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UniProtKB, UniProtKB]; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:1903979 negative regulation of microglial cell activation;GO:1903334 positive regulation of protein folding;GO:0002265 astrocyte activation involved in immune response;GO:0010595 positive regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RQZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S064-1", "uniprot_id": "F1S064_PIG", "mass": 82412.0, "length": 783, "protein_name": "Sp3 transcription factor", "gene_name": "SP3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sp3 transcription factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153372); (R-SSC-3232118)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RR22-1", "uniprot_id": "F1RR22_PIG", "mass": 122821.0, "length": 1104, "protein_name": "Formin like 1", "gene_name": "FMNL1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FMNL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Formin like 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5663220); (R-SSC-9013148); (R-SSC-9013149)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding;GO:0051015 actin filament binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0022604 regulation of cell morphogenesis;GO:0016477 cell migration;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RR22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RQY4-1", "uniprot_id": "F1RQY4_PIG", "mass": 84910.0, "length": 727, "protein_name": "Nucleolar transcription factor 1", "gene_name": "UBTF", "organism": "Pig", "refseq_name": "nucleolar transcription factor 1 isoform X3", "refseq_ac": "XP_020922535", "gene_names_uniprotkb": "UBTF", "gene_names_refseq": "UBTF", "protein_names_uniprotkb": "Nucleolar transcription factor 1; Upstream-binding factor 1", "protein_names_refseq": "nucleolar transcription factor 1 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-73728); (R-SSC-73762); (R-SSC-73772); (R-SSC-73863)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480K6L0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0097110 scaffold protein binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005634 nucleus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006360 transcription by RNA polymerase I;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RQY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RRX1-1", "uniprot_id": "F1RRX1_PIG", "mass": 22432.0, "length": 199, "protein_name": "Lipocalin 2", "gene_name": "LCN2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LCN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipocalin 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BJ65;A0A480UMD1", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RRX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S3G4-1", "uniprot_id": "F1S3G4_PIG", "mass": 44586.0, "length": 393, "protein_name": "F-box/LRR-repeat protein 12", "gene_name": "FBXL12", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FBXL12", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100513198)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S3G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RS71-1", "uniprot_id": "F1RS71_PIG", "mass": 87677.0, "length": 785, "protein_name": "Protein arginine methyltransferase 9", "gene_name": "PRMT9", "organism": "Pig", "refseq_name": "putative protein arginine N-methyltransferase 9 isoform X2", "refseq_ac": "XP_020957182", "gene_names_uniprotkb": "PRMT9", "gene_names_refseq": "PRMT9", "protein_names_uniprotkb": "Protein arginine methyltransferase 9", "protein_names_refseq": "putative protein arginine N-methyltransferase 9 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521981)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016274 protein-arginine N-methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0006338 chromatin remodeling;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RS71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RQL2-1", "uniprot_id": "F1RQL2_PIG", "mass": 96473.0, "length": 854, "protein_name": "Dual specificity protein kinase TTK", "gene_name": "TTK", "organism": "Pig", "refseq_name": "dual specificity protein kinase TTK isoform X1", "refseq_ac": "XP_020947710", "gene_names_uniprotkb": "TTK", "gene_names_refseq": "TTK", "protein_names_uniprotkb": "Dual specificity protein kinase TTK; 2.7.12.1", "protein_names_refseq": "dual specificity protein kinase TTK isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157649)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0098813 nuclear chromosome segregation;GO:0000280 nuclear division;GO:0033316 meiotic spindle assembly checkpoint signaling;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RQL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S2V2-1", "uniprot_id": "F1S2V2_PIG", "mass": 22616.0, "length": 205, "protein_name": "TPD52 like 1", "gene_name": "TPD52L1", "organism": "Pig", "refseq_name": "tumor protein D53 isoform X2", "refseq_ac": "XP_020944366", "gene_names_uniprotkb": "TPD52L1", "gene_names_refseq": "TPD52L1", "protein_names_uniprotkb": "TPD52 like 1", "protein_names_refseq": "tumor protein D53 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-432722)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0000086 G2/M transition of mitotic cell cycle;GO:2001235 positive regulation of apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S2V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S193-1", "uniprot_id": "F1S193_PIG", "mass": 36829.0, "length": 318, "protein_name": "Death effector domain-containing protein", "gene_name": "DEDD", "organism": "Pig", "refseq_name": "death effector domain-containing protein", "refseq_ac": "XP_001927399", "gene_names_uniprotkb": "DEDD", "gene_names_refseq": "DEDD", "protein_names_uniprotkb": "Death effector domain-containing protein", "protein_names_refseq": "death effector domain-containing protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:100156474)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1VT31;F1S194;F1S195", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0006351 DNA-templated transcription;GO:0042981 regulation of apoptotic process;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RVQ5-1", "uniprot_id": "F1RVQ5_PIG", "mass": 122999.0, "length": 1066, "protein_name": "Dishevelled associated activator of morphosis 2", "gene_name": "DAAM2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DAAM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dishevelled associated activator of morphosis 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030335 positive regulation of cell migration;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RVQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RZR2-1", "uniprot_id": "F1RZR2_PIG", "mass": 23463.0, "length": 211, "protein_name": "Bcl-2 homologous antagonist/killer", "gene_name": "BAK1", "organism": "Pig", "refseq_name": "bcl-2 homologous antagonist/killer isoform X2", "refseq_ac": "XP_001928182", "gene_names_uniprotkb": "BAK1", "gene_names_refseq": "BAK1", "protein_names_uniprotkb": "Bcl-2 homologous antagonist/killer; 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1.1.1.62", "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase 13 isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RW28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZLN5-1", "uniprot_id": "A0A286ZLN5_PIG", "mass": 52635.0, "length": 465, "protein_name": "Kynureninase", "gene_name": "KYNU", "organism": "Pig", "refseq_name": "kynureninase isoform X3", "refseq_ac": "XP_020931494", "gene_names_uniprotkb": "KYNU", "gene_names_refseq": "KYNU", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase", "protein_names_refseq": "kynureninase isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-71240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0030429 kynureninase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006569 L-tryptophan catabolic process;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZLN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S467-1", "uniprot_id": "F1S467_PIG", "mass": 45682.0, "length": 418, "protein_name": "NADPH:quinone reductase", "gene_name": "VAT1L", "organism": 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Erythrocyte membrane protein band 4.1-like 5", "protein_names_refseq": "band 4.1-like protein 5 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6794361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZYD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1SHD5-1", "uniprot_id": "A0A4X1SHD5_PIG", "mass": 30601.0, "length": 276, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase", "gene_name": "HSD17B12", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSD17B12", "gene_names_refseq": "", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase; 1.1.1.330; 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100312972); (R-SSC-193048); (R-SSC-75876)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2R2V8", "ec_number_list": "", "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity;GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1SHD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AY99-1", "uniprot_id": "A0A287AY99_PIG", "mass": 97333.0, "length": 860, "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AGO2; EIF2C2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein argonaute-2; 3.1.26.n2; Argonaute2; Eukaryotic translation initiation factor 2C 2; Protein slicer; eIF-2C 2; eIF2C 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-203927); (R-SSC-426486); (R-SSC-426496); (R-SSC-5578749)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0000340 RNA 7-methylguanosine cap binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0070062 extracellular exosome", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045766 positive regulation of angiogenesis;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AY99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B6A9-1", "uniprot_id": "A0A287B6A9_PIG", "mass": 132435.0, "length": 1181, "protein_name": "Rho guanine nucleotide exchange factor 2", "gene_name": "ARHGEF2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARHGEF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-193648); (R-SSC-416482); (R-SSC-8980692); (R-SSC-9013026)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005874 microtubule;GO:0005923 bicellular tight junction;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:0051301 cell division;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B6A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S4Q2-1", "uniprot_id": "F1S4Q2_PIG", "mass": 26741.0, "length": 234, "protein_name": "Family with sequence similarity 204 member A", "gene_name": "FAM204A", "organism": "Pig", "refseq_name": "protein FAM204A", "refseq_ac": "NP_001172100", "gene_names_uniprotkb": "FAM204A", "gene_names_refseq": "C10orf84; C14H10orf84; FAM204A", "protein_names_uniprotkb": "Family with sequence similarity 204 member A", "protein_names_refseq": "protein FAM204A", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152540)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1SY09", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S4Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S588-1", "uniprot_id": "F1S588_PIG", "mass": 28805.0, "length": 260, "protein_name": "Translocase of inner mitochondrial membrane 29", "gene_name": "TIMM29", "organism": "Pig", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim29", "refseq_ac": "XP_003123253", "gene_names_uniprotkb": "TIMM29", "gene_names_refseq": "TIMM29", "protein_names_uniprotkb": "Translocase of inner mitochondrial membrane 29", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim29", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522007)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042721 TIM22 mitochondrial import inner membrane insertion complex;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S588-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S3W7-1", "uniprot_id": "F1S3W7_PIG", "mass": 54126.0, "length": 490, "protein_name": "EF-hand calcium binding domain 14", "gene_name": "EFCAB14", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EFCAB14", "gene_names_refseq": "", "protein_names_uniprotkb": "EF-hand calcium binding domain 14", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S3W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S4Q6-1", "uniprot_id": "F1S4Q6_PIG", "mass": 120828.0, "length": 1049, "protein_name": "CCAAT/enhancer-binding protein zeta", "gene_name": "CEBPZ", "organism": "Pig", "refseq_name": "CCAAT/enhancer-binding protein zeta", "refseq_ac": 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"reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S5Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0A0MY60-1", "uniprot_id": "A0A0A0MY60_PIG", "mass": 91005.0, "length": 799, "protein_name": "Signal transducer and activator of transcription", "gene_name": "STAT5A", "organism": "Pig", "refseq_name": "signal transducer and activator of transcription 5A isoform X1", "refseq_ac": "XP_020921906", "gene_names_uniprotkb": "STAT5A", "gene_names_refseq": "STAT5A", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 5A isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1251985); (R-SSC-1266695); (R-SSC-1433557); (R-SSC-186763); (R-SSC-512988); (R-SSC-8854691); (R-SSC-8983432); (R-SSC-8985947); (R-SSC-9020558); (R-SSC-9020958)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0030222 eosinophil differentiation;GO:0038043 interleukin-5-mediated signaling pathway;GO:0038156 interleukin-3-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0A0MY60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZFW3-1", "uniprot_id": "A0A286ZFW3_PIG", "mass": 38275.0, "length": 345, "protein_name": "Beta-2-glycoprotein 1", "gene_name": "APOH", "organism": "Pig", "refseq_name": "beta-2-glycoprotein 1 isoform X1", "refseq_ac": "XP_003131314", "gene_names_uniprotkb": "APOH", "gene_names_refseq": "APOH", "protein_names_uniprotkb": "Beta-2-glycoprotein 1; Apolipoprotein H; Beta-2-glycoprotein I", "protein_names_refseq": "beta-2-glycoprotein 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522100); (R-SSC-114608)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1SSS9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0035473 lipase binding;GO:0060230 lipoprotein lipase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0051918 negative regulation of fibrinolysis;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZFW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZIE8-1", "uniprot_id": "A0A286ZIE8_PIG", "mass": 33026.0, "length": 298, "protein_name": "ADP/ATP translocase", "gene_name": "SLC25A4", "organism": "Pig", "refseq_name": "ADP/ATP translocase 1", "refseq_ac": "XP_003133393", "gene_names_uniprotkb": "SLC25A4", "gene_names_refseq": "SLC25A4", "protein_names_uniprotkb": "ADP/ATP translocase; ADP,ATP carrier protein", "protein_names_refseq": "ADP/ATP translocase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517196); (R-SSC-1268020); (R-SSC-166187); (R-SSC-83936)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the exchange of ADP and ATP across the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005471 ATP:ADP antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0046902 regulation of mitochondrial membrane permeability;GO:0060546 negative regulation of necroptotic process;GO:1990845 adaptive thermogenesis;GO:0140021 mitochondrial ADP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZIE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZIG4-1", "uniprot_id": "A0A286ZIG4_PIG", "mass": 41908.0, "length": 382, "protein_name": "Pyridoxal kinase", "gene_name": "PDXK", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PDXK", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6798695); (R-SSC-964975)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively. PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031403 lithium ion binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZIG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZIW7-1", "uniprot_id": "A0A286ZIW7_PIG", "mass": 52664.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A23", "gene_name": "SLC25A23", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC25A23", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A23; Short calcium-binding mitochondrial carrier protein 3; Solute carrier family 25 member 23", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways. Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0140988 ADP:phosphate antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0036444 calcium import into the mitochondrion;GO:0051561 positive regulation of mitochondrial calcium ion concentration;GO:0015867 ATP transport;GO:1900069 regulation of cellular hyperosmotic salinity response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZIW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZJ80-1", "uniprot_id": "A0A286ZJ80_PIG", "mass": 50932.0, "length": 458, "protein_name": "Retinoic acid receptor gamma", "gene_name": "RARG", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RARG", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor gamma", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032526 response to retinoic acid;GO:0048384 retinoic acid receptor signaling pathway;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZJ80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZKE4-1", "uniprot_id": "A0A286ZKE4_PIG", "mass": 47630.0, "length": 425, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "CLP1", "organism": "Pig", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": "XP_003122764", "gene_names_uniprotkb": "CLP1", "gene_names_refseq": "CLP1", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100520541); (R-SSC-72187); (R-SSC-73856); (R-SSC-77595); (R-SSC-9770562)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing., [UniProtKB, HAMAP]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZKE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480I6L4-1", "uniprot_id": "A0A480I6L4_PIG", "mass": 121891.0, "length": 1063, "protein_name": "Unconventional myosin-Ic", "gene_name": "MYO1C", "organism": "Pig", "refseq_name": "unconventional myosin-Ic isoform X4", "refseq_ac": "XP_020923218", "gene_names_uniprotkb": "MYO1C", "gene_names_refseq": "MYO1C", "protein_names_uniprotkb": "Unconventional myosin-Ic; Myosin I beta", "protein_names_refseq": "unconventional myosin-Ic isoform X4", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2029482); (R-SSC-5250924)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2RI50;A0A8D0IWP4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0031410 cytoplasmic vesicle;GO:0032587 ruffle membrane;GO:0016459 myosin complex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030335 positive regulation of cell migration;GO:0006612 protein targeting to membrane;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A480I6L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZLU2-1", "uniprot_id": "A0A286ZLU2_PIG", "mass": 32318.0, "length": 286, "protein_name": "3-hydroxyanthranilate 3,4-dioxygenase", "gene_name": "HAAO", "organism": "Pig", "refseq_name": "3-hydroxyanthranilate 3,4-dioxygenase isoform X1", "refseq_ac": "XP_020941329", "gene_names_uniprotkb": "HAAO", "gene_names_refseq": "HAAO", "protein_names_uniprotkb": "3-hydroxyanthranilate 3,4-dioxygenase; 1.13.11.6; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD", "protein_names_refseq": "3-hydroxyanthranilate 3,4-dioxygenase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-71240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0010043 response to zinc ion;GO:0070050 neuron cellular homeostasis;GO:0046686 response to cadmium ion;GO:0019805 quinolinate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZLU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZM09-1", "uniprot_id": "A0A286ZM09_PIG", "mass": 147037.0, "length": 1270, "protein_name": "Protein fantom", "gene_name": "RPGRIP1L", "organism": "Pig", "refseq_name": "protein fantom isoform X1", "refseq_ac": "XP_020952758", "gene_names_uniprotkb": "RPGRIP1L", "gene_names_refseq": "RPGRIP1L", "protein_names_uniprotkb": "Protein fantom; Nephrocystin-8; RPGR-interacting protein 1-like protein", "protein_names_refseq": "protein fantom isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100624004); (R-SSC-5610787); (R-SSC-5620912)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031870 thromboxane A2 receptor binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0046548 retinal rod cell development;GO:1905515 non-motile cilium assembly;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZM09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZMD0-1", "uniprot_id": "A0A286ZMD0_PIG", "mass": 78355.0, "length": 699, "protein_name": "UV radiation resistance associated", "gene_name": "UVRAG", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UVRAG", "gene_names_refseq": "", "protein_names_uniprotkb": "UV radiation resistance associated", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1632852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0051684 maintenance of Golgi location;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZMD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ALL2-1", "uniprot_id": "A0A287ALL2_PIG", "mass": 49938.0, "length": 436, "protein_name": "Telomeric repeat-binding factor", "gene_name": "TERF1", "organism": "Pig", "refseq_name": "telomeric repeat-binding factor 1 isoform X1", "refseq_ac": "XP_005663085", "gene_names_uniprotkb": "TERF1", "gene_names_refseq": "TERF1", "protein_names_uniprotkb": "Telomeric repeat-binding factor", "protein_names_refseq": "telomeric repeat-binding factor 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516798); (R-SSC-110330); (R-SSC-110331); (R-SSC-171306); (R-SSC-171319); (R-SSC-174411); (R-SSC-174414); (R-SSC-174417); (R-SSC-174430); (R-SSC-174437); (R-SSC-2559586); (R-SSC-9670095)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003691 double-stranded telomeric DNA binding;GO:0008301 DNA binding, bending;GO:0098505 G-rich strand telomeric DNA binding;GO:0003720 telomerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0000783 nuclear telomere cap complex;GO:0005730 nucleolus;GO:0016604 nuclear body", "go_biological_process": "GO:0051301 cell division;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0061820 telomeric D-loop disassembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ALL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B3A4-1", "uniprot_id": "A0A287B3A4_PIG", "mass": 270684.0, "length": 2397, "protein_name": "Spectrin beta chain", "gene_name": "SPTBN2", "organism": "Pig", "refseq_name": "spectrin beta chain, non-erythrocytic 2 isoform X1", "refseq_ac": "XP_020938428", "gene_names_uniprotkb": "SPTBN2", "gene_names_refseq": "SPTBN2", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "spectrin beta chain, non-erythrocytic 2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:110259235); (R-SSC-2132295); (R-SSC-375165); (R-SSC-5673001); (R-SSC-6807878)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Probably plays an important role in neuronal membrane skeleton., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005543 phospholipid binding;GO:0051015 actin filament binding;GO:0098918 structural constituent of synapse", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0008091 spectrin;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0051693 actin filament capping;GO:0030036 actin cytoskeleton organization;GO:0099150 regulation of postsynaptic specialization assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B3A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BDN2-1", "uniprot_id": "A0A287BDN2_PIG", "mass": 274550.0, "length": 2365, "protein_name": "Spectrin beta chain", "gene_name": "SPTBN1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPTBN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-375165); 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Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. 