032765;18971206;19335895;21215262;22318632;26257172;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324047.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0007507 heart development;GO:0046330 positive regulation of JNK cascade;GO:0030111 regulation of Wnt signaling pathway;GO:0001702 gastrulation with mouth forming second;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9P2G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P9M3-1", "uniprot_id": "A0A8M9P9M3_DANRE", "mass": 34907.0, "length": 308, "protein_name": "Receptor expression-enhancing protein", "gene_name": "reep1", "organism": "Zebrafish", "refseq_name": "receptor expression-enhancing protein 1 isoform X1", "refseq_ac": "XP_021323143", "gene_names_uniprotkb": "reep1", "gene_names_refseq": "reep1", "protein_names_uniprotkb": "Receptor expression-enhancing protein", "protein_names_refseq": "receptor expression-enhancing protein 1 isoform X1", "tax_id": 7955, "disease": "autosomal recessive distal hereditary motor neuronopathy 6 (Disease Ontology:DOID:0081425); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782); autosomal dominant distal hereditary motor neuronopathy 12 (Disease Ontology:DOID:0111205)", "pathway": " (dre:799901)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0050881 musculoskeletal movement;GO:0034599 cellular response to oxidative stress;GO:0036269 swimming behavior;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P9M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PCJ8-1", "uniprot_id": "A0A8M9PCJ8_DANRE", "mass": 46817.0, "length": 412, "protein_name": "P2X purinoceptor", "gene_name": "p2rx3b", "organism": "Zebrafish", "refseq_name": "P2X purinoceptor 3b", "refseq_ac": "NP_945337", "gene_names_uniprotkb": "p2rx3b; p2xr3.2; zP2X3.2; zgc:110486", "gene_names_refseq": "p2rx3b; p2xr3.2; zP2X3.2; zgc:110486", "protein_names_uniprotkb": "P2X purinoceptor; P2X purinoceptor 3", "protein_names_refseq": "P2X purinoceptor 3b", "tax_id": 7955, "disease": "", "pathway": " (dre:387300); (R-DRE-139853); (R-DRE-418346)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14580944;16413125;17868657;18755773;19356698;30631305;30894803;31076454;36484145;36648063", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029294.1, SRR32588723.2250600.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Feb 20, 2016 this sequence version replaced XP_009291561.1, NP_945337.2. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments, RNA-seq data and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Extracellular ATP-activated non-selective cation channel. Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization., [UniProtKB, UniProtKB]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B8A5B9", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PCJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PGT9-1", "uniprot_id": "A0A8M9PGT9_DANRE", "mass": 60836.0, "length": 532, "protein_name": "Beta-hexosaminidase", "gene_name": "hexa", "organism": "Zebrafish", "refseq_name": "beta-hexosaminidase subunit alpha isoform X1", "refseq_ac": "XP_021326163", "gene_names_uniprotkb": "hexa; zgc:112084", "gene_names_refseq": "hexa; zgc:112084", "protein_names_uniprotkb": "Beta-hexosaminidase; 3.2.1.52", "protein_names_refseq": "beta-hexosaminidase subunit alpha isoform X1", "tax_id": 7955, "disease": "Tay-Sachs disease (Disease Ontology:DOID:3320)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.52", "go_molecular_function": "GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:1901135 carbohydrate derivative metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PGT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PJN6-1", "uniprot_id": "A0A8M9PJN6_DANRE", "mass": 60190.0, "length": 530, "protein_name": "Serine/threonine-protein kinase receptor", "gene_name": "bmpr1ba", "organism": "Zebrafish", "refseq_name": "bone morphogenetic protein receptor type-1B precursor", "refseq_ac": "NP_571532", "gene_names_uniprotkb": "bmpr1ba; BMPR-IB; BR1b; alk6tr; bmpr1b; zALK-6; zgc:92220", "gene_names_refseq": "BMPR-IB; BR1b; alk6tr; bmpr1ba; bmpr1b; zALK-6; zgc:92220", "protein_names_uniprotkb": "Serine/threonine-protein kinase receptor; 2.7.11.30", "protein_names_refseq": "alk6; bone morphogenetic protein receptor type-1B precursor; bone morphogenetic protein receptor, type 1ba; bone morphogenetic protein receptor, type 1b", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); acromesomelic dysplasia 3 (Disease Ontology:DOID:0081237); brachydactyly type A2 (Disease Ontology:DOID:0110965); brachydactyly type A1D (Disease Ontology:DOID:0110978); osteochondrodysplasia (Disease Ontology:DOID:2256); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:30742)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;19377468;20151472;21266411;22899520;33925390;35034853;35646941;36372285;37329499", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081625.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081625.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0005025 transforming growth factor beta receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0048263 determination of dorsal identity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PJN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWK8-1", "uniprot_id": "OTOP1_DANRE", "mass": 65721.0, "length": 586, "protein_name": "Proton channel OTOP1", "gene_name": "otop1", "organism": "Zebrafish", "refseq_name": "proton channel OTOP1", "refseq_ac": "NP_942098", "gene_names_uniprotkb": "otop1; wu:fb76b02; zgc:103626", "gene_names_refseq": "otop1; wu:fb76b02; zgc:103626", "protein_names_uniprotkb": "Proton channel OTOP1; Otopetrin-1", "protein_names_refseq": "10 transmembrane domains; backstroke; bks; membrane associated; proton channel OTOP1", "tax_id": 7955, "disease": "", "pathway": " (dre:322893)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12651873;15480759;15581873;31160780;37798269;9007244", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY170648.1, BC083445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY170648.1. On Jul 6, 2005 this sequence version replaced XP_693112.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Otopetrin 1 in zebrafish may be involved in the protein trafficking of components required for formation of biominerals in the ear., [RefSeq, PubMed]; Proton-selective ion channel (PubMed:31160780). Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively (By similarity). May be involved in acid and base perception (By similarity). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel (PubMed:37798269). Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration (PubMed:15480759, PubMed:15581873)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Results demonstrate that otopetrin 1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2GQA4;Q5MKL8;Q5XJ61", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005902 microvillus", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0060336 negative regulation of type II interferon-mediated signaling pathway;GO:0032475 otolith formation;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZWK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08CE7-1", "uniprot_id": "CX7A1_DANRE", "mass": 9128.0, "length": 81, "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "cox7a1", "organism": "Zebrafish", "refseq_name": "cytochrome c oxidase subunit 7A1, mitochondrial", "refseq_ac": "NP_001166149", "gene_names_uniprotkb": "cox7a1; zgc:153177", "gene_names_refseq": "cox7a1; zgc:153177", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A1, mitochondrial", "protein_names_refseq": "cytochrome c oxidase subunit 7A1, mitochondrial; cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (dre:767664); (R-DRE-5628897); (R-DRE-611105); (R-DRE-9707564); (R-DRE-9864848)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "23594743;38701784", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH503330.1, EH531135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On May 20, 2010 this sequence version replaced XP_693548.1., [RefSeq]; Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:38701784). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (PubMed:38701784)., [UniProtKB, PubMed, UniProtKB]; Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NVX5", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0002082 regulation of oxidative phosphorylation;GO:0006119 oxidative phosphorylation;GO:0008535 respiratory chain complex IV assembly;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08CE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DC02-1", "uniprot_id": "KCD15_DANRE", "mass": 29310.0, "length": 257, "protein_name": "BTB/POZ domain-containing protein kctd15", "gene_name": "kctd15", "organism": "Zebrafish", "refseq_name": "BTB/POZ domain-containing protein kctd15", "refseq_ac": "NP_001003527", "gene_names_uniprotkb": "kctd15; zgc:100865", "gene_names_refseq": "kctd15b; kctd15; zgc:100865", "protein_names_uniprotkb": "BTB/POZ domain-containing protein kctd15; Potassium channel tetramerization domain-containing protein 15", "protein_names_refseq": "BTB/POZ domain-containing protein kctd15; novel potassium channel tetramerisation domain protein; potassium channel tetramerisation domain containing 15b; potassium channel tetramerisation domain containing 15; potassium channel tetramerization domain-containing protein 15", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "20685732;23382213;24086424;29216270;33028614", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078294.1, GDQQ01024641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078294.1. On Jul 6, 2005 this sequence version replaced XP_701426.1., [RefSeq]; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain., [UniProtKB, PubMed]; Kctd15 mutants show deficits in the development of both neural crest derivatives, and specific regions within the central nervous system, leading to a strong reduction in normal growth rates. Publication Status: Online-Only, [RefSeq, PubMed]; Kctd15 regulates nephron segment development by repressing Tfap2a activity. Publication Status: Online-Only, [RefSeq, PubMed]; Suppression of neural crest induction by inhibition of Wnt8.1 was rescued by reduction of Kctd15 expression, linking Kctd15 action to the Wnt pathway., [RefSeq, PubMed]; These data suggest that the non-SUMOylated form of Kctd15 functions in neural crest development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development;GO:0014033 neural crest cell differentiation;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6DC02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1YB07-1", "uniprot_id": "AML2A_DANRE", "mass": 81711.0, "length": 721, "protein_name": "Angiomotin-like 2a", "gene_name": "amotl2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "amotl2a; amotl2; cb308; sb:cb308; wu:fc41b07; wu:fc64c06", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiomotin-like 2a", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:558920); (R-DRE-2028269)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17293535;21937427;22362771;23594743;24806444;28842668", "class_list": "", "function": "Required for proper architecture of actin filaments and for cell movements during embryogenesis (PubMed:17293535). Plays a role in the radial actin fiber architecture in skin epithelial cells, thereby maintains cell geometry, size and cell interconnectivity within the skin (PubMed:28842668). Plays an important role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology and maintenance of dorsal aorta lumen expansion during embryogenesis (PubMed:24806444). May further play a role in the polarity, proliferation and migration of endothelial cells, and therefore participates in angiogenesis (PubMed:21937427). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus (PubMed:22362771). Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites (PubMed:17293535). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:21937427)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DIZ1;F1QMD1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0005938 cell cortex;GO:0030054 cell junction", "go_biological_process": "GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1YB07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U3V9-1", "uniprot_id": "SNF8_DANRE", "mass": 28850.0, "length": 258, "protein_name": "Vacuolar-sorting protein SNF8", "gene_name": "snf8", "organism": "Zebrafish", "refseq_name": "vacuolar-sorting protein SNF8", "refseq_ac": "NP_001007413", "gene_names_uniprotkb": "snf8; si:dkey-220f10.1; zgc:101578", "gene_names_refseq": "snf8; zgc:101578", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF8; ESCRT-II complex subunit VPS22", "protein_names_refseq": "ESCRT-II complex subunit VPS22; SNF8, ESCRT-II complex subunit, homolog; vacuolar sorting snf8 ELL associated of 30kDa; vacuolar-sorting protein SNF8", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:492771); (R-DRE-917729)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17490614;23594743;38423010", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085373.1, EG583539.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085373.1. On Dec 11, 2010 this sequence version replaced XP_001334064.1., [RefSeq]; Bi-allelic variants in SNF8 cause a disease spectrum ranging from severe developmental and epileptic encephalopathy to syndromic optic atrophy., [RefSeq, PubMed]; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4VAK8;Q1L8C5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000814 ESCRT II complex", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0061360 optic chiasma development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U3V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803I4-1", "uniprot_id": "RING2_DANRE", "mass": 37539.0, "length": 336, "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "rnf2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rnf2; fa19h05; ring1b; wu:fa19h05; wz4556; wz4566", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING2; 2.3.2.27; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2; RING1b", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); spina bifida (Disease Ontology:DOID:0080016); cancer (Disease Ontology:DOID:162); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (dre:327035); (R-DRE-2559580); (R-DRE-3108214); (R-DRE-3899300); (R-DRE-4570464); (R-DRE-8939243); (R-DRE-8953750)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11120825;12036288;12242588;15520368;19897725;29985950;30867528;34534441;34768802;36117635", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PUR9;Q9PTH4", "ec_number_list": "2.7.11.1;2.3.2.27;2.7.11.24;2.3.2.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0000151 ubiquitin ligase complex;GO:0005694 chromosome", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0060042 retina morphogenesis in camera-type eye;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q803I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q708S8-1", "uniprot_id": "ASI1B_DANRE", "mass": 63540.0, "length": 557, "protein_name": "Acid-sensing ion channel 1B", "gene_name": "asic1b", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 1B", "refseq_ac": "NP_999956", "gene_names_uniprotkb": "asic1b; ASIC1-B; ASIC1; accn2a; zASIC1.1", "gene_names_refseq": "ASIC1-B; ASIC1; accn2a; asic1b; zASIC1.1", "protein_names_uniprotkb": "Acid-sensing ion channel 1B; ASIC1-B; Acid-sensing ion channel 1.1-B; Amiloride-sensitive cation channel 2-A, neuronal-B; ZASIC1.1", "protein_names_refseq": "acid-sensing ion channel 1.1-B; acid-sensing ion channel 1.1; acid-sensing ion channel 1B; amiloride-sensitive cation channel 2 a; amiloride-sensitive cation channel 2-A, neuronal-B; amiloride-sensitive cation channel 2-A, neuronal", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:407672); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14970195", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ609615.1, BC162362.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ609615.1., [RefSeq]; Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:14970195). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:14970195). Displays high selectivity for sodium ions but can also permit the permeation of other cations (By similarity)., [UniProtKB, UniProtKB, PubMed]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0160128 pH-gated monoatomic ion channel activity;GO:0160125 pH-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0071467 cellular response to pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q708S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DG12-1", "uniprot_id": "ARNT2_DANRE", "mass": 80972.0, "length": 737, "protein_name": "Aryl hydrocarbon receptor nuclear translocator 2", "gene_name": "arnt2", "organism": "Zebrafish", "refseq_name": "aryl hydrocarbon receptor nuclear translocator 2", "refseq_ac": "NP_571749", "gene_names_uniprotkb": "arnt2; Arnt; arnt2X; arnt2a; chunp6921; zfARNT2a; zfARNT2b; zfARNT2c; zfARNT2", "gene_names_refseq": "Arnt; arnt2X; arnt2a; arnt2; chunp6921; zfARNT2a; zfARNT2b; zfARNT2c; zfARNT2", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2; zfARNT2", "protein_names_refseq": "ARNT protein 2; Ah receptor nuclear translocator; aryl hydrocarbon receptor nuclear translocator 2; unm t30256; unm_t30256", "tax_id": 7955, "disease": "", "pathway": " (dre:64277); (R-DRE-211945); (R-DRE-211976); (R-DRE-211981); (R-DRE-8937144); (R-DRE-9768919)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10960127;11072074;15282404;37039097", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF219988.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF219988.1. On Jul 6, 2005 this sequence version replaced XP_693809.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos., [RefSeq, PubMed]; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator (PubMed:11072074). Isoform 3 acts as a transcriptional repressor (PubMed:10960127, PubMed:11072074)., [UniProtKB, PubMed, UniProtKB, PubMed]; Zebrafish gene (zfARNT2) is not essential for mediating TCDD developmental toxicity in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DG11;Q9DG13;Q9IAS2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:0021536 diencephalon development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DG12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QFX6-1", "uniprot_id": "NRP1A_DANRE", "mass": 102493.0, "length": 923, "protein_name": "Neuropilin-1a", "gene_name": "nrp1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "nrp1a; np-1; npn-1A; nrp1; zgc:111785; zgc:136674; znrp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropilin-1a; znrp1", "protein_names_refseq": "", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:353246); (R-DRE-194306); (R-DRE-399954); (R-DRE-399956)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12142468", "class_list": "", "function": "Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8AXP1", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0017154 semaphorin receptor activity;GO:0005021 vascular endothelial growth factor receptor activity;GO:0038085 vascular endothelial growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030424 axon;GO:0016020 membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0030900 forebrain development;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QFX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGZ3-1", "uniprot_id": "MIPT3_DANRE", "mass": 72010.0, "length": 629, "protein_name": "TRAF3-interacting protein 1", "gene_name": "traf3ip1", "organism": "Zebrafish", "refseq_name": "TRAF3-interacting protein 1", "refseq_ac": "NP_956894", "gene_names_uniprotkb": "traf3ip1; Elipsa; ift54; zgc:63522", "gene_names_refseq": "Elipsa; ift54; traf3ip1; zgc:63522", "protein_names_uniprotkb": "TRAF3-interacting protein 1", "protein_names_refseq": "TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1; eli; mipt3", "tax_id": 7955, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (dre:393572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26487268", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056776.1, EU117166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056776.1. On Jul 6, 2005 this sequence version replaced XP_702301.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0060271 cilium assembly;GO:0035845 photoreceptor cell outer segment organization;GO:0042073 intraciliary transport;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXN5-1", "uniprot_id": "DNM1L_DANRE", "mass": 77263.0, "length": 691, "protein_name": "Dynamin-1-like protein", "gene_name": "dnm1l", "organism": "Zebrafish", "refseq_name": "dynamin-1-like protein", "refseq_ac": "NP_957216", "gene_names_uniprotkb": "dnm1l; drp1; zgc:66163", "gene_names_refseq": "dnm1l; drp1; zgc:66163", "protein_names_uniprotkb": "Dynamin-1-like protein; 3.6.5.5", "protein_names_refseq": "dynamin-1-like protein", "tax_id": 7955, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 1 (Disease Ontology:DOID:0070347); optic atrophy 5 (Disease Ontology:DOID:0111438); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); dental fluorosis (Disease Ontology:DOID:13711); Parkinson's disease (Disease Ontology:DOID:14330); pulmonary fibrosis (Disease Ontology:DOID:3770); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393896); (R-DRE-75153)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055521.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055521.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (By similarity). May play a role in the circadian control of mitochondrial ATP production (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016559 peroxisome fission;GO:0051259 protein complex oligomerization;GO:0048511 rhythmic process;GO:0043653 mitochondrial fragmentation involved in apoptotic process;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SXN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2E3-1", "uniprot_id": "KC1DA_DANRE", "mass": 46243.0, "length": 403, "protein_name": "Casein kinase I isoform delta-A", "gene_name": "csnk1da", "organism": "Zebrafish", "refseq_name": "casein kinase I isoform delta-A", "refseq_ac": "NP_955877", "gene_names_uniprotkb": "csnk1da; Csnk1d; csnk1dl; si:ch211-234h8.6; wu:fb50c04; zgc:63971", "gene_names_refseq": "Csnk1d; csnk1da; csnk1dl; wu:fb50c04; zgc:63971", "protein_names_uniprotkb": "Casein kinase I isoform delta-A; 2.7.11.1; CKI-delta-A; CKId-A; Casein kinase I isoform delta-like", "protein_names_refseq": "CKI-delta-A; CKId-A; casein kinase 1, delta like; casein kinase I isoform delta-A", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); colon cancer (Disease Ontology:DOID:219)", "pathway": " (dre:322106)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18064361;23349822;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054583.1, EU127826.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054583.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that CK1delta inhibition abolishes rhythmic pineal aanat2 mRNA expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005876 spindle microtubule", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0042752 regulation of circadian rhythm;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T2E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90460-1", "uniprot_id": "C166A_DANRE", "mass": 61274.0, "length": 564, "protein_name": "CD166 antigen homolog A", "gene_name": "alcama", "organism": "Zebrafish", "refseq_name": "CD166 antigen homolog A precursor", "refseq_ac": "NP_571075", "gene_names_uniprotkb": "alcama; DM-GRASP; alcam; cd166", "gene_names_refseq": "DM-GRASP; alcama; alcam; cd166", "protein_names_uniprotkb": "CD166 antigen homolog A; Activated leukocyte cell adhesion molecule A; DM-GRASP homolog; Neurolin", "protein_names_refseq": "CD166 antigen homolog A precursor; CD166 antigen homolog A; DM-GRASP homolog; neurolin-a; neurolin; zn5 / zn-5 antigen; zn8 / zn-8 antigen", "tax_id": 7955, "disease": "", "pathway": " (dre:30194)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "40044042;8026643;8089660", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L25273.1, BC071276.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L25273.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q90480", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6E2N3-1", "uniprot_id": "TRI33_DANRE", "mass": 128198.0, "length": 1163, "protein_name": "E3 ubiquitin-protein ligase TRIM33", "gene_name": "trim33", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "trim33; cb1085; id:ibd2175; mon; tif1g; unm_t30813; wu:fc17f10; zgc:136680", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM33; 2.3.2.27; Ectodermin homolog; Protein moonshine; RING-type E3 ubiquitin transferase TRIM33; TIF1-gamma; Transcription intermediary factor 1-gamma; Tripartite motif-containing protein 33", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:324053)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11731487;15314655;35429189;36052696;36420817;37227070;38160724;9007245;9007250;9007251;9007256", "class_list": "", "function": "May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q29RE2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005654 nucleoplasm", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030218 erythrocyte differentiation;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6E2N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803L0-1", "uniprot_id": "LN28A_DANRE", "mass": 21886.0, "length": 202, "protein_name": "Protein lin-28 homolog A", "gene_name": "lin28ab; lin28a", "organism": "Zebrafish", "refseq_name": "protein lin-28 homolog A", "refseq_ac": "NP_957385", "gene_names_uniprotkb": "lin28ab; lin28a; lin28a; lin28; sb:cb650; si:ch211-232d9.4; zgc:55584", "gene_names_refseq": "lin28ab; lin28a; lin28; sb:cb650; zgc:55584", "protein_names_uniprotkb": "Protein lin-28 homolog A; Lin-28A", "protein_names_refseq": "RNA-binding protein lin-28; lin-28A; protein lin-28 homolog A", "tax_id": 7955, "disease": "nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (dre:394066)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18307296;20935637;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044433.1, EH547049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044433.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation. Erratum:[Nat Cell Biol. 2015 Apr;17(4):532. doi: 10.1038/ncb3144. PMID: 25812527], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXL3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0000932 P-body", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0031099 regeneration;GO:0010629 negative regulation of gene expression;GO:0019827 stem cell population maintenance;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q803L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGE2-1", "uniprot_id": "MK14A_DANRE", "mass": 41633.0, "length": 361, "protein_name": "Mitogen-activated protein kinase 14A", "gene_name": "mapk14a", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase 14A", "refseq_ac": "NP_571797", "gene_names_uniprotkb": "mapk14a; MAPK14; fk28c03; hm:zeh1243; mapk14; p38a; p38; wu:fk28c03; zeh1243; zp38a", "gene_names_refseq": "MAPK14; fk28c03; hm:zeh1243; mapk14a; p38a; p38; wu:fk28c03; zeh1243; zp38a", "protein_names_uniprotkb": "Mitogen-activated protein kinase 14A; 2.7.11.24; MAP kinase 14A; MAP kinase p38a; MAPK 14A; Mitogen-activated protein kinase p38a; zp38a", "protein_names_refseq": "MAP kinase 14A; MAP kinase p38a; MAPK 14A; etID18993.8; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38a", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); gastric adenocarcinoma (Disease Ontology:DOID:3717); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:65237); (R-DRE-168638); (R-DRE-171007); (R-DRE-198753); (R-DRE-2559580); (R-DRE-418592); (R-DRE-432142); (R-DRE-4420097); (R-DRE-450302); (R-DRE-450341); (R-DRE-525793); (R-DRE-5668599); (R-DRE-6798695); (R-DRE-6804756); (R-DRE-69601); (R-DRE-9824585)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "10995439", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB030897.1, BC059417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB030897.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. Required for cytokinesis on the future dorsal side of the blastodisc, suggesting a role in symmetrical and synchronous blastomere cleavage., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.99.18;5.6.2.4;2.7.11.1;2.7.1.11;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;3.6.4.13;2.7.1.40;2.7.11.26;2.7.11.31;1.1.1.205;5.4.2.11;5.4.2.4;2.7.1.35;3.1.3.48;1.13.11.34;3.2.1.31;3.6.5.-;2.3.2.27;3.6.4.6;4.1.2.13;1.11.1.6", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0040016 embryonic cleavage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DGE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SY24-1", "uniprot_id": "KPCB_DANRE", "mass": 76306.0, "length": 670, "protein_name": "Protein kinase C beta type", "gene_name": "prkcbb", "organism": "Zebrafish", "refseq_name": "protein kinase C beta type", "refseq_ac": "NP_957272", "gene_names_uniprotkb": "prkcbb; PKC-B; Prkcb; prkcb1; zgc:63591", "gene_names_refseq": "PKC-B; Prkcb; prkcb1; prkcbb; zgc:63591", "protein_names_uniprotkb": "Protein kinase C beta type; 2.7.11.13; PKC-B; PKC-beta", "protein_names_refseq": "PKC-beta; protein kinase C beta type; protein kinase C, beta 1", "tax_id": 7955, "disease": "silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:393953); (R-DRE-114516); (R-DRE-1169091); (R-DRE-416993); (R-DRE-4419969); (R-DRE-5099900); (R-DRE-5218921); (R-DRE-5668599); (R-DRE-76005)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055154.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055154.1. On Jul 6, 2005 this sequence version replaced XP_697073.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7SY24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98UK5-1", "uniprot_id": "MAFB_DANRE", "mass": 40233.0, "length": 356, "protein_name": "Transcription factor MafB", "gene_name": "mafba; mafb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mafba; mafb; kreisler; krml; kr; mafba; mafb; val; wu:fc22d11; wu:fj82a09", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor MafB; Maf-B; Transcription factor Val; Valentino", "protein_names_refseq": "", "tax_id": 7955, "disease": "Duane retraction syndrome 3 (Disease Ontology:DOID:0061029); multicentric carpotarsal osteolysis syndrome (Disease Ontology:DOID:0111534); Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (dre:30210)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10207156;10331983;10683174;11134968;11543616;36205309;37752184;37968389;38017520;38722096;9012518;9425134;9853959", "class_list": "", "function": "May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73679", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021571 rhombomere 5 development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q98UK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZK7-1", "uniprot_id": "OFD1_DANRE", "mass": 103862.0, "length": 901, "protein_name": "Centriole and centriolar satellite protein ofd1", "gene_name": "ofd1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ofd1; wu:fa07a10; wu:fd17e11; zgc:92562", "gene_names_refseq": "", "protein_names_uniprotkb": "Centriole and centriolar satellite protein ofd1; Oral-facial-digital syndrome 1 protein homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "orofaciodigital syndrome I (Disease Ontology:DOID:0060316); Simpson-Golabi-Behmel syndrome type 2 (Disease Ontology:DOID:0080342); retinitis pigmentosa 23 (Disease Ontology:DOID:0110412); Joubert syndrome 10 (Disease Ontology:DOID:0110981); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:327216)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11116086;12782125;12913139;16109975;18971206;24691443;26469318;31048868;36862758;37898820", "class_list": "", "function": "Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0030030 cell projection organization;GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry;GO:0061371 determination of heart left/right asymmetry;GO:0060026 convergent extension;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7SZK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JG38-1", "uniprot_id": "FGFR2_DANRE", "mass": 91388.0, "length": 817, "protein_name": "Fibroblast growth factor receptor 2", "gene_name": "fgfr2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "fgfr2; fc56c05; fgfr-2; fgfr2b; fgfr2c; wu:fc56c05", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor 2; 2.7.10.1; FGFR-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); Beare-Stevenson cutis gyrata syndrome (Disease Ontology:DOID:0050660); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); bent bone dysplasia syndrome 1 (Disease Ontology:DOID:0060992); bone disease (Disease Ontology:DOID:0080001); Antley-Bixler syndrome (Disease Ontology:DOID:0081289); Antley-Bixler syndrome without disordered steroidogenesis (Disease Ontology:DOID:0081290); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); prostate cancer (Disease Ontology:DOID:10283); intestinal atresia (Disease Ontology:DOID:10486); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); essential hypertension (Disease Ontology:DOID:10825); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); acrocephalosyndactylia (Disease Ontology:DOID:12960); primary pulmonary hypertension (Disease Ontology:DOID:14557); Pfeiffer syndrome (Disease Ontology:DOID:14705); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); Crouzon syndrome (Disease Ontology:DOID:2339); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); high grade glioma (Disease Ontology:DOID:3070); dysgerminoma (Disease Ontology:DOID:4441); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); female breast carcinoma (Disease Ontology:DOID:7843); intestinal volvulus (Disease Ontology:DOID:8445); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": " (dre:352940); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190375); (R-DRE-190377); (R-DRE-5654221); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654727); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "14516681;16077091;16109975;16488878;36841347;36910471;36994096;37107596;37783119;8622866", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137;3.1.3.48", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JG38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYW6-1", "uniprot_id": "CLAP2_DANRE", "mass": 140303.0, "length": 1288, "protein_name": "CLIP-associating protein 2", "gene_name": "clasp2", "organism": "Zebrafish", "refseq_name": "CLIP-associating protein 2 isoform 2", "refseq_ac": "NP_996955", "gene_names_uniprotkb": "clasp2; zgc:77279", "gene_names_refseq": "clasp2; zgc:77279", "protein_names_uniprotkb": "CLIP-associating protein 2; Cytoplasmic linker-associated protein 2", "protein_names_refseq": "CLIP-associating protein 2 isoform 2; CLIP-associating protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:404604); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "15520368;21468032;26469318;27189481;28252024;32173581;34782579;35705037;38066968", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066436.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505373, SAMEA3505379 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development., [RefSeq, PubMed]; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0031252 cell leading edge", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0010458 exit from mitosis;GO:0007020 microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NYW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDT5-1", "uniprot_id": "SPT5H_DANRE", "mass": 120379.0, "length": 1084, "protein_name": "Transcription elongation factor SPT5", "gene_name": "supt5h", "organism": "Zebrafish", "refseq_name": "transcription elongation factor SPT5", "refseq_ac": "NP_571748", "gene_names_uniprotkb": "supt5h; Spt5; etID10129.15; etID37101.15; fb37g01; fb95e05; foggy; fog; spt5; wu:fb37g01; wu:fb95e05; wu:fc10f02", "gene_names_refseq": "Spt5; etID10129.15; etID37101.15; fb37g01; fb95e05; foggy; fog; supt5h; wu:fb37g01; wu:fb95e05; wu:fc10f02", "protein_names_uniprotkb": "Transcription elongation factor SPT5; DRB sensitivity-inducing factor large subunit; DSIF large subunit; Protein foggy", "protein_names_refseq": "DRB sensitivity-inducing factor large subunit; DSIF large subunit; protein foggy; suppressor of Ty 5 homolog; transcription elongation factor SPT5; transcription elongation regulator foggy", "tax_id": 7955, "disease": "", "pathway": " (dre:64275); (R-DRE-113418); (R-DRE-674695); (R-DRE-6796648); (R-DRE-6807505); (R-DRE-72086); (R-DRE-75955); (R-DRE-77075)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "10191060;11099044;11923199;15044455;16193504;18307296;18978947;21205096;25556858;27520065;27544571;32784920", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF288409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476742 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Jun 25, 2025 this sequence version replaced NP_571748.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:11923199). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (By similarity). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (By similarity). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (By similarity). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (By similarity). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (By similarity). Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (PubMed:11099044)., [UniProtKB, PubMed, PubMed, UniProtKB]; Spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration, [RefSeq, PubMed]; The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFJ3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0030097 hemopoiesis;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DDT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3E5-1", "uniprot_id": "KAT3_DANRE", "mass": 50345.0, "length": 450, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "kyat3.2; kyat3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "kyat3.2; kyat3; ccbl2; kat3; kyat3; zgc:63929", "gene_names_refseq": "", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; KATIII; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:393315)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28077310;28132765", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.4.1.13;2.6.1.63;2.6.1.7;2.6.1.39;2.6.1.4;2.6.1.73;2.6.1.1", "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0070189 kynurenine metabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T3E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9QEA0-1", "uniprot_id": "A0A8M9QEA0_DANRE", "mass": 149221.0, "length": 1336, "protein_name": "Histone-lysine N-methyltransferase PRDM16 isoform X1", "gene_name": "prdm16", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase PRDM16 isoform X1", "refseq_ac": "XP_021334166", "gene_names_uniprotkb": "prdm16", "gene_names_refseq": "prdm16", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM16 isoform X1", "protein_names_refseq": "histone-lysine N-methyltransferase PRDM16 isoform X1", "tax_id": 7955, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); dilated cardiomyopathy 1LL (Disease Ontology:DOID:0081157)", "pathway": " (dre:796720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0060047 heart contraction;GO:0060218 hematopoietic stem cell differentiation;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QEA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9P9-1", "uniprot_id": "SMAD2_DANRE", "mass": 52453.0, "length": 468, "protein_name": "SMAD family member 2", "gene_name": "smad2", "organism": "Zebrafish", "refseq_name": "SMAD family member 2", "refseq_ac": "NP_001276944", "gene_names_uniprotkb": "smad2; fj43c06; madh2; wu:fj43c06", "gene_names_refseq": "fj43c06; madh2; smad2; wu:fj43c06", "protein_names_uniprotkb": "SMAD family member 2; MAD homolog 2; Mothers against DPP homolog 2; Mothers against decapentaplegic homolog 2; SMAD 2", "protein_names_refseq": "MAD homolog 2; SMA- and MAD-related protein 2; SMAD family member 2; mothers against DPP homolog 2; mothers against decapentaplegic homolog 2", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Loeys-Dietz syndrome 6 (Disease Ontology:DOID:0060964); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:30639); (R-DRE-1502540); (R-DRE-2173788); (R-DRE-2173789); (R-DRE-2173795); (R-DRE-5689880)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10525190;10767528;23591895;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395050.991489.1, SRR32588731.1805900.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Feb 20, 2014 this sequence version replaced XP_005155614.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V964;Q9PUN4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0001714 endodermal cell fate specification;GO:0007501 mesodermal cell fate specification;GO:0060282 positive regulation of oocyte development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9I9P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q804Q5-1", "uniprot_id": "FEZF2_DANRE", "mass": 47541.0, "length": 430, "protein_name": "Fez family zinc finger protein 2", "gene_name": "fezf2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "fezf2; SI:dZ6A2.1; SI:dZ6A2.7; cadps; fezl; fez; foreheadin; tof; zgc:92690", "gene_names_refseq": "", "protein_names_uniprotkb": "Fez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Foreheadin protein; Zinc finger protein Fez-like", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:60634)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10191060;11025224;11180958;12469125;15219677;16109975;23594743;33527896;34876587;34923164;38253686;38908500", "class_list": "", "function": "Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U371;Q90ZY2;Q9DGC4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0021536 diencephalon development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q804Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90268-1", "uniprot_id": "PAX2A_DANRE", "mass": 44099.0, "length": 410, "protein_name": "Paired box protein Pax-2a", "gene_name": "pax2a", "organism": "Zebrafish", "refseq_name": "paired box protein Pax-2a", "refseq_ac": "NP_571259", "gene_names_uniprotkb": "pax2a; PAXZF-B; Pax-2; cb378; noi; pax-b; pax2.1; pax2a1; pax[zf-b]; paxb; paxzf-b", "gene_names_refseq": "PAXZF-B; Pax-2; cb378; noi; pax-b; pax2.1; pax2a1; pax2a; pax[zf-b]; paxb", "protein_names_uniprotkb": "Paired box protein Pax-2a; No isthmus protein; Pax[Zf-b]", "protein_names_refseq": "no isthmus protein; paired box gene 2.1; paired box gene 2a; paired box homeotic gene 2a; paired box protein Pax-2a", "tax_id": 7955, "disease": "renal coloboma syndrome (Disease Ontology:DOID:0090006); focal segmental glomerulosclerosis 7 (Disease Ontology:DOID:0111132); coloboma (Disease Ontology:DOID:12270); nephroblastoma (Disease Ontology:DOID:2154); renal Wilms' tumor (Disease Ontology:DOID:5176); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dre:30425)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1811936;9671579", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066690.1, X63961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066690.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWK8;Q9PWK9;Q9PWL0;Q9PWL1;Q9YGU5;Q9YGU6;Q9YGU7;Q9YGU8;Q9YGU9;Q9YGV0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0009952 anterior/posterior pattern specification;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZT82-1", "uniprot_id": "RFX1L_DANRE", "mass": 40271.0, "length": 382, "protein_name": "RNA binding protein fox-1 homolog 1-like", "gene_name": "rbfox1l", "organism": "Zebrafish", "refseq_name": "RNA binding protein fox-1 homolog 1-like", "refseq_ac": "NP_999940", "gene_names_uniprotkb": "rbfox1l; Fox-1; a2bp1l; fox1l; fox1; hm:zeh0082; si:ch211-57k11.1; zeh0082", "gene_names_refseq": "Fox-1; a2bp1l; fox1l; hm:zeh0082; rbfox1l; zeh0082", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 1-like; Ataxin 2-binding protein 1-like; Fox-1 homolog-like protein 1", "protein_names_refseq": "RNA binding protein fox-1 homolog 1-like; RNA-binding protein; ZFmu1A11s; ataxin 2-binding protein 1-like; fox-1 homolog-like protein 1", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:407613)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12574126;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB074763.1, BC163738.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB074763.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons., [UniProtKB, PubMed]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0048741 skeletal muscle fiber development;GO:0008380 RNA splicing;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZT82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYG3-1", "uniprot_id": "TTK_DANRE", "mass": 110012.0, "length": 982, "protein_name": "Dual specificity protein kinase Ttk", "gene_name": "ttk", "organism": "Zebrafish", "refseq_name": "dual specificity protein kinase Ttk", "refseq_ac": "NP_778207", "gene_names_uniprotkb": "ttk; mps1; ncp", "gene_names_refseq": "mps1; ncp; ttk", "protein_names_uniprotkb": "Dual specificity protein kinase Ttk; 2.7.12.1; Mitotic checkpoint serine/threonine-protein kinase Mps1; Monopolar spindle protein 1; Protein nightcap", "protein_names_refseq": "dual specificity protein kinase Ttk; mitotic checkpoint serine/threonine-protein kinase Mps1; monopolar spindle 1; monopolar spindle protein 1; protein nightcap", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); bipolar disorder (Disease Ontology:DOID:3312); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:317763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12399306;12481136;15231734", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF488735.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF488735.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (By similarity). Required to prevent chromosome segregation errors during meiosis (PubMed:15231734). Required for fin and heart regeneration (PubMed:12399306, PubMed:12481136)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Mps1 is a critical regulator of chromosome number in zebrafish, [RefSeq, PubMed]; The proximal blastema comprises an essential subpopulation of the fin regenerate defined by the induction and function of Mps1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T2A4", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0016321 female meiosis chromosome segregation;GO:0033316 meiotic spindle assembly checkpoint signaling;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8AYG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UVC1-1", "uniprot_id": "INVS_DANRE", "mass": 113034.0, "length": 1021, "protein_name": "Inversin", "gene_name": "invs", "organism": "Zebrafish", "refseq_name": "inversin", "refseq_ac": "NP_694502", "gene_names_uniprotkb": "invs; wu:fe47e11", "gene_names_refseq": "invs; wu:fe47e11", "protein_names_uniprotkb": "Inversin", "protein_names_refseq": "inversin", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); nephronophthisis 2 (Disease Ontology:DOID:0111113); hypertension (Disease Ontology:DOID:10763); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dre:245946)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11941489;12872123;15852005;37352572", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF465261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMN06350655 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF465261.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation., [RefSeq, PubMed]; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005929 cilium", "go_biological_process": "GO:0010171 body morphogenesis;GO:0001822 kidney development;GO:0016055 Wnt signaling pathway;GO:0001947 heart looping;GO:0035844 cloaca development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8UVC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYN5-1", "uniprot_id": "RXRBA_DANRE", "mass": 51597.0, "length": 471, "protein_name": "Retinoic acid receptor RXR-beta-A", "gene_name": "rxrba", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor RXR-beta-A isoform 2", "refseq_ac": "NP_571350", "gene_names_uniprotkb": "rxrba; NR2B2-A; RXRA; RXR; etID309733.19; fb93c09; nr2b2a; rxrb; rxre; wu:fb93c09", "gene_names_refseq": "NR2B2-A; RXRA; RXR; etID309733.19; fb93c09; rxrba; rxrb; rxre; wu:fb93c09", "protein_names_uniprotkb": "Retinoic acid receptor RXR-beta-A; Nuclear receptor subfamily 2 group B member 2-A; Retinoid X receptor beta-A", "protein_names_refseq": "nuclear receptor subfamily 2 group B member 2-A; retinoic acid receptor RXR-beta-A isoform 2; retinoic acid receptor RXR-beta-A; retinoid X receptor beta-A; retinoid receptor-epsilon; retinoid x receptor, epsilon", "tax_id": 7955, "disease": "", "pathway": " (dre:30530); (R-DRE-383280); (R-DRE-5362517); (R-DRE-9029569); (R-DRE-9623433)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12869198;15464576;15718292;15889082;16448862;23594743;34089732;34111665;35588359;36716661;36835354;7565671;9192646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.25988638.1, SRR32588730.17237485.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Jul 24, 2023 this sequence version replaced XP_009292301.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O42556;Q1LV98;Q8AW18;Q90418", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7SYN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DGS3-1", "uniprot_id": "KC2D2_DANRE", "mass": 62384.0, "length": 554, "protein_name": "Calcium/calmodulin-dependent protein kinase type II delta 2 chain", "gene_name": "camk2d2", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase type II delta 2 chain", "refseq_ac": "NP_001002542", "gene_names_uniprotkb": "camk2d2; camk2da; camk2d; wu:fq17a12; zgc:92792", "gene_names_refseq": "camk2d2; camk2da; camk2d; wu:fq17a12; zgc:92792", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II delta 2 chain; 2.7.11.17; CaM kinase II subunit delta-A; CaM-kinase II delta-A chain; CaMK-II subunit delta-A; Calcium/calmodulin-dependent protein kinase type II delta-A chain", "protein_names_refseq": "caM kinase II subunit delta-A; caM-kinase II delta-A chain; caMK-II subunit delta-A; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta a; calcium/calmodulin-dependent protein kinase type II delta 2 chain; calcium/calmodulin-dependent protein kinase type II delta-A chain", "tax_id": 7955, "disease": "heart conduction disease (Disease Ontology:DOID:10273); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:436815); (R-DRE-3371571); (R-DRE-438066); (R-DRE-877300)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "17103413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076266.1, BC154768.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076266.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8WGM2", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection;GO:0043226 organelle", "go_biological_process": "GO:1903076 regulation of protein localization to plasma membrane;GO:0048168 regulation of neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DGS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90270-1", "uniprot_id": "PO5F1_DANRE", "mass": 51505.0, "length": 472, "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "pou5f1; pou5f3", "organism": "Zebrafish", "refseq_name": "POU domain, class 5, transcription factor 1", "refseq_ac": "NP_571187", "gene_names_uniprotkb": "pou5f1; pou5f3; POU-2; cb197; chunp6868; etID49452.21; gp-9; gp9; oct4; pou-2; pou2; pou5f1; spg; wu:fd18d06", "gene_names_refseq": "POU-2; cb197; chunp6868; etID49452.21; gp-9; gp9; oct4; pou2; pou5f1; pou5f3; spg/pou2; spg; wu:fd18d06", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 1; POU domain protein 2", "protein_names_refseq": "POU domain gene 2; POU domain protein 2; POU domain, class 5, transcription factor 1; spiel-ohne-grenzen/pou2", "tax_id": 7955, "disease": "transitional cell carcinoma (Disease Ontology:DOID:2671); embryonal carcinoma (Disease Ontology:DOID:3308); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (dre:30333)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "38908828;7669688;8288127", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X84224.1, BC049295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708832, SAMEA898399 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X84224.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation., [UniProtKB]; The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90483", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DH13-1", "uniprot_id": "RBP2A_DANRE", "mass": 21686.0, "length": 199, "protein_name": "RNA-binding protein, mRNA-processing factor 2a", "gene_name": "rbpms2a", "organism": "Zebrafish", "refseq_name": "RNA-binding protein, mRNA-processing factor 2a", "refseq_ac": "NP_001002409", "gene_names_uniprotkb": "rbpms2a; hermesa; zgc:92689", "gene_names_refseq": "rbpms2a; zgc:92689", "protein_names_uniprotkb": "RNA-binding protein, mRNA-processing factor 2a; Heart and RRM expressed sequence; Protein hermes A; hermes; rbpms2a", "protein_names_refseq": "RNA binding protein with multiple splicing 2a; RNA-binding protein, mRNA-processing factor 2a; heart and RRM expressed sequence; hermes; protein hermes A", "tax_id": 7955, "disease": "", "pathway": " (dre:436682)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18582455;23594743;23785151;24496621;27974617;36367103", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076171.1, EH539300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076171.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function., [RefSeq, PubMed]; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). RNA-binding protein localized in Balbiani body (electron-dense aggregates in the oocyte) and germ plasm during oogenesis, and may be required to maintain germ plasm mRNA translational repression (PubMed:18582455). Translational regulator during topographic map formation in the visual system (PubMed:27974617). Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Acts as a pre-mRNA alternative splicing regulator. Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0060047 heart contraction;GO:0003007 heart morphogenesis;GO:0048813 dendrite morphogenesis;GO:0051151 negative regulation of smooth muscle cell differentiation;GO:0031290 retinal ganglion cell axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6DH13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98867-1", "uniprot_id": "THAA_DANRE", "mass": 48728.0, "length": 427, "protein_name": "Thyroid hormone receptor alpha-A", "gene_name": "thraa", "organism": "Zebrafish", "refseq_name": "thyroid hormone receptor alpha-A", "refseq_ac": "NP_571471", "gene_names_uniprotkb": "thraa; TR[a]1; nr1a1a; nr1a1; thr1; thraa1; thral; thra; tra1; tra; wu:fb59g07", "gene_names_refseq": "TR[a]1; nr1a1; thr1; thraa; thral; thra; tra1; tra; wu:fb59g07", "protein_names_uniprotkb": "Thyroid hormone receptor alpha-A; Nuclear receptor subfamily 1 group A member 1-A; TRalpha-1; Thyroid hormone receptor alpha-1; zTRalpha-A", "protein_names_refseq": "NR1A1-A; TRalpha-1; c-erbA; nr1a1a; nuclear receptor subfamily 1 group A member 1-A; thyroid hormone receptor alpha-1; thyroid hormone receptor alpha-A; zTRalpha-A", "tax_id": 7955, "disease": "congenital nongoitrous hypothyroidism 6 (Disease Ontology:DOID:0070128); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:30670); (R-DRE-383280)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17583703;23594743;9447705", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U54796.1, BC096778.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U54796.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0ST47;Q4V9Q5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q98867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91428-1", "uniprot_id": "GATA3_DANRE", "mass": 47590.0, "length": 438, "protein_name": "Transcription factor GATA-3", "gene_name": "gata3", "organism": "Zebrafish", "refseq_name": "transcription factor GATA-3", "refseq_ac": "NP_571286", "gene_names_uniprotkb": "gata3; cb550; gta3", "gene_names_refseq": "cb550; gata3; gta3", "protein_names_uniprotkb": "Transcription factor GATA-3; GATA-binding factor 3", "protein_names_refseq": "GATA-binding factor 3; transcription factor GATA-3", "tax_id": 7955, "disease": "colitis (Disease Ontology:DOID:0060180); hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); hypoparathyroidism-deafness-renal disease syndrome (Disease Ontology:DOID:0060878); sensorineural hearing loss (Disease Ontology:DOID:10003); hypoparathyroidism (Disease Ontology:DOID:11199); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (dre:30458); (R-DRE-8939236); (R-DRE-9018519); (R-DRE-983231)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23594743;7547465", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S80425.1, BC162389.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S80425.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061026 cardiac muscle tissue regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JAN0-1", "uniprot_id": "AGRV1_DANRE", "mass": 674630.0, "length": 6199, "protein_name": "Adhesion G protein-coupled receptor V1", "gene_name": "adgrv1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "adgrv1; gpr98; mass1; vlgr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor V1; 3.4.-.-; G protein-coupled receptor 98; Monogenic audiogenic seizure susceptibility protein 1 homolog; Very large G protein-coupled receptor 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "Usher syndrome type 2C (Disease Ontology:DOID:0110839); familial febrile seizures 4 (Disease Ontology:DOID:0111305); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:415105)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15979825;16109975;20440071;24626987;25715737;26469318;27189481;35079792;37337429;37371069", "class_list": "", "function": "Receptor that may have an important role in the development of the sensory nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016787 hydrolase activity;GO:0001965 G-protein alpha-subunit binding;GO:0010855 adenylate cyclase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0032420 stereocilium;GO:0060171 stereocilium membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0071277 cellular response to calcium ion;GO:0007601 visual perception;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6JAN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Y57-1", "uniprot_id": "JAG1A_DANRE", "mass": 135343.0, "length": 1242, "protein_name": "Protein jagged-1a", "gene_name": "jag1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "jag1a; cb243; jag1; sb:cb243; serrateC", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein jagged-1a; Jagged1a; Jagged1", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)", "pathway": " (dre:140421)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions., [UniProtKB]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:0007219 Notch signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:1901222 regulation of non-canonical NF-kappaB signal transduction;GO:1902038 positive regulation of hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q90Y57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AXX2-1", "uniprot_id": "TBX1_DANRE", "mass": 51551.0, "length": 460, "protein_name": "T-box transcription factor TBX1", "gene_name": "tbx1", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX1", "refseq_ac": "NP_899182", "gene_names_uniprotkb": "tbx1; mp:zf637-3-000616; zgc:136724", "gene_names_refseq": "mp:zf637-3-000616; tbx1; zgc:136724", "protein_names_uniprotkb": "T-box transcription factor TBX1; T-box protein 1", "protein_names_refseq": "T-box 1; T-box protein 1; T-box transcription factor TBX1; van gogh; vgo", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); DiGeorge syndrome (Disease Ontology:DOID:11198); hypoparathyroidism (Disease Ontology:DOID:11199); velocardiofacial syndrome (Disease Ontology:DOID:12583); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); epilepsy (Disease Ontology:DOID:1826); acute kidney failure (Disease Ontology:DOID:3021); tetralogy of Fallot (Disease Ontology:DOID:6419); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dre:368206)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12952905;12972000", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY151388.1, BC115243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY151388.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable transcriptional regulator involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Is required for normal development of the pharyngeal arch arteries (By similarity). Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZZB6", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0048752 semicircular canal morphogenesis;GO:0060017 parathyroid gland development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8AXX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IBD0-1", "uniprot_id": "CELF1_DANRE", "mass": 53608.0, "length": 501, "protein_name": "CUGBP Elav-like family member 1", "gene_name": "celf1", "organism": "Zebrafish", "refseq_name": "CUGBP Elav-like family member 1 isoform 2", "refseq_ac": "NP_001315342", "gene_names_uniprotkb": "celf1; CELF-1; brul; cb920; cugbp1; im:7151366; si:dkey-30l20.6", "gene_names_refseq": "CELF-1; brul; cb920; celf1; cugbp1; im:7151366; si:dkey-30l20.6", "protein_names_uniprotkb": "CUGBP Elav-like family member 1; Bruno-like protein 2; CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; EDEN-BP/Bruno-like protein; RNA-binding protein BRUNOL-2", "protein_names_refseq": "CUG triplet repeat, RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUGBP Elav-like family member 1 isoform 2; EDEN-BP/Bruno-like protein; RNA-binding protein BRUNOL-2; bruno-like protein 2", "tax_id": 7955, "disease": "", "pathway": " (dre:58137)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10781958;11895477;16168720", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049453.1, SRR32588734.645104.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1 and CT636421.2. On Jun 15, 2016 this sequence version replaced XP_005169052.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Not only mRNA but also protein of brul is localized to the zebrafish germ plasm at the ends of the cleavage furrows, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWE4", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0045495 pole plasm", "go_biological_process": "GO:0001889 liver development;GO:0016477 cell migration;GO:0048588 developmental cell growth;GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9IBD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P949-1", "uniprot_id": "PHF2_DANRE", "mass": 118582.0, "length": 1063, "protein_name": "Lysine-specific demethylase phf2", "gene_name": "phf2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "phf2; im:4200679; phf8; wu:fa14c10", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase phf2; 1.14.11.-; PHD finger protein 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309)", "pathway": " (dre:503778); (R-DRE-3214842)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E7EZ72", "ec_number_list": "1.14.11.-;1.14.11.65", "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0003713 transcription coactivator activity;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0000776 kinetochore", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006482 protein demethylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PH17-1", "uniprot_id": "ATAT_DANRE", "mass": 33202.0, "length": 297, "protein_name": "Alpha-tubulin N-acetyltransferase 1", "gene_name": "atat1", "organism": "Zebrafish", "refseq_name": "alpha-tubulin N-acetyltransferase 1 isoform 2", "refseq_ac": "NP_001315192", "gene_names_uniprotkb": "atat1; ATAT1; MEC17; TAT; mec17; si:ch211-152p11.5; wu:fj19c03; zgc:65893; zgc:77443", "gene_names_refseq": "TAT; atat1; mec17; wu:fj19c03; zgc:65893; zgc:77443", "protein_names_uniprotkb": "Alpha-tubulin N-acetyltransferase 1; 2.3.1.108; Acetyltransferase mec-17 homolog; Alpha-TAT1; Alpha-TAT; TAT", "protein_names_refseq": "MEChanosensory abnormality homolog; alpha-tubulin N-acetyltransferase 1 isoform 2", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:406389)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20829795;23105108;23128673;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056749.1, SRR32588729.1059099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1 and BC056749.1. On Jun 10, 2016 this sequence version replaced XP_005170079.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus., [RefSeq, PubMed]; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZT0", "ec_number_list": "2.3.1.108", "go_molecular_function": "GO:0004468 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;GO:0019799 tubulin N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0005905 clathrin-coated pit;GO:0005925 focal adhesion", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0048666 neuron development;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0071929 alpha-tubulin acetylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PH17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NW59-1", "uniprot_id": "ATF4_DANRE", "mass": 36605.0, "length": 339, "protein_name": "Cyclic AMP-dependent transcription factor ATF-4", "gene_name": "atf4a; atf4", "organism": "Zebrafish", "refseq_name": "cyclic AMP-dependent transcription factor ATF-4", "refseq_ac": "NP_998398", "gene_names_uniprotkb": "atf4a; atf4; atf4a; atf4b1; atf4; wu:fj01c08; wu:fk30b04; zgc:85951", "gene_names_refseq": "atf4a; atf4b1; atf4; wu:fj01c08; wu:fk30b04; zgc:85951", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-4; Activating transcription factor 4; cAMP-dependent transcription factor ATF-4", "protein_names_refseq": "activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor 4b1 (tax-responsive enhancer element B67); cAMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4", "tax_id": 7955, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); borna disease (Disease Ontology:DOID:5154); pulmonary venoocclusive disease (Disease Ontology:DOID:5453)", "pathway": " (dre:406514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067714.1, CK025035.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067714.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (By similarity). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, atf4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to eif2s1/eIF-2-alpha phosphorylation, and stress-induced atf4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). In the absence of stress, atf4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation by promoting expression of osteoblast-specific genes (By similarity). Regulates the circadian expression of the core clock components. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:1990590 ATF1-ATF4 transcription factor complex;GO:1990589 ATF4-CREB1 transcription factor complex", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6NW59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6SJP8-1", "uniprot_id": "FG17_DANRE", "mass": 25203.0, "length": 215, "protein_name": "Fibroblast growth factor 17", "gene_name": "fgf17", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 17 precursor", "refseq_ac": "NP_999973", "gene_names_uniprotkb": "fgf17; fgf17b; si:ch211-237h13.2; zgc:101759", "gene_names_refseq": "fgf17b; fgf17; zgc:101759", "protein_names_uniprotkb": "Fibroblast growth factor 17; FGF-17b; FGF-17; Fibroblast growth factor 17b", "protein_names_refseq": "FGF-17b; FGF-17; fibroblast growth factor 17 b; fibroblast growth factor 17 precursor; fibroblast growth factor 17b", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 20 with or without anosmia (Disease Ontology:DOID:0090082)", "pathway": " (dre:407737); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190322); (R-DRE-190371); (R-DRE-190372); (R-DRE-190373); (R-DRE-190375); (R-DRE-5654219); (R-DRE-5654221); (R-DRE-5654227); (R-DRE-5654228); (R-DRE-5654687); (R-DRE-5654688); (R-DRE-5654689); (R-DRE-5654693); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654710); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654726); (R-DRE-5654727); (R-DRE-5654732); (R-DRE-5654733); (R-DRE-5658623); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 32, "publication_count": 2, "publication_id_list": "15196956;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY457142.1, BC083269.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY457142.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fgf17b induces expression of the mesodermal marker no tail (ntl) and rescues ntl expression suppressed by overexpression of lefty1 (lft1)., [RefSeq, PubMed]; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V214;B0V215", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0009952 anterior/posterior pattern specification;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6SJP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBJ2-1", "uniprot_id": "CFA20_DANRE", "mass": 22606.0, "length": 192, "protein_name": "Cilia- and flagella-associated protein 20", "gene_name": "cfap20", "organism": "Zebrafish", "refseq_name": "cilia- and flagella-associated protein 20", "refseq_ac": "NP_957105", "gene_names_uniprotkb": "cfap20; zgc:73380", "gene_names_refseq": "cfap20; zgc:73380", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 20", "protein_names_refseq": "UPF0468 protein C16orf80 homolog; cilia- and flagella-associated protein 20", "tax_id": 7955, "disease": "", "pathway": " (dre:393784)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24574454", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH496884.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059688.1., [RefSeq]; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability (PubMed:24574454)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0001895 retina homeostasis;GO:0060271 cilium assembly;GO:2000253 positive regulation of feeding behavior;GO:0065001 specification of axis polarity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PBJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JFR5-1", "uniprot_id": "KITA_DANRE", "mass": 109280.0, "length": 976, "protein_name": "Mast/stem cell growth factor receptor kita", "gene_name": "kita", "organism": "Zebrafish", "refseq_name": "mast/stem cell growth factor receptor kita precursor", "refseq_ac": "NP_571128", "gene_names_uniprotkb": "kita; c-kit; kit; receptor; sparse", "gene_names_refseq": "c-kit; kita; kit; receptor; sparse", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor kita; 2.7.10.1; SCFR; Tyrosine-protein kinase Kit", "protein_names_refseq": "SCFR; c-kit homolog; kit receptor a; mast/stem cell growth factor receptor kita precursor; mast/stem cell growth factor receptor kita; proto-oncogene tyrosine-protein kinase Kit; spa-1; spa; tyrosine kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); gastroschisis (Disease Ontology:DOID:11044); urinary bladder cancer (Disease Ontology:DOID:11054); male infertility (Disease Ontology:DOID:12336); aplastic anemia (Disease Ontology:DOID:12449); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); macrocytic anemia (Disease Ontology:DOID:2361); acute pancreatitis (Disease Ontology:DOID:2913); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); interstitial lung disease (Disease Ontology:DOID:3082); piebaldism (Disease Ontology:DOID:3263); mastocytosis (Disease Ontology:DOID:350); endometrial stromal sarcoma (Disease Ontology:DOID:4226); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); oxyphilic adenoma (Disease Ontology:DOID:5389); nephrolithiasis (Disease Ontology:DOID:585); uterine carcinosarcoma (Disease Ontology:DOID:6171); ileus (Disease Ontology:DOID:8440); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); neurofibroma (Disease Ontology:DOID:962)", "pathway": " (dre:30256); (R-DRE-1257604); (R-DRE-1433557); (R-DRE-1433559); (R-DRE-5673001); (R-DRE-6811558); (R-DRE-9856649)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "10393121;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF153446.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF153446.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5RID5;Q9W755", "ec_number_list": "2.7.10.1;2.7.10.2;3.1.3.48;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.11.13;2.7.1.153;2.7.1.137", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0038093 Fc receptor signaling pathway;GO:1902362 melanocyte apoptotic process;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JFR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q804S5-1", "uniprot_id": "MIB1_DANRE", "mass": 112688.0, "length": 1030, "protein_name": "E3 ubiquitin-protein ligase mib1", "gene_name": "mib1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase mib1", "refseq_ac": "NP_775393", "gene_names_uniprotkb": "mib1; cg5841; chunp6889; fe47f05; im:7148100; mib; wu:fe47f05", "gene_names_refseq": "cg5841; chunp6889; fe47f05; im:7148100; mib1; mib; wu:fe47f05", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase mib1; 2.3.2.27; Protein mind bomb; RING-type E3 ubiquitin transferase mib1", "protein_names_refseq": "E3 ubiquitin-protein ligase mib1; RING-type E3 ubiquitin transferase mib1; mindbomb E3 ubiquitin protein ligase 1; protein mind bomb; white tail; wit", "tax_id": 7955, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:352910)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10074451;12006978;12530964;14579383;15013799;15689380;9806913", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF537301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF537301.1. On May 9, 2003 this sequence version replaced NP_775393.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHG3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0021508 floor plate formation;GO:0060035 notochord cell development;GO:0021520 spinal cord motor neuron cell fate specification;GO:0021546 rhombomere development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q804S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXG4-1", "uniprot_id": "SAE2_DANRE", "mass": 71794.0, "length": 650, "protein_name": "SUMO-activating enzyme subunit 2", "gene_name": "uba2", "organism": "Zebrafish", "refseq_name": "SUMO-activating enzyme subunit 2", "refseq_ac": "NP_998528", "gene_names_uniprotkb": "uba2; sae2b; sae2; si:ch211-149o7.1; uble1b; wu:fi17g06; zgc:66354", "gene_names_refseq": "sae2b; sae2; uba2; uble1b; wu:fi17g06; zgc:66354", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 2; 2.3.2.-; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2", "protein_names_refseq": "SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2b; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1-activating enzyme E1B", "tax_id": 7955, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dre:406672); (R-DRE-3065676); (R-DRE-3065678)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18307296;23594743;34040189;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055614.1, BC164556.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055614.1., [RefSeq]; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MCK7;B0S543;B0S544", "ec_number_list": "2.3.2.-", "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0016925 protein sumoylation;GO:0007420 brain development;GO:0061035 regulation of cartilage development;GO:0033334 fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7SXG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVK3-1", "uniprot_id": "SIR2_DANRE", "mass": 42315.0, "length": 379, "protein_name": "NAD-dependent protein deacetylase sirtuin-2", "gene_name": "sirt2", "organism": "Zebrafish", "refseq_name": "NAD-dependent protein deacetylase sirtuin-2", "refseq_ac": "NP_955890", "gene_names_uniprotkb": "sirt2; wu:fb57d05; zgc:55966; zgc:77003", "gene_names_refseq": "sirt2; wu:fb57d05; zgc:55966; zgc:77003", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-2; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); high grade glioma (Disease Ontology:DOID:3070); intermittent claudication (Disease Ontology:DOID:3669); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:322309); (R-DRE-2995383)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24940000;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045510.1, BC067165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045510.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter (PubMed:24940000). Thereby contributes to regulate expression of vegfa, a key regulator of angiogenesis (PubMed:24940000). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of N(6)-benzoyl (benzoyl) and N(6)-methacryl (methacryl) acyl groups from lysine residues, leading to histone debenzoylation and demethacrylation, respectively (By similarity). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]; NAD-dependent protein deacetylase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.286;2.3.1.-", "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0061433 cellular response to caloric restriction;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZVK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90415-1", "uniprot_id": "RXRAB_DANRE", "mass": 42556.0, "length": 379, "protein_name": "Retinoic acid receptor RXR-alpha-B", "gene_name": "rxrab", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor RXR-alpha-B", "refseq_ac": "NP_571228", "gene_names_uniprotkb": "rxrab; etID309731.5; nr2b1b; rxra; rxrg; rxr", "gene_names_refseq": "etID309731.5; rxrab; rxra; rxrg; rxr", "protein_names_uniprotkb": "Retinoic acid receptor RXR-alpha-B; Nuclear receptor subfamily 2 group B member 1-B; Retinoid X receptor alpha-B", "protein_names_refseq": "NR2B1-A; RXRalpha-A; nuclear receptor subfamily 2 group B member 1-B; retinoic acid receptor RXR-alpha-B; retinoid X receptor alpha-B; retinoid x receptor, gamma", "tax_id": 7955, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prostate carcinoma in situ (Disease Ontology:DOID:8634); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:793011)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16448862;17195188;17997606;7565671", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U29894.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U29894.1. On Nov 15, 2007 this sequence version replaced XP_001332662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid that acts as a transcription factor (PubMed:7565671). Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity). The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity). The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90415-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PEH9-1", "uniprot_id": "S39AA_DANRE", "mass": 95089.0, "length": 847, "protein_name": "Zinc transporter ZIP10", "gene_name": "slc39a10", "organism": "Zebrafish", "refseq_name": "zinc transporter ZIP10 precursor", "refseq_ac": "NP_956965", "gene_names_uniprotkb": "slc39a10; zgc:63552; zip10", "gene_names_refseq": "slc39a10; zgc:63552", "protein_names_uniprotkb": "Zinc transporter ZIP10; Solute carrier family 39 member 10; ZIP-10; Zrt- and Irt-like protein 10", "protein_names_refseq": "ZIP-10; solute carrier family 39 (zinc transporter), member 10; zinc transporter ZIP10 precursor; zinc transporter ZIP10; zrt- and Irt-like protein 10", "tax_id": 7955, "disease": "", "pathway": " (dre:393644)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18477665;23594743;27274087;32517868;37068188", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a., [RefSeq, PubMed]; The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis., [RefSeq, PubMed]; These results provide experimental evidence for metal response elements functioning as repressor elements, implicating MTF1 involvement in the negative regulation of ZIP10., [RefSeq, PubMed]; Zinc-influx transporter (PubMed:18477665). When associated with slc39a6, the heterodimer slc39a10/slc39a6 has a functional role in epithelial-mesenchymal transition (EMT) during embryonic development (PubMed:27274087). Slc39a10/slc39a6 heterodimers play also an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). When associated with slc39a6, the heterodimer controls Ncam1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BF20;F1QP98", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0001837 epithelial to mesenchymal transition;GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PEH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8X3-1", "uniprot_id": "FGFR3_DANRE", "mass": 89716.0, "length": 800, "protein_name": "Fibroblast growth factor receptor 3", "gene_name": "fgfr3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "fgfr3; fc27h01; sb:eu563; wu:fc27h01", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor 3; 2.7.10.1; FGFR-3", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal dominant disease (Disease Ontology:DOID:0050736); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); tonsil squamous cell carcinoma (Disease Ontology:DOID:0050920); scoliosis (Disease Ontology:DOID:0060249); Muenke Syndrome (Disease Ontology:DOID:0060703); bone disease (Disease Ontology:DOID:0080001); hypochondroplasia (Disease Ontology:DOID:0080041); lacrimoauriculodentodigital syndrome 2 (Disease Ontology:DOID:0081371); SADDAN (Disease Ontology:DOID:0111158); camptodactyly-tall stature-scoliosis-hearing loss syndrome (Disease Ontology:DOID:0111160); Crouzon syndrome-acanthosis nigricans syndrome (Disease Ontology:DOID:0111161); epidermal nevus (Disease Ontology:DOID:0111162); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); thanatophoric dysplasia (Disease Ontology:DOID:13481); breast cancer (Disease Ontology:DOID:1612); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); high grade glioma (Disease Ontology:DOID:3070); acanthosis nigricans (Disease Ontology:DOID:3138); chondrosarcoma (Disease Ontology:DOID:3371); Merkel cell carcinoma (Disease Ontology:DOID:3965); bladder urothelial carcinoma (Disease Ontology:DOID:4006); achondroplasia (Disease Ontology:DOID:4480); chronic myeloid leukemia (Disease Ontology:DOID:8552); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:58129); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190371); (R-DRE-190372); (R-DRE-5654227); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654710); (R-DRE-5654732); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "11287195;11861475;12431378;12598696;12900448;14516681;36910471;36979489;37107596;37220911;38697957", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137;3.1.3.48", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9I8X3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWA3-1", "uniprot_id": "RBMX_DANRE", "mass": 41621.0, "length": 379, "protein_name": "RNA-binding motif protein, X chromosome", "gene_name": "rbmx", "organism": "Zebrafish", "refseq_name": "RNA-binding motif protein, X chromosome", "refseq_ac": "NP_997763", "gene_names_uniprotkb": "rbmx; fc66e11; hnRNP G; wu:fb37c07; wu:fc66e11", "gene_names_refseq": "fc66e11; hnRNP G; rbmx; wu:fb37c07; wu:fc66e11", "protein_names_uniprotkb": "RNA-binding motif protein, X chromosome; Heterogeneous nuclear ribonucleoprotein G; hnRNP G", "protein_names_refseq": "RNA-binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Shashi type (Disease Ontology:DOID:0060826); X-linked mental retardation Gustavson type (Disease Ontology:DOID:0081123)", "pathway": " (dre:321860)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;15895365;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049509.1, BC071326.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049509.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain., [UniProtKB, PubMed]; Rbmx is required for normal embryonic development, in particular of the brain, consistent with a role in X-linked mental retardation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TLG7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0017069 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000791 euchromatin;GO:0071013 catalytic step 2 spliceosome;GO:0044530 supraspliceosomal complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZWA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92050-1", "uniprot_id": "WNT5B_DANRE", "mass": 41137.0, "length": 363, "protein_name": "Protein Wnt-5b", "gene_name": "wnt5b", "organism": "Zebrafish", "refseq_name": "protein Wnt-5b precursor", "refseq_ac": "NP_571012", "gene_names_uniprotkb": "wnt5b; CHUNP6928; id:ibd5111; pipetail; ppt; si:ch73-211c7.1; wnt-5; wnt5a; wnt5; wnt[b]; wu:fk85g06", "gene_names_refseq": "CHUNP6928; id:ibd5111; pipetail; ppt; wnt-5; wnt5b; wnt5; wnt[b]; wu:fk85g06", "protein_names_uniprotkb": "Protein Wnt-5b", "protein_names_refseq": "pipe tail; protein Wnt-5b precursor; protein Wnt-5b", "tax_id": 7955, "disease": "leiomyoma (Disease Ontology:DOID:127)", "pathway": " (dre:30105); (R-DRE-3238698); (R-DRE-4086400)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22406073;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01005368.1, GFIL01043393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On or before Apr 11, 2018 this sequence version replaced XP_005164595.1, XP_001336641.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. Regulates convergent extension movements and hypaxial myogenesis during gastrulation via activation of non-canonical Wnt signaling (PubMed:22406073)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A5WVR7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0001525 angiogenesis;GO:0001501 skeletal system development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q92050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90YJ2-1", "uniprot_id": "NGB_DANRE", "mass": 17684.0, "length": 159, "protein_name": "Neuroglobin", "gene_name": "ngb", "organism": "Zebrafish", "refseq_name": "neuroglobin", "refseq_ac": "NP_571928", "gene_names_uniprotkb": "ngb; si:ch211-233n24.2", "gene_names_refseq": "ngb", "protein_names_uniprotkb": "Neuroglobin; 1.7.-.-; Nitrite reductase", "protein_names_refseq": "neuroglobin; nitrite reductase", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); retinal ischemia (Disease Ontology:DOID:12510); transient cerebral ischemia (Disease Ontology:DOID:224); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (dre:100000711); (R-DRE-8981607)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11554744;15140880;16709914;18416560;20417633;21614507;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ315610.1, BI429044.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505379, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ315610.1. On Nov 30, 2007 this sequence version replaced XP_001337187.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide (PubMed:15140880). Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0R176", "ec_number_list": "1.11.1.-;1.15.1.1;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90YJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q708S6-1", "uniprot_id": "ASI1C_DANRE", "mass": 60035.0, "length": 529, "protein_name": "Acid-sensing ion channel 1C", "gene_name": "asic1c", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 1C", "refseq_ac": "NP_999954", "gene_names_uniprotkb": "asic1c; ASIC1-C; ASIC1; accn2c; zASIC1.3", "gene_names_refseq": "ASIC1-C; ASIC1; accn2c; asic1c; zASIC1.3", "protein_names_uniprotkb": "Acid-sensing ion channel 1C; ASIC1-C; Acid-sensing ion channel 1.3-C; Amiloride-sensitive cation channel 2-C, neuronal-C; ZASIC1.3", "protein_names_refseq": "acid-sensing ion channel 1.3-C; acid-sensing ion channel 1.3; acid-sensing ion channel 1C; amiloride-sensitive cation channel 2 c; amiloride-sensitive cation channel 2-C, neuronal-C; amiloride-sensitive cation channel 2-C, neuronal; hest1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:407670)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14970195", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ609617.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ609617.1., [RefSeq]; Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:14970195). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:14970195). Displays high selectivity for sodium ions but can also permit the permeation of other cations (By similarity)., [UniProtKB, PubMed, UniProtKB]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0005261 monoatomic cation channel activity;GO:0160128 pH-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0071467 cellular response to pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q708S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGJ3-1", "uniprot_id": "NPC2_DANRE", "mass": 16306.0, "length": 149, "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "npc2.1; npc2", "organism": "Zebrafish", "refseq_name": "NPC intracellular cholesterol transporter 2 precursor", "refseq_ac": "NP_775331", "gene_names_uniprotkb": "npc2.1; npc2; cb292; npc2; sb:cb292", "gene_names_refseq": "cb292; npc2.1; npc2; sb:cb292", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; 16.5 kDa secretory protein; Epididymal secretory protein E1; Niemann Pick type C2 protein homolog", "protein_names_refseq": "16.5 kDa secretory protein; NPC intracellular cholesterol transporter 2 precursor; NPC intracellular cholesterol transporter 2; Niemann-Pick disease, type C2; epididymal secretory protein E1; niemann Pick type C2 protein homolog", "tax_id": 7955, "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (dre:282673); (R-DRE-6798695); (R-DRE-8964038)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "33722902", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF291663.1, BC045895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF291663.1., [RefSeq]; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol., [UniProtKB, UniProtKB]; The role of Niemann-Pick type C2 in zebrafish embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0032934 sterol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0006954 inflammatory response;GO:0008203 cholesterol metabolic process;GO:0008015 blood circulation;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DGJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0R8-1", "uniprot_id": "SHOT1_DANRE", "mass": 61682.0, "length": 544, "protein_name": "Shootin-1", "gene_name": "shtn1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "shtn1; gb:bc139653; shootin1; si:ch73-56p18.4", "gene_names_refseq": "", "protein_names_uniprotkb": "Shootin-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:407656)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08C01;Q1RLX9", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030426 growth cone;GO:0031252 cell leading edge", "go_biological_process": "GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061163 endoplasmic reticulum polarization;GO:0061573 actin filament bundle retrograde transport;GO:0007409 axonogenesis;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P0R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98TW1-1", "uniprot_id": "NCOA2_DANRE", "mass": 161793.0, "length": 1505, "protein_name": "Nuclear receptor coactivator 2", "gene_name": "ncoa2", "organism": "Zebrafish", "refseq_name": "nuclear receptor coactivator 2", "refseq_ac": "NP_571852", "gene_names_uniprotkb": "ncoa2; grip1; src2; tif2; wu:fc41a10; wu:fe26a11", "gene_names_refseq": "ncoa2; tif2; wu:fc41a10; wu:fe26a11", "protein_names_uniprotkb": "Nuclear receptor coactivator 2; Glucocorticoid receptor-interacting protein 1; NCoA-2; NCoA2; Steroid receptor coactivator 2; Transcriptional intermediary factor 2", "protein_names_refseq": "grip1; nuclear receptor coactivator 2; src2", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); polycystic ovary syndrome (Disease Ontology:DOID:11612); prostate adenocarcinoma (Disease Ontology:DOID:2526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); malignant pleural mesothelioma (Disease Ontology:DOID:7474); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:81884); (R-DRE-159418); (R-DRE-192105); (R-DRE-193368); (R-DRE-193807); (R-DRE-211976); (R-DRE-3214847); (R-DRE-400206); (R-DRE-5625886); (R-DRE-9707564)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "17583703;17997606;18248177;18295965;18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF323989.1, BC163724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF323989.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The tif2 is involved in embryogenesis and in primitive hematopoiesis. tif2-knockdown zebrafish embryos are smaller than controls., [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3DK53", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q98TW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DRG7-1", "uniprot_id": "MYPT1_DANRE", "mass": 117322.0, "length": 1049, "protein_name": "Protein phosphatase 1 regulatory subunit 12A", "gene_name": "ppp1r12a", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1 regulatory subunit 12A", "refseq_ac": "NP_001003870", "gene_names_uniprotkb": "ppp1r12a; mbs; mypt1; si:dkey-28j4.1; unm_p82emcf; zgc:110448", "gene_names_refseq": "ppp1r12a; si:dkey-28j4.1; unm_p82emcf; zgc:110448", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; Protein phosphatase myosin-binding subunit", "protein_names_refseq": "myosin phosphatase target subunit 1; myosin phosphatase-targeting subunit 1; myosin-binding subunit of myosin phosphatase; mypt1; protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase myosin-binding subunit; unm p82emcf", "tax_id": 7955, "disease": "", "pathway": " (dre:445393); (R-DRE-2565942); (R-DRE-5625740)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15256591;18776143;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY648792.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Aug 27, 2015 this sequence version replaced NP_001003870.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mypt1 mediates coordination between mesoderm and endoderm cell movements in order to carefully position the liver primordium such that it receives a Bmp2 signal that is essential for liver formation (Mypt1), [RefSeq, PubMed]; Regulates myosin phosphatase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G0B0;Q5TZ13", "ec_number_list": "", "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0031672 A band;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0001889 liver development;GO:0007165 signal transduction;GO:0007409 axonogenesis;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DRG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9QD64-1", "uniprot_id": "A0A8M9QD64_DANRE", "mass": 170647.0, "length": 1547, "protein_name": "Slit homolog 1 protein", "gene_name": "slit2", "organism": "Zebrafish", "refseq_name": "slit homolog 2 protein isoform X1", "refseq_ac": "XP_021331525", "gene_names_uniprotkb": "slit2", "gene_names_refseq": "slit2", "protein_names_uniprotkb": "Slit homolog 1 protein", "protein_names_refseq": "slit homolog 2 protein isoform X1", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); atrial fibrillation (Disease Ontology:DOID:0060224); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); diabetic retinopathy (Disease Ontology:DOID:8947); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0061360 optic chiasma development;GO:0021631 optic nerve morphogenesis;GO:0021952 central nervous system projection neuron axonogenesis;GO:0007411 axon guidance;GO:0001763 morphogenesis of a branching structure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9QD64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9K7-1", "uniprot_id": "TBX20_DANRE", "mass": 49303.0, "length": 446, "protein_name": "T-box transcription factor TBX20", "gene_name": "tbx20", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX20", "refseq_ac": "NP_571581", "gene_names_uniprotkb": "tbx20; ZF-TBX20; cb826; hrt; whz", "gene_names_refseq": "ZF-TBX20; cb826; hrt; tbx20; whz", "protein_names_uniprotkb": "T-box transcription factor TBX20; H15-related T-box transcription factor hrT; T-box protein 20", "protein_names_refseq": "H15-related T-box transcription factor hrT; T-box 20; T-box protein 20; T-box transcription factor TBX20", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); atrial heart septal defect 4 (Disease Ontology:DOID:0110109); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dre:57936)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10656766;10906473;12397116", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF239664.1, AF253325.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF239664.1. On Jun 18, 2015 this sequence version replaced NP_571581.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Embryos lacking hrT function have dysmorphic hearts and an absence of blood circulation, [RefSeq, PubMed]; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I8L6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0035162 embryonic hemopoiesis;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9I9K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TV19-1", "uniprot_id": "DICER_DANRE", "mass": 210817.0, "length": 1865, "protein_name": "Endoribonuclease Dicer", "gene_name": "dicer1", "organism": "Zebrafish", "refseq_name": "endoribonuclease Dicer", "refseq_ac": "NP_001154925", "gene_names_uniprotkb": "dicer1; fc39d11; fc74b05; wu:fc39d11; wu:fc74b05", "gene_names_refseq": "dicer1; fc39d11; fc74b05; wu:fc39d11; wu:fc74b05", "protein_names_uniprotkb": "Endoribonuclease Dicer; 3.1.26.3", "protein_names_refseq": "Dicer1, Dcr-1 homolog; dsRNA-specific ribonuclease; endoribonuclease Dicer", "tax_id": 7955, "disease": "multinodular goiter (Disease Ontology:DOID:0050489); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); nephroma (Disease Ontology:DOID:0080615); DICER1 syndrome (Disease Ontology:DOID:0081063); stomach cancer (Disease Ontology:DOID:10534); DiGeorge syndrome (Disease Ontology:DOID:11198); dilated cardiomyopathy (Disease Ontology:DOID:12930); middle cerebral artery infarction (Disease Ontology:DOID:3525); pleuropulmonary blastoma (Disease Ontology:DOID:4769); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:324724)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14528306;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.508960.1, SRR32588724.2345566.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jun 25, 2025 this sequence version replaced NP_001154925.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004386 helicase activity;GO:0004525 ribonuclease III activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0035196 miRNA processing;GO:0021591 ventricular system development;GO:0030422 siRNA processing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TV19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PP65-1", "uniprot_id": "A0A8M9PP65_DANRE", "mass": 70229.0, "length": 619, "protein_name": "Delta(14)-sterol reductase LBR", "gene_name": "lbr", "organism": "Zebrafish", "refseq_name": "delta(14)-sterol reductase LBR isoform X1", "refseq_ac": "XP_021324046", "gene_names_uniprotkb": "lbr; sb:cb406; wu:fb75h08; wu:fc47b04; wu:fd36b07; zgc:86649", "gene_names_refseq": "lbr; sb:cb406; wu:fb75h08; wu:fc47b04; wu:fd36b07; zgc:86649", "protein_names_uniprotkb": "Delta(14)-sterol reductase LBR; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; Integral nuclear envelope inner membrane protein; Lamin-B receptor; Sterol C14-reductase", "protein_names_refseq": "delta(14)-sterol reductase LBR isoform X1", "tax_id": 7955, "disease": "Greenberg dysplasia (Disease Ontology:DOID:0111588); primary biliary cholangitis (Disease Ontology:DOID:12236); ichthyosis vulgaris (Disease Ontology:DOID:1702); systemic lupus erythematosus (Disease Ontology:DOID:9074); Pelger-Huet anomaly (Disease Ontology:DOID:9631)", "pathway": " (dre:368360)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324046.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.70", "go_molecular_function": "GO:0003677 DNA binding;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0042074 cell migration involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PP65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQF2-1", "uniprot_id": "A0A8M9PQF2_DANRE", "mass": 287498.0, "length": 2501, "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "sptan1", "organism": "Zebrafish", "refseq_name": "spectrin alpha chain, non-erythrocytic 1 isoform X1", "refseq_ac": "XP_021324499", "gene_names_uniprotkb": "sptan1; im:7157190; spna2; wu:fa20e05; wu:fb33g08; wu:fk32a10; zgc:112229", "gene_names_refseq": "im:7157190; spna2; sptan1; wu:fa20e05; wu:fb33g08; wu:fk32a10; zgc:112229", "protein_names_uniprotkb": "Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain", "protein_names_refseq": "spectrin alpha chain, non-erythrocytic 1 isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 91 (Disease Ontology:DOID:0070643); developmental and epileptic encephalopathy 5 (Disease Ontology:DOID:0080438); autosomal dominant distal hereditary motor neuronopathy 11 (Disease Ontology:DOID:0081400)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030864 cortical actin cytoskeleton;GO:0042995 cell projection;GO:0033268 node of Ranvier", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0022011 myelination in peripheral nervous system;GO:0045162 clustering of voltage-gated sodium channels;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQW1-1", "uniprot_id": "A0A8M9PQW1_DANRE", "mass": 88205.0, "length": 789, "protein_name": "Probable ATP-dependent RNA helicase DDX20", "gene_name": "ddx20", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent RNA helicase DDX20 isoform 1", "refseq_ac": "NP_001116795", "gene_names_uniprotkb": "ddx20; fb59a11; gemin3; si:dkey-193l3.3; si:dkey-193l3.4; wu:fb16g08; wu:fb59a11", "gene_names_refseq": "ddx20; fb59a11; gemin3; si:dkey-193l3.3; si:dkey-193l3.4; wu:fb16g08; wu:fb59a11", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX20; 3.6.1.15; 3.6.4.13; DEAD box protein 20", "protein_names_refseq": "DEAD box protein 20; probable ATP-dependent RNA helicase DDX20 isoform 1; probable ATP-dependent RNA helicase DDX20", "tax_id": 7955, "disease": "", "pathway": " (dre:556273)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16109975;20047469;21168434;26469318;27189481;27880902;32218991", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.47257185.1, SRR32588734.1026219.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Jul 24, 2025 this sequence version replaced XP_068079068.1, XP_073765630.1, NP_001116795.1., [RefSeq]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0017111 ribonucleoside triphosphate phosphatase activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0042246 tissue regeneration;GO:0097421 liver regeneration;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M9PQW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PT64-1", "uniprot_id": "A0A8M9PT64_DANRE", "mass": 222904.0, "length": 1960, "protein_name": "Sodium channel protein", "gene_name": "scn8aa", "organism": "Zebrafish", "refseq_name": "sodium channel, voltage gated, type VIII, alpha subunit a isoform X2", "refseq_ac": "XP_068072895", "gene_names_uniprotkb": "scn8aa; Nav1.6; scn8a", "gene_names_refseq": "Nav1.6; scn8aa; scn8a", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "sodium channel, voltage gated, type VIII, alpha subunit a isoform X2", "tax_id": 7955, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); developmental and epileptic encephalopathy 13 (Disease Ontology:DOID:0080445); benign familial infantile seizures 5 (Disease Ontology:DOID:0081118); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0035725 sodium ion transmembrane transport;GO:0008045 motor neuron axon guidance;GO:0008345 larval locomotory behavior;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PT64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PU70-1", "uniprot_id": "A0A8M9PU70_DANRE", "mass": 75000.0, "length": 689, "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "slco1d1", "organism": "Zebrafish", "refseq_name": "solute carrier organic anion transporter family, member 1D1", "refseq_ac": "NP_001335015", "gene_names_uniprotkb": "slco1d1; slco1c; wu:fe36b05; zgc:163027", "gene_names_refseq": "slco1c; slco1d1; wu:fe36b05; zgc:163027", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member", "protein_names_refseq": "Oatp1d1; solute carrier anion transporting family member 1d1; solute carrier organic anion transporter family, member 1D1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); cholestasis (Disease Ontology:DOID:13580); colon carcinoma (Disease Ontology:DOID:1520); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (dre:326845)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19931635;24113777;24126916;25088042;26055554;32297059;34135935;34182632;34356784;34990119", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KP294314.1, GDQQ01008543.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Detailed characterization of a new Oatp transporter in zebrafish, offering important insights into the functional evolution of the OATP1/Oatp1 family and the physiological role of Oatp1d1., [RefSeq, PubMed]; Selective interaction of microcystin congeners with zebrafish (Danio rerio) Oatp1d1 transporter., [RefSeq, PubMed]; Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil., [RefSeq, PubMed]; Zebrafish Oatp1d1 offers new insights into the uptake processes of environmental contaminants., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J5F5;A0AC58J5H2", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:1905431 microcystin transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PU70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PX36-1", "uniprot_id": "A0A8M9PX36_DANRE", "mass": 40762.0, "length": 358, "protein_name": "2.4.3.8; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1", "gene_name": "st8sia7.1", "organism": "Zebrafish", "refseq_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1", "refseq_ac": "NP_001373444", "gene_names_uniprotkb": "st8sia7.1; siat 8G-r1", "gene_names_refseq": "siat 8G-r1; st8sia7.1", "protein_names_uniprotkb": "2.4.3.8; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1", "protein_names_refseq": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1; ST8Sia VIIA; alpha 2,8-sialyltransferase ST8Sia I/V/VI-r1", "tax_id": 7955, "disease": "", "pathway": " (dre:751830); (R-DRE-4085001); (R-DRE-975577)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18642128;18811928;22352757;30405127;30709055;34481069", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152017.1, GFIL01039912.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On or before Aug 29, 2020 this sequence version replaced XP_685638.4, XP_021329414.1., [RefSeq]; Study identified and characterized a new alpha2,8-sialyltransferase sequence in Danio rerio showing no transfer activity on sialylated fetuin. This sequence belongs to a new teleost mono-alpha2,8-sialyltransferase subfamily resulting from the second whole genome duplication event. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QXR5", "ec_number_list": "2.4.3.8", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M9PX36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T308-1", "uniprot_id": "RN168_DANRE", "mass": 53248.0, "length": 474, "protein_name": "E3 ubiquitin-protein ligase rnf168", "gene_name": "rnf168", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase rnf168", "refseq_ac": "NP_956149", "gene_names_uniprotkb": "rnf168; RNF168; fi30d02; wu:fi30d02; zgc:64185", "gene_names_refseq": "fi30d02; rnf168; wu:fi30d02; zgc:64185", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase rnf168", "protein_names_refseq": "E3 ubiquitin-protein ligase rnf168; RING-type E3 ubiquitin transferase rnf168", "tax_id": 7955, "disease": "RIDDLE syndrome (Disease Ontology:DOID:0090113)", "pathway": " (dre:334081); (R-DRE-3108214); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053301.1, EG582645.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505393 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053301.1., [RefSeq]; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.354;2.7.11.1;1.14.11.66;2.3.2.27;3.1.3.16;3.1.-.-;2.3.2.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T308-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q186-1", "uniprot_id": "A0A8M9Q186_DANRE", "mass": 201503.0, "length": 1812, "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "tet1", "organism": "Zebrafish", "refseq_name": "methylcytosine dioxygenase TET1 isoform X1", "refseq_ac": "XP_021328376", "gene_names_uniprotkb": "tet1", "gene_names_refseq": "tet1", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET; 1.14.11.80", "protein_names_refseq": "methylcytosine dioxygenase TET1 isoform X1", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:101883702)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021328376.1. COMPLETENESS: full length., [RefSeq]; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.80", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0070579 DNA 5-methylcytosine dioxygenase activity;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0001666 response to hypoxia;GO:0071222 cellular response to lipopolysaccharide;GO:0040029 epigenetic regulation of gene expression;GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q5V8-1", "uniprot_id": "A0A8M9Q5V8_DANRE", "mass": 68073.0, "length": 605, "protein_name": "Neuroepithelial cell-transforming gene 1 protein isoform X1", "gene_name": "net1", "organism": "Zebrafish", "refseq_name": "neuroepithelial cell-transforming gene 1 protein isoform X1", "refseq_ac": "XP_021330686", "gene_names_uniprotkb": "net1; wu:fb13g03; wu:fb25c11; zgc:92121", "gene_names_refseq": "net1; wu:fb13g03; wu:fb25c11; zgc:92121", "protein_names_uniprotkb": "Neuroepithelial cell-transforming gene 1 protein isoform X1", "protein_names_refseq": "neuroepithelial cell-transforming gene 1 protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0035025 positive regulation of Rho protein signal transduction;GO:1900107 regulation of nodal signaling pathway;GO:0009950 dorsal/ventral axis specification;GO:0048382 mesendoderm development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q5V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q653-1", "uniprot_id": "A0A8M9Q653_DANRE", "mass": 226394.0, "length": 1996, "protein_name": "Sodium channel protein", "gene_name": "scn1lab", "organism": "Zebrafish", "refseq_name": "sodium channel, voltage-gated, type I like, alpha b isoform X2", "refseq_ac": "XP_021332559", "gene_names_uniprotkb": "scn1lab", "gene_names_refseq": "scn1lab", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "sodium channel, voltage-gated, type I like, alpha b isoform X2", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); episodic ataxia type 9 (Disease Ontology:DOID:0060965); developmental and epileptic encephalopathy 6B (Disease Ontology:DOID:0070379); developmental and epileptic encephalopathy 62 (Disease Ontology:DOID:0080420); developmental and epileptic encephalopathy 11 (Disease Ontology:DOID:0080421); Dravet syndrome (Disease Ontology:DOID:0080422); benign familial infantile seizures 3 (Disease Ontology:DOID:0081116); familial focal epilepsy with variable foci 4 (Disease Ontology:DOID:0081424); familial hemiplegic migraine 3 (Disease Ontology:DOID:0111183); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dre:559447)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16615064;16830092;20339120;20484654;22880050;37572541;37769522;38474238;38667299;38707709", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JRM8", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0045202 synapse;GO:0001518 voltage-gated sodium channel complex;GO:0030424 axon", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0006110 regulation of glycolytic process;GO:0019228 neuronal action potential;GO:0034220 monoatomic ion transmembrane transport;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9Q653-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q7Y5-1", "uniprot_id": "A0A8M9Q7Y5_DANRE", "mass": 156023.0, "length": 1392, "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "si:ch73-383l1.1", "organism": "Zebrafish", "refseq_name": "receptor tyrosine-protein kinase erbB-4 isoform X1", "refseq_ac": "XP_021331611", "gene_names_uniprotkb": "si:ch73-383l1.1", "gene_names_refseq": "si:ch73-383l1.1", "protein_names_uniprotkb": "Receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "receptor tyrosine-protein kinase erbB-4 isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 19 (Disease Ontology:DOID:0060210); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:101885162)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005154 epidermal growth factor receptor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0012505 endomembrane system;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0030182 neuron differentiation;GO:0050679 positive regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q7Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q8E0-1", "uniprot_id": "A0A8M9Q8E0_DANRE", "mass": 58836.0, "length": 512, "protein_name": "Cholesterol side-chain cleavage enzyme, mitochondrial", "gene_name": "cyp11a1.2", "organism": "Zebrafish", "refseq_name": "cholesterol side-chain cleavage enzyme, mitochondrial", "refseq_ac": "XP_691817", "gene_names_uniprotkb": "cyp11a1.2", "gene_names_refseq": "cyp11a1.2", "protein_names_uniprotkb": "Cholesterol side-chain cleavage enzyme, mitochondrial; 1.14.15.6; Cholesterol desmolase", "protein_names_refseq": "cholesterol side-chain cleavage enzyme, mitochondrial", "tax_id": 7955, "disease": "congenital adrenal insufficiency (Disease Ontology:DOID:0050546); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); hypogonadism (Disease Ontology:DOID:1924); nephrosis (Disease Ontology:DOID:2527); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:563363)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.15.6", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008203 cholesterol metabolic process;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0006704 glucocorticoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q8E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q8Q6-1", "uniprot_id": "A0A8M9Q8Q6_DANRE", "mass": 35776.0, "length": 319, "protein_name": "V-set and transmembrane domain-containing protein 4", "gene_name": "vstm4b", "organism": "Zebrafish", "refseq_name": "V-set and transmembrane domain-containing protein 4", "refseq_ac": "XP_021335878", "gene_names_uniprotkb": "vstm4b", "gene_names_refseq": "vstm4b", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 4", "protein_names_refseq": "V-set and transmembrane domain-containing protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:100142652)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q8Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9QFE6-1", "uniprot_id": "A0A8M9QFE6_DANRE", "mass": 228810.0, "length": 1983, "protein_name": "Myosin-11a isoform X1", "gene_name": "myh11a", "organism": "Zebrafish", "refseq_name": "myosin-11a isoform X1", "refseq_ac": "XP_021332550", "gene_names_uniprotkb": "myh11a; myh11", "gene_names_refseq": "myh11a; myh11", "protein_names_uniprotkb": "Myosin-11a isoform X1", "protein_names_refseq": "myosin-11a isoform X1", "tax_id": 7955, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021332550.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005737 cytoplasm;GO:0016460 myosin II complex;GO:0032982 myosin filament", "go_biological_process": "GO:0008015 blood circulation;GO:0060047 heart contraction;GO:0048546 digestive tract morphogenesis;GO:0072593 reactive oxygen species metabolic process;GO:0030860 regulation of polarized epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9QFE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAK8-1", "uniprot_id": "TBX5A_DANRE", "mass": 55183.0, "length": 492, "protein_name": "T-box transcription factor TBX5-A", "gene_name": "tbx5a", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX5-A", "refseq_ac": "NP_001300611", "gene_names_uniprotkb": "tbx5a; heartstrings; hst; si:ch211-245e21.2; tbx5.1; tbx5", "gene_names_refseq": "hst; tbx5.1; tbx5a; tbx5", "protein_names_uniprotkb": "T-box transcription factor TBX5-A; T-box protein 5; zTbx5; zftbx5a", "protein_names_refseq": "T-box 5a; T-box gene 5.1; T-box protein 5; T-box transcription factor TBX5-A; T-box transcription factor TBX5; heartstrings", "tax_id": 7955, "disease": "Holt-Oram syndrome (Disease Ontology:DOID:0060468); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:30071); (R-DRE-2032785)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10495283;10640716;10664151;12223419;19925885;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF179407.1, SRR32588723.3745850.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters., [UniProtKB, UniProtKB, PubMed, PubMed]; The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JKS5;Q9PTK3;Q9PUS7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0000785 chromatin;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0060042 retina morphogenesis in camera-type eye;GO:0061026 cardiac muscle tissue regeneration;GO:0003342 proepicardium development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9IAK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9QDJ7-1", "uniprot_id": "A0A8M9QDJ7_DANRE", "mass": 77900.0, "length": 685, "protein_name": "Protein kinase C delta type", "gene_name": "prkcdb", "organism": "Zebrafish", "refseq_name": "protein kinase C, delta b", "refseq_ac": "NP_001352166", "gene_names_uniprotkb": "prkcdb; prkcd", "gene_names_refseq": "prkcdb; prkcd", "protein_names_uniprotkb": "Protein kinase C delta type; 2.7.11.13; nPKC-delta", "protein_names_refseq": "protein kinase C, delta b", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); muscular disease (Disease Ontology:DOID:0080000); autoimmune lymphoproliferative syndrome type 3 (Disease Ontology:DOID:0110119); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); restrictive cardiomyopathy (Disease Ontology:DOID:397); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100150844)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "26469318;26846883;27189481;30265984;30826544;34671015;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.618959.1, SRR26395013.1195734.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F4L5", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9QDJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHM9-1", "uniprot_id": "RHOAB_DANRE", "mass": 21863.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoA-B", "gene_name": "rhoab", "organism": "Zebrafish", "refseq_name": "rho-related GTP-binding protein RhoA-B", "refseq_ac": "NP_997914", "gene_names_uniprotkb": "rhoab; arha; rhoa; wu:fj42e08; zgc:153713; zgc:92206", "gene_names_refseq": "arha; rhoab; rhoa; wu:fj42e08; zgc:92206", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoA-B; 3.6.5.2", "protein_names_refseq": "rho-related GTP-binding protein RhoA-B; small GTPase RhoA", "tax_id": 7955, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100006041); (dre:751630)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15894457;16019189;23594743;26190758;27189481;35006271;35060996;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075938.1, BC152258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075938.1. On or before Jul 6, 2005 this sequence version replaced XP_699751.1, NP_997914.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction., [RefSeq, PubMed]; Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin alpha2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling., [RefSeq, PubMed]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results provide first evidence that RhoA in vivo acts downstream of Wnt5 and Wnt11 to effect, without affecting cell fates, the convergence and extension movements in zebrafish embryos; it elicits such effect via both effectors, Rho kinase and Dia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q52WZ2", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6DHM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8N6-1", "uniprot_id": "CSF1R_DANRE", "mass": 110188.0, "length": 977, "protein_name": "Macrophage colony-stimulating factor 1 receptor", "gene_name": "csf1ra; csf1r", "organism": "Zebrafish", "refseq_name": "macrophage colony-stimulating factor 1 receptor precursor", "refseq_ac": "NP_571747", "gene_names_uniprotkb": "csf1ra; csf1r; CSF-1R; M-CSF-R; csf1r; fms; panther", "gene_names_refseq": "CSF-1R; M-CSF-R; csf1ra; csf1r; fms; panther; si:zfos-1069f5.1", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1 receptor; 2.7.10.1; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms homolog", "protein_names_refseq": "CSF-1 receptor; CSF-1-R; c-fms; fms proto-oncogene homolog; macrophage colony-stimulating factor 1 receptor precursor; macrophage colony-stimulating factor 1 receptor; pfeffer; pfe; proto-oncogene c-Fms homolog; proto-oncogene fms homolog; salz; sal", "tax_id": 7955, "disease": "CSF1R-related brain malformation and osteopetrosis (Disease Ontology:DOID:0070343); bone development disease (Disease Ontology:DOID:0080006); colorectal carcinoma (Disease Ontology:DOID:0080199); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Disease Ontology:DOID:0080523); stomach cancer (Disease Ontology:DOID:10534); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); infertility (Disease Ontology:DOID:5223); lung small cell carcinoma (Disease Ontology:DOID:5409); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:64274); (R-DRE-449836)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10862741;12538511", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF240639.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF240639.1. On Jul 6, 2005 this sequence version replaced XP_689379.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that fms is not required for establishing a population of precursor cells during embryogenesis but is required for recruiting pigment cell precursors to xanthophore fates, with concomitant effects on melanophore organization., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Activates several signaling pathways in response to ligand binding (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005011 macrophage colony-stimulating factor receptor activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0019955 cytokine binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0036179 osteoclast maturation;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I8N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZE3-1", "uniprot_id": "L2GL2_DANRE", "mass": 113844.0, "length": 1020, "protein_name": "LLGL scribble cell polarity complex component 2", "gene_name": "llgl2", "organism": "Zebrafish", "refseq_name": "LLGL scribble cell polarity complex component 2", "refseq_ac": "NP_997747", "gene_names_uniprotkb": "llgl2; cb521; lgl2; llglh2; pen; sb:cb521; wu:fc06g08; wu:fl37c09; zgc:55895", "gene_names_refseq": "cb521; lgl2; llgl2; llglh2; sb:cb521; wu:fc06g08; wu:fl37c09; zgc:55895", "protein_names_uniprotkb": "LLGL scribble cell polarity complex component 2; Lethal(2) giant larvae protein homolog 2; Protein penner", "protein_names_refseq": "LLGL scribble cell polarity complex component 2; lethal giant larvae homolog 2; lethal(2) giant larvae protein homolog 2; protein penner", "tax_id": 7955, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dre:795670)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15983403;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC052919.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC052919.1. On Jul 6, 2005 this sequence version replaced XP_690777.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis., [UniProtKB, PubMed]; Lgl2 is necessary for hemidesmosome formation and maintenance of the tissue integrity in the developing basal epidermis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0098773 skin epidermis development;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0008285 negative regulation of cell population proliferation;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SZE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90416-1", "uniprot_id": "RXRGA_DANRE", "mass": 48720.0, "length": 441, "protein_name": "Retinoic acid receptor RXR-gamma-A", "gene_name": "rxrga", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rxrga; NR2B1; RXR; nr2b1; nr2b3a; rxra; rxrg; rxr", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma-A; Nuclear receptor subfamily 2 group B member 3-A; Retinoic acid receptor RXR-alpha; Retinoid X receptor alpha; Retinoid X receptor gamma-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (dre:30464)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15464576;15889082;16197547;16448862;17195188;33675800;34089732;36835354;37155312;38731293;7565671;9192646", "class_list": "", "function": "Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PBU9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q90416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DRD3-1", "uniprot_id": "DPOLB_DANRE", "mass": 38566.0, "length": 336, "protein_name": "DNA polymerase beta", "gene_name": "polb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "polb; wu:fa97a05; zgc:109924", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase beta; 2.7.7.7; 4.2.99.-; 4.2.99.18; 5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase", "protein_names_refseq": "", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:554204); (R-DRE-110362); (R-DRE-110373); (R-DRE-110381); (R-DRE-5649702); (R-DRE-5651801); (R-DRE-5689880); (R-DRE-73930)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "15256591;19374445;21172930;22018137;23720042;26469318;27189481;28645083;30500751;31024003;33120273;40044042", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB]; Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.99.18;5.6.2.4;2.7.1.78;3.1.3.32;2.7.7.7;2.7.7.31;3.1.11.2;3.1.21.-;6.5.1.1;3.2.1.143;2.7.7.49;3.6.4.12;3.2.2.-;2.7.7.102;2.4.2.-;2.4.2.30;4.2.99.-;3.1.-.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6DRD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DRB1-1", "uniprot_id": "GLE1_DANRE", "mass": 79128.0, "length": 695, "protein_name": "mRNA export factor GLE1", "gene_name": "gle1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gle1; gle1l", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA export factor GLE1; GLE1 RNA export mediator; GLE1-like protein; Nucleoporin GLE1", "protein_names_refseq": "", "tax_id": 7955, "disease": "lethal congenital contracture syndrome 1 (Disease Ontology:DOID:0060559)", "pathway": " (dre:445408); (R-DRE-159236)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15256591;22357925;25343993;26469318;26921650;27189481;28035044;30165106;32460013;36658633", "class_list": "", "function": "Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502U5", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0000822 inositol hexakisphosphate binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0044614 nuclear pore cytoplasmic filaments;GO:0005643 nuclear pore", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport;GO:0010842 retina layer formation;GO:0014037 Schwann cell differentiation;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6DRB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8JKM0-1", "uniprot_id": "B8JKM0_DANRE", "mass": 60047.0, "length": 524, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 1", "gene_name": "lrrtm1", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 1", "refseq_ac": "XP_005160139", "gene_names_uniprotkb": "lrrtm1", "gene_names_refseq": "lrrtm1", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 1", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:570385); (R-DRE-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B6X6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8JKM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWE3-1", "uniprot_id": "LARP7_DANRE", "mass": 64063.0, "length": 555, "protein_name": "La-related protein 7", "gene_name": "larp7", "organism": "Zebrafish", "refseq_name": "la-related protein 7", "refseq_ac": "NP_956224", "gene_names_uniprotkb": "larp7; fa10g04; wu:fa10g04; zgc:56476", "gene_names_refseq": "fa10g04; larp7; wu:fa10g04; zgc:56476", "protein_names_uniprotkb": "La-related protein 7; La ribonucleoprotein domain family member 7", "protein_names_refseq": "HDCMA18P protein; La ribonucleoprotein domain family, member 7; la-related protein 7", "tax_id": 7955, "disease": "", "pathway": " (dre:334956)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26542022", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049455.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049455.1., [RefSeq]; RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:26542022). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:26542022). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:26542022). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (By similarity). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (By similarity)., [UniProtKB, UniProtKB, PubMed]; The balance of Cdk9 and Larp7 plays a key role in cardiomyocyte proliferation and response to injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0097322 7SK snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0061026 cardiac muscle tissue regeneration;GO:1904871 positive regulation of protein localization to Cajal body;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZWE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90260-1", "uniprot_id": "ASL1B_DANRE", "mass": 22116.0, "length": 195, "protein_name": "Achaete-scute homolog 1b", "gene_name": "ascl1b", "organism": "Zebrafish", "refseq_name": "achaete-scute homolog 1b", "refseq_ac": "NP_571306", "gene_names_uniprotkb": "ascl1b; ashb; ash; si:ch211-210p4.6", "gene_names_refseq": "Zash-1b; ascl1b; ashb; ash; zashb", "protein_names_uniprotkb": "Achaete-scute homolog 1b; Zash-1b", "protein_names_refseq": "achaete scute homolog B; achaete-scute complex-like 1b; achaete-scute homolog 1b", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dre:30478)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15659486;16481349;37931393;7813774", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U14590.1, EH584585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U14590.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish., [RefSeq, PubMed]; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. May mediate transcription activation by binding to the E box-containing promoter., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802Y8-1", "uniprot_id": "ZB16A_DANRE", "mass": 74854.0, "length": 671, "protein_name": "Zinc finger and BTB domain-containing protein 16-A", "gene_name": "zbtb16a", "organism": "Zebrafish", "refseq_name": "zinc finger and BTB domain-containing protein 16-A", "refseq_ac": "NP_955929", "gene_names_uniprotkb": "zbtb16a; ZNF145; plzfa; wu:fb93g12; wu:fc07c10; zbtb16; zgc:55675", "gene_names_refseq": "ZNF145; wu:fb93g12; wu:fc07c10; zbtb16a; zbtb16; zgc:55675", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 16-A; Promyelocytic leukemia zinc finger protein-A; Zinc finger protein PLZF-A", "protein_names_refseq": "plzfa; promyelocytic leukemia zinc finger protein-A; zinc finger and BTB domain containing 16; zinc finger and BTB domain-containing protein 16-A; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)", "tax_id": 7955, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); caudal regression syndrome (Disease Ontology:DOID:0080700); polydactyly (Disease Ontology:DOID:1148)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "18307296;20080956;37642135", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046887.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046887.1. On Jul 6, 2005 this sequence version replaced XP_702059.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable transcription factor. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Inhibits neurogenesis., [UniProtKB, UniProtKB, PubMed]; Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0016567 protein ubiquitination;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q802Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV84-1", "uniprot_id": "DAAF1_DANRE", "mass": 62145.0, "length": 555, "protein_name": "Dynein axonemal assembly factor 1", "gene_name": "dnaaf1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dnaaf1; lrrc50; swt; zgc:56169", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal assembly factor 1; Leucine-rich repeat-containing protein 50", "protein_names_refseq": "", "tax_id": 7955, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 13 (Disease Ontology:DOID:0110618); seminoma (Disease Ontology:DOID:4440); testicular germ cell cancer (Disease Ontology:DOID:5557); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:386722)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;18178183;18385425;18784369;32196499;32307628;33251213;39095343;39388365;9334285", "class_list": "", "function": "Cilium-specific protein required for the stability of the ciliary architecture. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005930 axoneme;GO:0005929 cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003143 embryonic heart tube morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZV84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98864-1", "uniprot_id": "PTC1_DANRE", "mass": 135544.0, "length": 1220, "protein_name": "Protein patched homolog 1", "gene_name": "ptch1; ptch2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ptch1; ptch2; blowout; blw; etlD309849.2; ptc-1; ptc1; ptch1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein patched homolog 1; PTC1; Patched 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (dre:30181)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "36520654;36576487;36795618;38378191;39400299;8787757;9007226;9007259;9007260;9475747;9753672", "class_list": "", "function": "Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens. In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO. Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008158 hedgehog receptor activity;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048635 negative regulation of muscle organ development;GO:0061386 closure of optic fissure;GO:0009954 proximal/distal pattern formation;GO:0001649 osteoblast differentiation;GO:0010002 cardioblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q98864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1QHI8-1", "uniprot_id": "F1QHI8_DANRE", "mass": 41723.0, "length": 371, "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "pdgfrl", "organism": "Zebrafish", "refseq_name": "platelet-derived growth factor receptor-like protein precursor", "refseq_ac": "NP_956608", "gene_names_uniprotkb": "pdgfrl; zgc:56104; zgc:77677", "gene_names_refseq": "pdgfrl; zgc:56104; zgc:77677", "protein_names_uniprotkb": "Platelet-derived growth factor receptor-like protein", "protein_names_refseq": "platelet-derived growth factor receptor-like protein precursor", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:393284)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18296487;20802085;20935258;21909574;24608635;24683187;27189481;31597659;35088848;37024546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC062835.1, CU458959.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505380, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Jun 25, 2025 this sequence version replaced NP_956608.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PH05", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "F1QHI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T019-1", "uniprot_id": "DZIP1_DANRE", "mass": 101728.0, "length": 898, "protein_name": "Cilium assembly protein DZIP1", "gene_name": "dzip1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dzip1; dzip1; igu; si:dz52i16.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilium assembly protein DZIP1; DAZ-interacting protein 1 homolog; DAZ-interacting zinc finger protein 1; Iguana protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "spermatogenic failure 47 (Disease Ontology:DOID:0112175); coloboma (Disease Ontology:DOID:12270); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (dre:402875); (R-DRE-5632684)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10662647;11066087;15115751;15198976;19852954;23594743;32698004;34648325;35286359;38382674;38880277;9007259;9007260;9334285", "class_list": "", "function": "Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954). Required for establishment of left-right asymmetry during embryogenesis (PubMed:19852954). Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals (PubMed:15115751). Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo (PubMed:15198976)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QFL8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0140311 protein sequestering activity;GO:0062063 BBSome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005814 centriole;GO:0097730 non-motile cilium;GO:0034451 centriolar satellite", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0001568 blood vessel development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003143 embryonic heart tube morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7T019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R5J2-1", "uniprot_id": "DISP1_DANRE", "mass": 164535.0, "length": 1464, "protein_name": "Protein dispatched homolog 1", "gene_name": "disp1", "organism": "Zebrafish", "refseq_name": "protein dispatched homolog 1", "refseq_ac": "NP_997965", "gene_names_uniprotkb": "disp1; con; zgc:111866", "gene_names_refseq": "con; disp1; zgc:111866", "protein_names_uniprotkb": "Protein dispatched homolog 1; Protein chameleon", "protein_names_refseq": "dispatched 1; helix; hlx; protein chameleon; protein dispatched homolog 1", "tax_id": 7955, "disease": "", "pathway": " (dre:619201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15110707", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY512779.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY512779.1. On Dec 17, 2008 this sequence version replaced NP_001028765.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (PubMed:15110707). Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0008015 blood circulation;GO:0009887 animal organ morphogenesis;GO:0009952 anterior/posterior pattern specification;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6R5J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98SJ5-1", "uniprot_id": "SIM1A_DANRE", "mass": 82734.0, "length": 745, "protein_name": "Single-minded homolog 1-A", "gene_name": "sim1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "sim1a; sim1", "gene_names_refseq": "", "protein_names_uniprotkb": "Single-minded homolog 1-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:260351)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11493543;14718644;16109975;16574097;16691572;18330923;35104451;35623404;36063149;38017520;38253686", "class_list": "", "function": "Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021536 diencephalon development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007411 axon guidance;GO:0071542 dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q98SJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90481-1", "uniprot_id": "NX22A_DANRE", "mass": 30307.0, "length": 269, "protein_name": "Homeobox protein Nkx-2.2a", "gene_name": "nkx2.2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "nkx2.2a; id:ibd5090; nk2.2; nkx2-2; nkx2.2; wu:fc83b01; zgc:136536", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Nkx-2.2a; Homeobox protein NK-2 homolog B-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10223709;10331983;10906475;11239427;35623404;36065184;36810260;37529101;39251572;7600991;8787757", "class_list": "", "function": "Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021508 floor plate formation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0031018 endocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q90481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGE1-1", "uniprot_id": "MK14B_DANRE", "mass": 39998.0, "length": 348, "protein_name": "Mitogen-activated protein kinase 14B", "gene_name": "mapk14b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mapk14b; MAPK14; mapk14; p38b; zp38b", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 14B; 2.7.11.24; MAP kinase 14B; MAP kinase p38b; MAPK 14B; Mitogen-activated protein kinase p38b; zp38b", "protein_names_refseq": "", "tax_id": 7955, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); gastric adenocarcinoma (Disease Ontology:DOID:3717); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:266756); (R-DRE-168638); (R-DRE-171007); (R-DRE-198753); (R-DRE-2559580); (R-DRE-418592); (R-DRE-432142); (R-DRE-4420097); (R-DRE-450302); (R-DRE-450341); (R-DRE-525793); (R-DRE-5668599); (R-DRE-6798695); (R-DRE-6804756); (R-DRE-69601); (R-DRE-9824585)", "pathway_count": 16, "publication_count": 11, "publication_id_list": "10995439;15520368;16774848;20200220;20526952;21356182;31374495;31710851;35114580;35571926;36716661", "class_list": "", "function": "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.99.18;5.6.2.4;2.7.11.1;2.7.1.11;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;3.6.4.13;2.7.1.40;2.7.11.26;2.7.11.31;1.1.1.205;5.4.2.11;5.4.2.4;2.7.1.35;3.1.3.48;1.13.11.34;3.2.1.31;3.6.5.-;2.3.2.27;3.6.4.6;4.1.2.13;1.11.1.6", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:1901741 positive regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DGE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6KFX9-1", "uniprot_id": "RFNG_DANRE", "mass": 41019.0, "length": 362, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe", "gene_name": "rfng", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rfng; fd16f05; rfg; wu:fd16f05; zgc:136694", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "15068793;15376327;15659486;15797022;17507415;31273051;31502954;32094115;33771997;35675784", "class_list": "", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Regulates neurogenesis in the hindbrain; involved in boundary cell specification via Notch-mediated activation of wnt1 expression (PubMed:15068793, PubMed:15659486)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.222", "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0021592 fourth ventricle development;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation;GO:0030902 hindbrain development;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6KFX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q800Q5-1", "uniprot_id": "T7L1B_DANRE", "mass": 60418.0, "length": 551, "protein_name": "Transcription factor 7-like 1-B", "gene_name": "tcf7l1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tcf7l1b; TCF-3-B; tcf3b", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor 7-like 1-B; HMG box transcription factor 3-B; TCF-3-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30556)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12642497;15151990;15366005;15659486;16109975;17215296;28811218;28851992;29266316;30777146;35034853", "class_list": "", "function": "Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex;GO:0005634 nucleus", "go_biological_process": "GO:0021903 rostrocaudal neural tube patterning;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q800Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9E1-1", "uniprot_id": "FOXH1_DANRE", "mass": 51620.0, "length": 472, "protein_name": "Forkhead box protein H1", "gene_name": "foxh1", "organism": "Zebrafish", "refseq_name": "forkhead box protein H1", "refseq_ac": "NP_571577", "gene_names_uniprotkb": "foxh1; SUR; fast1; fast; fe26b06; schmalspur; sur; wu:fe26b06; wu:fi30c08; wu:fi32b01", "gene_names_refseq": "SUR; fast1; fast; fe26b06; foxh1; schmalspur; wu:fe26b06; wu:fi30c08; wu:fi32b01", "protein_names_uniprotkb": "Forkhead box protein H1; Fast-1; Forkhead activin signal transducer 1; Schmalspur protein", "protein_names_refseq": "etID62177.12; fast-1; forkhead activin signal transducer 1; forkhead box protein H1; uncle freddy; unf", "tax_id": 7955, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); agnathia-otocephaly complex (Disease Ontology:DOID:0060341)", "pathway": " (dre:57930)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10996071;10996072;11091091", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF263000.1, BC044340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708832, SAMEA898399 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF263000.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I8K6", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0001714 endodermal cell fate specification;GO:0007501 mesodermal cell fate specification;GO:0021508 floor plate formation;GO:0021501 prechordal plate formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9I9E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DI48-1", "uniprot_id": "DLLA_DANRE", "mass": 84969.0, "length": 772, "protein_name": "Delta-like protein A", "gene_name": "dla", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dla; cb335; fa04c10; wu:fa04c10", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta-like protein A; DeltaA", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:30131); (R-DRE-2979096)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10074451;10101116;10572043;10585570;10851132;12835391;15013799;15068793;15659486;18776899;37214246;37656795;38165177;38205258;38235293;9425132;9425133", "class_list": "", "function": "Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell fate. Plays a role in angiogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O57462", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0021536 diencephalon development;GO:0001525 angiogenesis;GO:0007219 Notch signaling pathway;GO:0014032 neural crest cell development;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6DI48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Y54-1", "uniprot_id": "JAG1B_DANRE", "mass": 133366.0, "length": 1213, "protein_name": "Protein jagged-1b", "gene_name": "jag1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "jag1b; jag3; kmi; puc; unp1069", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein jagged-1b; Jagged1b; Jagged3", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)", "pathway": " (dre:140423); (R-DRE-2979096); (R-DRE-9013149); (R-DRE-9013423)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15509774;15689380;15830385;15963491;16109975;37255715;38175750;38492873;38739706;39171526", "class_list": "", "function": "Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions., [UniProtKB]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0048752 semicircular canal morphogenesis;GO:0009913 epidermal cell differentiation;GO:0032474 otolith morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q90Y54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVS3-1", "uniprot_id": "PLK4_DANRE", "mass": 103485.0, "length": 940, "protein_name": "Serine/threonine-protein kinase PLK4", "gene_name": "plk4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "plk4; sak; stk18; wu:fi33g07", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK4; 2.7.11.21; PLK-4; Polo-like kinase 4; Serine/threonine-protein kinase Sak", "protein_names_refseq": "", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); microcephaly and chorioretinopathy 2 (Disease Ontology:DOID:0080106); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dre:368390); (R-DRE-380320)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16089502;20625580;23698347;24553125;24714733;25344692;26469318;26778655;32699963;32916112", "class_list": "", "function": "Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;3.1.3.16;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005814 centriole;GO:0098536 deuterosome", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0060271 cilium assembly;GO:0048589 developmental growth;GO:0098534 centriole assembly;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZVS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NW76-1", "uniprot_id": "AURKB_DANRE", "mass": 36947.0, "length": 320, "protein_name": "Aurora kinase B", "gene_name": "aurkb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "aurkb; CHUNP6896; aurB; cei; fa09g06; fd02h12; stka; wu:fa09g06; wu:fd02h12", "gene_names_refseq": "", "protein_names_uniprotkb": "Aurora kinase B; 2.7.11.1; Serine/threonine kinase A; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "spermatogenic failure 5 (Disease Ontology:DOID:0070183); brain cancer (Disease Ontology:DOID:1319); endometrial carcinoma (Disease Ontology:DOID:2871); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:791894); (R-DRE-141430); (R-DRE-141444); (R-DRE-174178); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220); (R-DRE-6804756)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "12006978;15476560;18510930;19543364;19850031;32367800;34882480;37898820;38850245;38960037", "class_list": "", "function": "Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (By similarity). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (By similarity). Required for central/midzone spindle assembly and cleavage furrow formation (By similarity). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage (By similarity). Phosphorylates 'Ser-10' of histone H3 during mitosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JGS8", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;3.1.3.16;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;3.6.4.12;2.7.11.31;2.3.2.23", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0000776 kinetochore", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0043687 post-translational protein modification;GO:0000281 mitotic cytokinesis;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6NW76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU13-1", "uniprot_id": "SPNS1_DANRE", "mass": 54981.0, "length": 506, "protein_name": "Protein spinster homolog 1", "gene_name": "spns1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "spns1; etID64740.3; nrs; spinl; wu:fb95b12; wu:fi37e11", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein spinster homolog 1; Protein not really started; Spinster-like protein; Spns1", "protein_names_refseq": "", "tax_id": 7955, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (dre:799873)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11836794;16109975;18704191;24967584;27189481;27875093;28878041;33277797;36161949", "class_list": "", "function": "Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids (PubMed:36161949). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) (PubMed:36161949). Essential player in lysosomal homeostasis (PubMed:27875093). Critical for embryogenesis (PubMed:11836794, PubMed:18704191). Involved in the regulation of developmental senescence (PubMed:27875093)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8UVB7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006869 lipid transport;GO:0006914 autophagy;GO:0090398 cellular senescence", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7ZU13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYL3-1", "uniprot_id": "SIAH2_DANRE", "mass": 34494.0, "length": 331, "protein_name": "E3 ubiquitin-protein ligase Siah2", "gene_name": "siah2l", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "siah2l; siah2; siaz; zgc:66284", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Siah2; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH2; Seven in absentia homolog 2-like; Siah-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:378728); (R-DRE-5689880); (R-DRE-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12915316;15055544;15922293;23261508;24823357;26469318;31189662;33330480", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHZ9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7SYL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DGB6-1", "uniprot_id": "DAA19_DANRE", "mass": 27594.0, "length": 247, "protein_name": "Dynein axonemal assembly factor 19", "gene_name": "dnaaf19", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dnaaf19; ccdc103; smh; zgc:100838", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal assembly factor 19; Coiled-coil domain-containing protein 103; Protein schmalhans", "protein_names_refseq": "", "tax_id": 7955, "disease": "primary ciliary dyskinesia 17 (Disease Ontology:DOID:0110621); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:437026)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22581229", "class_list": "", "function": "Dynein-attachment factor required for cilia motility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036157 outer dynein arm", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003143 embryonic heart tube morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DGB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DGD3-1", "uniprot_id": "SV91A_DANRE", "mass": 47471.0, "length": 411, "protein_name": "Histone-lysine N-methyltransferase SUV39H1-A", "gene_name": "suv39h1a", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase SUV39H1-A", "refseq_ac": "NP_001003592", "gene_names_uniprotkb": "suv39h1a; fe02c04; si:dkey-16n15.2; suv39h1; wu:fe02c04; zgc:101027", "gene_names_refseq": "fe02c04; suv39h1a; suv39h1; wu:fe02c04; zgc:101027", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H1-A; 2.1.1.-; Su(var)3-9 homolog 1-A; Suppressor of variegation 3-9 homolog 1-A", "protein_names_refseq": "histone-lysine N-methyltransferase SUV39H1-A; su(var)3-9 homolog 1-A; suppressor of variegation 3-9 homolog 1-A; suppressor of variegation 3-9 homolog 1a; suppressor of variegation 3-9-like 1a", "tax_id": 7955, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071)", "pathway": " (dre:445198); (R-DRE-3214841)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16980612;18231586;23594743;23705022", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMN06645146 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076417.1. On or before Jul 6, 2005 this sequence version replaced XP_709770.1, XP_683749.1., [RefSeq]; Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development., [UniProtKB, PubMed]; The identification of a histone H3 lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5XBP4;B0S580", "ec_number_list": "2.1.1.-;2.1.1.366;2.1.1.354", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0140258 histone H3K14ub reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0060042 retina morphogenesis in camera-type eye;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DGD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DGH9-1", "uniprot_id": "OTBP_DANRE", "mass": 34028.0, "length": 315, "protein_name": "Homeobox protein orthopedia B", "gene_name": "otpb", "organism": "Zebrafish", "refseq_name": "homeobox protein orthopedia B isoform 1", "refseq_ac": "NP_571175", "gene_names_uniprotkb": "otpb; cb977; otp1; otpa; otp", "gene_names_refseq": "cb977; otp1; otpb; otp", "protein_names_uniprotkb": "Homeobox protein orthopedia B", "protein_names_refseq": "homeobox protein orthopedia B isoform 1; homeobox protein orthopedia B; orthopedia homolog b; orthopedia protein; otp a", "tax_id": 7955, "disease": "", "pathway": " (dre:30316)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17074092;17180684;17481897", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF071496.2, GFIL01029230.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476815 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum., [UniProtKB, PubMed, PubMed]; Orthopedia is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system. Erratum:[Curr Biol. 2008 Feb 26;18(4):310], [RefSeq, PubMed]; Otp1 transcription factor is important for regulation of diencephalon development and early neuronal progenitors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W7M5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042552 myelination;GO:0007420 brain development;GO:0030182 neuron differentiation;GO:0021854 hypothalamus development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DGH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHC1-1", "uniprot_id": "RB18B_DANRE", "mass": 23013.0, "length": 205, "protein_name": "Ras-related protein Rab-18-B", "gene_name": "rab18b", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-18-B", "refseq_ac": "NP_001003449", "gene_names_uniprotkb": "rab18b; rab18; zgc:92523", "gene_names_refseq": "rab18b; zgc:92523", "protein_names_uniprotkb": "Ras-related protein Rab-18-B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-18-B", "tax_id": 7955, "disease": "Warburg micro syndrome 3 (Disease Ontology:DOID:0110718)", "pathway": " (dre:445055); (R-DRE-6798695); (R-DRE-8873719)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21473985;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076054.1, EH437654.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076054.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007420 brain development;GO:0034389 lipid droplet organization;GO:0001654 eye development;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DHC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHF9-1", "uniprot_id": "SIX1A_DANRE", "mass": 31928.0, "length": 283, "protein_name": "Homeobox protein six1a", "gene_name": "six1a", "organism": "Zebrafish", "refseq_name": "homeobox protein six1a", "refseq_ac": "NP_001009904", "gene_names_uniprotkb": "six1a; six1b", "gene_names_refseq": "six1a; six1b; six2; zgc:92332", "protein_names_uniprotkb": "Homeobox protein six1a; Homeobox protein six1b; Sine oculis homeobox homolog 1a; Sine oculis homeobox homolog 1b", "protein_names_refseq": "homeobox protein six1a; homeobox protein six1b; homeodomain transcription factor Six1b; sine oculis homeobox homolog 1a; sine oculis homeobox homolog 1b; sine oculis homeobox homolog 2", "tax_id": 7955, "disease": "branchiootic syndrome 3 (Disease Ontology:DOID:0061210); autosomal dominant nonsyndromic deafness 23 (Disease Ontology:DOID:0110553); branchiootorenal syndrome (Disease Ontology:DOID:14702); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); neurilemmoma (Disease Ontology:DOID:3192); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:494168)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18789916;19409884;23444384;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076015.1, EH451622.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076015.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Six1a and pax3 do not function in the same regulatory network. We proposed four putative regulatory pathways to understand how six1a distinctly interacts with either myf5 or myod during zebrafish craniofacial muscle development., [RefSeq, PubMed]; Six1a plays an essential role at the onset of fast muscle differentiation., [RefSeq, PubMed]; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as a transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A5G7", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0048741 skeletal muscle fiber development;GO:0014857 regulation of skeletal muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DHF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHI1-1", "uniprot_id": "ZDHC7_DANRE", "mass": 34191.0, "length": 299, "protein_name": "Palmitoyltransferase ZDHHC7", "gene_name": "zdhhc7", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC7", "refseq_ac": "NP_001002602", "gene_names_uniprotkb": "zdhhc7; dhhc7; zgc:92305", "gene_names_refseq": "zdhhc7; zgc:92305", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC7; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC7; Zinc finger DHHC domain-containing protein 7", "protein_names_refseq": "acyltransferase ZDHHC7; palmitoyltransferase ZDHHC7; zinc finger DHHC domain-containing protein 7; zinc finger DHHC-type containing 7; zinc finger DHHC-type palmitoyltransferase 7", "tax_id": 7955, "disease": "", "pathway": " (dre:436875); (R-DRE-9009391)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23594743;26056731;27235108;28167757", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075993.1, EH456609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075993.1., [RefSeq]; Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity;GO:0016417 S-acyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:1903076 regulation of protein localization to plasma membrane;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DHI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHI5-1", "uniprot_id": "SIR5_DANRE", "mass": 33929.0, "length": 305, "protein_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "gene_name": "sirt5", "organism": "Zebrafish", "refseq_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "refseq_ac": "NP_001002605", "gene_names_uniprotkb": "sirt5; si:ch211-121a2.1", "gene_names_refseq": "sirt5; zgc:92288", "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-5, mitochondrial; 2.3.1.-; Regulatory protein SIR2 homolog 5", "protein_names_refseq": "NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial", "tax_id": 7955, "disease": "", "pathway": " (dre:436878); (R-DRE-2151201)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075987.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075987.1. On or before Jul 6, 2005 this sequence version replaced XP_688084.1, XP_709038.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0036054 protein-malonyllysine demalonylase activity;GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0008270 zinc ion binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0010566 regulation of ketone biosynthetic process;GO:0036047 peptidyl-lysine demalonylation;GO:0036048 protein desuccinylation;GO:0036049 peptidyl-lysine desuccinylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DHI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DHR8-1", "uniprot_id": "NGBR_DANRE", "mass": 31276.0, "length": 274, "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit nus1", "gene_name": "nus1", "organism": "Zebrafish", "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit nus1", "refseq_ac": "NP_001002356", "gene_names_uniprotkb": "nus1; ngbr; si:ch211-102b16.1; zgc:92136", "gene_names_refseq": "fc21g03; nus1; wu:fc21g03; zgc:92136", "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit nus1; 2.5.1.87; Di-trans,poly-cis-decaprenylcistransferase; NgBR; Nogo-B receptor; Nuclear undecaprenyl pyrophosphate synthase 1 homolog", "protein_names_refseq": "dehydrodolichyl diphosphate syntase complex subunit nus1; dehydrodolichyl diphosphate synthase complex subunit nus1; di-trans,poly-cis-decaprenylcistransferase; ngBR; nogo-B receptor", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 55 (Disease Ontology:DOID:0080227); congenital disorder of glycosylation Iaa (Disease Ontology:DOID:0080553); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (dre:436629); (R-DRE-446199)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20813898;23594743;39561044", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075899.1, EG577779.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075899.1., [RefSeq]; Functional role for Nogo-B and its receptor (NgBR) in angiogenesis, [RefSeq, PubMed]; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V3G6;B0V3G7", "ec_number_list": "2.5.1.87", "go_molecular_function": "GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0032367 intracellular cholesterol transport;GO:0002040 sprouting angiogenesis;GO:0036269 swimming behavior;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6DHR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DRC0-1", "uniprot_id": "SYSC_DANRE", "mass": 58718.0, "length": 515, "protein_name": "Serine--tRNA ligase, cytoplasmic", "gene_name": "sars1", "organism": "Zebrafish", "refseq_name": "serine--tRNA ligase, cytoplasmic", "refseq_ac": "NP_001003882", "gene_names_uniprotkb": "sars1; sars", "gene_names_refseq": "SerRS; sars1; sars; wu:fk51f08; zgc:92152", "protein_names_uniprotkb": "Serine--tRNA ligase, cytoplasmic; 6.1.1.11; SerRS; Seryl-tRNA synthetase", "protein_names_refseq": "adrasteia; serine--tRNA ligase, cytoplasmic; unm s277; unm_s277", "tax_id": 7955, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate carcinoma (Disease Ontology:DOID:10286); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:445405)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15256591;19423847;19423848;22353712;23594743;24940000;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081608.1, AY648839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:19423848). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:19423848). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc (PubMed:24940000). Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa (PubMed:19423847, PubMed:19423848, PubMed:22353712, PubMed:24940000)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; SARS regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. Erratum:[Circ Res. 2009 Oct 23;105(9):e54], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004828 serine-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0061300 cerebellum vasculature development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0016525 negative regulation of angiogenesis;GO:0001569 branching involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6DRC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DRP4-1", "uniprot_id": "CCM2_DANRE", "mass": 49827.0, "length": 455, "protein_name": "Cerebral cavernous malformations protein 2 homolog", "gene_name": "ccm2", "organism": "Zebrafish", "refseq_name": "cerebral cavernous malformations protein 2 homolog", "refseq_ac": "NP_001002315", "gene_names_uniprotkb": "ccm2; TUF2; vtn; zgc:110233", "gene_names_refseq": "TUF2; ccm2; vtn; zgc:110233", "protein_names_uniprotkb": "Cerebral cavernous malformations protein 2 homolog; Malcavernin; Valentine", "protein_names_refseq": "cerebral cavernous malformation 2; cerebral cavernous malformations protein 2 homolog; malcavernin; valentine", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 2 (Disease Ontology:DOID:0060670)", "pathway": " (dre:436586)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15256591;16873582;19151727", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ677878.1, AY648715.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Sep 27, 2016 this sequence version replaced XP_005160514.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity)., [UniProtKB, PubMed]; Zebrafish embryos with the recessive lethal mutations santa (san) and valentine (vtn) do not thicken, but do add the proper number of cells to the myocardium., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0Z802;Q568L2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007507 heart development;GO:0060047 heart contraction;GO:0007043 cell-cell junction assembly;GO:0009948 anterior/posterior axis specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DRP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6EIG3-1", "uniprot_id": "CP26B_DANRE", "mass": 57598.0, "length": 511, "protein_name": "Cytochrome P450 26B1", "gene_name": "cyp26b1", "organism": "Zebrafish", "refseq_name": "cytochrome P450 26B1", "refseq_ac": "NP_997831", "gene_names_uniprotkb": "cyp26b1", "gene_names_refseq": "cyp26b1; fc21d03; wu:fc21d03; wu:fc26h10; zgc:76999", "protein_names_uniprotkb": "Cytochrome P450 26B1; 1.14.13.-; Cyp26B1; Retinoic acid-metabolizing cytochrome", "protein_names_refseq": "cytochrome P450 26B1; dol; retinoic acid-metabolizing cytochrome; stocksteif", "tax_id": 7955, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:324188); (R-DRE-211916); (R-DRE-5365859)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15661642;22019272", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066759.1, EE111284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:15661642). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Cyp26b1 is involved in limiting the activity of retinoic acid. Zygotic cyp26b1 was localized to presumptive rhombomere 3 and rhombomere 4 at early two-somite (2S) stage. Expression expands anteriorly to include rhombomere 2 at the 10S stage., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NY30", "ec_number_list": "1.14.13.-", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0062183 all-trans retinoic acid 18-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060323 head morphogenesis;GO:0060365 coronal suture morphogenesis;GO:0007417 central nervous system development;GO:0042573 retinoic acid metabolic process;GO:0030902 hindbrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6EIG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6EJB7-1", "uniprot_id": "SOX3_DANRE", "mass": 33417.0, "length": 300, "protein_name": "Transcription factor Sox-3", "gene_name": "sox3", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-3", "refseq_ac": "NP_001001811", "gene_names_uniprotkb": "sox3; zgc:110279", "gene_names_refseq": "id:ibd2036; sb:cb493; sox3; wu:fd02a08; zgc:110279", "protein_names_uniprotkb": "Transcription factor Sox-3", "protein_names_refseq": "SRY (sex determining region Y)-box 3; SRY-box containing gene 3; transcription factor SOX3; transcription factor Sox-3", "tax_id": 7955, "disease": "X-linked panhypopituitarism (Disease Ontology:DOID:0111779); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:30529); (R-DRE-3769402)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15262889;15532058;16408288;18307296;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092845.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092845.1. On Jan 18, 2006 this sequence version replaced NP_001001811.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q762C1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6EJB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6EWH2-1", "uniprot_id": "FYNA_DANRE", "mass": 60569.0, "length": 537, "protein_name": "Tyrosine-protein kinase fyna", "gene_name": "fyna", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase fyna", "refseq_ac": "NP_001315092", "gene_names_uniprotkb": "fyna; fyn", "gene_names_refseq": "c-fyn; fyna; fyn; zgc:86720", "protein_names_uniprotkb": "Tyrosine-protein kinase fyna; 2.7.10.2; Proto-oncogene c-Fyna", "protein_names_refseq": "FYN oncogene related to SRC, FGR, YES a; proto-oncogene c-Fyna; tyrosine-protein kinase fyna", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); Goldenhar syndrome (Disease Ontology:DOID:2907); skin squamous cell carcinoma (Disease Ontology:DOID:3151); temporal lobe epilepsy (Disease Ontology:DOID:3328); skin disease (Disease Ontology:DOID:37); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:373872)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10993948;15572145;15815683;16112104;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ620748.1, GDQQ01039198.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jun 8, 2016 this sequence version replaced XP_005169873.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling., [UniProtKB, UniProtKB, PubMed, PubMed]; Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8W4M2;Q58HR4;Q6DI27;Q9I8J8", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0042552 myelination;GO:0050852 T cell receptor signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6EWH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GMI9-1", "uniprot_id": "UXS1_DANRE", "mass": 47676.0, "length": 418, "protein_name": "UDP-glucuronic acid decarboxylase 1", "gene_name": "uxs1", "organism": "Zebrafish", "refseq_name": "UDP-glucuronic acid decarboxylase 1", "refseq_ac": "NP_775349", "gene_names_uniprotkb": "uxs1; zgc:91980", "gene_names_refseq": "CHUNP6891; fj36b08; uxs1; wu:fj36b08; zgc:91980", "protein_names_uniprotkb": "UDP-glucuronic acid decarboxylase 1; 4.1.1.35; UDP-glucuronate decarboxylase 1; UXS-1", "protein_names_refseq": "UDP-glucuronic acid decarboxylase 1; UXS-1", "tax_id": 7955, "disease": "", "pathway": " (dre:192315); (R-DRE-173599); (R-DRE-1971475)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12006978;16759393;20226781;22869369", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074058.1, GDQH01002528.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 13, 2015 this sequence version replaced NP_775349.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of chondroitin sulfate and heparan sulfate biosynthesis in zebrafish larvae homozygous for mutations in ext2, extl3, uxs1, or b3gat3, [RefSeq, PubMed]; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:20226781). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:20226781). Catalyzes the synthesis of UDP-xylose in two steps: the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket (By similarity). In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form (By similarity). Essential during embryogenesis for craniofacial development (PubMed:12006978, PubMed:16759393, PubMed:20226781)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; These results show that uxs1 transcript is localized in a pattern consistent with the mutant craniofacial phenotype, and that transcript instability may contribute to the loss of uxs1 function in uxs1hi3357 larvae., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHG1", "ec_number_list": "4.1.1.35", "go_molecular_function": "GO:0070403 NAD+ binding;GO:0048040 UDP-glucuronate decarboxylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0042732 D-xylose metabolic process;GO:0030198 extracellular matrix organization;GO:0001503 ossification;GO:0006024 glycosaminoglycan biosynthetic process;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6GMI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GMK0-1", "uniprot_id": "MGT4B_DANRE", "mass": 62991.0, "length": 547, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B", "gene_name": "mgat4bQ9UQ53", "organism": "Zebrafish", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B", "refseq_ac": "NP_001002180", "gene_names_uniprotkb": "mgat4bQ9UQ53; zgc:92425", "gene_names_refseq": "mgat4bQ9UQ53; mgat4b; wu:fc25g12; zgc:92425", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; 2.4.1.145; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb", "protein_names_refseq": "N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; glcNAc-T IVb; gnT-IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B", "tax_id": 7955, "disease": "", "pathway": " (dre:431727); (R-DRE-975577)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC074045.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC074045.1., [RefSeq]; Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Prefers complex-type N-glycans over hybrid-types. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.145", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GMK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQN0-1", "uniprot_id": "CEP41_DANRE", "mass": 41425.0, "length": 374, "protein_name": "Centrosomal protein of 41 kDa", "gene_name": "cep41", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 41 kDa", "refseq_ac": "NP_001002194", "gene_names_uniprotkb": "cep41; tsga14; zgc:91859", "gene_names_refseq": "cep41; tsga14; zgc:91859", "protein_names_uniprotkb": "Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein", "protein_names_refseq": "centrosomal protein of 41 kDa; testis specific, 14; testis-specific gene A14 protein", "tax_id": 7955, "disease": "Joubert syndrome 15 (Disease Ontology:DOID:0110984)", "pathway": " (dre:431741); (R-DRE-380320)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22246503;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC072712.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476746, SAMEA4476759 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072712.1., [RefSeq]; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0001525 angiogenesis;GO:0015031 protein transport;GO:0001755 neural crest cell migration;GO:0060271 cilium assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6GQN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IVV8-1", "uniprot_id": "PKD2_DANRE", "mass": 103269.0, "length": 904, "protein_name": "Polycystin-2", "gene_name": "pkd2", "organism": "Zebrafish", "refseq_name": "polycystin-2", "refseq_ac": "NP_001002310", "gene_names_uniprotkb": "pkd2", "gene_names_refseq": "pkd2", "protein_names_uniprotkb": "Polycystin-2; Cup; Curly up; Polycystic kidney disease 2 protein homolog; Transient receptor potential cation channel subfamily P member 2", "protein_names_refseq": "TRPP2; cup; curly up; polycystic kidney disease 2 protein homolog; polycystin-2; transient receptor potential cation channel subfamily P member 2", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 2 (Disease Ontology:DOID:0110859); intracranial aneurysm (Disease Ontology:DOID:10941); acute kidney failure (Disease Ontology:DOID:3021); retinal degeneration (Disease Ontology:DOID:8466); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (R-DRE-5620916)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15269167;15563610;16216239;16551655;16943304;17360770;23376035;23594743;25660539;26432887;35835458", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY618926.1, DQ175629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY618926.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Atp-2, lov-1, and pkd2 act in the same molecular pathway., [RefSeq, PubMed]; Forms a nonselective cation channel. Can function as a homotetrameric ion channel or can form heteromer with PKD1. Displays distinct function depending on its subcellular localization and regulation by its binding partners. In the primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (Probable). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades (PubMed:25660539). Required for normal temporal variation of the intracellular Ca(2+) levels in the heart (PubMed:23376035). Plays a role in fluid-flow mechanosensation (By similarity). Required for normal specification of the body left-right axis during embryogenesis, most likely via its role in ciliary Ca(2+) oscillations in Kupffer's vesicle (By similarity) (PubMed:15269167, PubMed:16216239, PubMed:16943304, PubMed:17360770, PubMed:23376035, PubMed:25660539)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; The functions of polaris and pkd2 in LR patterning are conserved between zebrafish and mice and that Kupffer's vesicle, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2VF27", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0015271 outward rectifier potassium channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0003171 atrioventricular valve development;GO:0051284 positive regulation of sequestering of calcium ion;GO:0007166 cell surface receptor signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6IVV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IVW0-1", "uniprot_id": "IFT57_DANRE", "mass": 46593.0, "length": 407, "protein_name": "Intraflagellar transport protein 57 homolog", "gene_name": "ift57", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 57 homolog", "refseq_ac": "NP_001001832", "gene_names_uniprotkb": "ift57", "gene_names_refseq": "hippi; ift57; zgc:111831", "protein_names_uniprotkb": "Intraflagellar transport protein 57 homolog", "protein_names_refseq": "axonemal transport protein; curly; intraflagellar transport protein 57 homolog", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); orofaciodigital syndrome XVIII (Disease Ontology:DOID:0060961)", "pathway": " (dre:414929); (R-DRE-5610787)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15182712;15269167;15790966;18056639", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY618924.1, BC095565.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY618924.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro-apoptotic function., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q502T5;Q56HB0;Q6J504", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006915 apoptotic process;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IVW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IWL4-1", "uniprot_id": "TRAF6_DANRE", "mass": 61806.0, "length": 542, "protein_name": "TNF receptor-associated factor 6", "gene_name": "traf6", "organism": "Zebrafish", "refseq_name": "TNF receptor-associated factor 6", "refseq_ac": "NP_001038217", "gene_names_uniprotkb": "traf6; fi15f02; si:dkey-56p7.3; wu:fi15f02; zgc:63704", "gene_names_refseq": "fi15f02; traf6; wu:fi15f02; zgc:63704", "protein_names_uniprotkb": "TNF receptor-associated factor 6; 2.3.2.27; E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6", "protein_names_refseq": "E3 ubiquitin-protein ligase TRAF6; RING-type E3 ubiquitin transferase TRAF6; TNF receptor-associated factor 6", "tax_id": 7955, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); laryngeal carcinoma (Disease Ontology:DOID:2600)", "pathway": " (dre:554561); (R-DRE-168638); (R-DRE-209543); (R-DRE-209560); (R-DRE-445989); (R-DRE-450302); (R-DRE-450321); (R-DRE-5689880); (R-DRE-5689896); (R-DRE-9020702); (R-DRE-937039); (R-DRE-937042); (R-DRE-937072); (R-DRE-975144); (R-DRE-975163)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "15829296;23594743;38861111", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055214.1, SRR5865381.33699.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On or before Apr 17, 2008 this sequence version replaced NP_956115.1, XP_702124.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation., [UniProtKB, UniProtKB]; Full-length traf6 was functionally characterized., [RefSeq, PubMed]; The New Roles of traf6 Gene Involved in the Development of Zebrafish Liver and Gonads., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1MTB3;Q7SXX1", "ec_number_list": "2.3.2.27;2.7.11.10;2.7.11.25;3.4.19.12;3.6.5.2;2.7.11.13;2.7.12.2", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0035591 signaling adaptor activity;GO:0004842 ubiquitin-protein transferase activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005938 cell cortex", "go_biological_process": "GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0009615 response to virus;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6IWL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NSN2-1", "uniprot_id": "AOF_DANRE", "mass": 58765.0, "length": 522, "protein_name": "Amine oxidase [flavin-containing]", "gene_name": "mao", "organism": "Zebrafish", "refseq_name": "amine oxidase [flavin-containing]", "refseq_ac": "NP_997992", "gene_names_uniprotkb": "mao; zgc:85761", "gene_names_refseq": "Z-MAO; maob; mao; moa; wu:fb68b05; wu:fo76d11; wu:fq38g06; zgc:85761", "protein_names_uniprotkb": "Amine oxidase [flavin-containing]; 1.4.3.21; 1.4.3.4; MAO; Monoamine oxidase; Z-MAO", "protein_names_refseq": "amine oxidase [flavin-containing]; amine oxidase", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Brunner Syndrome (Disease Ontology:DOID:0060693); Alzheimer's disease (Disease Ontology:DOID:10652); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); panic disorder (Disease Ontology:DOID:594)", "pathway": " (dre:404730); (R-DRE-141333); (R-DRE-181430); (R-DRE-379397); (R-DRE-379398); (R-DRE-379401); (R-DRE-380612)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "15621520;16917825", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC070013.1, GFIL01025783.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On May 24, 2004 this sequence version replaced NP_997992.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:15621520, PubMed:16917825). Preferentially oxidizes serotonin and tyramine (PubMed:15621520, PubMed:16917825). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This study confirm the presence of functionally active MAO in zebrafish brain and other tissues and characterize the neural systems that express MAO and areas of intense activity in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q804D6", "ec_number_list": "1.4.3.-;1.4.3.4;1.4.3.21", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0001964 startle response;GO:0042428 serotonin metabolic process;GO:0035176 social behavior;GO:0006584 catecholamine metabolic process;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NSN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NSN5-1", "uniprot_id": "PURA1_DANRE", "mass": 50374.0, "length": 456, "protein_name": "Adenylosuccinate synthetase isozyme 1", "gene_name": "adss1", "organism": "Zebrafish", "refseq_name": "adenylosuccinate synthetase isozyme 1", "refseq_ac": "NP_999985", "gene_names_uniprotkb": "adss1; adssl1; zgc:85738", "gene_names_refseq": "AdSS 1; adss1; adssl1; zgc:85738", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 1; 6.3.4.4; AMPSase 1; AdSS 1; Adenylosuccinate synthetase, basic isozyme; Adenylosuccinate synthetase, muscle isozyme; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase", "protein_names_refseq": "adenylosuccinate synthase like 1; adenylosuccinate synthetase isozyme 1", "tax_id": 7955, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (dre:407989); (R-DRE-73817)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18307296;26506222", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC070009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070009.1., [RefSeq]; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.4.4", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046716 muscle cell cellular homeostasis;GO:0046040 IMP metabolic process;GO:0048741 skeletal muscle fiber development;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NSN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NW58-1", "uniprot_id": "SPAST_DANRE", "mass": 63086.0, "length": 570, "protein_name": "Spastin", "gene_name": "spast", "organism": "Zebrafish", "refseq_name": "spastin", "refseq_ac": "NP_998080", "gene_names_uniprotkb": "spast; SPAST; SPG4; si:ch73-233a22.3; spg4; zgc:85952", "gene_names_refseq": "spast; spg4; zgc:85952", "protein_names_uniprotkb": "Spastin; 5.6.1.1", "protein_names_refseq": "spastin", "tax_id": 7955, "disease": "hereditary spastic paraplegia 4 (Disease Ontology:DOID:0110792); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:405851); (R-DRE-9668328)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16893913;20829563;22573551;23594743;26744324;30082270", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY304504.1, BC067715.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY304504.1 and JBMGRA010000001.1. On Oct 9, 2016 this sequence version replaced NP_998080.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches., [UniProtKB, HAMAP, UniProtKB]; Reduced spg4 function caused dramatic defects in motor axon outgrowth without affecting the events driving the initial specification of motor neurones., [RefSeq, PubMed]; Simultaneous knockdown of spastin and katanin caused a more severe phenotype than did individual knockdown of either gene, suggesting that they have different but related functions in supporting axon outgrowth., [RefSeq, PubMed]; The data suggest that defective BMP and neuropilin 1 signalling may contribute to the motor phenotype in a vertebrate model of spastin depletion. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that the spinal cord motor neuron axon outgrowth of zebrafish is regulated by the interaction between spastin and protrudin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6JUU0", "ec_number_list": "5.6.1.1", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0007409 axonogenesis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6NW58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NWF1-1", "uniprot_id": "GTR12_DANRE", "mass": 65778.0, "length": 610, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 12", "gene_name": "slc2a12", "organism": "Zebrafish", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 12", "refseq_ac": "NP_956832", "gene_names_uniprotkb": "slc2a12; glut12; zgc:66027; zgc:85776", "gene_names_refseq": "slc2a12; zgc:66027; zgc:85776", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 12; GLUT-12; Glucose transporter type 12", "protein_names_refseq": "GLUT-12; glucose transporter type 12; solute carrier family 2 (facilitated glucose transporter), member 12; solute carrier family 2, facilitated glucose transporter member 12; zglut12", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-189200)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25326603", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056306.1, BC067616.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056306.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Insulin-regulated facilitative glucose transporter., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHV4", "ec_number_list": "", "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0007507 heart development;GO:0060047 heart contraction;GO:0044381 glucose import in response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NWF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NWH2-1", "uniprot_id": "MRPB_DANRE", "mass": 20979.0, "length": 207, "protein_name": "MARCKS-related protein 1-B", "gene_name": "marcksl1b", "organism": "Zebrafish", "refseq_name": "MARCKS-related protein 1-B", "refseq_ac": "NP_998388", "gene_names_uniprotkb": "marcksl1b; marcksl1a; marcksl2; zgc:85717", "gene_names_refseq": "Marcksl2; marcks2; marcksl1a; marcksl1b; wu:fa11h06; zgc:85717", "protein_names_uniprotkb": "MARCKS-related protein 1-B; MARCKS-like protein 1-A; MARCKS-like protein 1-B", "protein_names_refseq": "MARCKS-like protein 1-A; MARCKS-like protein 1-B; MARCKS-related protein 1-B; myristoylated alanine-rich C kinase substrate 2", "tax_id": 7955, "disease": "", "pathway": " (dre:406504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;27554589;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC067590.1, BC154302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC067590.1., [RefSeq]; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0072554 blood vessel lumenization;GO:0003407 neural retina development;GO:0007015 actin filament organization;GO:0007417 central nervous system development;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NWH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYH1-1", "uniprot_id": "IF122_DANRE", "mass": 135765.0, "length": 1187, "protein_name": "Intraflagellar transport protein 122 homolog", "gene_name": "ift122", "organism": "Zebrafish", "refseq_name": "intraflagellar transport protein 122 homolog isoform 1", "refseq_ac": "NP_998055", "gene_names_uniprotkb": "ift122; zgc:77217", "gene_names_refseq": "ift122; zgc:77217", "protein_names_uniprotkb": "Intraflagellar transport protein 122 homolog", "protein_names_refseq": "intraflagellar transport protein 122 homolog isoform 1; intraflagellar transport protein 122 homolog", "tax_id": 7955, "disease": "cranioectodermal dysplasia 1 (Disease Ontology:DOID:0080803); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "20493458;27681595;29125377", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.1622316.1, SRR26395015.323172.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Jul 16, 2025 this sequence version replaced XP_073765368.1, NP_998055.1., [RefSeq]; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking., [UniProtKB, PubMed]; Collagen activation of wild-type thrombocytes led to a concentration of IFT122 both within and at the base of filopodia. Taken together these results, suggest that IFT proteins are involved in both the extension of filopodia and secretion of ATP, which are critical in thrombocyte function., [RefSeq, PubMed]; These results show that IFT-A is essential for the efficient transport of outer segment proteins, including opsin, and for the survival of retinal photoreceptor cells, rendering the ift122 mutant a unique model for human retinal degenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097730 non-motile cilium;GO:0036064 ciliary basal body;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0007507 heart development;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway;GO:0048593 camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NYH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYL3-1", "uniprot_id": "ECHP_DANRE", "mass": 78508.0, "length": 718, "protein_name": "Peroxisomal bifunctional enzyme", "gene_name": "ehhadh", "organism": "Zebrafish", "refseq_name": "peroxisomal bifunctional enzyme", "refseq_ac": "NP_996951", "gene_names_uniprotkb": "ehhadh; echd; si:dkeyp-30d5.2; zgc:77526", "gene_names_refseq": "MFE1; ehhadh; zgc:77526", "protein_names_uniprotkb": "Peroxisomal bifunctional enzyme; MFE1; Multifunctional enzyme 1; PBE; PBFE", "protein_names_refseq": "DKEYP-30D5.2; PBE; PBFE; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; l-pbe; multifunctional enzyme 1; peroxisomal bifunctional enzyme", "tax_id": 7955, "disease": "Fanconi renotubular syndrome 3 (Disease Ontology:DOID:0080759)", "pathway": " (dre:100000859); (R-DRE-390247)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066545.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066545.1. On Aug 30, 2007 this sequence version replaced XP_001336247.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long straight chain fatty acids peroxisomal beta-oxidation pathway (By similarity). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.3.8;1.1.1.35;4.2.1.17", "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0070403 NAD+ binding;GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NYL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYV5-1", "uniprot_id": "SP30L_DANRE", "mass": 20589.0, "length": 178, "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "sap30l", "organism": "Zebrafish", "refseq_name": "histone deacetylase complex subunit SAP30L", "refseq_ac": "NP_999868", "gene_names_uniprotkb": "sap30l", "gene_names_refseq": "sap30l; wu:fa26a11; wu:fc10g12; wu:fe36f07; zgc:77367", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP30L; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like", "protein_names_refseq": "Sin3A associated protein p30-like; histone deacetylase complex subunit SAP30L; sin3 corepressor complex subunit SAP30L; sin3-associated protein p30-like; sin3A-associated protein p30-like protein", "tax_id": 7955, "disease": "", "pathway": " (dre:327079); (R-DRE-3214815)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22821512", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066447.1, CA476915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066447.1., [RefSeq]; Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:22821512). Required for normal expression of numerous target genes (PubMed:22821512). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (By similarity)., [UniProtKB, UniProtKB, PubMed]; SAP30L regulates several transcriptional pathways in zebrafish embryos and is involved in the development of cardiac and hematopoietic systems., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NYV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYV8-1", "uniprot_id": "LCLT1_DANRE", "mass": 44745.0, "length": 388, "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "lclat1", "organism": "Zebrafish", "refseq_name": "lysocardiolipin acyltransferase 1", "refseq_ac": "NP_998435", "gene_names_uniprotkb": "lclat1; agpat8; lycat; zgc:77380", "gene_names_refseq": "1-AGPAT 8; lclat1; lycat1; lycat; wu:fj17g04; zgc:77380", "protein_names_uniprotkb": "Lysocardiolipin acyltransferase 1; 1-AGP acyltransferase 8; 1-AGPAT 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; 2.3.1.-; 2.3.1.51; Acyl-CoA:lysocardiolipin acyltransferase 1", "protein_names_refseq": "1-AGP acyltransferase 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; acyl-CoA:lysocardiolipin acyltransferase 1; lysocardiolipin acyltransferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:406554); (R-DRE-1482798); (R-DRE-1483166)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18388326", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.669066.1, SRR26395017.474746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Feb 18, 2016 this sequence version replaced XP_009305898.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:18388326)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0060217 hemangioblast cell differentiation;GO:0001885 endothelial cell development;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NYV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NYV9-1", "uniprot_id": "LEO1_DANRE", "mass": 76442.0, "length": 696, "protein_name": "RNA polymerase-associated protein LEO1", "gene_name": "leo1", "organism": "Zebrafish", "refseq_name": "RNA polymerase-associated protein LEO1", "refseq_ac": "NP_996950", "gene_names_uniprotkb": "leo1; zgc:77374", "gene_names_refseq": "leo1; zgc:77374", "protein_names_uniprotkb": "RNA polymerase-associated protein LEO1", "protein_names_refseq": "Leo1, Paf1/RNA polymerase II complex component, homolog; RNA polymerase-associated protein LEO1", "tax_id": 7955, "disease": "", "pathway": " (dre:404599); (R-DRE-201722); (R-DRE-674695); (R-DRE-75955); (R-DRE-9943411)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "20178782;21338598;22699901;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066443.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066443.1., [RefSeq]; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development., [UniProtKB, PubMed]; Results indicate that antagonistic regulation of gene expression by PAF1Cand p-TEFb plays a crucial role in oligodendrocyte development in the CNS., [RefSeq, PubMed]; These results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0021782 glial cell development;GO:0007507 heart development;GO:0014032 neural crest cell development;GO:0048701 embryonic cranial skeleton morphogenesis;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NYV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZ04-1", "uniprot_id": "SIX1B_DANRE", "mass": 31975.0, "length": 284, "protein_name": "Homeobox protein six1b", "gene_name": "six1b", "organism": "Zebrafish", "refseq_name": "homeobox protein six1b", "refseq_ac": "NP_996978", "gene_names_uniprotkb": "six1b; six1a; six1", "gene_names_refseq": "six1b; six1; zgc:77345", "protein_names_uniprotkb": "Homeobox protein six1b; Homeobox protein six1a; Sine oculis homeobox homolog 1a; Sine oculis homeobox homolog 1b", "protein_names_refseq": "homeobox protein six1a; homeobox protein six1b; homeodomain transcription factor six1; sine oculis homeobox homolog 1a; sine oculis homeobox homolog 1b; sine oculis homeobox homolog 1; six1a", "tax_id": 7955, "disease": "branchiootic syndrome 3 (Disease Ontology:DOID:0061210); autosomal dominant nonsyndromic deafness 23 (Disease Ontology:DOID:0110553); branchiootorenal syndrome (Disease Ontology:DOID:14702); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); neurilemmoma (Disease Ontology:DOID:3192); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:404627)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15254912;17035528;18789916;19409884;21745464;23444384;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066396.1, AY254196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC066396.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Six1 promotes inner hair cell fate and inhibits neuronal fate during development., [RefSeq, PubMed]; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as a transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. Required for normal expression of myod1 and myog during myogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05FF5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NZ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0E1-1", "uniprot_id": "SOX2_DANRE", "mass": 34698.0, "length": 315, "protein_name": "Transcription factor Sox-2", "gene_name": "sox2", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-2", "refseq_ac": "NP_998283", "gene_names_uniprotkb": "sox2; zgc:65860; zgc:77389", "gene_names_refseq": "cb236; sox2; soxp; wu:fb83g04; wu:fc14d07; zgc:65860; zgc:77389", "protein_names_uniprotkb": "Transcription factor Sox-2", "protein_names_refseq": "SRY (sex determining region Y)-box 2; SRY-box containing gene 2; transcription factor SOX2; transcription factor Sox-2", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); traumatic brain injury (Disease Ontology:DOID:0081292); syndromic microphthalmia 3 (Disease Ontology:DOID:0111801); nasal cavity cancer (Disease Ontology:DOID:10811); lesion of sciatic nerve (Disease Ontology:DOID:12528); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); cholangiocarcinoma (Disease Ontology:DOID:4947); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (dre:378723); (R-DRE-3769402)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16324829;16408288;16543359", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065656.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065656.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0031099 regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P0E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0E5-1", "uniprot_id": "DDRGK_DANRE", "mass": 34431.0, "length": 300, "protein_name": "DDRGK domain-containing protein 1", "gene_name": "ddrgk1", "organism": "Zebrafish", "refseq_name": "DDRGK domain-containing protein 1", "refseq_ac": "NP_956587", "gene_names_uniprotkb": "ddrgk1; zgc:56488", "gene_names_refseq": "ddrgk1; zgc:56488; zgc:77356", "protein_names_uniprotkb": "DDRGK domain-containing protein 1", "protein_names_refseq": "DDRGK domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:393263); (R-DRE-8980692)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28263186", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065652.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065652.1. On Jul 12, 2004 this sequence version replaced NP_956587.1., [RefSeq]; Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins (By similarity). The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane (By similarity). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Plays a role in cartilage development through sox9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). Required for stabilization and ufmylation of ATG9A (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0141185 UFM1-modified protein reader activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0031647 regulation of protein stability;GO:0070972 protein localization to endoplasmic reticulum;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P0E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P0F9-1", "uniprot_id": "INS1A_DANRE", "mass": 42875.0, "length": 383, "protein_name": "Insulinoma-associated protein 1a", "gene_name": "insm1a", "organism": "Zebrafish", "refseq_name": "insulinoma-associated protein 1a", "refseq_ac": "NP_991207", "gene_names_uniprotkb": "insm1a", "gene_names_refseq": "insm1a; zgc:77257", "protein_names_uniprotkb": "Insulinoma-associated protein 1a; Insulinoma-associated 1-like protein a; Zinc finger protein IA-1a", "protein_names_refseq": "insulinoma-associated 1-like protein a; insulinoma-associated protein 1a; zinc finger protein IA-1a", "tax_id": 7955, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (dre:402941)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16487754;23000964;23594743;23747542", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065636.1, DQ164184.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065636.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analaysis of the data identified Insm1a as a key regulator of retina regeneration and provide a mechanistic understanding of how Insm1a contributes to multiple phases of this process., [RefSeq, PubMed]; Characterization of two zebrafish Insm1-like genes, insm1a and insm1b, and analysis of their expression patterns during embryonic development, [RefSeq, PubMed]; Insm1a-deficient embryos were microphthalmic and displayed defects in rod and cone photoreceptor differentiation, [RefSeq, PubMed]; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3S5C8", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P0F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P2A1-1", "uniprot_id": "PRDM9_DANRE", "mass": 97136.0, "length": 853, "protein_name": "Histone-lysine N-methyltransferase PRDM9", "gene_name": "prdm9", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase PRDM9", "refseq_ac": "NP_957196", "gene_names_uniprotkb": "prdm9; zgc:63970", "gene_names_refseq": "prdm9; zgc:63970", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM9; 2.1.1.-; 2.1.1.354; 2.1.1.355; 2.1.1.359; 2.1.1.361; 2.1.1.362; PR domain zinc finger protein 9; PR domain-containing protein 9; Protein-lysine N-methyltransferase PRDM9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9", "protein_names_refseq": "PR domain zinc finger protein 9; PR domain-containing protein 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; histone-lysine N-methyltransferase PRDM9; protein-lysine N-methyltransferase PRDM9", "tax_id": 7955, "disease": "", "pathway": " (dre:393876)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18231586", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC064665.1, CN507369.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064665.1., [RefSeq]; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Can also methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate. During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity. Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression. During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8. In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation. Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation. In addition performs automethylation. Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5XCD9", "ec_number_list": "2.1.1.361;2.1.1.362;2.1.1.354;2.1.1.-;2.1.1.359;2.1.1.372;2.1.1.364;2.1.1.355", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0010844 recombination hotspot binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0010468 regulation of gene expression;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P2A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3K7-1", "uniprot_id": "KC1DB_DANRE", "mass": 46831.0, "length": 409, "protein_name": "Casein kinase I isoform delta-B", "gene_name": "csnk1db", "organism": "Zebrafish", "refseq_name": "casein kinase I isoform delta-B", "refseq_ac": "NP_998415", "gene_names_uniprotkb": "csnk1db", "gene_names_refseq": "csnk1db; csnk1d; wu:fb69b03; wu:fj97a05; zgc:77627", "protein_names_uniprotkb": "Casein kinase I isoform delta-B; 2.7.11.1; CKI-delta-B; CKId-B", "protein_names_refseq": "CKI-delta-B; CKId-B; casein kinase I isoform delta-B", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); colon cancer (Disease Ontology:DOID:219)", "pathway": " (dre:406533); (R-DRE-380320); (R-DRE-6791226)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18064361;20041275", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC063953.1, EU127825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063953.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity)., [UniProtKB]; The phosphorylation of p53 by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop. Erratum:[Cell Mol Life Sci. 2011 Mar;68(5):919], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V962", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;3.1.3.16;2.7.11.31;3.1.26.5", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005876 spindle microtubule", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0042752 regulation of circadian rhythm;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P3K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P7E4-1", "uniprot_id": "PDLI7_DANRE", "mass": 45592.0, "length": 419, "protein_name": "PDZ and LIM domain protein 7", "gene_name": "pdlim7", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pdlim7; zgc:65907; zgc:85607", "gene_names_refseq": "", "protein_names_uniprotkb": "PDZ and LIM domain protein 7", "protein_names_refseq": "", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); myopathy (Disease Ontology:DOID:423)", "pathway": " (dre:393813); (R-DRE-8853659)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15732137;17937393;19895804;20950450;22580902;27189481;29942316;32081808;40044042", "class_list": "", "function": "May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0048471 perinuclear region of cytoplasm;GO:0001725 stress fiber", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0001756 somitogenesis;GO:0003143 embryonic heart tube morphogenesis;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P7E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBT8-1", "uniprot_id": "FGF1_DANRE", "mass": 16638.0, "length": 147, "protein_name": "Putative fibroblast growth factor 1", "gene_name": "fgf1", "organism": "Zebrafish", "refseq_name": "putative fibroblast growth factor 1", "refseq_ac": "NP_957054", "gene_names_uniprotkb": "fgf1; fgf-1; zgc:73249", "gene_names_refseq": "HBGF-1; aFGF; fgf1a; fgf1; zgc:73249", "protein_names_uniprotkb": "Putative fibroblast growth factor 1; Acidic fibroblast growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; aFGF", "protein_names_refseq": "FGF-1; acidic fibroblast growth factor; fibroblast growth factor 1; heparin-binding growth factor 1; putative fibroblast growth factor 1; putative heparin-binding growth factor 1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); endometrial cancer (Disease Ontology:DOID:1380); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dre:393733); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190322); (R-DRE-190370); (R-DRE-190371); (R-DRE-190372); (R-DRE-190373); (R-DRE-190375); (R-DRE-190377); (R-DRE-5654219); (R-DRE-5654221); (R-DRE-5654227); (R-DRE-5654228); (R-DRE-5654687); (R-DRE-5654688); (R-DRE-5654689); (R-DRE-5654693); (R-DRE-5654695); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654710); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654726); (R-DRE-5654727); (R-DRE-5654732); (R-DRE-5654733); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 33, "publication_count": 3, "publication_id_list": "17219402;19503807;20616095", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH440935.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505389 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059588.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fgf and Sdf-1 pathways interact during zebrafish fin regeneration Publication Status: Online-Only, [RefSeq, PubMed]; Fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis., [RefSeq, PubMed]; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling., [UniProtKB, UniProtKB]; Ship2a attenuates the FGF signaling pathway in vivo and functions in the establishment of normal tissue patterning in the early embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5TLE3", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PBT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PBW5-1", "uniprot_id": "RP65A_DANRE", "mass": 60789.0, "length": 531, "protein_name": "Retinoid isomerohydrolase", "gene_name": "rpe65a", "organism": "Zebrafish", "refseq_name": "retinoid isomerohydrolase", "refseq_ac": "NP_957045", "gene_names_uniprotkb": "rpe65a; rpepa", "gene_names_refseq": "RPE56a; rpe65a; rpepa; zgc:73213", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinylester 11-cis isomerohydrolase A; Lutein isomerase; Meso-zeaxanthin isomerase; RPE56a; Retinal pigment epithelium-specific 65 kDa protein homolog A", "protein_names_refseq": "all-trans-retinylester 11-cis isomerohydrolase A; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65a; retinal pigment epithelium-specific 65 kDa protein homolog A; retinal pigment epithelium-specific protein 65a; retinal pigment epithelium-specific protein a; retinoid isomerohydrolase", "tax_id": 7955, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (dre:393724); (R-DRE-2453902)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17868371;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY646886.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059559.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.64;5.3.3.22;3.1.1.90", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0052884 all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity;GO:0052885 all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity;GO:0050251 retinol isomerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0007601 visual perception;GO:0042574 retinal metabolic process;GO:1901827 zeaxanthin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PBW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC64-1", "uniprot_id": "ELOV6_DANRE", "mass": 31279.0, "length": 266, "protein_name": "Very long chain fatty acid elongase 6", "gene_name": "elovl6", "organism": "Zebrafish", "refseq_name": "very long chain fatty acid elongase 6", "refseq_ac": "NP_955826", "gene_names_uniprotkb": "elovl6", "gene_names_refseq": "cb618; elovl6; lce; zgc:73089", "protein_names_uniprotkb": "Very long chain fatty acid elongase 6; 2.3.1.199; 3-keto acyl-CoA synthase elovl6; ELOVL FA elongase 6; ELOVL fatty acid elongase 6; Elongation of very long chain fatty acids protein 6; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6", "protein_names_refseq": "3-keto acyl-CoA synthase elovl6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 6; fatty acid elongase 6; long-chain fatty-acyl elongase; very long chain 3-ketoacyl-CoA synthase 6; very long chain 3-oxoacyl-CoA synthase 6; very long chain fatty acid elongase 6", "tax_id": 7955, "disease": "", "pathway": " (dre:317738); (R-DRE-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CK870700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059459.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0030497 fatty acid elongation;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PC64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PC72-1", "uniprot_id": "CIB2_DANRE", "mass": 21759.0, "length": 187, "protein_name": "Calcium and integrin-binding family member 2", "gene_name": "cib2", "organism": "Zebrafish", "refseq_name": "calcium and integrin-binding family member 2", "refseq_ac": "NP_957000", "gene_names_uniprotkb": "cib2; zgc:73079", "gene_names_refseq": "cib2; zgc:73079", "protein_names_uniprotkb": "Calcium and integrin-binding family member 2", "protein_names_refseq": "calcium and integrin-binding family member 2", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 48 (Disease Ontology:DOID:0110505)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23023331;23594743;38035267", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CO920792.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059451.1. On Jul 6, 2005 this sequence version replaced XP_702331.1., [RefSeq]; Calcium- and integrin-binding protein (By similarity). Plays a role in intracellular calcium homeostasis (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Essential for development, maintenance and function of mechanosensory hair cells (PubMed:23023331)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells Erratum:[Nat Genet. 2025 Sep;57(9):2340-2342. doi: 10.1038/s41588-025-02332-w. PMID: 40858907], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PEW7", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0071944 cell periphery;GO:0042383 sarcolemma;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0055074 calcium ion homeostasis;GO:0043010 camera-type eye development;GO:0048884 neuromast development;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PC72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD99-1", "uniprot_id": "MRPA_DANRE", "mass": 22094.0, "length": 213, "protein_name": "MARCKS-related protein 1-A", "gene_name": "marcksl1a", "organism": "Zebrafish", "refseq_name": "MARCKS-related protein 1-A", "refseq_ac": "NP_998298", "gene_names_uniprotkb": "marcksl1a; marcksl1b; marcksl1", "gene_names_refseq": "MLP; cb575; marcks1; marcksl1a; marcksl1b; marcksl1; sb:cb575; wu:fa66h03; wu:fj18a04; zgc:65840", "protein_names_uniprotkb": "MARCKS-related protein 1-A; MARCKS-like protein 1-A; MARCKS-like protein 1-B", "protein_names_refseq": "MARCKS-like 1; MARCKS-like protein 1-A; MARCKS-like protein 1-B; MARCKS-related protein 1-A", "tax_id": 7955, "disease": "", "pathway": " (dre:406407)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;27554589;33127887;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058848.1, EH451787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058848.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation., [UniProtKB, UniProtKB]; Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0072554 blood vessel lumenization;GO:0003407 neural retina development;GO:0007015 actin filament organization;GO:0007417 central nervous system development;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6PD99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE18-1", "uniprot_id": "P4K2A_DANRE", "mass": 51443.0, "length": 447, "protein_name": "Phosphatidylinositol 4-kinase type 2-alpha", "gene_name": "pi4k2a", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 4-kinase type 2-alpha", "refseq_ac": "NP_998523", "gene_names_uniprotkb": "pi4k2a; pi4kii; si:ch211-197k17.1", "gene_names_refseq": "pi4k2a; pi4kII alpha; pi4kii; wu:fc84f05; zgc:63646", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-alpha; 2.7.1.67; Phosphatidylinositol 4-kinase type II-alpha", "protein_names_refseq": "PI4KII-alpha; phosphatidylinositol 4-kinase II alpha; phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II-alpha", "tax_id": 7955, "disease": "", "pathway": " (dre:406667); (R-DRE-1660499); (R-DRE-1660514); (R-DRE-1660516)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01030313.1, SRR26395028.938336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Apr 18, 2008 this sequence version replaced NP_001094097.1., [RefSeq]; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PF25;Q52PF3", "ec_number_list": "2.7.1.67", "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0035838 growing cell tip;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0006661 phosphatidylinositol biosynthetic process;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PE18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFM0-1", "uniprot_id": "JMJD6_DANRE", "mass": 46687.0, "length": 403, "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "gene_name": "jmjd6", "organism": "Zebrafish", "refseq_name": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "refseq_ac": "NP_739567", "gene_names_uniprotkb": "jmjd6; psr; ptdsr; zgc:66264", "gene_names_refseq": "jmjd6a; jmjd6; psr; ptdsr; zfpsr; zgc:66264", "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; zfpsr", "protein_names_refseq": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain-containing protein 6; lysyl-hydroxylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor", "tax_id": 7955, "disease": "", "pathway": " (dre:266962); (R-DRE-3214842); (R-DRE-9629569)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15469976;26924789", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.422144.1, SRR32588723.454744.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On or before Feb 26, 2016 this sequence version replaced XP_005168542.1, NP_739567.2. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite, [RefSeq, PubMed]; Results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JI07;Q8JI08", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PFM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGY3-1", "uniprot_id": "TXTPA_DANRE", "mass": 39412.0, "length": 359, "protein_name": "Tricarboxylate transport protein A, mitochondrial", "gene_name": "slc25a1a", "organism": "Zebrafish", "refseq_name": "tricarboxylate transport protein A, mitochondrial", "refseq_ac": "NP_956901", "gene_names_uniprotkb": "slc25a1a; zgc:63578", "gene_names_refseq": "slc25a1a; slc25a1; zgc:63578", "protein_names_uniprotkb": "Tricarboxylate transport protein A, mitochondrial; Citrate transport protein A; Solute carrier family 25 member 1a", "protein_names_refseq": "cic; citrate transport protein A; citrate transporter), member 1a; citrate transporter), member 1; solute carrier family 25 (mitochondrial carrier; solute carrier family 25, member 1; tricarboxylate transport protein A, mitochondrial", "tax_id": 7955, "disease": "2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050573); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); combined D-2- and L-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0111619); DiGeorge syndrome (Disease Ontology:DOID:11198); congenital myasthenic syndrome (Disease Ontology:DOID:3635); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dre:393579)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;26870663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056787.1, CV489993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056787.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (PubMed:26870663)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015142 tricarboxylic acid transmembrane transporter activity;GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0010821 regulation of mitochondrion organization;GO:0006843 mitochondrial citrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PGY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGY6-1", "uniprot_id": "UFL1_DANRE", "mass": 88679.0, "length": 793, "protein_name": "E3 UFM1-protein ligase 1", "gene_name": "ufl1", "organism": "Zebrafish", "refseq_name": "E3 UFM1-protein ligase 1", "refseq_ac": "NP_956900", "gene_names_uniprotkb": "ufl1; zgc:63562", "gene_names_refseq": "ufl1; zgc:63562", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1; 2.3.2.-; E3 UFM1-protein transferase 1", "protein_names_refseq": "E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:393578); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056784.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056784.1. On Jul 6, 2005 this sequence version replaced XP_690867.1., [RefSeq]; E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome. Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane. Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum. Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061666 UFM1 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0060218 hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PGY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHH3-1", "uniprot_id": "PD10A_DANRE", "mass": 24380.0, "length": 210, "protein_name": "Programmed cell death protein 10-A", "gene_name": "pdcd10a", "organism": "Zebrafish", "refseq_name": "programmed cell death protein 10-A", "refseq_ac": "NP_956849", "gene_names_uniprotkb": "pdcd10a; ccm3a; pdcd10; si:ch211-167c22.5; zgc:65826", "gene_names_refseq": "ccm3a; pdcd10a; pdcd10; zgc:65826", "protein_names_uniprotkb": "Programmed cell death protein 10-A", "protein_names_refseq": "programmed cell death 10; programmed cell death protein 10-A", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 3 (Disease Ontology:DOID:0060671); varicocele (Disease Ontology:DOID:12337); hepatitis (Disease Ontology:DOID:2237); endometrial adenocarcinoma (Disease Ontology:DOID:2870); liver cirrhosis (Disease Ontology:DOID:5082); liver carcinoma (Disease Ontology:DOID:686)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "19370760;21561863;22182521;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH548629.1, BC056552.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH548629.1 and JBMGRA010000018.1. On Sep 30, 2011 this sequence version replaced NP_956849.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; CCM3 plays a role distinct from CCM1/2 in Cerebral cavernous malformations pathogenesis, and acts via GCKIII activity to regulate cranial vasculature integrity and development., [RefSeq, PubMed]; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (PubMed:19370760). Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Sequence conservation and binding studies suggest that CCM3 may preferentially heterodimerize with GCKIII proteins through a manner structurally analogous to that employed for CCM3 homodimerization., [RefSeq, PubMed]; The newly mapped STK25 and MST4 interaction domain within the CCM3 protein plays a crucial role for vascular development in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DZ91", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0006915 apoptotic process;GO:0048514 blood vessel morphogenesis;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PHH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PI20-1", "uniprot_id": "H33_DANRE", "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "h3-5; h3f3a; h3f3b.1; h3f3d", "organism": "Zebrafish", "refseq_name": "histone H3.3", "refseq_ac": "NP_001017599", "gene_names_uniprotkb": "h3-5; h3f3a; h3f3b.1; h3f3d; fb58e10; h3f3a; h3f3c; si:ch1073-429i10.3; wu:fb58e10; zgc:110292; zgc:56193; zgc:56418; zgc:64222; zgc:86731", "gene_names_refseq": "h3-5; h3f3a; h3f3b.1; h3f3c; h3f3d; wu:fa25h06; wu:fa96g06; wu:fb07a08; wu:fb36f01; zgc:110292; zgc:174300", "protein_names_uniprotkb": "Histone H3.3", "protein_names_refseq": "histone H3.3", "tax_id": 7955, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome 1 (Disease Ontology:DOID:0051011); Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012); diffuse midline glioma, H3 K27-altered (Disease Ontology:DOID:0080684)", "pathway": " (dre:100331798); (dre:336231); (dre:394076); (dre:550262)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092854.1, DV597018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PL96;Q7ZV67", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PI20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QA32-1", "uniprot_id": "DHB3_DANRE", "mass": 34018.0, "length": 307, "protein_name": "17-beta-hydroxysteroid dehydrogenase type 3", "gene_name": "hsd17b3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hsd17b3; zgc:64019", "gene_names_refseq": "", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 3; 1.1.1.64; 17-beta-HSD 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3", "protein_names_refseq": "", "tax_id": 7955, "disease": "17-beta hydroxysteroid dehydrogenase 3 deficiency (Disease Ontology:DOID:0112248); Alzheimer's disease (Disease Ontology:DOID:10652); disorder of sexual development (Disease Ontology:DOID:1923); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393335); (R-DRE-193048); (R-DRE-75876)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16216911;23594743;27927697", "class_list": "", "function": "Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids in the presence of NADPH (PubMed:16216911, PubMed:27927697). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697). Testosterone is the key androgen driving male development and function (By similarity). Among further tested androgens epiandrosterone and dehydroepiandrosterone are accepted as substrates and reduced at C-17 (PubMed:16216911). Can also reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697). Cannot use androsterone and androstanedione as substrates (PubMed:16216911)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.330;1.1.1.62;1.1.1.64", "go_molecular_function": "GO:0047045 testosterone dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006702 androgen biosynthetic process;GO:0061370 testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6QA32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QU75-1", "uniprot_id": "PITX3_DANRE", "mass": 32438.0, "length": 293, "protein_name": "Pituitary homeobox 3", "gene_name": "pitx3", "organism": "Zebrafish", "refseq_name": "pituitary homeobox 3", "refseq_ac": "NP_991238", "gene_names_uniprotkb": "pitx3; si:dkey-196H17.1; zgc:109716", "gene_names_refseq": "pitx3; zgc:109716", "protein_names_uniprotkb": "Pituitary homeobox 3; Bicoid-like homeodomain transcription factor Pitx3; Homeobox protein PITX3; Paired-like homeodomain transcription factor 3", "protein_names_refseq": "bicoid-like homeodomain transcription factor 3; homeobox protein PITX3; pituitary homeobox 3", "tax_id": 7955, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 1 (Disease Ontology:DOID:0080606); cataract 11 multiple types (Disease Ontology:DOID:0110249); cataract 9 multiple types (Disease Ontology:DOID:0110266); Parkinson's disease (Disease Ontology:DOID:14330); cataract (Disease Ontology:DOID:83)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "15645439;15728669;15804565;18053265;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY525643.1, BC094961.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505386, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY525643.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Expressing cells constitute an equivalence domain of cells that can form either pituitary or lens, [RefSeq, PubMed]; Pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog and nodal proteins' signaling., [RefSeq, PubMed]; Results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish, [RefSeq, PubMed]; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DUF5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0035270 endocrine system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6QU75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R005-1", "uniprot_id": "DLG4_DANRE", "mass": 89140.0, "length": 801, "protein_name": "Disks large homolog 4", "gene_name": "dlg4", "organism": "Zebrafish", "refseq_name": "disks large homolog 4", "refseq_ac": "NP_999893", "gene_names_uniprotkb": "dlg4", "gene_names_refseq": "dlg4b; dlg4", "protein_names_uniprotkb": "Disks large homolog 4; PSD-95; Postsynaptic density protein 95", "protein_names_refseq": "PSD-95; PSD95/SAP90; discs, large homolog 4; disks large homolog 4; postsynaptic density protein 95", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); autosomal dominant intellectual developmental disorder 62 (Disease Ontology:DOID:0061035); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); Williams-Beuren syndrome (Disease Ontology:DOID:1928); carcinoma (Disease Ontology:DOID:305); temporal lobe epilepsy (Disease Ontology:DOID:3328); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:405796); (R-DRE-438066); (R-DRE-8849932)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14758365;15660367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.40186629.1, SRR26395028.351185.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043005 neuron projection;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0097113 AMPA glutamate receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6R005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R8J2-1", "uniprot_id": "HEG_DANRE", "mass": 105529.0, "length": 977, "protein_name": "Protein HEG", "gene_name": "heg1; heg", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "heg1; heg; heg", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein HEG; Heart of glass", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "14680629;19151727", "class_list": "", "function": "Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6R8J3;Q6R8J4", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007507 heart development;GO:0007043 cell-cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6R8J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEL0-1", "uniprot_id": "MTMR8_DANRE", "mass": 72503.0, "length": 632, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8", "gene_name": "mtmr8", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8", "refseq_ac": "NP_956688", "gene_names_uniprotkb": "mtmr8; mtmr6; si:dkey-286f3.1; zgc:56405", "gene_names_refseq": "mtmr8; si:dkey-286f3.1; zgc:56405", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8; 3.1.3.95; Myotubularin-related protein 6; Myotubularin-related protein 8; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "myotubularin-related protein 6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 7955, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (dre:393365); (R-DRE-1660499)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15520368;19325702;20815916;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053411.1, AY423041.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053411.1., [RefSeq]; A conserved functional cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development, [RefSeq, PubMed]; Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate., [UniProtKB, UniProtKB]; These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SZD1", "ec_number_list": "3.1.3.95;3.1.3.64", "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0004708 MAP kinase kinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0001568 blood vessel development;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046856 phosphatidylinositol dephosphorylation;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TEL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEM9-1", "uniprot_id": "MYLIA_DANRE", "mass": 53434.0, "length": 472, "protein_name": "E3 ubiquitin-protein ligase MYLIP-A", "gene_name": "mylipa", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase MYLIP-A", "refseq_ac": "NP_956277", "gene_names_uniprotkb": "mylipa; mir; mylip; si:ch211-266j17.1", "gene_names_refseq": "Mir; mylipa; mylip; wu:fj36b03; zgc:55987", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MYLIP-A; 2.3.2.27; MIR-A; Myosin regulatory light chain-interacting protein A; RING-type E3 ubiquitin transferase MYLIP-A", "protein_names_refseq": "E3 ubiquitin-protein ligase MYLIP-A; MIR-A; RING-type E3 ubiquitin transferase MYLIP-A; myosin regulatory light chain-interacting protein A", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:335888); (R-DRE-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14651927;15520368;18248225;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045844.1, AY423020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Aug 8, 2023 this sequence version replaced NP_956277.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway., [UniProtKB, PubMed, PubMed]; Essential for embryonic development, with a role in the extensive cell movements associated with gastrulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LUH7;Q6P0B8;Q6T628;Q7ZVI9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030178 negative regulation of Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0007369 gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TEM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TEN1-1", "uniprot_id": "RAP1B_DANRE", "mass": 20828.0, "length": 184, "protein_name": "Ras-related protein Rap-1b", "gene_name": "rap1b", "organism": "Zebrafish", "refseq_name": "ras-related protein Rap-1b", "refseq_ac": "NP_955827", "gene_names_uniprotkb": "rap1b; si:dkey-31f5.4", "gene_names_refseq": "cb1026; cb119; rap1b; sb:cb119; wu:fb11c04; wu:fb74e09; wu:fk70e05", "protein_names_uniprotkb": "Ras-related protein Rap-1b; 3.6.5.2", "protein_names_refseq": "RAS related protein 1b; ras-related protein Rap-1b", "tax_id": 7955, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (dre:321107); (R-DRE-354192); (R-DRE-354194); (R-DRE-392517); (R-DRE-5674135); (R-DRE-6798695)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "15520368;21636859;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044548.1, AY423018.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044548.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity)., [UniProtKB]; Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b and VEGFR2 act additively to control angiogenesis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RGV9;Q803B8", "ec_number_list": "2.7.11.1;3.6.5.2;3.6.5.3;2.7.10.2;3.6.5.5;3.6.1.5;3.6.5.-;2.5.1.18;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.6.1.-;3.6.4.-;3.6.5.4;3.4.23.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0004708 MAP kinase kinase activity;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0032486 Rap protein signal transduction;GO:0007507 heart development;GO:0071320 cellular response to cAMP;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6TEN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VN46-1", "uniprot_id": "MYG_DANRE", "mass": 15583.0, "length": 147, "protein_name": "Myoglobin", "gene_name": "mb", "organism": "Zebrafish", "refseq_name": "myoglobin", "refseq_ac": "NP_956880", "gene_names_uniprotkb": "mb; zgc:65819; zgc:77764", "gene_names_refseq": "mb; zgc:65819; zgc:77764", "protein_names_uniprotkb": "Myoglobin; 1.11.1.-; 1.7.-.-; Nitrite reductase MB; Pseudoperoxidase MB", "protein_names_refseq": "myoglobin; nitrite reductase MB; pseudoperoxidase MB", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); iron deficiency anemia (Disease Ontology:DOID:11758); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); acute kidney failure (Disease Ontology:DOID:3021); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); hyperthyroidism (Disease Ontology:DOID:7998); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (dre:393558); (R-DRE-8981607)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15050521;16169945;16709914;16966387;17251491;29400650;31820205;34591853;36671767;37847464", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH454055.1, EH452679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Apr 13, 2018 this sequence version replaced XP_005160225.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Generation and validation of a myoglobin knockout zebrafish model., [RefSeq, PubMed]; Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P028", "ec_number_list": "1.11.1.-;1.15.1.1;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004601 peroxidase activity;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0016528 sarcoplasm", "go_biological_process": "GO:0001570 vasculogenesis;GO:0003009 skeletal muscle contraction;GO:0001666 response to hypoxia;GO:0014823 response to activity;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6VN46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YLH9-1", "uniprot_id": "Q6YLH9_DANRE", "mass": 20653.0, "length": 181, "protein_name": "Caveolin", "gene_name": "cav1", "organism": "Zebrafish", "refseq_name": "caveolin-1 isoform a", "refseq_ac": "NP_997816", "gene_names_uniprotkb": "cav1; wu:fc07c04", "gene_names_refseq": "cav1; wu:fc07c04", "protein_names_uniprotkb": "Caveolin", "protein_names_refseq": "caveolin-1 isoform a", "tax_id": 7955, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital generalized lipodystrophy type 3 (Disease Ontology:DOID:0111137); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); leiomyoma (Disease Ontology:DOID:127); primary pulmonary hypertension (Disease Ontology:DOID:14557); hypothyroidism (Disease Ontology:DOID:1459); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); psoriasis (Disease Ontology:DOID:8893); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-203641); (R-DRE-210991); (R-DRE-4641262); (R-DRE-8980692); (R-DRE-9009391); (R-DRE-9013026); (R-DRE-9013106); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013406); (R-DRE-9013407); (R-DRE-9013408); (R-DRE-9013423); (R-DRE-9035034); (R-DRE-9696264); (R-DRE-9696270); (R-DRE-9696273)", "pathway_count": 18, "publication_count": 11, "publication_id_list": "12917688;15888488;16109975;17148682;17550965;34557935;34633413;34943942;35312773;36835354;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY124572.1, GW713728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY124572.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., [UniProtKB, UniProtKB]; These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IX30;A0M8V7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005901 caveola", "go_biological_process": "GO:0061026 cardiac muscle tissue regeneration;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6YLH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q708S7-1", "uniprot_id": "ASI1A_DANRE", "mass": 57419.0, "length": 501, "protein_name": "Acid-sensing ion channel 1A", "gene_name": "asic1a", "organism": "Zebrafish", "refseq_name": "acid-sensing ion channel 1A", "refseq_ac": "NP_999955", "gene_names_uniprotkb": "asic1a; accn2b", "gene_names_refseq": "ASIC1-A; ASIC1; accn2b; asic1a; zASIC1.2", "protein_names_uniprotkb": "Acid-sensing ion channel 1A; ASIC1-A; Acid-sensing ion channel 1.2-A; Amiloride-sensitive cation channel 2-B, neuronal-A; ZASIC1.2", "protein_names_refseq": "acid-sensing ion channel 1.2-A; acid-sensing ion channel 1.2; acid-sensing ion channel 1A; acid-sensing ion channel 1; amiloride-sensitive cation channel 2 b; amiloride-sensitive cation channel 2-B, neuronal-A; amiloride-sensitive cation channel 2-B, neuronal", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); ischemia (Disease Ontology:DOID:326)", "pathway": " (dre:791696); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14970195;25446097", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA3505388 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162330.1. On Jun 7, 2009 this sequence version replaced XP_001331773.1., [RefSeq]; ASIC1 is expressed in the retina of zebrafish, [RefSeq, PubMed]; Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:14970195). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:14970195). Displays high selectivity for sodium ions but can also permit the permeation of other cations (By similarity)., [UniProtKB, PubMed, UniProtKB]; The 6 zasic genes studied are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. zASICs are activated by extracellular H(+), Na(+) selectivity and blocked by amiloride., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0005261 monoatomic cation channel activity;GO:0160128 pH-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0071467 cellular response to pH", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q708S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70X92-1", "uniprot_id": "ASB11_DANRE", "mass": 31531.0, "length": 293, "protein_name": "Ankyrin repeat and SOCS box protein 11", "gene_name": "asb11", "organism": "Zebrafish", "refseq_name": "ankyrin repeat and SOCS box protein 11", "refseq_ac": "NP_999957", "gene_names_uniprotkb": "asb11; zgc:136370; zgc:158532", "gene_names_refseq": "ASB-11; asb-a; asb11; zgc:136370; zgc:158532", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box protein 11; ASB-11; d-asb11", "protein_names_refseq": "ankyrin repeat and SOCS box containing protein a; ankyrin repeat and SOCS box protein 11; d-asb11", "tax_id": 7955, "disease": "", "pathway": " (dre:791758); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16893969;18776899;21124961;22512762;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ510191.1, GFIL01001646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Feb 13, 2010 this sequence version replaced NP_001038778.1., [RefSeq]; D-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism.[d-Asb11], [RefSeq, PubMed]; Data show that the d-Asb11 cullin box is required for both canonical Notch signaling and proper neurogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18776899). Acts as a regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state (PubMed:16893969). The ECS(ASB11) complex acts as a positive regulator of Notch signaling pathway by mediating ubiquitination and degradation of DeltaA (dla) (PubMed:18776899, PubMed:21124961). Also acts as a regulator of regenerative myogenesis (PubMed:22512762)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors., [RefSeq, PubMed]; Zebrafish homozygous for a hypomorphic Asb11 mutation are impaired in muscle progenitor expansion and myotome formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PR96", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0045665 negative regulation of neuron differentiation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045747 positive regulation of Notch signaling pathway;GO:0016567 protein ubiquitination;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q70X92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76LC6-1", "uniprot_id": "RBM24_DANRE", "mass": 24601.0, "length": 230, "protein_name": "RNA-binding protein 24", "gene_name": "rbm24a; rbm24", "organism": "Zebrafish", "refseq_name": "RNA-binding protein 24", "refseq_ac": "NP_998030", "gene_names_uniprotkb": "rbm24a; rbm24; rbm24; seb-4", "gene_names_refseq": "rbm24a; rbm24; seb-4", "protein_names_uniprotkb": "RNA-binding protein 24; RNA-binding motif protein 24; RNA-binding protein SEB-4", "protein_names_refseq": "RNA binding protein; RNA-binding motif protein 24; RNA-binding protein 24; RNA-binding protein SEB-4", "tax_id": 7955, "disease": "microphthalmia (Disease Ontology:DOID:10629); dilated cardiomyopathy (Disease Ontology:DOID:12930); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:405801)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22011202;22345307;25170925;36965272", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB080735.1, BC163027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB080735.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Both Rbm24a and Rbm24b are also required for normal somite and craniofacial development. Publication Status: Online-Only, [RefSeq, PubMed]; Cellular activity of autophagy and multivesicular bodies in lens fiber cells during early lens development in rbm24a mutant of zebrafish: Ultrastructure analysis., [RefSeq, PubMed]; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:22345307)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Rbm24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility., [RefSeq, PubMed]; Rbm24a is a key developmental cardiac genes with unequal roles in cardiovascular formation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:1990715 mRNA CDS binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0072359 circulatory system development;GO:0010830 regulation of myotube differentiation;GO:0006397 mRNA processing;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76LC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SX99-1", "uniprot_id": "FUMH_DANRE", "mass": 54861.0, "length": 509, "protein_name": "Fumarate hydratase, mitochondrial", "gene_name": "fh", "organism": "Zebrafish", "refseq_name": "fumarate hydratase, mitochondrial precursor", "refseq_ac": "NP_957257", "gene_names_uniprotkb": "fh; zgc:66253", "gene_names_refseq": "Fh1; fh; im:7152785; ns:zf-e152; zf-e152; zgc:66253; zgc:77498", "protein_names_uniprotkb": "Fumarate hydratase, mitochondrial; 4.2.1.2; Fumarase", "protein_names_refseq": "fumarase; fumarate hydratase, mitochondrial precursor; fumarate hydratase, mitochondrial", "tax_id": 7955, "disease": "fumarase deficiency (Disease Ontology:DOID:0111261); lung non-small cell carcinoma (Disease Ontology:DOID:3908); leiomyomatosis (Disease Ontology:DOID:5138)", "pathway": " (dre:393938); (R-DRE-71403); (R-DRE-9837999)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "32969324;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055566.1, BC066484.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055566.1. On Jul 6, 2005 this sequence version replaced XP_684984.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH., [UniProtKB, UniProtKB]; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)., [UniProtKB, UniProtKB]; Identification of zebrafish fumarate hydratase active site by molecular docking and simulation studies., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.2.3;3.4.21.53;1.2.4.1;1.2.4.2;2.7.11.-;3.6.4.10;1.3.8.1;1.3.8.5;2.3.1.9;4.2.1.2;2.3.3.1", "go_molecular_function": "GO:0004333 fumarate hydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006106 fumarate metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006281 DNA repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SX99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXE8-1", "uniprot_id": "CDK9_DANRE", "mass": 43131.0, "length": 374, "protein_name": "Cyclin-dependent kinase 9", "gene_name": "cdk9", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 9", "refseq_ac": "NP_997756", "gene_names_uniprotkb": "cdk9; wu:fb22e09; wu:fc06c02", "gene_names_refseq": "cdk9; wu:fb22e09; wu:fc06c02", "protein_names_uniprotkb": "Cyclin-dependent kinase 9; 2.7.11.22; 2.7.11.23; Cell division protein kinase 9", "protein_names_refseq": "cell division protein kinase 9; cyclin-dependent kinase 9", "tax_id": 7955, "disease": "renal carcinoma (Disease Ontology:DOID:4451); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:321602); (R-DRE-674695); (R-DRE-6796648); (R-DRE-6807505); (R-DRE-75955); (R-DRE-9018519)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "23594743;26542022;34523672;38589534", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF268046.1, GDQH01008629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) polr2a, supt5h and rdbp. This complex is inactive when in the 7SK snRNP complex form. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export., [UniProtKB, UniProtKB]; Selective Cdk9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish., [RefSeq, PubMed]; Transcription bodies regulate gene expression by sequestering CDK9., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4II91;Q7T3L5", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.7.6;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;3.1.3.16;2.7.4.3;3.1.27.-;5.6.2.4", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0061026 cardiac muscle tissue regeneration;GO:0030852 regulation of granulocyte differentiation;GO:0006281 DNA repair;GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7SXE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SXM7-1", "uniprot_id": "PRP31_DANRE", "mass": 56474.0, "length": 508, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp31", "gene_name": "prpf31", "organism": "Zebrafish", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp31", "refseq_ac": "NP_956798", "gene_names_uniprotkb": "prpf31; zgc:66177", "gene_names_refseq": "prpf31; zgc:66177", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31", "protein_names_refseq": "U4/U6 small nuclear ribonucleoprotein Prp31; pre-mRNA-processing factor 31", "tax_id": 7955, "disease": "retinitis pigmentosa 11 (Disease Ontology:DOID:0110408); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "33476374;38382674", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01000956.1, GFIL01031521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jul 2, 2025 this sequence version replaced XP_073780821.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing., [RefSeq, PubMed]; The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030622 U4atac snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0015030 Cajal body;GO:0071339 MLL1 complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0060041 retina development in camera-type eye;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7SXM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SYK7-1", "uniprot_id": "AATM_DANRE", "mass": 47587.0, "length": 428, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "got2a", "organism": "Zebrafish", "refseq_name": "aspartate aminotransferase, mitochondrial", "refseq_ac": "NP_998544", "gene_names_uniprotkb": "got2a; got2; zgc:66329", "gene_names_refseq": "got2a; got2; mAspAT; zgc:66329", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; 2.6.1.7; Glutamate oxaloacetate transaminase 2a; Glutamic-oxaloacetic transaminase 2a, mitochondrial; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Transaminase A; mAspAT", "protein_names_refseq": "aspartate aminotransferase, mitochondrial; glutamate oxaloacetate transaminase 2a; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; transaminase A", "tax_id": 7955, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 82 (Disease Ontology:DOID:0080715); neurodegenerative disease (Disease Ontology:DOID:1289); acute kidney failure (Disease Ontology:DOID:3021); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:406688)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;31422819;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054684.1, BC165803.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054684.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.4.1.13;2.6.1.63;2.6.1.7;2.6.1.39;2.6.1.4;2.6.1.73;2.6.1.1", "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0006533 L-aspartate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7SYK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZC2-1", "uniprot_id": "XPO2_DANRE", "mass": 110028.0, "length": 971, "protein_name": "Exportin-2", "gene_name": "cse1l", "organism": "Zebrafish", "refseq_name": "exportin-2", "refseq_ac": "NP_958858", "gene_names_uniprotkb": "cse1l; xpo2", "gene_names_refseq": "cas; cse1l", "protein_names_uniprotkb": "Exportin-2; Chromosome segregation 1-like protein; Exp2; Importin-alpha re-exporter", "protein_names_refseq": "baobab; bao; cellular apoptosis susceptibility; cellular apoptosis susceptibilit; chromosome segregation 1-like protein; exp2; exportin-2; importin-alpha re-exporter", "tax_id": 7955, "disease": "", "pathway": " (dre:30707)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20933420;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC052479.1, BC066737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC052479.1., [RefSeq]; Cse1l is a negative regulator of cystic fibrosis transmembrane conductance regulator-dependent fluid secretion. Erratum:[Curr Biol. 2010 Dec 7;20(23):2157], [RefSeq, PubMed]; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by down-regulating cftr activity (PubMed:20933420)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G1K2H9", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0007589 body fluid secretion;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7SZC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7SZS1-1", "uniprot_id": "SX21A_DANRE", "mass": 26528.0, "length": 239, "protein_name": "Transcription factor Sox-21-A", "gene_name": "sox21a", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-21-A", "refseq_ac": "NP_571361", "gene_names_uniprotkb": "sox21a; sox21; sox30", "gene_names_refseq": "SRY-box; sox21a; sox21; sox25; sox30", "protein_names_uniprotkb": "Transcription factor Sox-21-A; SRY-box containing gene 21a", "protein_names_refseq": "SRY (sex determining region Y)-box 21a; SRY-box containing gene 25; transcription factor Sox-21-A", "tax_id": 7955, "disease": "", "pathway": " (dre:30543)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10370117;10559493;11071752;15037315;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF101266.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF101266.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo., [UniProtKB, PubMed, UniProtKB]; Sox21a acts as a repressor in dorso-ventral patterning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q804S0;Q9PVF6;Q9YH21", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7SZS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T1H5-1", "uniprot_id": "DND1_DANRE", "mass": 46020.0, "length": 411, "protein_name": "Dead end protein 1", "gene_name": "dnd", "organism": "Zebrafish", "refseq_name": "dead end protein 1", "refseq_ac": "NP_997960", "gene_names_uniprotkb": "dnd", "gene_names_refseq": "cb736; dnd1; dnd; wu:fi22d10; zgc:111864", "protein_names_uniprotkb": "Dead end protein 1", "protein_names_refseq": "dead end protein 1; drDnd1", "tax_id": 7955, "disease": "teratocarcinoma (Disease Ontology:DOID:3305)", "pathway": " (dre:373074)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12932328;18155131;37463577", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY225448.1, BC095578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY225448.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Knockdown of dead end blocks confinement of primordial germ cells (PGCs) to the deep blastoderm shortly after their specification and results in failure of PGCs to exhibit motile behavior and to actively migrate thereafter., [RefSeq, PubMed]; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development., [UniProtKB, PubMed, PubMed]; Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBK4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043186 P granule;GO:0043073 germ cell nucleus", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0010628 positive regulation of gene expression;GO:0048255 mRNA stabilization;GO:2000145 regulation of cell motility;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T1H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2C4-1", "uniprot_id": "S26A5_DANRE", "mass": 81405.0, "length": 739, "protein_name": "Prestin", "gene_name": "slc26a5", "organism": "Zebrafish", "refseq_name": "prestin", "refseq_ac": "NP_958881", "gene_names_uniprotkb": "slc26a5; fb73d12; fb74g12; pres; wu:fb73d12; wu:fb74g12", "gene_names_refseq": "fb73d12; fb74g12; pres; slc26a5; wu:fb73d12; wu:fb74g12", "protein_names_uniprotkb": "Prestin; Solute carrier family 26 member 5", "protein_names_refseq": "prestin; solute carrier family 26 (anion exchanger), member 5; zprestin", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 61 (Disease Ontology:DOID:0110513); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (R-DRE-427601)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17272340;17442754;22399806;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054604.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054604.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Compared with mammalian prestin, charge movements mediated by zprestin display a weaker voltage dependence and slower kinetics; they occur at more positive membrane voltages, and are not associated with electromotile responses., [RefSeq, PubMed]; Electrogenic antiporter that exchanges sulfate or oxalate for chloride ion in a strictly coupled manner with a 1:1 stoichiometry (PubMed:17442754, PubMed:22399806). Adopts a dynamic conformation, which alternates between the exposure of the central binding site to the extra- and intracellular solutions leading to an inward-to-outward conformational transition during the transport cycle (By similarity). Generates voltage-dependent charge movements resembling to the non-linear capacitance (NLC) of the cell membrane, but which are not associated to electromotile activity (PubMed:17272340, PubMed:22399806)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Sequence conservation between mammalian and nonmammalian prestin together with a common pharmacology of electromotility and divalent antiport, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PEF9", "ec_number_list": "", "go_molecular_function": "GO:0015499 formate transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0042391 regulation of membrane potential;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T2C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T394-1", "uniprot_id": "LIS1A_DANRE", "mass": 46513.0, "length": 410, "protein_name": "Lissencephaly-1 homolog A", "gene_name": "pafah1b1a", "organism": "Zebrafish", "refseq_name": "lissencephaly-1 homolog A", "refseq_ac": "NP_958502", "gene_names_uniprotkb": "pafah1b1a; lis1b; si:dkey-95O3.1", "gene_names_refseq": "pafah1b1a", "protein_names_uniprotkb": "Lissencephaly-1 homolog A; Platelet-activating factor acetylhydrolase IB subunit alpha a", "protein_names_refseq": "lis1b; lissencephaly-1 homolog A", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:394246); (R-DRE-1169091); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-2565942); (R-DRE-380320); (R-DRE-5607761); (R-DRE-5663220); (R-DRE-5676590); (R-DRE-5684264); (R-DRE-6811436); (R-DRE-69601); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "17785424;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053205.