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Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. 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sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0017053 transcription repressor complex;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045600 positive regulation of fat cell differentiation;GO:0007417 central nervous system development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZSC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZSI3-1", "uniprot_id": "A0A286ZSI3_PIG", "mass": 78643.0, "length": 709, "protein_name": "Nicastrin", "gene_name": "NCSTN", "organism": "Pig", "refseq_name": "nicastrin isoform X1", "refseq_ac": "XP_001928821", "gene_names_uniprotkb": "NCSTN", "gene_names_refseq": "NCSTN", "protein_names_uniprotkb": "Nicastrin", "protein_names_refseq": "nicastrin isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100156098); (R-SSC-1251985); (R-SSC-193692); (R-SSC-3928665); (R-SSC-6798695); (R-SSC-9839383)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8D1I1Z1", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding;GO:0061133 endopeptidase activator activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0016485 protein processing;GO:0031293 membrane protein intracellular domain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZSI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AFT2-1", "uniprot_id": "A0A287AFT2_PIG", "mass": 45635.0, "length": 404, "protein_name": "L-Fucosyltransferase", "gene_name": "FUT2A", "organism": "Pig", "refseq_name": "galactoside 2-alpha-L-fucosyltransferase 2 isoform X1", "refseq_ac": "XP_013854049", "gene_names_uniprotkb": "FUT2A", "gene_names_refseq": "FUT2A", "protein_names_uniprotkb": "L-Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "galactoside 2-alpha-L-fucosyltransferase 2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100524201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AFT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZT06-1", "uniprot_id": "A0A286ZT06_PIG", "mass": 120560.0, "length": 1079, "protein_name": "Adenylate cyclase type 7", "gene_name": "ADCY7", "organism": "Pig", "refseq_name": "adenylate cyclase type 7 isoform X1", "refseq_ac": "XP_020949858", "gene_names_uniprotkb": "ADCY7", "gene_names_refseq": "ADCY7", "protein_names_uniprotkb": "Adenylate cyclase type 7; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 7 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100620994); (R-SSC-163615); (R-SSC-170660); (R-SSC-170670); (R-SSC-418597); (R-SSC-5610787)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a. Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP. Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome. It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells., [UniProtKB, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106408 diadenylate cyclase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0071361 cellular response to ethanol;GO:1900016 negative regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZT06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AKR1-1", "uniprot_id": "A0A287AKR1_PIG", "mass": 115947.0, "length": 1023, "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "IFIH1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IFIH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced helicase C domain-containing protein 1; 3.6.4.13; Helicase with 2 CARD domains; Melanoma differentiation-associated protein 5; RIG-I-like receptor 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5689880)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AKR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AWT3-1", "uniprot_id": "A0A287AWT3_PIG", "mass": 41611.0, "length": 373, "protein_name": "E3 ubiquitin-protein ligase RNF34", "gene_name": "RNF34", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNF34", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF34; 2.3.2.27; RING finger protein 34; RING-type E3 ubiquitin transferase RNF34", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6804757); (R-SSC-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031625 ubiquitin protein ligase binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0070417 cellular response to cold;GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;GO:2000374 regulation of oxygen metabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AWT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B5Q4-1", "uniprot_id": "A0A287B5Q4_PIG", "mass": 130140.0, "length": 1199, "protein_name": "Reticulon", "gene_name": "RTN4", "organism": "Pig", "refseq_name": "reticulon-4 isoform 1", "refseq_ac": "NP_001362314", "gene_names_uniprotkb": "RTN4", "gene_names_refseq": "RTN4", "protein_names_uniprotkb": "Reticulon", "protein_names_refseq": "reticulon-4 isoform 1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-193634)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0050821 protein stabilization;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B5Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZTG3-1", "uniprot_id": "A0A286ZTG3_PIG", "mass": 52692.0, "length": 500, "protein_name": "Actin nucleation-promoting factor WAS", "gene_name": "WAS", "organism": "Pig", "refseq_name": "wiskott-Aldrich syndrome protein", "refseq_ac": "XP_020935720", "gene_names_uniprotkb": "WAS", "gene_names_refseq": "WAS", "protein_names_uniprotkb": "Actin nucleation-promoting factor WAS", "protein_names_refseq": "wiskott-Aldrich syndrome protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:445527)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005911 cell-cell junction;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0006952 defense response;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZTG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZTI9-1", "uniprot_id": "A0A286ZTI9_PIG", "mass": 38217.0, "length": 334, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "gene_name": "B3GAT1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "B3GAT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; 2.4.1.135", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1971475)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.2, "record_id": "A0A286ZTI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZTQ8-1", "uniprot_id": "A0A286ZTQ8_PIG", "mass": 98308.0, "length": 902, "protein_name": "RAB11 family interacting protein 3", "gene_name": "RAB11FIP3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAB11FIP3", "gene_names_refseq": "", "protein_names_uniprotkb": "RAB11 family interacting protein 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5620916)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005813 centrosome;GO:0032588 trans-Golgi network membrane;GO:0030666 endocytic vesicle membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0070164 negative regulation of adiponectin secretion;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0043001 Golgi to plasma membrane protein transport;GO:0032456 endocytic recycling;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZTQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZUD5-1", "uniprot_id": "A0A286ZUD5_PIG", "mass": 14860.0, "length": 136, "protein_name": "SNARE-associated protein Snapin", "gene_name": "SNAPIN", "organism": "Pig", "refseq_name": "SNARE-associated protein Snapin", "refseq_ac": "NP_001230415", "gene_names_uniprotkb": "SNAPIN", "gene_names_refseq": "SNAPIN", "protein_names_uniprotkb": "SNARE-associated protein Snapin; Biogenesis of lysosome-related organelles complex 1 subunit 7", "protein_names_refseq": "SNARE-associated protein Snapin", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154273); (R-SSC-432722)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29577951;32543654", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling., [UniProtKB, UniProtKB]; The porcine reproductive and respiratory syndrome virus GP5 and M proteins can interact with cellular Snapin. Snapin knock-down suggests these interactions could be important in the porcine reproductive and respiratory syndrome virus lifecycle. GP5 and M proteins may interact with Snapin to exploit its roles in intracellular transport and membrane fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1VZY6", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm;GO:0001669 acrosomal vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0010977 negative regulation of neuron projection development;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A286ZUD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZUS8-1", "uniprot_id": "A0A286ZUS8_PIG", "mass": 29452.0, "length": 263, "protein_name": "Retinol dehydrogenase 10", "gene_name": "RDH10", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RDH10", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinol dehydrogenase 10; 1.1.1.300", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2453902); (R-SSC-5365859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042574 retinal metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZUS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZUT3-1", "uniprot_id": "A0A286ZUT3_PIG", "mass": 20585.0, "length": 183, "protein_name": "Ras-related protein Rap-2", "gene_name": "RAP2A", "organism": "Pig", "refseq_name": "ras-related protein Rap-2a", "refseq_ac": "XP_020921475", "gene_names_uniprotkb": "RAP2A", "gene_names_refseq": "RAP2A", "protein_names_uniprotkb": "Ras-related protein Rap-2", "protein_names_refseq": "ras-related protein Rap-2a", "tax_id": 9823, "disease": "", "pathway": " (ssc:100155367)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030335 positive regulation of cell migration;GO:0048814 regulation of dendrite morphogenesis;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZUT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BG95-1", "uniprot_id": "A0A287BG95_PIG", "mass": 225597.0, "length": 1996, "protein_name": "Chromodomain helicase DNA binding protein 3", "gene_name": "CHD3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHD3", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromodomain helicase DNA binding protein 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3214815); (R-SSC-4551638); (R-SSC-6804758); (R-SSC-73762); (R-SSC-8943724); (R-SSC-9937850); (R-SSC-9940951)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016605 PML body", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007098 centrosome cycle;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BG95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZV22-1", "uniprot_id": "A0A286ZV22_PIG", "mass": 83148.0, "length": 785, "protein_name": "SIX homeobox 4", "gene_name": "SIX4", "organism": "Pig", "refseq_name": "homeobox protein SIX4", "refseq_ac": "NP_001231543", "gene_names_uniprotkb": "SIX4", "gene_names_refseq": "SIX4", "protein_names_uniprotkb": "SIX homeobox 4", "protein_names_refseq": "homeobox protein SIX4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0061055 myotome development;GO:0061197 fungiform papilla morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZV22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZV90-1", "uniprot_id": "A0A286ZV90_PIG", "mass": 95449.0, "length": 887, "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "gene_name": "PAN3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PAN3", "gene_names_refseq": "", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-429947)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A., [UniProtKB, UniProtKB, UniProtKB]; Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation., [UniProtKB, UniProtKB, UniProtKB]; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"uniprot_id": "A0A286ZV95_PIG", "mass": 24911.0, "length": 219, "protein_name": "Transmembrane p24 trafficking protein 10", "gene_name": "TMED10", "organism": "Pig", "refseq_name": "transmembrane emp24 domain-containing protein 10", "refseq_ac": "XP_001926746", "gene_names_uniprotkb": "TMED10", "gene_names_refseq": "TMED10", "protein_names_uniprotkb": "Transmembrane p24 trafficking protein 10", "protein_names_refseq": "transmembrane emp24 domain-containing protein 10", "tax_id": 9823, "disease": "", "pathway": " (ssc:100158015); (R-SSC-204005); (R-SSC-5694530); (R-SSC-6807878); (R-SSC-6811434)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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"GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045055 regulated exocytosis;GO:0050714 positive regulation of protein secretion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZV95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZVB5-1", "uniprot_id": "A0A286ZVB5_PIG", "mass": 49139.0, "length": 435, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7", "gene_name": "MAP2K7", "organism": "Pig", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 7 isoform X4", "refseq_ac": "XP_003354087", "gene_names_uniprotkb": "MAP2K7", "gene_names_refseq": "MAP2K7", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 7; 2.7.12.2; JNK-activating kinase 2; MAPK/ERK kinase 7; c-Jun N-terminal kinase kinase 2", "protein_names_refseq": "dual specificity mitogen-activated protein kinase kinase 7 isoform X4", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008545 JUN kinase kinase activity;GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0034612 response to tumor necrosis factor;GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZVB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZWH4-1", "uniprot_id": "A0A286ZWH4_PIG", "mass": 50491.0, "length": 460, "protein_name": "Transcription factor AP-2 beta", "gene_name": "TFAP2B", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TFAP2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor AP-2 beta", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8866904); (R-SSC-8866907); (R-SSC-9834899)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein 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"refseq_ac": "XP_003353805", "gene_names_uniprotkb": "BBS1", "gene_names_refseq": "BBS1", "protein_names_uniprotkb": "Bardet-Biedl syndrome 1", "protein_names_refseq": "Bardet-Biedl syndrome 1 protein isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100627390); (R-SSC-5620922)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051219 phosphoprotein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0005113 patched binding;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005813 centrosome;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0034451 centriolar satellite;GO:0060170 ciliary membrane", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0045444 fat cell differentiation;GO:1905515 non-motile cilium assembly;GO:0061512 protein localization to cilium;GO:0060296 regulation of cilium beat frequency involved in ciliary motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZWI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZWR5-1", "uniprot_id": "A0A286ZWR5_PIG", "mass": 53040.0, "length": 461, "protein_name": "Phosphatidate cytidylyltransferase", "gene_name": "CDS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase; 2.7.7.41", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1483226)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, 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"refseq_ac": "", "gene_names_uniprotkb": "CELSR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042130 negative regulation of T cell proliferation;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZX54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ANR6-1", "uniprot_id": "A0A287ANR6_PIG", "mass": 108353.0, "length": 967, "protein_name": "Mitogen-activated protein kinase kinase kinase 13", "gene_name": "MAP3K13", "organism": "Pig", "refseq_name": "mitogen-activated protein kinase kinase kinase 13", "refseq_ac": "XP_020925639", "gene_names_uniprotkb": "MAP3K13", "gene_names_refseq": "MAP3K13", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 13; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 13", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515448)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:1905492 positive regulation of branching morphogenesis of a nerve;GO:0007165 signal transduction;GO:0007254 JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ANR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B3I8-1", "uniprot_id": "A0A287B3I8_PIG", "mass": 60428.0, "length": 562, "protein_name": "Retinoic acid receptor RXR", "gene_name": "RXRA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RXRA", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR; Nuclear receptor subfamily 2 group B member", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-159418); (R-SSC-192105); (R-SSC-193368); (R-SSC-193807); (R-SSC-200425); (R-SSC-211976); (R-SSC-381340); (R-SSC-383280); (R-SSC-400206); (R-SSC-4090294); (R-SSC-5362517); (R-SSC-9029569); (R-SSC-9616222); (R-SSC-9623433); (R-SSC-9841922)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0043565 sequence-specific DNA binding;GO:0050693 LBD domain binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B3I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZXS3-1", "uniprot_id": "A0A286ZXS3_PIG", "mass": 34172.0, "length": 331, "protein_name": "TAL bHLH transcription factor 1, erythroid differentiation factor", "gene_name": "TAL1", "organism": "Pig", "refseq_name": "T-cell acute lymphocytic leukemia protein 1 isoform X1", "refseq_ac": "XP_005656227", "gene_names_uniprotkb": "TAL1", "gene_names_refseq": "TAL1", "protein_names_uniprotkb": "TAL bHLH transcription factor 1, erythroid differentiation factor", "protein_names_refseq": "T-cell acute lymphocytic leukemia protein 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521731); (R-SSC-8939236)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0035162 embryonic hemopoiesis;GO:0030221 basophil differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZXS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZY67-1", "uniprot_id": "A0A286ZY67_PIG", "mass": 147323.0, "length": 1323, "protein_name": "Lysine-specific demethylase", "gene_name": "KDM3A", "organism": "Pig", "refseq_name": "lysine-specific demethylase 3A isoform X1", "refseq_ac": "XP_003124983", "gene_names_uniprotkb": "KDM3A", "gene_names_refseq": "KDM3A", "protein_names_uniprotkb": "Lysine-specific demethylase; 1.14.11.65", "protein_names_refseq": "lysine-specific demethylase 3A isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517522); (R-SSC-3214842)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0050681 nuclear androgen receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0046293 formaldehyde biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030521 androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZY67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZYA9-1", "uniprot_id": "A0A286ZYA9_PIG", "mass": 43677.0, "length": 388, "protein_name": "P2X purinoceptor", "gene_name": "P2RX4", "organism": "Pig", "refseq_name": "P2X purinoceptor 4", "refseq_ac": "XP_020928697", "gene_names_uniprotkb": "P2RX4", "gene_names_refseq": "P2RX4", "protein_names_uniprotkb": "P2X purinoceptor; P2X purinoceptor 4", "protein_names_refseq": "P2X purinoceptor 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157723); (R-SSC-139853); (R-SSC-418346)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Could also function as an ATP-gated cation channel of lysosomal membranes., [UniProtKB, UniProtKB]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0098794 postsynapse", "go_biological_process": "GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0008217 regulation of blood pressure;GO:0051899 membrane depolarization;GO:0097190 apoptotic signaling pathway;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZYA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A3A4-1", "uniprot_id": "A0A287A3A4_PIG", "mass": 169559.0, "length": 1523, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase", "gene_name": "PPIP5K1", "organism": "Pig", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5", "refseq_ac": "XP_020952379", "gene_names_uniprotkb": "PPIP5K1", "gene_names_refseq": "PPIP5K1", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; 2.7.4.24", "protein_names_refseq": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1855167)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity;GO:0005524 ATP binding;GO:0052723 inositol hexakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A3A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZYJ8-1", "uniprot_id": "A0A286ZYJ8_PIG", "mass": 124316.0, "length": 1127, "protein_name": "Regulator of nonsense transcripts 1", "gene_name": "UPF1", "organism": "Pig", "refseq_name": "regulator of nonsense transcripts 1 isoform X3", "refseq_ac": "XP_020939129", "gene_names_uniprotkb": "UPF1", "gene_names_refseq": "UPF1", "protein_names_uniprotkb": "Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog", "protein_names_refseq": "regulator of nonsense transcripts 1 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-975956); (R-SSC-975957)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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granule;GO:0000785 chromatin", "go_biological_process": "GO:0032201 telomere maintenance via semi-conservative replication;GO:0006449 regulation of translational termination;GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A286ZYJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286ZZG5-1", "uniprot_id": "A0A286ZZG5_PIG", "mass": 66660.0, "length": 601, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "organism": "Pig", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1", "refseq_ac": "XP_020947620", "gene_names_uniprotkb": "DYRK2", "gene_names_refseq": "DYRK2", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 2; 2.7.12.1", "protein_names_refseq": "dual specificity 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3.5.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9845614)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010506 regulation of autophagy;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A359-1", "uniprot_id": "A0A287A359_PIG", "mass": 25103.0, "length": 223, "protein_name": "Cyanocobalamin reductase / alkylcobalamin dealkylase", "gene_name": "MMACHC", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MMACHC", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyanocobalamin reductase / alkylcobalamin dealkylase; 1.16.1.6; 2.5.1.151; Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); Methylmalonic aciduria and homocystinuria type C protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9759218)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043295 glutathione binding;GO:0042803 protein homodimerization activity;GO:0071949 FAD binding;GO:0032451 demethylase activity;GO:0031419 cobalamin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0070988 demethylation;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480T797-1", "uniprot_id": "A0A480T797_PIG", "mass": 148462.0, "length": 1344, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 3", "gene_name": "MAPK8IP3", "organism": "Pig", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 3 isoform X12", "refseq_ac": "XP_013843212", "gene_names_uniprotkb": "MAPK8IP3", "gene_names_refseq": "MAPK8IP3", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 3; 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Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0010756 positive regulation of plasminogen activation;GO:0030194 positive regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AX98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A3C8-1", "uniprot_id": "A0A287A3C8_PIG", "mass": 199711.0, "length": 1749, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "UBR2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UBR2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-983168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0070728 L-leucine binding;GO:0141053 histone H2A ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex;GO:0005694 chromosome", "go_biological_process": "GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0016567 protein ubiquitination;GO:0032007 negative regulation of TOR signaling;GO:0007140 male meiotic nuclear division;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A3C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A3D8-1", "uniprot_id": "A0A287A3D8_PIG", "mass": 40747.0, "length": 393, "protein_name": "CD34 molecule", "gene_name": "CD34", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CD34", "gene_names_refseq": "", "protein_names_uniprotkb": "CD34 molecule", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0043199 sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0045171 intercellular bridge;GO:0005886 plasma membrane", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007165 signal transduction;GO:0001894 tissue homeostasis;GO:0045766 positive regulation of angiogenesis;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A3D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A3L1-1", "uniprot_id": "A0A287A3L1_PIG", "mass": 18190.0, "length": 161, "protein_name": "Phospholipase A2", "gene_name": "PLA2G2D", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PLA2G2D", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1482788); (R-SSC-1482801); (R-SSC-1482839); (R-SSC-1482922); (R-SSC-1482925); (R-SSC-1483166)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0042130 negative regulation of T cell proliferation;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A3L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A496-1", "uniprot_id": "A0A287A496_PIG", "mass": 43920.0, "length": 394, "protein_name": "RNA demethylase ALKBH5", "gene_name": "ALKBH5", "organism": "Pig", "refseq_name": "RNA demethylase ALKBH5", "refseq_ac": "XP_020923654", "gene_names_uniprotkb": "ALKBH5", "gene_names_refseq": "ALKBH5", "protein_names_uniprotkb": "RNA demethylase ALKBH5; 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "protein_names_refseq": "RNA demethylase ALKBH5", "tax_id": 9823, "disease": "", "pathway": " (ssc:100622998); (R-SSC-73943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0042382 paraspeckles", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0001666 response to hypoxia;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A496-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AD26-1", "uniprot_id": "A0A287AD26_PIG", "mass": 124632.0, "length": 1123, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "RC3H1", "organism": "Pig", "refseq_name": "roquin-1 isoform X3", "refseq_ac": "XP_005656778", "gene_names_uniprotkb": "RC3H1", "gene_names_refseq": "RC3H1", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 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2.4.3.2; 2.4.3.4; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; ST3Gal II; ST3GalA.2; Sialyltransferase 4B", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100627772); (R-SSC-2022854); (R-SSC-4085001); (R-SSC-977068); (R-SSC-9840309)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0097503 sialylation;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 412, "hit_score": 0.2, "record_id": "A0A287A537-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1U981-1", "uniprot_id": "A0A4X1U981_PIG", "mass": 29954.0, "length": 268, "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "organism": "Pig", "refseq_name": "zinc finger protein SNAI2", "refseq_ac": "NP_001121911", "gene_names_uniprotkb": "SNAI2", "gene_names_refseq": "SNAI2", "protein_names_uniprotkb": "Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2", "protein_names_refseq": "slug; snail homolog 2; zinc finger protein SNAI2; zinc-finger transcription factor SLUG", "tax_id": 9823, "disease": "", "pathway": " (ssc:102162332)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A115", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:0007219 Notch signaling pathway;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1U981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BBR6-1", "uniprot_id": "A0A287BBR6_PIG", "mass": 149321.0, "length": 1325, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "ABCC4", "organism": "Pig", "refseq_name": "multidrug resistance-associated protein 4 isoform X1", "refseq_ac": "XP_020921445", "gene_names_uniprotkb": "ABCC4", "gene_names_refseq": "ABCC4", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; Multidrug resistance-associated protein 4; cAMP-dependent chloride channel", "protein_names_refseq": "multidrug resistance-associated protein 4 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152536); (R-SSC-114608); (R-SSC-382556); (R-SSC-9748787); (R-SSC-9753281)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BBR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A6X5-1", "uniprot_id": "A0A287A6X5_PIG", "mass": 47364.0, "length": 444, "protein_name": "Serine protease HTRA2, mitochondrial", "gene_name": "HTRA2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HTRA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9837999)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0071300 cellular response to retinoic acid;GO:0034605 cellular response to heat;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A6X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A7C6-1", "uniprot_id": "A0A287A7C6_PIG", "mass": 47996.0, "length": 423, "protein_name": "Bone morphogenetic protein 10", "gene_name": "BMP10", "organism": "Pig", "refseq_name": "bone morphogenetic protein 10", "refseq_ac": "XP_003125118", "gene_names_uniprotkb": "BMP10", "gene_names_refseq": "BMP10", "protein_names_uniprotkb": "Bone morphogenetic protein 10", "protein_names_refseq": "bone morphogenetic protein 10", "tax_id": 9823, "disease": "", "pathway": " (ssc:100514573); (R-SSC-201451); (R-SSC-2129379)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1W9X6", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031433 telethonin binding;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030018 Z disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0030509 BMP signaling pathway;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A7C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A8A9-1", "uniprot_id": "A0A287A8A9_PIG", "mass": 24022.0, "length": 221, "protein_name": "Toll/interleukin-1 receptor domain-containing adapter protein", "gene_name": "TIRAP", "organism": "Pig", "refseq_name": "toll/interleukin-1 receptor domain-containing adapter protein", "refseq_ac": "XP_003130108", "gene_names_uniprotkb": "TIRAP", "gene_names_refseq": "TIRAP", "protein_names_uniprotkb": "Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein", "protein_names_refseq": "toll/interleukin-1 receptor domain-containing adapter protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:100514174); (R-SSC-166058)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0035591 signaling adaptor activity;GO:0035662 Toll-like receptor 4 binding;GO:0035663 Toll-like receptor 2 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A8A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287A8I5-1", "uniprot_id": "A0A287A8I5_PIG", "mass": 112681.0, "length": 983, "protein_name": "Myosin IG", "gene_name": "MYO1G", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYO1G", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin IG", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287A8I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ATS3-1", "uniprot_id": "A0A287ATS3_PIG", "mass": 138715.0, "length": 1236, "protein_name": "Serine/threonine-protein kinase TAO2", "gene_name": "TAOK2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TAOK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO2; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8D2BTC1", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0038191 neuropilin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0043235 receptor complex", "go_biological_process": "GO:0007409 axonogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ATS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AA21-1", "uniprot_id": "A0A287AA21_PIG", "mass": 34580.0, "length": 328, "protein_name": "Enoyl-CoA hydratase, mitochondrial", "gene_name": "ECHS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ECHS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Enoyl-CoA hydratase, mitochondrial; 4.2.1.17; 5.3.3.8; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-70895); (R-SSC-77310); (R-SSC-77346); (R-SSC-77348); (R-SSC-77350); (R-SSC-77352)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480SDD9", "ec_number_list": "", "go_molecular_function": "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0043956 3-hydroxypropionyl-CoA dehydratase activity;GO:0004300 enoyl-CoA hydratase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006574 L-valine catabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AA21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AAP7-1", "uniprot_id": "A0A287AAP7_PIG", "mass": 55144.0, "length": 495, "protein_name": "Activin receptor type-1C", "gene_name": "ACVR1C", "organism": "Pig", "refseq_name": "activin receptor type-1C isoform X2", "refseq_ac": "XP_003133466", "gene_names_uniprotkb": "ACVR1C", "gene_names_refseq": "ACVR1C", "protein_names_uniprotkb": "Activin receptor type-1C; 2.7.11.30; Activin receptor type IC; Activin receptor-like kinase 7", "protein_names_refseq": "activin receptor type-1C isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100156756); (R-SSC-1502540)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0016361 activin receptor activity, type I;GO:0038100 nodal binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0097190 apoptotic signaling pathway;GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AAP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AAT1-1", "uniprot_id": "A0A287AAT1_PIG", "mass": 238997.0, "length": 2093, "protein_name": "Citron Rho-interacting kinase", "gene_name": "CIT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CIT", "gene_names_refseq": "", "protein_names_uniprotkb": "Citron Rho-interacting kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5625900); (R-SSC-8980692); (R-SSC-9013026); (R-SSC-9013106); (R-SSC-9013149)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in cytokinesis. Displays serine/threonine protein kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051402 neuron apoptotic process;GO:0000281 mitotic cytokinesis;GO:0035331 negative regulation of hippo signaling;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AAT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AB45-1", "uniprot_id": "A0A287AB45_PIG", "mass": 90818.0, "length": 835, "protein_name": "ATP-dependent 6-phosphofructokinase", "gene_name": "PFKP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PFKP", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase; 2.7.1.11; ATP-PFK; Phosphofructokinase; Phosphohexokinase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-70171)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AB45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ABN3-1", "uniprot_id": "A0A287ABN3_PIG", "mass": 31165.0, "length": 276, "protein_name": "Phospholipid phosphatase 3", "gene_name": "PLPP3", "organism": "Pig", "refseq_name": "phospholipid phosphatase 3 isoform X2", "refseq_ac": "XP_005665445", "gene_names_uniprotkb": "PLPP3", "gene_names_refseq": "PLPP3", "protein_names_uniprotkb": "Phospholipid phosphatase 3; 3.1.3.4; Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b", "protein_names_refseq": "phospholipid phosphatase 3 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9845614)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0070097 delta-catenin binding;GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane;GO:0045121 membrane raft;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010595 positive regulation of endothelial cell migration;GO:0033631 cell-cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ABN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ABR0-1", "uniprot_id": "A0A287ABR0_PIG", "mass": 132190.0, "length": 1184, "protein_name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "gene_name": "INPP5D", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "INPP5D", "gene_names_refseq": "", "protein_names_uniprotkb": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; 3.1.3.86", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1660499); (R-SSC-1855204); (R-SSC-202424); (R-SSC-210990); (R-SSC-912526)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0050776 regulation of immune response;GO:0009968 negative regulation of signal transduction;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0045579 positive regulation of B cell differentiation;GO:0045779 negative regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ABR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AC03-1", "uniprot_id": "A0A287AC03_PIG", "mass": 135095.0, "length": 1198, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2", "gene_name": "PAN2", "organism": "Pig", "refseq_name": "PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X7", "refseq_ac": "XP_001929328", "gene_names_uniprotkb": "PAN2", "gene_names_refseq": "PAN2", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "PAB-dependent poly(A)-specific ribonuclease subunit PAN2 isoform X7", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153107); (R-SSC-429947)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BMV3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AC03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B3R7-1", "uniprot_id": "A0A287B3R7_PIG", "mass": 37795.0, "length": 339, "protein_name": "Acyltransferase", "gene_name": "DGAT2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DGAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyltransferase; 2.3.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006071 glycerol metabolic process;GO:0046339 diacylglycerol metabolic process;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B3R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480QJ99-1", "uniprot_id": "A0A480QJ99_PIG", "mass": 73517.0, "length": 650, "protein_name": "Epithelial sodium channel subunit alpha", "gene_name": "SCNN1A", "organism": "Pig", "refseq_name": "amiloride-sensitive sodium channel subunit alpha isoform X1", "refseq_ac": "XP_020946765", "gene_names_uniprotkb": "SCNN1A", "gene_names_refseq": "SCNN1A", "protein_names_uniprotkb": "Epithelial sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha", "protein_names_refseq": "amiloride-sensitive sodium channel subunit alpha isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2672351); (R-SSC-9730628)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0031514 motile cilium;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle;GO:0034706 sodium channel complex;GO:0005829 cytosol", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0098719 sodium ion import across plasma membrane;GO:0035725 sodium ion transmembrane transport;GO:0050891 multicellular organismal-level water homeostasis;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A480QJ99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AG73-1", "uniprot_id": "A0A287AG73_PIG", "mass": 155724.0, "length": 1384, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "LOC100518860", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC100518860", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; Multidrug resistance-associated protein 4; cAMP-dependent chloride channel", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0005260 intracellularly ATP-gated chloride channel activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AG73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ACN5-1", "uniprot_id": "A0A287ACN5_PIG", "mass": 24012.0, "length": 218, "protein_name": "Heart- and neural crest derivatives-expressed protein 1", "gene_name": "HAND1", "organism": "Pig", "refseq_name": "heart- and neural crest derivatives-expressed protein 1 isoform X1", "refseq_ac": "XP_005672651", "gene_names_uniprotkb": "HAND1", "gene_names_refseq": "HAND1", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1", "protein_names_refseq": "heart- and neural crest derivatives-expressed protein 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0001829 trophectodermal cell differentiation;GO:0003218 cardiac left ventricle formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ACN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ACR8-1", "uniprot_id": "A0A287ACR8_PIG", "mass": 19311.0, "length": 168, "protein_name": "N-alpha-acetyltransferase 50", "gene_name": "NAA50", "organism": "Pig", "refseq_name": "N-alpha-acetyltransferase 50 isoform X1", "refseq_ac": "XP_005670258", "gene_names_uniprotkb": "NAA50", "gene_names_refseq": "NAA50", "protein_names_uniprotkb": "N-alpha-acetyltransferase 50; 2.3.1.258; N-epsilon-acetyltransferase 50; NatE catalytic subunit", "protein_names_refseq": "N-alpha-acetyltransferase 50 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031415 NatA complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ACR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AD23-1", "uniprot_id": "A0A287AD23_PIG", "mass": 34646.0, "length": 323, "protein_name": "Homeobox protein Nkx-2.5", "gene_name": "NKX2-5", "organism": "Pig", "refseq_name": "homeobox protein Nkx-2.5", "refseq_ac": "XP_003134089", "gene_names_uniprotkb": "NKX2-5", "gene_names_refseq": "NKX2-5", "protein_names_uniprotkb": "Homeobox protein Nkx-2.5; Homeobox protein NK-2 homolog E", "protein_names_refseq": "homeobox protein Nkx-2.5", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521411)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0003285 septum secundum development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AD23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ADH9-1", "uniprot_id": "A0A287ADH9_PIG", "mass": 28727.0, "length": 253, "protein_name": "Chloride intracellular channel protein", "gene_name": "CLIC4", "organism": "Pig", "refseq_name": "chloride intracellular channel protein 4", "refseq_ac": "XP_020951248", "gene_names_uniprotkb": "CLIC4", "gene_names_refseq": "CLIC4", "protein_names_uniprotkb": "Chloride intracellular channel protein", "protein_names_refseq": "chloride intracellular channel protein 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100622787)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0030216 keratinocyte differentiation;GO:0071277 cellular response to calcium ion;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ADH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ADJ2-1", "uniprot_id": "A0A287ADJ2_PIG", "mass": 73650.0, "length": 679, "protein_name": "Stress-70 protein, mitochondrial", "gene_name": "HSPA9", "organism": "Pig", "refseq_name": "stress-70 protein, mitochondrial", "refseq_ac": "XP_005661752", "gene_names_uniprotkb": "HSPA9", "gene_names_refseq": "HSPA9", "protein_names_uniprotkb": "Stress-70 protein, mitochondrial; 3.6.4.10; 75 kDa glucose-regulated protein; Heat shock 70 kDa protein 9", "protein_names_refseq": "stress-70 protein, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521183); (R-SSC-3371453); (R-SSC-6799198); (R-SSC-9837999); (R-SSC-9865881)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8D0HQ94", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation;GO:0042026 protein refolding;GO:0045647 negative regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ADJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AEF3-1", "uniprot_id": "A0A287AEF3_PIG", "mass": 18400.0, "length": 168, "protein_name": "BCL2 associated agonist of cell death", "gene_name": "BAD", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BAD", "gene_names_refseq": "", "protein_names_uniprotkb": "BCL2 associated agonist of cell death", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-111447); (R-SSC-111453); (R-SSC-193648)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140608 