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053205.1., [RefSeq]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07DR1", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0051301 cell division;GO:0007281 germ cell development;GO:0048854 brain morphogenesis;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7T394-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3A4-1", "uniprot_id": "RAB13_DANRE", "mass": 22458.0, "length": 200, "protein_name": "Ras-related protein Rab-13", "gene_name": "rab13", "organism": "Zebrafish", "refseq_name": "ras-related protein Rab-13", "refseq_ac": "NP_958486", "gene_names_uniprotkb": "rab13", "gene_names_refseq": "cb764; hm:zeh0455; rab13", "protein_names_uniprotkb": "Ras-related protein Rab-13; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-13", "tax_id": 7955, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (dre:373105); (R-DRE-8873719)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21543326;23594743;32946121", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053195.1, EH543570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053195.1., [RefSeq]; RAB13 mRNA compartmentalisation spatially orients tissue morphogenesis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight junctions. May play a role in angiogenesis through regulation of endothelial cells chemotaxis. May be involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of glucose transporters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030027 lamellipodium;GO:0055037 recycling endosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T3A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3B2-1", "uniprot_id": "HRG1A_DANRE", "mass": 16627.0, "length": 144, "protein_name": "Heme transporter hrg1-A", "gene_name": "slc48a1b", "organism": "Zebrafish", "refseq_name": "heme transporter hrg1-A", "refseq_ac": "NP_956300", "gene_names_uniprotkb": "slc48a1b; hrg1a; zgc:63994", "gene_names_refseq": "fj61c11; hrg1; slc48a1b; wu:fj61c11; zgc:63994", "protein_names_uniprotkb": "Heme transporter hrg1-A; HRG-1A; Heme-responsive gene 1 protein homolog A; Solute carrier family 48 member 1-B; zHRG-1", "protein_names_refseq": "HRG-1A; heme responsive gene 1; heme transporter hrg1-A; heme-responsive gene 1 protein homolog A; hrg-1; solute carrier family 48 (heme transporter), member 1b; solute carrier family 48 member 1-B; zHRG-1", "tax_id": 7955, "disease": "", "pathway": " (dre:792763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18418376;23395172;30248094", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053186.1, CK030183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053186.1. On or before Dec 21, 2007 this sequence version replaced XP_001332277.1, XP_001332358.1, XP_001332618.1, XP_001332701.1., [RefSeq]; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages, is the heme transporter for heme-iron recycling (PubMed:18418376). Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP) (PubMed:23395172)., [UniProtKB, PubMed, PubMed]; Study results show that zebrafish Hrg1a and its paralog Hrg1b are functional heme transporters, and genetic ablation of both transporters in double knockout animals shows lower iron accumulation concomitant with higher amounts of heme sequestered in kidney macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and, most strikingly, profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8KBS4", "ec_number_list": "", "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0030670 phagocytic vesicle membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0015886 heme transport;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T3B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3I0-1", "uniprot_id": "ZC4H2_DANRE", "mass": 26212.0, "length": 224, "protein_name": "Zinc finger C4H2 domain-containing protein", "gene_name": "zc4h2", "organism": "Zebrafish", "refseq_name": "zinc finger C4H2 domain-containing protein", "refseq_ac": "NP_955936", "gene_names_uniprotkb": "zc4h2", "gene_names_refseq": "wu:fb99f08; zc4h2; zgc:63849", "protein_names_uniprotkb": "Zinc finger C4H2 domain-containing protein; Hepatocellular carcinoma-associated antigen 127 homolog; Hepatocellular carcinoma-associated antigen 127-like", "protein_names_refseq": "hepatocellular carcinoma-associated antigen 127 homolog; un-named hi2729b; unm hi2729b; zinc finger C4H2 domain-containing protein", "tax_id": 7955, "disease": "Wieacker-Wolff syndrome (Disease Ontology:DOID:0060815); female-restricted Wieacker-Wolff syndrome (Disease Ontology:DOID:0061015); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:323487)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15256591;23594743;23623388;26056227;36250278", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053110.1, EH450490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476800 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053110.1. On Jul 6, 2005 this sequence version replaced XP_689608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Antisense-morpholino-mediated zc4h2 knockdown caused abnormal swimming and impaired alpha-motoneuron development., [RefSeq, PubMed]; Expanding allelic and phenotypic spectrum of ZC4H2-related disorder: A novel hypomorphic variant and high prevalence of tethered cord., [RefSeq, PubMed]; Plays a role in GABAergic and V2 interneurons differentiation (PubMed:26056227). Involved in motoneuron development and in neuromuscular junction formation (PubMed:23623388)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0007528 neuromuscular junction development;GO:0045666 positive regulation of neuron differentiation;GO:0050885 neuromuscular process controlling balance;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7T3I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3T8-1", "uniprot_id": "ZAR1_DANRE", "mass": 38256.0, "length": 329, "protein_name": "Zygote arrest protein 1", "gene_name": "zar1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "zar1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zygote arrest protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12773403;27913641", "class_list": "", "function": "mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:27913641). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of zona pellucida mRNAs, inhibiting their translation (PubMed:27913641)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030371 translation repressor activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0001556 oocyte maturation;GO:1905881 positive regulation of oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T3T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZSX3-1", "uniprot_id": "PTF1A_DANRE", "mass": 30447.0, "length": 265, "protein_name": "Pancreas transcription factor 1 subunit alpha", "gene_name": "ptf1a", "organism": "Zebrafish", "refseq_name": "pancreas transcription factor 1 subunit alpha", "refseq_ac": "NP_997524", "gene_names_uniprotkb": "ptf1a; si:zc142h2.2; zgc:112216", "gene_names_refseq": "PTF1; ptf1a; si:zc142h2.2; zgc:112216", "protein_names_uniprotkb": "Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; bHLH transcription factor p48", "protein_names_refseq": "Ptfa; bHLH transcription factor p48; pancreas specific transcription factor, 1a; pancreas transcription factor 1 subunit alpha", "tax_id": 7955, "disease": "pancreatic agenesis 2 (Disease Ontology:DOID:0060988)", "pathway": " (dre:368662)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15031114;15183727;15280211;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093269.1, AY245546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093269.1. On Mar 11, 2007 this sequence version replaced XP_698374.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mapping, analysis of embryonic expression and role in pancreas development Erratum:[Dev Biol. 2004 Jun 1;270(1):274], [RefSeq, PubMed]; Ptf1 function is inhibited by notch, [RefSeq, PubMed]; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZSX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTI3-1", "uniprot_id": "RARAB_DANRE", "mass": 50525.0, "length": 458, "protein_name": "Retinoic acid receptor alpha-B", "gene_name": "rarab", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor alpha-B", "refseq_ac": "NP_571474", "gene_names_uniprotkb": "rarab; nr1b1b; rara2b", "gene_names_refseq": "fj66e06; rara2b; rarab; wu:fj66e06", "protein_names_uniprotkb": "Retinoic acid receptor alpha-B; Nuclear receptor subfamily 1 group B member 1-B; RAR-alpha-2.B; RAR-alpha-B; Retinoic acid receptor alpha-2.B", "protein_names_refseq": "NR1B1-B; RAR-alpha-2.B; RAR-alpha-B; RARalpha-B; nr1b1b; nuclear receptor subfamily 1 group B member 1-B; retinoic acid receptor alpha b1; retinoic acid receptor alpha-2.B; retinoic acid receptor alpha-B; retinoic acid receptor, alpha 2b; zRAR-alpha-2.B", "tax_id": 7955, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); syndromic microphthalmia 12 (Disease Ontology:DOID:0111800); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (dre:555364); (R-DRE-383280); (R-DRE-5362517)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16455309;18929555", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049301.1, L03399.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049301.1. On or before Nov 27, 2007 this sequence version replaced XP_001342250.1, XP_682949.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90272", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZTI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTU9-1", "uniprot_id": "TBX2_DANRE", "mass": 75335.0, "length": 687, "protein_name": "T-box transcription factor TBX2b", "gene_name": "tbx2b", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX2b", "refseq_ac": "NP_571126", "gene_names_uniprotkb": "tbx2b; tbx-c", "gene_names_refseq": "hm:zeh1581; tbx-c; tbx2b; tbx2; tbxc; zeh1581", "protein_names_uniprotkb": "T-box transcription factor TBX2b; T-box protein 2b", "protein_names_refseq": "T-box 2b; T-box gene C; T-box protein 2b; T-box transcription factor TBX2b; fby; lor", "tax_id": 7955, "disease": "vertebral anomalies and variable endocrine and T-cell dysfunction (Disease Ontology:DOID:0070345); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); heart septal defect (Disease Ontology:DOID:1681); atrial heart septal defect (Disease Ontology:DOID:1882)", "pathway": " (dre:30253)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10331981;10664151;15755805;16033799;18347092", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF179405.1, BC051603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF179405.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cellular mechanisms regulating neuronal differentiation within the retina are asymmetric about the dorsal/ventral axis, and Tbx2b mediates this process within the dorsal retina, [RefSeq, PubMed]; Data show that tbx2b transcripts are present during mid-gastrula before its expression is detected by whole-mount in situ hybridization., [RefSeq, PubMed]; Transcription factor which acts as a transcriptional repressor (By similarity). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9IAL0;Q9W7B7", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0048484 enteric nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZTU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU99-1", "uniprot_id": "TERA_DANRE", "mass": 89424.0, "length": 806, "protein_name": "Transitional endoplasmic reticulum ATPase", "gene_name": "vcp", "organism": "Zebrafish", "refseq_name": "transitional endoplasmic reticulum ATPase", "refseq_ac": "NP_958889", "gene_names_uniprotkb": "vcp; cdc48; si:ch211-113n10.2", "gene_names_refseq": "CDC48; vcp; wu:fd16d05; wu:fj63d11", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase; 3.6.4.6; Protein CDC48; TER ATPase; VCP; Valosin-containing protein", "protein_names_refseq": "protein CDC48; transitional endoplasmic reticulum ATPase", "tax_id": 7955, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (Disease Ontology:DOID:0060205); Charcot-Marie-Tooth disease type 2Y (Disease Ontology:DOID:0110168); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 (Disease Ontology:DOID:0111385); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); inclusion body myositis (Disease Ontology:DOID:3429); Paget's disease of bone (Disease Ontology:DOID:5408); primary ovarian insufficiency (Disease Ontology:DOID:5426); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (dre:327197); (R-DRE-110320); (R-DRE-3371511); (R-DRE-382556); (R-DRE-532668); (R-DRE-5358346); (R-DRE-5689877); (R-DRE-5689896); (R-DRE-6798695); (R-DRE-8876725); (R-DRE-8951664); (R-DRE-9013407); (R-DRE-9755511); (R-DRE-9931269)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "12914916;15520368;18307296;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050488.1, BC067384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050488.1. On Jul 6, 2005 this sequence version replaced XP_702509.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells, [RefSeq, PubMed]; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Together with sprtn metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (By similarity). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of RIGI (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity). May more particularly play a role in caveolins sorting in cells (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q76KA4", "ec_number_list": "3.4.24.-;2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;2.7.1.11;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;3.4.21.4;3.4.19.12;2.7.1.40;2.4.1.1;3.1.27.-;2.7.11.1;1.1.1.205;5.6.2.-;5.4.2.11;5.4.2.4;2.7.1.35;1.13.11.34;4.6.1.19;3.5.3.1;2.7.7.7;2.7.7.49;3.2.1.-;2.3.2.36;3.2.1.31;5.3.4.1;5.6.2.5;3.1.6.4;3.5.4.4;3.6.5.-;3.5.1.52;3.1.3.16;6.3.4.21;5.3.99.3;3.6.1.-;1.6.5.5;4.1.2.13;3.1.-.-;2.7.11.24;1.11.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1905634 regulation of protein localization to chromatin;GO:0006281 DNA repair;GO:0007626 locomotory behavior;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7ZU99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUQ3-1", "uniprot_id": "STK3_DANRE", "mass": 56081.0, "length": 492, "protein_name": "Serine/threonine-protein kinase 3", "gene_name": "stk3", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase 3", "refseq_ac": "NP_955966", "gene_names_uniprotkb": "stk3; zgc:55383", "gene_names_refseq": "stk3; wu:fc19e11; zgc:55383", "protein_names_uniprotkb": "Serine/threonine-protein kinase 3; 2.7.11.1", "protein_names_refseq": "mst2; serine/threonine-protein kinase 3", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:324125); (R-DRE-2028269)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "32439761;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048033.1, BC164215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC048033.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Core Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network. Publication Status: Online-Only, [RefSeq, PubMed]; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0051262 protein tetramerization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZUQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUS1-1", "uniprot_id": "VRK1_DANRE", "mass": 47771.0, "length": 425, "protein_name": "Serine/threonine-protein kinase VRK1", "gene_name": "vrk1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase VRK1", "refseq_ac": "NP_998550", "gene_names_uniprotkb": "vrk1; zgc:56266", "gene_names_refseq": "vrk1; wu:fe16f06; zgc:56266", "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK1; 2.7.11.1; Vaccinia-related kinase 1", "protein_names_refseq": "serine/threonine-protein kinase VRK1; vaccinia related kinase 1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 1A (Disease Ontology:DOID:0060265); autosomal recessive distal hereditary motor neuronopathy 10 (Disease Ontology:DOID:0081429)", "pathway": " (dre:406694); (R-DRE-2995383)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "37429068;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047853.1, BC152280.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047853.1., [RefSeq]; Behavioral and neurological effects of Vrk1 deficiency in zebrafish., [RefSeq, PubMed]; Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (By similarity). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (By similarity). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (By similarity). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (By similarity). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (By similarity). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2. Phosphorylates ATF2 which activates its transcriptional activity. Phosphorylates JUN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005795 Golgi stack;GO:0015030 Cajal body", "go_biological_process": "GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZUS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUS4-1", "uniprot_id": "ST2S2_DANRE", "mass": 35364.0, "length": 301, "protein_name": "Cytosolic sulfotransferase 2", "gene_name": "sult1st2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "sult1st2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic sulfotransferase 2; 2.8.2.-; SULT1 ST2", "protein_names_refseq": "", "tax_id": 7955, "disease": "endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (R-DRE-156584); (R-DRE-9753281)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12755695", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, T3 (triiodo-L-thyronine), T4 (thyroxine), estrone and DOPA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T1C7", "ec_number_list": "2.8.2.-;2.8.2.n2", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004304 estrone sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation;GO:0006805 xenobiotic metabolic process;GO:0006584 catecholamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZUS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVA6-1", "uniprot_id": "IF4A3_DANRE", "mass": 46468.0, "length": 406, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "eif4a3", "organism": "Zebrafish", "refseq_name": "eukaryotic initiation factor 4A-III", "refseq_ac": "NP_957372", "gene_names_uniprotkb": "eif4a3; ddx48", "gene_names_refseq": "ddx48; eIF4A-III; eif4a3; zgc:56139", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3; eIF-4A-III; eIF4A-III", "protein_names_refseq": "ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF-4A-III; eukaryotic initiation factor 4A-III; eukaryotic initiation factor 4AIII", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:394053); (R-DRE-159236); (R-DRE-72163); (R-DRE-975957)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "24360810;33914867;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045939.1, BC165833.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045939.1., [RefSeq]; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (PubMed:24360810)., [UniProtKB, PubMed, UniProtKB]; Eukaryotic initiation factor 4A3 inhibits Wnt/beta-catenin signaling and regulates axis formation in zebrafish embryos., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.7.6;3.1.-.-;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.2.1.8;3.1.3.16;5.6.2.-;2.7.11.1;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:0009950 dorsal/ventral axis specification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZVA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVN5-1", "uniprot_id": "SRP54_DANRE", "mass": 55753.0, "length": 504, "protein_name": "Signal recognition particle subunit SRP54", "gene_name": "srp54", "organism": "Zebrafish", "refseq_name": "signal recognition particle subunit SRP54", "refseq_ac": "NP_957282", "gene_names_uniprotkb": "srp54", "gene_names_refseq": "Srp54k; srp54; zgc:55842; zgc:85713", "protein_names_uniprotkb": "Signal recognition particle subunit SRP54; 3.6.5.4; Signal recognition particle 54 kDa protein", "protein_names_refseq": "signal recognition particle 54 kDa protein; signal recognition particle subunit SRP54", "tax_id": 7955, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); severe congenital neutropenia 8 (Disease Ontology:DOID:0112135); neutropenia (Disease Ontology:DOID:1227)", "pathway": " (dre:393963); (R-DRE-1799339)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "23594743;28972538;33227812;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001085.1, GFIL01039678.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH550891.1, JBMGRA010000017.1 and EH461167.1. On Feb 27, 2016 this sequence version replaced XP_005158673.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component srpra to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit srpra. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of srp9/srp14 and/or srp19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development., [UniProtKB, UniProtKB, UniProtKB, PubMed]; SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030593 neutrophil chemotaxis;GO:0031017 exocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZVN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW00-1", "uniprot_id": "AGK_DANRE", "mass": 47545.0, "length": 422, "protein_name": "Acylglycerol kinase, mitochondrial", "gene_name": "agk", "organism": "Zebrafish", "refseq_name": "acylglycerol kinase, mitochondrial precursor", "refseq_ac": "NP_956174", "gene_names_uniprotkb": "agk; mulk; si:ch211-238n5.3; zgc:55462", "gene_names_refseq": "agk; fi38e09; mulk; wu:fi38e09; zgc:55462", "protein_names_uniprotkb": "Acylglycerol kinase, mitochondrial; 2.7.1.107; 2.7.1.138; 2.7.1.94; MuLK; Multi-substrate lipid kinase; Multiple substrate lipid kinase", "protein_names_refseq": "acylglycerol kinase, mitochondrial precursor; acylglycerol kinase, mitochondrial; multi-substrate lipid kinase; multiple substrate lipid kinase", "tax_id": 7955, "disease": "Sengers syndrome (Disease Ontology:DOID:0080132); cataract 38 (Disease Ontology:DOID:0110245)", "pathway": " (dre:334270); (R-DRE-1483206)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045347.1, BC152233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045347.1., [RefSeq]; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (By similarity). Phosphorylates ceramide but not sphingosine (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LX48", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0001729 ceramide kinase activity;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0047620 acylglycerol kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZW00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWB7-1", "uniprot_id": "BBS5_DANRE", "mass": 38915.0, "length": 342, "protein_name": "BBSome complex member BBS5", "gene_name": "bbs5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "bbs5; zgc:56578", "gene_names_refseq": "", "protein_names_uniprotkb": "BBSome complex member BBS5; Bardet-Biedl syndrome 5 protein homolog", "protein_names_refseq": "", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 5 (Disease Ontology:DOID:0110127); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (dre:393269); (R-DRE-5620922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0060170 ciliary membrane;GO:0034464 BBSome", "go_biological_process": "GO:0060271 cilium assembly;GO:0001947 heart looping;GO:0070121 Kupffer's vesicle development;GO:0007369 gastrulation;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWE9-1", "uniprot_id": "KCY_DANRE", "mass": 22423.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "cmpk", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "cmpk; CK; CMPK1; CMPK; cmpk1; fb52d08; fk47a07; ump; wu:fb52d08; wu:fk47a07; zgc:56452", "gene_names_refseq": "", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dre:406383); (R-DRE-499943)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26469318;28252024;40044042", "class_list": "", "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.4.3;2.7.4.6;2.7.4.9;2.7.4.14", "go_molecular_function": "GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process;GO:0006221 pyrimidine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZWE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWG9-1", "uniprot_id": "SGMR1_DANRE", "mass": 24941.0, "length": 222, "protein_name": "Sigma non-opioid intracellular receptor 1", "gene_name": "sigmar1", "organism": "Zebrafish", "refseq_name": "sigma non-opioid intracellular receptor 1", "refseq_ac": "NP_957271", "gene_names_uniprotkb": "sigmar1; oprs1; zgc:56378", "gene_names_refseq": "oprs1; sigmar1; zgc:56378", "protein_names_uniprotkb": "Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R", "protein_names_refseq": "opioid receptor, sigma 1; sigma 1-type opioid receptor; sigma non-opioid intracellular receptor 1; sigma1-receptor; sigma1R", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); amyotrophic lateral sclerosis type 16 (Disease Ontology:DOID:0060207); autosomal recessive distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111065); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:393952)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049416.1, EH547225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049416.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0006869 lipid transport;GO:0009611 response to wounding;GO:0046548 retinal rod cell development;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZWG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q800H9-1", "uniprot_id": "H6ST2_DANRE", "mass": 54605.0, "length": 468, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 2", "gene_name": "hs6st2", "organism": "Zebrafish", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 2", "refseq_ac": "NP_919402", "gene_names_uniprotkb": "hs6st2; fb80f12; hs6st; wu:fb80f12", "gene_names_refseq": "fb80f12; hs6st2; hs6st; wu:fb80f12", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 2; 2.8.2.-; HS 6-OST-2; HS6ST-2", "protein_names_refseq": "HS 6-OST-2; HS6ST-2; heparan-sulfate 6-O-sulfotransferase 2", "tax_id": 7955, "disease": "Paganini-Miozzo syndrome (Disease Ontology:DOID:0111843)", "pathway": " (dre:378450); (R-DRE-2022928)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12782624;16009360;17075883", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065683.1, AJ505990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC065683.1, CF998149.1, CT663102.2, FP119371.1, GFIL01012862.1 and BM571478.1. On Aug 8, 2023 this sequence version replaced NP_919402.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Hs6st2 is required for the branching morphogenesis of the caudal vein during embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0MGZ6;Q6P0B4;Q7ZVQ5", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0048048 embryonic eye morphogenesis;GO:0001569 branching involved in blood vessel morphogenesis;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q800H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q801E0-1", "uniprot_id": "VAX1_DANRE", "mass": 33940.0, "length": 317, "protein_name": "Ventral anterior homeobox 1", "gene_name": "vax1", "organism": "Zebrafish", "refseq_name": "ventral anterior homeobox 1", "refseq_ac": "NP_919391", "gene_names_uniprotkb": "vax1", "gene_names_refseq": "vax1", "protein_names_uniprotkb": "Ventral anterior homeobox 1", "protein_names_refseq": "ventral anterior homeobox 1", "tax_id": 7955, "disease": "syndromic microphthalmia 11 (Disease Ontology:DOID:0111804)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12538521", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065951.1, AY185348.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476734, SAMEA4476741 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065951.1. On Jun 26, 2005 this sequence version replaced NP_919391.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup., [UniProtKB, PubMed]; Vax1 and vax2 are expressed in overlapping domains encompassing the ventral retina, optic stalks and preoptic area; Hh signals act downstream of the Nodal pathway to promote Vax gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZV9", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0061386 closure of optic fissure;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q801E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q801E1-1", "uniprot_id": "VAX2_DANRE", "mass": 33156.0, "length": 307, "protein_name": "Ventral anterior homeobox 2", "gene_name": "vax2", "organism": "Zebrafish", "refseq_name": "ventral anterior homeobox 2", "refseq_ac": "NP_919390", "gene_names_uniprotkb": "vax2", "gene_names_refseq": "vax2", "protein_names_uniprotkb": "Ventral anterior homeobox 2", "protein_names_refseq": "ventral anterior homeobox 2", "tax_id": 7955, "disease": "", "pathway": " (dre:373869)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12538521", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY183363.1, BC163223.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476779, SAMEA4476799 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY183363.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup., [UniProtKB, PubMed]; Vax1 and vax2 are expressed in overlapping domains encompassing the ventral retina, optic stalks and preoptic area; Hh signals act downstream of the Nodal pathway to promote Vax gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0061386 closure of optic fissure;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q801E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q801G2-1", "uniprot_id": "MPRAB_DANRE", "mass": 41383.0, "length": 354, "protein_name": "Membrane progestin receptor alpha-B", "gene_name": "paqr7b", "organism": "Zebrafish", "refseq_name": "membrane progestin receptor alpha-B", "refseq_ac": "NP_899188", "gene_names_uniprotkb": "paqr7b; mpra; paqr7", "gene_names_refseq": "mpra2; mpra; paqr7b; paqr7", "protein_names_uniprotkb": "Membrane progestin receptor alpha-B; Progestin and adipoQ receptor family member VII, b; mPR alpha", "protein_names_refseq": "PR alpha; mPR alpha; membrane progestin receptor alpha-B; membrane progestin receptor alpha", "tax_id": 7955, "disease": "", "pathway": " (dre:368256)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12574519;12601167;15862564;16899559", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY149121.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY149121.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Progestin receptor mediates a nonclassical action of progestins to induce oocyte maturation in fish, [RefSeq, PubMed]; Steroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0043401 steroid hormone receptor signaling pathway;GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q801G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802V6-1", "uniprot_id": "ABH2A_DANRE", "mass": 48673.0, "length": 432, "protein_name": "Monoacylglycerol lipase ABHD2", "gene_name": "abhd2a", "organism": "Zebrafish", "refseq_name": "monoacylglycerol lipase ABHD2", "refseq_ac": "NP_957208", "gene_names_uniprotkb": "abhd2a; abhd2; zgc:55722", "gene_names_refseq": "abhd2a; abhd2; zgc:55722", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD2; 2-arachidonoylglycerol hydrolase; 3.1.1.23; 3.1.1.6; 3.1.1.79; Abhydrolase domain-containing protein 2-A; Acetylesterase; Triacylglycerol lipase", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain containing 2a; abhydrolase domain-containing protein 2-A; acetylesterase; monoacylglycerol lipase ABHD2-A; monoacylglycerol lipase ABHD2; triacylglycerol lipase", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047183.1. On Jul 6, 2005 this sequence version replaced XP_702398.1., [RefSeq]; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.34;3.1.1.-;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.3;3.1.1.5;3.3.2.9;3.1.1.116;3.1.1.6;3.1.-.-", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0004806 triacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0046464 acylglycerol catabolic process;GO:0032570 response to progesterone;GO:0043401 steroid hormone receptor signaling pathway;GO:0048240 sperm capacitation;GO:0051793 medium-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q802V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803C1-1", "uniprot_id": "RNF8_DANRE", "mass": 55325.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase rnf8", "gene_name": "rnf8", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase rnf8 isoform 1", "refseq_ac": "NP_991116", "gene_names_uniprotkb": "rnf8; zgc:55936", "gene_names_refseq": "fc66f09; rnf8; wu:fc66f09; zgc:55936; zgc:77313", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf8; 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase rnf8", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase rnf8 isoform 1; RING-type E3 ubiquitin transferase rnf8; ring finger protein (C3HC4 type) 8", "tax_id": 7955, "disease": "", "pathway": " (dre:404050); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065643.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065643.1., [RefSeq]; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0F2", "ec_number_list": "2.1.1.354;2.7.11.1;1.14.11.66;2.3.2.27;3.1.3.16;3.1.-.-;2.3.2.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0000151 ubiquitin ligase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803C3-1", "uniprot_id": "HDAC3_DANRE", "mass": 48980.0, "length": 428, "protein_name": "Histone deacetylase 3", "gene_name": "hdac3", "organism": "Zebrafish", "refseq_name": "histone deacetylase 3", "refseq_ac": "NP_957284", "gene_names_uniprotkb": "hdac3; zgc:55927", "gene_names_refseq": "hdac3; zgc:55927", "protein_names_uniprotkb": "Histone deacetylase 3; 3.5.1.-; 3.5.1.98; HD3; Protein deacetylase HDAC3; Protein deacylase HDAC3", "protein_names_refseq": "HD3; histone deacetylase 3; protein deacetylase HDAC3; protein deacylase HDAC3", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrahepatic cholestasis of pregnancy (Disease Ontology:DOID:0070227); prostate carcinoma (Disease Ontology:DOID:10286); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:393965); (R-DRE-400206); (R-DRE-9707564)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18367159", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044543.1. On Jan 31, 2008 this sequence version replaced XP_001336978.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as a deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl), 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) and isonicotinyl acyl groups from lysine residues, leading to protein decrotonylation, delactylation, de-2-hydroxyisobutyrylation and deisonicotinylation, respectively., [UniProtKB, UniProtKB]; These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;2.1.1.319;3.5.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0004407 histone deacetylase activity;GO:0033558 protein lysine deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803D2-1", "uniprot_id": "LIS1B_DANRE", "mass": 46530.0, "length": 410, "protein_name": "Lissencephaly-1 homolog B", "gene_name": "pafah1b1b", "organism": "Zebrafish", "refseq_name": "lissencephaly-1 homolog B", "refseq_ac": "NP_958503", "gene_names_uniprotkb": "pafah1b1b; lis1a", "gene_names_refseq": "Lis1a; pafah1b1b", "protein_names_uniprotkb": "Lissencephaly-1 homolog B; Platelet-activating factor acetylhydrolase IB subunit alpha b", "protein_names_refseq": "lissencephaly-1 homolog B", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:394247)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17785424", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044530.1. Sequence Note: This sequence has been modified as follows: removed 28 bp suspected to be vector contamination from the 5' end., [RefSeq]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells., [UniProtKB, UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07DR2", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0051301 cell division;GO:0045494 photoreceptor cell maintenance;GO:0007281 germ cell development;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q803D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q804T6-1", "uniprot_id": "DIX1A_DANRE", "mass": 50439.0, "length": 443, "protein_name": "Dixin-A", "gene_name": "dixdc1a", "organism": "Zebrafish", "refseq_name": "dixin-A", "refseq_ac": "NP_878304", "gene_names_uniprotkb": "dixdc1a; ccd1; dixdc1", "gene_names_refseq": "ccd1; dixdc1a; dixdc1", "protein_names_uniprotkb": "Dixin-A; Coiled-coil protein DIX1-A; Coiled-coil-DIX1-A; DIX domain-containing protein 1-A", "protein_names_refseq": "DIX domain containing 1; DIX domain-containing protein 1-A; DIX domain-containing protein 1; coiled-coil DIX 1; coiled-coil protein DIX1-A; coiled-coil protein DIX1; coiled-coil-DIX1-A; coiled-coil-DIX1; dixin-A; dixin", "tax_id": 7955, "disease": "", "pathway": " (dre:360137)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12526749", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF502143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF502143.1., [RefSeq]; Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning., [UniProtKB, PubMed]; These results indicate that Ccd1 is a novel positive regulator in this Wnt signaling pathway during zebrafish neural patterning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0030900 forebrain development;GO:0060070 canonical Wnt signaling pathway;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q804T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AW52-1", "uniprot_id": "ATOH7_DANRE", "mass": 15622.0, "length": 134, "protein_name": "Transcription factor atoh7", "gene_name": "atoh7", "organism": "Zebrafish", "refseq_name": "transcription factor atoh7", "refseq_ac": "NP_571707", "gene_names_uniprotkb": "atoh7; ath5; lak; si:packtrz.1", "gene_names_refseq": "ath5; atoh7; zath5", "protein_names_uniprotkb": "Transcription factor atoh7; Atonal bHLH transcription factor 7; Helix-loop-helix protein zATH-5; Protein atonal homolog 5; Protein atonal homolog 7; Protein lakritz; zATH5", "protein_names_refseq": "helix-loop-helix protein zATH-5; protein atonal homolog 5; protein atonal homolog 7; protein lakritz; transcription factor atoh7", "tax_id": 7955, "disease": "persistent hyperplastic primary vitreous (Disease Ontology:DOID:0060282)", "pathway": " (dre:58216)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10985346;11430806;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB049457.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB049457.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development (PubMed:10985346, PubMed:11430806). Required for retinal circadian rhythm photoentrainment (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DGA9", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0043204 perikaryon", "go_biological_process": "GO:0003407 neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8AW52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AWD2-1", "uniprot_id": "MOCS3_DANRE", "mass": 50798.0, "length": 459, "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3", "gene_name": "mocs3", "organism": "Zebrafish", "refseq_name": "adenylyltransferase and sulfurtransferase MOCS3", "refseq_ac": "NP_956421", "gene_names_uniprotkb": "mocs3; MOCS3; UBA4; uba4; zgc:55696", "gene_names_refseq": "mocs3; zgc:55696", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; Molybdenum cofactor synthesis protein 3; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3", "protein_names_refseq": "adenylyltransferase and sulfurtransferase MOCS3", "tax_id": 7955, "disease": "", "pathway": " (dre:393095); (R-DRE-947581)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC042324.1, GFIL01026625.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jul 28, 2025 this sequence version replaced NP_956421.1., [RefSeq]; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity)., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQE7", "ec_number_list": "2.7.7.80;2.8.1.11", "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8AWD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AWW7-1", "uniprot_id": "RUVB1_DANRE", "mass": 50367.0, "length": 456, "protein_name": "RuvB-like 1", "gene_name": "ruvbl1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ruvbl1", "gene_names_refseq": "", "protein_names_uniprotkb": "RuvB-like 1; 3.6.4.12; Pontin; zPontin", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-201722); (R-DRE-5689603); (R-DRE-5689880); (R-DRE-5696394)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12464178;40044042", "class_list": "", "function": "Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth (PubMed:12464178)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;3.4.19.12;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.4.-.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0060420 regulation of heart growth;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8AWW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AXB3-1", "uniprot_id": "VGFR4_DANRE", "mass": 146950.0, "length": 1302, "protein_name": "Vascular endothelial growth factor receptor kdr-like", "gene_name": "kdrl", "organism": "Zebrafish", "refseq_name": "vascular endothelial growth factor receptor kdr-like precursor", "refseq_ac": "NP_571547", "gene_names_uniprotkb": "kdrl; flk-1; flk1; flka; flk; kdra; kdr; si:ch211-276g21.4; vegfr-2; vegfr2a; vegfr2; vegfr4; vegr2; wu:fk52c05", "gene_names_refseq": "flk-1; flk1; flk; kdra; kdrl; kdr; vegfr-2; vegfr2a; vegfr2; vegfr4; vegr2; wu:fk52c05", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor kdr-like; 2.7.10.1; FLK-1; Fetal liver kinase 1; Kinase insert domain receptor-A; Kinase insert domain receptor-like; Protein-tyrosine kinase receptor flk-1; VEGFR-4; Vascular endothelial growth factor receptor 4", "protein_names_refseq": "VEGFR-4; fetal liver kinase 1; flt1b; kinase insert domain receptor-A; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 4; vascular endothelial growth factor receptor kdr-like precursor; vascular endothelial growth factor receptor kdr-like; vascular endothelial growth factor receptor type 2", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (dre:796537); (R-DRE-194306); (R-DRE-195399); (R-DRE-4420097); (R-DRE-5218921)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "12086862;12194822;16617120;17698971;17722983;18296487;18516225;23594743;9053314;9119113;9178253;9630750", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY056466.1, BC129158.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY056466.1. On or before Nov 28, 2007 this sequence version replaced XP_001336894.1, XP_001337611.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 19, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A1L1P1;B0R127;O42377;P79743;Q8UUW9;Q98891;Q9PTL0", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.11.24;2.7.1.137", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8AXB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JGS1-1", "uniprot_id": "STIL_DANRE", "mass": 138246.0, "length": 1263, "protein_name": "SCL-interrupting locus protein homolog", "gene_name": "stil", "organism": "Zebrafish", "refseq_name": "SCL-interrupting locus protein homolog", "refseq_ac": "NP_775351", "gene_names_uniprotkb": "stil; chunp6907; csp; nbb; sill; zgc:110502", "gene_names_refseq": "chunp6907; csp; nbb; sill; stil; zgc:110502", "protein_names_uniprotkb": "SCL-interrupting locus protein homolog", "protein_names_refseq": "SCL-interrupting locus protein homolog; TAL1 (SCL) interrupting locus like; cassiopeia; scl/tal1 interrupting locus", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 7 (Disease Ontology:DOID:0070278); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:192317)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12006978;17090656;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091991.1, AY099525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1, EH591838.1 and BM530920.1. On Sep 1, 2015 this sequence version replaced NP_775351.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays an essential role in early embryonic development (PubMed:12006978). Plays an important role in the regulation of centriole duplication and directional cell motility (By similarity)., [UniProtKB, PubMed, UniProtKB]; Scl/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LV59;Q58EB7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0005815 microtubule organizing center;GO:0005814 centriole", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:1905832 positive regulation of spindle assembly;GO:0010171 body morphogenesis;GO:0070050 neuron cellular homeostasis;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JGS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHF2-1", "uniprot_id": "LFNG_DANRE", "mass": 41882.0, "length": 374, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "gene_name": "lfng", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "lfng", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "", "tax_id": 7955, "disease": "spondylocostal dysostosis 3 (Disease Ontology:DOID:0112361)", "pathway": " (dre:30158)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11429294;11702199;14518000;15376327;16729214", "class_list": "", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain (PubMed:11429294, PubMed:14518000)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DEV1", "ec_number_list": "2.4.1.222", "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045665 negative regulation of neuron differentiation;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JHF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHF4-1", "uniprot_id": "PAL1A_DANRE", "mass": 76408.0, "length": 677, "protein_name": "Protein PALS1", "gene_name": "pals1a", "organism": "Zebrafish", "refseq_name": "protein PALS1", "refseq_ac": "NP_919344", "gene_names_uniprotkb": "pals1a; mpp5a; mpp5; nok", "gene_names_refseq": "mpp5a; mpp5; nok; pals1a; xwjm1", "protein_names_uniprotkb": "Protein PALS1; MAGUK family factor; MAGUK p55 subfamily member 5-A; Nagie oko protein; Protein associated with Lin-7 1", "protein_names_refseq": "MAGUK family factor; MAGUK p55 subfamily member 5-A; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5); membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a); nagie oko protein; protein PALS1; protein associated with LIN7 1, MAGUK family member a; protein associated with Lin-7 1", "tax_id": 7955, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:252845)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11992120;16319113;33060129;33361092", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF510111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF510111.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Coordinated assembly and release of adhesions builds apical junctional belts during de novo polarisation of an epithelial tube. Publication Status: Online-Only, [RefSeq, PubMed]; Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (PubMed:11992120, PubMed:16319113). Required for polarized epithelial organization, cell-cell adhesion and remodeling of myocardial cells during heart tube elongation during embryogenesis (PubMed:16319113). Functions in cellular patterning of the retina and development of the retinal pigmented epithelium (PubMed:11992120, PubMed:16319113). Also required for embryo body axis specification (PubMed:16319113)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060042 retina morphogenesis in camera-type eye;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0072659 protein localization to plasma membrane;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JHF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHI3-1", "uniprot_id": "AR13B_DANRE", "mass": 46566.0, "length": 407, "protein_name": "ADP-ribosylation factor-like protein 13B", "gene_name": "arl13b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "arl13b; arl2l1; chunp6872; fc23g07; wu:fc23g07; zgc:123149", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1; Protein scorpion", "protein_names_refseq": "", "tax_id": 7955, "disease": "Joubert syndrome 8 (Disease Ontology:DOID:0111003)", "pathway": " (dre:286784); (R-DRE-9013406); (R-DRE-9646399)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12006978;15269167;19906870", "class_list": "", "function": "Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex Required during embryogenesis for cilia formation in multiple organs such as the pronephric duct., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q561Z5", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005929 cilium;GO:0031514 motile cilium;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0035845 photoreceptor cell outer segment organization;GO:0007224 smoothened signaling pathway;GO:0021532 neural tube patterning;GO:0021830 interneuron migration from the subpallium to the cortex", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JHI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHV6-1", "uniprot_id": "LAMB4_DANRE", "mass": 203552.0, "length": 1827, "protein_name": "Laminin subunit beta-4", "gene_name": "lamb4", "organism": "Zebrafish", "refseq_name": "laminin subunit beta-4 precursor", "refseq_ac": "NP_775383", "gene_names_uniprotkb": "lamb4; fa05e06; wu:fa05e06", "gene_names_refseq": "fa05e06; lamb4; wu:fa05e06", "protein_names_uniprotkb": "Laminin subunit beta-4", "protein_names_refseq": "laminin subunit beta-4 precursor; laminin subunit beta-4", "tax_id": 7955, "disease": "", "pathway": " (dre:286831)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12070089;30924555", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01014225.1, SRR32588719.13180488.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Aug 2, 2023 this sequence version replaced NP_775383.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Positively regulates apical-basal distribution of Muller glia cells in the retina (PubMed:30924555)., [UniProtKB, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043256 laminin complex;GO:0005604 basement membrane", "go_biological_process": "GO:0021782 glial cell development;GO:0016477 cell migration;GO:0060041 retina development in camera-type eye;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JHV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JI10-1", "uniprot_id": "DMX1A_DANRE", "mass": 42716.0, "length": 388, "protein_name": "Diencephalon/mesencephalon homeobox protein 1-A", "gene_name": "dmbx1a", "organism": "Zebrafish", "refseq_name": "diencephalon/mesencephalon homeobox protein 1-A isoform 1", "refseq_ac": "NP_835457", "gene_names_uniprotkb": "dmbx1a; dmbx1; mbx1; mbx; pox1", "gene_names_refseq": "dmbx1a; dmbx1; etID309750.1; mbx; otx3; pox1; zMbx1", "protein_names_uniprotkb": "Diencephalon/mesencephalon homeobox protein 1-A; Paired homeobox protein 1", "protein_names_refseq": "diencephalon/mesencephalon homeobox protein 1-A isoform 1; diencephalon/mesencephalon homeobox protein 1-A; diencephalon/mesencephalon-expressed brain homeobox gene 1; homeoprotein Mbx; orthodenticle homolog 3; paired homeobox protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:142987)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12142024;16733737", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC134894.1, GFIL01008711.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505389 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On May 3, 2003 this sequence version replaced NP_835457.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for eye and tectum development. May act as a transcriptional repressor., [UniProtKB, PubMed]; Revealed a pattern of partial spatiotemporal expression divergence between the mbx paralogs that correlates with sequence divergence in noncoding regulatory domains, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JI09", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JI10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JIS6-1", "uniprot_id": "TBX6_DANRE", "mass": 94964.0, "length": 874, "protein_name": "T-box transcription factor TBX6", "gene_name": "tbx6", "organism": "Zebrafish", "refseq_name": "T-box transcription factor TBX6", "refseq_ac": "NP_705952", "gene_names_uniprotkb": "tbx6; tbx24", "gene_names_refseq": "ZF-TBX24; id:ibd5070; tbx24; tbx6r; tbx6; z.TBX24", "protein_names_uniprotkb": "T-box transcription factor TBX6; T-box protein 24; T-box protein 6; T-box transcription factor TBX24", "protein_names_refseq": "T-box 24; T-box 6; T-box protein 24; T-box protein 6; T-box transcription factor TBX24; T-box transcription factor TBX6; fss; fused somites", "tax_id": 7955, "disease": "scoliosis (Disease Ontology:DOID:0060249); spondylocostal dysostosis 5 (Disease Ontology:DOID:0112363)", "pathway": " (dre:192294)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12021786;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB036516.1, BC163297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476739, SAMEA4476740 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jun 16, 2015 this sequence version replaced NP_705952.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; T-box transcription factor involved in the development of paraxial mesoderm., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8JIR5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JIS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UUR3-1", "uniprot_id": "CYGB1_DANRE", "mass": 19909.0, "length": 174, "protein_name": "Cytoglobin-1", "gene_name": "cygb1", "organism": "Zebrafish", "refseq_name": "cytoglobin-1", "refseq_ac": "NP_694484", "gene_names_uniprotkb": "cygb1; cygb-1; cygb; zgc:109806", "gene_names_refseq": "cygb1; cygb; wu:fb77d07; wu:fb93a03; zgc:109806", "protein_names_uniprotkb": "Cytoglobin-1; 1.11.1.-; 1.14.12.-; 1.15.1.1; 1.7.-.-; Nitric oxygen dioxygenase CYGB; Nitrite reductase CYGB; Pseudoperoxidase CYGB; Superoxide dismutase CYGB", "protein_names_refseq": "cytoglobin-1; cyt; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; superoxide dismutase CYGB", "tax_id": 7955, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); chronic pancreatitis (Disease Ontology:DOID:0051065); liver cirrhosis (Disease Ontology:DOID:5082); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:246090)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11919282;16199220;37549740;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.1999321.1, SRR32588730.13563665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH436870.1 and JBMGRA010000003.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier., [UniProtKB, UniProtKB]; The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q504J2", "ec_number_list": "1.8.-.-;1.15.1.1;1.11.1.-;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004784 superoxide dismutase activity;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046686 response to cadmium ion;GO:0014032 neural crest cell development;GO:0019430 removal of superoxide radicals;GO:0046210 nitric oxide catabolic process;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8UUR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UUZ1-1", "uniprot_id": "MB212_DANRE", "mass": 41014.0, "length": 359, "protein_name": "Protein mab-21-like 2", "gene_name": "mab21l2", "organism": "Zebrafish", "refseq_name": "protein mab-21-like 2", "refseq_ac": "NP_694507", "gene_names_uniprotkb": "mab21l2", "gene_names_refseq": "id:ibd3414; mab21l2", "protein_names_uniprotkb": "Protein mab-21-like 2", "protein_names_refseq": "protein mab-21-like 2; unm_au10", "tax_id": 7955, "disease": "syndromic microphthalmia 14 (Disease Ontology:DOID:0111802); microphthalmia (Disease Ontology:DOID:10629); coloboma (Disease Ontology:DOID:12270)", "pathway": " (dre:117234)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11677058;11960703;15183718;16934393;25719200;36576422;39455595", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC065628.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065628.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development., [RefSeq, PubMed]; Mab21 genes play a role in differentiation of the early differentiating olfactory bulbs, eye primordia, midbrain and subsequently the branchial pouches and neural tube, [RefSeq, PubMed]; Mab21l2 is an early downstream effector of rx3 and is critical for survival of eye progenitors., [RefSeq, PubMed]; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0061386 closure of optic fissure;GO:0060041 retina development in camera-type eye;GO:0002072 optic cup morphogenesis involved in camera-type eye development;GO:0031076 embryonic camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8UUZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UVJ6-1", "uniprot_id": "VANG2_DANRE", "mass": 60082.0, "length": 526, "protein_name": "Vang-like protein 2", "gene_name": "vangl2", "organism": "Zebrafish", "refseq_name": "vang-like protein 2", "refseq_ac": "NP_705960", "gene_names_uniprotkb": "vangl2; stbm; tri; vang", "gene_names_refseq": "stbm; tri; vangl2; vang", "protein_names_uniprotkb": "Vang-like protein 2; Protein strabismus; Protein trilobite; Van Gogh-like protein 2", "protein_names_refseq": "protein strabismus; protein trilobite; strabismus; trilobite; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila); vang-like protein 2", "tax_id": 7955, "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (dre:245949); (R-DRE-9696264); (R-DRE-9696270); (R-DRE-9696273)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10992326;10996075;11780127;11820812;12105418;12874125;15829519;16407953;17239849;9007230;9007234;9007236;9808788", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF428249.1, SRR32588724.558860.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural progenitor cell morphogenesis, segregation of somites and adaxial cell development. Together with prickle1, required for the posterior (caudal) movement of branchiomotor neurons in the hindbrain independently of, and a few hours after, convergent extension (PubMed:10992326, PubMed:10996075, PubMed:11780127, PubMed:11820812, PubMed:12105418, PubMed:12874125, PubMed:15829519, PubMed:16407953, PubMed:17239849, PubMed:9007230, PubMed:9007234, PubMed:9007236, PubMed:9808788, Ref.2). May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZS8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0060972 left/right pattern formation;GO:0048570 notochord morphogenesis;GO:0097475 motor neuron migration;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8UVJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UVK2-1", "uniprot_id": "SPT6H_DANRE", "mass": 198167.0, "length": 1726, "protein_name": "Transcription elongation factor SPT6", "gene_name": "supt6h", "organism": "Zebrafish", "refseq_name": "transcription elongation factor SPT6", "refseq_ac": "NP_660094", "gene_names_uniprotkb": "supt6h; pan; spt6", "gene_names_refseq": "Spt6; supt6h; wu:fj42h11", "protein_names_uniprotkb": "Transcription elongation factor SPT6; Protein pandora", "protein_names_refseq": "protein pandora; suppressor of Ty 6 homolog; transcription elongation factor SPT6", "tax_id": 7955, "disease": "", "pathway": " (dre:337866); (R-DRE-674695); (R-DRE-75955)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11923199;17570355;18307296;23503590;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF421378.1, BC063248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF421378.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Plays an important role during early patterning and somitogenesis of the embryo., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V961;Q6P4U2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0007507 heart development;GO:0001756 somitogenesis;GO:0071599 otic vesicle development;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8UVK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UVX0-1", "uniprot_id": "PIWL1_DANRE", "mass": 97451.0, "length": 858, "protein_name": "Piwi-like protein 1", "gene_name": "piwil1", "organism": "Zebrafish", "refseq_name": "piwi-like protein 1", "refseq_ac": "NP_899181", "gene_names_uniprotkb": "piwil1; ziwi", "gene_names_refseq": "piwil1; ziwi", "protein_names_uniprotkb": "Piwi-like protein 1; 3.1.26.-", "protein_names_refseq": "piwi-like 1; piwi-like protein 1", "tax_id": 7955, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "14516689;17418787;18833190", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.9359.1, SRR32588719.14419303.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:14516689, PubMed:17418787, PubMed:18833190). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:14516689, PubMed:17418787, PubMed:18833190). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:14516689, PubMed:17418787, PubMed:18833190). Has a strong preference for piRNAs with a uridine nucleotide at their 5'-end (g1U preference, also named 1U-bias) and binds piRNAs in an opposite direction compared to piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190). Participates in a piRNA amplification loop with piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWB5", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007281 germ cell development;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8UVX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UWJ4-1", "uniprot_id": "DLLD_DANRE", "mass": 79061.0, "length": 717, "protein_name": "Delta-like protein D", "gene_name": "dld", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dld; aei; dldh; sc:d0402", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta-like protein D; After eight protein; DeltaD", "protein_names_refseq": "", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:30138)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10101116;10191075;11100729;12361969;12530964;15013799;15068793;35900444;36047082;36253375;37214246;38205258;9007237;9203139;9425132;9706695;9765210", "class_list": "", "function": "Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized., [UniProtKB, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P87357", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0046331 lateral inhibition;GO:0007219 Notch signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8UWJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90259-1", "uniprot_id": "ASL1A_DANRE", "mass": 21928.0, "length": 196, "protein_name": "Achaete-scute homolog 1a", "gene_name": "ascl1a", "organism": "Zebrafish", "refseq_name": "achaete-scute homolog 1a", "refseq_ac": "NP_571294", "gene_names_uniprotkb": "ascl1a; ash1a; asha; ash; pia", "gene_names_refseq": "Zash-1a; ascl1a; asha; ash; id:ibd5085; im:7138587; si:dkey-264k15.2; zash1a; zasha", "protein_names_uniprotkb": "Achaete-scute homolog 1a; Pituitary-absent protein; Zash-1a", "protein_names_refseq": "achaete-scute homolog 1a; pia; pituitary absent; pituitary-absent protein", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dre:30466)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12702659;15659486;16481349;23594743;7813774", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U14587.1, BC098521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U14587.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0031099 regeneration;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90271-1", "uniprot_id": "RARAA_DANRE", "mass": 49924.0, "length": 444, "protein_name": "Retinoic acid receptor alpha-A", "gene_name": "raraa", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor alpha-A", "refseq_ac": "NP_571481", "gene_names_uniprotkb": "raraa; nr1b1a; rara2a; zgc:109797", "gene_names_refseq": "etID309833.12; rara2a; raraa; rara; zRAR-alpha; zRAR; zgc:109797", "protein_names_uniprotkb": "Retinoic acid receptor alpha-A; Nuclear receptor subfamily 1 group B member 1-A; RAR-alpha-2.A; RAR-alpha-A; Retinoic acid receptor alpha-2.A; Retinoic acid receptor alpha; zRAR alpha", "protein_names_refseq": "NR1B1-A; RAR-alpha-2.A; RAR-alpha-A; RARalpha-A; nr1b1a; nuclear receptor subfamily 1 group B member 1-A; retinoic acid receptor alpha a 201; retinoic acid receptor alpha-2.A; retinoic acid receptor alpha-A; retinoic acid receptor, alpha 2a; zRAR alpha; zRAR-alpha-2.A", "tax_id": 7955, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); syndromic microphthalmia 12 (Disease Ontology:DOID:0111800); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (dre:30680); (R-DRE-383280); (R-DRE-4090294); (R-DRE-5362517); (R-DRE-9616222)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "16455309;18929555;7918098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092692.1, S74155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092692.1. On May 1, 2005 this sequence version replaced NP_571481.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91391", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90413-1", "uniprot_id": "FGFR4_DANRE", "mass": 103465.0, "length": 922, "protein_name": "Fibroblast growth factor receptor 4", "gene_name": "fgfr4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "fgfr4; etID309818.21; wu:fc13h10; zgc:111935", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor 4; 2.7.10.1; FGFR-4", "protein_names_refseq": "", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); bone disease (Disease Ontology:DOID:0080001); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:100000160); (R-DRE-109704); (R-DRE-1257604); (R-DRE-1307965); (R-DRE-190322); (R-DRE-5654228); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5654720); (R-DRE-5654733); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "8589434", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137;3.1.3.48", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0008284 positive regulation of cell population proliferation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90417-1", "uniprot_id": "RXRBB_DANRE", "mass": 46732.0, "length": 422, "protein_name": "Retinoic acid receptor RXR-beta-B", "gene_name": "rxrbb", "organism": "Zebrafish", "refseq_name": "retinoic acid receptor RXR-beta-B", "refseq_ac": "NP_571313", "gene_names_uniprotkb": "rxrbb; RXR; nr2b2b; rxrd; unp286", "gene_names_refseq": "RXR; rxrbb; rxrd; unp286", "protein_names_uniprotkb": "Retinoic acid receptor RXR-beta-B; Nuclear receptor subfamily 2 group B member 2-B; Retinoic acid receptor RXR-delta; Retinoid X receptor beta-B; Retinoid X receptor delta", "protein_names_refseq": "NR2B2-B; nuclear receptor subfamily 2 group B member 2-B; retinoic acid receptor RXR-beta-B; retinoic acid receptor RXR-delta; retinoid X receptor beta-B; retinoid X receptor delta; retinoid receptor-delta; retinoid x receptor, delta", "tax_id": 7955, "disease": "", "pathway": " (dre:30486)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16448862;7565671", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U29941.1, BC162301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U29941.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90419-1", "uniprot_id": "TWHH_DANRE", "mass": 46576.0, "length": 416, "protein_name": "Tiggy-winkle hedgehog protein", "gene_name": "shhb", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "shhb; twhh", "gene_names_refseq": "", "protein_names_uniprotkb": "Tiggy-winkle hedgehog protein; 3.1.-.-; SHHB; Shh N-terminal processed signaling domains; ShhNp; ShhN; Sonic hedgehog protein B; Sonic hedgehog protein N-product; TWHH", "protein_names_refseq": "", "tax_id": 7955, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly II (Disease Ontology:DOID:0060986); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Parkinsonism (Disease Ontology:DOID:0080855); holoprosencephaly 3 (Disease Ontology:DOID:0110875); solitary median maxillary central incisor (Disease Ontology:DOID:0111380); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); membranous glomerulonephritis (Disease Ontology:DOID:10976); polydactyly (Disease Ontology:DOID:1148); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); biliary atresia (Disease Ontology:DOID:13608); hypothyroidism (Disease Ontology:DOID:1459); VACTERL association (Disease Ontology:DOID:14679); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); holoprosencephaly (Disease Ontology:DOID:4621); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (R-DRE-5358346); (R-DRE-5362798); (R-DRE-5632681)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12588855;16452095;7583153;8917540", "class_list": "", "function": "The dually lipidated tiggy-winkle hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development (By similarity). Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes (PubMed:7583153). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Together with shha shares a redundant function in posterior specification of the anterior otic regions of the ear during development (PubMed:12588855). In conjunction with shha, required for correct pre-thalamic development and to a lesser extent thalamic development during embryogenesis, via downstream regulation of differentiation factors dlx2a and ptch1 (PubMed:16452095). The C-terminal part of the tiggy-winkle hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Once cleaved, the C-product is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O13212", "ec_number_list": "5.3.4.1;3.1.1.98;3.6.4.6;2.3.2.27;3.1.-.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0007267 cell-cell signaling;GO:0030900 forebrain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90473-1", "uniprot_id": "HSP7C_DANRE", "mass": 70974.0, "length": 649, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "hspa8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hspa8; hsc70", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8", "protein_names_refseq": "", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); graft-versus-host disease (Disease Ontology:DOID:0081267); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-DRE-3371453); (R-DRE-3371497); (R-DRE-3371568); (R-DRE-3371571); (R-DRE-450408); (R-DRE-6798695); (R-DRE-72163); (R-DRE-8876725); (R-DRE-9833482)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "9204550", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (By similarity). May play a role in uncoating of clathrin-coated vesicles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0031076 embryonic camera-type eye development;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90474-1", "uniprot_id": "H90A1_DANRE", "mass": 83319.0, "length": 725, "protein_name": "Heat shock protein HSP 90-alpha 1", "gene_name": "hsp90a.1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hsp90a.1; hsp90aa1; hsp90a; hsp90; zgc:86652", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein HSP 90-alpha 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:30591)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10364427;10707908;17586488;18182494;18256191;18347070;23594743;40044042;7980538;8652412", "class_list": "", "function": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (By similarity). Plays a key role in slow and fast muscle development in the embryo. Plays a role in myosin expression and assembly (PubMed:10364427, PubMed:17586488, PubMed:18182494, PubMed:18256191)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RG13;Q6DI33", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0030235 nitric-oxide synthase regulator activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043209 myelin sheath", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0071688 striated muscle myosin thick filament assembly;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0034605 cellular response to heat;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q90474-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90476-1", "uniprot_id": "LHX1_DANRE", "mass": 45154.0, "length": 405, "protein_name": "LIM/homeobox protein Lhx1", "gene_name": "lhx1a", "organism": "Zebrafish", "refseq_name": "LIM/homeobox protein Lhx1", "refseq_ac": "NP_571291", "gene_names_uniprotkb": "lhx1a; LHX1; lhx1; lim1; wu:fe25d04; wu:fj36b06", "gene_names_refseq": "LHX1; lhx1a; lim1; wu:fe25d04; wu:fj36b06", "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1; LIM homeobox protein 1", "protein_names_refseq": "LIM homeobox protein 1; LIM/homeobox protein Lhx1; homeobox protein Lim-1; lim1a", "tax_id": 7955, "disease": "", "pathway": " (dre:30463)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7768180", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L37802.1, BC162396.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505378 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L37802.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Seems to play a role in dorsal axis formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060429 epithelium development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90476-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90477-1", "uniprot_id": "MYOD1_DANRE", "mass": 30936.0, "length": 275, "protein_name": "Myoblast determination protein 1 homolog", "gene_name": "myod1", "organism": "Zebrafish", "refseq_name": "myoblast determination protein 1 homolog", "refseq_ac": "NP_571337", "gene_names_uniprotkb": "myod1; myod", "gene_names_refseq": "etID309723.25; myod1; myod; wu:fb57a01; zgc:136744", "protein_names_uniprotkb": "Myoblast determination protein 1 homolog; Myogenic factor 1", "protein_names_refseq": "myoblast determination 1; myoblast determination protein 1 homolog; myogenic factor 1", "tax_id": 7955, "disease": "congenital myopathy 17 (Disease Ontology:DOID:0081349); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30513)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12524040;8565839", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC114261.1, Z36945.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114261.1. On Aug 23, 2006 this sequence version replaced NP_571337.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RD1;Q98TY7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90485-1", "uniprot_id": "HBB2_DANRE", "mass": 16389.0, "length": 148, "protein_name": "Hemoglobin subunit beta-2", "gene_name": "ba2l; ba2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ba2l; ba2; si:dz118j2.1; si:dz118j2.3; zgc:92900", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemoglobin subunit beta-2; Beta-2-globin; Beta-A2-globin; Hemoglobin beta-2 chain", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "23594743;40044042;9002973", "class_list": "", "function": "Involved in oxygen transport from gills to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7SZW0;Q7T3C2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0030097 hemopoiesis;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90485-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90486-1", "uniprot_id": "HBB1_DANRE", "mass": 16389.0, "length": 148, "protein_name": "Hemoglobin subunit beta-1", "gene_name": "ba1l; ba1", "organism": "Zebrafish", "refseq_name": "ba1 globin, like", "refseq_ac": "NP_001013045", "gene_names_uniprotkb": "ba1l; ba1; si:by187g17.2; si:by187g17.4; zgc:123164", "gene_names_refseq": "ba1l; ba2l; ba2; hbba1.1; si:bY187G17.4; si:dZ118J2.1; si:dz118j2.3; zgc:92900", "protein_names_uniprotkb": "Hemoglobin subunit beta-1; Beta-1-globin; Beta-A1-globin; Hemoglobin beta-1 chain", "protein_names_refseq": "Beta-2-globin; Beta-A2-globin; HbB; Hemoglobin beta-2 chain; Hemoglobin subunit beta-2; ba1 globin, like", "tax_id": 7955, "disease": "sickle cell anemia (Disease Ontology:DOID:10923)", "pathway": " (dre:30216); (dre:504174); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23594743;40044042;9002973", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EB973053.1, EH448876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL929176.4., [RefSeq]; Involved in oxygen transport from gills to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P4G3;Q3B7Q0;Q90488", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0001666 response to hypoxia;GO:0030097 hemopoiesis;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90X44-2", "uniprot_id": "NRF1_DANRE", "mass": 54708.0, "length": 514, "protein_name": "Nuclear respiratory factor 1", "gene_name": "nrf1", "organism": "Zebrafish", "refseq_name": "nuclear respiratory factor 1 isoform 1", "refseq_ac": "NP_001315469", "gene_names_uniprotkb": "nrf1", "gene_names_refseq": "SC:BZ3C13.1; SC:bZ3C13.2; nrf1; ube2h", "protein_names_uniprotkb": "Nuclear respiratory factor 1; Not really finished protein; Nrf-1", "protein_names_refseq": "not really finished protein; nrf-1; nrl; nuclear respiratory factor 1 isoform 1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:64604)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;9778497", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044537.1, SRR26395028.84396.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jun 17, 2016 this sequence version replaced XP_005164766.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable transcription factor that is required for normal development of the outer retina., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93570;Q7ZTS6", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070417 cellular response to cold;GO:0003407 neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90X44-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90X46-1", "uniprot_id": "G161B_DANRE", "mass": 58485.0, "length": 526, "protein_name": "G protein-coupled receptor 161B", "gene_name": "gpr161b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gpr161b; si:rp71-20i5.4", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-coupled receptor 161B", "protein_names_refseq": "", "tax_id": 7955, "disease": "medulloblastoma (Disease Ontology:DOID:0050902)", "pathway": " (dre:368421); (R-DRE-5632684)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18755178;23594743;31884103;33531430", "class_list": "", "function": "G protein-coupled receptor that acts as a key inhibitor of the smoothened signaling pathway in primary cilia (PubMed:33531430). Inhibits the smoothened signaling pathway in absence of hedgehog (DHH, IHH or SHH) by promoting formation of the transcription repressor form of GLI2 and GLI3 transcription factors (By similarity). GPR161 activation triggers signaling via guanine nucleotide-binding protein G(s)/GNAS, mediating activation of adenylate cyclase activity and production of cAMP (PubMed:33531430). Increased cAMP levels activate PKA, promoting PKA-dependent processing of GLI2 and GLI3 transcription factors, leading to formation of transcription repressor GLI2R and GLI3R, which repress expression of target genes (PubMed:33531430). In presence of hedgehog, GPR161 is removed from primary cilia by smoothened (SMO), preventing its activity and allowing activation of the smoothened signaling (By similarity). In contrast to the majority of G protein-coupled receptors, it is not activated by a ligand and it either acts as a constitutively active receptor or as a mechanosensitive receptor (By similarity). Required in left/right patterning in the cells surrounding the Kupffer vesicle (PubMed:18755178)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A4IGB3", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005929 cilium;GO:0055037 recycling endosome;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051924 regulation of calcium ion transport;GO:0007368 determination of left/right symmetry;GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90X46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90XC2-1", "uniprot_id": "NEK8_DANRE", "mass": 76541.0, "length": 697, "protein_name": "Serine/threonine-protein kinase Nek8", "gene_name": "nek8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "nek8", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek8; 2.7.11.1; Never in mitosis A-related kinase 8; NimA-related protein kinase 8", "protein_names_refseq": "", "tax_id": 7955, "disease": "renal-hepatic-pancreatic dysplasia (Disease Ontology:DOID:0060259); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); nephronophthisis 9 (Disease Ontology:DOID:0111120)", "pathway": " (dre:171094)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12421721;23793029;26967905", "class_list": "", "function": "Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0061326 renal tubule development;GO:0007507 heart development;GO:0051301 cell division;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90XC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90XE6-1", "uniprot_id": "KLF1_DANRE", "mass": 41687.0, "length": 365, "protein_name": "Kruppel-like factor 1", "gene_name": "klf1", "organism": "Zebrafish", "refseq_name": "Kruppel-like factor 1", "refseq_ac": "NP_571011", "gene_names_uniprotkb": "klf1; eklf; klfd", "gene_names_refseq": "klf1; klfd; zgc:194069", "protein_names_uniprotkb": "Kruppel-like factor 1; Erythroid krueppel-like transcription factor; Kruppel-like factor d", "protein_names_refseq": "Krueppel-like factor 1; Kruppel-like factor 1; Kruppel-like factor d; erythroid krueppel-like transcription factor", "tax_id": 7955, "disease": "congenital dyserythropoietic anemia type IVb (Disease Ontology:DOID:0051002); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); congenital dyserythropoietic anemia type IVa (Disease Ontology:DOID:0111400); beta thalassemia (Disease Ontology:DOID:12241); hereditary spherocytosis (Disease Ontology:DOID:12971); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:30104)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11535513;18941117;23594743;33833125", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF392996.1, BC162384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF392996.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription regulator (PubMed:18941117, PubMed:33833125). Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1.1 and microRNA mir-144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144 (PubMed:18941117, PubMed:33833125). May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes (PubMed:33833125). Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts (PubMed:33833125)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0010725 regulation of primitive erythrocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90XE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90XF2-1", "uniprot_id": "KPCI_DANRE", "mass": 67322.0, "length": 588, "protein_name": "Protein kinase C iota type", "gene_name": "prkci", "organism": "Zebrafish", "refseq_name": "protein kinase C iota type", "refseq_ac": "NP_571930", "gene_names_uniprotkb": "prkci; hal", "gene_names_refseq": "aPKC[l]; hal; has; prkci", "protein_names_uniprotkb": "Protein kinase C iota type; 2.7.11.13; Atypical protein kinase C-lambda/iota; Heart and soul protein; aPKC-lambda/iota; nPKC-iota", "protein_names_refseq": "aPKC-lambda/iota; atypical protein kinase C-lambda/iota; heart and soul protein; nPKC-iota; protein kinase C iota type", "tax_id": 7955, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); ovarian carcinoma (Disease Ontology:DOID:4001); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:117507); (R-DRE-1912408); (R-DRE-209543); (R-DRE-420029); (R-DRE-9755511)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11591316;16319113", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF390109.1, BC047164.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505379 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC075736.1, EB966090.1, EB880353.1 and BX511231.4. On Mar 20, 2007 this sequence version replaced NP_571930.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division (PubMed:11591316). Required for polarized epithelial organization, myocardium coherence and cell connectivity in the early somite stages (PubMed:16319113). Required for heart cone tilt and development of circulatory architecture during embryogenesis (PubMed:16319113)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU17", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;2.3.2.27", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005915 zonula adherens", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0007507 heart development;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90XF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90YL6-1", "uniprot_id": "NR5A2_DANRE", "mass": 58761.0, "length": 517, "protein_name": "Nuclear receptor subfamily 5 group A member 2", "gene_name": "nr5a2", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 5 group A member 2", "refseq_ac": "NP_001300658", "gene_names_uniprotkb": "nr5a2; LRH1; ff1a; ftzf1; ftz; sf1; zFF1A; zFF1B; zFF1", "gene_names_refseq": "LRH-1; LRH1; ff1a; ftzf1; ftz; nr5a2; sf1; zFF1A; zFF1B; zFF1", "protein_names_uniprotkb": "Nuclear receptor subfamily 5 group A member 2; FTZ-F1 homolog; LRH-1; Liver receptor homolog 1; zFF1", "protein_names_refseq": "FTZ-F1 homolog; fushi tarazu; liver receptor homolog 1; nuclear receptor subfamily 5 group A member 2; steroidogenic factor 1", "tax_id": 7955, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (dre:30749); (R-DRE-383280); (R-DRE-4090294)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10747875;14517294;15725073;18950725;23594743;27474396;28642062;36905926;9178748", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01028565.1, BC163522.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Aug 27, 2015 this sequence version replaced XP_009294500.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Lacks transcription factor activity; unable to activate expression of target genes., [UniProtKB, PubMed]; Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as cholesterol and bile acid synthesis pathways, as well as cartilage, liver and pancreas morphogenesis (PubMed:10747875, PubMed:14517294, PubMed:18950725, PubMed:27474396, PubMed:36905926). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (By similarity). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (By similarity). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (By similarity). Involved in the formation of connective tissue in lower jaw (PubMed:36905926)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The cloning and expression of 4 homologous genes in D. rerio are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IW70;A0A8M3AXL9;A0A8N7XJG3;B3DJL1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005694 chromosome;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0061017 hepatoblast differentiation;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q90YL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Z00-1", "uniprot_id": "FGR1A_DANRE", "mass": 91041.0, "length": 810, "protein_name": "Fibroblast growth factor receptor 1-A", "gene_name": "fgfr1a", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor receptor 1-A isoform 2 precursor", "refseq_ac": "NP_001296328", "gene_names_uniprotkb": "fgfr1a; fgfr1; si:ch211-198o12.1", "gene_names_refseq": "FGFR-1-A; bFGF-R-1-A; cb231; fgfr1a; fgfr1; sb:cb231", "protein_names_uniprotkb": "Fibroblast growth factor receptor 1-A; 2.7.10.1; Basic fibroblast growth factor receptor 1-A; FGFR-1-A; bFGF-R-1-A", "protein_names_refseq": "Fgf receptor 1a isoform IIIb; Fgf receptor 1a isoform IIIc; basic fibroblast growth factor receptor 1-A; fibroblast growth factor receptor 1-A isoform 2 precursor", "tax_id": 7955, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atypical chronic myeloid leukemia, BCR-ABL1 negative (Disease Ontology:DOID:0060597); myeloid neoplasm (Disease Ontology:DOID:0070004); bone disease (Disease Ontology:DOID:0080001); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 2 with or without anosmia (Disease Ontology:DOID:0090083); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); osteoglophonic dysplasia (Disease Ontology:DOID:0111532); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); acrocephalosyndactylia (Disease Ontology:DOID:12960); Pfeiffer syndrome (Disease Ontology:DOID:14705); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mouth disease (Disease Ontology:DOID:403); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); fibrolamellar carcinoma (Disease Ontology:DOID:5015); retinal detachment (Disease Ontology:DOID:5327); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30705); (R-DRE-109704); (R-DRE-1257604); (R-DRE-190370); (R-DRE-190373); (R-DRE-190374); (R-DRE-5654219); (R-DRE-5654687); (R-DRE-5654688); (R-DRE-5654689); (R-DRE-5654693); (R-DRE-5654726); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 14, "publication_count": 4, "publication_id_list": "15221377;16488878;18296487;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.18506088.1, SRR32588728.46191910.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH588801.1 and JBMGRA010000008.1. On May 29, 2015 this sequence version replaced XP_009302581.1. Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity)., [UniProtKB]; We describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1)., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2BEU6;A2BEU7;A4JYD6;B3DGB8;Q1LY25;Q800Y8;Q800Y9;Q800Z0;Q800Z1", "ec_number_list": "2.7.10.1;2.7.10.2;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137;3.1.3.48", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045471 response to ethanol;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90Z00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Z37-1", "uniprot_id": "CADH1_DANRE", "mass": 95255.0, "length": 864, "protein_name": "Cadherin-1", "gene_name": "cdh1", "organism": "Zebrafish", "refseq_name": "cadherin-1 precursor", "refseq_ac": "NP_571895", "gene_names_uniprotkb": "cdh1; E-cadherin; E-cad", "gene_names_refseq": "E-cadherin; cdh1", "protein_names_uniprotkb": "Cadherin-1; E-cadherin", "protein_names_refseq": "cadherin 1, epithelial; cadherin-1 precursor; cadherin-1; hab; half baked", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); blepharocheilodontic syndrome 1 (Disease Ontology:DOID:0080345); hereditary diffuse gastric cancer (Disease Ontology:DOID:0080764); congenital hypotrichosis with juvenile macular dystrophy (Disease Ontology:DOID:0110711); ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (Disease Ontology:DOID:0111649); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); invasive lobular carcinoma (Disease Ontology:DOID:3457); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:114424); (R-DRE-1474228); (R-DRE-351906); (R-DRE-418990); (R-DRE-5626467); (R-DRE-9764561); (R-DRE-9766229); (R-DRE-9768727); (R-DRE-9958810); (R-DRE-9958825)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10456847;11376490;12972001;14648850;15162505;19101534;23594743;27760340;28842668;29376824;29980668;30361324;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF364811.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF364811.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system, [RefSeq, PubMed]; Cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish, [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins (By similarity). Required for normal cleavage symmetry and compaction of blastomeres in cleavage stage embryos, maintains convergence and extension cell movements during epiboly and gastrulation and promotes prechordal plate survival, potentially as a result of its role in cell-cell junctional complexes (PubMed:15162505). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 1, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0001965 G-protein alpha-subunit binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0001764 neuron migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q90Z37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZE2-1", "uniprot_id": "ZN703_DANRE", "mass": 61572.0, "length": 589, "protein_name": "Zinc finger protein 703", "gene_name": "znf703", "organism": "Zebrafish", "refseq_name": "zinc finger protein 703", "refseq_ac": "NP_571897", "gene_names_uniprotkb": "znf703; nlz1; nlz; noz1; si:dkey-158j20.1", "gene_names_refseq": "NH11; cb514; fc45d06; fk28e09; nlz1; nlz; noz1; wu:fc45d06; wu:fk28e09; zgc:111927; znf703", "protein_names_uniprotkb": "Zinc finger protein 703; NocA-like zinc finger protein 1; NocA-related zinc finger protein 1", "protein_names_refseq": "nocA related zinc finger 1; nocA-like zinc finger protein 1; nocA-related zinc finger protein 1; zinc finger protein 703", "tax_id": 7955, "disease": "", "pathway": " (dre:114429)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11307172;11404087;14550789;14709556;15042707;19014486;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF222996.1, AY026937.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476786, SAMEA4476813 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF222996.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon., [RefSeq, PubMed]; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90YM7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0030335 positive regulation of cell migration;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90ZE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZE4-1", "uniprot_id": "PSN2_DANRE", "mass": 49169.0, "length": 441, "protein_name": "Presenilin-2", "gene_name": "psen2", "organism": "Zebrafish", "refseq_name": "presenilin-2", "refseq_ac": "NP_571589", "gene_names_uniprotkb": "psen2; pre2; zf-PS2", "gene_names_refseq": "pre2; psen2; zf-PS2", "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; PS-2; Pre2; Zf-PS2", "protein_names_refseq": "PS-2; presenilin-2", "tax_id": 7955, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 4 (Disease Ontology:DOID:0110040); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1V (Disease Ontology:DOID:0110427); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:58026); (R-DRE-1251985); (R-DRE-193692); (R-DRE-3928665); (R-DRE-9839383)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12424519;19563801;36766721", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF178539.1, BC065382.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF178539.1. On Dec 20, 2003 this sequence version replaced NP_571589.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (By similarity). May play a more prominent role in Notch signaling (PubMed:19563801)., [UniProtKB, PubMed, UniProtKB]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB]; Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I991", "ec_number_list": "2.7.10.1;3.4.23.-", "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:1904115 axon cytoplasm;GO:0070765 gamma-secretase complex", "go_biological_process": "GO:0001964 startle response;GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90ZE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91392-1", "uniprot_id": "RARGA_DANRE", "mass": 56195.0, "length": 499, "protein_name": "Retinoic acid receptor gamma-A", "gene_name": "rarga", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rarga; NR1B3; etID309710.23; etID33387.23; nr1b3a; rarg2; rarg; si:dkey-148f24.2; wu:fb01e02; wu:fb01f03; wu:fc35a09", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor gamma-A; Nuclear receptor subfamily 1 group B member 3-A; RAR-gamma-2; RAR-gamma-A; zRAR gamma", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:30606); (R-DRE-383280); (R-DRE-5362517)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16455309;17195188;18929555;23594743;7565671;7918098;9192646", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BGD3;O42552;Q4KMK9;Q90273", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91392-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92008-1", "uniprot_id": "SHH_DANRE", "mass": 46403.0, "length": 418, "protein_name": "Sonic hedgehog protein", "gene_name": "shha", "organism": "Zebrafish", "refseq_name": "sonic hedgehog protein precursor", "refseq_ac": "NP_571138", "gene_names_uniprotkb": "shha; ShhNC; fc83d08; shh; syu; vhh-1; vhh1; wu:fc83d08", "gene_names_refseq": "ShhNC; fc83d08; shha; shh; syu; vhh-1; vhh1; wu:fc83d08", "protein_names_uniprotkb": "Sonic hedgehog protein; 3.1.-.-; SHHA; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; ShhNp; ShhN; Sonic hedgehog protein N-product; VHH-1", "protein_names_refseq": "shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; sonic hedgehog a; sonic hedgehog protein A; sonic hedgehog protein precursor; sonic-you", "tax_id": 7955, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly II (Disease Ontology:DOID:0060986); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Parkinsonism (Disease Ontology:DOID:0080855); holoprosencephaly 3 (Disease Ontology:DOID:0110875); solitary median maxillary central incisor (Disease Ontology:DOID:0111380); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); membranous glomerulonephritis (Disease Ontology:DOID:10976); polydactyly (Disease Ontology:DOID:1148); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); biliary atresia (Disease Ontology:DOID:13608); hypothyroidism (Disease Ontology:DOID:1459); VACTERL association (Disease Ontology:DOID:14679); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); holoprosencephaly (Disease Ontology:DOID:4621); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (dre:30269); (R-DRE-5358346); (R-DRE-5362798); (R-DRE-5632681)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10207136;12588855;16452095;7579523;7583153;8124714;8917540", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L27585.1, GDQH01028172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L27585.1, JBMGRA010000007.1 and CT668143.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development (By similarity). Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes (PubMed:7583153). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Together with shhb/twhh shares a redundant function in posterior specification of the anterior otic regions of the ear during development (PubMed:12588855). In conjunction with shhb/twhh, required for correct pre-thalamic development and thalamic development during embryogenesis, via downstream regulation of differentiation factors dbx1a, dlx2a and ptch1 (PubMed:16452095). The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O13170;O13171;O13208;O13209;O13245;O13246", "ec_number_list": "5.3.4.1;3.1.1.98;3.6.4.6;2.3.2.27;3.1.-.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0021984 adenohypophysis development;GO:0021508 floor plate formation;GO:0021520 spinal cord motor neuron cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q92008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98862-1", "uniprot_id": "IHH_DANRE", "mass": 45746.0, "length": 412, "protein_name": "Indian hedgehog B protein", "gene_name": "ihhb", "organism": "Zebrafish", "refseq_name": "indian hedgehog B protein precursor", "refseq_ac": "NP_571163", "gene_names_uniprotkb": "ihhb; IHH; ehh; ihh; zgc:113262", "gene_names_refseq": "IHH; ehh; ihhb; zgc:113262", "protein_names_uniprotkb": "Indian hedgehog B protein; 3.1.-.-; EHH; Echidna hedgehog protein; IHHB", "protein_names_refseq": "Indian hedgehog homolog b; echidna hedgehog protein; hh[b]; hhb; indian hedgehog B protein precursor; indian hedgehog B protein", "tax_id": 7955, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); familial adenomatous polyposis (Disease Ontology:DOID:0050424); acrocapitofemoral dysplasia (Disease Ontology:DOID:0050604); autism spectrum disorder (Disease Ontology:DOID:0060041); annular pancreas (Disease Ontology:DOID:0060850); brachydactyly type A1 (Disease Ontology:DOID:0110964); syndactyly type 1 (Disease Ontology:DOID:0111816); Hirschsprung's disease (Disease Ontology:DOID:10487); retinopathy of prematurity (Disease Ontology:DOID:13025); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dre:30299)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12588855;8684485;8917540", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y08426.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476749, SAMEA4476811 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y08426.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (By similarity). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, N-product acts as a morphogen, while C-product is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (By similarity). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (By similarity). In the absence of IHH, patched represses the constitutive signaling activity of SMO (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (By similarity). In the notochord, induces somite patterning and muscle pioneer differentiation (PubMed:8684485)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0034189 very-low-density lipoprotein particle binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0007267 cell-cell signaling;GO:0010468 regulation of gene expression;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q98862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98878-1", "uniprot_id": "DLX4B_DANRE", "mass": 28183.0, "length": 254, "protein_name": "Homeobox protein Dlx4b", "gene_name": "dlx4b", "organism": "Zebrafish", "refseq_name": "homeobox protein Dlx4b", "refseq_ac": "NP_571393", "gene_names_uniprotkb": "dlx4b; dlx7; zgc:109858", "gene_names_refseq": "dlx4b; dlx7; fj03c01; wu:fj03c01; zgc:109858", "protein_names_uniprotkb": "Homeobox protein Dlx4b; DLX-7; Distal-less homeobox protein 4b", "protein_names_refseq": "DLX-7; distal-less homeobox gene 4b; distal-less homeobox gene 7; distal-less homeobox protein 4b; homeobox protein Dlx4b", "tax_id": 7955, "disease": "orofacial cleft 15 (Disease Ontology:DOID:0080408)", "pathway": " (dre:30581)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15581883;23594743;25954033;37272628;8855272", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U67845.1, BC092714.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505384, SAMEA4476734 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U67845.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via bone morphogenic protein activity., [RefSeq, PubMed]; During larvae development, may be important for neurocranium morphogenesis., [UniProtKB, PubMed]; Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2GRG6;F1R2R2;Q568U7", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0021559 trigeminal nerve development;GO:0060119 inner ear receptor cell development;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q98878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98880-1", "uniprot_id": "ACHA_DANRE", "mass": 52100.0, "length": 456, "protein_name": "Acetylcholine receptor subunit alpha", "gene_name": "chrna1", "organism": "Zebrafish", "refseq_name": "acetylcholine receptor subunit alpha precursor", "refseq_ac": "NP_571520", "gene_names_uniprotkb": "chrna1; nic1", "gene_names_refseq": "chrna1; nic1; zgc:86593", "protein_names_uniprotkb": "Acetylcholine receptor subunit alpha", "protein_names_refseq": "AChR alpha 1; acetylcholine receptor subunit alpha precursor; acetylcholine receptor subunit alpha; cholinergic receptor, nicotinic, alpha polypeptide 1; nic-1; nicotinic acetylcholine receptor alpha-1; nicotinic receptor; nic", "tax_id": 7955, "disease": "congenital myasthenic syndrome 1B (Disease Ontology:DOID:0110662); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (dre:30725); (R-DRE-629594); (R-DRE-629597)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9475746", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U70438.1, BC081554.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U70438.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98SP7-1", "uniprot_id": "BBS2_DANRE", "mass": 79126.0, "length": 715, "protein_name": "BBSome complex member BBS2", "gene_name": "bbs2", "organism": "Zebrafish", "refseq_name": "BBSome complex member BBS2", "refseq_ac": "NP_690843", "gene_names_uniprotkb": "bbs2; fb80a05; wu:fb80a05", "gene_names_refseq": "bbs2; fb80a05; wu:fb80a05", "protein_names_uniprotkb": "BBSome complex member BBS2; Bardet-Biedl syndrome 2 protein homolog", "protein_names_refseq": "BBSome complex member BBS2; bardet-Biedl syndrome 2 protein homolog", "tax_id": 7955, "disease": "Bardet-Biedl syndrome 2 (Disease Ontology:DOID:0110124); retinitis pigmentosa 74 (Disease Ontology:DOID:0110401); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:259187); (R-DRE-5620922)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11285252", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF342739.1, BC075745.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF342739.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031514 motile cilium;GO:0043005 neuron projection;GO:0034451 centriolar satellite", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0070121 Kupffer's vesicle development;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98SP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98SR9-1", "uniprot_id": "TWS1B_DANRE", "mass": 24540.0, "length": 222, "protein_name": "Twisted gastrulation protein homolog 1-B", "gene_name": "twsg1b", "organism": "Zebrafish", "refseq_name": "twisted gastrulation protein homolog 1-B precursor", "refseq_ac": "NP_705958", "gene_names_uniprotkb": "twsg1b; tsg1; tsgb; ztsg1", "gene_names_refseq": "tsg1; tsgb; twsg1b; ztsg1", "protein_names_uniprotkb": "Twisted gastrulation protein homolog 1-B", "protein_names_refseq": "twisted gastrulation b; twisted gastrulation homolog 1b; twisted gastrulation protein homolog 1-B precursor; twisted gastrulation protein homolog 1-B", "tax_id": 7955, "disease": "", "pathway": " (dre:259304)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11260716;15525664;15604098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042330.1, CT619267.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Jun 30, 2025 this sequence version replaced XP_073796086.1, NP_705958.1., [RefSeq]; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd-independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization., [UniProtKB, PubMed, PubMed, PubMed]; Zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYN9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0001568 blood vessel development;GO:0030513 positive regulation of BMP signaling pathway;GO:0045765 regulation of angiogenesis;GO:0048264 determination of ventral identity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q98SR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98TU0-1", "uniprot_id": "GDNF_DANRE", "mass": 26829.0, "length": 235, "protein_name": "Glial cell line-derived neurotrophic factor", "gene_name": "gdnf", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gdnf", "gene_names_refseq": "", "protein_names_uniprotkb": "Glial cell line-derived neurotrophic factor; zGDNF", "protein_names_refseq": "", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Kennedy's disease (Disease Ontology:DOID:0060161); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); obsessive-compulsive disorder (Disease Ontology:DOID:10933); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); hyperprolactinemia (Disease Ontology:DOID:12700); Guillain-Barre syndrome (Disease Ontology:DOID:12842); Sjogren's syndrome (Disease Ontology:DOID:12894); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glomerulonephritis (Disease Ontology:DOID:2921); Churg-Strauss syndrome (Disease Ontology:DOID:3049); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); neuromuscular disease (Disease Ontology:DOID:440); amphetamine abuse (Disease Ontology:DOID:670); irritable bowel syndrome (Disease Ontology:DOID:9778); polyarteritis nodosa (Disease Ontology:DOID:9810); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-DRE-5673001); (R-DRE-8853659)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11237470", "class_list": "", "function": "Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:11237470). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0004709 MAP kinase kinase kinase activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030432 peristalsis;GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:0048484 enteric nervous system development;GO:0021536 diencephalon development;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q98TU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDD7-1", "uniprot_id": "SX19B_DANRE", "mass": 32218.0, "length": 292, "protein_name": "Transcription factor Sox-19b", "gene_name": "sox19b", "organism": "Zebrafish", "refseq_name": "transcription factor Sox-19b", "refseq_ac": "NP_571777", "gene_names_uniprotkb": "sox19b; sox31", "gene_names_refseq": "cb174; fb76c08; fe16f11; fe24f11; id:ibd3529; sb:cb174; sox19b; sox31; wu:fb76c08; wu:fe16f11; wu:fe24f11", "protein_names_uniprotkb": "Transcription factor Sox-19b; Protein sox-31", "protein_names_refseq": "SRY (sex determining region Y)-box 19b; SRY-box containing gene 19b; SRY-box containing gene 31; protein sox-31; transcription factor SOX19B; transcription factor Sox-19b", "tax_id": 7955, "disease": "", "pathway": " (dre:64812)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11118886;16408288;18307296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB242332.1, BC056835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476747, SAMEA4476752 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB242332.1. On Jul 24, 2006 this sequence version replaced XP_692852.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional activator., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2Z1Q8", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DDD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDE3-1", "uniprot_id": "ACES_DANRE", "mass": 71998.0, "length": 634, "protein_name": "Acetylcholinesterase", "gene_name": "ache", "organism": "Zebrafish", "refseq_name": "acetylcholinesterase precursor", "refseq_ac": "NP_571921", "gene_names_uniprotkb": "ache", "gene_names_refseq": "ache; zgc:92550", "protein_names_uniprotkb": "Acetylcholinesterase; 3.1.1.7; AChE", "protein_names_refseq": "acetylcholinesterase precursor; acetylcholinesterase; ziehharmonika; zim", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); leptospirosis (Disease Ontology:DOID:2297); multiple sclerosis (Disease Ontology:DOID:2377); myasthenia gravis (Disease Ontology:DOID:437); acute stress disorder (Disease Ontology:DOID:6088); subacute delirium (Disease Ontology:DOID:8645); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:114549)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11016933;15136152;16425445", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC163898.1, GFIL01000286.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Aryl acylamidase associated with acetylcholinesterase was higher than the esterase activity on zebrafishembryo, [RefSeq, PubMed]; Results demonstrate that AChE is dispensable for its proposed non-classical roles in muscle fiber formation and sensory neuron development, but is crucial for regulating the stability of neuromuscular synapses., [RefSeq, PubMed]; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.7", "go_molecular_function": "GO:0003990 acetylcholinesterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0019695 choline metabolic process;GO:0048484 enteric nervous system development;GO:0007528 neuromuscular junction development;GO:0045471 response to ethanol;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DDE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDJ0-1", "uniprot_id": "UBC9B_DANRE", "mass": 17936.0, "length": 157, "protein_name": "SUMO-conjugating enzyme UBC9-B", "gene_name": "ube2ib", "organism": "Zebrafish", "refseq_name": "SUMO-conjugating enzyme UBC9-B", "refseq_ac": "NP_571908", "gene_names_uniprotkb": "ube2ib; ubc9b; ube2i2", "gene_names_refseq": "Ubc9-2; ube2i2; ube2ia; ube2ib", "protein_names_uniprotkb": "SUMO-conjugating enzyme UBC9-B; 2.3.2.-; RING-type E3 SUMO transferase UBC9-B; SUMO-protein ligase B; Ubiquitin carrier protein 9-B; Ubiquitin carrier protein I-B; Ubiquitin-conjugating enzyme E2 I-B; Ubiquitin-protein ligase I-B", "protein_names_refseq": "RING-type E3 SUMO transferase UBC9-B; SUMO-conjugating enzyme UBC9-B; SUMO-protein ligase B; ubiquitin carrier protein 9-B; ubiquitin carrier protein I-B; ubiquitin-conjugating enzyme E2 I-B; ubiquitin-conjugating enzyme E2I2; ubiquitin-protein ligase I-B", "tax_id": 7955, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dre:114445)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11331779;17035631;25190811;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058302.1, EH451253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058302.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis., [UniProtKB, PubMed, PubMed]; Mutations in the zinc-binding domain of Apobec2 diminish its ability to stimulate Pou6f2 binding to DNA, and knockdown of Ubc9 or Pou6f2 suppressed retina regeneration Erratum:[J Biol Chem. 2015 Mar 6;290(10):6007. doi: 10.1074/jbc.A114.603043. PMID: 25750264], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0061656 SUMO conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036306 embryonic heart tube elongation;GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:0051301 cell division;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DDJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDK4-1", "uniprot_id": "S1PR1_DANRE", "mass": 40601.0, "length": 362, "protein_name": "Sphingosine 1-phosphate receptor 1", "gene_name": "s1pr1", "organism": "Zebrafish", "refseq_name": "sphingosine 1-phosphate receptor 1", "refseq_ac": "NP_571766", "gene_names_uniprotkb": "s1pr1; edg1", "gene_names_refseq": "edg1; etID43307.22; s1p1; s1pr1; wu:fb98f05", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; Sphingosine 1-phosphate receptor Edg-1", "protein_names_refseq": "S1P receptor 1; S1P receptor Edg-1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (dre:64617); (R-DRE-419408)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11112429;22837470;38096817", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075741.1, GDQQ01011470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476819, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1, EH440149.1 and EH598427.1. On Jan 26, 2016 this sequence version replaced NP_571766.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor., [RefSeq, PubMed]; G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate., [UniProtKB, PubMed]; Report role for S1PR1 in regulation venous endothelial barrier function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6DI49", "ec_number_list": "", "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity;GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DDK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DE24-1", "uniprot_id": "FXC1B_DANRE", "mass": 47918.0, "length": 433, "protein_name": "Forkhead box C1-B", "gene_name": "foxc1b", "organism": "Zebrafish", "refseq_name": "forkhead box C1-B", "refseq_ac": "NP_571804", "gene_names_uniprotkb": "foxc1b; foxc1.2", "gene_names_refseq": "foxc1.2; foxc1b; id:ibd5079", "protein_names_uniprotkb": "Forkhead box C1-B", "protein_names_refseq": "forkhead box C1-B", "tax_id": 7955, "disease": "anterior segment dysgenesis 3 (Disease Ontology:DOID:0080608); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); buphthalmos (Disease Ontology:DOID:11211); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); invasive ductal carcinoma (Disease Ontology:DOID:3008); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:79375)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11165495;17000708;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046028.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046028.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner., [UniProtKB, UniProtKB, UniProtKB]; This study reveals an important role for FOXC1 in the direct regulation of the FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0061300 cerebellum vasculature development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DE24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DE25-1", "uniprot_id": "FXC1A_DANRE", "mass": 52173.0, "length": 476, "protein_name": "Forkhead box C1-A", "gene_name": "foxc1a", "organism": "Zebrafish", "refseq_name": "forkhead box C1-A", "refseq_ac": "NP_571803", "gene_names_uniprotkb": "foxc1a; foxc1.1", "gene_names_refseq": "foxc1.1; foxc1a", "protein_names_uniprotkb": "Forkhead box C1-A", "protein_names_refseq": "forkhead box C1-A", "tax_id": 7955, "disease": "anterior segment dysgenesis 3 (Disease Ontology:DOID:0080608); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); buphthalmos (Disease Ontology:DOID:11211); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); invasive ductal carcinoma (Disease Ontology:DOID:3008); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:100148408)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11165495;17000708;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC053129.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FP149176.1, FP141849.1, CD281289.1 and CT690954.2. On Nov 10, 2009 this sequence version replaced XP_001918817.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner., [UniProtKB, UniProtKB, UniProtKB]; This study reveals an important role for FOXC1 in the direct regulation of the FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0061300 cerebellum vasculature development;GO:0061386 closure of optic fissure;GO:0035886 vascular associated smooth muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DE25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DE49-1", "uniprot_id": "PGFRA_DANRE", "mass": 118211.0, "length": 1059, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "pdgfra", "organism": "Zebrafish", "refseq_name": "platelet-derived growth factor receptor alpha precursor", "refseq_ac": "NP_571534", "gene_names_uniprotkb": "pdgfra; etID309717.20; pdgfr-a; wu:fc27f02; wu:fv91b12", "gene_names_refseq": "etID309717.20; pdgfr-a; pdgfra; wu:fc27f02; wu:fv91b12", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; PDGFR-alpha", "protein_names_refseq": "PDGF-R-alpha; PDGFR-alpha; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor alpha precursor; platelet-derived growth factor receptor alpha", "tax_id": 7955, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); craniopharyngioma (Disease Ontology:DOID:3840); brain stem glioma (Disease Ontology:DOID:4202); scimitar syndrome (Disease Ontology:DOID:4297); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); nephrolithiasis (Disease Ontology:DOID:585); chronic ulcer of skin (Disease Ontology:DOID:8549); myeloid sarcoma (Disease Ontology:DOID:8683); myeloid leukemia (Disease Ontology:DOID:8692); in situ carcinoma (Disease Ontology:DOID:8719); hypereosinophilic syndrome (Disease Ontology:DOID:999)", "pathway": " (dre:386856); (R-DRE-1257604); (R-DRE-186763); (R-DRE-186797); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "12128230;12211169", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01014724.1, GFIL01029830.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Aug 15, 2023 this sequence version replaced NP_571534.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation, [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric pdgfa, homodimeric pdgfb, heterodimers formed by pdgfa and pdgfb or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between pdgfra and pdgfrb. Phosphorylates pik3r1, plcg1, and ptpn11. Activation of plcg1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates pik3r1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of hras and of the MAP kinases mapk1/erk2 and/or mapk3/erk1. Promotes activation of STAT family members stat1, stat3 and stat5a and/or stat5b. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;3.6.5.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137;3.1.3.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0005018 platelet-derived growth factor alpha-receptor activity;GO:0048407 platelet-derived growth factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043235 receptor complex", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0061300 cerebellum vasculature development;GO:0006935 chemotaxis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DE49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DFH2-1", "uniprot_id": "Q9DFH2_DANRE", "mass": 51333.0, "length": 462, "protein_name": "Transcription factor SOX-9a", "gene_name": "sox9a", "organism": "Zebrafish", "refseq_name": "transcription factor SOX-9a", "refseq_ac": "NP_571718", "gene_names_uniprotkb": "sox9a; jef; wu:fj17b12; zgc:111921", "gene_names_refseq": "jef; sox9a; wu:fj17b12; zgc:111921", "protein_names_uniprotkb": "Transcription factor SOX-9a", "protein_names_refseq": "SRY (sex determining region Y)-box 9a; SRY-box containing gene 9a; SRY-like; involved in chondrogenesis and testis-determination; jellyfish; transcription factor SOX-9a", "tax_id": 7955, "disease": "campomelic dysplasia (Disease Ontology:DOID:0050463); 46,XX sex reversal 2 (Disease Ontology:DOID:0111763); 46,XY sex reversal 10 (Disease Ontology:DOID:0111775); lung cancer (Disease Ontology:DOID:1324); lung carcinoma (Disease Ontology:DOID:3905)", "pathway": " (dre:60641); (R-DRE-3769402); (R-DRE-8878166)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12397114;14503868;14579386;38710511;38731925;38970771;39215168;39397390;9007245;9007254", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF277096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476757, SAMEA4476761 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF277096.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Jef (sox9a) is essential for both morphogenesis of condensations and overt cartilage differentiation Erratum:[Development 2002 Dec;129(23):5551. Nissen Robert [corrected to Nissen Robert M]], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78AH9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0014029 neural crest formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DFH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DFS6-1", "uniprot_id": "IF4EA_DANRE", "mass": 24850.0, "length": 215, "protein_name": "Eukaryotic translation initiation factor 4E-1A", "gene_name": "eif4ea", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 4E-1A", "refseq_ac": "NP_571808", "gene_names_uniprotkb": "eif4ea", "gene_names_refseq": "eif4e-1; eif4e1a; eif4ea; eif4e; zgc:86680", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-1A; eIF4E-1A; mRNA cap-binding protein", "protein_names_refseq": "eIF4E-1A; eukaryotic translation initiation factor 4E-1A; eukaryotic translation initiation factor 4e 1a; eukaryotic translation initiation factor eIF4E-1; mRNA cap-binding protein", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); candidiasis (Disease Ontology:DOID:1508); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (dre:79380); (R-DRE-156827); (R-DRE-159227); (R-DRE-159231); (R-DRE-166208); (R-DRE-72649); (R-DRE-72662); (R-DRE-72702)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "14701818", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF257519.1, BC071364.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF257519.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:14701818). Also promotes export of a subset of mRNAs from the nucleus to the cytoplasm (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DFS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGD9-1", "uniprot_id": "MK08_DANRE", "mass": 44140.0, "length": 384, "protein_name": "Mitogen-activated protein kinase 8", "gene_name": "mapk8", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase 8", "refseq_ac": "NP_571796", "gene_names_uniprotkb": "mapk8; jnk1", "gene_names_refseq": "JNK1; JNK; jnk1a-1; jnk1b; mapk8b; mapk8; zgc:112379", "protein_names_uniprotkb": "Mitogen-activated protein kinase 8; 2.7.11.24; MAP kinase 8; MAPK 8; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1", "protein_names_refseq": "MAP kinase 8; MAPK 8; c-Jun N-terminal kinase 1; mitogen-activated protein kinase 8; stress-activated protein kinase JNK1", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); rectal benign neoplasm (Disease Ontology:DOID:1984); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:65236); (R-DRE-193648); (R-DRE-2559580); (R-DRE-2871796); (R-DRE-450321); (R-DRE-450341); (R-DRE-5693565); (R-DRE-9007892)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10995439;17681137;18641354", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB030900.1, SRR32588715.283716.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined., [RefSeq, PubMed]; JNK-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo, [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;3.2.2.6", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004705 JUN kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0007254 JNK cascade;GO:0048511 rhythmic process;GO:0048263 determination of dorsal identity;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DGD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGE0-1", "uniprot_id": "MP2K6_DANRE", "mass": 40594.0, "length": 361, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6", "gene_name": "map2k6", "organism": "Zebrafish", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 6", "refseq_ac": "NP_001299799", "gene_names_uniprotkb": "map2k6; MKK3; map2k3; zMKK3", "gene_names_refseq": "MKK3; map2k3; map2k6; zMKK3", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 6; 2.7.12.2; MAP kinase kinase 6; MAPKK 6; Mitogen-activated protein kinase kinase 3; zMKK3", "protein_names_refseq": "dual specificity mitogen-activated protein kinase kinase 6", "tax_id": 7955, "disease": "Pick's disease (Disease Ontology:DOID:11870); Parkinson's disease (Disease Ontology:DOID:14330); restrictive cardiomyopathy (Disease Ontology:DOID:397); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); progressive supranuclear palsy (Disease Ontology:DOID:678); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:65239); (R-DRE-168638); (R-DRE-2559580); (R-DRE-450302); (R-DRE-9833482)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "10995439", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044129.1, GDQH01002347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is necessary for blastomere cleavage., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IQW6", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;2.3.2.27", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000165 MAPK cascade;GO:1900745 positive regulation of p38MAPK cascade;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DGE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8K8-1", "uniprot_id": "S1PR2_DANRE", "mass": 41777.0, "length": 370, "protein_name": "Sphingosine 1-phosphate receptor 2", "gene_name": "s1pr2", "organism": "Zebrafish", "refseq_name": "sphingosine 1-phosphate receptor 2", "refseq_ac": "NP_001153442", "gene_names_uniprotkb": "s1pr2; edg5", "gene_names_refseq": "edg5; mil; s1p2; s1pr2", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P receptor Edg-5; S1P2; Sphingosine 1-phosphate receptor Edg-5", "protein_names_refseq": "S1P receptor 2; S1P receptor Edg-5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; miles apart; sphingosine 1-phosphate receptor 2; sphingosine 1-phosphate receptor Edg-5", "tax_id": 7955, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); autosomal recessive nonsyndromic deafness 68 (Disease Ontology:DOID:0110519); carcinoma (Disease Ontology:DOID:305)", "pathway": " (dre:170457); (R-DRE-418594); (R-DRE-419408)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10910360", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01034322.1, GDQQ01065171.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505387 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000003.1. On May 7, 2009 this sequence version replaced XP_682912.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10910360). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis (PubMed:10910360). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0030336 negative regulation of cell migration;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9I8K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8V2-1", "uniprot_id": "SMAD1_DANRE", "mass": 53066.0, "length": 472, "protein_name": "SMAD family member 1", "gene_name": "smad1", "organism": "Zebrafish", "refseq_name": "SMAD family member 1", "refseq_ac": "NP_571431", "gene_names_uniprotkb": "smad1; madh1", "gene_names_refseq": "fb39h09; madh1; sb:eu786; smad1; wu:fb39h09; wu:fb97e04", "protein_names_uniprotkb": "SMAD family member 1; MAD homolog 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; SMAD 1", "protein_names_refseq": "MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; SMA- and MAD-related protein 1; SMAD family member 1; mothers against DPP homolog 1; mothers against decapentaplegic homolog 1", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); nephrotic syndrome (Disease Ontology:DOID:1184); male infertility (Disease Ontology:DOID:12336); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:30628); (R-DRE-201451); (R-DRE-5689880)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10525190;10590480", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006281.1, BC086962.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Sep 12, 2018 this sequence version replaced XP_005160022.1, NP_571431.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PUQ3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I8V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9L0-1", "uniprot_id": "HEY2_DANRE", "mass": 34329.0, "length": 324, "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "hey2", "organism": "Zebrafish", "refseq_name": "hairy/enhancer-of-split related with YRPW motif protein 2", "refseq_ac": "NP_571697", "gene_names_uniprotkb": "hey2; grl; zgc:136746", "gene_names_refseq": "grl; hey2; zgc:136746", "protein_names_uniprotkb": "Hairy/enhancer-of-split related with YRPW motif protein 2; Protein gridlock", "protein_names_refseq": "Herp2; hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2; protein gridlock", "tax_id": 7955, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); aortic valve disease (Disease Ontology:DOID:62); tetralogy of Fallot (Disease Ontology:DOID:6419); varicose veins (Disease Ontology:DOID:799)", "pathway": " (dre:58146)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10710309;11700560;14593478", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF237948.1, BC114263.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF237948.1 and BC114263.1. On Mar 24, 2009 this sequence version replaced NP_571697.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24JW1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072359 circulatory system development;GO:0061026 cardiac muscle tissue regeneration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9I9L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9L7-1", "uniprot_id": "CASPA_DANRE", "mass": 43966.0, "length": 383, "protein_name": "Caspase a", "gene_name": "caspa", "organism": "Zebrafish", "refseq_name": "caspase a", "refseq_ac": "NP_571580", "gene_names_uniprotkb": "caspa; casp1; caspy; fa93b02; wu:fa93b02; zgc:109869", "gene_names_refseq": "casp1; caspa; caspy; fa93b02; wu:fa93b02; zgc:109869", "protein_names_uniprotkb": "Caspase a; 3.4.22.36", "protein_names_refseq": "caspase 1; caspase a", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); in situ carcinoma (Disease Ontology:DOID:8719); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:57933); (R-DRE-9948001); (R-DRE-9948011); (R-DRE-9960519); (R-DRE-9960525)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10917738;12464617;23594743;28402832;29123523;29791492;29791979;30150286;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC095022.1, AF233434.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095022.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Role in pharyngeal arch development, [RefSeq, PubMed]; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis (PubMed:12464617, PubMed:30150286). Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation (PubMed:30150286). In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form (PubMed:30150286). Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu (PubMed:30150286). Required for the development of the cartilaginous pharyngeal skeleton (PubMed:12464617)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2U9DQN4", "ec_number_list": "3.6.5.-;3.4.22.58;3.4.22.36", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0032090 Pyrin domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072558 NLRP1 inflammasome complex;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0050729 positive regulation of inflammatory response;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9I9L7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9N6-1", "uniprot_id": "ASC_DANRE", "mass": 22867.0, "length": 203, "protein_name": "Apoptosis-associated speck-like protein containing a CARD", "gene_name": "pycard", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pycard; ASC; asc1; asc; zAsc; zgc:109874", "gene_names_refseq": "", "protein_names_uniprotkb": "Apoptosis-associated speck-like protein containing a CARD; PYD and CARD domain-containing protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:57923); (R-DRE-111458); (R-DRE-6798695); (R-DRE-844455); (R-DRE-844456); (R-DRE-9627069)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10917738;11250163;12464617;17850868;19699229;22988238;27363812;29123523;29791979;30150286;36112693;36587712;36640321;37813860;38535441;40044042", "class_list": "", "function": "Functions as a key mediator in apoptosis and inflammation (PubMed:12464617, PubMed:30150286). Promotes caspase-mediated apoptosis (PubMed:12464617). Induces proteolytic processing of caspa and caspa-dependent apoptosis (PubMed:12464617). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:30150286). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (PubMed:30150286). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032090 Pyrin domain binding;GO:0038187 pattern recognition receptor activity;GO:0140608 cysteine-type endopeptidase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072559 NLRP3 inflammasome complex;GO:0061702 canonical inflammasome complex;GO:0140738 NLRP6 inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050727 regulation of inflammatory response;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9I9N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9R3-1", "uniprot_id": "S40A1_DANRE", "mass": 61765.0, "length": 562, "protein_name": "Solute carrier family 40 member 1", "gene_name": "slc40a1", "organism": "Zebrafish", "refseq_name": "solute carrier family 40 member 1", "refseq_ac": "NP_571704", "gene_names_uniprotkb": "slc40a1; fpn1; slc39a1", "gene_names_refseq": "FPN1; slc39a1; slc40a1; weh", "protein_names_uniprotkb": "Solute carrier family 40 member 1; Ferroportin-1", "protein_names_refseq": "ferroportin-1; ferroportin1; iron-regulated transporter; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1; solute carrier family 40 member 1; weissherbst", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); hemochromatosis type 4 (Disease Ontology:DOID:0111028); iron deficiency anemia (Disease Ontology:DOID:11758); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:58153); (R-DRE-425410); (R-DRE-917937)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10693807;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF226612.1, BC163874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF226612.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:10693807). May be involved in transfer of Fe(2+) between maternal and fetal circulation (PubMed:10693807)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B729;Q7ZZ51;Q8AW23;Q8AW28;Q8JFW0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0046688 response to copper ion;GO:0010039 response to iron ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I9R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAT6-1", "uniprot_id": "DLLC_DANRE", "mass": 72548.0, "length": 664, "protein_name": "Delta-like protein C", "gene_name": "dlc", "organism": "Zebrafish", "refseq_name": "delta-like protein C precursor", "refseq_ac": "NP_571019", "gene_names_uniprotkb": "dlc", "gene_names_refseq": "delC; dlc", "protein_names_uniprotkb": "Delta-like protein C; DeltaC; delC", "protein_names_refseq": "beamter; bea; delta-like protein C precursor; delta-like protein C", "tax_id": 7955, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (dre:30120)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10585570;11100729", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF146429.1, CU458991.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF146429.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0048514 blood vessel morphogenesis;GO:0001756 somitogenesis;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9IAT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAV3-1", "uniprot_id": "HHEX_DANRE", "mass": 26048.0, "length": 228, "protein_name": "Hematopoietically-expressed homeobox protein hhex", "gene_name": "hhex", "organism": "Zebrafish", "refseq_name": "hematopoietically-expressed homeobox protein hhex", "refseq_ac": "NP_571009", "gene_names_uniprotkb": "hhex; hex", "gene_names_refseq": "hex; hhex", "protein_names_uniprotkb": "Hematopoietically-expressed homeobox protein hhex; Homeobox protein hex", "protein_names_refseq": "hematopoietically-expressed homeobox protein hhex; homeobox protein hex", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30098)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10531010;11003831;11477693;14568547;15581885", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF131070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF131070.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that zebrafish hhex appears to be activated by Wnt/beta-catenin in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2., [RefSeq, PubMed]; Hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors., [RefSeq, PubMed]; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0035162 embryonic hemopoiesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9IAV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AW41-1", "uniprot_id": "Q8AW41_DANRE", "mass": 31091.0, "length": 265, "protein_name": "Transcription factor PU.1b isoform 3", "gene_name": "spi1b", "organism": "Zebrafish", "refseq_name": "transcription factor PU.1b isoform 3", "refseq_ac": "NP_001315298", "gene_names_uniprotkb": "spi1b; cb1086; pu.1; pu1; sfpi1; si:by184l24.2; spi1", "gene_names_refseq": "cb1086; pu.1; pu1; sfpi1; si:by184l24.2; spi1b; spi1", "protein_names_uniprotkb": "Transcription factor PU.1b isoform 3", "protein_names_refseq": "spleen focus forming virus (SFFV) proviral integration oncogene spi1b; spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1b isoform 3; transcription factor spi1", "tax_id": 7955, "disease": "agammaglobulinemia 10 (Disease Ontology:DOID:0081142); alcohol use disorder (Disease Ontology:DOID:1574); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:30117)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11468162;11830566;12051816;12869502;39138265;39177514;39178124;39196933;39558430;9671819", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.31227945.1, SRR32588714.47138491.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476753, SAMEA4476757 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 16, 2016 this sequence version replaced XP_005168907.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal LPM., [RefSeq, PubMed]; The promoter of this gene has been isolated and characterized, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P911", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8AW41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W7R3-1", "uniprot_id": "TEN4_DANRE", "mass": 313506.0, "length": 2824, "protein_name": "Teneurin-4", "gene_name": "tenm4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tenm4; odz4; ten-4; ten-m4; tnm4", "gene_names_refseq": "", "protein_names_uniprotkb": "Teneurin-4; Protein Odd Oz/ten-m homolog 4; Ten-4; Ten-m4; Tenascin-M4; Teneurin transmembrane protein 4", "protein_names_refseq": "", "tax_id": 7955, "disease": "essential tremor 5 (Disease Ontology:DOID:0111432)", "pathway": " (dre:30156)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10495292;19433629;26188006;27189481;28252024;30914911;33071966;33621777", "class_list": "", "function": "Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 18, "predicted_n_glycosites": 16, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9W7R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PW80-1", "uniprot_id": "IF2B3_DANRE", "mass": 63352.0, "length": 582, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 3", "gene_name": "igf2bp3", "organism": "Zebrafish", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 3", "refseq_ac": "NP_571566", "gene_names_uniprotkb": "igf2bp3; dvr1rbp; vickz3; wu:fb79c12; wu:fe06h09; zVg1RBP", "gene_names_refseq": "dvr1rbp; igf2bp3; wu:fb79c12; wu:fe06h09; zVg1RBP", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 3; Decapentaplegic and Vg-related 1 RNA-binding protein; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; VICKZ family member 3; Vg1 RNA-binding protein; Vg1-RBP", "protein_names_refseq": "IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IMP3; VICKZ family member 3; Vg1 RBP; decapentaplegic and Vg-related 1 RNA-binding protein; insulin-like growth factor 2 mRNA-binding protein 3; vg1 RNA-binding protein; vg1-RBP", "tax_id": 7955, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158)", "pathway": " (dre:30967)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10525193;14522877;15601260;18307296;32127635;34214072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045873.1, AF161270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045873.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Involved in neuronal crest migration (PubMed:14522877)., [UniProtKB, UniProtKB, PubMed]; The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007530 sex determination;GO:0070934 CRD-mediated mRNA stabilization;GO:0006417 regulation of translation;GO:0007399 nervous system development;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9PW80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PVE4-1", "uniprot_id": "THB_DANRE", "mass": 45155.0, "length": 395, "protein_name": "Thyroid hormone receptor beta", "gene_name": "thrb", "organism": "Zebrafish", "refseq_name": "thyroid hormone receptor beta", "refseq_ac": "NP_571415", "gene_names_uniprotkb": "thrb; NR1A2; TR-beta; TR[b]1; fj24f03; nr1a2; si:ch211-264a6.2; thr2; trb; wu:fj24f03", "gene_names_refseq": "NR1A2; TR-beta; TR[b]1; fj24f03; thr2; thrb; trb; wu:fj24f03", "protein_names_uniprotkb": "Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; TR-beta; TRbeta1; TRb; Thyroid hormone receptor beta-1", "protein_names_refseq": "TRbeta1; nuclear receptor subfamily 1 group A member 2; thyroid hormone receptor beta 2; thyroid hormone receptor beta-1; thyroid hormone receptor beta", "tax_id": 7955, "disease": "selective pituitary thyroid hormone resistance (Disease Ontology:DOID:0111374); prostate cancer (Disease Ontology:DOID:10283); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:30607); (R-DRE-383280); (R-DRE-4090294)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10687864;11174854;11738632;11963654;17418841;17997606;18248177;23594743;9192646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF109732.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109732.1. On Jul 6, 2005 this sequence version replaced XP_692982.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that the embryonic to larval transitory phase is characterized by its dependency on the timely synthesis of thyroid hormone and the concomitant autoinductive increase in thyroid hormone receptor beta mRNA levels., [RefSeq, PubMed]; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3QJW1;B3DIF2;O42560;Q90Y31", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070324 thyroid hormone binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9PVE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YHV4-1", "uniprot_id": "FSTA_DANRE", "mass": 35517.0, "length": 322, "protein_name": "Follistatin-A", "gene_name": "fsta", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "fsta; cb446; fd07h10; fst1; fst; fs; si:dkey-111k10.2; si:dkeyp-88a5.1; wu:fd07h10", "gene_names_refseq": "", "protein_names_uniprotkb": "Follistatin-A; Activin-binding protein; FS; Follistatin-1; zFst1", "protein_names_refseq": "", "tax_id": 7955, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (dre:100004116); (R-DRE-2473224)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16890217;23594743;9882485", "class_list": "", "function": "Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A5PMK3;A7MC96;Q6DC45", "ec_number_list": "", "go_molecular_function": "GO:0048185 activin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0030154 cell differentiation;GO:0032926 negative regulation of activin receptor signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030510 regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9YHV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YGW7-1", "uniprot_id": "DAZL_DANRE", "mass": 25548.0, "length": 229, "protein_name": "Deleted in azoospermia-like", "gene_name": "dazl", "organism": "Zebrafish", "refseq_name": "deleted in azoospermia-like", "refseq_ac": "NP_571599", "gene_names_uniprotkb": "dazl; zdazl", "gene_names_refseq": "dazl", "protein_names_uniprotkb": "Deleted in azoospermia-like; DAZ-like protein; zDazl", "protein_names_refseq": "DAZ-like protein; deleted in azoospermia-like", "tax_id": 7955, "disease": "", "pathway": " (dre:58039)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10330505;12296827;18582455;24496621", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB018191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB018191.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates., [RefSeq, PubMed]; RNA-binding protein involved in gametogenesis in both males and females (PubMed:12296827). Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (PubMed:12296827). Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008494 translation activator activity;GO:0043565 sequence-specific DNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9YGW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PUQ1-1", "uniprot_id": "ETV4_DANRE", "mass": 55621.0, "length": 494, "protein_name": "ETS translocation variant 4", "gene_name": "etv4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "etv4; pea3", "gene_names_refseq": "", "protein_names_uniprotkb": "ETS translocation variant 4; Polyomavirus enhancer activator 3 homolog; Protein PEA3", "protein_names_refseq": "", "tax_id": 7955, "disease": "bipolar disorder (Disease Ontology:DOID:3312); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30700)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10534622;11413000;11520667;12641569;12810598;15151985;36458546;36520654;37665167;38165177;38423763;9671318", "class_list": "", "function": "Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O57586", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9PUQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQB1-1", "uniprot_id": "A0A8M3AQB1_DANRE", "mass": 103705.0, "length": 907, "protein_name": "Type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1", "gene_name": "inpp5b", "organism": "Zebrafish", "refseq_name": "type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1", "refseq_ac": "XP_009290335", "gene_names_uniprotkb": "inpp5b", "gene_names_refseq": "inpp5b", "protein_names_uniprotkb": "Type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1", "protein_names_refseq": "type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563543)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009290335.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0052745 inositol phosphate phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0031901 early endosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0060271 cilium assembly;GO:0039023 pronephric duct morphogenesis;GO:0070121 Kupffer's vesicle development;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AQB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YGX5-1", "uniprot_id": "CPEB1_DANRE", "mass": 62255.0, "length": 559, "protein_name": "Cytoplasmic polyadenylation element-binding protein 1", "gene_name": "cpeb1b; cpeb1", "organism": "Zebrafish", "refseq_name": "cytoplasmic polyadenylation element-binding protein 1", "refseq_ac": "NP_571502", "gene_names_uniprotkb": "cpeb1b; cpeb1; ZOR-1; cepb1b; cpeb1; fd15c06; wu:fd15c06; zor1; zorba", "gene_names_refseq": "ZOR-1; cepb1b; cpeb1b; cpeb1; fd15c06; wu:fd15c06; zorba", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element-binding protein 1; CPE-BP1; CPE-binding protein 1; CPEB-1; Orb/CPEB-related RNA-binding protein; Protein Zorba; ZOR-1; Zebrafish orb-type a", "protein_names_refseq": "CPE-BP1; CPE-binding protein 1; CPEB-1; Orb/CPEB-related RNA-binding protein; cytoplasmic polyadenylation element-binding protein 1; protein Zorba; zebrafish orb-type a", "tax_id": 7955, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); glioblastoma (Disease Ontology:DOID:3068); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dre:30702)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9784598", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01024618.1, BC045467.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH503358.1, AB011680.1 and JBMGRA010000007.1. On Jun 16, 2015 this sequence version replaced NP_571502.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93386", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0032869 cellular response to insulin stimulus;GO:0071456 cellular response to hypoxia;GO:0071230 cellular response to amino acid stimulus;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YGX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ART8-1", "uniprot_id": "A0A8M3ART8_DANRE", "mass": 69268.0, "length": 610, "protein_name": "Telomeric repeat binding factor a isoform X1", "gene_name": "terfa", "organism": "Zebrafish", "refseq_name": "telomeric repeat binding factor a isoform X1", "refseq_ac": "XP_009299378", "gene_names_uniprotkb": "terfa; CHUNP6903; wu:fi15d05; wu:fi22b03; zgc:111909; zgc:114011", "gene_names_refseq": "CHUNP6903; terfa; wu:fi15d05; wu:fi22b03; zgc:111909; zgc:114011", "protein_names_uniprotkb": "Telomeric repeat binding factor a isoform X1", "protein_names_refseq": "telomeric repeat binding factor a isoform X1", "tax_id": 7955, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427)", "pathway": " (dre:192316)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21209837;24240475;26469318;27189481;28437249;30837464;33984809;34214617;35150283", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042162 telomeric DNA binding;GO:0003691 double-stranded telomeric DNA binding;GO:0098505 G-rich strand telomeric DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:0070187 shelterin complex", "go_biological_process": "GO:0031848 protection from non-homologous end joining at telomere;GO:0006278 RNA-templated DNA biosynthetic process;GO:0070198 protein localization to chromosome, telomeric region;GO:0061820 telomeric D-loop disassembly;GO:0032210 regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M3ART8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "U3JAG9-1", "uniprot_id": "CP131_DANRE", "mass": 128302.0, "length": 1113, "protein_name": "Centrosomal protein of 131 kDa", "gene_name": "cep131", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "cep131; azi1", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 131 kDa; 5-azacytidine-induced protein 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (dre:563066); (R-DRE-380320)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19254375;23594743;24550735;27189481;35929537;37867960", "class_list": "", "function": "Cilium-specific protein required for the regulation of cilium/flagellum formation (PubMed:19254375). Involved in centriole duplication (By similarity). May play a role in melanosome trafficking (PubMed:24550735)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08CN2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0000775 chromosome, centromeric region;GO:0001669 acrosomal vesicle;GO:0034451 centriolar satellite", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0030154 cell differentiation;GO:0060271 cilium assembly;GO:0070121 Kupffer's vesicle development;GO:0090317 negative regulation of intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "U3JAG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6G6-1", "uniprot_id": "SEM3D_DANRE", "mass": 87860.0, "length": 764, "protein_name": "Semaphorin-3D", "gene_name": "sema3d", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "sema3d; sema2; semaZ2; semaz2", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-3D; Sema Z2; Semaphorin-2; Semaphorin-Z2", "protein_names_refseq": "", "tax_id": 7955, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (dre:30250)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10821754;14724229;15456815;15882579;16033800;32990594;33925390;35940453;36513650;37507475;9915572", "class_list": "", "function": "May play a role in the guidance of several axon pathways., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W6G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6T7-1", "uniprot_id": "PSN1_DANRE", "mass": 50981.0, "length": 456, "protein_name": "Presenilin-1", "gene_name": "psen1", "organism": "Zebrafish", "refseq_name": "presenilin-1", "refseq_ac": "NP_571099", "gene_names_uniprotkb": "psen1; pre1; psen; zf-PS1; zfPS1", "gene_names_refseq": "pre1; psen1; psen; zf-PS1; zfPS1", "protein_names_uniprotkb": "Presenilin-1; 3.4.23.-; PS-1; Zf-PS1", "protein_names_refseq": "PS-1; presenilin-1", "tax_id": 7955, "disease": "frontotemporal dementia 1 (Disease Ontology:DOID:0051060); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1U (Disease Ontology:DOID:0110455); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (dre:30221); (R-DRE-1251985); (R-DRE-193692); (R-DRE-3928665); (R-DRE-6798695); (R-DRE-9839383)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10521267;37946213;38509077", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ132931.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505382, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ132931.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10521267). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity)., [UniProtKB, UniProtKB, PubMed]; METTL3-dependent m[6]A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/beta-catenin signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.5.1.18;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.6.5.2;3.4.23.-", "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0052548 regulation of endopeptidase activity;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W6T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PTJ3-1", "uniprot_id": "RBTN2_DANRE", "mass": 18455.0, "length": 159, "protein_name": "Rhombotin-2", "gene_name": "lmo2", "organism": "Zebrafish", "refseq_name": "rhombotin-2", "refseq_ac": "NP_571186", "gene_names_uniprotkb": "lmo2; si:dkey-10o6.5", "gene_names_refseq": "lmo2; wu:fc83a08; zgc:111930", "protein_names_uniprotkb": "Rhombotin-2; LIM domain only protein 2; LMO-2; zlmo2", "protein_names_refseq": "LIM domain only protein 2; LIM domain only-2; LMO-2; rhombotin-2; ttg2; zlmo2", "tax_id": 7955, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:30332); (R-DRE-8939236)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14602685;15893977;17090656;23594743;9630750", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF191560.1, GDQQ01009093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; In the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells, [RefSeq, PubMed]; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q567L0", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0001568 blood vessel development;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9PTJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PUB8-1", "uniprot_id": "S39A7_DANRE", "mass": 47467.0, "length": 444, "protein_name": "Zinc transporter Slc39a7", "gene_name": "slc39a7", "organism": "Zebrafish", "refseq_name": "zinc transporter Slc39a7 precursor", "refseq_ac": "NP_571006", "gene_names_uniprotkb": "slc39a7; hke4; ke4", "gene_names_refseq": "HKE4; ZIP7; id:ibd5081; ke4; slc39a7; wu:fc28c09", "protein_names_uniprotkb": "Zinc transporter Slc39a7; Histidine-rich membrane protein Ke4; Solute carrier family 39 member 7; ZIP7; Zrt-, Irt-like protein 7", "protein_names_refseq": "histidine-rich membrane protein Ke4; solute carrier family 39 (zinc transporter), member 7; zinc transporter Slc39a7 precursor; zinc transporter Slc39a7; zrt-, Irt-like protein 7", "tax_id": 7955, "disease": "agammaglobulinemia 9 (Disease Ontology:DOID:0081141)", "pathway": " (dre:30094); (R-DRE-442380)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22912764;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076241.1, GFIL01038660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH509633.1, JBMGRA010000019.1 and EH611820.1. On Apr 11, 2018 this sequence version replaced NP_571006.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (By similarity). Plays a role in maintaining zinc homeostasis and organism development especially in eyes, brain, and gills (PubMed:22912764)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KPZ7", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0098773 skin epidermis development;GO:0006829 zinc ion transport;GO:0030183 B cell differentiation;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PUB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PVF7-1", "uniprot_id": "PLAKA_DANRE", "mass": 80033.0, "length": 729, "protein_name": "Junction plakoglobin a", "gene_name": "jupa", "organism": "Zebrafish", "refseq_name": "junction plakoglobin a", "refseq_ac": "NP_571252", "gene_names_uniprotkb": "jupa; cb80; danPG; fb11b06; jup; wu:fb11b06", "gene_names_refseq": "cb80; danPG; fb11b06; jupa; jup; wu:fb11b06", "protein_names_uniprotkb": "Junction plakoglobin a; Gamma-catenin; Plakoglobin-1a; Plakoglobin", "protein_names_refseq": "armadillo protein family; gama-catenin; gamma-catenin; junction plakoglobin a; plakoglobin-1a; plakoglobin", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); endometrial hyperplasia (Disease Ontology:DOID:0080365); Naxos disease (Disease Ontology:DOID:0080551); arrhythmogenic right ventricular dysplasia 12 (Disease Ontology:DOID:0110083); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); palmoplantar keratosis (Disease Ontology:DOID:3390); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603); neuropathy (Disease Ontology:DOID:870); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30415); (R-DRE-5218920); (R-DRE-6798695); (R-DRE-6805567); (R-DRE-6809371); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106); (R-DRE-9013148); (R-DRE-9013406); (R-DRE-9013407); (R-DRE-9764561); (R-DRE-9766229); (R-DRE-9768727); (R-DRE-9958825)", "pathway_count": 15, "publication_count": 10, "publication_id_list": "10456847;15494018;18682726;19101534;23594743;25692557;26938059;27760340;29376824;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF099738.1, BC058305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF099738.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Common junctional plaque protein (By similarity). Required for Kupffer's vesicle lumen fluid retention and expansion during embryogenesis via maintenance of cell-cell adhesion junction integrity (PubMed:29376824). Plays an important role in cell-cell adhesion via maintenance of desmosome and adherens junctions in the heart and is thereby required for heart and vasculature development, potentially via regulation of the Wnt signaling pathway (PubMed:19101534)., [UniProtKB, PubMed, PubMed, UniProtKB]; Knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted tail, [RefSeq, PubMed]; Plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0045296 cadherin binding;GO:0019903 protein phosphatase binding;GO:0045294 alpha-catenin binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0098609 cell-cell adhesion;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9PVF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PVF8-1", "uniprot_id": "CTNA1_DANRE", "mass": 100519.0, "length": 907, "protein_name": "Catenin alpha-1", "gene_name": "ctnna1", "organism": "Zebrafish", "refseq_name": "catenin alpha-1", "refseq_ac": "NP_571531", "gene_names_uniprotkb": "ctnna1; ctnna", "gene_names_refseq": "ctnna1; ctnna", "protein_names_uniprotkb": "Catenin alpha-1; Alpha E-catenin", "protein_names_refseq": "[a]E-catenin; alpha E-catenin; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1", "tax_id": 7955, "disease": "patterned macular dystrophy 2 (Disease Ontology:DOID:0060864); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive lobular carcinoma (Disease Ontology:DOID:3457); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dre:30741); (R-DRE-5218920); (R-DRE-525793); (R-DRE-5626467); (R-DRE-9764561); (R-DRE-9958825)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10456847;16319113;19582161;20371743;20736288;23594743;27612508", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066669.1, AF099737.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Associates with the cytoplasmic domain of a variety of cadherins, forming catenin and cadherin complexes which are further linked to the actin filament network and is thereby involved in cell-cell adhesion (By similarity). Required for embryonic development, via maintenance of adherens junctions that facilitate the maintenance of the epithelial barrier (PubMed:27612508)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IH88;Q6NYB2", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0016477 cell migration;GO:0001894 tissue homeostasis;GO:0098609 cell-cell adhesion;GO:0034334 adherens junction maintenance;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9PVF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5Z2-1", "uniprot_id": "PITX2_DANRE", "mass": 35187.0, "length": 314, "protein_name": "Pituitary homeobox 2", "gene_name": "pitx2", "organism": "Zebrafish", "refseq_name": "pituitary homeobox 2", "refseq_ac": "NP_571050", "gene_names_uniprotkb": "pitx2; pitx2a; pitx2b; pitx2c; zgc:110508", "gene_names_refseq": "pitx2a; pitx2c; pitx2; zgc:110508", "protein_names_uniprotkb": "Pituitary homeobox 2; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2", "protein_names_refseq": "homeobox protein PITX2; paired-like homeodomain transcription factor 2a; pituitary homeobox 2; pitx2b", "tax_id": 7955, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); anterior segment dysgenesis 4 (Disease Ontology:DOID:0080609); Axenfeld-Rieger syndrome type 1 (Disease Ontology:DOID:0110120); ring dermoid of cornea (Disease Ontology:DOID:0111548); hypothyroidism (Disease Ontology:DOID:1459); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:30164)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10500184;10521397;10662647", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF132446.1, BC092922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF132446.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Regulates mesendoderm formation and the establishment of left-right asymmetry in the developing embryo., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q568C4;Q9W5Z1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0061386 closure of optic fissure;GO:0021501 prechordal plate formation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043114 regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W5Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W686-1", "uniprot_id": "SE3AB_DANRE", "mass": 88905.0, "length": 778, "protein_name": "Semaphorin-3ab", "gene_name": "sema3ab", "organism": "Zebrafish", "refseq_name": "semaphorin-3ab precursor", "refseq_ac": "NP_571136", "gene_names_uniprotkb": "sema3ab; sema1b; sema3a2; semaZ1b; semaz1b", "gene_names_refseq": "sema1b; sema3a2; sema3ab; semaZ1b", "protein_names_uniprotkb": "Semaphorin-3ab; Sema Z1B; Semaphorin-1B; Semaphorin-Z1B", "protein_names_refseq": "sema Z1B; semaphorin 1b; semaphorin-1B; semaphorin-3ab precursor; semaphorin-3ab; semaphorin-Z1B", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 16 with or without anosmia (Disease Ontology:DOID:0090080)", "pathway": " (dre:30267); (R-DRE-399954); (R-DRE-399956)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10495275", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF083382.1, BC163261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF083382.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0001569 branching involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W686-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6A5-1", "uniprot_id": "OPSG1_DANRE", "mass": 38844.0, "length": 349, "protein_name": "Green-sensitive opsin-1", "gene_name": "opn1mw1", "organism": "Zebrafish", "refseq_name": "green-sensitive opsin-1", "refseq_ac": "NP_571328", "gene_names_uniprotkb": "opn1mw1; grops1; rh21", "gene_names_refseq": "RH2-1; grops1; opn1mw1; rh2.1; zfgr1", "protein_names_uniprotkb": "Green-sensitive opsin-1; Green cone photoreceptor pigment 1; Opsin RH2-1; Opsin-1, medium-wave-sensitive 1", "protein_names_refseq": "green cone photoreceptor pigment 1; green-sensitive opsin-1; opsin RH2-1; opsin-1, medium-wave-sensitive 1; rhodopsin-like-2.1 cone opsin", "tax_id": 7955, "disease": "", "pathway": " (dre:30503)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10349976;12618404;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF109369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC060896.1. On Feb 9, 2004 this sequence version replaced NP_571328.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels (By similarity). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8AYM9", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W6A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6A7-1", "uniprot_id": "OPSR1_DANRE", "mass": 39888.0, "length": 357, "protein_name": "Red-sensitive opsin-1", "gene_name": "opn1lw1", "organism": "Zebrafish", "refseq_name": "red-sensitive opsin-1", "refseq_ac": "NP_001300644", "gene_names_uniprotkb": "opn1lw1; lws1; rdops", "gene_names_refseq": "LWS-1; lws1up; lws1; opn1lw1; rdops; zfred", "protein_names_uniprotkb": "Red-sensitive opsin-1; Opsin LWS-1; Opsin-1, long-wave-sensitive 1; Red cone photoreceptor pigment 1", "protein_names_refseq": "LC opsin; long-wavelength-sensitive-1 cone opsin; red cone photoreceptor pigment 1; red-sensitive opsin-1; red-sensitive opsin", "tax_id": 7955, "disease": "blue cone monochromacy (Disease Ontology:DOID:0050679); red-green color blindness (Disease Ontology:DOID:13909); red color blindness (Disease Ontology:DOID:13910)", "pathway": " (dre:30413); (R-DRE-2187335); (R-DRE-418594); (R-DRE-419771)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10349976;10349978;12618404;8924413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC059415.1, KT008400.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476748, SAMEA4476823 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH444201.1, EH435011.1, EH458584.1 and EH458058.1. On Aug 27, 2015 this sequence version replaced XP_005169308.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to long-wavelength (red) light, thereby decreasing intracellular cAMP levels (PubMed:12618404). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWN3", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009883 red or far-red light photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0009416 response to light stimulus;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W6A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6F9-1", "uniprot_id": "WIF1_DANRE", "mass": 41312.0, "length": 378, "protein_name": "Wnt inhibitory factor 1", "gene_name": "wif1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "wif1; zgc:110507", "gene_names_refseq": "", "protein_names_uniprotkb": "Wnt inhibitory factor 1; WIF-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); invasive ductal carcinoma (Disease Ontology:DOID:3008); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:30476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10201374", "class_list": "", "function": "Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0021986 habenula development;GO:0048794 swim bladder development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W6F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6H5-1", "uniprot_id": "UBC9A_DANRE", "mass": 18053.0, "length": 158, "protein_name": "SUMO-conjugating enzyme UBC9-A", "gene_name": "ube2ia", "organism": "Zebrafish", "refseq_name": "SUMO-conjugating enzyme UBC9-A", "refseq_ac": "NP_571426", "gene_names_uniprotkb": "ube2ia; Ubc9-2; ubc9a; ube2i2; ube2ib; ube2i", "gene_names_refseq": "ubc9; ube2ia; ube2ib; ube2i; zUbc9", "protein_names_uniprotkb": "SUMO-conjugating enzyme UBC9-A; 2.3.2.-; RING-type E3 SUMO transferase UBC9-A; SUMO-protein ligase A; Ubiquitin carrier protein 9-A; Ubiquitin carrier protein I-A; Ubiquitin-conjugating enzyme E2 I-A; Ubiquitin-protein ligase I-A", "protein_names_refseq": "RING-type E3 SUMO transferase UBC9-A; SUMO-conjugating enzyme UBC9-A; SUMO-protein ligase A; ubc9.1; ubiquitin carrier protein 9-A; ubiquitin carrier protein I-A; ubiquitin-conjugating enzyme 9; ubiquitin-conjugating enzyme E2 I-A; ubiquitin-conjugating enzyme E2I; ubiquitin-protein ligase I-A", "tax_id": 7955, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dre:30622); (R-DRE-196791); (R-DRE-3065678); (R-DRE-3108214); (R-DRE-3232118); (R-DRE-3232142); (R-DRE-3899300); (R-DRE-4085377); (R-DRE-4090294); (R-DRE-4551638); (R-DRE-4570464); (R-DRE-4615885); (R-DRE-4655427); (R-DRE-4755510); (R-DRE-5693565); (R-DRE-5693607); (R-DRE-5696395); (R-DRE-8866904); (R-DRE-9615933); (R-DRE-9793242); (R-DRE-9856649); (R-DRE-9937850)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "11331779;17035631", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EL651154.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC059506.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis., [UniProtKB, PubMed, PubMed]; These data indicate an in vivo requirement of Ubc9 for G2/M transition and/or progression through mitosis during vertebrate organogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;5.6.2.2;3.4.13.9;2.7.11.1;2.1.1.354;3.6.4.13;1.14.11.66;2.3.2.27;2.4.2.-;2.4.2.30;2.3.2.-;3.6.4.-;5.6.2.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0019789 SUMO transferase activity;GO:0061656 SUMO conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036306 embryonic heart tube elongation;GO:0031099 regeneration;GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W6H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6S8-1", "uniprot_id": "SMN1_DANRE", "mass": 30986.0, "length": 281, "protein_name": "Survival motor neuron protein 1", "gene_name": "smn1", "organism": "Zebrafish", "refseq_name": "survival motor neuron protein 1", "refseq_ac": "NP_571266", "gene_names_uniprotkb": "smn1; smn", "gene_names_refseq": "fa12d01; smn1; smn; wu:fa12d01", "protein_names_uniprotkb": "Survival motor neuron protein 1", "protein_names_refseq": "survival motor neuron 1; survival motor neuron protein 1", "tax_id": 7955, "disease": "adult spinal muscular atrophy (Disease Ontology:DOID:0050529); intermediate spinal muscular atrophy (Disease Ontology:DOID:0050530); childhood spinal muscular atrophy (Disease Ontology:DOID:0060160); juvenile spinal muscular atrophy (Disease Ontology:DOID:12376); spinal muscular atrophy (Disease Ontology:DOID:12377); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137)", "pathway": " (dre:30432); (R-DRE-191859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10196366;12952942;17065443;18000835;18307296;23063131;29061699", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y17256.1, EH543179.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y17256.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Since Gemin2 and SMN both function in snRNP biogenesis yet only SMN knockdown causes motor axon defects, these data are consistent with an additional role for SMN that is snRNP independent. GeneRIF: Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects., [RefSeq, PubMed]; Survival motor neuron has a novel function in motor neurons independent of small nuclear ribonucleoprotein (snRNP) biosynthesis., [RefSeq, PubMed]; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus (PubMed:23063131). It may also play a role in the metabolism of snoRNPs (PubMed:23063131). Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA (PubMed:23063131). Required for the maturation of motor neuron axonal branches and dendrites (PubMed:23063131, PubMed:29061699)., [UniProtKB, PubMed, PubMed]; These results show that survival motor neuron functions in motor axon development and suggest that these early developmental defects may lead to subsequent motoneuron loss., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043204 perikaryon;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0048936 peripheral nervous system neuron axonogenesis;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0016358 dendrite development;GO:0051124 synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9W6S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W720-1", "uniprot_id": "UCP2_DANRE", "mass": 33573.0, "length": 310, "protein_name": "Dicarboxylate carrier UCP2", "gene_name": "ucp2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ucp2; cb74; slc25a8", "gene_names_refseq": "", "protein_names_uniprotkb": "Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2", "protein_names_refseq": "", "tax_id": 7955, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); carotid artery disease (Disease Ontology:DOID:3407); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-167826)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10524261;11239491;15886331;17971503;18023297;35341844;35617428;35873430;36202338;37406734", "class_list": "", "function": "Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production. May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009409 response to cold;GO:1990845 adaptive thermogenesis;GO:1990542 mitochondrial transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9W720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W7E7-1", "uniprot_id": "SMAD5_DANRE", "mass": 51861.0, "length": 464, "protein_name": "SMAD family member 5", "gene_name": "smad5", "organism": "Zebrafish", "refseq_name": "SMAD family member 5", "refseq_ac": "NP_001333238", "gene_names_uniprotkb": "smad5; madh5; sbn", "gene_names_refseq": "SBN; fb67b04; madh5; mad; pgy; sb:cb400; smad5; smd5; wu:fb67b04", "protein_names_uniprotkb": "SMAD family member 5; MAD homolog 5; Mothers against DPP homolog 5; Mothers against decapentaplegic homolog 5; Protein somitabun; SMAD 5", "protein_names_refseq": "MAD homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; mothers against DPP homolog 5; mothers against decapentaplegic homolog 5; piggytail; somitabun", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787)", "pathway": " (dre:30641); (R-DRE-201451)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10207140;10525190;10590480", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010463.1, BC155776.