cysteine-type endopeptidase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0097138 BAD-BCL-2 complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0097191 extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AEF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AF07-1", "uniprot_id": "A0A287AF07_PIG", "mass": 33420.0, "length": 308, "protein_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "gene_name": "SIRT5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SIRT5", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-5, mitochondrial; 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2151201); (R-SSC-70635)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036054 protein-malonyllysine demalonylase activity;GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0008270 zinc ion binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010566 regulation of ketone biosynthetic process;GO:2000378 negative regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AF07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BDI5-1", "uniprot_id": "A0A287BDI5_PIG", "mass": 60819.0, "length": 553, "protein_name": "Nuclear factor 1", "gene_name": "NFIA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NFIA", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100523676)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BDI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AG36-1", "uniprot_id": "A0A287AG36_PIG", "mass": 332264.0, "length": 3041, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "LAMA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LAMA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein; Laminin A chain; Perlecan", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6., [UniProtKB, UniProtKB]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB]; Has anti-angiogenic properties that require binding of calcium ions for full activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0046872 metal ion binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0005604 basement membrane", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AG36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AG39-1", "uniprot_id": "A0A287AG39_PIG", "mass": 23670.0, "length": 231, "protein_name": "Small nuclear ribonucleoprotein-associated protein", "gene_name": "SNRPB", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SNRPB", "gene_names_refseq": "", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-111367); (R-SSC-191859); (R-SSC-72163); (R-SSC-72165); (R-SSC-73856); (R-SSC-77588); (R-SSC-9770562); (R-SSC-9943411)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0005687 U4 snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AG39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AGC8-1", "uniprot_id": "A0A287AGC8_PIG", "mass": 79841.0, "length": 728, "protein_name": "Ski oncogene", "gene_name": "SKI", "organism": "Pig", "refseq_name": "ski oncogene", "refseq_ac": "XP_020950860", "gene_names_uniprotkb": "SKI", "gene_names_refseq": "SKI", "protein_names_uniprotkb": "Ski oncogene; Proto-oncogene c-Ski", "protein_names_refseq": "ski oncogene", "tax_id": 9823, "disease": "", "pathway": " (ssc:110261080); (R-SSC-201451); (R-SSC-2173795)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005667 transcription regulator complex;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030514 negative regulation of BMP signaling pathway;GO:0032926 negative regulation of activin receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AGC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AGF6-1", "uniprot_id": "A0A287AGF6_PIG", "mass": 122356.0, "length": 1083, "protein_name": "Anion exchange protein", "gene_name": "SLC4A10", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC4A10", "gene_names_refseq": "", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-425381)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015293 symporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0055085 transmembrane transport;GO:0007601 visual perception;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AGF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AGV9-1", "uniprot_id": "A0A287AGV9_PIG", "mass": 68547.0, "length": 597, "protein_name": "mRNA-capping enzyme", "gene_name": "RNGTT", "organism": "Pig", "refseq_name": "mRNA-capping enzyme", "refseq_ac": "XP_020945587", "gene_names_uniprotkb": "RNGTT", "gene_names_refseq": "RNGTT", "protein_names_uniprotkb": "mRNA-capping enzyme; GTP--RNA guanylyltransferase; GTase; mRNA 5'-phosphatase", "protein_names_refseq": "mRNA-capping enzyme", "tax_id": 9823, "disease": "", "pathway": " (ssc:100520874); (R-SSC-72086); (R-SSC-77075)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004651 polynucleotide 5'-phosphatase activity;GO:0004484 mRNA guanylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AGV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AIL5-1", "uniprot_id": "A0A287AIL5_PIG", "mass": 91896.0, "length": 830, "protein_name": "Phosphodiesterase", "gene_name": "PDE4A", "organism": "Pig", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 2", "refseq_ac": "NP_001422223", "gene_names_uniprotkb": "PDE4A", "gene_names_refseq": "PDE4A", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 2; cyclic AMP-specific phosphodiesterase SSPDE4A1A; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-180024); (R-SSC-418555)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A480TIJ4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AIL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AIP7-1", "uniprot_id": "A0A287AIP7_PIG", "mass": 85680.0, "length": 771, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "ACSL1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ACSL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase; Long-chain acyl-CoA synthetase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2046105); (R-SSC-2046106); (R-SSC-75876)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0047676 arachidonate-CoA ligase activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0090433 palmitoyl-CoA ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AIP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AIX4-1", "uniprot_id": "A0A287AIX4_PIG", "mass": 31436.0, "length": 289, "protein_name": "Distal-less homeobox 5", "gene_name": "DLX5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DLX5", "gene_names_refseq": "", "protein_names_uniprotkb": "Distal-less homeobox 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0030509 BMP signaling pathway;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AIX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AJ51-1", "uniprot_id": "A0A287AJ51_PIG", "mass": 51395.0, "length": 478, "protein_name": "Angiotensinogen", "gene_name": "AGT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AGT", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensinogen; Serpin A8", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2022377); (R-SSC-375276); (R-SSC-416476); (R-SSC-418594)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor., [UniProtKB, UniProtKB, UniProtKB]; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [UniProtKB, UniProtKB, UniProtKB]; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB, UniProtKB]; Stimulates aldosterone release., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031702 type 1 angiotensin receptor binding;GO:0031703 type 2 angiotensin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001822 kidney development;GO:0010595 positive regulation of endothelial cell migration;GO:0001819 positive regulation of cytokine production;GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AJ51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AJ91-1", "uniprot_id": "A0A287AJ91_PIG", "mass": 57373.0, "length": 535, "protein_name": "DnaJ heat shock protein family (Hsp40) member A3", "gene_name": "DNAJA3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DNAJA3", "gene_names_refseq": "", "protein_names_uniprotkb": "DnaJ heat shock protein family (Hsp40) member A3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005884 actin filament;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007528 neuromuscular junction development;GO:0008285 negative regulation of cell population proliferation;GO:0006457 protein folding;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AJ91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AJ97-1", "uniprot_id": "A0A287AJ97_PIG", "mass": 43186.0, "length": 368, "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FNTA", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; 2.5.1.58; 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0004663 Rab geranylgeranyltransferase activity;GO:0008017 microtubule binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex;GO:0005965 protein farnesyltransferase complex;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0035022 positive regulation of Rac protein signal transduction;GO:0007167 enzyme-linked receptor protein signaling pathway;GO:0071340 skeletal muscle acetylcholine-gated channel clustering;GO:0060632 regulation of microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AJ97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AJQ6-1", "uniprot_id": "A0A287AJQ6_PIG", "mass": 76018.0, "length": 709, "protein_name": "Dishevelled segment polarity protein 2", "gene_name": "DVL2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DVL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dishevelled segment polarity protein 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-201688); (R-SSC-2028269); (R-SSC-4086400); (R-SSC-4608870); (R-SSC-4641258); (R-SSC-4641262); (R-SSC-5099900); (R-SSC-5663220); (R-SSC-8856825); (R-SSC-8856828)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0045177 apical part of cell;GO:0030136 clathrin-coated vesicle;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade;GO:0035282 segmentation;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AJQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BNG5-1", "uniprot_id": "A0A287BNG5_PIG", "mass": 158077.0, "length": 1358, "protein_name": "RAD50 double strand break repair protein", "gene_name": "RAD50", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAD50", "gene_names_refseq": "", "protein_names_uniprotkb": "RAD50 double strand break repair protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2559586); (R-SSC-5685938); (R-SSC-5685939); (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5693548); (R-SSC-5693565); (R-SSC-5693568); (R-SSC-5693571); (R-SSC-5693579); (R-SSC-5693607); (R-SSC-5693616); (R-SSC-6804756); (R-SSC-69473)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0030870 Mre11 complex;GO:0000781 chromosome, telomeric region;GO:0000794 condensed nuclear chromosome;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair;GO:0051321 meiotic cell cycle;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BNG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AL22-1", "uniprot_id": "A0A287AL22_PIG", "mass": 34833.0, "length": 316, "protein_name": "Transcription initiation factor IIB", "gene_name": "GTF2B", "organism": "Pig", "refseq_name": "transcription initiation factor IIB", "refseq_ac": "XP_001929441", "gene_names_uniprotkb": "GTF2B", "gene_names_refseq": "GTF2B", "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB", "protein_names_refseq": "transcription initiation factor IIB", "tax_id": 9823, "disease": "", "pathway": " (ssc:100155974)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z5J6", "ec_number_list": "", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0032993 protein-DNA complex;GO:0005669 transcription factor TFIID complex;GO:0042585 germinal vesicle", "go_biological_process": "GO:0019083 viral transcription;GO:0051225 spindle assembly;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0051177 meiotic sister chromatid cohesion;GO:0001174 transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AL22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1TUL8-1", "uniprot_id": "A0A4X1TUL8_PIG", "mass": 53787.0, "length": 463, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "CALCRL", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CALCRL", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:397172); (R-SSC-419812); (R-SSC-9856530)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A7L3", "ec_number_list": "", "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:1903143 adrenomedullin receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0001525 angiogenesis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0015031 protein transport;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1TUL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ALJ7-1", "uniprot_id": "A0A287ALJ7_PIG", "mass": 22657.0, "length": 221, "protein_name": "Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1", "gene_name": "CITED1", "organism": "Pig", "refseq_name": "cbp/p300-interacting transactivator 1 isoform X3", "refseq_ac": "XP_013846376", "gene_names_uniprotkb": "CITED1", "gene_names_refseq": "CITED1", "protein_names_uniprotkb": "Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1", "protein_names_refseq": "cbp/p300-interacting transactivator 1 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8866907); (R-SSC-9018519)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050693 LBD domain binding;GO:0070410 co-SMAD binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070669 response to interleukin-2;GO:0071104 response to interleukin-9;GO:0071105 response to interleukin-11;GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ALJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ALN0-1", "uniprot_id": "A0A287ALN0_PIG", "mass": 47070.0, "length": 428, "protein_name": "Flotillin", "gene_name": "FLOT2", "organism": "Pig", "refseq_name": "flotillin-2 isoform X2", "refseq_ac": "XP_020923156", "gene_names_uniprotkb": "FLOT2", "gene_names_refseq": "FLOT2", "protein_names_uniprotkb": "Flotillin", "protein_names_refseq": "flotillin-2 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100518752); (R-SSC-5213460); (R-SSC-5675482); (R-SSC-8849932); (R-SSC-8980692); (R-SSC-9013026); (R-SSC-9013106); (R-SSC-9696264); (R-SSC-9696273)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:1903905 positive regulation of establishment of T cell polarity;GO:0010629 negative regulation of gene expression;GO:0072659 protein localization to plasma membrane;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ALN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480ZTJ9-1", "uniprot_id": "A0A480ZTJ9_PIG", "mass": 80707.0, "length": 722, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "ACSL6", "organism": "Pig", "refseq_name": "long-chain-fatty-acid--CoA ligase 6 isoform X2", "refseq_ac": "XP_005661690", "gene_names_uniprotkb": "ACSL6", "gene_names_refseq": "ACSL6", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase; Long-chain acyl-CoA synthetase", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase 6 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522126); (R-SSC-75876)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0047676 arachidonate-CoA ligase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A480ZTJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ALS4-1", "uniprot_id": "A0A287ALS4_PIG", "mass": 84654.0, "length": 787, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "SIK1", "organism": "Pig", "refseq_name": "serine/threonine-protein kinase SIK1", "refseq_ac": "XP_020926717", "gene_names_uniprotkb": "SIK1", "gene_names_refseq": "SIK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase SIK1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100621265)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0035556 intracellular signal transduction;GO:0007346 regulation of mitotic cell cycle;GO:0055007 cardiac muscle cell differentiation;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ALS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480S426-1", "uniprot_id": "A0A480S426_PIG", "mass": 63267.0, "length": 560, "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "IFNAR1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IFNAR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-909733); (R-SSC-912694)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2R7X2", "ec_number_list": "", "go_molecular_function": "GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding;GO:0008269 JAK pathway signal transduction adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0009893 positive regulation of metabolic process;GO:0032496 response to lipopolysaccharide;GO:0009615 response to virus;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A480S426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AM98-1", "uniprot_id": "A0A287AM98_PIG", "mass": 38166.0, "length": 340, "protein_name": "Acyltransferase", "gene_name": "LOC110259135", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC110259135", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyltransferase; 2.3.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1482883); (R-SSC-75109)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AM98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AMD1-1", "uniprot_id": "A0A287AMD1_PIG", "mass": 119686.0, "length": 1049, "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "TOPORS", "organism": "Pig", "refseq_name": "E3 ubiquitin-protein ligase Topors isoform X1", "refseq_ac": "XP_005668133", "gene_names_uniprotkb": "TOPORS", "gene_names_refseq": "TOPORS", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Topors; 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2-hydroxy-dATP diphosphatase; 3.6.1.56; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; Methylated purine nucleoside triphosphate hydrolase; Nucleoside diphosphate-linked moiety X motif 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2393930)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0008828 dATP diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042262 DNA protection", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AR30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ARB7-1", "uniprot_id": "A0A287ARB7_PIG", "mass": 40381.0, "length": 355, "protein_name": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "gene_name": "ST8SIA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ST8SIA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; 2.4.3.8; Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Sialyltransferase 8A; Sialyltransferase St8Sia I", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QF15", "ec_number_list": "", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.2, "record_id": "A0A287ARB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ARE6-1", "uniprot_id": "A0A287ARE6_PIG", "mass": 124291.0, "length": 1068, "protein_name": "GRB10 interacting GYF protein 2", "gene_name": "GIGYF2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GIGYF2", "gene_names_refseq": "", "protein_names_uniprotkb": "GRB10 interacting GYF protein 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0060090 molecular adaptor activity;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0045947 negative regulation of translational initiation;GO:0048009 insulin-like growth factor receptor signaling pathway;GO:0061157 mRNA destabilization;GO:0060339 negative regulation of type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ARE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ARI1-1", "uniprot_id": "A0A287ARI1_PIG", "mass": 36322.0, "length": 348, "protein_name": "Eukaryotic translation initiation factor 3 subunit F", "gene_name": "EIF3F", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EIF3F; EIF3S5", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47; eIF3f", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-156827); (R-SSC-72649); (R-SSC-72689); (R-SSC-72695); (R-SSC-72702)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP]; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003743 translation initiation factor activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0031369 translation initiation factor binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ARI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BEZ7-1", "uniprot_id": "A0A287BEZ7_PIG", "mass": 68006.0, "length": 609, "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "SGPL1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SGPL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingosine-1-phosphate lyase 1; 4.1.2.27; Sphingosine-1-phosphate aldolase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9845614)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008117 sphinganine-1-phosphate aldolase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0019752 carboxylic acid metabolic process;GO:0030149 sphingolipid catabolic process;GO:0006631 fatty acid metabolic process;GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BEZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AZA4-1", "uniprot_id": "A0A287AZA4_PIG", "mass": 97059.0, "length": 886, "protein_name": "Cytosolic carboxypeptidase-like protein 5", "gene_name": "AGBL5", "organism": "Pig", "refseq_name": "cytosolic carboxypeptidase-like protein 5 isoform X1", "refseq_ac": "XP_020943372", "gene_names_uniprotkb": "AGBL5", "gene_names_refseq": "AGBL5", "protein_names_uniprotkb": "Cytosolic carboxypeptidase-like protein 5; 3.4.17.24; ATP/GTP-binding protein-like 5; Protein deglutamylase CCP5", "protein_names_refseq": "cytosolic carboxypeptidase-like protein 5 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005829 cytosol;GO:0030496 midbody;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AZA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ASS7-1", "uniprot_id": "A0A287ASS7_PIG", "mass": 50101.0, "length": 470, "protein_name": "Transcription factor SOX-10", "gene_name": "SOX10", "organism": "Pig", "refseq_name": "transcription factor SOX-10 isoform X1", "refseq_ac": "XP_013852967", "gene_names_uniprotkb": "SOX10", "gene_names_refseq": "SOX10", "protein_names_uniprotkb": "Transcription factor SOX-10", "protein_names_refseq": "transcription factor SOX-10 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9856649)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ASS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AST0-1", "uniprot_id": "A0A287AST0_PIG", "mass": 23377.0, "length": 213, "protein_name": "Bcl-2-related ovarian killer protein", "gene_name": "BOK", "organism": "Pig", "refseq_name": "bcl-2-related ovarian killer protein isoform X2", "refseq_ac": "XP_020931689", "gene_names_uniprotkb": "BOK", "gene_names_refseq": "BOK", "protein_names_uniprotkb": "Bcl-2-related