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505377, SAMEA3505392 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Oct 9, 2016 this sequence version replaced XP_005173222.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W7E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W7J1-1", "uniprot_id": "SE3AA_DANRE", "mass": 97263.0, "length": 860, "protein_name": "Semaphorin-3aa", "gene_name": "sema3aa", "organism": "Zebrafish", "refseq_name": "semaphorin-3aa precursor", "refseq_ac": "NP_571135", "gene_names_uniprotkb": "sema3aa; sema1a; sema3a1; semaZ1a; semaz1a", "gene_names_refseq": "sema1a; sema3a1; sema3aa; semaZ1a", "protein_names_uniprotkb": "Semaphorin-3aa; Sema Z1A; Semaphorin-1A; Semaphorin-Z1A", "protein_names_refseq": "sem1a; sema Z1A; semaphorin 1a; semaphorin-1A; semaphorin-3aa precursor; semaphorin-3aa; semaphorin-Z1A", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 16 with or without anosmia (Disease Ontology:DOID:0090080)", "pathway": " (dre:30266)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10386838;12783793", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF086761.1, BC162398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF086761.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion., [UniProtKB]; Sema3a1 is a guidance factor for neural growth cones and has a role in the development of the vascular system, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0001570 vasculogenesis;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W7J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W7R4-1", "uniprot_id": "TEN3_DANRE", "mass": 300669.0, "length": 2694, "protein_name": "Teneurin-3", "gene_name": "tenm3", "organism": "Zebrafish", "refseq_name": "teneurin-3 isoform X34", "refseq_ac": "XP_073763221", "gene_names_uniprotkb": "tenm3; cb399; id:ibd3379m; id:ibd3379; odz3; srs334; ten-3; ten-m3; tnm3; zgc:153720", "gene_names_refseq": "cb399; id:ibd3379m; id:ibd3379; odz3; srs334; ten-3; ten-m3; tenm3; zgc:153720", "protein_names_uniprotkb": "Teneurin-3; Protein Odd Oz/ten-m homolog 3; Ten-3; Ten-m3; Tenascin-M3; Teneurin transmembrane protein 3", "protein_names_refseq": "teneurin-3 isoform X34", "tax_id": 7955, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:30155)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10495292;11731487;16109975;17521353;18976794;19874812;23594743;24183672;27374343;27951453;28252024;30399559;30914911;33071966", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:24183672, PubMed:27374343). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (By similarity). Required by retinal ganglion cells for acquisition of their correct morphological and functional connectivity, thereby playing a key role in the development of the visual pathway (PubMed:24183672, PubMed:27374343)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "E7EYS1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043005 neuron projection", "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048666 neuron development;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9W7R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YH92-1", "uniprot_id": "CLD7B_DANRE", "mass": 22865.0, "length": 215, "protein_name": "Claudin-7-B", "gene_name": "cldn7b", "organism": "Zebrafish", "refseq_name": "claudin-7-B", "refseq_ac": "NP_571712", "gene_names_uniprotkb": "cldn7b; cldn7", "gene_names_refseq": "cb388; claudin7; cldn7b; cldn7; fd19f08; wu:fd19f08", "protein_names_uniprotkb": "Claudin-7-B; Claudin-like protein ZF4A22", "protein_names_refseq": "claudin-7-B; claudin-7; claudin-like protein ZF4A22", "tax_id": 7955, "disease": "", "pathway": " (dre:60635)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11071763", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ011788.1, BC066408.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a major role in tight junction-specific obliteration of the intercellular space., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0034332 adherens junction organization;GO:0048840 otolith development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YH92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YHT4-1", "uniprot_id": "HEM0_DANRE", "mass": 63909.0, "length": 583, "protein_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "gene_name": "alas2", "organism": "Zebrafish", "refseq_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "refseq_ac": "NP_571757", "gene_names_uniprotkb": "alas2; alas-e", "gene_names_refseq": "alas-e; alas2; cb1063; sauternes; sau; si:dkey-24f17.4", "protein_names_uniprotkb": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 2; ALAS-E; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2", "protein_names_refseq": "5-aminolevulinate synthase 2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; aminolevulinate, delta-, synthetase 2; delta-ALA synthase 2; delta-ALA synthetase; delta-aminolevulinate synthase 2", "tax_id": 7955, "disease": "sideroblastic anemia 1 (Disease Ontology:DOID:0060063); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); hemolytic anemia (Disease Ontology:DOID:583); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (dre:64607); (R-DRE-189451)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9806542", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056338.1, AF095747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056338.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (By similarity). Contributes significantly to heme formation during erythropoiesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXC5", "ec_number_list": "2.3.1.37", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0001666 response to hypoxia;GO:0020027 hemoglobin metabolic process;GO:0030218 erythrocyte differentiation;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YHT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YI66-1", "uniprot_id": "TYRO3_DANRE", "mass": 97599.0, "length": 874, "protein_name": "Tyrosine-protein kinase receptor TYRO3", "gene_name": "tyro3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tyro3; dtk", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor TYRO3; 2.7.10.1; Tyrosine-protein kinase DTK", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9087716", "class_list": "", "function": "May be involved in cell adhesion processes, particularly in the central nervous system., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YI66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WHY6-1", "uniprot_id": "AMR1B_DANRE", "mass": 148984.0, "length": 1360, "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1B", "gene_name": "ambra1b", "organism": "Zebrafish", "refseq_name": "activating molecule in BECN1-regulated autophagy protein 1B", "refseq_ac": "NP_001289149", "gene_names_uniprotkb": "ambra1b", "gene_names_refseq": "ambra1b; im:7146310", "protein_names_uniprotkb": "Activating molecule in BECN1-regulated autophagy protein 1B", "protein_names_refseq": "activating molecule in BECN1-regulated autophagy protein 1B; activating molecule in beclin-1-regulated autophagy", "tax_id": 7955, "disease": "multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (dre:559106); (R-DRE-1632852)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23348054;23594743;24922546;35085890;37106439", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FR846230.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FR846230.2. On Oct 7, 2014 this sequence version replaced XP_009296059.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle. Erratum:[PLoS One. 2014;9(9):e109480] Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:23348054). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins (By similarity). Acts as an upstream master regulator of the transition from G1 to S cell phase: ambra1b specifically recognizes and binds phosphorylated cyclin-D (ccnd1, ccnd2 and ccnd3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (By similarity). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (eloc) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (By similarity). In normal conditions, ambra1b is tethered to the cytoskeleton via interaction with dyneins light chains (By similarity). Upon autophagy induction, ambra1b is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). Also acts as an activator of mitophagy (By similarity). Required for skeletal muscle development (PubMed:24922546)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; The role of ambra1 in Pb-induced developmental neurotoxicity in zebrafish., [RefSeq, PubMed]; Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "I3IRN1", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0000045 autophagosome assembly;GO:0007626 locomotory behavior;GO:0048741 skeletal muscle fiber development;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "X1WHY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AUL1-1", "uniprot_id": "A0A8M3AUL1_DANRE", "mass": 159234.0, "length": 1450, "protein_name": "Neogenin", "gene_name": "neo1a", "organism": "Zebrafish", "refseq_name": "neogenin 1a isoform X1", "refseq_ac": "XP_009301739", "gene_names_uniprotkb": "neo1a; cb333; neo1; zgc:109795; zneo1", "gene_names_refseq": "cb333; neo1a; neo1; zgc:109795; zneo1", "protein_names_uniprotkb": "Neogenin", "protein_names_refseq": "neogenin 1a isoform X1", "tax_id": 7955, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:266983)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12351191;15081375;15087125;15973704;17937501;30174136;31399534;32678143;35110541;35940453", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0000902 cell morphogenesis;GO:0001756 somitogenesis;GO:0001841 neural tube formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AUL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AL82-1", "uniprot_id": "A0A8M3AL82_DANRE", "mass": 63827.0, "length": 570, "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "mapk15", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mapk15; erk7; zgc:110345", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 15; 2.7.11.24", "protein_names_refseq": "", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:553780)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16774848;27189481", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3AL82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AXA7-1", "uniprot_id": "A0A8M3AXA7_DANRE", "mass": 72770.0, "length": 640, "protein_name": "Cryptochrome circadian regulator 3b isoform X1", "gene_name": "cry3b", "organism": "Zebrafish", "refseq_name": "cryptochrome circadian regulator 3b isoform X1", "refseq_ac": "XP_009294043", "gene_names_uniprotkb": "cry3b; cry1bb; cry2b; zcry2b", "gene_names_refseq": "cry1bb; cry2b; cry3b; zcry2b", "protein_names_uniprotkb": "Cryptochrome circadian regulator 3b isoform X1", "protein_names_refseq": "cryptochrome circadian regulator 3b isoform X1", "tax_id": 7955, "disease": "delayed sleep phase syndrome (Disease Ontology:DOID:0111141)", "pathway": " (dre:83780)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10971654;12354100;20804179;20830285;22031781;32168317;32193419;34769181;34925060;35672786", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009294043.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0071949 FAD binding;GO:0009881 photoreceptor activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0032922 circadian regulation of gene expression;GO:0043153 entrainment of circadian clock by photoperiod;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AXA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWF2-1", "uniprot_id": "A0A8M3AWF2_DANRE", "mass": 107088.0, "length": 933, "protein_name": "Aminopeptidase", "gene_name": "erap1a", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum aminopeptidase 1 isoform X1", "refseq_ac": "XP_692516", "gene_names_uniprotkb": "erap1a", "gene_names_refseq": "erap1a", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "endoplasmic reticulum aminopeptidase 1 isoform X1", "tax_id": 7955, "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893)", "pathway": " (dre:564068); (R-DRE-983170)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_692516.2. COMPLETENESS: full length., [RefSeq]; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QIR0;F1QT33", "ec_number_list": "3.4.11.-", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0006508 proteolysis;GO:0002250 adaptive immune response;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AWF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AY68-1", "uniprot_id": "A0A8M3AY68_DANRE", "mass": 285429.0, "length": 2567, "protein_name": "Jumonji domain-containing protein 1C", "gene_name": "jmjd1cb", "organism": "Zebrafish", "refseq_name": "probable JmjC domain-containing histone demethylation protein 2C isoform X1", "refseq_ac": "XP_009304785", "gene_names_uniprotkb": "jmjd1cb", "gene_names_refseq": "jmjd1cb", "protein_names_uniprotkb": "Jumonji domain-containing protein 1C", "protein_names_refseq": "probable JmjC domain-containing histone demethylation protein 2C isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:558436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304785.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051213 dioxygenase activity;GO:0032454 histone H3K9 demethylase activity;GO:0031490 chromatin DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030097 hemopoiesis;GO:0061515 myeloid cell development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ATP1-1", "uniprot_id": "A0A8M3ATP1_DANRE", "mass": 55892.0, "length": 496, "protein_name": "Fli-1 proto-oncogene, ETS transcription factor-related sequence isoform X1", "gene_name": "fli1rs", "organism": "Zebrafish", "refseq_name": "fli-1 proto-oncogene, ETS transcription factor-related sequence isoform X1", "refseq_ac": "XP_009290803", "gene_names_uniprotkb": "fli1rs; fli1b; zgc:5777174", "gene_names_refseq": "fli1b; fli1rs; zgc:5777174", "protein_names_uniprotkb": "Fli-1 proto-oncogene, ETS transcription factor-related sequence isoform X1", "protein_names_refseq": "fli-1 proto-oncogene, ETS transcription factor-related sequence isoform X1", "tax_id": 7955, "disease": "limb ischemia (Disease Ontology:DOID:0050852); thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B3H9-1", "uniprot_id": "A0A8M3B3H9_DANRE", "mass": 70718.0, "length": 636, "protein_name": "Nephronectin a isoform X1", "gene_name": "npnta", "organism": "Zebrafish", "refseq_name": "nephronectin a isoform X1", "refseq_ac": "XP_009292491", "gene_names_uniprotkb": "npnta; POEM; npnt; si:ch211-202n8.2", "gene_names_refseq": "POEM; npnta; npnt; si:ch211-202n8.2", "protein_names_uniprotkb": "Nephronectin a isoform X1", "protein_names_refseq": "nephronectin a isoform X1", "tax_id": 7955, "disease": "bilateral renal aplasia (Disease Ontology:DOID:0080200); membranous glomerulonephritis (Disease Ontology:DOID:10976); proteinuria (Disease Ontology:DOID:576)", "pathway": " (dre:563273)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21937601;23458150;26469318;27189481;27265864;28476557;33234717;34716242", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0007155 cell adhesion;GO:0030855 epithelial cell differentiation;GO:0060347 heart trabecula formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M3B3H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AL25-1", "uniprot_id": "A0A8M3AL25_DANRE", "mass": 92944.0, "length": 834, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark3b", "organism": "Zebrafish", "refseq_name": "MAP/microtubule affinity-regulating kinase 3 isoform X1", "refseq_ac": "XP_009293196", "gene_names_uniprotkb": "mark3b; si:dkeyp-50f7.6; zgc:153725", "gene_names_refseq": "mark3b; si:dkeyp-50f7.6; zgc:153725", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 3 isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:767634)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;24467753;26469318;28252024;34329618", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3AL25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APQ1-1", "uniprot_id": "A0A8M3APQ1_DANRE", "mass": 203796.0, "length": 1799, "protein_name": "plus-end-directed kinesin ATPase", "gene_name": "kif1ab", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF1A isoform X1", "refseq_ac": "XP_009296795", "gene_names_uniprotkb": "kif1ab", "gene_names_refseq": "kif1ab", "protein_names_uniprotkb": "plus-end-directed kinesin ATPase; 5.6.1.3", "protein_names_refseq": "kinesin-like protein KIF1A isoform X1", "tax_id": 7955, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); synucleinopathy (Disease Ontology:DOID:0050890); NESCAV syndrome (Disease Ontology:DOID:0070039); hereditary sensory neuropathy type 2C (Disease Ontology:DOID:0070147); hereditary spastic paraplegia 30B (Disease Ontology:DOID:0070646); hereditary spastic paraplegia 30A (Disease Ontology:DOID:0070647); Graves ophthalmopathy (Disease Ontology:DOID:0081120); hereditary spastic paraplegia 30 (Disease Ontology:DOID:0110781); hereditary spastic paraplegia (Disease Ontology:DOID:2476); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (dre:566766)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008574 plus-end-directed microtubule motor activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005874 microtubule;GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0048731 system development;GO:0010970 transport along microtubule;GO:0016192 vesicle-mediated transport;GO:1990049 retrograde neuronal dense core vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APP4-1", "uniprot_id": "A0A8M3APP4_DANRE", "mass": 134956.0, "length": 1315, "protein_name": "Collagen, type XV, alpha 1b isoform X1", "gene_name": "col15a1b", "organism": "Zebrafish", "refseq_name": "collagen, type XV, alpha 1b isoform X1", "refseq_ac": "XP_009296788", "gene_names_uniprotkb": "col15a1b; cb491; sb:cb491; si:dkeyp-93c5.1; wu:fb50f05; wu:fc22d09", "gene_names_refseq": "cb491; col15a1b; sb:cb491; si:dkeyp-93c5.1; wu:fb50f05; wu:fc22d09", "protein_names_uniprotkb": "Collagen, type XV, alpha 1b isoform X1", "protein_names_refseq": "collagen, type XV, alpha 1b isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0008045 motor neuron axon guidance;GO:0001654 eye development;GO:1905812 regulation of motor neuron axon guidance;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B137-1", "uniprot_id": "A0A8M3B137_DANRE", "mass": 238413.0, "length": 2101, "protein_name": "Chromodomain-helicase-DNA-binding protein 3 isoform X1", "gene_name": "chd3", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 3 isoform X1", "refseq_ac": "XP_009301392", "gene_names_uniprotkb": "chd3", "gene_names_refseq": "chd3", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 3 isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 3 isoform X1", "tax_id": 7955, "disease": "pancreatic carcinoma (Disease Ontology:DOID:4905)", "pathway": " (dre:568230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031981 nuclear lumen;GO:0032991 protein-containing complex;GO:0000785 chromatin;GO:0016581 NuRD complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007417 central nervous system development;GO:0035176 social behavior;GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B1F5-1", "uniprot_id": "A0A8M3B1F5_DANRE", "mass": 103976.0, "length": 935, "protein_name": "Trafficking kinesin-binding protein 1 isoform X1", "gene_name": "trak1a", "organism": "Zebrafish", "refseq_name": "trafficking kinesin-binding protein 1 isoform X1", "refseq_ac": "XP_009290320", "gene_names_uniprotkb": "trak1a", "gene_names_refseq": "trak1a", "protein_names_uniprotkb": "Trafficking kinesin-binding protein 1 isoform X1", "protein_names_refseq": "trafficking kinesin-binding protein 1 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); neurodegenerative disease (Disease Ontology:DOID:1289); Stiff-Person syndrome (Disease Ontology:DOID:13366)", "pathway": " (dre:100002689)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290320.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017022 myosin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006605 protein targeting;GO:0008333 endosome to lysosome transport;GO:0022008 neurogenesis;GO:0048311 mitochondrion distribution;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B1F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AS61-1", "uniprot_id": "A0A8M3AS61_DANRE", "mass": 73084.0, "length": 646, "protein_name": "Beta-galactosidase", "gene_name": "si:dkey-224e22.2", "organism": "Zebrafish", "refseq_name": "beta-galactosidase-1-like protein 2 isoform X1", "refseq_ac": "XP_009292108", "gene_names_uniprotkb": "si:dkey-224e22.2", "gene_names_refseq": "si:dkey-224e22.2", "protein_names_uniprotkb": "Beta-galactosidase; 3.2.1.23", "protein_names_refseq": "beta-galactosidase-1-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:799022)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009292108.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0097546 ciliary base;GO:0005773 vacuole", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0060271 cilium assembly;GO:0044782 cilium organization;GO:0019388 galactose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AS61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B435-1", "uniprot_id": "A0A8M3B435_DANRE", "mass": 156898.0, "length": 1413, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "nek1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Nek1 isoform X1", "refseq_ac": "XP_009292952", "gene_names_uniprotkb": "nek1", "gene_names_refseq": "nek1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase Nek1 isoform X1", "tax_id": 7955, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); orofaciodigital syndrome II (Disease Ontology:DOID:0060959); amyotrophic lateral sclerosis type 24 (Disease Ontology:DOID:0081378); short-rib thoracic dysplasia 6 with or without polydactyly (Disease Ontology:DOID:0110092); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (dre:556002)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004672 protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ALN1-1", "uniprot_id": "A0A8M3ALN1_DANRE", "mass": 550558.0, "length": 4863, "protein_name": "Ryanodine receptor 3 isoform X1", "gene_name": "ryr3", "organism": "Zebrafish", "refseq_name": "ryanodine receptor 3 isoform X1", "refseq_ac": "XP_009293048", "gene_names_uniprotkb": "ryr3", "gene_names_refseq": "ryr3", "protein_names_uniprotkb": "Ryanodine receptor 3 isoform X1", "protein_names_refseq": "ryanodine receptor 3 isoform X1", "tax_id": 7955, "disease": "congenital myopathy 20 (Disease Ontology:DOID:0081352); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); congenital myopathy 1A (Disease Ontology:DOID:3529); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (dre:561350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009293048.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005509 calcium ion binding;GO:0005219 ryanodine-sensitive calcium-release channel activity", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006874 intracellular calcium ion homeostasis;GO:0048741 skeletal muscle fiber development;GO:0007224 smoothened signaling pathway;GO:0021532 neural tube patterning", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ALN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AM79-1", "uniprot_id": "A0A8M3AM79_DANRE", "mass": 62686.0, "length": 570, "protein_name": "Nuclear factor 1", "gene_name": "nfia", "organism": "Zebrafish", "refseq_name": "nuclear factor 1 A-type isoform X1", "refseq_ac": "XP_009294512", "gene_names_uniprotkb": "nfia; si:ch211-88d2.2; wu:fq27e07; zgc:158351", "gene_names_refseq": "nfia; si:ch211-88d2.2; wu:fq27e07; zgc:158351", "protein_names_uniprotkb": "Nuclear factor 1", "protein_names_refseq": "nuclear factor 1 A-type isoform X1", "tax_id": 7955, "disease": "NFIA-related disorder (Disease Ontology:DOID:0060409)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AM79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AM99-1", "uniprot_id": "A0A8M3AM99_DANRE", "mass": 141775.0, "length": 1262, "protein_name": "AP-3 complex subunit delta-1", "gene_name": "ap3d1", "organism": "Zebrafish", "refseq_name": "AP-3 complex subunit delta-1 isoform X1", "refseq_ac": "XP_009294540", "gene_names_uniprotkb": "ap3d1; si:ch211-129c21.6; wu:fj51g01", "gene_names_refseq": "ap3d1; si:ch211-129c21.6; wu:fj51g01", "protein_names_uniprotkb": "AP-3 complex subunit delta-1; AP-3 complex subunit delta; Adaptor-related protein complex 3 subunit delta-1; Delta-adaptin", "protein_names_refseq": "AP-3 complex subunit delta-1 isoform X1", "tax_id": 7955, "disease": "Hermansky-Pudlak syndrome 1 (Disease Ontology:DOID:0060539); Hermansky-Pudlak syndrome 2 (Disease Ontology:DOID:0060540); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0030659 cytoplasmic vesicle membrane;GO:0030123 AP-3 adaptor complex", "go_biological_process": "GO:0045634 regulation of melanocyte differentiation;GO:0006886 intracellular protein transport;GO:0010507 negative regulation of autophagy;GO:0016192 vesicle-mediated transport;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AM99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANQ1-1", "uniprot_id": "A0A8M3ANQ1_DANRE", "mass": 60931.0, "length": 538, "protein_name": "Carbonic anhydrase", "gene_name": "ca6", "organism": "Zebrafish", "refseq_name": "carbonic anhydrase 6 isoform X1", "refseq_ac": "XP_009295179", "gene_names_uniprotkb": "ca6", "gene_names_refseq": "ca6", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100006448); (R-DRE-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Reversible hydration of carbon dioxide. Its role in saliva is unknown., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F742", "ec_number_list": "4.2.1.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWA7-1", "uniprot_id": "A0A8M3AWA7_DANRE", "mass": 114002.0, "length": 1037, "protein_name": "Myelin regulatory factor", "gene_name": "myrf", "organism": "Zebrafish", "refseq_name": "myelin regulatory factor isoform X1", "refseq_ac": "XP_009295998", "gene_names_uniprotkb": "myrf", "gene_names_refseq": "myrf", "protein_names_uniprotkb": "Myelin regulatory factor; Myelin gene regulatory factor", "protein_names_refseq": "myelin regulatory factor isoform X1", "tax_id": 7955, "disease": "nanophthalmos (Disease Ontology:DOID:0080634); primary angle-closure glaucoma (Disease Ontology:DOID:1405); cerebral infarction (Disease Ontology:DOID:3526); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); eye disease (Disease Ontology:DOID:5614); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (dre:570792)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008233 peptidase activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0022010 central nervous system myelination;GO:0016540 protein autoprocessing;GO:0014003 oligodendrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AP68-1", "uniprot_id": "A0A8M3AP68_DANRE", "mass": 83175.0, "length": 739, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6ka3b", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-3 isoform X1", "refseq_ac": "XP_009295647", "gene_names_uniprotkb": "rps6ka3b; zgc:158386", "gene_names_refseq": "rps6ka3b; zgc:158386", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-3 isoform X1", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 19 (Disease Ontology:DOID:0112019); intellectual disability (Disease Ontology:DOID:1059); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (dre:100009657)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19500364;24240475;27189481;28252024;30032135;35571926", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0001503 ossification;GO:0038202 TORC1 signaling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AP68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APA4-1", "uniprot_id": "A0A8M3APA4_DANRE", "mass": 121014.0, "length": 1082, "protein_name": "Activated CDC42 kinase 1", "gene_name": "tnk2a", "organism": "Zebrafish", "refseq_name": "activated CDC42 kinase 1 isoform X1", "refseq_ac": "XP_009295758", "gene_names_uniprotkb": "tnk2a", "gene_names_refseq": "tnk2a", "protein_names_uniprotkb": "Activated CDC42 kinase 1; 2.7.10.2; 2.7.11.1; Tyrosine kinase non-receptor protein 2", "protein_names_refseq": "activated CDC42 kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148041)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009295758.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APY5-1", "uniprot_id": "A0A8M3APY5_DANRE", "mass": 79619.0, "length": 707, "protein_name": "Phosphodiesterase", "gene_name": "pde4bb", "organism": "Zebrafish", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4B isoform X1", "refseq_ac": "XP_009296519", "gene_names_uniprotkb": "pde4bb", "gene_names_refseq": "pde4bb", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4B isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:555599)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.53", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQK6-1", "uniprot_id": "A0A8M3AQK6_DANRE", "mass": 75868.0, "length": 686, "protein_name": "Nuclear receptor subfamily 4 group A member 2", "gene_name": "nr4a3", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 4 group A member 3 isoform X1", "refseq_ac": "XP_009290607", "gene_names_uniprotkb": "nr4a3; NOR1", "gene_names_refseq": "NOR1; nr4a3", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 2", "protein_names_refseq": "nuclear receptor subfamily 4 group A member 3 isoform X1", "tax_id": 7955, "disease": "extraskeletal myxoid chondrosarcoma (Disease Ontology:DOID:4549)", "pathway": " (dre:548604)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17997606;18822380;25556858;25711679;26024593;27189481;27356472;28637666;29794036;35524578", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001780 neutrophil homeostasis;GO:0071376 cellular response to corticotropin-releasing hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AQK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQN2-1", "uniprot_id": "A0A8M3AQN2_DANRE", "mass": 121540.0, "length": 1070, "protein_name": "Guanylate cyclase", "gene_name": "npr1b", "organism": "Zebrafish", "refseq_name": "atrial natriuretic peptide receptor 1", "refseq_ac": "XP_009290669", "gene_names_uniprotkb": "npr1b", "gene_names_refseq": "npr1b", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "atrial natriuretic peptide receptor 1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:555911)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009290669.1. COMPLETENESS: full length., [RefSeq]; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth., [UniProtKB, UniProtKB]; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0097746 blood vessel diameter maintenance;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AQN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AY36-1", "uniprot_id": "A0A8M3AY36_DANRE", "mass": 95101.0, "length": 862, "protein_name": "Serine/threonine-protein kinase BRSK1 isoform X1", "gene_name": "brsk1b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase BRSK1 isoform X1", "refseq_ac": "XP_009297839", "gene_names_uniprotkb": "brsk1b", "gene_names_refseq": "brsk1b", "protein_names_uniprotkb": "Serine/threonine-protein kinase BRSK1 isoform X1", "protein_names_refseq": "serine/threonine-protein kinase BRSK1 isoform X1", "tax_id": 7955, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dre:558390)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.26;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0050321 tau-protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AY41-1", "uniprot_id": "A0A8M3AY41_DANRE", "mass": 82612.0, "length": 728, "protein_name": "Synembryn", "gene_name": "si:ch211-195b15.7", "organism": "Zebrafish", "refseq_name": "chaperone Ric-8A isoform X1", "refseq_ac": "XP_009297845", "gene_names_uniprotkb": "si:ch211-195b15.7", "gene_names_refseq": "si:ch211-195b15.7", "protein_names_uniprotkb": "Synembryn; Protein Ric-8", "protein_names_refseq": "chaperone Ric-8A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557783)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQT9-1", "uniprot_id": "A0A8M3AQT9_DANRE", "mass": 129903.0, "length": 1141, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "taok2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase TAO2 isoform X1", "refseq_ac": "XP_009297645", "gene_names_uniprotkb": "taok2a", "gene_names_refseq": "taok2a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase TAO2 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dre:556172)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0007420 brain development;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AQT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQZ8-1", "uniprot_id": "A0A8M3AQZ8_DANRE", "mass": 99421.0, "length": 874, "protein_name": "Xylosyltransferase 2", "gene_name": "xylt2", "organism": "Zebrafish", "refseq_name": "xylosyltransferase 2 isoform X1", "refseq_ac": "XP_009298134", "gene_names_uniprotkb": "xylt2; zgc:194562", "gene_names_refseq": "xylt2; zgc:194562", "protein_names_uniprotkb": "Xylosyltransferase 2; 2.4.2.26; Xylosyltransferase II", "protein_names_refseq": "xylosyltransferase 2 isoform X1", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pseudoxanthoma elasticum (Disease Ontology:DOID:2738)", "pathway": " (dre:563446)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26876635;27189481;33363150", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.26", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030158 protein xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AQZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AR02-1", "uniprot_id": "A0A8M3AR02_DANRE", "mass": 30128.0, "length": 261, "protein_name": "Protein unc-119 homolog B-B isoform X8", "gene_name": "unc119c", "organism": "Zebrafish", "refseq_name": "unc-119 lipid binding chaperone c", "refseq_ac": "NP_001427817", "gene_names_uniprotkb": "unc119c; mmp25a", "gene_names_refseq": "si:ch73-248e21.4; unc119.2; unc119c; wu:fk57d06; zfUnc119c", "protein_names_uniprotkb": "Protein unc-119 homolog B-B isoform X8", "protein_names_refseq": "unc-119 homolog 2; unc-119 lipid binding chaperone B homolog 2; unc-119 lipid binding chaperone c", "tax_id": 7955, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572)", "pathway": " (dre:100001739)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23749482", "class_list": "", "function": "Unc119c, together with Arl3l1/2, plays an important role in modulating Wnt4a production and secretion during HC formation in the forebrain of the zebrafish embryo., [RefSeq, PubMed]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J2I2", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0015031 protein transport;GO:0048841 regulation of axon extension involved in axon guidance;GO:0071632 optomotor response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M3AR02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AR84-1", "uniprot_id": "A0A8M3AR84_DANRE", "mass": 78049.0, "length": 681, "protein_name": "Protein kinase C", "gene_name": "prkcab", "organism": "Zebrafish", "refseq_name": "protein kinase C alpha type isoform X1", "refseq_ac": "XP_009298084", "gene_names_uniprotkb": "prkcab", "gene_names_refseq": "prkcab", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C alpha type isoform X1", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); chordoid glioma (Disease Ontology:DOID:3774); ovarian carcinoma (Disease Ontology:DOID:4001); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:100333967)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AR84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B1K8-1", "uniprot_id": "A0A8M3B1K8_DANRE", "mass": 130733.0, "length": 1180, "protein_name": "Neural cell adhesion molecule L1", "gene_name": "nrcama", "organism": "Zebrafish", "refseq_name": "neuronal cell adhesion molecule a isoform 4 precursor", "refseq_ac": "NP_001429925", "gene_names_uniprotkb": "nrcama; nrcam; si:dkey-240a12.1", "gene_names_refseq": "nrcama; nrcam; si:dkey-240a12.1", "protein_names_uniprotkb": "Neural cell adhesion molecule L1", "protein_names_refseq": "neuronal cell adhesion molecule a isoform 4 precursor", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); MASA syndrome (Disease Ontology:DOID:0060246); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:556537)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24180662;26469318;27189481;28252024;28465218;32902807;35108495", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.920074.1, SRR32588730.4511548.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476752 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Sep 3, 2025 this sequence version replaced XP_009298414.1., [RefSeq]; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030426 growth cone;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0061564 axon development;GO:0036269 swimming behavior;GO:0098609 cell-cell adhesion;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M3B1K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ARE4-1", "uniprot_id": "A0A8M3ARE4_DANRE", "mass": 107541.0, "length": 968, "protein_name": "Diacylglycerol kinase", "gene_name": "dgki", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase iota isoform X1", "refseq_ac": "XP_009298312", "gene_names_uniprotkb": "dgki", "gene_names_refseq": "dgki", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase iota isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ARE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ARX1-1", "uniprot_id": "A0A8M3ARX1_DANRE", "mass": 176908.0, "length": 1558, "protein_name": "Chromatin-remodeling ATPase INO80", "gene_name": "ino80", "organism": "Zebrafish", "refseq_name": "chromatin-remodeling ATPase INO80 isoform X1", "refseq_ac": "XP_009299103", "gene_names_uniprotkb": "ino80; si:ch211-244p18.3", "gene_names_refseq": "ino80; si:ch211-244p18.3", "protein_names_uniprotkb": "Chromatin-remodeling ATPase INO80; 3.6.4.-", "protein_names_refseq": "chromatin-remodeling ATPase INO80 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566768)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24240475;26469318;32196499;32756943;34390914", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0031011 Ino80 complex", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3ARX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B2S1-1", "uniprot_id": "A0A8M3B2S1_DANRE", "mass": 52263.0, "length": 483, "protein_name": "Myocyte enhancer factor 2cb isoform X1", "gene_name": "mef2cb", "organism": "Zebrafish", "refseq_name": "myocyte enhancer factor 2cb isoform X1", "refseq_ac": "XP_009300032", "gene_names_uniprotkb": "mef2cb; si:ch211-202e12.2", "gene_names_refseq": "mef2cb; si:ch211-202e12.2", "protein_names_uniprotkb": "Myocyte enhancer factor 2cb isoform X1", "protein_names_refseq": "myocyte enhancer factor 2cb isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4ITE5", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003143 embryonic heart tube morphogenesis;GO:0055007 cardiac muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B2S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ASP8-1", "uniprot_id": "A0A8M3ASP8_DANRE", "mass": 92070.0, "length": 796, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "ppef2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase with EF-hands 2 isoform X1", "refseq_ac": "XP_009300090", "gene_names_uniprotkb": "ppef2a", "gene_names_refseq": "ppef2a", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "serine/threonine-protein phosphatase with EF-hands 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100537120)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300090.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0005506 iron ion binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0050906 detection of stimulus involved in sensory perception;GO:0043409 negative regulation of MAPK cascade;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ASP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AT49-1", "uniprot_id": "A0A8M3AT49_DANRE", "mass": 108673.0, "length": 978, "protein_name": "Protein PTHB1 isoform X1", "gene_name": "bbs9", "organism": "Zebrafish", "refseq_name": "protein PTHB1 isoform X1", "refseq_ac": "XP_009290332", "gene_names_uniprotkb": "bbs9", "gene_names_refseq": "bbs9", "protein_names_uniprotkb": "Protein PTHB1 isoform X1", "protein_names_refseq": "protein PTHB1 isoform X1", "tax_id": 7955, "disease": "Bardet-Biedl syndrome 9 (Disease Ontology:DOID:0110131); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); craniosynostosis (Disease Ontology:DOID:2340); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dre:100333716)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290332.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0034464 BBSome", "go_biological_process": "GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0010842 retina layer formation;GO:0007369 gastrulation;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AT49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ATF0-1", "uniprot_id": "A0A8M3ATF0_DANRE", "mass": 37121.0, "length": 337, "protein_name": "Cathepsin S, ortholog 2, tandem duplicate 2 isoform X1", "gene_name": "ctss2.2", "organism": "Zebrafish", "refseq_name": "cathepsin S, ortholog 2, tandem duplicate 2 isoform X1", "refseq_ac": "XP_009290599", "gene_names_uniprotkb": "ctss2.2; ctssb.2; ctssb2; wu:fj84d06; zgc:111950; zgc:112489", "gene_names_refseq": "ctss2.2; ctssb.2; ctssb2; wu:fj84d06; zgc:111950; zgc:112489", "protein_names_uniprotkb": "Cathepsin S, ortholog 2, tandem duplicate 2 isoform X1", "protein_names_refseq": "cathepsin S, ortholog 2, tandem duplicate 2 isoform X1", "tax_id": 7955, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); COVID-19 (Disease Ontology:DOID:0080600); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); sarcoidosis (Disease Ontology:DOID:11335); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); carotid artery disease (Disease Ontology:DOID:3407); neuropathy (Disease Ontology:DOID:870); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWN1-1", "uniprot_id": "A0A8M3AWN1_DANRE", "mass": 98453.0, "length": 874, "protein_name": "Phosphodiesterase", "gene_name": "pde8b", "organism": "Zebrafish", "refseq_name": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1", "refseq_ac": "XP_009293455", "gene_names_uniprotkb": "pde8b", "gene_names_refseq": "pde8b", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1", "tax_id": 7955, "disease": "primary pigmented nodular adrenocortical disease 3 (Disease Ontology:DOID:0070548)", "pathway": " (dre:571011)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006355 regulation of DNA-templated transcription;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0006198 cAMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ATS4-1", "uniprot_id": "A0A8M3ATS4_DANRE", "mass": 54728.0, "length": 475, "protein_name": "Hyaluronidase", "gene_name": "hyal2a", "organism": "Zebrafish", "refseq_name": "hyaluronidase-2 isoform X2", "refseq_ac": "XP_009301004", "gene_names_uniprotkb": "hyal2a", "gene_names_refseq": "hyal2a", "protein_names_uniprotkb": "Hyaluronidase; 3.2.1.35", "protein_names_refseq": "hyaluronidase-2 isoform X2", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:567869); (R-DRE-2142845); (R-DRE-2160916)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E7F701", "ec_number_list": "3.2.1.35", "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0033906 hyaluronoglucuronidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ATS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ATV7-1", "uniprot_id": "A0A8M3ATV7_DANRE", "mass": 78544.0, "length": 711, "protein_name": "Sulfate transporter", "gene_name": "slc26a1", "organism": "Zebrafish", "refseq_name": "sulfate anion transporter 1", "refseq_ac": "NP_001074136", "gene_names_uniprotkb": "slc26a1; sb:cb565; wu:fe23c03; zgc:158435", "gene_names_refseq": "sb:cb565; slc26a1; wu:fe23c03; zgc:158435", "protein_names_uniprotkb": "Sulfate transporter; Solute carrier family 26 member 2", "protein_names_refseq": "Sat1; solute carrier family 26 (anion exchanger), member 1; solute carrier family 26 (sulfate transporter), member 1; sulfate anion transporter 1", "tax_id": 7955, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652)", "pathway": " (dre:791185); (R-DRE-174362); (R-DRE-427601)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "16574097;18816841;19801433;20423468;22421047;28878000;29180571;29344929;31188030;33749326", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01038432.1, GDQH01001460.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476740, SAMEA4476744 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Jun 25, 2025 this sequence version replaced NP_001074136.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IDN4", "ec_number_list": "", "go_molecular_function": "GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3ATV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AU21-1", "uniprot_id": "A0A8M3AU21_DANRE", "mass": 93429.0, "length": 828, "protein_name": "Neuroligin-2a isoform X1", "gene_name": "nlgn2a", "organism": "Zebrafish", "refseq_name": "neuroligin-2a isoform X1", "refseq_ac": "XP_009301340", "gene_names_uniprotkb": "nlgn2a", "gene_names_refseq": "nlgn2a", "protein_names_uniprotkb": "Neuroligin-2a isoform X1", "protein_names_refseq": "neuroligin-2a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (R-DRE-6794361)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58FZ96;F1QJV3", "ec_number_list": "", "go_molecular_function": "GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0099634 postsynaptic specialization membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AU21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AU43-1", "uniprot_id": "A0A8M3AU43_DANRE", "mass": 31840.0, "length": 288, "protein_name": "Delta-sarcoglycan isoform X4", "gene_name": "sgcd", "organism": "Zebrafish", "refseq_name": "delta-sarcoglycan isoform X4", "refseq_ac": "XP_009293869", "gene_names_uniprotkb": "sgcd; wu:fc49e11; zgc:110649", "gene_names_refseq": "sgcd; wu:fc49e11; zgc:110649", "protein_names_uniprotkb": "Delta-sarcoglycan isoform X4", "protein_names_refseq": "delta-sarcoglycan isoform X4", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2F (Disease Ontology:DOID:0110280); dilated cardiomyopathy 1L (Disease Ontology:DOID:0110436); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:324961); (R-DRE-9913351)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12659844;15520368;15707578;16109975;16650823;27189481;28437249;28871129;29593015;37628888", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0042383 sarcolemma;GO:0016012 sarcoglycan complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0048742 regulation of skeletal muscle fiber development;GO:0060047 heart contraction;GO:0048738 cardiac muscle tissue development;GO:0014732 skeletal muscle atrophy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AU43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AU53-1", "uniprot_id": "A0A8M3AU53_DANRE", "mass": 219380.0, "length": 1996, "protein_name": "[histone H3]-trimethyl-L-lysine(27) demethylase", "gene_name": "kdm6ba", "organism": "Zebrafish", "refseq_name": "lysine-specific demethylase 6B", "refseq_ac": "XP_005172296", "gene_names_uniprotkb": "kdm6ba", "gene_names_refseq": "kdm6ba", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(27) demethylase; 1.14.11.68", "protein_names_refseq": "lysine-specific demethylase 6B", "tax_id": 7955, "disease": "Stolerman neurodevelopmental syndrome (Disease Ontology:DOID:0081443); alcohol use disorder (Disease Ontology:DOID:1574); breast carcinoma (Disease Ontology:DOID:3459); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:556678); (R-DRE-2559580); (R-DRE-3214842)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NSI1;A0AC58G3Y2;A0AC58G3Y9;A0AC58G3Z1;A0AC58G3Z3;A0AC58G3Z7;A0AC58G409;A0AC58G418", "ec_number_list": "1.14.11.68;1.14.11.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0071558 histone H3K27me2/H3K27me3 demethylase activity", "go_cellular_component": "GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0007507 heart development;GO:0010468 regulation of gene expression;GO:0061384 heart trabecula morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AU53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AUB3-1", "uniprot_id": "A0A8M3AUB3_DANRE", "mass": 31139.0, "length": 274, "protein_name": "F-actin-capping protein subunit beta", "gene_name": "capzb", "organism": "Zebrafish", "refseq_name": "F-actin-capping protein subunit beta isoform X1", "refseq_ac": "XP_009294020", "gene_names_uniprotkb": "capzb; wu:fk65f06; zgc:66149", "gene_names_refseq": "capzb; wu:fk65f06; zgc:66149", "protein_names_uniprotkb": "F-actin-capping protein subunit beta", "protein_names_refseq": "F-actin-capping protein subunit beta isoform X1", "tax_id": 7955, "disease": "dementia (Disease Ontology:DOID:1307); cleft palate (Disease Ontology:DOID:674)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008290 F-actin capping protein complex", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0001755 neural crest cell migration;GO:0014033 neural crest cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AUB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AV10-1", "uniprot_id": "A0A8M3AV10_DANRE", "mass": 81959.0, "length": 734, "protein_name": "Protein-glutamine gamma-glutamyltransferase K", "gene_name": "tgm1", "organism": "Zebrafish", "refseq_name": "protein-glutamine gamma-glutamyltransferase K isoform X1", "refseq_ac": "XP_009294851", "gene_names_uniprotkb": "tgm1", "gene_names_refseq": "tgm1", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase K; 2.3.2.13; Epidermal TGase; Transglutaminase K; Transglutaminase-1", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase K isoform X1", "tax_id": 7955, "disease": "autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656)", "pathway": " (dre:100334173)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.13;3.5.1.44", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AV10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AVD9-1", "uniprot_id": "A0A8M3AVD9_DANRE", "mass": 40570.0, "length": 364, "protein_name": "PDZ and LIM domain protein 2", "gene_name": "pdlim2", "organism": "Zebrafish", "refseq_name": "PDZ and LIM domain protein 2", "refseq_ac": "NP_001313331", "gene_names_uniprotkb": "pdlim2; fi15c05; wu:fi15c05", "gene_names_refseq": "fi15c05; pdlim2; wu:fi15c05", "protein_names_uniprotkb": "PDZ and LIM domain protein 2", "protein_names_refseq": "PDZ and LIM domain protein 2; PDZ-LIM protein; mystique", "tax_id": 7955, "disease": "", "pathway": " (dre:560322)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17045553;19393641;24004948;26469318;27189481;29462671;34415582", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006589.1, GFIL01016792.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505387, SAMEA4476730 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1 and EB977268.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1QCW0", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031941 filamentous actin", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M3AVD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AVG1-1", "uniprot_id": "A0A8M3AVG1_DANRE", "mass": 261160.0, "length": 2379, "protein_name": "Nuclear receptor corepressor 2", "gene_name": "ncor2", "organism": "Zebrafish", "refseq_name": "nuclear receptor corepressor 2 isoform X1", "refseq_ac": "XP_009302460", "gene_names_uniprotkb": "ncor2; SMRT; gb:be017685; si:bz71m17.2", "gene_names_refseq": "SMRT; gb:be017685; ncor2; si:bz71m17.2", "protein_names_uniprotkb": "Nuclear receptor corepressor 2; Silencing mediator of retinoic acid and thyroid hormone receptor; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor", "protein_names_refseq": "nuclear receptor corepressor 2 isoform X1", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); myelofibrosis (Disease Ontology:DOID:4971); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dre:561503)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17997606;19735730;21571218;21767619;23306105;29027256;30448381;32114246;32179471;34315984", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G7L1;A0AC58G7L3;A0AC58G7L9;A0AC58G7M0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0060218 hematopoietic stem cell differentiation;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AVG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B2L0-1", "uniprot_id": "A0A8M3B2L0_DANRE", "mass": 145838.0, "length": 1306, "protein_name": "Diacylglycerol kinase", "gene_name": "dgkh", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase eta isoform X1", "refseq_ac": "XP_009302858", "gene_names_uniprotkb": "dgkh", "gene_names_refseq": "dgkh", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase eta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100137124)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009302858.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B2L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWB4-1", "uniprot_id": "A0A8M3AWB4_DANRE", "mass": 74703.0, "length": 667, "protein_name": "E3 ubiquitin-protein ligase Midline-1", "gene_name": "mid1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase Midline-1 isoform X1", "refseq_ac": "XP_002663478", "gene_names_uniprotkb": "mid1", "gene_names_refseq": "mid1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Midline-1; 2.3.2.27; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18", "protein_names_refseq": "E3 ubiquitin-protein ligase Midline-1 isoform X1", "tax_id": 7955, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (dre:100330952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GI65;A0AC58GI72;A0AC58GIA5;E7FAU0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWQ3-1", "uniprot_id": "A0A8M3AWQ3_DANRE", "mass": 56220.0, "length": 504, "protein_name": "apyrase", "gene_name": "entpd2b", "organism": "Zebrafish", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 2", "refseq_ac": "XP_009293510", "gene_names_uniprotkb": "entpd2b", "gene_names_refseq": "entpd2b", "protein_names_uniprotkb": "apyrase; 3.6.1.5", "protein_names_refseq": "ectonucleoside triphosphate diphosphohydrolase 2", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dre:569142)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.1.6;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0046688 response to copper ion;GO:0009134 nucleoside diphosphate catabolic process;GO:0071405 cellular response to methanol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AX14-1", "uniprot_id": "A0A8M3AX14_DANRE", "mass": 30301.0, "length": 284, "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "cxxc5a", "organism": "Zebrafish", "refseq_name": "CXXC-type zinc finger protein 5 isoform X1", "refseq_ac": "XP_005161439", "gene_names_uniprotkb": "cxxc5a", "gene_names_refseq": "cxxc5a", "protein_names_uniprotkb": "CXXC-type zinc finger protein 5", "protein_names_refseq": "CXXC-type zinc finger protein 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557911)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161439.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q311", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002040 sprouting angiogenesis;GO:0001947 heart looping;GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AX14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AXZ2-1", "uniprot_id": "A0A8M3AXZ2_DANRE", "mass": 109068.0, "length": 965, "protein_name": "Potassium voltage-gated channel subfamily H member 1b isoform X1", "gene_name": "kcnh1b", "organism": "Zebrafish", "refseq_name": "potassium voltage-gated channel subfamily H member 1b isoform X1", "refseq_ac": "XP_009294796", "gene_names_uniprotkb": "kcnh1b; Eag1; Kv10.1", "gene_names_refseq": "Eag1; Kv10.1; kcnh1b", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily H member 1b isoform X1", "protein_names_refseq": "potassium voltage-gated channel subfamily H member 1b isoform X1", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); epilepsy (Disease Ontology:DOID:1826); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005516 calmodulin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0098793 presynapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0001756 somitogenesis;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0071805 potassium ion transmembrane transport;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AXZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AY27-1", "uniprot_id": "A0A8M3AY27_DANRE", "mass": 143315.0, "length": 1247, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "taok2b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase TAO2 isoform X1", "refseq_ac": "XP_009304676", "gene_names_uniprotkb": "taok2b", "gene_names_refseq": "taok2b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase TAO2 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dre:100151551)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009304676.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0030901 midbrain development;GO:0046330 positive regulation of JNK cascade;GO:0032874 positive regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AY27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B099-1", "uniprot_id": "A0A8M3B099_DANRE", "mass": 77794.0, "length": 679, "protein_name": "Microtubule-associated protein 9 isoform X1", "gene_name": "map9", "organism": "Zebrafish", "refseq_name": "microtubule-associated protein 9 isoform X1", "refseq_ac": "XP_009289323", "gene_names_uniprotkb": "map9; ASAP; a0274750; df:a0274750; im:7158971; si:ch73-34b5.1; xx:a0274750", "gene_names_refseq": "ASAP; a0274750; df:a0274750; im:7158971; map9; si:ch73-34b5.1; xx:a0274750", "protein_names_uniprotkb": "Microtubule-associated protein 9 isoform X1", "protein_names_refseq": "microtubule-associated protein 9 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009289323.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005813 centrosome;GO:0005874 microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0000281 mitotic cytokinesis;GO:1902412 regulation of mitotic cytokinesis;GO:0055113 epiboly involved in gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B0D2-1", "uniprot_id": "A0A8M3B0D2_DANRE", "mass": 192580.0, "length": 1730, "protein_name": "Pappalysin-2 isoform X2", "gene_name": "pappa2", "organism": "Zebrafish", "refseq_name": "pappalysin-2 isoform X2", "refseq_ac": "XP_009296921", "gene_names_uniprotkb": "pappa2", "gene_names_refseq": "pappa2", "protein_names_uniprotkb": "Pappalysin-2 isoform X2", "protein_names_refseq": "pappalysin-2 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:567038); (R-DRE-381426)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008233 peptidase activity;GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0051216 cartilage development;GO:0030903 notochord development;GO:0008593 regulation of Notch signaling pathway;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B0G1-1", "uniprot_id": "A0A8M3B0G1_DANRE", "mass": 46700.0, "length": 419, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "LOC103911233", "organism": "Zebrafish", "refseq_name": "kynurenine--oxoglutarate transaminase 3", "refseq_ac": "XP_009300661", "gene_names_uniprotkb": "LOC103911233", "gene_names_refseq": "LOC103911233", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "kynurenine--oxoglutarate transaminase 3", "tax_id": 7955, "disease": "", "pathway": " (dre:103911233)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.4.1.13;2.6.1.63;2.6.1.7;2.6.1.39;2.6.1.4;2.6.1.73;2.6.1.1", "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B0G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B2M9-1", "uniprot_id": "A0A8M3B2M9_DANRE", "mass": 270208.0, "length": 2438, "protein_name": "Nuclear receptor corepressor 1 isoform X1", "gene_name": "ncor1", "organism": "Zebrafish", "refseq_name": "nuclear receptor corepressor 1 isoform 1", "refseq_ac": "NP_001429912", "gene_names_uniprotkb": "ncor1; ncor; zgc:56355", "gene_names_refseq": "ncor1; ncor; zgc:56355", "protein_names_uniprotkb": "Nuclear receptor corepressor 1 isoform X1", "protein_names_refseq": "nuclear receptor co-repressor 1; nuclear receptor corepressor 1 isoform 1", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); polycystic ovary syndrome (Disease Ontology:DOID:11612); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.455555.1, SRR26395028.379585.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Sep 3, 2025 this sequence version replaced XP_009299902.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0030902 hindbrain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B2M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B2U7-1", "uniprot_id": "A0A8M3B2U7_DANRE", "mass": 119224.0, "length": 1048, "protein_name": "Guanylate cyclase", "gene_name": "npr2", "organism": "Zebrafish", "refseq_name": "atrial natriuretic peptide receptor 2 isoform X1", "refseq_ac": "XP_009300100", "gene_names_uniprotkb": "npr2", "gene_names_refseq": "npr2", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "atrial natriuretic peptide receptor 2 isoform X1", "tax_id": 7955, "disease": "Miura type epiphyseal chondrodysplasia (Disease Ontology:DOID:0070316); bone development disease (Disease Ontology:DOID:0080006); acromesomelic dysplasia, Maroteaux type (Disease Ontology:DOID:0080050); essential hypertension (Disease Ontology:DOID:10825); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (dre:100331745)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009300100.1. COMPLETENESS: full length., [RefSeq]; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0017046 peptide hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0001503 ossification;GO:0060038 cardiac muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B2U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B3H5-1", "uniprot_id": "A0A8M3B3H5_DANRE", "mass": 56649.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr147", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like", "refseq_ac": "XP_009303811", "gene_names_uniprotkb": "pimr147", "gene_names_refseq": "pimr147", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:794008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303811.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B3Q2-1", "uniprot_id": "A0A8M3B3Q2_DANRE", "mass": 37203.0, "length": 336, "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "nfyc", "organism": "Zebrafish", "refseq_name": "nuclear transcription factor Y subunit gamma isoform X3", "refseq_ac": "XP_009292655", "gene_names_uniprotkb": "nfyc; fb98f01; wu:fb98f01; zgc:55514", "gene_names_refseq": "fb98f01; nfyc; wu:fb98f01; zgc:55514", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C", "protein_names_refseq": "nuclear transcription factor Y subunit gamma isoform X3", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QT72;A0AC58HXG2;A0AC58HXH8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B3Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P2N6-1", "uniprot_id": "A0A8M9P2N6_DANRE", "mass": 111578.0, "length": 994, "protein_name": "Ephrin type-A receptor 7", "gene_name": "epha7", "organism": "Zebrafish", "refseq_name": "ephrin type-A receptor 7 isoform X6", "refseq_ac": "XP_021324142", "gene_names_uniprotkb": "epha7; fc51g03; si:dkey-23k6.1; wu:fc51g03", "gene_names_refseq": "epha7; fc51g03; si:dkey-23k6.1; wu:fc51g03", "protein_names_uniprotkb": "Ephrin type-A receptor 7; 2.7.10.1", "protein_names_refseq": "ephrin type-A receptor 7 isoform X6", "tax_id": 7955, "disease": "", "pathway": " (dre:562195); (R-DRE-2682334); (R-DRE-3928663); (R-DRE-3928665)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "20809932;24422634;26190107;27287807;28252024;29911973;31042481;40044042;8806819", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2;3.6.5.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0006915 apoptotic process;GO:0007411 axon guidance;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8M9P2N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YV43-1", "uniprot_id": "A0A8M6YV43_DANRE", "mass": 52975.0, "length": 467, "protein_name": "Stress-activated protein kinase JNK", "gene_name": "mapk10", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase 10 isoform X4", "refseq_ac": "XP_017208303", "gene_names_uniprotkb": "mapk10; zgc:123234", "gene_names_refseq": "mapk10; zgc:123234", "protein_names_uniprotkb": "Stress-activated protein kinase JNK; 2.7.11.24", "protein_names_refseq": "mitogen-activated protein kinase 10 isoform X4", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (dre:569698)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11726686;20564202;21047546;21925157;23468645;25013167;35700135;36229514;36716661;37207274", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I9S4", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity;GO:0004705 JUN kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0001889 liver development;GO:0048511 rhythmic process;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6YV43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P377-1", "uniprot_id": "A0A8M9P377_DANRE", "mass": 101270.0, "length": 904, "protein_name": "Glutamate receptor", "gene_name": "gria4b", "organism": "Zebrafish", "refseq_name": "glutamate receptor 4b isoform X1", "refseq_ac": "XP_021324447", "gene_names_uniprotkb": "gria4b; ZfGluR4b; fj46g06; glur4b; wu:fj46g06", "gene_names_refseq": "ZfGluR4b; fj46g06; glur4b; gria4b; wu:fj46g06", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor 4b isoform X1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:336069); (R-DRE-399710); (R-DRE-416993); (R-DRE-438066); (R-DRE-8849932)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "16887104;18202183;18224707;19481010;26235327;33872356;33975920;35877057;36414621;36737489", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0016020 membrane;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9P377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YYR6-1", "uniprot_id": "A0A8M6YYR6_DANRE", "mass": 132880.0, "length": 1199, "protein_name": "Par-3 family cell polarity regulator beta a isoform X1", "gene_name": "pard3ba", "organism": "Zebrafish", "refseq_name": "par-3 family cell polarity regulator beta a isoform X1", "refseq_ac": "XP_017211256", "gene_names_uniprotkb": "pard3ba; im:7153558; im:7153839; si:ch1073-345a8.1", "gene_names_refseq": "im:7153558; im:7153839; pard3ba; si:ch1073-345a8.1", "protein_names_uniprotkb": "Par-3 family cell polarity regulator beta a isoform X1", "protein_names_refseq": "par-3 family cell polarity regulator beta a isoform X1", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (dre:100149472)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;32179471", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0016324 apical plasma membrane;GO:0043296 apical junction complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0051301 cell division;GO:0008104 intracellular protein localization;GO:0000226 microtubule cytoskeleton organization;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M6YYR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B604-1", "uniprot_id": "A0A8M3B604_DANRE", "mass": 204080.0, "length": 1778, "protein_name": "Chromodomain-helicase-DNA-binding protein 1 isoform X1", "gene_name": "chd1", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 1 isoform X1", "refseq_ac": "XP_009303375", "gene_names_uniprotkb": "chd1; fc26h11; fk85d05; si:dkey-106m21.4; wu:fc26h11; wu:fk85d05; zgc:173506", "gene_names_refseq": "chd1; fc26h11; fk85d05; si:dkey-106m21.4; wu:fc26h11; wu:fk85d05; zgc:173506", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 1 isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 1 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:563236)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18335061;24240475;25386660;27189481;27418670;33914867", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GK99", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003678 DNA helicase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0034728 nucleosome organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3B604-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B449-1", "uniprot_id": "A0A8M3B449_DANRE", "mass": 89793.0, "length": 824, "protein_name": "Protein enabled homolog", "gene_name": "enah", "organism": "Zebrafish", "refseq_name": "protein enabled homolog isoform X1", "refseq_ac": "XP_009292985", "gene_names_uniprotkb": "enah; id:ibd2798; si:ch211-215p14.1; zgc:103638", "gene_names_refseq": "enah; id:ibd2798; si:ch211-215p14.1; zgc:103638", "protein_names_uniprotkb": "Protein enabled homolog", "protein_names_refseq": "protein enabled homolog isoform X1", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); tauopathy (Disease Ontology:DOID:680); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:541394)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11731487;19646228;22355335;26469318;27156127;27189481;28252024;32494702", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009292985.1. COMPLETENESS: full length., [RefSeq]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0030027 lamellipodium;GO:0045202 synapse", "go_biological_process": "GO:0070358 actin polymerization-dependent cell motility;GO:0008154 actin polymerization or depolymerization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M3B449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z8R4-1", "uniprot_id": "A0A8M6Z8R4_DANRE", "mass": 57893.0, "length": 511, "protein_name": "Scavenger receptor class B member 1", "gene_name": "scarb1", "organism": "Zebrafish", "refseq_name": "scavenger receptor class B member 1 isoform X1", "refseq_ac": "XP_017213428", "gene_names_uniprotkb": "scarb1; cb1015", "gene_names_refseq": "cb1015; scarb1", "protein_names_uniprotkb": "Scavenger receptor class B member 1; SR-BI", "protein_names_refseq": "scavenger receptor class B member 1 isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); sensorineural hearing loss (Disease Ontology:DOID:10003); morbid obesity (Disease Ontology:DOID:11981); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dre:387260)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "25306962;26743566;27879346;28096348;28851829;33742021;34119630;35247629;36931457;37435570;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0008289 lipid binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005901 caveola;GO:0009986 cell surface", "go_biological_process": "GO:0048070 regulation of developmental pigmentation;GO:0080154 regulation of fertilization;GO:0033344 cholesterol efflux;GO:0070508 cholesterol import;GO:0034381 plasma lipoprotein particle clearance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M6Z8R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YYJ8-1", "uniprot_id": "A0A8M6YYJ8_DANRE", "mass": 79068.0, "length": 722, "protein_name": "Cadherin-related family member 5 isoform X1", "gene_name": "cdhr5b", "organism": "Zebrafish", "refseq_name": "cadherin-related family member 5 isoform X1", "refseq_ac": "XP_017209750", "gene_names_uniprotkb": "cdhr5b", "gene_names_refseq": "cdhr5b", "protein_names_uniprotkb": "Cadherin-related family member 5 isoform X1", "protein_names_refseq": "cadherin-related family member 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886483)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017209750.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YYJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PE84-1", "uniprot_id": "A0A8M9PE84_DANRE", "mass": 99947.0, "length": 920, "protein_name": "Gephyrin", "gene_name": "gphna", "organism": "Zebrafish", "refseq_name": "gephyrin a isoform X1", "refseq_ac": "XP_021322844", "gene_names_uniprotkb": "gphna; gpgb1", "gene_names_refseq": "gpgb1; gphna", "protein_names_uniprotkb": "Gephyrin; 2.10.1.1; 2.7.7.75", "protein_names_refseq": "gephyrin a isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); molybdenum cofactor deficiency type C (Disease Ontology:DOID:0111166); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.10.1.1;2.7.7.75", "go_molecular_function": "GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0072579 glycine receptor clustering;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PE84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YZ52-1", "uniprot_id": "A0A8M6YZ52_DANRE", "mass": 265091.0, "length": 2349, "protein_name": "acetyl-CoA carboxylase", "gene_name": "acaca", "organism": "Zebrafish", "refseq_name": "acetyl-CoA carboxylase 1 isoform X14", "refseq_ac": "XP_017211606", "gene_names_uniprotkb": "acaca; acc; fj43d01; im:7138837; si:ch211-199d18.1; wu:fj43d01", "gene_names_refseq": "acaca; acc; fj43d01; im:7138837; si:ch211-199d18.1; wu:fj43d01", "protein_names_uniprotkb": "acetyl-CoA carboxylase; 6.4.1.2", "protein_names_refseq": "acetyl-CoA carboxylase 1 isoform X14", "tax_id": 7955, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:559403)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18297735;19127516;19451134;21538441;21722753;38788853;38798028;39069827;39139065;39519205", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JJF4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0061959 response to (R)-carnitine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M6YZ52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z2S8-1", "uniprot_id": "A0A8M6Z2S8_DANRE", "mass": 181734.0, "length": 1629, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "rapgef2b", "organism": "Zebrafish", "refseq_name": "rap guanine nucleotide exchange factor 2 isoform X1", "refseq_ac": "XP_017214662", "gene_names_uniprotkb": "rapgef2b", "gene_names_refseq": "rapgef2b", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; RA-GEF-1; Ras/Rap1-associating GEF-1", "protein_names_refseq": "rap guanine nucleotide exchange factor 2 isoform X1", "tax_id": 7955, "disease": "familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694)", "pathway": " (dre:557693)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0070161 anchoring junction", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BCT9-1", "uniprot_id": "A0A8M3BCT9_DANRE", "mass": 147342.0, "length": 1310, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase", "gene_name": "ppip5k2", "organism": "Zebrafish", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1", "refseq_ac": "XP_009303388", "gene_names_uniprotkb": "ppip5k2", "gene_names_refseq": "ppip5k2", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; 2.7.4.24", "protein_names_refseq": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1", "tax_id": 7955, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal recessive nonsyndromic deafness 100 (Disease Ontology:DOID:0111638); keratoconus (Disease Ontology:DOID:10126)", "pathway": " (dre:449862)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.4.24", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z3W4-1", "uniprot_id": "A0A8M6Z3W4_DANRE", "mass": 211956.0, "length": 1891, "protein_name": "Plexin-A1", "gene_name": "plxna1a", "organism": "Zebrafish", "refseq_name": "plexin-A1 isoform X1", "refseq_ac": "XP_017209175", "gene_names_uniprotkb": "plxna1a", "gene_names_refseq": "plxna1a", "protein_names_uniprotkb": "Plexin-A1", "protein_names_refseq": "plexin-A1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:795761)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017209175.1. COMPLETENESS: full length., [RefSeq]; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0002116 semaphorin receptor complex", "go_biological_process": "GO:0002072 optic cup morphogenesis involved in camera-type eye development;GO:0007411 axon guidance;GO:0001763 morphogenesis of a branching structure;GO:0097485 neuron projection guidance;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z3W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YTG2-1", "uniprot_id": "A0A8M6YTG2_DANRE", "mass": 35038.0, "length": 317, "protein_name": "Uridine phosphorylase", "gene_name": "upp1", "organism": "Zebrafish", "refseq_name": "uridine phosphorylase 1 isoform X1", "refseq_ac": "XP_017206833", "gene_names_uniprotkb": "upp1; im:6911242; zgc:110755", "gene_names_refseq": "im:6911242; upp1; zgc:110755", "protein_names_uniprotkb": "Uridine phosphorylase; 2.4.2.3", "protein_names_refseq": "uridine phosphorylase 1 isoform X1", "tax_id": 7955, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.3", "go_molecular_function": "GO:0004850 uridine phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0044206 UMP salvage;GO:0009166 nucleotide catabolic process;GO:0009164 nucleoside catabolic process;GO:0006218 uridine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YTG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P1Q4-1", "uniprot_id": "A0A8M9P1Q4_DANRE", "mass": 52377.0, "length": 467, "protein_name": "Epsilon-sarcoglycan", "gene_name": "sgce", "organism": "Zebrafish", "refseq_name": "epsilon-sarcoglycan isoform X1", "refseq_ac": "XP_021323677", "gene_names_uniprotkb": "sgce; scge; zgc:92318", "gene_names_refseq": "scge; sgce; zgc:92318", "protein_names_uniprotkb": "Epsilon-sarcoglycan", "protein_names_refseq": "epsilon-sarcoglycan isoform X1", "tax_id": 7955, "disease": "myoclonic dystonia 11 (Disease Ontology:DOID:0090034); stomach cancer (Disease Ontology:DOID:10534)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0042383 sarcolemma;GO:0016012 sarcoglycan complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P1Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P333-1", "uniprot_id": "A0A8M9P333_DANRE", "mass": 96552.0, "length": 863, "protein_name": "phosphatidate phosphatase", "gene_name": "lpin1b", "organism": "Zebrafish", "refseq_name": "phosphatidate phosphatase LPIN1 isoform X1", "refseq_ac": "XP_021324377", "gene_names_uniprotkb": "lpin1b", "gene_names_refseq": "lpin1b", "protein_names_uniprotkb": "phosphatidate phosphatase; 3.1.3.4", "protein_names_refseq": "phosphatidate phosphatase LPIN1 isoform X1", "tax_id": 7955, "disease": "myoglobinuria (Disease Ontology:DOID:0080108); morbid obesity (Disease Ontology:DOID:11981); lipid metabolism disorder (Disease Ontology:DOID:3146); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:560638)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324377.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P333-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B4V1-1", "uniprot_id": "A0A8M3B4V1_DANRE", "mass": 86986.0, "length": 782, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase MARK2 isoform X1", "refseq_ac": "XP_009293774", "gene_names_uniprotkb": "mark2a", "gene_names_refseq": "mark2a", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase MARK2 isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:562231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B6G9-1", "uniprot_id": "A0A8M3B6G9_DANRE", "mass": 133135.0, "length": 1166, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 25", "gene_name": "usp25", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 25 isoform X1", "refseq_ac": "XP_009303832", "gene_names_uniprotkb": "usp25; wu:fi33c05; wu:fo67e06; wu:fp97a04; zgc:55791", "gene_names_refseq": "usp25; wu:fi33c05; wu:fo67e06; wu:fp97a04; zgc:55791", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 25; 3.4.19.12; Deubiquitinating enzyme 25; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 25 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303832.1. COMPLETENESS: full length., [RefSeq]; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0009953 dorsal/ventral pattern formation;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B6G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B5I3-1", "uniprot_id": "A0A8M3B5I3_DANRE", "mass": 159441.0, "length": 1423, "protein_name": "Calmodulin-regulated spectrin-associated protein 2a isoform X1", "gene_name": "camsap2a", "organism": "Zebrafish", "refseq_name": "calmodulin-regulated spectrin-associated protein 2a isoform X1", "refseq_ac": "XP_009294535", "gene_names_uniprotkb": "camsap2a; camsap1l1; camsap2; si:dkey-39e8.1; wu:fc16g04; wu:fc23h08", "gene_names_refseq": "camsap1l1; camsap2a; camsap2; si:dkey-39e8.1; wu:fc16g04; wu:fc23h08", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 2a isoform X1", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562741)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16109975;20423468;22421047;28252024;29229769;29547120", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009294535.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0031175 neuron projection development;GO:0007026 negative regulation of microtubule depolymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3B5I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PBT0-1", "uniprot_id": "A0A8M9PBT0_DANRE", "mass": 69011.0, "length": 620, "protein_name": "Sorting nexin", "gene_name": "snx9b", "organism": "Zebrafish", "refseq_name": "sorting nexin-9b isoform X1", "refseq_ac": "XP_021324123", "gene_names_uniprotkb": "snx9b; si:dkeyp-70e6.2; snx9l; wu:fj22c06; wu:fj94b09; wu:fk76d01", "gene_names_refseq": "si:dkeyp-70e6.2; snx9b; snx9l; wu:fj22c06; wu:fj94b09; wu:fk76d01", "protein_names_uniprotkb": "Sorting nexin", "protein_names_refseq": "sorting nexin-9b isoform X1", "tax_id": 7955, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0000281 mitotic cytokinesis;GO:0016197 endosomal transport;GO:0036089 cleavage furrow formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PBT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z878-1", "uniprot_id": "A0A8M6Z878_DANRE", "mass": 87751.0, "length": 801, "protein_name": "Kin of IRRE-like protein 1", "gene_name": "kirrel1b", "organism": "Zebrafish", "refseq_name": "kin of IRRE-like protein 1b isoform X1", "refseq_ac": "XP_017212964", "gene_names_uniprotkb": "kirrel1b; kirrelb; si:ch211-195h23.2", "gene_names_refseq": "kirrel1b; kirrelb; si:ch211-195h23.2", "protein_names_uniprotkb": "Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1", "protein_names_refseq": "kin of IRRE-like protein 1b isoform X1", "tax_id": 7955, "disease": "nephrotic syndrome type 23 (Disease Ontology:DOID:0112266); nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0072015 podocyte development;GO:0032836 glomerular basement membrane development;GO:0039022 pronephric duct development;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BAY3-1", "uniprot_id": "A0A8M3BAY3_DANRE", "mass": 122389.0, "length": 1100, "protein_name": "Diacylglycerol kinase", "gene_name": "si:dkey-172j4.3", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase delta isoform X1", "refseq_ac": "XP_009301401", "gene_names_uniprotkb": "si:dkey-172j4.3", "gene_names_refseq": "si:dkey-172j4.3", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase delta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565122)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process;GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BAY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z9M1-1", "uniprot_id": "A0A8M6Z9M1_DANRE", "mass": 79686.0, "length": 730, "protein_name": "Phosphatidylinositol-binding clathrin assembly protein", "gene_name": "picalmb", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol binding clathrin assembly protein b isoform X1", "refseq_ac": "XP_017214722", "gene_names_uniprotkb": "picalmb; fa01d03; picalml; picalm; wu:fa01d03; wu:fa05d03; wu:fb69g01; wu:fe17e02; zgc:91993", "gene_names_refseq": "fa01d03; picalmb; picalml; picalm; wu:fa01d03; wu:fa05d03; wu:fb69g01; wu:fe17e02; zgc:91993", "protein_names_uniprotkb": "Phosphatidylinositol-binding clathrin assembly protein", "protein_names_refseq": "phosphatidylinositol binding clathrin assembly protein b isoform X1", "tax_id": 7955, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005545 1-phosphatidylinositol binding;GO:0030276 clathrin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0000149 SNARE binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0006900 vesicle budding from membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z9M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P0L3-1", "uniprot_id": "A0A8M9P0L3_DANRE", "mass": 116376.0, "length": 1044, "protein_name": "Glutamate receptor", "gene_name": "grid1a", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, delta-1 isoform X1", "refseq_ac": "XP_021323097", "gene_names_uniprotkb": "grid1a", "gene_names_refseq": "grid1a", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, delta-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021323097.1. COMPLETENESS: full length., [RefSeq]; Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098839 postsynaptic density membrane;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P0L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PDC8-1", "uniprot_id": "A0A8M9PDC8_DANRE", "mass": 668829.0, "length": 5908, "protein_name": "Plectin isoform X1", "gene_name": "plecb", "organism": "Zebrafish", "refseq_name": "plectin isoform X1", "refseq_ac": "XP_021322489", "gene_names_uniprotkb": "plecb", "gene_names_refseq": "plecb", "protein_names_uniprotkb": "Plectin isoform X1", "protein_names_refseq": "plectin isoform X1", "tax_id": 7955, "disease": "epidermolysis bullosa simplex 5A Ogna type (Disease Ontology:DOID:0060736); epidermolysis bullosa simplex with muscular dystrophy (Disease Ontology:DOID:0090017); autosomal recessive limb-girdle muscular dystrophy type 2Q (Disease Ontology:DOID:0110285); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (dre:100321011)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021322489.1. COMPLETENESS: full length., [RefSeq]; Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0042383 sarcolemma;GO:0030016 myofibril;GO:0042995 cell projection;GO:0030057 desmosome", "go_biological_process": "GO:0007507 heart development;GO:0007626 locomotory behavior;GO:0061436 establishment of skin barrier;GO:0060047 heart contraction;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PDC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B9P5-1", "uniprot_id": "A0A8M3B9P5_DANRE", "mass": 136959.0, "length": 1244, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "stk36", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase 36 isoform X1", "refseq_ac": "XP_009299810", "gene_names_uniprotkb": "stk36; fu; si:dkey-180i4.3; zgc:152944", "gene_names_refseq": "fu; si:dkey-180i4.3; stk36; zgc:152944", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1; Fused homolog", "protein_names_refseq": "serine/threonine-protein kinase 36 isoform X1", "tax_id": 7955, "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007368 determination of left/right symmetry;GO:0009953 dorsal/ventral pattern formation;GO:0007224 smoothened signaling pathway;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B9P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BAY8-1", "uniprot_id": "A0A8M3BAY8_DANRE", "mass": 87465.0, "length": 790, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark2b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase MARK2 isoform X1", "refseq_ac": "XP_009301419", "gene_names_uniprotkb": "mark2b", "gene_names_refseq": "mark2b", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase MARK2 isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:100005996)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BAY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B4X6-1", "uniprot_id": "A0A8M3B4X6_DANRE", "mass": 403862.0, "length": 3666, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 3", "gene_name": "celsr3", "organism": "Zebrafish", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 3 isoform X1", "refseq_ac": "XP_009302289", "gene_names_uniprotkb": "celsr3", "gene_names_refseq": "celsr3", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 3; Multiple epidermal growth factor-like domains protein 2", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100008568)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0021510 spinal cord development;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B4X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z2L7-1", "uniprot_id": "A0A8M6Z2L7_DANRE", "mass": 335588.0, "length": 2968, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "kalrna", "organism": "Zebrafish", "refseq_name": "kalirin isoform X1", "refseq_ac": "XP_017213230", "gene_names_uniprotkb": "kalrna", "gene_names_refseq": "kalrna", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "kalirin isoform X1", "tax_id": 7955, "disease": "cerebral atherosclerosis (Disease Ontology:DOID:12720); epilepsy (Disease Ontology:DOID:1826); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (dre:100148988)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017213230.