ovarian killer protein", "protein_names_refseq": "bcl-2-related ovarian killer protein isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0015267 channel activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0032588 trans-Golgi network membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0043065 positive regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AST0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AT21-1", "uniprot_id": "A0A287AT21_PIG", "mass": 38180.0, "length": 356, "protein_name": "Sorbitol dehydrogenase", "gene_name": "SORD", "organism": "Pig", "refseq_name": "sorbitol dehydrogenase isoform X1", "refseq_ac": "XP_020918345", "gene_names_uniprotkb": "SORD", "gene_names_refseq": "SORD", "protein_names_uniprotkb": "Sorbitol dehydrogenase; 1.1.1.14; 1.1.1.9; L-iditol 2-dehydrogenase; Polyol dehydrogenase; SDH; XDH; Xylitol dehydrogenase", "protein_names_refseq": "sorbitol dehydrogenase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5652227); (R-SSC-5661270)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity;GO:0046526 D-xylulose reductase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031514 motile cilium;GO:0031966 mitochondrial membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0046370 fructose biosynthetic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate;GO:0006062 sorbitol catabolic process;GO:0051160 xylitol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AT21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287ATV4-1", "uniprot_id": "A0A287ATV4_PIG", "mass": 21379.0, "length": 192, "protein_name": "small monomeric GTPase", "gene_name": "RAC3", "organism": "Pig", "refseq_name": "ras-related C3 botulinum toxin substrate 3 isoform X1", "refseq_ac": "XP_020922061", "gene_names_uniprotkb": "RAC3", "gene_names_refseq": "RAC3", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related C3 botulinum toxin substrate 3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:110255928); (R-SSC-4086400); (R-SSC-9013423)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0048306 calcium-dependent protein binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0033630 positive regulation of cell adhesion mediated by integrin;GO:0016601 Rac protein signal transduction;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287ATV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AU52-1", "uniprot_id": "A0A287AU52_PIG", "mass": 66194.0, "length": 601, "protein_name": "Nephronectin", "gene_name": "NPNT", "organism": "Pig", "refseq_name": "nephronectin isoform X2", "refseq_ac": "XP_020957363", "gene_names_uniprotkb": "NPNT", "gene_names_refseq": "NPNT", "protein_names_uniprotkb": "Nephronectin", "protein_names_refseq": "nephronectin isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0030485 smooth muscle contractile fiber;GO:0005604 basement membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045987 positive regulation of smooth muscle contraction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0033631 cell-cell adhesion mediated by integrin;GO:0045184 establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AU52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AUN9-1", "uniprot_id": "A0A287AUN9_PIG", "mass": 130185.0, "length": 1175, "protein_name": "Transient receptor potential cation channel subfamily M member 4", "gene_name": "TRPM4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRPM4", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3295583)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0005227 calcium-activated cation channel activity;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0034706 sodium channel complex;GO:0016020 membrane", "go_biological_process": "GO:0086048 membrane depolarization during bundle of His cell action potential;GO:0008284 positive regulation of cell population proliferation;GO:0016925 protein sumoylation;GO:0019722 calcium-mediated signaling;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AUN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BIM2-1", "uniprot_id": "A0A287BIM2_PIG", "mass": 46926.0, "length": 416, "protein_name": "CLN8 transmembrane ER and ERGIC protein", "gene_name": "CLN8", "organism": "Pig", "refseq_name": "protein CLN8 isoform X1", "refseq_ac": "XP_013850632", "gene_names_uniprotkb": "CLN8", "gene_names_refseq": "CLN8", "protein_names_uniprotkb": "CLN8 transmembrane ER and ERGIC protein", "protein_names_refseq": "protein CLN8 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100624678)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097001 ceramide binding", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0007399 nervous system development;GO:0008203 cholesterol metabolic process;GO:0055088 lipid homeostasis;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BIM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1U7Q3-1", "uniprot_id": "A0A4X1U7Q3_PIG", "mass": 59350.0, "length": 527, "protein_name": "Tyrosine-protein kinase", "gene_name": "FGR", "organism": "Pig", "refseq_name": "tyrosine-protein kinase Fgr isoform X2", "refseq_ac": "XP_020951305", "gene_names_uniprotkb": "FGR", "gene_names_refseq": "FGR", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Fgr isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2029481); (R-SSC-432142); (R-SSC-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A287B9K1", "ec_number_list": "", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001784 phosphotyrosine residue binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1U7Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AWK4-1", "uniprot_id": "A0A287AWK4_PIG", "mass": 47705.0, "length": 445, "protein_name": "peptidylprolyl isomerase", "gene_name": "FKBP8", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FKBP8", "gene_names_refseq": "", "protein_names_uniprotkb": "peptidylprolyl isomerase; 5.2.1.8", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5689880)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0097718 disordered domain specific binding;GO:0044183 protein folding chaperone;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0005829 cytosol;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AWK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AWP6-1", "uniprot_id": "A0A287AWP6_PIG", "mass": 37910.0, "length": 348, "protein_name": "Ileal sodium/bile acid cotransporter", "gene_name": "SLC10A2", "organism": "Pig", "refseq_name": "ileal sodium/bile acid cotransporter", "refseq_ac": "NP_001231392", "gene_names_uniprotkb": "SLC10A2", "gene_names_refseq": "SCL10A2; SLC10A2", "protein_names_uniprotkb": "Ileal sodium/bile acid cotransporter; Apical sodium-dependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Na(+)-dependent ileal bile acid transporter; Solute carrier family 10 member 2", "protein_names_refseq": "ileal sodium/bile acid cotransporter; solute carrier family 10 (sodium/bile acid cotransporter family), member 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100625109); (R-SSC-159418)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AWP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AWR7-1", "uniprot_id": "A0A287AWR7_PIG", "mass": 40019.0, "length": 355, "protein_name": "Paraoxonase", "gene_name": "PON1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PON1", "gene_names_refseq": "", "protein_names_uniprotkb": "Paraoxonase; 3.1.1.2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2142688); (R-SSC-9754706)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034366 spherical high-density lipoprotein particle;GO:0005576 extracellular region", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0046434 organophosphate catabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0009636 response to toxic substance;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AWR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AXR1-1", "uniprot_id": "A0A287AXR1_PIG", "mass": 77177.0, "length": 703, "protein_name": "BR serine/threonine kinase 1", "gene_name": "BRSK1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BRSK1", "gene_names_refseq": "", "protein_names_uniprotkb": "BR serine/threonine kinase 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0098793 presynapse", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0099504 synaptic vesicle cycle;GO:0007409 axonogenesis;GO:0008306 associative learning;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AXR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AY51-1", "uniprot_id": "A0A287AY51_PIG", "mass": 102129.0, "length": 912, "protein_name": "DNA (cytosine-5)-methyltransferase 3A", "gene_name": "DNMT3A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DNMT3A", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3A; 2.1.1.37; Cysteine methyltransferase DNMT3A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100037301); (R-SSC-212300); (R-SSC-3214858)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0032259 methylation;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0141196 transposable element silencing by piRNA-mediated DNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AY51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AYR1-1", "uniprot_id": "A0A287AYR1_PIG", "mass": 56803.0, "length": 540, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 10", "gene_name": "SLC2A10", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC2A10", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-189200)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Facilitative glucose transporter required for the development of the cardiovascular system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AYR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AZ60-1", "uniprot_id": "A0A287AZ60_PIG", "mass": 130156.0, "length": 1167, "protein_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase", "gene_name": "MTMR3", "organism": "Pig", "refseq_name": "myotubularin-related protein 3 isoform X7", "refseq_ac": "XP_005670858", "gene_names_uniprotkb": "MTMR3", "gene_names_refseq": "MTMR3", "protein_names_uniprotkb": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase", "protein_names_refseq": "myotubularin-related protein 3 isoform X7", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1632852); (R-SSC-1660499)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0046856 phosphatidylinositol dephosphorylation;GO:1904562 phosphatidylinositol 5-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AZ60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287AZU2-1", "uniprot_id": "A0A287AZU2_PIG", "mass": 150679.0, "length": 1329, "protein_name": "Nephrocystin-3", "gene_name": "NPHP3", "organism": "Pig", "refseq_name": "nephrocystin-3 isoform X3", "refseq_ac": "XP_020925119", "gene_names_uniprotkb": "NPHP3", "gene_names_refseq": "NPHP3", "protein_names_uniprotkb": "Nephrocystin-3", "protein_names_refseq": "nephrocystin-3 isoform X3", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment;GO:0097542 ciliary tip", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0060993 kidney morphogenesis;GO:0048496 maintenance of animal organ identity;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287AZU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B0A0-1", "uniprot_id": "A0A287B0A0_PIG", "mass": 59412.0, "length": 522, "protein_name": "Carotenoid-cleaving dioxygenase, mitochondrial", "gene_name": "BCO2", "organism": "Pig", "refseq_name": "beta,beta-carotene 9',10'-oxygenase isoform X3", "refseq_ac": "XP_005667391", "gene_names_uniprotkb": "BCO2", "gene_names_refseq": "BCO2", "protein_names_uniprotkb": "Carotenoid-cleaving dioxygenase, mitochondrial; 1.13.11.71", "protein_names_refseq": "beta,beta-carotene 9',10'-oxygenase isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-975634)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. 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3.1.3.48; Protein-tyrosine phosphatase receptor type J", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042802 identical protein binding;GO:0051019 mitogen-activated protein kinase binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0032587 ruffle membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B2T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A288CG37-1", "uniprot_id": "A0A288CG37_PIG", "mass": 53736.0, "length": 484, "protein_name": "Hepatocyte nuclear factor 4 alpha", "gene_name": "HNF4A", "organism": "Pig", "refseq_name": "hepatocyte nuclear factor 4-alpha isoform X1", "refseq_ac": "XP_005673008", "gene_names_uniprotkb": "HNF4A", "gene_names_refseq": "HNF-4alpha; 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3.6.1.62; 3.6.1.64; IDP phosphatase; Inosine diphosphate phosphatase; Nucleoside diphosphate-linked moiety X motif 16; m7GpppN-mRNA hydrolase", "protein_names_refseq": "U8 snoRNA-decapping enzyme", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152693); (R-SSC-2393930)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0006402 mRNA catabolic process;GO:0016077 sno(s)RNA catabolic process;GO:0090068 positive regulation of cell cycle process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B383-1", "uniprot_id": "A0A287B383_PIG", "mass": 58865.0, "length": 519, "protein_name": "Serine/threonine-protein kinase RIO3", "gene_name": "RIOK3", "organism": "Pig", "refseq_name": "serine/threonine-protein kinase RIO3 isoform X1", "refseq_ac": "XP_020951836", "gene_names_uniprotkb": "RIOK3", "gene_names_refseq": "RIOK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO3; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase RIO3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100621912)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner. The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1VI84", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0089720 caspase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0030688 preribosome, small subunit precursor;GO:0005737 cytoplasm", "go_biological_process": "GO:0071359 cellular response to dsRNA;GO:0070651 nonfunctional rRNA decay;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B4Y7-1", "uniprot_id": "A0A287B4Y7_PIG", "mass": 40465.0, "length": 360, "protein_name": "Protein Wnt", "gene_name": "WNT2", "organism": "Pig", "refseq_name": "protein Wnt-2", "refseq_ac": "XP_003134804", "gene_names_uniprotkb": "WNT2", "gene_names_refseq": "WNT2", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516839); (R-SSC-3238698)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1W5H1", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B4Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B501-1", "uniprot_id": "A0A287B501_PIG", "mass": 12274.0, "length": 108, "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "organism": "Pig", "refseq_name": "E3 ubiquitin-protein ligase RBX1 isoform X2", "refseq_ac": "XP_020947123", "gene_names_uniprotkb": "RBX1", "gene_names_refseq": "RBX1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RBX1; 2.3.2.32; E3 ubiquitin-protein transferase RBX1; RING finger protein 75; RING-box protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase RBX1 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110314); (R-SSC-1234176); (R-SSC-195253); (R-SSC-4641258); (R-SSC-5632684); (R-SSC-5696394); (R-SSC-5696395); (R-SSC-5696400); (R-SSC-6781823); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-68949); (R-SSC-8854050); (R-SSC-8939902); (R-SSC-8951664); (R-SSC-9708530); (R-SSC-9755511); (R-SSC-983168); (R-SSC-9929491); (R-SSC-9954709)", "pathway_count": 20, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1VWC9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007283 spermatogenesis;GO:0042110 T cell activation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BSF9-1", "uniprot_id": "A0A287BSF9_PIG", "mass": 38918.0, "length": 366, "protein_name": "RISC-loading complex subunit TARBP2", "gene_name": "TARBP2", "organism": "Pig", "refseq_name": "RISC-loading complex subunit TARBP2 isoform X1", "refseq_ac": "XP_003126242", "gene_names_uniprotkb": "TARBP2", "gene_names_refseq": "TARBP2", "protein_names_uniprotkb": "RISC-loading complex subunit TARBP2", "protein_names_refseq": "RISC-loading complex subunit TARBP2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100518071); (R-SSC-203927); (R-SSC-426486); (R-SSC-9833482)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds in vitro to the PRM1 3'-UTR. Seems to act as a repressor of translation. For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1. Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016442 RISC complex", "go_biological_process": "GO:0050689 negative regulation of defense response to virus by host;GO:0070922 RISC complex assembly;GO:0006417 regulation of translation;GO:0031054 pre-miRNA processing;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BSF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B5Y7-1", "uniprot_id": "A0A287B5Y7_PIG", "mass": 65806.0, "length": 571, "protein_name": "E3 ubiquitin-protein ligase RNF168", "gene_name": "RNF168", "organism": "Pig", "refseq_name": "E3 ubiquitin-protein ligase RNF168 isoform X2", "refseq_ac": "XP_020925818", "gene_names_uniprotkb": "RNF168", "gene_names_refseq": "RNF168", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF168 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:110256406); (R-SSC-3108214); (R-SSC-5693565); (R-SSC-5693571); (R-SSC-5693607); (R-SSC-69473)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B5Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B611-1", "uniprot_id": "A0A287B611_PIG", "mass": 261779.0, "length": 2284, "protein_name": "DNA polymerase epsilon catalytic subunit", "gene_name": "POLE", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POLE", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase epsilon catalytic subunit; 2.7.7.7", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110314); (R-SSC-5651801); (R-SSC-5656169); (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5696397); (R-SSC-5696400); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-68952); (R-SSC-68962)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "DNA polymerase II participates in chromosomal DNA replication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B6T9-1", "uniprot_id": "A0A287B6T9_PIG", "mass": 41834.0, "length": 362, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "RSAD2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RSAD2", "gene_names_refseq": "", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; Radical S-adenosyl methionine domain-containing protein 2; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0050709 negative regulation of protein secretion;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B6T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B8K3-1", "uniprot_id": "A0A287B8K3_PIG", "mass": 47984.0, "length": 425, "protein_name": "Pannexin", "gene_name": "PANX1", "organism": "Pig", "refseq_name": "pannexin-1", "refseq_ac": "XP_003482645", "gene_names_uniprotkb": "PANX1; PANX", "gene_names_refseq": "PANX1", "protein_names_uniprotkb": "Pannexin", "protein_names_refseq": "pannexin-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100738603); (R-SSC-112303); (R-SSC-844456)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Structural component of the gap junctions and the hemichannels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0051015 actin filament binding;GO:0005253 monoatomic anion channel activity;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032059 bleb;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006812 monoatomic cation transport;GO:0032731 positive regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287B8K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BA27-1", "uniprot_id": "A0A287BA27_PIG", "mass": 96294.0, "length": 872, "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VLDLR", "gene_names_refseq": "", "protein_names_uniprotkb": "Very low-density lipoprotein receptor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8866376); (R-SSC-8866427)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0034185 apolipoprotein binding;GO:0048306 calcium-dependent protein binding;GO:0001618 virus receptor activity;GO:0030229 very-low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0012505 endomembrane system;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0043235 receptor complex", "go_biological_process": "GO:0006897 endocytosis;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0034436 glycoprotein transport;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BA27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287B9A1-1", "uniprot_id": "A0A287B9A1_PIG", "mass": 30682.0, "length": 284, "protein_name": "Pancreas/duodenum homeobox protein 1", "gene_name": "PDX1", "organism": "Pig", "refseq_name": "pancreas/duodenum homeobox protein 1", "refseq_ac": "NP_001135456", "gene_names_uniprotkb": "PDX1", "gene_names_refseq": "IPF1; PDX-1; PDX1", "protein_names_uniprotkb": "Pancreas/duodenum homeobox protein 1; Insulin promoter factor 1", "protein_names_refseq": "homeodomain protein PDX-1; pancreas/duodenum homeobox protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397288)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24825179;30368976;32543654", "class_list": "", "function": "It is a gene that is crucial for pancreas development during the fetal period and whose monoallelic disruption impairs insulin secretion., [RefSeq, PubMed]; Report pancreatic expression of Pdx-1 in pancreas., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003309 type B pancreatic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A287B9A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480W0Q1-1", "uniprot_id": "A0A480W0Q1_PIG", "mass": 24420.0, "length": 221, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "organism": "Pig", "refseq_name": "inosine triphosphate pyrophosphatase isoform X1", "refseq_ac": "XP_020933236", "gene_names_uniprotkb": "ITPA", "gene_names_refseq": "ITPA", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "inosine triphosphate pyrophosphatase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-74259); (R-SSC-9755088)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BD51", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0035870 dITP diphosphatase activity;GO:0036220 ITP diphosphatase activity;GO:0036222 XTP diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process;GO:0009143 nucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A480W0Q1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BA72-1", "uniprot_id": "A0A287BA72_PIG", "mass": 65124.0, "length": 591, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "SLC27A1", "organism": "Pig", "refseq_name": "long-chain fatty acid transport protein 1 isoform X2", "refseq_ac": "XP_020931804", "gene_names_uniprotkb": "SLC27A1", "gene_names_refseq": "ACSVL5; FATP-1c; SLC27A1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase", "protein_names_refseq": "long-chain fatty acid transport protein 1 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-804914)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell;GO:0044381 glucose import in response to insulin stimulus;GO:0001579 medium-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BA72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BA87-1", "uniprot_id": "A0A287BA87_PIG", "mass": 82229.0, "length": 753, "protein_name": "Solute carrier family 26 member 6", "gene_name": "SLC26A6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC26A6", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 26 member 6", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-427601)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015499 formate transmembrane transporter activity;GO:0030165 PDZ domain binding;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031526 brush border membrane;GO:0012506 vesicle membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0015797 mannitol transmembrane transport;GO:0046724 oxalic acid secretion;GO:0071320 cellular response to cAMP;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BA87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BAF3-1", "uniprot_id": "A0A287BAF3_PIG", "mass": 52960.0, "length": 480, "protein_name": "Adenylosuccinate synthetase isozyme 1", "gene_name": "ADSS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADSS1; ADSSL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 1; 6.3.4.4; AMPSase 1; AdSS 1; Adenylosuccinate synthetase, basic isozyme; Adenylosuccinate synthetase, muscle isozyme; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-73817)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP]; Plays an important role in the de novo pathway of purine nucleotide biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044209 AMP salvage;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BAF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BAM7-1", "uniprot_id": "A0A287BAM7_PIG", "mass": 52409.0, "length": 476, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "ADSS2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADSS2; ADSS", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP, UniProtKB]; Plays an important role in the de novo pathway of purine nucleotide biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BAM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BAQ6-1", "uniprot_id": "A0A287BAQ6_PIG", "mass": 48898.0, "length": 424, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "PTPN1", "organism": "Pig", "refseq_name": "tyrosine-protein phosphatase non-receptor type 1 isoform X1", "refseq_ac": "XP_020932935", "gene_names_uniprotkb": "PTPN1", "gene_names_refseq": "PTP1B; PTPN1", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-354192); (R-SSC-6807004); (R-SSC-77387); (R-SSC-8849472); (R-SSC-912694); (R-SSC-982772); (R-SSC-9860927)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8D0V459", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0030100 regulation of endocytosis;GO:0036498 IRE1-mediated unfolded protein response;GO:0030036 actin cytoskeleton organization;GO:0035791 platelet-derived growth factor receptor-beta signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BAQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BBR7-1", "uniprot_id": "A0A287BBR7_PIG", "mass": 67217.0, "length": 611, "protein_name": "E3 ubiquitin-protein ligase synoviolin", "gene_name": "SYVN1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SYVN1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase synoviolin; 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5358346)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0036513 Derlin-1 retrotranslocation complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination;GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BBR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BBY7-1", "uniprot_id": "A0A287BBY7_PIG", "mass": 40345.0, "length": 373, "protein_name": "Ferroptosis suppressor protein 1", "gene_name": "AIFM2", "organism": "Pig", "refseq_name": "apoptosis-inducing factor 2 isoform X4", "refseq_ac": "XP_005657456", "gene_names_uniprotkb": "AIFM2", "gene_names_refseq": "AIFM2", "protein_names_uniprotkb": "Ferroptosis suppressor protein 1; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; p53-responsive gene 3 protein", "protein_names_refseq": "apoptosis-inducing factor 2 isoform X4", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287B657", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0050660 flavin adenine dinucleotide binding;GO:0004174 electron-transferring-flavoprotein dehydrogenase activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0008637 apoptotic mitochondrial changes;GO:1900407 regulation of cellular response to oxidative stress;GO:0042373 vitamin K metabolic process;GO:0006743 ubiquinone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BBY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BCF1-1", "uniprot_id": "A0A287BCF1_PIG", "mass": 202231.0, "length": 1747, "protein_name": "Kinesin family member 20B", "gene_name": "KIF20B", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KIF20B", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin family member 20B", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6811434); (R-SSC-983189)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0050699 WW domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:1903438 positive regulation of mitotic cytokinetic process;GO:0008284 positive regulation of cell population proliferation;GO:0090316 positive regulation of intracellular protein transport;GO:0048812 neuron projection morphogenesis;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BCF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BCS9-1", "uniprot_id": "A0A287BCS9_PIG", "mass": 40968.0, "length": 347, "protein_name": "Carbohydrate sulfotransferase", "gene_name": "CHST11", "organism": "Pig", "refseq_name": "carbohydrate sulfotransferase 11 isoform X2", "refseq_ac": "XP_020948287", "gene_names_uniprotkb": "CHST11", "gene_names_refseq": "CHST11", "protein_names_uniprotkb": "Carbohydrate sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate sulfotransferase 11 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2022870)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480VHA0;A0A480VKA9;A0A4X1T8D1", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity;GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BCS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BD43-1", "uniprot_id": "A0A287BD43_PIG", "mass": 42391.0, "length": 367, "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "SKAP1", "organism": "Pig", "refseq_name": "src kinase-associated phosphoprotein 1", "refseq_ac": "XP_013835427", "gene_names_uniprotkb": "SKAP1", "gene_names_refseq": "SKAP1", "protein_names_uniprotkb": "Src kinase-associated phosphoprotein 1; Src family-associated phosphoprotein 1", "protein_names_refseq": "src kinase-associated phosphoprotein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521471)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042169 SH2 domain binding;GO:0019903 protein phosphatase binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0002821 positive regulation of adaptive immune response;GO:0033625 positive regulation of integrin activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BD43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BDA9-1", "uniprot_id": "A0A287BDA9_PIG", "mass": 30119.0, "length": 273, "protein_name": "NK2 homeobox 2", "gene_name": "NKX2-2", "organism": "Pig", "refseq_name": "homeobox protein Nkx-2.2 isoform X1", "refseq_ac": "XP_003359963", "gene_names_uniprotkb": "NKX2-2", "gene_names_refseq": "NKX2-2", "protein_names_uniprotkb": "NK2 homeobox 2", "protein_names_refseq": "homeobox protein Nkx-2.2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100626520)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BDA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BDC1-1", "uniprot_id": "AKIR2_PIG", "mass": 22510.0, "length": 203, "protein_name": "Akirin-2", "gene_name": "AKIRIN2", "organism": "Pig", "refseq_name": "akirin-2", "refseq_ac": "NP_001265681", "gene_names_uniprotkb": "AKIRIN2", "gene_names_refseq": "AKIRIN2", "protein_names_uniprotkb": "Akirin-2", "protein_names_refseq": "akirin-2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100519991)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22537061;25686036;28327665;29685038;32543654", "class_list": "", "function": "Akirin2 siRNA abolished arginine-induced upregulation of MyHC I., [RefSeq, PubMed]; Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (PubMed:25686036, PubMed:28327665)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"ec_number_list": "", "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0039706 co-receptor binding;GO:1990459 transferrin receptor binding;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0045177 apical part of cell;GO:0045178 basal part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002725 negative regulation of T cell cytokine production;GO:0006879 intracellular iron ion homeostasis;GO:0030509 BMP signaling pathway;GO:0006898 receptor-mediated endocytosis;GO:0071281 cellular response to iron ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BGV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BHQ4-1", "uniprot_id": "A0A287BHQ4_PIG", "mass": 121187.0, "length": 1116, "protein_name": "Histone deacetylase", "gene_name": "HDAC5", "organism": "Pig", "refseq_name": "histone deacetylase 5 isoform X2", "refseq_ac": "XP_020922550", "gene_names_uniprotkb": "HDAC5", "gene_names_refseq": "HDAC5", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "histone deacetylase 5 isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0042826 histone deacetylase binding;GO:0005080 protein kinase C binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010832 negative regulation of myotube differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BHQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BHR8-1", "uniprot_id": "A0A287BHR8_PIG", "mass": 147497.0, "length": 1302, "protein_name": "Phosphoinositide 3-kinase regulatory subunit 4", "gene_name": "PIK3R4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PIK3R4", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoinositide 3-kinase regulatory subunit 4; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-109704); (R-SSC-1632852); (R-SSC-1660514); (R-SSC-1660516); (R-SSC-1660517); (R-SSC-168138); (R-SSC-5668599)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. 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"protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1502540); (R-SSC-209822); (R-SSC-2473224)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A. Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L., [UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0071944 cell periphery", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0032869 cellular response to insulin stimulus;GO:0009611 response to wounding;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BPF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BPG6-1", "uniprot_id": "A0A287BPG6_PIG", "mass": 125075.0, "length": 1114, "protein_name": "Glutamate receptor", "gene_name": "GRIN3A", "organism": "Pig", "refseq_name": "glutamate receptor ionotropic, NMDA 3A isoform X1", "refseq_ac": "XP_020922555", "gene_names_uniprotkb": "GRIN3A", "gene_names_refseq": "GRIN3A", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 3A isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153054); (R-SSC-9609736)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0016594 glycine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0045471 response to ethanol;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BPG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BPI7-1", "uniprot_id": "A0A287BPI7_PIG", "mass": 94249.0, "length": 860, "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "TGFBR3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFBR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta receptor type 3; Betaglycan; Transforming growth factor beta receptor III", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1502540); (R-SSC-190370); (R-SSC-190373); (R-SSC-201451); (R-SSC-2173789); (R-SSC-9839383); (R-SSC-9839389); (R-SSC-9839397); (R-SSC-9839406)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0005024 transforming growth factor beta receptor activity;GO:0046332 SMAD binding;GO:0050431 transforming growth factor beta binding;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0034673 inhibin-betaglycan-ActRII complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BPI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BPX6-1", "uniprot_id": "A0A287BPX6_PIG", "mass": 102240.0, "length": 901, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP33", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "USP33", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5689880)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031267 small GTPase binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0044297 cell body", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BPX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BPY1-1", "uniprot_id": "A0A287BPY1_PIG", "mass": 101480.0, "length": 901, "protein_name": "Transient receptor potential cation channel subfamily V member 1", "gene_name": "TRPV1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRPV1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 1; Osm-9-like TRP channel 1; Vanilloid receptor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3295583)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0032591 dendritic spine membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0071468 cellular response to acidic pH;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BPY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BRL8-1", "uniprot_id": "A0A287BRL8_PIG", "mass": 31584.0, "length": 332, "protein_name": "Myristoylated alanine-rich C-kinase substrate", "gene_name": "MARCKS", "organism": "Pig", "refseq_name": "myristoylated alanine-rich C-kinase substrate", "refseq_ac": "XP_020947160", "gene_names_uniprotkb": "MARCKS", "gene_names_refseq": "MARCKS", "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate", "protein_names_refseq": "myristoylated alanine-rich C-kinase substrate", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517207); (R-SSC-399997)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0032432 actin filament bundle", "go_biological_process": "GO:0007015 actin filament organization;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0051017 actin filament bundle assembly;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BRL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BRW7-1", "uniprot_id": "A0A287BRW7_PIG", "mass": 31624.0, "length": 314, "protein_name": "Paired like homeobox 2B", "gene_name": "PHOX2B", "organism": "Pig", "refseq_name": "paired mesoderm homeobox protein 2B", "refseq_ac": "XP_020956456", "gene_names_uniprotkb": "PHOX2B", "gene_names_refseq": "PHOX2B", "protein_names_uniprotkb": "Paired like homeobox 2B", "protein_names_refseq": "paired mesoderm homeobox protein 2B", "tax_id": 9823, "disease": "", "pathway": " (ssc:100622938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0003360 brainstem development;GO:0048484 enteric nervous system development;GO:0021723 medullary reticular formation development;GO:0048486 parasympathetic nervous system development;GO:0061452 retrotrapezoid nucleus neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BRW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2C9F398-1", "uniprot_id": "A0A2C9F398_PIG", "mass": 53628.0, "length": 484, "protein_name": "Presenilin", "gene_name": "PSEN2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PSEN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Presenilin; 3.4.23.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005813 centrosome;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction;GO:0042987 amyloid precursor protein catabolic process;GO:0035333 Notch receptor processing, ligand-dependent", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2C9F398-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BSA9-1", "uniprot_id": "A0A287BSA9_PIG", "mass": 59821.0, "length": 527, "protein_name": "Tyrosine-protein kinase", "gene_name": "HCK", "organism": "Pig", "refseq_name": "HCK proto-oncogene, Src family tyrosine kinase", "refseq_ac": "NP_001422630", "gene_names_uniprotkb": "HCK", "gene_names_refseq": "HCK_tv1; HCK", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "HCK proto-oncogene, Src family tyrosine kinase; hemopoietic cell kinase; tyrosine-protein kinase HCK", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2029481); (R-SSC-912631); (R-SSC-9674555); (R-SSC-9705462)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005764 lysosome", "go_biological_process": "GO:0071801 regulation of podosome assembly;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BSA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BSF6-1", "uniprot_id": "A0A287BSF6_PIG", "mass": 68165.0, "length": 595, "protein_name": "Guanylate binding protein 1, interferon-inducible", "gene_name": "GBP1", "organism": "Pig", "refseq_name": "interferon-induced guanylate-binding protein 1 isoform X1", "refseq_ac": "XP_020944162", "gene_names_uniprotkb": "GBP1", "gene_names_refseq": "GBP1", "protein_names_uniprotkb": "Guanylate binding protein 1, interferon-inducible", "protein_names_refseq": "interferon-induced guanylate-binding protein 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9948001); (R-SSC-9953170); (R-SSC-9968551)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle;GO:0012506 vesicle membrane", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0042742 defense response to bacterium;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BSF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A287BTI9-1", "uniprot_id": "A0A287BTI9_PIG", "mass": 51682.0, "length": 464, "protein_name": "Tubby-like protein", "gene_name": "TULP3", "organism": "Pig", "refseq_name": "tubby-related protein 3 isoform X3", "refseq_ac": "XP_005664133", "gene_names_uniprotkb": "TULP3", "gene_names_refseq": "TULP3", "protein_names_uniprotkb": "Tubby-like protein", "protein_names_refseq": "tubby-related protein 3 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5610787)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0001664 G protein-coupled receptor binding;GO:0035091 phosphatidylinositol binding;GO:0120160 intraciliary transport particle A binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0061512 protein localization to cilium;GO:0097499 protein localization to non-motile cilium;GO:0045879 negative regulation of smoothened signaling pathway;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A287BTI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A288CG39-1", "uniprot_id": "A0A288CG39_PIG", "mass": 121394.0, "length": 1054, "protein_name": "Toll-like receptor 9", "gene_name": "TLR7", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TLR7", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor 9", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1679131); (R-SSC-168181); (R-SSC-5686938)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035197 siRNA binding;GO:0045322 unmethylated CpG binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A288CG39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2C9F366-1", "uniprot_id": "A0A2C9F366_PIG", "mass": 25485.0, "length": 231, "protein_name": "Heat shock protein beta-1", "gene_name": "HSPB1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein beta-1; Heat shock 27 kDa protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-4420097); (R-SSC-450408); (R-SSC-5687128); (R-SSC-9009391)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0005080 protein kinase C binding;GO:0008426 protein kinase C inhibitor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0030018 Z disc", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2C9F366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2C9F3B3-1", "uniprot_id": "A0A2C9F3B3_PIG", "mass": 62956.0, "length": 565, "protein_name": "Wee1-like protein kinase", "gene_name": "WEE2", "organism": "Pig", "refseq_name": "wee1-like protein kinase 2 isoform X1", "refseq_ac": "XP_020934065", "gene_names_uniprotkb": "WEE2", "gene_names_refseq": "WEE1B; WEE2", "protein_names_uniprotkb": "Wee1-like protein kinase; 2.7.10.2", "protein_names_refseq": "wee1-like protein kinase 2 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007143 female meiotic nuclear division;GO:0042327 positive regulation of phosphorylation;GO:1900194 negative regulation of oocyte maturation;GO:0035038 female pronucleus assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2C9F3B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2C9F3F6-1", "uniprot_id": "A0A2C9F3F6_PIG", "mass": 43598.0, "length": 407, "protein_name": "Beta-3 adrenergic receptor", "gene_name": "ADRB3", "organism": "Pig", "refseq_name": "beta-3 adrenergic receptor isoform X1", "refseq_ac": "XP_020930350", "gene_names_uniprotkb": "ADRB3", "gene_names_refseq": "ADRB3; BAR3", "protein_names_uniprotkb": "Beta-3 adrenergic receptor; Beta-3 adrenoreceptor", "protein_names_refseq": "beta-3 adrenergic receptor isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-390696)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2C9F3F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A480EKF5-1", "uniprot_id": "A0A480EKF5_PIG", "mass": 49853.0, "length": 461, "protein_name": "Solute carrier family 39 member 8", "gene_name": "SLC39A8", "organism": "Pig", "refseq_name": "zinc transporter ZIP8", "refseq_ac": "XP_013834455", "gene_names_uniprotkb": "SLC39A8", "gene_names_refseq": "SLC39A8", "protein_names_uniprotkb": "Solute carrier family 39 member 8", "protein_names_refseq": "zinc transporter ZIP8", "tax_id": 9823, "disease": "", "pathway": " (ssc:100524695); (R-SSC-442380)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 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"refseq_name": "ubiquitin-conjugating enzyme E2 C", "refseq_ac": "XP_013840876", "gene_names_uniprotkb": "UBE2C", "gene_names_refseq": "UBE2C", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; Ubiquitin carrier protein C; Ubiquitin-protein