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0019898 extrinsic component of membrane", "go_biological_process": "GO:0030097 hemopoiesis;GO:0035556 intracellular signal transduction;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2L7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B546-1", "uniprot_id": "A0A8M3B546_DANRE", "mass": 177208.0, "length": 1615, "protein_name": "Uncharacterized protein rab11fip5a isoform X1", "gene_name": "rab11fip5a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein rab11fip5a isoform X1", "refseq_ac": "XP_009305486", "gene_names_uniprotkb": "rab11fip5a", "gene_names_refseq": "rab11fip5a", "protein_names_uniprotkb": "Uncharacterized protein rab11fip5a isoform X1", "protein_names_refseq": "uncharacterized protein rab11fip5a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562719)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0055037 recycling endosome;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0030141 secretory granule;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:1902896 terminal web assembly;GO:0015031 protein transport;GO:0048565 digestive tract development;GO:0032528 microvillus organization;GO:0045055 regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B546-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BER5-1", "uniprot_id": "A0A8M3BER5_DANRE", "mass": 226662.0, "length": 2044, "protein_name": "histone acetyltransferase", "gene_name": "kat6b", "organism": "Zebrafish", "refseq_name": "histone acetyltransferase KAT6B isoform X1", "refseq_ac": "XP_009305666", "gene_names_uniprotkb": "kat6b", "gene_names_refseq": "kat6b", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "histone acetyltransferase KAT6B isoform X1", "tax_id": 7955, "disease": "Ohdo syndrome, SBBYS variant (Disease Ontology:DOID:0060290); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); bipolar disorder (Disease Ontology:DOID:3312); Noonan syndrome (Disease Ontology:DOID:3490)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;2.3.1.259;2.3.1.57", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0003682 chromatin binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome;GO:0070775 H3 histone acetyltransferase complex;GO:0000785 chromatin;GO:0070776 MOZ/MORF histone acetyltransferase complex", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BER5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BEY4-1", "uniprot_id": "A0A8M3BEY4_DANRE", "mass": 59076.0, "length": 522, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "ppp3cb", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1", "refseq_ac": "XP_009305997", "gene_names_uniprotkb": "ppp3cb; wu:fq19c08; zgc:110141", "gene_names_refseq": "ppp3cb; wu:fq19c08; zgc:110141", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0033173 calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BEY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BCZ5-1", "uniprot_id": "A0A8M3BCZ5_DANRE", "mass": 104315.0, "length": 919, "protein_name": "Glutamate receptor", "gene_name": "grik1a", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 1 isoform X1", "refseq_ac": "XP_009303592", "gene_names_uniprotkb": "grik1a", "gene_names_refseq": "grik1a", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 1 isoform X1", "tax_id": 7955, "disease": "status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009303592.1. COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BCZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B534-1", "uniprot_id": "A0A8M3B534_DANRE", "mass": 124204.0, "length": 1126, "protein_name": "Solute carrier family 12 member 5b isoform X1", "gene_name": "slc12a5b", "organism": "Zebrafish", "refseq_name": "solute carrier family 12 member 5b isoform X1", "refseq_ac": "XP_009302423", "gene_names_uniprotkb": "slc12a5b; kcc2b; si:dkey-253e7.2", "gene_names_refseq": "kcc2b; si:dkey-253e7.2; slc12a5b", "protein_names_uniprotkb": "Solute carrier family 12 member 5b isoform X1", "protein_names_refseq": "solute carrier family 12 member 5b isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 34 (Disease Ontology:DOID:0080460); epilepsy (Disease Ontology:DOID:1826)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:0060041 retina development in camera-type eye;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B5M8-1", "uniprot_id": "A0A8M3B5M8_DANRE", "mass": 72779.0, "length": 638, "protein_name": "Zinc finger CCHC domain-containing protein 7", "gene_name": "zcchc7", "organism": "Zebrafish", "refseq_name": "zinc finger CCHC domain-containing protein 7 isoform X1", "refseq_ac": "XP_009306003", "gene_names_uniprotkb": "zcchc7; chunp6893; flj22611l; zcchc7l", "gene_names_refseq": "chunp6893; flj22611l; zcchc7l; zcchc7", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 7; TRAMP-like complex RNA-binding factor ZCCHC7", "protein_names_refseq": "zinc finger CCHC domain-containing protein 7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:317641)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12006978;22182705;26469318;27189481;31237961", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009306003.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038 TRAMP-dependent tRNA surveillance pathway;GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process;GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process;GO:0071039 nuclear polyadenylation-dependent CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3B5M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B8F4-1", "uniprot_id": "A0A8M3B8F4_DANRE", "mass": 131967.0, "length": 1165, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "si:zfos-2326c3.2", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 4 isoform X1", "refseq_ac": "XP_009306038", "gene_names_uniprotkb": "si:zfos-2326c3.2", "gene_names_refseq": "si:zfos-2326c3.2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase kinase 4 isoform X1", "tax_id": 7955, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:561669)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B8F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z1B7-1", "uniprot_id": "A0A8M6Z1B7_DANRE", "mass": 88525.0, "length": 804, "protein_name": "Zinc finger protein GLIS3 isoform X1", "gene_name": "glis3", "organism": "Zebrafish", "refseq_name": "zinc finger protein GLIS3 isoform X1", "refseq_ac": "XP_017213470", "gene_names_uniprotkb": "glis3; wu:fa55a05; zgc:158249", "gene_names_refseq": "glis3; wu:fa55a05; zgc:158249", "protein_names_uniprotkb": "Zinc finger protein GLIS3 isoform X1", "protein_names_refseq": "zinc finger protein GLIS3 isoform X1", "tax_id": 7955, "disease": "neonatal diabetes mellitus with congenital hypothyroidism (Disease Ontology:DOID:0060638); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:571000)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;25026003;25139857;26469318;26963759;30555422;31797737", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:1990798 pancreas regeneration;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M6Z1B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B615-1", "uniprot_id": "A0A8M3B615_DANRE", "mass": 112845.0, "length": 1016, "protein_name": "Activity-dependent neuroprotector homeobox b isoform X1", "gene_name": "adnpb", "organism": "Zebrafish", "refseq_name": "activity-dependent neuroprotector homeobox b isoform X1", "refseq_ac": "XP_009295051", "gene_names_uniprotkb": "adnpb; adnp1b; adnp; wu:fi72f04", "gene_names_refseq": "adnp1b; adnpb; adnp; wu:fi72f04", "protein_names_uniprotkb": "Activity-dependent neuroprotector homeobox b isoform X1", "protein_names_refseq": "activity-dependent neuroprotector homeobox b isoform X1", "tax_id": 7955, "disease": "Helsmoortel-Van Der Aa Syndrome (Disease Ontology:DOID:0070058); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (dre:100330315)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23071114;26469318;27189481;32533114;36417527", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0043249 erythrocyte maturation;GO:0006351 DNA-templated transcription;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3B615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B6F1-1", "uniprot_id": "A0A8M3B6F1_DANRE", "mass": 28803.0, "length": 253, "protein_name": "Proenkephalin-B", "gene_name": "pdyn", "organism": "Zebrafish", "refseq_name": "proenkephalin-B isoform X1", "refseq_ac": "XP_009295383", "gene_names_uniprotkb": "pdyn; fj38c03; wu:fj38c03", "gene_names_refseq": "fj38c03; pdyn; wu:fj38c03", "protein_names_uniprotkb": "Proenkephalin-B; Beta-neoendorphin-dynorphin; Preprodynorphin", "protein_names_refseq": "proenkephalin-B isoform X1", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); spinocerebellar ataxia 23 (Disease Ontology:DOID:0050973); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); opioid abuse (Disease Ontology:DOID:11206); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); temporal lobe epilepsy (Disease Ontology:DOID:3328); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin., [UniProtKB, UniProtKB]; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress., [UniProtKB, UniProtKB]; Leumorphin has a typical opioid activity and may have anti-apoptotic effect., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IJE1;F1R4H8", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0045202 synapse", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B6F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B7K5-1", "uniprot_id": "A0A8M3B7K5_DANRE", "mass": 148583.0, "length": 1328, "protein_name": "Glutamate receptor", "gene_name": "grin2cb", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, NMDA 2C", "refseq_ac": "XP_009305071", "gene_names_uniprotkb": "grin2cb", "gene_names_refseq": "grin2cb", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 2C", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:100333648)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305071.2. COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GY89;A0AC58GY90;A0AC58GY93;A0AC58GY95;A0AC58GY96;A0AC58GY97;A0AC58GY99;A0AC58GYA3", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0004972 NMDA glutamate receptor activity", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0045211 postsynaptic membrane;GO:0043226 organelle", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B7U5-1", "uniprot_id": "A0A8M3B7U5_DANRE", "mass": 56558.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr157", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2", "refseq_ac": "XP_009305407", "gene_names_uniprotkb": "pimr157", "gene_names_refseq": "pimr157", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2", "tax_id": 7955, "disease": "", "pathway": " (dre:799419)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009305407.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A622", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B7W8-1", "uniprot_id": "A0A8M3B7W8_DANRE", "mass": 52907.0, "length": 454, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-1 isoform X1", "gene_name": "gabrg1", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-1 isoform X1", "refseq_ac": "XP_009305483", "gene_names_uniprotkb": "gabrg1", "gene_names_refseq": "gabrg1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-1 isoform X1", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit gamma-1 isoform X1", "tax_id": 7955, "disease": "trigeminal neuralgia (Disease Ontology:DOID:12098)", "pathway": " (dre:556202)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B7X7-1", "uniprot_id": "A0A8M3B7X7_DANRE", "mass": 94890.0, "length": 824, "protein_name": "Toll-like receptor 4", "gene_name": "tlr4ba", "organism": "Zebrafish", "refseq_name": "toll-like receptor 4b, duplicate a isoform X1", "refseq_ac": "XP_009305503", "gene_names_uniprotkb": "tlr4ba; TIR4.1; tlr4a", "gene_names_refseq": "TIR4.1; tlr4a; tlr4ba", "protein_names_uniprotkb": "Toll-like receptor 4", "protein_names_refseq": "toll-like receptor 4b, duplicate a isoform X1", "tax_id": 7955, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); mastoiditis (Disease Ontology:DOID:0060322); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); meningococcal meningitis (Disease Ontology:DOID:0080176); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); urinary tract infection (Disease Ontology:DOID:0080784); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); dry eye syndrome (Disease Ontology:DOID:10140); dermatomyositis (Disease Ontology:DOID:10223); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); mastitis (Disease Ontology:DOID:10690); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); cholesteatoma of middle ear (Disease Ontology:DOID:10964); pulpitis (Disease Ontology:DOID:11121); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); sciatic neuropathy (Disease Ontology:DOID:11446); suppurative otitis media (Disease Ontology:DOID:11506); hepatorenal syndrome (Disease Ontology:DOID:11823); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); carotid stenosis (Disease Ontology:DOID:13001); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); low tension glaucoma (Disease Ontology:DOID:13544); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); cystic echinococcosis (Disease Ontology:DOID:1495); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); glucose metabolism disease (Disease Ontology:DOID:4194); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); keratitis (Disease Ontology:DOID:4677); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); uric acid nephrolithiasis (Disease Ontology:DOID:580); myocardial infarction (Disease Ontology:DOID:5844); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); lung disease (Disease Ontology:DOID:850); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009305503.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 91, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001530 lipopolysaccharide binding;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0001726 ruffle;GO:0032991 protein-containing complex;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0034142 toll-like receptor 4 signaling pathway;GO:0002755 MyD88-dependent toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B7Z1-1", "uniprot_id": "A0A8M3B7Z1_DANRE", "mass": 221337.0, "length": 1940, "protein_name": "Sodium channel protein", "gene_name": "scn12aa", "organism": "Zebrafish", "refseq_name": "sodium channel, voltage gated, type XII, alpha a isoform X1", "refseq_ac": "XP_009297176", "gene_names_uniprotkb": "scn12aa", "gene_names_refseq": "scn12aa", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "sodium channel, voltage gated, type XII, alpha a isoform X1", "tax_id": 7955, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); Brugada syndrome 1 (Disease Ontology:DOID:0110218); long QT syndrome 3 (Disease Ontology:DOID:0110646); progressive familial heart block type IA (Disease Ontology:DOID:0111074); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); sick sinus syndrome (Disease Ontology:DOID:13884); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009297176.1. COMPLETENESS: full length., [RefSeq]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0008016 regulation of heart contraction;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B7Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B826-1", "uniprot_id": "A0A8M3B826_DANRE", "mass": 64611.0, "length": 565, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "galnt2", "organism": "Zebrafish", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 2 isoform X1", "refseq_ac": "XP_009305623", "gene_names_uniprotkb": "galnt2; im:7140357; si:dkey-162b3.1", "gene_names_refseq": "galnt2; im:7140357; si:dkey-162b3.1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "polypeptide N-acetylgalactosaminyltransferase 2 isoform X1", "tax_id": 7955, "disease": "congenital disorder of glycosylation type IIt (Disease Ontology:DOID:0051049)", "pathway": " (dre:570248)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "24683187;26469318;28252024;28871129;29093022;29420541;31560986;33757938;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0030500 regulation of bone mineralization;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8M3B826-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B909-1", "uniprot_id": "A0A8M3B909_DANRE", "mass": 82355.0, "length": 719, "protein_name": "Protein kinase C", "gene_name": "prkcq", "organism": "Zebrafish", "refseq_name": "protein kinase C theta type isoform X1", "refseq_ac": "XP_009298659", "gene_names_uniprotkb": "prkcq; si:ch211-239o15.1", "gene_names_refseq": "prkcq; si:ch211-239o15.1", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C theta type isoform X1", "tax_id": 7955, "disease": "hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (dre:555521)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17403595;25603810;26469318;29576475;30408601;30716520;31307377;34329618", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001772 immunological synapse", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M3B909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3B9I7-1", "uniprot_id": "A0A8M3B9I7_DANRE", "mass": 121948.0, "length": 1059, "protein_name": "Unconventional myosin-Ic", "gene_name": "myo1ha", "organism": "Zebrafish", "refseq_name": "unconventional myosin-Ih isoform X1", "refseq_ac": "XP_009299653", "gene_names_uniprotkb": "myo1ha", "gene_names_refseq": "myo1ha", "protein_names_uniprotkb": "Unconventional myosin-Ic; Myosin I beta", "protein_names_refseq": "unconventional myosin-Ih isoform X1", "tax_id": 7955, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (dre:556606)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0048731 system development;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3B9I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3BC88-1", "uniprot_id": "A0A8M3BC88_DANRE", "mass": 205673.0, "length": 1857, "protein_name": "Myosin light chain kinase, smooth muscle", "gene_name": "mylka", "organism": "Zebrafish", "refseq_name": "myosin light chain kinase, smooth muscle isoform X1", "refseq_ac": "XP_009302720", "gene_names_uniprotkb": "mylka", "gene_names_refseq": "mylka", "protein_names_uniprotkb": "Myosin light chain kinase, smooth muscle; 2.7.11.18; Telokin", "protein_names_refseq": "myosin light chain kinase, smooth muscle isoform X1", "tax_id": 7955, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); adult respiratory distress syndrome (Disease Ontology:DOID:11394); thoracic aortic aneurysm (Disease Ontology:DOID:14004); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (dre:569510)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009302720.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:2000145 regulation of cell motility;GO:0007596 blood coagulation;GO:0003007 heart morphogenesis;GO:0055013 cardiac muscle cell development;GO:0045989 positive regulation of striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3BC88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YTH1-1", "uniprot_id": "A0A8M6YTH1_DANRE", "mass": 73108.0, "length": 651, "protein_name": "Pannexin", "gene_name": "panx2", "organism": "Zebrafish", "refseq_name": "pannexin-2 isoform X1", "refseq_ac": "XP_017207418", "gene_names_uniprotkb": "panx2; PANX; si:ch211-192n14.2", "gene_names_refseq": "panx2; si:ch211-192n14.2", "protein_names_uniprotkb": "Pannexin", "protein_names_refseq": "pannexin-2 isoform X1", "tax_id": 7955, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:557828); (R-DRE-112303)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Structural component of the gap junctions and the hemichannels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QKJ1", "ec_number_list": "", "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YTH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z1H5-1", "uniprot_id": "A0A8M6Z1H5_DANRE", "mass": 84739.0, "length": 733, "protein_name": "Calpain-3", "gene_name": "capn3a", "organism": "Zebrafish", "refseq_name": "calpain-3 isoform X1", "refseq_ac": "XP_017207114", "gene_names_uniprotkb": "capn3a; capn3; zgc:92687", "gene_names_refseq": "capn3a; capn3; zgc:92687", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54", "protein_names_refseq": "calpain-3 isoform X1", "tax_id": 7955, "disease": "autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YU34-1", "uniprot_id": "A0A8M6YU34_DANRE", "mass": 118442.0, "length": 1063, "protein_name": "Glutamate receptor", "gene_name": "si:ch211-264f5.8", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 5 isoform X1", "refseq_ac": "XP_017207885", "gene_names_uniprotkb": "si:ch211-264f5.8", "gene_names_refseq": "si:ch211-264f5.8", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HZY3", "ec_number_list": "", "go_molecular_function": "GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YU34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YUU4-1", "uniprot_id": "A0A8M6YUU4_DANRE", "mass": 57555.0, "length": 501, "protein_name": "Tyrosine-protein kinase", "gene_name": "blk", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase Blk isoform X1", "refseq_ac": "XP_017208000", "gene_names_uniprotkb": "blk; bltk; si:dkey-33i22.2; zgc:136231", "gene_names_refseq": "blk; bltk; si:dkey-33i22.2; zgc:136231", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Blk isoform X1", "tax_id": 7955, "disease": "maturity-onset diabetes of the young type 11 (Disease Ontology:DOID:0111109); intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:567764)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20463905;25253178;27220618", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I4B0;A0AC58I4B2;A0AC58I4B6;A0AC58I4B7;A0AC58I4C0;A0AC58I4C1;A0AC58I4C5;A0AC58I4C8;A0AC58I4C9;A0AC58I4D9", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6YUU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YV03-1", "uniprot_id": "A0A8M6YV03_DANRE", "mass": 82311.0, "length": 722, "protein_name": "Phospholipase A2", "gene_name": "pla2g4ab", "organism": "Zebrafish", "refseq_name": "cytosolic phospholipase A2 isoform X1", "refseq_ac": "XP_017208191", "gene_names_uniprotkb": "pla2g4ab", "gene_names_refseq": "pla2g4ab", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "cytosolic phospholipase A2 isoform X1", "tax_id": 7955, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (dre:559087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I5R1", "ec_number_list": "3.1.1.32;3.1.1.4;2.3.1.-;3.1.1.3;3.1.1.5", "go_molecular_function": "GO:0004620 phospholipase activity;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:2000045 regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YV03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YVC0-1", "uniprot_id": "A0A8M6YVC0_DANRE", "mass": 103989.0, "length": 904, "protein_name": "Dual specificity phosphatase 29", "gene_name": "LOC108179554", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X2", "refseq_ac": "XP_017206934", "gene_names_uniprotkb": "LOC108179554", "gene_names_refseq": "LOC108179554", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "uncharacterized protein isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:108179554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017206934.2. COMPLETENESS: full length., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of AMPK and MAPK1/2 signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YVC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YVP1-1", "uniprot_id": "A0A8M6YVP1_DANRE", "mass": 52667.0, "length": 457, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr175", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like isoform X1", "refseq_ac": "XP_017207210", "gene_names_uniprotkb": "pimr175", "gene_names_refseq": "pimr175", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017207210.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YVP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YWZ2-1", "uniprot_id": "A0A8M6YWZ2_DANRE", "mass": 43723.0, "length": 390, "protein_name": "5-hydroxytryptamine receptor 4", "gene_name": "si:dkey-247m21.3", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 4 isoform X1", "refseq_ac": "XP_017208337", "gene_names_uniprotkb": "si:dkey-247m21.3", "gene_names_refseq": "si:dkey-247m21.3", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 4; Serotonin receptor 4", "protein_names_refseq": "5-hydroxytryptamine receptor 4 isoform X1", "tax_id": 7955, "disease": "anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (dre:559089)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017208337.1. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IAR0;A0AC58IAR2;A0AC58IAR4", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0010008 endosome membrane", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0032098 regulation of appetite;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YWZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YYL8-1", "uniprot_id": "A0A8M6YYL8_DANRE", "mass": 44948.0, "length": 420, "protein_name": "CD44 antigen", "gene_name": "cd44b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein cd44b isoform X1", "refseq_ac": "XP_017209790", "gene_names_uniprotkb": "cd44b", "gene_names_refseq": "cd44b", "protein_names_uniprotkb": "CD44 antigen; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I", "protein_names_refseq": "uncharacterized protein cd44b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100330801)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017209790.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0048731 system development;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YYL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6YZP6-1", "uniprot_id": "A0A8M6YZP6_DANRE", "mass": 71841.0, "length": 634, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "srpk1a", "organism": "Zebrafish", "refseq_name": "SRSF protein kinase 1a isoform X1", "refseq_ac": "XP_017212769", "gene_names_uniprotkb": "srpk1a; srpk1; wu:fc06h03; zgc:63789", "gene_names_refseq": "srpk1a; srpk1; wu:fc06h03; zgc:63789", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "SRSF protein kinase 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017212769.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6YZP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z122-1", "uniprot_id": "A0A8M6Z122_DANRE", "mass": 20763.0, "length": 187, "protein_name": "diphosphoinositol-polyphosphate diphosphatase", "gene_name": "nudt3b", "organism": "Zebrafish", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 1 isoform X1", "refseq_ac": "XP_017211962", "gene_names_uniprotkb": "nudt3b; zgc:103443", "gene_names_refseq": "nudt3b; zgc:103443", "protein_names_uniprotkb": "diphosphoinositol-polyphosphate diphosphatase; 3.6.1.52", "protein_names_refseq": "diphosphoinositol polyphosphate phosphohydrolase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z131-1", "uniprot_id": "A0A8M6Z131_DANRE", "mass": 95234.0, "length": 838, "protein_name": "Discoidin domain-containing receptor 2", "gene_name": "ddr2b", "organism": "Zebrafish", "refseq_name": "discoidin domain-containing receptor 2 isoform X1", "refseq_ac": "XP_017206819", "gene_names_uniprotkb": "ddr2b", "gene_names_refseq": "ddr2b", "protein_names_uniprotkb": "Discoidin domain-containing receptor 2; 2.7.10.1; CD167 antigen-like family member B; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10", "protein_names_refseq": "discoidin domain-containing receptor 2 isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spondylometaepiphyseal dysplasia, short limb-hand type (Disease Ontology:DOID:0112196); stomach cancer (Disease Ontology:DOID:10534); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:559428)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017206819.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HAX1", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0038062 protein tyrosine kinase collagen receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001503 ossification;GO:0010715 regulation of extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z151-1", "uniprot_id": "A0A8M6Z151_DANRE", "mass": 123668.0, "length": 1114, "protein_name": "Glutamate receptor", "gene_name": "grin3bb", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, NMDA 3B isoform X1", "refseq_ac": "XP_017213803", "gene_names_uniprotkb": "grin3bb", "gene_names_refseq": "grin3bb", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 3B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100333101)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017213803.1. COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z1C5-1", "uniprot_id": "A0A8M6Z1C5_DANRE", "mass": 17722.0, "length": 159, "protein_name": "Molybdopterin synthase catalytic subunit", "gene_name": "mocs2", "organism": "Zebrafish", "refseq_name": "molybdopterin synthase catalytic subunit", "refseq_ac": "XP_021334934", "gene_names_uniprotkb": "mocs2; LOC103911725; MOCS2", "gene_names_refseq": "LOC103911725", "protein_names_uniprotkb": "Molybdopterin synthase catalytic subunit; 2.8.1.12; MOCS2B; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B", "protein_names_refseq": "molybdopterin synthase catalytic subunit", "tax_id": 7955, "disease": "molybdenum cofactor deficiency type B (Disease Ontology:DOID:0111163)", "pathway": " (dre:103911725); (dre:110437854)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin., [UniProtKB, HAMAP, UniProtKB]; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.1.12", "go_molecular_function": "GO:0030366 molybdopterin synthase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990140 molybdopterin synthase complex", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z1V6-1", "uniprot_id": "A0A8M6Z1V6_DANRE", "mass": 103838.0, "length": 904, "protein_name": "Dual specificity phosphatase 29", "gene_name": "LOC100333749", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_017206874", "gene_names_uniprotkb": "LOC100333749", "gene_names_refseq": "LOC100333749", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100333749)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017206874.2. COMPLETENESS: full length., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of AMPK and MAPK1/2 signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z1V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z2B4-1", "uniprot_id": "A0A8M6Z2B4_DANRE", "mass": 43060.0, "length": 382, "protein_name": "creatine kinase", "gene_name": "ckba", "organism": "Zebrafish", "refseq_name": "creatine kinase, brain a isoform X1", "refseq_ac": "XP_017214261", "gene_names_uniprotkb": "ckba; cb02h12; fb62d04; fc14g11; mg:cb02h12; wu:fb62d04; wu:fc14g11; zgc:154095; zgc:92079", "gene_names_refseq": "cb02h12; ckba; fb62d04; fc14g11; mg:cb02h12; wu:fb62d04; wu:fc14g11; zgc:154095; zgc:92079", "protein_names_uniprotkb": "creatine kinase; 2.7.3.2", "protein_names_refseq": "creatine kinase, brain a isoform X1", "tax_id": 7955, "disease": "left ventricular failure (Disease Ontology:DOID:0051064)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_017214261.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.3.2", "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z2I3-1", "uniprot_id": "A0A8M6Z2I3_DANRE", "mass": 56609.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr158", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2", "refseq_ac": "XP_017214431", "gene_names_uniprotkb": "pimr158", "gene_names_refseq": "pimr158", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2", "tax_id": 7955, "disease": "", "pathway": " (dre:798902)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017214431.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A628", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z2I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z303-1", "uniprot_id": "A0A8M6Z303_DANRE", "mass": 112880.0, "length": 1011, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "ephb1", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 1 isoform X1", "refseq_ac": "XP_017207747", "gene_names_uniprotkb": "ephb1", "gene_names_refseq": "ephb1", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "ephrin type-B receptor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100333537)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031901 early endosome membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0007155 cell adhesion;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z381-1", "uniprot_id": "A0A8M6Z381_DANRE", "mass": 277063.0, "length": 2447, "protein_name": "Voltage-dependent N-type calcium channel subunit alpha", "gene_name": "cacna1bb", "organism": "Zebrafish", "refseq_name": "voltage-dependent N-type calcium channel subunit alpha-1B isoform X1", "refseq_ac": "XP_017208482", "gene_names_uniprotkb": "cacna1bb", "gene_names_refseq": "cacna1bb", "protein_names_uniprotkb": "Voltage-dependent N-type calcium channel subunit alpha", "protein_names_refseq": "voltage-dependent N-type calcium channel subunit alpha-1B isoform X1", "tax_id": 7955, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); brain edema (Disease Ontology:DOID:4724); migraine (Disease Ontology:DOID:6364)", "pathway": " (dre:562796)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_017208482.2. COMPLETENESS: full length., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z3C8-1", "uniprot_id": "A0A8M6Z3C8_DANRE", "mass": 72350.0, "length": 643, "protein_name": "PR domain zinc finger protein 1", "gene_name": "prdm1c", "organism": "Zebrafish", "refseq_name": "PR domain zinc finger protein 1 isoform X1", "refseq_ac": "XP_017208061", "gene_names_uniprotkb": "prdm1c", "gene_names_refseq": "prdm1c", "protein_names_uniprotkb": "PR domain zinc finger protein 1; 2.1.1.-", "protein_names_refseq": "PR domain zinc finger protein 1 isoform X1", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:100150534)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I6D3;A0AC58I6D4;A0AC58I6E2;A0AC58I6E7;A0AC58I6F5;A0AC58I6F8", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z3C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z3Y2-1", "uniprot_id": "A0A8M6Z3Y2_DANRE", "mass": 135193.0, "length": 1203, "protein_name": "Adenylate cyclase type 6", "gene_name": "adcy6a", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 6 isoform X1", "refseq_ac": "XP_017209219", "gene_names_uniprotkb": "adcy6a", "gene_names_refseq": "adcy6a", "protein_names_uniprotkb": "Adenylate cyclase type 6; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 6 isoform X1", "tax_id": 7955, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (dre:570652); (R-DRE-163615); (R-DRE-170660); (R-DRE-170670); (R-DRE-400042); (R-DRE-418597); (R-DRE-5610787)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FEP5", "ec_number_list": "4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0022011 myelination in peripheral nervous system;GO:2000826 regulation of heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z3Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z421-1", "uniprot_id": "A0A8M6Z421_DANRE", "mass": 56639.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr154", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like", "refseq_ac": "XP_021336403", "gene_names_uniprotkb": "pimr154", "gene_names_refseq": "pimr154", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:799211)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QFL3", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z421-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z539-1", "uniprot_id": "A0A8M6Z539_DANRE", "mass": 230939.0, "length": 2005, "protein_name": "Myosin-11 isoform X1", "gene_name": "myh11b", "organism": "Zebrafish", "refseq_name": "myosin-11 isoform X1", "refseq_ac": "XP_017210292", "gene_names_uniprotkb": "myh11b", "gene_names_refseq": "myh11b", "protein_names_uniprotkb": "Myosin-11 isoform X1", "protein_names_refseq": "myosin-11 isoform X1", "tax_id": 7955, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (dre:566080)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0032982 myosin filament;GO:0016460 myosin II complex", "go_biological_process": "GO:0048731 system development;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z595-1", "uniprot_id": "A0A8M6Z595_DANRE", "mass": 44378.0, "length": 388, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "cdc25d", "organism": "Zebrafish", "refseq_name": "cell division cycle 25 homolog d isoform X1", "refseq_ac": "XP_017210413", "gene_names_uniprotkb": "cdc25d; si:ch211-202h22.3", "gene_names_refseq": "cdc25d; si:ch211-202h22.3", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "cell division cycle 25 homolog d isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z5Y9-1", "uniprot_id": "A0A8M6Z5Y9_DANRE", "mass": 85639.0, "length": 779, "protein_name": "Pendrin isoform X1", "gene_name": "slc26a4", "organism": "Zebrafish", "refseq_name": "pendrin", "refseq_ac": "NP_001428590", "gene_names_uniprotkb": "slc26a4; si:dkey-31f5.9", "gene_names_refseq": "si:dkey-31f5.9; slc26a4", "protein_names_uniprotkb": "Pendrin isoform X1", "protein_names_refseq": "anion exchanger SLC26A4; pendrin; solute carrier family 26 (anion exchanger), member 4", "tax_id": 7955, "disease": "Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); goiter (Disease Ontology:DOID:12176)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19641131", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01028254.1, GFIL01038436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715719, SAMN18715720 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jun 25, 2025 this sequence version replaced XP_068075774.1., [RefSeq]; Provide evidence that SLC26 anion transporters mediate branchial chloride uptake in adult zebrafish (Danio rerio)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055081 monoatomic anion homeostasis;GO:0006821 chloride transport;GO:0009651 response to salt stress;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M6Z5Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z658-1", "uniprot_id": "A0A8M6Z658_DANRE", "mass": 85362.0, "length": 757, "protein_name": "Semaphorin-3C", "gene_name": "sema3c", "organism": "Zebrafish", "refseq_name": "semaphorin-3C", "refseq_ac": "XP_017210807", "gene_names_uniprotkb": "sema3c", "gene_names_refseq": "sema3c", "protein_names_uniprotkb": "Semaphorin-3C", "protein_names_refseq": "semaphorin-3C", "tax_id": 7955, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:553130)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_017210807.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0048484 enteric nervous system development;GO:0035295 tube development;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z6P5-1", "uniprot_id": "A0A8M6Z6P5_DANRE", "mass": 119028.0, "length": 1041, "protein_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1", "gene_name": "farp1", "organism": "Zebrafish", "refseq_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X1", "refseq_ac": "XP_017211441", "gene_names_uniprotkb": "farp1", "gene_names_refseq": "farp1", "protein_names_uniprotkb": "FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF and pleckstrin domain-containing protein 1", "protein_names_refseq": "FERM, ARHGEF and pleckstrin domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100329707)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008092 cytoskeletal protein binding;GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0030175 filopodium", "go_biological_process": "GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z6P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z6P7-1", "uniprot_id": "A0A8M6Z6P7_DANRE", "mass": 86753.0, "length": 772, "protein_name": "Protein transport protein SEC23", "gene_name": "sec23b", "organism": "Zebrafish", "refseq_name": "protein transport protein Sec23B isoform X1", "refseq_ac": "XP_017211933", "gene_names_uniprotkb": "sec23b; fl08h02; wu:fd19h01; wu:fl08h02; zgc:55595; zgc:86871", "gene_names_refseq": "fl08h02; sec23b; wu:fd19h01; wu:fl08h02; zgc:55595; zgc:86871", "protein_names_uniprotkb": "Protein transport protein SEC23", "protein_names_refseq": "protein transport protein Sec23B isoform X1", "tax_id": 7955, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); Cowden syndrome 7 (Disease Ontology:DOID:0081003); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0051216 cartilage development;GO:0048821 erythrocyte development;GO:0048702 embryonic neurocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z6P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z7B1-1", "uniprot_id": "A0A8M6Z7B1_DANRE", "mass": 36232.0, "length": 324, "protein_name": "Zinc finger Ran-binding domain-containing protein 2", "gene_name": "zranb2", "organism": "Zebrafish", "refseq_name": "zinc finger Ran-binding domain-containing protein 2 isoform X1", "refseq_ac": "XP_017211949", "gene_names_uniprotkb": "zranb2; wu:fa96h03; zgc:56597", "gene_names_refseq": "wu:fa96h03; zgc:56597; zranb2", "protein_names_uniprotkb": "Zinc finger Ran-binding domain-containing protein 2", "protein_names_refseq": "zinc finger Ran-binding domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:406716)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;26740623;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May interfere with constitutive 5'-splice site selection., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001530 lipopolysaccharide binding;GO:0030882 lipid antigen binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006396 RNA processing;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M6Z7B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z7R4-1", "uniprot_id": "A0A8M6Z7R4_DANRE", "mass": 60482.0, "length": 543, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "si:ch211-285c6.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch211-285c6.3 isoform X1", "refseq_ac": "XP_017212428", "gene_names_uniprotkb": "si:ch211-285c6.3", "gene_names_refseq": "si:ch211-285c6.3", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein si:ch211-285c6.3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G2P0;F1QCQ0", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z7R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M6Z942-1", "uniprot_id": "A0A8M6Z942_DANRE", "mass": 125952.0, "length": 1115, "protein_name": "Transient receptor potential cation channel subfamily A member 1", "gene_name": "trpa1a", "organism": "Zebrafish", "refseq_name": "transient receptor potential cation channel subfamily A member 1a isoform X2", "refseq_ac": "XP_017213756", "gene_names_uniprotkb": "trpa1a; ANKTM1; trpa1", "gene_names_refseq": "ANKTM1; trpa1a; trpa1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1", "protein_names_refseq": "transient receptor potential cation channel subfamily A member 1a isoform X2", "tax_id": 7955, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); familial episodic pain syndrome 1 (Disease Ontology:DOID:0111729); asthma (Disease Ontology:DOID:2841); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:474351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0015278 intracellularly gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009593 detection of chemical stimulus;GO:0034220 monoatomic ion transmembrane transport;GO:0009266 response to temperature stimulus;GO:0033554 cellular response to stress;GO:0050974 detection of mechanical stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M6Z942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PD70-1", "uniprot_id": "OXR1A_DANRE", "mass": 90153.0, "length": 804, "protein_name": "Oxidation resistance protein 1A", "gene_name": "oxr1a", "organism": "Zebrafish", "refseq_name": "oxidation resistance protein 1a isoform X1", "refseq_ac": "XP_021322409", "gene_names_uniprotkb": "oxr1a; fb25h12; oxr1; oxr2; wu:fb25h12; zgc:175266", "gene_names_refseq": "fb25h12; oxr1a; oxr1; oxr2; wu:fb25h12; zgc:175266", "protein_names_uniprotkb": "Oxidation resistance protein 1A", "protein_names_refseq": "oxidation resistance protein 1a isoform X1", "tax_id": 7955, "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)", "pathway": " (dre:571418)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22434723;23594743;32987694;37031846", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage (PubMed:32987694, PubMed:37031846). Required for female fertility through its role in protection of oocytes against oxidative stress (PubMed:37031846)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; May be involved in protection from oxidative damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9JTH8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:1902882 regulation of response to oxidative stress;GO:1900193 regulation of oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M9PD70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9NZM6-1", "uniprot_id": "A0A8M9NZM6_DANRE", "mass": 58700.0, "length": 522, "protein_name": "Steroid 21-hydroxylase", "gene_name": "cyp21a2", "organism": "Zebrafish", "refseq_name": "steroid 21-hydroxylase", "refseq_ac": "XP_021330030", "gene_names_uniprotkb": "cyp21a2", "gene_names_refseq": "cyp21a2", "protein_names_uniprotkb": "Steroid 21-hydroxylase; 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21", "protein_names_refseq": "steroid 21-hydroxylase", "tax_id": 7955, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811)", "pathway": " (dre:793249); (R-DRE-193993); (R-DRE-194002); (R-DRE-211976)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q0C9", "ec_number_list": "1.14.14.16", "go_molecular_function": "GO:0005506 iron ion binding;GO:0005496 steroid binding;GO:0020037 heme binding;GO:0004509 steroid 21-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006704 glucocorticoid biosynthetic process;GO:0120178 steroid hormone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9NZM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P0R6-1", "uniprot_id": "A0A8M9P0R6_DANRE", "mass": 201557.0, "length": 1773, "protein_name": "Otoferlin", "gene_name": "otofb", "organism": "Zebrafish", "refseq_name": "otoferlin b isoform 2", "refseq_ac": "NP_001429298", "gene_names_uniprotkb": "otofb", "gene_names_refseq": "otofb; si:ch73-50f9.1", "protein_names_uniprotkb": "Otoferlin; Fer-1-like protein 2", "protein_names_refseq": "otoferlin b isoform 2", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 9 (Disease Ontology:DOID:0110535)", "pathway": " (dre:100331283)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31582816", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.19833600.1, SRR32588718.7687542.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 4, 2025 this sequence version replaced XP_021323162.1., [RefSeq]; Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HP29", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005509 calcium ion binding;GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0050885 neuromuscular process controlling balance;GO:0010996 response to auditory stimulus;GO:0036269 swimming behavior;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M9P0R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P2C9-1", "uniprot_id": "A0A8M9P2C9_DANRE", "mass": 47691.0, "length": 418, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr81", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pimr81", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:100034392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P2C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P2Q2-1", "uniprot_id": "A0A8M9P2Q2_DANRE", "mass": 201791.0, "length": 1789, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "cdc42bpb", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase MRCK beta isoform X1", "refseq_ac": "XP_021324167", "gene_names_uniprotkb": "cdc42bpb; si:dkeyp-93h6.2; wu:fb98c02; wu:fc48b05; wu:fc90d12", "gene_names_refseq": "cdc42bpb; si:dkeyp-93h6.2; wu:fb98c02; wu:fc48b05; wu:fc90d12", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase MRCK beta isoform X1", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); azoospermia (Disease Ontology:DOID:14227)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324167.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P2Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P366-1", "uniprot_id": "A0A8M9P366_DANRE", "mass": 81524.0, "length": 738, "protein_name": "Gelsolin", "gene_name": "gsna", "organism": "Zebrafish", "refseq_name": "gelsolin a isoform X1", "refseq_ac": "XP_021324427", "gene_names_uniprotkb": "gsna; cb107; gsn; sb:cb107; u-gelsolin; wu:fi16f06", "gene_names_refseq": "cb107; gsna; gsn; sb:cb107; u-gelsolin; wu:fi16f06", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor", "protein_names_refseq": "gelsolin a isoform X1", "tax_id": 7955, "disease": "Finnish type amyloidosis (Disease Ontology:DOID:0050637); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); rheumatic myocarditis (Disease Ontology:DOID:8481); lung disease (Disease Ontology:DOID:850); gas gangrene (Disease Ontology:DOID:9159)", "pathway": " (dre:321099)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10564357;15520368;15642334;16373575;17548429;28252024;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324427.1. COMPLETENESS: full length., [RefSeq]; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0060271 cilium assembly;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9P366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P4U0-1", "uniprot_id": "A0A8M9P4U0_DANRE", "mass": 49174.0, "length": 442, "protein_name": "STE20-related kinase adapter protein alpha", "gene_name": "strada", "organism": "Zebrafish", "refseq_name": "STE20-related kinase adapter protein alpha isoform X1", "refseq_ac": "XP_021325312", "gene_names_uniprotkb": "strada; fj99g05; wu:fj99g05; zgc:56109", "gene_names_refseq": "fj99g05; strada; wu:fj99g05; zgc:56109", "protein_names_uniprotkb": "STE20-related kinase adapter protein alpha; STE20-related adapter protein", "protein_names_refseq": "STE20-related kinase adapter protein alpha isoform X1", "tax_id": 7955, "disease": "polyhydramnios, megalencephaly, and symptomatic epilepsy (Disease Ontology:DOID:0070511); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:334550)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;34083748", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IF98;A0AC58IFA2", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016301 kinase activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9P4U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P515-1", "uniprot_id": "A0A8M9P515_DANRE", "mass": 70053.0, "length": 642, "protein_name": "Sodium-dependent phosphate transport protein 2B", "gene_name": "slc34a2b", "organism": "Zebrafish", "refseq_name": "solute carrier family 34 member 2b isoform X1", "refseq_ac": "XP_021325432", "gene_names_uniprotkb": "slc34a2b; NaPi-IIb2; wu:fi68d06", "gene_names_refseq": "NaPi-IIb2; slc34a2b; wu:fi68d06", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B; Solute carrier family 34 member 2", "protein_names_refseq": "solute carrier family 34 member 2b isoform X1", "tax_id": 7955, "disease": "pulmonary alveolar microlithiasis (Disease Ontology:DOID:12117)", "pathway": " (dre:359838); (R-DRE-427589); (R-DRE-5683826)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16109975;18413783;26469318;27189481;27784684;28542524;35134499", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in actively transporting phosphate into cells via Na(+) cotransport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0005903 brush border;GO:0031982 vesicle", "go_biological_process": "GO:0006817 phosphate ion transport;GO:0044341 sodium-dependent phosphate transport;GO:0030643 intracellular phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M9P515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P5C7-1", "uniprot_id": "A0A8M9P5C7_DANRE", "mass": 44384.0, "length": 393, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "si:ch211-220i18.4", "organism": "Zebrafish", "refseq_name": "SRSF protein kinase 3", "refseq_ac": "XP_021325577", "gene_names_uniprotkb": "si:ch211-220i18.4", "gene_names_refseq": "si:ch211-220i18.4", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "SRSF protein kinase 3", "tax_id": 7955, "disease": "", "pathway": " (dre:798392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021325577.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000245 spliceosomal complex assembly;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P5C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P799-1", "uniprot_id": "A0A8M9P799_DANRE", "mass": 108092.0, "length": 965, "protein_name": "Glutamate receptor", "gene_name": "grik4", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 4", "refseq_ac": "XP_021322088", "gene_names_uniprotkb": "grik4", "gene_names_refseq": "grik4", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 4", "tax_id": 7955, "disease": "", "pathway": " (dre:556582)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HCR4;A0AC58HCR8;A0AC58HCR9;A0AC58HCS2;A0AC58HCS4;A0AC58HCU6;A0AC58HCV5", "ec_number_list": "", "go_molecular_function": "GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P9F6-1", "uniprot_id": "A0A8M9P9F6_DANRE", "mass": 125068.0, "length": 1118, "protein_name": "Glutamate receptor", "gene_name": "grin3ba", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, NMDA 3B", "refseq_ac": "XP_021323058", "gene_names_uniprotkb": "grin3ba", "gene_names_refseq": "grin3ba", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 3B", "tax_id": 7955, "disease": "", "pathway": " (dre:566411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P9F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P9J4-1", "uniprot_id": "A0A8M9P9J4_DANRE", "mass": 75702.0, "length": 655, "protein_name": "Matrix metalloproteinase-15", "gene_name": "mmp15b", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-15", "refseq_ac": "XP_021323108", "gene_names_uniprotkb": "mmp15b", "gene_names_refseq": "mmp15b", "protein_names_uniprotkb": "Matrix metalloproteinase-15", "protein_names_refseq": "matrix metalloproteinase-15", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); transitional cell carcinoma (Disease Ontology:DOID:2671)", "pathway": " (dre:100332426)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P9J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PD49-1", "uniprot_id": "A0A8M9PD49_DANRE", "mass": 127086.0, "length": 1146, "protein_name": "Cytospin-A", "gene_name": "specc1lb", "organism": "Zebrafish", "refseq_name": "cytospin-A isoform X1", "refseq_ac": "XP_021324703", "gene_names_uniprotkb": "specc1lb", "gene_names_refseq": "specc1lb", "protein_names_uniprotkb": "Cytospin-A", "protein_names_refseq": "cytospin-A isoform X1", "tax_id": 7955, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); Teebi hypertelorism syndrome 1 (Disease Ontology:DOID:0080698); oblique facial clefting 1 (Disease Ontology:DOID:0111706); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dre:555467)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005815 microtubule organizing center;GO:0031941 filamentous actin;GO:0005921 gap junction", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0051301 cell division;GO:0030036 actin cytoskeleton organization;GO:0097095 frontonasal suture morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PD49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PD63-1", "uniprot_id": "A0A8M9PD63_DANRE", "mass": 68408.0, "length": 591, "protein_name": "E3 ubiquitin-protein ligase CBL", "gene_name": "cblc", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase CBL-C isoform X1", "refseq_ac": "XP_005158183", "gene_names_uniprotkb": "cblc; si:ch211-175g6.9; zgc:172162", "gene_names_refseq": "cblc; si:ch211-175g6.9; zgc:172162", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase CBL-C isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565383)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12477932;21873635;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0016567 protein ubiquitination;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0023051 regulation of signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PD63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PD73-1", "uniprot_id": "A0A8M9PD73_DANRE", "mass": 52288.0, "length": 466, "protein_name": "Cyclin-dependent kinase 14", "gene_name": "cdk14", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 14 isoform 1", "refseq_ac": "NP_001417827", "gene_names_uniprotkb": "cdk14; zgc:172096", "gene_names_refseq": "cdk14; zgc:172096", "protein_names_uniprotkb": "Cyclin-dependent kinase 14; 2.7.11.22; Cell division protein kinase 14", "protein_names_refseq": "cyclin-dependent kinase 14 isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:572146)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25151948;26469318;27189481;28252024;36748120", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.24308844.1, SRR26395013.552001.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Jul 21, 2025 this sequence version replaced XP_073781367.1, XP_021322414.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HHA9", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0016055 Wnt signaling pathway;GO:1901987 regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M9PD73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PDN7-1", "uniprot_id": "A0A8M9PDN7_DANRE", "mass": 64274.0, "length": 587, "protein_name": "Sodium-dependent phosphate transport protein 2A", "gene_name": "slc34a1b", "organism": "Zebrafish", "refseq_name": "sodium-dependent phosphate transport protein 2A isoform X1", "refseq_ac": "XP_021324923", "gene_names_uniprotkb": "slc34a1b", "gene_names_refseq": "slc34a1b", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; Sodium/phosphate cotransporter 2A; Solute carrier family 34 member 1", "protein_names_refseq": "sodium-dependent phosphate transport protein 2A isoform X1", "tax_id": 7955, "disease": "hypophosphatemia (Disease Ontology:DOID:0050336); hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947); infantile hypercalcemia 2 (Disease Ontology:DOID:0061135); hypophosphatemic nephrolithiasis/osteoporosis 1 (Disease Ontology:DOID:0080077); Fanconi renotubular syndrome 2 (Disease Ontology:DOID:0080758); Fanconi syndrome (Disease Ontology:DOID:1062); hypothyroidism (Disease Ontology:DOID:1459); nephrolithiasis (Disease Ontology:DOID:585); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:565599)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021324923.1. COMPLETENESS: full length., [RefSeq]; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PDN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PEX6-1", "uniprot_id": "A0A8M9PEX6_DANRE", "mass": 52235.0, "length": 468, "protein_name": "Hepatocyte nuclear factor 4-alpha isoform X3", "gene_name": "hnf4a", "organism": "Zebrafish", "refseq_name": "hepatocyte nuclear factor 4-alpha isoform X3", "refseq_ac": "XP_021325423", "gene_names_uniprotkb": "hnf4a; fb58h09; id:ibd1279; sb:eu665; wu:fb58h09", "gene_names_refseq": "fb58h09; hnf4a; id:ibd1279; sb:eu665; wu:fb58h09", "protein_names_uniprotkb": "Hepatocyte nuclear factor 4-alpha isoform X3", "protein_names_refseq": "hepatocyte nuclear factor 4-alpha isoform X3", "tax_id": 7955, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); Fanconi renotubular syndrome 4 (Disease Ontology:DOID:0080760); maturity-onset diabetes of the young type 1 (Disease Ontology:DOID:0111099); Fanconi syndrome (Disease Ontology:DOID:1062); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcohol use disorder (Disease Ontology:DOID:1574); glaucoma (Disease Ontology:DOID:1686); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021325423.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PEX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PGG2-1", "uniprot_id": "A0A8M9PGG2_DANRE", "mass": 119330.0, "length": 1042, "protein_name": "Phospholipase", "gene_name": "pld1b", "organism": "Zebrafish", "refseq_name": "phospholipase D1", "refseq_ac": "XP_021326023", "gene_names_uniprotkb": "pld1b", "gene_names_refseq": "pld1b", "protein_names_uniprotkb": "Phospholipase; 3.1.4.4", "protein_names_refseq": "phospholipase D1", "tax_id": 7955, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (dre:572492)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.4;3.1.4.39", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PGG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PGY1-1", "uniprot_id": "A0A8M9PGY1_DANRE", "mass": 36932.0, "length": 321, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1", "gene_name": "st3gal1", "organism": "Zebrafish", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1 isoform X1", "refseq_ac": "XP_021323934", "gene_names_uniprotkb": "st3gal1", "gene_names_refseq": "st3gal1", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; 2.4.3.4; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; ST3Gal I; ST3GalA.1; ST3O; Sialyltransferase 4A", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:553279)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021323934.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.2;2.4.3.4", "go_molecular_function": "GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PGY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PHB7-1", "uniprot_id": "A0A8M9PHB7_DANRE", "mass": 90744.0, "length": 798, "protein_name": "ATP-dependent DNA helicase", "gene_name": "recql", "organism": "Zebrafish", "refseq_name": "ATP-dependent DNA helicase Q1 isoform X1", "refseq_ac": "XP_005164818", "gene_names_uniprotkb": "recql; zgc:110631", "gene_names_refseq": "recql; zgc:110631", "protein_names_uniprotkb": "ATP-dependent DNA helicase; 5.6.2.4", "protein_names_refseq": "ATP-dependent DNA helicase Q1 isoform X1", "tax_id": 7955, "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J7R9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PHB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PHR9-1", "uniprot_id": "A0A8M9PHR9_DANRE", "mass": 297889.0, "length": 2773, "protein_name": "Filamin-C isoform X1", "gene_name": "flncb", "organism": "Zebrafish", "refseq_name": "filamin-C isoform X1", "refseq_ac": "XP_009298480", "gene_names_uniprotkb": "flncb", "gene_names_refseq": "flncb", "protein_names_uniprotkb": "Filamin-C isoform X1", "protein_names_refseq": "filamin-C isoform X1", "tax_id": 7955, "disease": "myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); hypertrophic cardiomyopathy 26 (Disease Ontology:DOID:0110327); distal myopathy 4 (Disease Ontology:DOID:0111190); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:570288); (R-DRE-446353)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J9J5;F1QL44", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007399 nervous system development;GO:0030036 actin cytoskeleton organization;GO:0048742 regulation of skeletal muscle fiber development;GO:0007507 heart development;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PHR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PIE9-1", "uniprot_id": "A0A8M9PIE9_DANRE", "mass": 46001.0, "length": 409, "protein_name": "Ferrochelatase", "gene_name": "fech", "organism": "Zebrafish", "refseq_name": "ferrochelatase, mitochondrial isoform X1", "refseq_ac": "XP_021324574", "gene_names_uniprotkb": "fech; fch; zgc:109851", "gene_names_refseq": "fch; fech; zgc:109851", "protein_names_uniprotkb": "Ferrochelatase; 4.98.1.1", "protein_names_refseq": "ferrochelatase, mitochondrial isoform X1", "tax_id": 7955, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (dre:58215)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IA06", "ec_number_list": "4.98.1.1", "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004325 ferrochelatase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PIE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PIU0-1", "uniprot_id": "A0A8M9PIU0_DANRE", "mass": 93902.0, "length": 835, "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "fbxw7", "organism": "Zebrafish", "refseq_name": "F-box/WD repeat-containing protein 7 isoform X1", "refseq_ac": "XP_021329580", "gene_names_uniprotkb": "fbxw7", "gene_names_refseq": "fbxw7", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 7", "protein_names_refseq": "F-box/WD repeat-containing protein 7 isoform X1", "tax_id": 7955, "disease": "developmental delay, hypotonia, and impaired language (Disease Ontology:DOID:0070420)", "pathway": " (dre:564991)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0042752 regulation of circadian rhythm;GO:0000209 protein polyubiquitination;GO:0031641 regulation of myelination;GO:0032006 regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PIU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PJE4-1", "uniprot_id": "A0A8M9PJE4_DANRE", "mass": 48901.0, "length": 441, "protein_name": "Iroquois-class homeodomain protein IRX-4a isoform X1", "gene_name": "irx4a", "organism": "Zebrafish", "refseq_name": "iroquois-class homeodomain protein IRX-4a isoform X1", "refseq_ac": "XP_021322341", "gene_names_uniprotkb": "irx4a; zgc:77362; ziro4a", "gene_names_refseq": "irx4a; zgc:77362; ziro4a", "protein_names_uniprotkb": "Iroquois-class homeodomain protein IRX-4a isoform X1", "protein_names_refseq": "iroquois-class homeodomain protein IRX-4a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0042461 photoreceptor cell development;GO:0048468 cell development;GO:0048923 posterior lateral line neuromast hair cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PJE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PK29-1", "uniprot_id": "A0A8M9PK29_DANRE", "mass": 117898.0, "length": 1059, "protein_name": "Integrin alpha-8", "gene_name": "itga8", "organism": "Zebrafish", "refseq_name": "integrin alpha-8", "refseq_ac": "XP_021322596", "gene_names_uniprotkb": "itga8", "gene_names_refseq": "itga8", "protein_names_uniprotkb": "Integrin alpha-8", "protein_names_refseq": "integrin alpha-8", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059); renal agenesis (Disease Ontology:DOID:14766); ovarian cancer (Disease Ontology:DOID:2394); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); schizophrenia (Disease Ontology:DOID:5419); end stage renal disease (Disease Ontology:DOID:783); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dre:100141346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion;GO:0060271 cilium assembly;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PK29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q5B7-1", "uniprot_id": "F1Q5B7_DANRE", "mass": 39517.0, "length": 353, "protein_name": "Protein Wnt", "gene_name": "wnt7ba", "organism": "Zebrafish", "refseq_name": "protein Wnt-7b isoform X2", "refseq_ac": "XP_691878", "gene_names_uniprotkb": "wnt7ba", "gene_names_refseq": "wnt7ba", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-7b isoform X2", "tax_id": 7955, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); breast fibroadenoma (Disease Ontology:DOID:1618)", "pathway": " (dre:563427)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_691878.1. COMPLETENESS: full length., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TDZ7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0048731 system development;GO:0030154 cell differentiation;GO:0016055 Wnt signaling pathway;GO:0009888 tissue development;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1Q5B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PSF7-1", "uniprot_id": "A0A8M9PSF7_DANRE", "mass": 86998.0, "length": 799, "protein_name": "Gephyrin", "gene_name": "gphnb", "organism": "Zebrafish", "refseq_name": "gephyrin b isoform X1", "refseq_ac": "XP_021324010", "gene_names_uniprotkb": "gphnb; fj59a01; gphn2; wu:fj59a01", "gene_names_refseq": "fj59a01; gphn2; gphnb; wu:fj59a01", "protein_names_uniprotkb": "Gephyrin; 2.10.1.1; 2.7.7.75", "protein_names_refseq": "gephyrin b isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); molybdenum cofactor deficiency type C (Disease Ontology:DOID:0111166); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.10.1.1;2.7.7.75", "go_molecular_function": "GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0072579 glycine receptor clustering;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0042330 taxis;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PSF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QFV1-1", "uniprot_id": "E9QFV1_DANRE", "mass": 24784.0, "length": 222, "protein_name": "Gal_Lectin domain-containing protein precursor", "gene_name": "ddx41", "organism": "Zebrafish", "refseq_name": "Gal_Lectin domain-containing protein precursor", "refseq_ac": "NP_001315125", "gene_names_uniprotkb": "ddx41; si:ch1073-75o15.3", "gene_names_refseq": "si:ch1073-75o15.3", "protein_names_uniprotkb": "Gal_Lectin domain-containing protein precursor", "protein_names_refseq": "Gal_Lectin domain-containing protein precursor; L-rhamnose-binding lectin-like", "tax_id": 7955, "disease": "myeloproliferative neoplasm (Disease Ontology:DOID:2226)", "pathway": " (dre:108004520)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH489429.1 and EH515790.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8W6", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0009615 response to virus;GO:0048823 nucleate erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9QFV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q3D0-1", "uniprot_id": "A0A8M9Q3D0_DANRE", "mass": 132110.0, "length": 1186, "protein_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase", "gene_name": "mtmr3", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform X1", "refseq_ac": "XP_021333893", "gene_names_uniprotkb": "mtmr3; si:ch73-100n10.1; si:ch73-100n10.2; zgc:77875", "gene_names_refseq": "mtmr3; si:ch73-100n10.1; si:ch73-100n10.2; zgc:77875", "protein_names_uniprotkb": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform X1", "tax_id": 7955, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (dre:393838)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21925157;27806088", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021333893.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0046474 glycerophospholipid biosynthetic process;GO:0046856 phosphatidylinositol dephosphorylation;GO:0061952 midbody abscission;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9Q3D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXR5-1", "uniprot_id": "A0A8M9PXR5_DANRE", "mass": 125953.0, "length": 1118, "protein_name": "Activated CDC42 kinase 1", "gene_name": "tnk2b", "organism": "Zebrafish", "refseq_name": "tyrosine kinase, non-receptor, 2b isoform X1", "refseq_ac": "XP_021336227", "gene_names_uniprotkb": "tnk2b; ackb; si:ch73-329g8.1; tnk2", "gene_names_refseq": "ackb; si:ch73-329g8.1; tnk2b; tnk2", "protein_names_uniprotkb": "Activated CDC42 kinase 1; 2.7.10.2; 2.7.11.1; Tyrosine kinase non-receptor protein 2", "protein_names_refseq": "tyrosine kinase, non-receptor, 2b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559119)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23234507;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M9PXR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQC3-1", "uniprot_id": "A0A8M9PQC3_DANRE", "mass": 208038.0, "length": 1817, "protein_name": "Chromodomain-helicase-DNA-binding protein 2 isoform X1", "gene_name": "chd2", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 2 isoform X1", "refseq_ac": "XP_021323365", "gene_names_uniprotkb": "chd2; si:ch211-196l7.5", "gene_names_refseq": "chd2; si:ch211-196l7.5", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 2 isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 2 isoform X1", "tax_id": 7955, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); developmental and epileptic encephalopathy 94 (Disease Ontology:DOID:0081325); prostate cancer (Disease Ontology:DOID:10283); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:569795)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19478994;24207121;24240475;26469318;27418670;32756943;34083748;39021799;39180515", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003678 DNA helicase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0040011 locomotion;GO:0043009 chordate embryonic development;GO:0099610 action potential initiation;GO:0034728 nucleosome organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9PQC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PPK1-1", "uniprot_id": "A0A8M9PPK1_DANRE", "mass": 50014.0, "length": 447, "protein_name": "Squalene synthase", "gene_name": "fdft1", "organism": "Zebrafish", "refseq_name": "squalene synthase isoform X1", "refseq_ac": "XP_021324186", "gene_names_uniprotkb": "fdft1; si:ch73-107c13.2", "gene_names_refseq": "fdft1; si:ch73-107c13.2", "protein_names_uniprotkb": "Squalene synthase; 2.5.1.21; SQS; SS", "protein_names_refseq": "squalene synthase isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:571911)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21538441;25483594;25938946;26912795;27189481;30373040;31677519;33523501;37119330", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.21", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051996 squalene synthase [NAD(P)H] activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0045338 farnesyl diphosphate metabolic process;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9PPK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PSK8-1", "uniprot_id": "A0A8M9PSK8_DANRE", "mass": 62018.0, "length": 563, "protein_name": "Centrosomal protein 43", "gene_name": "cep43", "organism": "Zebrafish", "refseq_name": "centrosomal protein 43 isoform X1", "refseq_ac": "XP_021324065", "gene_names_uniprotkb": "cep43; ccr6a; fgfr1op; zgc:86782", "gene_names_refseq": "ccr6a; cep43; fgfr1op; zgc:86782", "protein_names_uniprotkb": "Centrosomal protein 43; FGFR1 oncogene partner", "protein_names_refseq": "centrosomal protein 43 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for anchoring microtubules to the centrosomes. Required for ciliation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0030030 cell projection organization;GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PSK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q2N7-1", "uniprot_id": "A0A8M9Q2N7_DANRE", "mass": 144789.0, "length": 1294, "protein_name": "Diacylglycerol kinase", "gene_name": "dgkza", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase zeta isoform X1", "refseq_ac": "XP_021333603", "gene_names_uniprotkb": "dgkza", "gene_names_refseq": "dgkza", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase zeta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:553380)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G587", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity;GO:0047649 alkylglycerol kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process;GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q2N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PLW9-1", "uniprot_id": "A0A8M9PLW9_DANRE", "mass": 53509.0, "length": 474, "protein_name": "Friend leukemia integration 1 transcription factor isoform X1", "gene_name": "fli1", "organism": "Zebrafish", "refseq_name": "Friend leukemia integration 1 transcription factor isoform X1", "refseq_ac": "XP_021323256", "gene_names_uniprotkb": "fli1; cb855; fli-1; fli1a; fli; wu:fc45b11", "gene_names_refseq": "cb855; fli-1; fli1a; fli1; fli; wu:fc45b11", "protein_names_uniprotkb": "Friend leukemia integration 1 transcription factor isoform X1", "protein_names_refseq": "Friend leukemia integration 1 transcription factor isoform X1", "tax_id": 7955, "disease": "thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (dre:30619)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10357891;10710309;11119306;12050147;12086862;38526188;38646676;39101673;39271818;39521779", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PLW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PM31-1", "uniprot_id": "A0A8M9PM31_DANRE", "mass": 77346.0, "length": 679, "protein_name": "Protein kinase C", "gene_name": "prkcaa", "organism": "Zebrafish", "refseq_name": "protein kinase C, alpha, a isoform X1", "refseq_ac": "XP_021332537", "gene_names_uniprotkb": "prkcaa; im:7139045; prkca; si:dkey-8l19.1", "gene_names_refseq": "im:7139045; prkcaa; prkca; si:dkey-8l19.1", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C, alpha, a isoform X1", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); chordoid glioma (Disease Ontology:DOID:3774); ovarian carcinoma (Disease Ontology:DOID:4001); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:497384); (R-DRE-111933); (R-DRE-114516); (R-DRE-1433557); (R-DRE-1433559); (R-DRE-2179392); (R-DRE-3000170); (R-DRE-399997); (R-DRE-416993); (R-DRE-4419969); (R-DRE-450520); (R-DRE-5099900); (R-DRE-5218921); (R-DRE-5668599); (R-DRE-76005); (R-DRE-8853659)", "pathway_count": 16, "publication_count": 10, "publication_id_list": "17403595;19261700;19366675;20692251;20943708;32322295;33036185;34329618;36835261;39452847", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.11.-;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;3.4.24.7", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PM31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXN3-1", "uniprot_id": "A0A8M9PXN3_DANRE", "mass": 83218.0, "length": 746, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark3a", "organism": "Zebrafish", "refseq_name": "MAP/microtubule affinity-regulating kinase 3a isoform X1", "refseq_ac": "XP_021336197", "gene_names_uniprotkb": "mark3a; fi39g08; mark3; wu:fi39g08; zgc:152848; zgc:55693", "gene_names_refseq": "fi39g08; mark3a; mark3; wu:fi39g08; zgc:152848; zgc:55693", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 3a isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PXN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PRM2-1", "uniprot_id": "A0A8M9PRM2_DANRE", "mass": 219128.0, "length": 1931, "protein_name": "Chromodomain-helicase-DNA-binding protein 4a isoform X1", "gene_name": "chd4a", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 4a isoform X1", "refseq_ac": "XP_021323760", "gene_names_uniprotkb": "chd4a; im:7143343; si:ch211-51m24.3", "gene_names_refseq": "chd4a; im:7143343; si:ch211-51m24.3", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 4a isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 4a isoform X1", "tax_id": 7955, "disease": "lymphoma (Disease Ontology:DOID:0060058); left ventricular noncompaction (Disease Ontology:DOID:0060480); Sifrim-Hitz-Weiss syndrome (Disease Ontology:DOID:0070529); lung cancer (Disease Ontology:DOID:1324); rectum cancer (Disease Ontology:DOID:1993); colon adenocarcinoma (Disease Ontology:DOID:234); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:558344)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "22814267;24240475;24779377;26092436;27418670;31594822;32004993;39021799;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0016581 NuRD complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8M9PRM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q0N4-1", "uniprot_id": "A0A8M9Q0N4_DANRE", "mass": 84042.0, "length": 763, "protein_name": "Transcription factor SOX-5 isoform X1", "gene_name": "sox5", "organism": "Zebrafish", "refseq_name": "transcription factor SOX-5 isoform X1", "refseq_ac": "XP_021330769", "gene_names_uniprotkb": "sox5; id:ibd5067; sb:eu456; si:dkey-215a8.1", "gene_names_refseq": "id:ibd5067; sb:eu456; si:dkey-215a8.1; sox5", "protein_names_uniprotkb": "Transcription factor SOX-5 isoform X1", "protein_names_refseq": "transcription factor SOX-5 isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030318 melanocyte differentiation;GO:0050935 iridophore differentiation;GO:0050936 xanthophore differentiation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q0N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q3C1-1", "uniprot_id": "A0A8M9Q3C1_DANRE", "mass": 225367.0, "length": 1984, "protein_name": "Transcription initiation factor TFIID subunit", "gene_name": "taf1", "organism": "Zebrafish", "refseq_name": "transcription initiation factor TFIID subunit 1 isoform X1", "refseq_ac": "XP_021331844", "gene_names_uniprotkb": "taf1; wu:fi04f03; wu:fy39f07", "gene_names_refseq": "taf1; wu:fi04f03; wu:fy39f07", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit", "protein_names_refseq": "transcription initiation factor TFIID subunit 1 isoform X1", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); X-linked dystonia-parkinsonism (Disease Ontology:DOID:0090057)", "pathway": " (dre:555452)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;20034391;24240475;25995187;26469318;31341187;33271625;37746814;38656129;39021799", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0017025 TBP-class protein binding;GO:0004402 histone acetyltransferase activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0048589 developmental growth;GO:0006352 DNA-templated transcription initiation;GO:0030901 midbrain development;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9Q3C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQY4-1", "uniprot_id": "A0A8M9PQY4_DANRE", "mass": 203783.0, "length": 1993, "protein_name": "Host cell factor 1", "gene_name": "hcfc1b", "organism": "Zebrafish", "refseq_name": "host cell factor 1b", "refseq_ac": "NP_001122009", "gene_names_uniprotkb": "hcfc1b; fc07b09; fe17f08; wu:fc07b09; wu:fe17f08", "gene_names_refseq": "fc07b09; fe17f08; hcfc1b; wu:fc07b09; wu:fe17f08", "protein_names_uniprotkb": "Host cell factor 1; C1 factor", "protein_names_refseq": "host cell factor 1b", "tax_id": 7955, "disease": "methylmalonic acidemia and homocysteinemia cblX type (Disease Ontology:DOID:0111814); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:565206); (R-DRE-3214847); (R-DRE-5689603)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "23720042;23874272;25281006;26469318;27189481;28252024;36804358;39021799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.180389.1, SRR32588715.2301863.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_693583.3., [RefSeq]; HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC expression, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A8WIP5", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0002062 chondrocyte differentiation;GO:0048703 embryonic viscerocranium morphogenesis;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M9PQY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PRG7-1", "uniprot_id": "A0A8M9PRG7_DANRE", "mass": 512807.0, "length": 4666, "protein_name": "Protocadherin Fat 1a isoform X1", "gene_name": "fat1a", "organism": "Zebrafish", "refseq_name": "protocadherin Fat 1a isoform X1", "refseq_ac": "XP_021324881", "gene_names_uniprotkb": "fat1a; fat1; fat", "gene_names_refseq": "fat1a; fat1; fat", "protein_names_uniprotkb": "Protocadherin Fat 1a isoform X1", "protein_names_refseq": "protocadherin Fat 1a isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); nephrotic syndrome (Disease Ontology:DOID:1184); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:406172)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15749076;19439659;21925157;22830626;24706895;32591643;33071966;33316259;33829511;36598134", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0061386 closure of optic fissure;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048793 pronephros development;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PRG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PUH0-1", "uniprot_id": "A0A8M9PUH0_DANRE", "mass": 130236.0, "length": 1139, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp11c", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase IG isoform X1", "refseq_ac": "XP_021328509", "gene_names_uniprotkb": "atp11c", "gene_names_refseq": "atp11c", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase IG isoform X1", "tax_id": 7955, "disease": "X-linked congenital hemolytic anemia (Disease Ontology:DOID:0111846)", "pathway": " (dre:368385)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PUH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PLQ0-1", "uniprot_id": "A0A8M9PLQ0_DANRE", "mass": 318961.0, "length": 2831, "protein_name": "Neurofibromin", "gene_name": "nf1a", "organism": "Zebrafish", "refseq_name": "neurofibromin isoform X1", "refseq_ac": "XP_021322120", "gene_names_uniprotkb": "nf1a", "gene_names_refseq": "nf1a", "protein_names_uniprotkb": "Neurofibromin; Neurofibromatosis-related protein NF-1", "protein_names_refseq": "neurofibromin isoform X1", "tax_id": 7955, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:326708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046959 habituation;GO:0007507 heart development;GO:0007613 memory;GO:0001568 blood vessel development;GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PLQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q6K1-1", "uniprot_id": "F1Q6K1_DANRE", "mass": 294931.0, "length": 2621, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 24", "gene_name": "usp24", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 24 isoform X1", "refseq_ac": "XP_005170208", "gene_names_uniprotkb": "usp24", "gene_names_refseq": "usp24", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 24; 3.4.19.12; Deubiquitinating enzyme 24; Ubiquitin thioesterase 24; Ubiquitin-specific-processing protease 24", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 24 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:325631); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BHH2", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021551 central nervous system morphogenesis;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1Q6K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PWV8-1", "uniprot_id": "A0A8M9PWV8_DANRE", "mass": 403316.0, "length": 3701, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein isoform X1", "gene_name": "hspg2", "organism": "Zebrafish", "refseq_name": "basement membrane-specific heparan sulfate proteoglycan core protein isoform X1", "refseq_ac": "XP_021325650", "gene_names_uniprotkb": "hspg2", "gene_names_refseq": "hspg2", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein isoform X1", "protein_names_refseq": "basement membrane-specific heparan sulfate proteoglycan core protein isoform X1", "tax_id": 7955, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); Schwartz-Jampel syndrome 1 (Disease Ontology:DOID:0090005); Silverman-Handmaker type dyssegmental dysplasia (Disease Ontology:DOID:0090032); hypertension (Disease Ontology:DOID:10763); thanatophoric dysplasia (Disease Ontology:DOID:13481); osteochondrodysplasia (Disease Ontology:DOID:2256); carotid artery disease (Disease Ontology:DOID:3407); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (dre:565429)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005604 basement membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0072359 circulatory system development;GO:0030154 cell differentiation;GO:0001525 angiogenesis;GO:0014033 neural crest cell differentiation;GO:0043534 blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PWV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFK5-1", "uniprot_id": "E7FFK5_DANRE", "mass": 55571.0, "length": 490, "protein_name": "Phosphodiesterase", "gene_name": "pde7a", "organism": "Zebrafish", "refseq_name": "high affinity 3',5'-cyclic-AMP phosphodiesterase 7A", "refseq_ac": "NP_001161735", "gene_names_uniprotkb": "pde7a; cb1053; cb564; pde7al; wu:fk53d11; wu:fk94g02", "gene_names_refseq": "cb1053; cb564; pde7al; pde7a; wu:fk53d11; wu:fk94g02", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "high affinity 3',5'-cyclic-AMP phosphodiesterase 7A", "tax_id": 7955, "disease": "", "pathway": " (dre:100151215)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;26814702;28242613;35031423", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.1228756.1, SRR26395062.217752.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000024.1. On Jun 7, 2025 this sequence version replaced NP_001161735.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NSS2;E9QBI5", "ec_number_list": "3.1.4.-;3.1.4.53", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FFK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FH14-1", "uniprot_id": "E7FH14_DANRE", "mass": 123503.0, "length": 1128, "protein_name": "Histone deacetylase", "gene_name": "hdac5", "organism": "Zebrafish", "refseq_name": "histone deacetylase 5 isoform X1", "refseq_ac": "XP_685659", "gene_names_uniprotkb": "hdac5", "gene_names_refseq": "hdac5", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "histone deacetylase 5 isoform X1", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:557486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_685659.4. COMPLETENESS: full length., [RefSeq]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T5F3", "ec_number_list": "3.5.1.98;3.5.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0072114 pronephros morphogenesis;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FH14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q3H8-1", "uniprot_id": "A0A8M9Q3H8_DANRE", "mass": 75804.0, "length": 693, "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camk2b1", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X2", "refseq_ac": "XP_021331894", "gene_names_uniprotkb": "camk2b1; CAMK2Gb; camk2b; fj90d04; si:dkey-174n20.2; wu:fj90d04; zgc:165373", "gene_names_refseq": "CAMK2Gb; camk2b1; camk2b; fj90d04; si:dkey-174n20.2; wu:fj90d04; zgc:165373", "protein_names_uniprotkb": "calcium/calmodulin-dependent protein kinase; 2.7.11.17", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X2", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 54 (Disease Ontology:DOID:0080230); heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (dre:562064)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17103413;19345202;19500364;19823752;20630945;32165308;34346310;34935644;35525365;37860955", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0043226 organelle;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection", "go_biological_process": "GO:1903076 regulation of protein localization to plasma membrane;GO:0048168 regulation of neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9Q3H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDF3-1", "uniprot_id": "E7FDF3_DANRE", "mass": 126912.0, "length": 1127, "protein_name": "Guanylate cyclase", "gene_name": "gucy2g", "organism": "Zebrafish", "refseq_name": "guanylate cyclase 2G isoform X1", "refseq_ac": "XP_009305067", "gene_names_uniprotkb": "gucy2g", "gene_names_refseq": "gucy2g", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "guanylate cyclase 2G isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100333350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_009305067.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B4S0", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006182 cGMP biosynthetic process;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FDF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCY5-1", "uniprot_id": "E7FCY5_DANRE", "mass": 75055.0, "length": 674, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG1", "gene_name": "acsbg1", "organism": "Zebrafish", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1", "refseq_ac": "XP_001344904", "gene_names_uniprotkb": "acsbg1", "gene_names_refseq": "acsbg1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG1; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 1", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1", "tax_id": 7955, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (dre:100006023); (R-DRE-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_001344904.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PSY2", "ec_number_list": "6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FCY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXN1-1", "uniprot_id": "A0A8M9PXN1_DANRE", "mass": 267037.0, "length": 2365, "protein_name": "Voltage-dependent N-type calcium channel subunit alpha", "gene_name": "cacna1ba", "organism": "Zebrafish", "refseq_name": "calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1", "refseq_ac": "XP_021331853", "gene_names_uniprotkb": "cacna1ba; si:ch211-238e12.1", "gene_names_refseq": "cacna1ba; si:ch211-238e12.1", "protein_names_uniprotkb": "Voltage-dependent N-type calcium channel subunit alpha", "protein_names_refseq": "calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1", "tax_id": 7955, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); brain edema (Disease Ontology:DOID:4724); migraine (Disease Ontology:DOID:6364)", "pathway": " (dre:555941)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17937501;19222870;19500364;23616544;26469318;27605615;28096348;28252024;29739832", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021331853.1. COMPLETENESS: full length., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M9PXN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDT4-1", "uniprot_id": "E7FDT4_DANRE", "mass": 86107.0, "length": 774, "protein_name": "Meprin A subunit", "gene_name": "mep1bb", "organism": "Zebrafish", "refseq_name": "meprin A subunit beta isoform X1", "refseq_ac": "XP_009294699", "gene_names_uniprotkb": "mep1bb", "gene_names_refseq": "mep1bb", "protein_names_uniprotkb": "Meprin A subunit; 3.4.24.-; Endopeptidase-2", "protein_names_refseq": "meprin A subunit beta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:327586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AME9", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FDT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q897-1", "uniprot_id": "F1Q897_DANRE", "mass": 164104.0, "length": 1503, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "gene_name": "magi2a", "organism": "Zebrafish", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a", "refseq_ac": "NP_001314782", "gene_names_uniprotkb": "magi2a; fb82g11; magi2; si:dkey-97c7.1; si:dkeyp-86a5.1; wu:fb82g11", "gene_names_refseq": "fb82g11; magi2a; magi2; si:dkey-97c7.1; si:dkeyp-86a5.1; wu:fb82g11", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; Atrophin-1-interacting protein 1; BAI1-associated protein 1; Membrane-associated guanylate kinase inverted 1; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "protein_names_refseq": "membrane associated guanylate kinase, WW and PDZ domain containing 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a", "tax_id": 7955, "disease": "nephrotic syndrome type 15 (Disease Ontology:DOID:0080271); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:564112)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25306962;25556170;28252024;31010479;31349972", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On May 27, 2016 this sequence version replaced XP_009298672.1. Sequence Note:., [RefSeq]; Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8D6", "ec_number_list": "", "go_molecular_function": "GO:0016301 kinase activity;GO:0070699 type II activin receptor binding;GO:0046332 SMAD binding;GO:0030159 signaling receptor complex adaptor activity;GO:0031697 beta-1 adrenergic receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045202 synapse;GO:0005770 late endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0007165 signal transduction;GO:0043113 receptor clustering;GO:0039021 pronephric glomerulus development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1Q897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PTI7-1", "uniprot_id": "A0A8M9PTI7_DANRE", "mass": 335416.0, "length": 3056, "protein_name": "Serine/threonine-protein kinase WNK3", "gene_name": "wnk3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein wnk3 isoform X1", "refseq_ac": "XP_021325641", "gene_names_uniprotkb": "wnk3", "gene_names_refseq": "wnk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK3; 2.7.11.1; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3", "protein_names_refseq": "uncharacterized protein wnk3 isoform X1", "tax_id": 7955, "disease": "Prieto syndrome (Disease Ontology:DOID:0060805); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dre:567408)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019870 potassium channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:1904062 regulation of monoatomic cation transmembrane transport;GO:0035556 intracellular signal transduction;GO:1903288 positive regulation of potassium ion import across plasma membrane;GO:0050801 monoatomic ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PTI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q4L8-1", "uniprot_id": "F1Q4L8_DANRE", "mass": 96681.0, "length": 908, "protein_name": "CCR4-NOT transcription complex subunit 3", "gene_name": "cnot3a", "organism": "Zebrafish", "refseq_name": "CCR4-NOT transcription complex subunit 3a", "refseq_ac": "NP_001315047", "gene_names_uniprotkb": "cnot3a; cnot3; fb73b06; fc17h07; wu:fb73b06; wu:fc17h07; zgc:92813", "gene_names_refseq": "cnot3a; cnot3; fb73b06; fc17h07; wu:fb73b06; wu:fc17h07; zgc:92813", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 3; CCR4-associated factor 3", "protein_names_refseq": "CCR4-NOT transcription complex subunit 3a; CCR4-NOT transcription complex, subunit 3", "tax_id": 7955, "disease": "", "pathway": " (dre:449540)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;31231471;8373170", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01004335.1, SRR32588727.45649.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505387, SAMEA3505388 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Jun 25, 2025 this sequence version replaced NP_001315047.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P9K0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0006355 regulation of DNA-templated transcription;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0048565 digestive tract development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1Q4L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXY8-1", "uniprot_id": "A0A8M9PXY8_DANRE", "mass": 264491.0, "length": 2463, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "wnk1b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase WNK1 isoform X1", "refseq_ac": "XP_021327176", "gene_names_uniprotkb": "wnk1b", "gene_names_refseq": "wnk1b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase WNK1 isoform X1", "tax_id": 7955, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 2A (Disease Ontology:DOID:0070155); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dre:561159)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021327176.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0048919 posterior lateral line neuromast development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PXY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXC2-1", "uniprot_id": "A0A8M9PXC2_DANRE", "mass": 133773.0, "length": 1187, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase", "gene_name": "ppip5k1b", "organism": "Zebrafish", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1", "refseq_ac": "XP_073799127", "gene_names_uniprotkb": "ppip5k1b", "gene_names_refseq": "ppip5k1b", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; 2.7.4.24", "protein_names_refseq": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559938)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IY18", "ec_number_list": "2.7.4.24", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PXC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PL02-1", "uniprot_id": "A0A8M9PL02_DANRE", "mass": 139386.0, "length": 1213, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "plcb4a", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1", "refseq_ac": "XP_021322946", "gene_names_uniprotkb": "plcb4a", "gene_names_refseq": "plcb4a", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:100537538)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021322946.1. COMPLETENESS: full length., [RefSeq]; Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PL02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PL45-1", "uniprot_id": "A0A8M9PL45_DANRE", "mass": 111800.0, "length": 999, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "ephb2a", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 2 isoform X1", "refseq_ac": "XP_021325624", "gene_names_uniprotkb": "ephb2a", "gene_names_refseq": "ephb2a", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "ephrin type-B receptor 2 isoform X1", "tax_id": 7955, "disease": "cognitive disorder (Disease Ontology:DOID:1561); blood platelet disease (Disease Ontology:DOID:2218); middle cerebral artery infarction (Disease Ontology:DOID:3525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); ulcerative colitis (Disease Ontology:DOID:8577); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dre:562176)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0048013 ephrin receptor signaling pathway;GO:0001568 blood vessel development;GO:0060026 convergent extension", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PL45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PLD4-1", "uniprot_id": "A0A8M9PLD4_DANRE", "mass": 102520.0, "length": 923, "protein_name": "Serine/threonine-protein kinase", "gene_name": "prkd2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase D2", "refseq_ac": "XP_021322000", "gene_names_uniprotkb": "prkd2", "gene_names_refseq": "prkd2", "protein_names_uniprotkb": "Serine/threonine-protein kinase; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase D2", "tax_id": 7955, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dre:101882608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.11.12;2.7.11.39;2.7.11.11;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0003272 endocardial cushion formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PLD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PM39-1", "uniprot_id": "A0A8M9PM39_DANRE", "mass": 41241.0, "length": 358, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "gene_name": "b3gat1a", "organism": "Zebrafish", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1", "refseq_ac": "XP_005173702", "gene_names_uniprotkb": "b3gat1a; GlcAT-P; b3gat1; si:dkey-22o20.1", "gene_names_refseq": "GlcAT-P; b3gat1a; b3gat1; si:dkey-22o20.1", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; 2.4.1.135", "protein_names_refseq": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1", "tax_id": 7955, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (dre:548607)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27086029;27189481;36077499", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HTE8", "ec_number_list": "2.4.1.135", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PM39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PMM3-1", "uniprot_id": "A0A8M9PMM3_DANRE", "mass": 37832.0, "length": 331, "protein_name": "Beta-parvin isoform X2", "gene_name": "parvb", "organism": "Zebrafish", "refseq_name": "beta-parvin isoform X2", "refseq_ac": "XP_021326129", "gene_names_uniprotkb": "parvb; fd02e01; wu:fd02e01; zgc:73117", "gene_names_refseq": "fd02e01; parvb; wu:fd02e01; zgc:73117", "protein_names_uniprotkb": "Beta-parvin isoform X2", "protein_names_refseq": "beta-parvin isoform X2", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0030036 actin cytoskeleton organization;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PMM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PNT5-1", "uniprot_id": "A0A8M9PNT5_DANRE", "mass": 47698.0, "length": 418, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr88", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2", "refseq_ac": "XP_021323891", "gene_names_uniprotkb": "pimr88", "gene_names_refseq": "pimr88", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2", "tax_id": 7955, "disease": "", "pathway": " (dre:100006996)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021323891.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PNT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PNY8-1", "uniprot_id": "A0A8M9PNY8_DANRE", "mass": 66036.0, "length": 595, "protein_name": "Muscarinic acetylcholine receptor", "gene_name": "chrm3a", "organism": "Zebrafish", "refseq_name": "muscarinic acetylcholine receptor M3", "refseq_ac": "XP_021328763", "gene_names_uniprotkb": "chrm3a", "gene_names_refseq": "chrm3a", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor", "protein_names_refseq": "muscarinic acetylcholine receptor M3", "tax_id": 7955, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); prune belly syndrome (Disease Ontology:DOID:0060889); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bladder disease (Disease Ontology:DOID:365); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (dre:571679); (R-DRE-390648); (R-DRE-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HR95;X1WHZ7", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0045987 positive regulation of smooth muscle contraction;GO:0046541 saliva secretion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PNY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PPN0-1", "uniprot_id": "A0A8M9PPN0_DANRE", "mass": 288987.0, "length": 2603, "protein_name": "Probable JmjC domain-containing histone demethylation protein 2C", "gene_name": "jmjd1ca", "organism": "Zebrafish", "refseq_name": "probable JmjC domain-containing histone demethylation protein 2C", "refseq_ac": "XP_021323145", "gene_names_uniprotkb": "jmjd1ca", "gene_names_refseq": "jmjd1ca", "protein_names_uniprotkb": "Probable JmjC domain-containing histone demethylation protein 2C", "protein_names_refseq": "probable JmjC domain-containing histone demethylation protein 2C", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:571586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0051213 dioxygenase activity;GO:0003712 transcription coregulator activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PPN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PPX1-1", "uniprot_id": "A0A8M9PPX1_DANRE", "mass": 45584.0, "length": 404, "protein_name": "Synaptotagmin-1b isoform X1", "gene_name": "syt1b", "organism": "Zebrafish", "refseq_name": "synaptotagmin-1b isoform X1", "refseq_ac": "XP_021323234", "gene_names_uniprotkb": "syt1b; si:dkey-30c15.14", "gene_names_refseq": "si:dkey-30c15.14; syt1b", "protein_names_uniprotkb": "Synaptotagmin-1b isoform X1", "protein_names_refseq": "synaptotagmin-1b isoform X1", "tax_id": 7955, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (dre:100034471)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15238157;17672888;20078875;25630924;27189481;28252024;34468021;38765140", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021323234.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M9PPX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQ01-1", "uniprot_id": "A0A8M9PQ01_DANRE", "mass": 80381.0, "length": 704, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "si:dkeyp-50d11.2", "organism": "Zebrafish", "refseq_name": "calpain-1 catalytic subunit isoform X1", "refseq_ac": "XP_021329108", "gene_names_uniprotkb": "si:dkeyp-50d11.2", "gene_names_refseq": "si:dkeyp-50d11.2", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; 3.4.22.53; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain", "protein_names_refseq": "calpain-1 catalytic subunit isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQ01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQ05-1", "uniprot_id": "A0A8M9PQ05_DANRE", "mass": 61068.0, "length": 542, "protein_name": "Uridine-cytidine kinase", "gene_name": "si:ch211-243j20.2", "organism": "Zebrafish", "refseq_name": "uridine-cytidine kinase-like 1 isoform X1", "refseq_ac": "XP_021324336", "gene_names_uniprotkb": "si:ch211-243j20.2", "gene_names_refseq": "si:ch211-243j20.2", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563597)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQ05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQ80-1", "uniprot_id": "A0A8M9PQ80_DANRE", "mass": 33751.0, "length": 310, "protein_name": "Protein sprouty homolog 4", "gene_name": "spry4", "organism": "Zebrafish", "refseq_name": "protein sprouty homolog 4", "refseq_ac": "NP_571901", "gene_names_uniprotkb": "spry4; cb511; sprouty4; wu:fb92b06; zSpry4", "gene_names_refseq": "cb511; sprouty4; spry4; wu:fb92b06; zSpry4", "protein_names_uniprotkb": "Protein sprouty homolog 4", "protein_names_refseq": "protein sprouty homolog 4", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 17 with or without anosmia (Disease Ontology:DOID:0090079)", "pathway": " (dre:114437)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11861475;12963112;14660549;14711879;15151985;34568948;35588359;37665167;38900908;39133135", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016213.1, BC076067.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1 and EH447258.1. On May 31, 2017 this sequence version replaced NP_571901.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QZW4", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0048741 skeletal muscle fiber development;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PQ80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQA7-1", "uniprot_id": "A0A8M9PQA7_DANRE", "mass": 52465.0, "length": 459, "protein_name": "Serine/threonine-protein kinase CHK1", "gene_name": "chek1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Chk1", "refseq_ac": "NP_956487", "gene_names_uniprotkb": "chek1; id:ibd2720; zgc:56093", "gene_names_refseq": "chek1; id:ibd2720; zgc:56093", "protein_names_uniprotkb": "Serine/threonine-protein kinase CHK1; 2.7.11.1; CHK1 checkpoint homolog; Checkpoint kinase-1; Serine/threonine-protein kinase Chk1", "protein_names_refseq": "CHK1 checkpoint homolog; serine/threonine-protein kinase Chk1", "tax_id": 7955, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01003887.1, SRR26395063.245006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On or before Jul 18, 2025 this sequence version replaced XP_021324451.1, NP_956487.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005694 chromosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQC9-1", "uniprot_id": "A0A8M9PQC9_DANRE", "mass": 69019.0, "length": 606, "protein_name": "Prolactin receptor", "gene_name": "prlra", "organism": "Zebrafish", "refseq_name": "prolactin receptor a isoform X1", "refseq_ac": "XP_021324476", "gene_names_uniprotkb": "prlra; PRLR; prlr; wu:fj65c07", "gene_names_refseq": "prlra; prlr; wu:fj65c07", "protein_names_uniprotkb": "Prolactin receptor; PRL-R", "protein_names_refseq": "prolactin receptor a isoform X1", "tax_id": 7955, "disease": "familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (R-DRE-1170546); (R-DRE-982772)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I8H2;F1QG81", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQM8-1", "uniprot_id": "A0A8M9PQM8_DANRE", "mass": 24835.0, "length": 220, "protein_name": "BCL2 like 16 isoform X1", "gene_name": "bcl2l16", "organism": "Zebrafish", "refseq_name": "BCL2 like 16 isoform X1", "refseq_ac": "XP_021333847", "gene_names_uniprotkb": "bcl2l16", "gene_names_refseq": "bcl2l16", "protein_names_uniprotkb": "BCL2 like 16 isoform X1", "protein_names_refseq": "BCL2 like 16 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G607;A0AC58G610;A0AC58G611;A0AC58G631", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0043065 positive regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria;GO:0042074 cell migration involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQQ3-1", "uniprot_id": "A0A8M9PQQ3_DANRE", "mass": 304547.0, "length": 2665, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "itpr2", "organism": "Zebrafish", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "refseq_ac": "XP_021323455", "gene_names_uniprotkb": "itpr2", "gene_names_refseq": "itpr2", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "tax_id": 7955, "disease": "isolated anhidrosis with normal sweat glands (Disease Ontology:DOID:0060603); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:562585)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005509 calcium ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQW6-1", "uniprot_id": "A0A8M9PQW6_DANRE", "mass": 233827.0, "length": 2068, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha", "gene_name": "cacna1fb", "organism": "Zebrafish", "refseq_name": "calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1", "refseq_ac": "XP_021333942", "gene_names_uniprotkb": "cacna1fb; ZfCav1.4; cacna1f", "gene_names_refseq": "ZfCav1.4; cacna1fb; cacna1f", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha", "protein_names_refseq": "calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1", "tax_id": 7955, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Aland Island eye disease (Disease Ontology:DOID:0050630); Timothy syndrome (Disease Ontology:DOID:0060173); congenital stationary night blindness 2A (Disease Ontology:DOID:0110871); X-linked cone-rod dystrophy 3 (Disease Ontology:DOID:0111007); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (dre:559964)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16568031;19222870;22832038;24180662;24419318;29739832;30909129;33951474;35600071;38003559", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008331 high voltage-gated calcium channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PQW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PQX0-1", "uniprot_id": "A0A8M9PQX0_DANRE", "mass": 88969.0, "length": 795, "protein_name": "Potassium voltage-gated channel subfamily KQT member 3", "gene_name": "kcnq3", "organism": "Zebrafish", "refseq_name": "potassium voltage-gated channel subfamily KQT member 3", "refseq_ac": "XP_021323522", "gene_names_uniprotkb": "kcnq3", "gene_names_refseq": "kcnq3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 3", "protein_names_refseq": "potassium voltage-gated channel subfamily KQT member 3", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); autistic disorder (Disease Ontology:DOID:12849); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (dre:799747)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0045202 synapse;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PQX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PRF1-1", "uniprot_id": "A0A8M9PRF1_DANRE", "mass": 44450.0, "length": 399, "protein_name": "Voltage-gated potassium channel subunit beta-1", "gene_name": "kcnab1b", "organism": "Zebrafish", "refseq_name": "voltage-gated potassium channel subunit beta-1 isoform X1", "refseq_ac": "XP_683674", "gene_names_uniprotkb": "kcnab1b", "gene_names_refseq": "kcnab1b", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1", "protein_names_refseq": "voltage-gated potassium channel subunit beta-1 isoform X1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:555922)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_683674.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.2;1.6.-.-", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005249 voltage-gated potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0044224 juxtaparanode region of axon", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PRF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PS81-1", "uniprot_id": "A0A8M9PS81_DANRE", "mass": 79097.0, "length": 722, "protein_name": "Junction plakoglobin", "gene_name": "jupb", "organism": "Zebrafish", "refseq_name": "junction plakoglobin", "refseq_ac": "XP_002665522", "gene_names_uniprotkb": "jupb", "gene_names_refseq": "jupb", "protein_names_uniprotkb": "Junction plakoglobin", "protein_names_refseq": "junction plakoglobin", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); endometrial hyperplasia (Disease Ontology:DOID:0080365); Naxos disease (Disease Ontology:DOID:0080551); arrhythmogenic right ventricular dysplasia 12 (Disease Ontology:DOID:0110083); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); palmoplantar keratosis (Disease Ontology:DOID:3390); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603); neuropathy (Disease Ontology:DOID:870); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100330886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002665522.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HZX2;A0AC58HZX3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0045296 cadherin binding;GO:0019903 protein phosphatase binding;GO:0045294 alpha-catenin binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0014704 intercalated disc;GO:0016342 catenin complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0098609 cell-cell adhesion;GO:0060070 canonical Wnt signaling pathway;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PS81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PSE3-1", "uniprot_id": "A0A8M9PSE3_DANRE", "mass": 51440.0, "length": 448, "protein_name": "Glycine receptor subunit alpha-2 isoform X1", "gene_name": "glra2", "organism": "Zebrafish", "refseq_name": "glycine receptor subunit alpha-2 isoform X1", "refseq_ac": "XP_021334452", "gene_names_uniprotkb": "glra2; si:ch211-12n8.3", "gene_names_refseq": "glra2; si:ch211-12n8.3", "protein_names_uniprotkb": "Glycine receptor subunit alpha-2 isoform X1", "protein_names_refseq": "glycine receptor subunit alpha-2 isoform X1", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PSE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PT65-1", "uniprot_id": "A0A8M9PT65_DANRE", "mass": 71854.0, "length": 639, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "si:dkey-93l1.6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-93l1.6", "refseq_ac": "XP_021330208", "gene_names_uniprotkb": "si:dkey-93l1.6", "gene_names_refseq": "si:dkey-93l1.6", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein si:dkey-93l1.6", "tax_id": 7955, "disease": "", "pathway": " (dre:100149418)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021330208.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PT65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PTH9-1", "uniprot_id": "A0A8M9PTH9_DANRE", "mass": 66167.0, "length": 606, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr124", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pimr124", "refseq_ac": "XP_021324375", "gene_names_uniprotkb": "pimr124", "gene_names_refseq": "pimr124", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein pimr124", "tax_id": 7955, "disease": "", "pathway": " (dre:560658)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021324375.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PTH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PTI3-1", "uniprot_id": "A0A8M9PTI3_DANRE", "mass": 42981.0, "length": 370, "protein_name": "Septin", "gene_name": "septin5b", "organism": "Zebrafish", "refseq_name": "septin 5b isoform X1", "refseq_ac": "XP_021334832", "gene_names_uniprotkb": "septin5b; sept5b; zgc:100950", "gene_names_refseq": "sept5b; septin5b; zgc:100950", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "septin 5b isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0008021 synaptic vesicle;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PTI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PTJ2-1", "uniprot_id": "A0A8M9PTJ2_DANRE", "mass": 510219.0, "length": 4562, "protein_name": "Low-density lipoprotein receptor-related protein 1 isoform X1", "gene_name": "lrp1ab", "organism": "Zebrafish", "refseq_name": "low-density lipoprotein receptor-related protein 1 isoform X1", "refseq_ac": "XP_021325646", "gene_names_uniprotkb": "lrp1ab", "gene_names_refseq": "lrp1ab", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 1 isoform X1", "protein_names_refseq": "low-density lipoprotein receptor-related protein 1 isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); omphalocele (Disease Ontology:DOID:0060327); keratosis pilaris atrophicans (Disease Ontology:DOID:0080751); Alzheimer's disease (Disease Ontology:DOID:10652); gastroschisis (Disease Ontology:DOID:11044); sciatic neuropathy (Disease Ontology:DOID:11446); alcoholic hepatitis (Disease Ontology:DOID:12351); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); myocardial infarction (Disease Ontology:DOID:5844); prostate carcinoma in situ (Disease Ontology:DOID:8634); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dre:565797)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0005509 calcium ion binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0043226 organelle", "go_biological_process": "GO:0006909 phagocytosis;GO:0006898 receptor-mediated endocytosis;GO:0150093 amyloid-beta clearance by transcytosis;GO:1901342 regulation of vasculature development;GO:0150094 amyloid-beta clearance by cellular catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PTJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PU51-1", "uniprot_id": "A0A8M9PU51_DANRE", "mass": 101729.0, "length": 888, "protein_name": "[heparan sulfate]-glucosamine N-sulfotransferase", "gene_name": "ndst2a", "organism": "Zebrafish", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1", "refseq_ac": "XP_021328383", "gene_names_uniprotkb": "ndst2a", "gene_names_refseq": "ndst2a", "protein_names_uniprotkb": "[heparan sulfate]-glucosamine N-sulfotransferase; 2.8.2.8", "protein_names_refseq": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (dre:793524)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H4M1;A0AC58H4M9;A0AC58H4N1;A0AC58H4N3;A0AC58H4N4;A0AC58H4P8;A0AC58H4Q3", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PU51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PVG7-1", "uniprot_id": "A0A8M9PVG7_DANRE", "mass": 53192.0, "length": 479, "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "htr7a", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 7", "refseq_ac": "XP_021328829", "gene_names_uniprotkb": "htr7a", "gene_names_refseq": "htr7a", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 7; Serotonin receptor 7", "protein_names_refseq": "5-hydroxytryptamine receptor 7", "tax_id": 7955, "disease": "amnestic disorder (Disease Ontology:DOID:10914); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); childhood absence epilepsy (Disease Ontology:DOID:1825); anxiety disorder (Disease Ontology:DOID:2030); migraine (Disease Ontology:DOID:6364); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dre:562111); (R-DRE-390666); (R-DRE-9706019)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021328829.1. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FFG8", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PVG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PWG9-1", "uniprot_id": "A0A8M9PWG9_DANRE", "mass": 255342.0, "length": 2289, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "plce1", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1", "refseq_ac": "XP_021335822", "gene_names_uniprotkb": "plce1", "gene_names_refseq": "plce1", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1", "tax_id": 7955, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); nephrotic syndrome type 3 (Disease Ontology:DOID:0080382); nephrotic syndrome (Disease Ontology:DOID:1184); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (dre:568288)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0016042 lipid catabolic process;GO:0007265 Ras protein signal transduction;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PWG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXC6-1", "uniprot_id": "A0A8M9PXC6_DANRE", "mass": 75108.0, "length": 656, "protein_name": "ATP-binding cassette sub-family D member 3", "gene_name": "abcd3a", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family D member 3a isoform X1", "refseq_ac": "XP_021325800", "gene_names_uniprotkb": "abcd3a; fb59g09; fd60b04; wu:fb59g09; wu:fd60b04; zgc:55740", "gene_names_refseq": "abcd3a; fb59g09; fd60b04; wu:fb59g09; wu:fd60b04; zgc:55740", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 3; 70 kDa peroxisomal membrane protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 3a isoform X1", "tax_id": 7955, "disease": "congenital bile acid synthesis defect 5 (Disease Ontology:DOID:0111066); adrenoleukodystrophy (Disease Ontology:DOID:10588); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.-;7.6.2.-", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0015910 long-chain fatty acid import into peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PXC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PXD6-1", "uniprot_id": "A0A8M9PXD6_DANRE", "mass": 164770.0, "length": 1460, "protein_name": "Glutamate receptor", "gene_name": "grin2aa", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, NMDA 2A", "refseq_ac": "XP_021329529", "gene_names_uniprotkb": "grin2aa", "gene_names_refseq": "grin2aa", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 2A", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:563297)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004972 NMDA glutamate receptor activity", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0060079 excitatory postsynaptic potential;GO:0035249 synaptic transmission, glutamatergic;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PXD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PZ09-1", "uniprot_id": "A0A8M9PZ09_DANRE", "mass": 140166.0, "length": 1247, "protein_name": "Anion exchange protein", "gene_name": "slc4a2a", "organism": "Zebrafish", "refseq_name": "anion exchange protein 2a isoform X1", "refseq_ac": "XP_005163568", "gene_names_uniprotkb": "slc4a2a; slc4a2", "gene_names_refseq": "slc4a2a; slc4a2", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "anion exchange protein 2a isoform X1", "tax_id": 7955, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prediabetes syndrome (Disease Ontology:DOID:11716); osteopetrosis (Disease Ontology:DOID:13533); anemia (Disease Ontology:DOID:2355)", "pathway": " (dre:566075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0006820 monoatomic anion transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PZ09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PZK1-1", "uniprot_id": "A0A8M9PZK1_DANRE", "mass": 84034.0, "length": 748, "protein_name": "BCL6A transcription repressor a isoform X1", "gene_name": "bcl6aa", "organism": "Zebrafish", "refseq_name": "BCL6A transcription repressor a isoform X1", "refseq_ac": "XP_021332488", "gene_names_uniprotkb": "bcl6aa; bcl6a; bcl6; zgc:73162", "gene_names_refseq": "bcl6aa; bcl6a; bcl6; zgc:73162", "protein_names_uniprotkb": "BCL6A transcription repressor a isoform X1", "protein_names_refseq": "BCL6A transcription repressor a isoform X1", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (dre:393707)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16076494;19439512;22855815;23669349;25132384;27356472;28114274;29257949;30077009;36389136", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0050776 regulation of immune response;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M9PZK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PZU3-1", "uniprot_id": "A0A8M9PZU3_DANRE", "mass": 43922.0, "length": 389, "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha", "gene_name": "prkacaa", "organism": "Zebrafish", "refseq_name": "protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1", "refseq_ac": "XP_021326630", "gene_names_uniprotkb": "prkacaa; zgc:158799", "gene_names_refseq": "prkacaa; zgc:158799", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit alpha; 2.7.11.11", "protein_names_refseq": "protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1", "tax_id": 7955, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9PZU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PZW8-1", "uniprot_id": "A0A8M9PZW8_DANRE", "mass": 132489.0, "length": 1166, "protein_name": "Protein diaphanous homolog 2", "gene_name": "diaph2", "organism": "Zebrafish", "refseq_name": "protein diaphanous homolog 2 isoform X1", "refseq_ac": "XP_021336921", "gene_names_uniprotkb": "diaph2", "gene_names_refseq": "diaph2", "protein_names_uniprotkb": "Protein diaphanous homolog 2; Diaphanous-related formin-2", "protein_names_refseq": "protein diaphanous homolog 2 isoform X1", "tax_id": 7955, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); primary ovarian insufficiency 2A (Disease Ontology:DOID:0080858); microcephaly (Disease Ontology:DOID:10907); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dre:556029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005884 actin filament", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030041 actin filament polymerization;GO:0042074 cell migration involved in gastrulation;GO:0048477 oogenesis;GO:0040001 establishment of mitotic spindle localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PZW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q057-1", "uniprot_id": "A0A8M9Q057_DANRE", "mass": 56798.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr145", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2", "refseq_ac": "XP_021328001", "gene_names_uniprotkb": "pimr145", "gene_names_refseq": "pimr145", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2", "tax_id": 7955, "disease": "", "pathway": " (dre:562179)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021328001.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q057-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q0D3-1", "uniprot_id": "A0A8M9Q0D3_DANRE", "mass": 138893.0, "length": 1212, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp11a", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase IH isoform X1", "refseq_ac": "XP_021332758", "gene_names_uniprotkb": "atp11a", "gene_names_refseq": "atp11a", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase IH isoform X1", "tax_id": 7955, "disease": "hypomyelinating leukodystrophy 24 (Disease Ontology:DOID:0070406); autosomal dominant nonsyndromic deafness 84 (Disease Ontology:DOID:0070604)", "pathway": " (dre:562925)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0015914 phospholipid transport;GO:0035845 photoreceptor cell outer segment organization;GO:0035675 neuromast hair cell development;GO:0120045 stereocilium maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q0D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q0J1-1", "uniprot_id": "A0A8M9Q0J1_DANRE", "mass": 124219.0, "length": 1108, "protein_name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "gene_name": "inpp5d", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1", "refseq_ac": "XP_021329769", "gene_names_uniprotkb": "inpp5d", "gene_names_refseq": "inpp5d", "protein_names_uniprotkb": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; 3.1.3.86", "protein_names_refseq": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1", "tax_id": 7955, "disease": "Paget's disease of bone (Disease Ontology:DOID:5408); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:559103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0046856 phosphatidylinositol dephosphorylation;GO:0002376 immune system process;GO:0090024 negative regulation of neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q0J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q2S7-1", "uniprot_id": "A0A8M9Q2S7_DANRE", "mass": 87567.0, "length": 769, "protein_name": "cGMP-dependent protein kinase", "gene_name": "prkg2", "organism": "Zebrafish", "refseq_name": "cGMP-dependent protein kinase 2 isoform X1", "refseq_ac": "XP_073805736", "gene_names_uniprotkb": "prkg2; si:dkey-18e17.2", "gene_names_refseq": "prkg2; si:dkey-18e17.2", "protein_names_uniprotkb": "cGMP-dependent protein kinase; 2.7.11.12", "protein_names_refseq": "cGMP-dependent protein kinase 2 isoform X1", "tax_id": 7955, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); acromesomelic dysplasia 4 (Disease Ontology:DOID:0081238); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (dre:100125912)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19500364;30269816;32186706", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JGY3", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030553 cGMP binding", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M9Q2S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q2T2-1", "uniprot_id": "A0A8M9Q2T2_DANRE", "mass": 212258.0, "length": 1875, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "trpm6", "organism": "Zebrafish", "refseq_name": "transient receptor potential cation channel subfamily M member 6 isoform X1", "refseq_ac": "XP_021331654", "gene_names_uniprotkb": "trpm6", "gene_names_refseq": "trpm6", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "transient receptor potential cation channel subfamily M member 6 isoform X1", "tax_id": 7955, "disease": "chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); intestinal hypomagnesemia 1 (Disease Ontology:DOID:0060883); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (dre:100149353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021331654.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;1.5.1.2;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005262 calcium channel activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q2T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q2T8-1", "uniprot_id": "A0A8M9Q2T8_DANRE", "mass": 95713.0, "length": 852, "protein_name": "dynamin GTPase", "gene_name": "dnm1a", "organism": "Zebrafish", "refseq_name": "dynamin-1a isoform X2", "refseq_ac": "XP_021331659", "gene_names_uniprotkb": "dnm1a; dnm1; si:dkey-246l19.2", "gene_names_refseq": "dnm1a; dnm1; si:dkey-246l19.2", "protein_names_uniprotkb": "dynamin GTPase; 3.6.5.5", "protein_names_refseq": "dynamin-1a isoform X2", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); generalized epilepsy (Disease Ontology:DOID:1827); collagen disease (Disease Ontology:DOID:854)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0016020 membrane", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0006897 endocytosis;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q2T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q3W1-1", "uniprot_id": "A0A8M9Q3W1_DANRE", "mass": 90718.0, "length": 831, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "rnf43", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF43 isoform X1", "refseq_ac": "XP_021332049", "gene_names_uniprotkb": "rnf43", "gene_names_refseq": "rnf43", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF43 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0038018 Wnt receptor catabolic process;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q3W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q3Z2-1", "uniprot_id": "A0A8M9Q3Z2_DANRE", "mass": 55554.0, "length": 483, "protein_name": "Stromelysin-3", "gene_name": "mmp11a", "organism": "Zebrafish", "refseq_name": "stromelysin-3", "refseq_ac": "XP_021334138", "gene_names_uniprotkb": "mmp11a", "gene_names_refseq": "mmp11a", "protein_names_uniprotkb": "Stromelysin-3; Matrix metalloproteinase-11", "protein_names_refseq": "stromelysin-3", "tax_id": 7955, "disease": "", "pathway": " (dre:563753); (R-DRE-1474228); (R-DRE-1592389)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FCZ5", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q3Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9Q4I8-1", "uniprot_id": "A0A8M9Q4I8_DANRE", "mass": 44617.0, "length": 403, "protein_name": "Cytoplasmic protein", "gene_name": "nck2a", "organism": "Zebrafish", "refseq_name": "cytoplasmic protein NCK2a isoform X1", "refseq_ac": "XP_009302746", "gene_names_uniprotkb": "nck2a; Nck2; zgc:55283", "gene_names_refseq": "Nck2; nck2a; zgc:55283", "protein_names_uniprotkb": "Cytoplasmic protein", "protein_names_refseq": "cytoplasmic protein NCK2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:393972); (R-DRE-186763); (R-DRE-373753); (R-DRE-3928664); (R-DRE-4420097); (R-DRE-9013420); (R-DRE-9013424)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1R1C3", "ec_number_list": "", "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0048013 ephrin receptor signaling pathway;GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9Q4I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q7X5-1", "uniprot_id": "F1Q7X5_DANRE", "mass": 311085.0, "length": 2708, "protein_name": "Centromere protein F isoform X1", "gene_name": "cenpf", "organism": "Zebrafish", "refseq_name": "centromere protein F isoform X1", "refseq_ac": "XP_002665261", "gene_names_uniprotkb": "cenpf", "gene_names_refseq": "cenpf", "protein_names_uniprotkb": "Centromere protein F isoform X1", "protein_names_refseq": "centromere protein F isoform X1", "tax_id": 7955, "disease": "Stromme syndrome (Disease Ontology:DOID:0110595); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:497403); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002665261.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RE46", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0000775 chromosome, centromeric region;GO:0000922 spindle pole;GO:0005634 nucleus", "go_biological_process": "GO:0060271 cilium assembly;GO:0051310 metaphase chromosome alignment;GO:0000278 mitotic cell cycle;GO:0001822 kidney development;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1Q7X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDW8-1", "uniprot_id": "TRD7B_DANRE", "mass": 121834.0, "length": 1085, "protein_name": "Tudor domain-containing protein 7B", "gene_name": "tdrd7b", "organism": "Zebrafish", "refseq_name": "tudor domain-containing protein 7B", "refseq_ac": "NP_001340858", "gene_names_uniprotkb": "tdrd7b; sb:cb829", "gene_names_refseq": "sb:cb829; tdrd7b", "protein_names_uniprotkb": "Tudor domain-containing protein 7B", "protein_names_refseq": "tudor domain-containing protein 7B", "tax_id": 7955, "disease": "cataract 36 (Disease Ontology:DOID:0110247)", "pathway": " (dre:100004703)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23594743;24240475;24683187;26469318;30399145;31059868;33705730", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01018275.1, GFIL01041870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476762, SAMEA4476794 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jul 29, 2017 this sequence version replaced XP_005166552.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0035770 ribonucleoprotein granule;GO:0043186 P granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0010608 post-transcriptional regulation of gene expression;GO:0034587 piRNA processing;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E7FDW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FH11-1", "uniprot_id": "ZD18A_DANRE", "mass": 51688.0, "length": 467, "protein_name": "Palmitoyltransferase ZDHHC18-A", "gene_name": "zdhhc18a", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC18a", "refseq_ac": "NP_001071031", "gene_names_uniprotkb": "zdhhc18a; pigv; zdhhc18; zgc:153461", "gene_names_refseq": "zdhhc18a; zdhhc18; zgc:153461", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC18-A; 2.3.1.225; Zinc finger DHHC domain-containing protein 18-A", "protein_names_refseq": "palmitoyltransferase ZDHHC18a; zinc finger DHHC-type containing 18a; zinc finger DHHC-type palmitoyltransferase 18a; zinc finger, DHHC-type containing 18", "tax_id": 7955, "disease": "", "pathway": " (dre:564062)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505380, SAMEA3505383 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC124360.1. On or before Nov 9, 2006 this sequence version replaced XP_687214.1, XP_708689.1, XP_708690.1., [RefSeq]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q6I2;Q08C71", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FH11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q4N7-1", "uniprot_id": "F1Q4N7_DANRE", "mass": 29473.0, "length": 259, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member", "gene_name": "anp32b", "organism": "Zebrafish", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member B", "refseq_ac": "NP_997768", "gene_names_uniprotkb": "anp32b; cb908; fa99a11; wu:fa28c10; wu:fa99a11; wu:fb40e12; zgc:77745", "gene_names_refseq": "anp32b; cb908; fa99a11; wu:fa28c10; wu:fa99a11; wu:fb40e12; zgc:77745", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member", "protein_names_refseq": "acidic leucine-rich nuclear phosphoprotein 32 family member B", "tax_id": 7955, "disease": "", "pathway": " (dre:322000)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15895553;16109975;24198278;26469318;30097520;32640983;34185526;34315984;39000319;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CK027930.1, CN022733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476766 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB365247.1, CV118158.1, BC065856.1 and BI844858.1. On or before Sep 14, 2006 this sequence version replaced XP_708284.1, XP_686206.1, XP_708285.1, NP_997768.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1Z3N3", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "F1Q4N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q4S1-1", "uniprot_id": "ATP9B_DANRE", "mass": 127041.0, "length": 1125, "protein_name": "Probable phospholipid-transporting ATPase IIB", "gene_name": "atp9b", "organism": "Zebrafish", "refseq_name": "probable phospholipid-transporting ATPase IIB isoform X2", "refseq_ac": "XP_009292513", "gene_names_uniprotkb": "atp9b; si:ch211-198c22.1", "gene_names_refseq": "atp9b; si:ch211-198c22.1", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IIB; 7.6.2.1; ATPase class II type 9B", "protein_names_refseq": "probable phospholipid-transporting ATPase IIB isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:568160); (R-DRE-936837)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1Q4S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FGL6-1", "uniprot_id": "E7FGL6_DANRE", "mass": 42723.0, "length": 371, "protein_name": "Matrix metalloproteinase-23", "gene_name": "mmp23ba", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-23 isoform X1", "refseq_ac": "XP_009302611", "gene_names_uniprotkb": "mmp23ba", "gene_names_refseq": "mmp23ba", "protein_names_uniprotkb": "Matrix metalloproteinase-23", "protein_names_refseq": "matrix metalloproteinase-23 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882601)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B5A7", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FGL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1Q5Z6-1", "uniprot_id": "F1Q5Z6_DANRE", "mass": 75134.0, "length": 682, "protein_name": "HBS1-like protein", "gene_name": "hbs1l", "organism": "Zebrafish", "refseq_name": "HBS1-like protein", "refseq_ac": "NP_001295477", "gene_names_uniprotkb": "hbs1l; wu:fc23c07; zgc:55400", "gene_names_refseq": "hbs1l; wu:fc23c07; zgc:55400", "protein_names_uniprotkb": "HBS1-like protein", "protein_names_refseq": "HBS1-like protein", "tax_id": 7955, "disease": "beta thalassemia (Disease Ontology:DOID:12241)", "pathway": " (dre:324267); (R-DRE-429958); (R-DRE-9954714)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15520368;25326603;27189481;33600438", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588718.30539367.1, SRR32588725.11002584.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1, EB894746.1 and CT587014.2. On May 12, 2015 this sequence version replaced NP_955970.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P708", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006412 translation;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1Q5Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FEJ5-1", "uniprot_id": "E7FEJ5_DANRE", "mass": 138494.0, "length": 1244, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1", "gene_name": "adamts18", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1", "refseq_ac": "XP_009301678", "gene_names_uniprotkb": "adamts18", "gene_names_refseq": "adamts18", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100150128); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AUH4", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FEJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FBZ6-1", "uniprot_id": "E7FBZ6_DANRE", "mass": 17616.0, "length": 160, "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "lamtor1", "organism": "Zebrafish", "refseq_name": "ragulator complex protein LAMTOR1", "refseq_ac": "NP_001269069", "gene_names_uniprotkb": "lamtor1", "gene_names_refseq": "lamtor1", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1", "protein_names_refseq": "ragulator complex protein LAMTOR1-like; ragulator complex protein LAMTOR1", "tax_id": 7955, "disease": "", "pathway": " (dre:100329656); (R-DRE-1632852); (R-DRE-165159); (R-DRE-166208); (R-DRE-380972); (R-DRE-5628897); (R-DRE-6798695); (R-DRE-8943724); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013406); (R-DRE-9013407); (R-DRE-9013408); (R-DRE-9013423); (R-DRE-9639288)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "26469318;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH490604.1, EH577592.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505378, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Aug 20, 2013 this sequence version replaced XP_002667853.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P653", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045121 membrane raft;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0071986 Ragulator complex", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0001919 regulation of receptor recycling;GO:0042632 cholesterol homeostasis;GO:0007040 lysosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FBZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FC63-1", "uniprot_id": "E7FC63_DANRE", "mass": 135395.0, "length": 1183, "protein_name": "adenylate cyclase", "gene_name": "si:ch211-132f19.7", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 8", "refseq_ac": "XP_688903", "gene_names_uniprotkb": "si:ch211-132f19.7", "gene_names_refseq": "si:ch211-132f19.7", "protein_names_uniprotkb": "adenylate cyclase; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 8", "tax_id": 7955, "disease": "", "pathway": " (dre:560410)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_688903.3. COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells., [UniProtKB, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TD24;X1WHD8", "ec_number_list": "4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FC63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCE4-1", "uniprot_id": "E7FCE4_DANRE", "mass": 104999.0, "length": 939, "protein_name": "Tyrosine-protein kinase transmembrane receptor ROR2", "gene_name": "ror2", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase transmembrane receptor ROR2", "refseq_ac": "XP_021327888", "gene_names_uniprotkb": "ror2", "gene_names_refseq": "ror2", "protein_names_uniprotkb": "Tyrosine-protein kinase transmembrane receptor ROR2", "protein_names_refseq": "tyrosine-protein kinase transmembrane receptor ROR2", "tax_id": 7955, "disease": "autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); brachydactyly type B1 (Disease Ontology:DOID:0110969); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dre:561183); (R-DRE-5140745)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T7B8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016055 Wnt signaling pathway;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FCE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCF4-1", "uniprot_id": "E7FCF4_DANRE", "mass": 31734.0, "length": 277, "protein_name": "Alkaline ceramidase", "gene_name": "acer2", "organism": "Zebrafish", "refseq_name": "alkaline ceramidase 2 isoform X1", "refseq_ac": "XP_002663077", "gene_names_uniprotkb": "acer2", "gene_names_refseq": "acer2", "protein_names_uniprotkb": "Alkaline ceramidase; 3.5.1.-", "protein_names_refseq": "alkaline ceramidase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331179); (R-DRE-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002663077.1. COMPLETENESS: full length., [RefSeq]; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RLY9", "ec_number_list": "3.5.1.-;3.5.1.23", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FCF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCM6-1", "uniprot_id": "E7FCM6_DANRE", "mass": 44952.0, "length": 390, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "si:dkey-199f5.8", "organism": "Zebrafish", "refseq_name": "beta-1,4-galactosyltransferase 3", "refseq_ac": "XP_684461", "gene_names_uniprotkb": "si:dkey-199f5.8", "gene_names_refseq": "si:dkey-199f5.8", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "beta-1,4-galactosyltransferase 3", "tax_id": 7955, "disease": "", "pathway": " (dre:556544)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_684461.3. COMPLETENESS: full length., [RefSeq]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UQP2", "ec_number_list": "2.4.1.-;2.4.1.90", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FCM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCN5-1", "uniprot_id": "E7FCN5_DANRE", "mass": 84519.0, "length": 768, "protein_name": "Integrin beta", "gene_name": "itgb2", "organism": "Zebrafish", "refseq_name": "integrin beta-2", "refseq_ac": "XP_686012", "gene_names_uniprotkb": "itgb2", "gene_names_refseq": "itgb2", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "integrin beta-2", "tax_id": 7955, "disease": "leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); coronary restenosis (Disease Ontology:DOID:4247); leukocyte adhesion deficiency (Disease Ontology:DOID:6612); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (dre:557797); (R-DRE-202733); (R-DRE-216083); (R-DRE-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 9, 2008 this sequence version replaced XP_686012.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TDC7", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FCN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCN8-1", "uniprot_id": "INTU_DANRE", "mass": 101132.0, "length": 915, "protein_name": "Protein inturned", "gene_name": "intu", "organism": "Zebrafish", "refseq_name": "protein inturned isoform X2", "refseq_ac": "XP_068078231", "gene_names_uniprotkb": "intu", "gene_names_refseq": "intu", "protein_names_uniprotkb": "Protein inturned; Inturned planar cell polarity effector homolog", "protein_names_refseq": "protein inturned isoform X2", "tax_id": 7955, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); orofaciodigital syndrome XVII (Disease Ontology:DOID:0080289)", "pathway": " (dre:100007575); (R-DRE-5610787)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23594743;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0009986 cell surface", "go_biological_process": "GO:0007399 nervous system development;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport;GO:0060173 limb development;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FCN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FCX4-1", "uniprot_id": "E7FCX4_DANRE", "mass": 94615.0, "length": 836, "protein_name": "Pre-rRNA-processing protein TSR1 homolog", "gene_name": "tsr1", "organism": "Zebrafish", "refseq_name": "pre-rRNA-processing protein TSR1 homolog", "refseq_ac": "NP_001032447", "gene_names_uniprotkb": "tsr1; fc52b09; wu:fc52b09; zgc:123319", "gene_names_refseq": "fc52b09; tsr1; wu:fc52b09; zgc:123319", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR1 homolog", "protein_names_refseq": "TSR1, 20S rRNA accumulation, homolog; pre-rRNA-processing protein TSR1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:325037); (R-DRE-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16109975;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042170.1, GDQH01001795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Jul 28, 2025 this sequence version replaced XP_005157625.1, NP_001032447.2., [RefSeq]; Required during maturation of the 40S ribosomal subunit in the nucleolus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3Q8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E7FCX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FD73-1", "uniprot_id": "E7FD73_DANRE", "mass": 44342.0, "length": 401, "protein_name": "Prostaglandin E2 receptor EP3 subtype", "gene_name": "ptger3", "organism": "Zebrafish", "refseq_name": "prostaglandin E2 receptor EP3 subtype isoform X1", "refseq_ac": "XP_017212135", "gene_names_uniprotkb": "ptger3", "gene_names_refseq": "ptger3", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP3 subtype; Prostanoid EP3 receptor", "protein_names_refseq": "prostaglandin E2 receptor EP3 subtype isoform X1", "tax_id": 7955, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); leiomyoma (Disease Ontology:DOID:127)", "pathway": " (dre:100000544); (R-DRE-391908); (R-DRE-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YZR3", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0060455 negative regulation of gastric acid secretion;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FD73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FD91-1", "uniprot_id": "E7FD91_DANRE", "mass": 53910.0, "length": 484, "protein_name": "RNA helicase", "gene_name": "ddx6", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent RNA helicase DDX6", "refseq_ac": "XP_684923", "gene_names_uniprotkb": "ddx6", "gene_names_refseq": "ddx6", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13; DEAD box protein 6", "protein_names_refseq": "probable ATP-dependent RNA helicase DDX6", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-430039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UUZ0;A0AC58HUN9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0009408 response to heat;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FD91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDA0-1", "uniprot_id": "E7FDA0_DANRE", "mass": 64121.0, "length": 557, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "galnt1", "organism": "Zebrafish", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 1", "refseq_ac": "XP_687472", "gene_names_uniprotkb": "galnt1", "gene_names_refseq": "galnt1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "polypeptide N-acetylgalactosaminyltransferase 1", "tax_id": 7955, "disease": "heart valve disease (Disease Ontology:DOID:4079)", "pathway": " (R-DRE-913709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_687472.2. COMPLETENESS: full length., [RefSeq]; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TDI1;A0AC58HJP6;A0AC58HJP8;A0AC58HJQ3", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FDA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDB3-1", "uniprot_id": "NANO1_DANRE", "mass": 24861.0, "length": 228, "protein_name": "Nanos homolog 1", "gene_name": "nanos1", "organism": "Zebrafish", "refseq_name": "nanos homolog 1", "refseq_ac": "NP_001292590", "gene_names_uniprotkb": "nanos1; wu:fb76c12", "gene_names_refseq": "fb76c12; fb93h11; fb98e07; nanos1; wu:fb76c12; wu:fb93h11; wu:fb98e07; wu:fq21a10", "protein_names_uniprotkb": "Nanos homolog 1", "protein_names_refseq": "nanos homolog 1; nanos-related; nos2", "tax_id": 7955, "disease": "spermatogenic failure 12 (Disease Ontology:DOID:0070171)", "pathway": " (dre:322903)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23228893;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: GDQQ01026987.1, SRR32588734.2418632.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Mar 26, 2015 this sequence version replaced XP_003199884.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data indicate that nanos3 function is required for the maintenance of germline stem cell (GSC), but not for their specification, and suggest that nanos2 and nanos3 are partially redundant in this role., [RefSeq, PubMed]; May act as a translational repressor which regulates translation of specific mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0060293 germ plasm", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FDB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDE0-1", "uniprot_id": "TM138_DANRE", "mass": 19234.0, "length": 162, "protein_name": "Transmembrane protein 138", "gene_name": "tmem138", "organism": "Zebrafish", "refseq_name": "transmembrane protein 138", "refseq_ac": "NP_001410775", "gene_names_uniprotkb": "tmem138", "gene_names_refseq": "tmem138", "protein_names_uniprotkb": "Transmembrane protein 138", "protein_names_refseq": "tmem138a; transmembrane protein 138", "tax_id": 7955, "disease": "Joubert syndrome 16 (Disease Ontology:DOID:0110985)", "pathway": " (dre:100332440)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22282472;22936720;23594743;25139857;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01040994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GFIL01040994.1 and EB908756.1. On Aug 16, 2023 this sequence version replaced XP_002666816.1., [RefSeq]; Required for ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7FDE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDL0-1", "uniprot_id": "E7FDL0_DANRE", "mass": 42814.0, "length": 379, "protein_name": "Somatostatin receptor type 2", "gene_name": "sstr2a", "organism": "Zebrafish", "refseq_name": "somatostatin receptor type 2", "refseq_ac": "XP_005170178", "gene_names_uniprotkb": "sstr2a", "gene_names_refseq": "sstr2a", "protein_names_uniprotkb": "Somatostatin receptor type 2", "protein_names_refseq": "somatostatin receptor type 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100333578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BHW4", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0071392 cellular response to estradiol stimulus;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FDL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDV9-1", "uniprot_id": "E7FDV9_DANRE", "mass": 93811.0, "length": 824, "protein_name": "Cysteine--tRNA ligase, cytoplasmic", "gene_name": "cars1", "organism": "Zebrafish", "refseq_name": "cysteine--tRNA ligase, cytoplasmic", "refseq_ac": "NP_001112372", "gene_names_uniprotkb": "cars1; cars; sb:cb71", "gene_names_refseq": "cars1; cars; sb:cb71", "protein_names_uniprotkb": "Cysteine--tRNA ligase, cytoplasmic; 6.1.1.16; Cysteinyl-tRNA synthetase", "protein_names_refseq": "cysteine--tRNA ligase, cytoplasmic", "tax_id": 7955, "disease": "", "pathway": " (dre:368284)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11748827;15520368;15590939;26278626;26469318;28934368;31669493;34697290;34872004;38806677", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01003065.1, SRR26395028.1067186.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Mar 7, 2008 this sequence version replaced XP_707456.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NI72", "ec_number_list": "6.1.1.16", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004817 cysteine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7FDV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FDX5-1", "uniprot_id": "LBX1B_DANRE", "mass": 29510.0, "length": 265, "protein_name": "Transcription factor LBX1b", "gene_name": "lbx1b", "organism": "Zebrafish", "refseq_name": "transcription factor LBX1b", "refseq_ac": "NP_001156784", "gene_names_uniprotkb": "lbx1b", "gene_names_refseq": "im:7139117; lbx1a; lbx1b", "protein_names_uniprotkb": "Transcription factor LBX1b; Ladybird homeobox 1b", "protein_names_refseq": "ladybird homeobox 1a; lbx1; transcription factor LBX1b", "tax_id": 7955, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (dre:793810)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19216761;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090687.1, CK706223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Jul 16, 2009 this sequence version replaced XP_001333647.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Transcription factor required for the development of hypaxial muscles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QS21", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0042692 muscle cell differentiation;GO:0060026 convergent extension", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FDX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FE05-1", "uniprot_id": "E7FE05_DANRE", "mass": 90036.0, "length": 802, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6ka5", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-5", "refseq_ac": "XP_693550", "gene_names_uniprotkb": "rps6ka5", "gene_names_refseq": "rps6ka5", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-5", "tax_id": 7955, "disease": "", "pathway": " (dre:565173); (R-DRE-198753); (R-DRE-199920); (R-DRE-375165)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_693550.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UVD1", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FE05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FEC4-1", "uniprot_id": "SUSD4_DANRE", "mass": 53453.0, "length": 484, "protein_name": "Sushi domain-containing protein 4", "gene_name": "susd4", "organism": "Zebrafish", "refseq_name": "sushi domain-containing protein 4 precursor", "refseq_ac": "NP_001306062", "gene_names_uniprotkb": "susd4", "gene_names_refseq": "susd4", "protein_names_uniprotkb": "Sushi domain-containing protein 4", "protein_names_refseq": "sushi domain-containing protein 4 precursor; sushi domain-containing protein 4", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "20348246;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01016411.1, GDQH01015726.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jan 26, 2016 this sequence version replaced XP_688793.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030449 regulation of complement activation;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E7FEC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FEG9-1", "uniprot_id": "E7FEG9_DANRE", "mass": 111867.0, "length": 991, "protein_name": "Glutamate receptor", "gene_name": "grik3", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 3 isoform X1", "refseq_ac": "XP_017206939", "gene_names_uniprotkb": "grik3", "gene_names_refseq": "grik3", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334689); (R-DRE-500657)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons., [UniProtKB, UniProtKB, UniProtKB]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist., [UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YST6", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FEG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FEW6-1", "uniprot_id": "E7FEW6_DANRE", "mass": 71751.0, "length": 653, "protein_name": "dual-specificity kinase", "gene_name": "tesk1b", "organism": "Zebrafish", "refseq_name": "dual specificity testis-specific protein kinase 1 isoform X1", "refseq_ac": "XP_021333467", "gene_names_uniprotkb": "tesk1b", "gene_names_refseq": "tesk1b", "protein_names_uniprotkb": "dual-specificity kinase; 2.7.12.1", "protein_names_refseq": "dual specificity testis-specific protein kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559449)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PPL6", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FEW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFA5-1", "uniprot_id": "E7FFA5_DANRE", "mass": 152783.0, "length": 1324, "protein_name": "Angiotensin-converting enzyme", "gene_name": "ace", "organism": "Zebrafish", "refseq_name": "angiotensin-converting enzyme", "refseq_ac": "XP_694336", "gene_names_uniprotkb": "ace", "gene_names_refseq": "ace", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 3.4.-.-", "protein_names_refseq": "angiotensin-converting enzyme", "tax_id": 7955, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoidosis (Disease Ontology:DOID:11335); pyelonephritis (Disease Ontology:DOID:11400); diabetic angiopathy (Disease Ontology:DOID:11713); allergic disease (Disease Ontology:DOID:1205); leukemia (Disease Ontology:DOID:1240); hepatitis A (Disease Ontology:DOID:12549); uveitis (Disease Ontology:DOID:13141); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); mitral valve disease (Disease Ontology:DOID:61); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); polycythemia (Disease Ontology:DOID:8432); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); diastolic heart failure (Disease Ontology:DOID:9775); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (dre:565980); (R-DRE-2022377)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_694336.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T834", "ec_number_list": "3.4.-.-", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0008241 peptidyl-dipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0003084 positive regulation of systemic arterial blood pressure;GO:0060730 regulation of intestinal epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FFA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFB7-1", "uniprot_id": "E7FFB7_DANRE", "mass": 87105.0, "length": 756, "protein_name": "[histone H3]-lysine(27) N-trimethyltransferase", "gene_name": "ezh1", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase EZH1", "refseq_ac": "NP_001035072", "gene_names_uniprotkb": "ezh1; si:ch211-250i3.1; zgc:136829", "gene_names_refseq": "ezh1; si:ch211-250i3.1; zgc:136829", "protein_names_uniprotkb": "[histone H3]-lysine(27) N-trimethyltransferase; 2.1.1.356", "protein_names_refseq": "enhancer of zeste homolog 1; histone-lysine N-methyltransferase EZH1", "tax_id": 7955, "disease": "", "pathway": " (dre:664754); (R-DRE-212300)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18231586;24240475;26469318;26857418;27145952;30867490;32051014;34143974;34735227;36208295", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On or before Jan 28, 2011 this sequence version replaced XP_002661252.1, NP_001035072.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development. Publication Status: Online-Only, [RefSeq, PubMed]; Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N8R5", "ec_number_list": "2.1.1.356", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046976 histone H3K27 methyltransferase activity;GO:0140951 histone H3K27 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0060844 arterial endothelial cell fate commitment;GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E7FFB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFC4-1", "uniprot_id": "E7FFC4_DANRE", "mass": 40471.0, "length": 373, "protein_name": "Ferroptosis suppressor protein 1", "gene_name": "aifm2", "organism": "Zebrafish", "refseq_name": "ferroptosis suppressor protein 1", "refseq_ac": "NP_001186939", "gene_names_uniprotkb": "aifm2; im:6904058", "gene_names_refseq": "aifm2; im:6904058", "protein_names_uniprotkb": "Ferroptosis suppressor protein 1; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death", "protein_names_refseq": "AIF family member 2; apoptosis inducing factor mitochondria associated 2; apoptosis-inducing factor, mitochondrion-associated, 2; ferroptosis suppressor protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:557507)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21390203;26469318;27086301;28252024;28323199;38181896", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01023021.1, GDQH01019365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1, EH541631.1, EH446603.1 and EH577976.1., [RefSeq]; Putative FAD-dependent oxidoreductase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NXH1", "ec_number_list": "1.6.5.2", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004174 electron-transferring-flavoprotein dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0008637 apoptotic mitochondrial changes;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E7FFC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFK0-1", "uniprot_id": "E7FFK0_DANRE", "mass": 143672.0, "length": 1249, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp8b1", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase IC", "refseq_ac": "XP_001920510", "gene_names_uniprotkb": "atp8b1", "gene_names_refseq": "atp8b1", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase IC", "tax_id": 7955, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); progressive familial intrahepatic cholestasis 1 (Disease Ontology:DOID:0070226); intrahepatic cholestasis of pregnancy 1 (Disease Ontology:DOID:0070228); benign recurrent intrahepatic cholestasis 1 (Disease Ontology:DOID:0070231); intrahepatic cholestasis (Disease Ontology:DOID:1852)", "pathway": " (dre:100148342); (R-DRE-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001920510.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QKG0;E9QJN9", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FFK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFQ7-1", "uniprot_id": "E7FFQ7_DANRE", "mass": 141902.0, "length": 1275, "protein_name": "3.4.17.22; Carboxypeptidase D, b", "gene_name": "cpdb", "organism": "Zebrafish", "refseq_name": "carboxypeptidase D, b", "refseq_ac": "NP_001315329", "gene_names_uniprotkb": "cpdb; zgc:152928", "gene_names_refseq": "cpdb; zgc:152928", "protein_names_uniprotkb": "3.4.17.22; Carboxypeptidase D, b", "protein_names_refseq": "carboxypeptidase D, b", "tax_id": 7955, "disease": "", "pathway": " (dre:555848)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22915831;27189481;32179471;34619175", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01021481.1, SRR26395064.1976397.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505381, SAMEA3505385 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Jun 25, 2025 this sequence version replaced NP_001315329.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PA92", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E7FFQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FFT8-1", "uniprot_id": "E7FFT8_DANRE", "mass": 98935.0, "length": 868, "protein_name": "Discoidin domain-containing receptor 2", "gene_name": "ddr2a", "organism": "Zebrafish", "refseq_name": "discoidin domain-containing receptor 2 isoform X1", "refseq_ac": "XP_073761977", "gene_names_uniprotkb": "ddr2a", "gene_names_refseq": "ddr2a", "protein_names_uniprotkb": "Discoidin domain-containing receptor 2; 2.7.10.1; CD167 antigen-like family member B; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10", "protein_names_refseq": "discoidin domain-containing receptor 2 isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spondylometaepiphyseal dysplasia, short limb-hand type (Disease Ontology:DOID:0112196); stomach cancer (Disease Ontology:DOID:10534); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:556380); (R-DRE-3000171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BDU8;A0AC58FX42;A0AC58FX85", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0038062 protein tyrosine kinase collagen receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001503 ossification;GO:0010715 regulation of extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E7FFT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E7FG90-1", "uniprot_id": "E7FG90_DANRE", "mass": 53474.0, "length": 485, "protein_name": "Alpha-1A adrenergic receptor", "gene_name": "adra1aa", "organism": "Zebrafish", "refseq_name": "alpha-1A adrenergic receptor", "refseq_ac": "NP_001311383", "gene_names_uniprotkb": "adra1aa; adra1a; fc18h12; wu:fc18h12", "gene_names_refseq": "adra1aa; adra1a; fc18h12; wu:fc18h12", "protein_names_uniprotkb": "Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor", "protein_names_refseq": "adrenergic, alpha-1A-, receptor; adrenergic, alpha-1Aa, receptor; adrenoceptor alpha 1A; alpha-1A adrenergic receptor", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:798498); (R-DRE-390696); (R-DRE-416476); (R-DRE-416482)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "15196956;24080366;26426478;30569449;31780714;32094353;32179471;32209227;33600148", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01025257.1, SRR32588726.10675508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476738, SAMEA4476739 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On May 5, 2016 this sequence version replaced XP_001338938.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P8T8;A0AC58G8F2", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "E7FG90-1", "record_type": "protein" } ]