ligase C", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 C", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153133); (R-SSC-141430); (R-SSC-174048); (R-SSC-174084); (R-SSC-174154); (R-SSC-174178); (R-SSC-174184); (R-SSC-176407); (R-SSC-176408); (R-SSC-176409); (R-SSC-176412); (R-SSC-179409); (R-SSC-2467813); (R-SSC-2559582); (R-SSC-68867); (R-SSC-69017); (R-SSC-8866652); (R-SSC-983168)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SC78", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1U068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UCK3-1", "uniprot_id": "A0A4X1UCK3_PIG", "mass": 50648.0, "length": 453, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "KYAT3", "organism": "Pig", "refseq_name": "kynurenine--oxoglutarate transaminase 3 isoform X2", "refseq_ac": "XP_001929419", "gene_names_uniprotkb": "KYAT3", "gene_names_refseq": "KYAT3", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "kynurenine--oxoglutarate transaminase 3 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157176)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AZB0", "ec_number_list": "", "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047804 cysteine-S-conjugate beta-lyase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006103 2-oxoglutarate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1UCK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1U9R8-1", "uniprot_id": "A0A4X1U9R8_PIG", "mass": 60999.0, "length": 533, "protein_name": "Retinoid isomerohydrolase", "gene_name": "RPE65", "organism": "Pig", "refseq_name": "retinoid isomerohydrolase isoform X1", "refseq_ac": "XP_003127979", "gene_names_uniprotkb": "RPE65", "gene_names_refseq": "RPE65", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase", "protein_names_refseq": "retinoid isomerohydrolase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516743); (R-SSC-2453902)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1S830", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0016853 isomerase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0003834 beta-carotene 15,15'-dioxygenase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007601 visual perception;GO:0001895 retina homeostasis;GO:0042574 retinal metabolic process;GO:0050908 detection of light stimulus involved in visual perception;GO:1901827 zeaxanthin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1U9R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UHU9-1", "uniprot_id": "A0A4X1UHU9_PIG", "mass": 31722.0, "length": 282, "protein_name": "Tumor necrosis factor ligand superfamily member 6", "gene_name": "FASLG", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FASLG", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 6; Fas antigen ligand", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3371378); (R-SSC-5218900); (R-SSC-69416); (R-SSC-75157)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Cytoplasmic form induces gene transcription inhibition., [UniProtKB, UniProtKB]; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I3L6W5", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1UHU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UIB2-1", "uniprot_id": "A0A4X1UIB2_PIG", "mass": 16839.0, "length": 152, "protein_name": "Mitochondrial fission 1 protein", "gene_name": "FIS1", "organism": "Pig", "refseq_name": "mitochondrial fission 1 protein", "refseq_ac": "XP_020941922", "gene_names_uniprotkb": "FIS1", "gene_names_refseq": "FIS1", "protein_names_uniprotkb": "Mitochondrial fission 1 protein", "protein_names_refseq": "mitochondrial fission 1 protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:100622909); (R-SSC-9603798)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287ADK7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016559 peroxisome fission;GO:0006915 apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1UIB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UQ22-1", "uniprot_id": "A0A4X1UQ22_PIG", "mass": 24589.0, "length": 219, "protein_name": "Charged multivesicular body protein 5", "gene_name": "CHMP5", "organism": "Pig", "refseq_name": "charged multivesicular body protein 5", "refseq_ac": "NP_001231673", "gene_names_uniprotkb": "CHMP5", "gene_names_refseq": "CHMP5", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Chromatin-modifying protein 5", "protein_names_refseq": "charged multivesicular body protein 5", "tax_id": 9823, "disease": "", "pathway": " (ssc:100513035); (R-SSC-917729)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SE87", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0097352 autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1UQ22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V695-1", "uniprot_id": "A0A4X1V695_PIG", "mass": 58470.0, "length": 539, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "WRAP53", "organism": "Pig", "refseq_name": "telomerase Cajal body protein 1", "refseq_ac": "XP_003131992", "gene_names_uniprotkb": "WRAP53", "gene_names_refseq": "WRAP53", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79", "protein_names_refseq": "telomerase Cajal body protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522033); (R-SSC-171319); (R-SSC-174430)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1ST42", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0015030 Cajal body;GO:0000781 chromosome, telomeric region;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0006281 DNA repair;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0090666 scaRNA localization to Cajal body;GO:0032203 telomere formation via telomerase;GO:0090671 telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V5H4-1", "uniprot_id": "A0A4X1V5H4_PIG", "mass": 27307.0, "length": 255, "protein_name": "Homeobox protein DLX-1", "gene_name": "DLX1", "organism": "Pig", "refseq_name": "homeobox protein DLX-1 isoform X1", "refseq_ac": "XP_013839737", "gene_names_uniprotkb": "DLX1", "gene_names_refseq": "DLX1", "protein_names_uniprotkb": "Homeobox protein DLX-1", "protein_names_refseq": "homeobox protein DLX-1 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A481C382", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V5H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V8F8-1", "uniprot_id": "A0A4X1V8F8_PIG", "mass": 91941.0, "length": 823, "protein_name": "Neuroligin 1", "gene_name": "NLGN1", "organism": "Pig", "refseq_name": "neuroligin-1 isoform X6", "refseq_ac": "XP_013845595", "gene_names_uniprotkb": "NLGN1", "gene_names_refseq": "NLGN1", "protein_names_uniprotkb": "Neuroligin 1", "protein_names_refseq": "neuroligin-1 isoform X6", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6794361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SH09", "ec_number_list": "", "go_molecular_function": "GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0098793 presynapse;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0072553 terminal button organization;GO:0016080 synaptic vesicle targeting;GO:0048789 cytoskeletal matrix organization at active zone;GO:0097091 synaptic vesicle clustering;GO:0097115 neurexin clustering involved in presynaptic membrane assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V8F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VAW8-1", "uniprot_id": "A0A4X1VAW8_PIG", "mass": 19688.0, "length": 179, "protein_name": "Transcription factor 21", "gene_name": "TCF21", "organism": "Pig", "refseq_name": "transcription factor 21", "refseq_ac": "XP_020943327", "gene_names_uniprotkb": "TCF21", "gene_names_refseq": "TCF21", "protein_names_uniprotkb": "Transcription factor 21", "protein_names_refseq": "transcription factor 21", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152962)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287B8H6", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:0060435 bronchiole development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VAW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1S3M9-1", "uniprot_id": "F1S3M9_PIG", "mass": 110985.0, "length": 995, "protein_name": "Protein 4.1", "gene_name": "EPB41L2", "organism": "Pig", "refseq_name": "band 4.1-like protein 2 isoform X12", "refseq_ac": "XP_020943866", "gene_names_uniprotkb": "EPB41L2", "gene_names_refseq": "EPB41L2", "protein_names_uniprotkb": "Protein 4.1; 4.1R; Band 4.1; Erythrocyte membrane protein band 4.1", "protein_names_refseq": "band 4.1-like protein 2 isoform X12", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6794361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity;GO:0030507 spectrin binding;GO:0042731 PH domain binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030866 cortical actin cytoskeleton organization;GO:0031032 actomyosin structure organization;GO:1904778 positive regulation of protein localization to cell cortex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1S3M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1WCQ0-1", "uniprot_id": "A0A4X1WCQ0_PIG", "mass": 37679.0, "length": 349, "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "GPD1", "organism": "Pig", "refseq_name": "glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "refseq_ac": "NP_001177169", "gene_names_uniprotkb": "GPD1", "gene_names_refseq": "GPD1; cGPD", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase [NAD(+)]; 1.1.1.8", "protein_names_refseq": "cytosolic glycerol-3-phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 1 (soluble); glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153250); (R-SSC-1483166)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20857217;21584730;32543654", "class_list": "", "function": "Has glycerol-3-phosphate dehydrogenase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The full-length genomic sequence of porcine GPD1 gene including promoter region, is reported., [RefSeq, PubMed]; The pig GPD1 gene is regulated negatively by C/EBP beta in cultured kidney cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BDV9", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity;GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0046168 glycerol-3-phosphate catabolic process;GO:0006072 glycerol-3-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A4X1WCQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QCY6-1", "uniprot_id": "A0A5G2QCY6_PIG", "mass": 86846.0, "length": 770, "protein_name": "Phosphodiesterase", "gene_name": "PDE1C", "organism": "Pig", "refseq_name": "calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4", "refseq_ac": "XP_020934867", "gene_names_uniprotkb": "PDE1C", "gene_names_refseq": "PDE1C", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-111957)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QCY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QF04-1", "uniprot_id": "A0A5G2QF04_PIG", "mass": 60816.0, "length": 532, "protein_name": "Amine oxidase [flavin-containing] A", "gene_name": "MAOA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAOA", "gene_names_refseq": "", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] A; 1.4.3.21; 1.4.3.4; Monoamine oxidase type A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-141333); (R-SSC-181430); (R-SSC-379397); (R-SSC-379398); (R-SSC-379401); (R-SSC-380612)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0006584 catecholamine metabolic process;GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QF04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2Q9E7-1", "uniprot_id": "A0A5G2Q9E7_PIG", "mass": 57281.0, "length": 508, "protein_name": "Sodium- and chloride-dependent GABA transporter 2", "gene_name": "SLC6A13", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC6A13", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 2; Solute carrier family 6 member 13", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-442660); (R-SSC-888593)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015293 symporter activity;GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q9E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QGD0-1", "uniprot_id": "A0A5G2QGD0_PIG", "mass": 39586.0, "length": 353, "protein_name": "Eukaryotic translation initiation factor 3 subunit G", "gene_name": "EIF3G", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EIF3G; EIF3S4", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 p42; eIF3 p44; eIF3g", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516956)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QGD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q764M5-1", "uniprot_id": "STAT1_PIG", "mass": 87679.0, "length": 753, "protein_name": "Signal transducer and activator of transcription 1", "gene_name": "STAT1", "organism": "Pig", "refseq_name": "signal transducer and activator of transcription 1", "refseq_ac": "NP_998934", "gene_names_uniprotkb": "STAT1", "gene_names_refseq": "STAT1", "protein_names_uniprotkb": "Signal transducer and activator of transcription 1", "protein_names_refseq": "signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:396655)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14681463;17525118;17565448;18774104;24554650;25357264;27160867;27384656;32543654;37452679", "class_list": "", "function": "Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation., [RefSeq, PubMed]; Cadmium exposure induces necroptosis of porcine spleen via ROS-mediated activation of STAT1/RIPK3 signaling pathway., [RefSeq, PubMed]; Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation., [RefSeq, PubMed]; Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon response by inducing STAT1 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK-STAT1) signaling pathway., [RefSeq, PubMed]; Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 at Ser-727 and STAT1 binding to the caspase-8 promoter in cultured lung endothelial cells., [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6. Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription. Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine., [UniProtKB, UniProtKB, UniProtKB]; Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 nuclear translocation., [RefSeq, PubMed]; This study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BKW1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0072162 metanephric mesenchymal cell differentiation;GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q764M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QL68-1", "uniprot_id": "A0A5G2QL68_PIG", "mass": 97327.0, "length": 865, "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "GPAM", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GPAM", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 1, mitochondrial; 2.3.1.15", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1483166); (R-SSC-75109)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids. Esterifies acyl-group from acyl-coenzyme A (acyl-CoA) to the sn-1 position of glycerol-3-phosphate, to produce lysophosphatidic acid. Has a narrow hydrophobic binding cleft that selects for a linear acyl chain. Catalytic activity is higher for substrates with a 16-carbon acyl chain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0006655 phosphatidylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QL68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00571-1", "uniprot_id": "KAD1_PIG", "mass": 21639.0, "length": 194, "protein_name": "Adenylate kinase isoenzyme 1", "gene_name": "AK1", "organism": "Pig", "refseq_name": "adenylate kinase isoenzyme 1", "refseq_ac": "XP_003122225", "gene_names_uniprotkb": "AK1", "gene_names_refseq": "AK1; Myokinase", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 1; 2.7.4.3; 2.7.4.4; 2.7.4.6; AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase", "protein_names_refseq": "AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; adenylate kinase isoenzyme 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521423)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "2551297;2551298;2832612;2869483;32543654;4366177;4367210", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2551297). Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (PubMed:2551297, PubMed:2551298)., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0047506 dAMP kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001520 outer dense fiber", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046034 ATP metabolic process;GO:0009142 nucleoside triphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00571-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60588-1", "uniprot_id": "PLPP1_PIG", "mass": 32321.0, "length": 285, "protein_name": "Phospholipid phosphatase 1", "gene_name": "PLPP1", "organism": "Pig", "refseq_name": "phospholipid phosphatase 1 isoform 2", "refseq_ac": "XP_003133999", "gene_names_uniprotkb": "PLPP1; LPP1; PPAP2A", "gene_names_refseq": "LPP1; PAP-2a; PAP2-alpha; PAP2a; PLPP1; PPAP2A", "protein_names_uniprotkb": "Phospholipid phosphatase 1; 3.1.3.-; 3.1.3.106; 3.1.3.4; 3.6.1.75; Lipid phosphate phosphohydrolase 1; PAP-2a; PAP2-alpha; PAP2a; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a", "protein_names_refseq": "Lipid phosphate phosphohydrolase 1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; phospholipid phosphatase 1 isoform 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515451); (R-SSC-9845614)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1334090;32543654;8702556", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:1334090, PubMed:8702556, Ref.1). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (By similarity). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (By similarity). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (By similarity). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZIK9", "ec_number_list": "", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0009395 phospholipid catabolic process;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60588-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q45FY6-1", "uniprot_id": "HPRT_PIG", "mass": 24555.0, "length": 218, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "HPRT1", "organism": "Pig", "refseq_name": "hypoxanthine-guanine phosphoribosyltransferase", "refseq_ac": "NP_001027548", "gene_names_uniprotkb": "HPRT1; HPRT", "gene_names_refseq": "HPRT1; HPRT", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; HGPRTase; HGPRT", "protein_names_refseq": "HGPRTase; HGPRT; hypoxanthine-guanine phosphoribosyltransferase 1; hypoxanthine-guanine phosphoribosyltransferase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397351); (R-SSC-74217); (R-SSC-9748787)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0SNU9", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0043103 hypoxanthine salvage;GO:0032264 IMP salvage;GO:0045964 positive regulation of dopamine metabolic process;GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q45FY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TUB2-1", "uniprot_id": "P53_PIG", "mass": 42862.0, "length": 386, "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "organism": "Pig", "refseq_name": "cellular tumor antigen p53", "refseq_ac": "NP_998989", "gene_names_uniprotkb": "TP53; P53", "gene_names_refseq": "P53; TP53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "cellular tumor antigen p53; tumor suppressor p53", "tax_id": 9823, "disease": "", "pathway": " (ssc:397276); (R-SSC-2559580); (R-SSC-2559584); (R-SSC-2559586); (R-SSC-349425); (R-SSC-5689880); (R-SSC-5689896); (R-SSC-5693565); (R-SSC-6804754); (R-SSC-6804756); (R-SSC-6804757); (R-SSC-6804758); (R-SSC-6804759); (R-SSC-6804760); (R-SSC-6811555); (R-SSC-69473); (R-SSC-69481); (R-SSC-69541); (R-SSC-69895); (R-SSC-8852276); (R-SSC-8941855); (R-SSC-9833482)", "pathway_count": 22, "publication_count": 8, "publication_id_list": "10490836;16616078;30473353;30541630;32543654;33603167;33756342;34037422", "class_list": "", "function": "A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs., [RefSeq, PubMed]; CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time., [RefSeq, PubMed]; Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S-Phase and Promotes Viral Replication., [RefSeq, PubMed]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA., [RefSeq, PubMed]; Results demonstrated that p53 may mediate IFN-beta signaling to inhibit viral replication early after Transmissible gastroenteritis virus infection. Erratum:[Vet Microbiol. 2019 Jan;228:261-262. doi: 10.1016/j.vetmic.2018.12.004. PMID: 30573226], [RefSeq, PubMed]; TGFB1 can inhibit Salmonella replication whereas TRP53 can promote Salmonella replication in porcine peripheral blood mononuclear cells and murine macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0005507 copper ion binding;GO:0036310 ATP-dependent DNA/DNA annealing activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9TUB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GKL7-1", "uniprot_id": "ANDR_PIG", "mass": 97127.0, "length": 896, "protein_name": "Androgen receptor", "gene_name": "AR", "organism": "Pig", "refseq_name": "androgen receptor", "refseq_ac": "NP_999479", "gene_names_uniprotkb": "AR; NR3C4", "gene_names_refseq": "AR; NR3C4; SBMA", "protein_names_uniprotkb": "Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4", "protein_names_refseq": "Kennedy disease); androgen receptor (dihydrotestosterone receptor; androgen receptor AR; androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; spinal and bulbar muscular atrophy; testicular feminization", "tax_id": 9823, "disease": "", "pathway": " (ssc:397582)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11086548;15157735;17482664;17553131;22522230;24151599;32543654", "class_list": "", "function": "AR is a potential candidate gene for traits related to pig reproduction and performance, [RefSeq, PubMed]; Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia)., [RefSeq, PubMed]; In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 expression, [RefSeq, PubMed]; Pig ejaculated spermatozoa express androgen receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Presence of AR during gestation in non-gonadal tissues suggests a role of androgen in these tissues, [RefSeq, PubMed]; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1RTM6;Q9GKN9", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0005497 androgen binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9GKL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84024-1", "uniprot_id": "SMAD3_PIG", "mass": 48081.0, "length": 425, "protein_name": "SMAD family member 3", "gene_name": "SMAD3", "organism": "Pig", "refseq_name": "SMAD family member 3", "refseq_ac": "NP_999302", "gene_names_uniprotkb": "SMAD3; MADH3", "gene_names_refseq": "MADH3; SMAD3", "protein_names_uniprotkb": "SMAD family member 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; Mothers against decapentaplegic homolog 3; SMAD 3", "protein_names_refseq": "MAD homolog 3; MAD, mothers against decapentaplegic homolog 3; SMAD 3; SMAD family member 3; mad3; mothers against DPP homolog 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:397260); (R-SSC-1181150); (R-SSC-1502540); (R-SSC-2173788); (R-SSC-2173789); (R-SSC-2173795); (R-SSC-2173796); (R-SSC-5689880); (R-SSC-8941855); (R-SSC-9617828)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "17516505;21965288;27189435;27940052;27996082;32543654", "class_list": "", "function": "Activin A and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 expression., [RefSeq, PubMed]; HSP70 indirectly interacted with Smad3., [RefSeq, PubMed]; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator., [UniProtKB, UniProtKB]; SP1 and SMAD3 are required for high glucose-induced p21(WAF1) gene transcription in LLC-PK1 cells., [RefSeq, PubMed]; Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition, [RefSeq, PubMed]; TAZ confers SMAD3 sensitivity to the smooth muscle actin promoter. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09064;O09144;O14510;O35273;Q92940;Q93002;Q9GKR4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071141 SMAD protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0060395 SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P84024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29055-1", "uniprot_id": "IL10_PIG", "mass": 19934.0, "length": 175, "protein_name": "Interleukin-10", "gene_name": "IL10", "organism": "Pig", "refseq_name": "interleukin-10 precursor", "refseq_ac": "NP_999206", "gene_names_uniprotkb": "IL10", "gene_names_refseq": "CSIF; IL-10; IL10", "protein_names_uniprotkb": "Interleukin-10; CSIF; Cytokine synthesis inhibitory factor; IL-10", "protein_names_refseq": "cytokine synthesis inhibitory factor; interleukin-10 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397106); (R-SSC-6783783)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16817761;17592737;18607788;18700003;23359497;24020676;25614594;27938685;30458998;32543654;7708727", "class_list": "", "function": "Findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery Publication Status: Online-Only, [RefSeq, PubMed]; Immune regulatory cytokine., [UniProtKB, UniProtKB]; In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression., [RefSeq, PubMed]; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis., [RefSeq, PubMed]; Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio., [RefSeq, PubMed]; The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed., [RefSeq, PubMed]; The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported. Publication Status: Online-Only, [RefSeq, PubMed]; The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome), [RefSeq, PubMed]; These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity., [RefSeq, PubMed]; Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1903034 regulation of response to wounding;GO:1903672 positive regulation of sprouting angiogenesis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q29055-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46374-1", "uniprot_id": "TOP2A_PIG", "mass": 174307.0, "length": 1533, "protein_name": "DNA topoisomerase 2-alpha", "gene_name": "TOP2A", "organism": "Pig", "refseq_name": "DNA topoisomerase 2-alpha", "refseq_ac": "NP_999049", "gene_names_uniprotkb": "TOP2A", "gene_names_refseq": "TOP2A; TOPOII", "protein_names_uniprotkb": "DNA topoisomerase 2-alpha; 5.6.2.2; DNA topoisomerase II, alpha isozyme", "protein_names_refseq": "DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) II alpha; topoisomersae II", "tax_id": 9823, "disease": "", "pathway": " (ssc:396917)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0000287 magnesium ion binding;GO:0003682 chromatin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0007059 chromosome segregation;GO:0043065 positive regulation of apoptotic process;GO:0006974 DNA damage response;GO:0030263 apoptotic chromosome condensation;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46374-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02543-1", "uniprot_id": "VIME_PIG", "mass": 53668.0, "length": 466, "protein_name": "Vimentin", "gene_name": "VIM", "organism": "Pig", "refseq_name": "vimentin", "refseq_ac": "XP_005668163", "gene_names_uniprotkb": "VIM", "gene_names_refseq": "VIM", "protein_names_uniprotkb": "Vimentin", "protein_names_refseq": "vimentin", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522394); (R-SSC-264870); (R-SSC-390522); (R-SSC-9013422); (R-SSC-9646399)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "32543654;6628686;6945574;7199625", "class_list": "", "function": "Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front. Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1RWB8;F1RWC0", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:1990254 keratin filament binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005882 intermediate filament;GO:0016363 nuclear matrix", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0045109 intermediate filament organization;GO:0071225 cellular response to muramyl dipeptide;GO:0010634 positive regulation of epithelial cell migration;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46420-1", "uniprot_id": "CP51A_PIG", "mass": 56867.0, "length": 503, "protein_name": "Lanosterol 14-alpha demethylase", "gene_name": "CYP51A1", "organism": "Pig", "refseq_name": "lanosterol 14-alpha demethylase", "refseq_ac": "NP_999597", "gene_names_uniprotkb": "CYP51A1; CYP51", "gene_names_refseq": "CYP51A1; CYP51", "protein_names_uniprotkb": "Lanosterol 14-alpha demethylase; 1.14.14.154; CYP51; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; LDM; Sterol 14-alpha demethylase", "protein_names_refseq": "CYPLI; LDM; cytochrome P450 51A1; cytochrome P450 51; cytochrome P450, family 51, subfamily A, polypeptide 1; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; lanosterol 14-demethylase; sterol 14-alpha demethylase", "tax_id": 9823, "disease": "", "pathway": " (ssc:403334); (R-SSC-211976); (R-SSC-6807047)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10788789;32543654", "class_list": "", "function": "Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008398 sterol 14-demethylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O46420-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QIS7-1", "uniprot_id": "A0A5G2QIS7_PIG", "mass": 158424.0, "length": 1354, "protein_name": "Rho-associated protein kinase", "gene_name": "ROCK1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ROCK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho-associated protein kinase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:397447); (R-SSC-111465); (R-SSC-3928662); (R-SSC-416482); (R-SSC-416572); (R-SSC-4420097); (R-SSC-5627117); (R-SSC-6798695); (R-SSC-8980692); (R-SSC-9013026); (R-SSC-9013106); (R-SSC-9013407); (R-SSC-9013422); (R-SSC-9696264)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0005814 centriole;GO:0001726 ruffle", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:1905205 positive regulation of connective tissue replacement;GO:0022614 membrane to membrane docking;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QIS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VQE6-1", "uniprot_id": "A0A4X1VQE6_PIG", "mass": 27497.0, "length": 238, "protein_name": "Androgen induced 1", "gene_name": "AIG1", "organism": "Pig", "refseq_name": "androgen-induced gene 1 protein isoform X2", "refseq_ac": "XP_020928109", "gene_names_uniprotkb": "AIG1", "gene_names_refseq": "AIG1", "protein_names_uniprotkb": "Androgen induced 1", "protein_names_refseq": "androgen-induced gene 1 protein isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AA02", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VQE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VTA1-1", "uniprot_id": "A0A4X1VTA1_PIG", "mass": 25903.0, "length": 235, "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "AK2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate kinase 2, mitochondrial; 2.7.4.3; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-499943)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QKQ8", "ec_number_list": "", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0019205 nucleobase-containing compound kinase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046034 ATP metabolic process;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VTA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QFB4-1", "uniprot_id": "A0A5G2QFB4_PIG", "mass": 72368.0, "length": 660, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "SLC27A5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC27A5", "gene_names_refseq": "", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-159418); (R-SSC-193368); (R-SSC-193775)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0000166 nucleotide binding;GO:0016874 ligase activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006629 lipid metabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QFB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QE77-1", "uniprot_id": "A0A5G2QE77_PIG", "mass": 95102.0, "length": 846, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase", "gene_name": "MAP4K5", "organism": "Pig", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 5 isoform X1", "refseq_ac": "XP_020957192", "gene_names_uniprotkb": "MAP4K5", "gene_names_refseq": "MAP4K5", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase; 2.7.11.1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase kinase 5 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:102161529)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QE77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QDP6-1", "uniprot_id": "A0A5G2QDP6_PIG", "mass": 32124.0, "length": 286, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "gene_name": "CD38", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CD38", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 3.2.2.6; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-196807)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016740 transferase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016849 phosphorus-oxygen lyase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QDP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1WAV2-1", "uniprot_id": "A0A4X1WAV2_PIG", "mass": 44449.0, "length": 402, "protein_name": "ELAV-like protein", "gene_name": "ELAVL4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ELAVL4", "gene_names_refseq": "", "protein_names_uniprotkb": "ELAV-like protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2R9B9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0140517 protein-RNA adaptor activity;GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0008143 poly(A) binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043204 perikaryon;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0006396 RNA processing;GO:1905870 positive regulation of 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1WAV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52NJ4-1", "uniprot_id": "ARL3_PIG", "mass": 20484.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "ARL3", "organism": "Pig", "refseq_name": "ADP-ribosylation factor-like protein 3", "refseq_ac": "NP_001026955", "gene_names_uniprotkb": "ARL3", "gene_names_refseq": "ARL3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like protein 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:595114)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005929 cilium", "go_biological_process": "GO:0015031 protein transport;GO:0001822 kidney development;GO:0007264 small GTPase-mediated signal transduction;GO:0060271 cilium assembly;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q52NJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55944-1", "uniprot_id": "MT3_PIG", "mass": 6927.0, "length": 68, "protein_name": "Metallothionein-3", "gene_name": "MT3", "organism": "Pig", "refseq_name": "metallothionein-3", "refseq_ac": "NP_999221", "gene_names_uniprotkb": "MT3", "gene_names_refseq": "MT-III; MT3", "protein_names_uniprotkb": "Metallothionein-3; GIF; Growth inhibitory factor; MT-3; MT-III; Metallothionein-III", "protein_names_refseq": "GIF; MT-3; growth inhibitory factor; metallothionein-3; metallothionein-III", "tax_id": 9823, "disease": "", "pathway": " (ssc:397123); (R-SSC-5661231)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "27049121;32543654;8896330;9426250", "class_list": "", "function": "Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity)., [UniProtKB]; Expression of MT-1a, MT-2b and MT-3 were significantly higher in high zinc fed pigs., [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0008021 synaptic vesicle;GO:0016234 inclusion body", "go_biological_process": "GO:0006829 zinc ion transport;GO:0001934 positive regulation of protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00355-1", "uniprot_id": "G3P_PIG", "mass": 35836.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "GAPDH", "organism": "Pig", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase", "refseq_ac": "NP_001193288", "gene_names_uniprotkb": "GAPDH; GAPD", "gene_names_refseq": "GAPDH; GAPD", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 9823, "disease": "", "pathway": " (ssc:396823)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1201027;18671919;32543654;4299800;9241041", "class_list": "", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. Also shows nitrosylase activity, thereby playing a role in nuclear functions (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18816;P79299;P79317;Q29546", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0097718 disordered domain specific binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050821 protein stabilization;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4R1H1-1", "uniprot_id": "TYRP2_PIG", "mass": 58573.0, "length": 519, "protein_name": "L-dopachrome tautomerase", "gene_name": "DCT", "organism": "Pig", "refseq_name": "L-dopachrome tautomerase precursor", "refseq_ac": "NP_001020398", "gene_names_uniprotkb": "DCT; TYRP2", "gene_names_refseq": "DCT", "protein_names_uniprotkb": "L-dopachrome tautomerase; 5.3.3.12; DCT; DT; L-dopachrome Delta-isomerase; TRP-2; TRP2; Tyrosinase-related protein 2", "protein_names_refseq": "DT; L-dopachrome Delta-isomerase; L-dopachrome tautomerase precursor; L-dopachrome tautomerase; TRP-2; TRP2; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); dorpachrome tautomerase; tyrosinase-related protein 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:574066); (R-SSC-5662702)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16293128;32543654", "class_list": "", "function": "Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0004167 dopachrome isomerase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0002052 positive regulation of neuroblast proliferation;GO:0048066 developmental pigmentation;GO:0021847 ventricular zone neuroblast division;GO:0006583 melanin biosynthetic process from tyrosine;GO:0009637 response to blue light", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4R1H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16225-1", "uniprot_id": "SPAI_PIG", "mass": 20471.0, "length": 187, "protein_name": "Sodium/potassium ATPase inhibitor SPAI-2", "gene_name": "SPAI-2", "organism": "Pig", "refseq_name": "sodium/potassium ATPase inhibitor SPAI-2 precursor", "refseq_ac": "NP_001004032", "gene_names_uniprotkb": "SPAI-2", "gene_names_refseq": "SPAI-2; WAP-2", "protein_names_uniprotkb": "Sodium/potassium ATPase inhibitor SPAI-2; Protein WAP-2", "protein_names_refseq": "elafin family member; protein WAP-2; sodium/potassium ATPase inhibitor SPAI-2 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:445518)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2171523;2553020;32543654;7673229;8636131", "class_list": "", "function": "Inhibits Na(+),K(+) ATPase by the competitive mode against Na(+)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0007620 copulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P16225-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QCE4-1", "uniprot_id": "A0A5G2QCE4_PIG", "mass": 493646.0, "length": 4312, "protein_name": "Cytoplasmic dynein 2 heavy chain 1", "gene_name": "DYNC2H1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DYNC2H1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytoplasmic dynein 2 heavy chain 1; Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain isotype 1B", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding;GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity", "go_cellular_component": "GO:0030286 dynein complex;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005930 axoneme;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0030030 cell projection organization;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QCE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29024-1", "uniprot_id": "DX39B_PIG", "mass": 48991.0, "length": 428, "protein_name": "Spliceosome RNA helicase DDX39B", "gene_name": "DDX39B", "organism": "Pig", "refseq_name": "spliceosome RNA helicase DDX39B", "refseq_ac": "NP_001005157", "gene_names_uniprotkb": "DDX39B; BAT1; UAP56", "gene_names_refseq": "BAT1; DDX39B", "protein_names_uniprotkb": "Spliceosome RNA helicase DDX39B; 3.6.4.13; 56 kDa U2AF65-associated protein; DEAD box protein UAP56", "protein_names_refseq": "56 kDa U2AF65-associated protein; DEAD box protein UAP56; DEAD-box helicase 39B; HLA-B associated transcript 1; spliceosome RNA helicase BAT1; spliceosome RNA helicase DDX39B", "tax_id": 9823, "disease": "", "pathway": " (ssc:448813); (R-SSC-159236); (R-SSC-72163); (R-SSC-72187); (R-SSC-9013418)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11169259;32543654;7601445", "class_list": "", "function": "Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B. Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability., [UniProtKB, UniProtKB]; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0030621 U4 snRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0000346 transcription export complex;GO:0005687 U4 snRNP", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q29024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50133-1", "uniprot_id": "PTH1R_PIG", "mass": 65682.0, "length": 585, "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "PTH1R", "organism": "Pig", "refseq_name": "parathyroid hormone/parathyroid hormone-related peptide receptor precursor", "refseq_ac": "NP_999547", "gene_names_uniprotkb": "PTH1R; PTHR1; PTHR", "gene_names_refseq": "PTH1R; PTHR1; PTHR; PTH", "protein_names_uniprotkb": "Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Parathyroid hormone 1 receptor", "protein_names_refseq": "PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor precursor; parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397675)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19608645;19646152;23196707;32543654;8688470", "class_list": "", "function": "G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:8688470). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity)., [UniProtKB, PubMed, UniProtKB]; G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH., [UniProtKB, UniProtKB, UniProtKB]; PTHLH and PTHR1 were evaluated as functional candidate genes for their effects on number and shape of teats in pigs, [RefSeq, PubMed]; These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells., [RefSeq, PubMed]; This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 and PTH1R with some of leg weakness related traits in pigs., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0017046 peptide hormone binding;GO:0004991 parathyroid hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RK46-1", "uniprot_id": "F1RK46_PIG", "mass": 264388.0, "length": 2440, "protein_name": "histone acetyltransferase", "gene_name": "CREBBP", "organism": "Pig", "refseq_name": "CREB-binding protein", "refseq_ac": "XP_005662241", "gene_names_uniprotkb": "CREBBP", "gene_names_refseq": "CREBBP", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "CREB-binding protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:100620215); (R-SSC-1234158); (R-SSC-201722); (R-SSC-3134973); (R-SSC-3371568); (R-SSC-350054); (R-SSC-5621575); (R-SSC-8866907); (R-SSC-8939246); (R-SSC-8941856); (R-SSC-9018519); (R-SSC-933541); (R-SSC-9617629); (R-SSC-9759194); (R-SSC-9841922); (R-SSC-9856649)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0140297 DNA-binding transcription factor binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:2000819 regulation of nucleotide-excision repair;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RK46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14082-1", "uniprot_id": "BDNF_PIG", "mass": 28287.0, "length": 252, "protein_name": "Neurotrophic factor BDNF precursor form", "gene_name": "BDNF", "organism": "Pig", "refseq_name": "neurotrophic factor BDNF precursor form precursor", "refseq_ac": "NP_999424", "gene_names_uniprotkb": "BDNF", "gene_names_refseq": "BDNF", "protein_names_uniprotkb": "Neurotrophic factor BDNF precursor form; Brain-derived neurotrophic factor; proBDNF", "protein_names_refseq": "neurotrophic factor BDNF precursor form precursor; neurotrophic factor BDNF precursor form; proBDNF", "tax_id": 9823, "disease": "", "pathway": " (ssc:397495); (R-SSC-1257604); (R-SSC-6811558); (R-SSC-9026527); (R-SSC-9028731); (R-SSC-9032759)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "21151608;22584108;25146846;2779653;30007130;32543654", "class_list": "", "function": "During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS., [UniProtKB, UniProtKB]; FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF Publication Status: Online-Only, [RefSeq, PubMed]; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse., [UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability., [UniProtKB, UniProtKB]; Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway., [RefSeq, PubMed]; Measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals, [RefSeq, PubMed]; Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0008021 synaptic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1RPP5-1", "uniprot_id": "S22A7_PIG", "mass": 59844.0, "length": 547, "protein_name": "Solute carrier family 22 member 7", "gene_name": "SLC22A7", "organism": "Pig", "refseq_name": "solute carrier family 22 member 7", "refseq_ac": "NP_001038082", "gene_names_uniprotkb": "SLC22A7; OAT2", "gene_names_refseq": "OAT2; SLC22A7", "protein_names_uniprotkb": "Solute carrier family 22 member 7; Organic anion transporter 2", "protein_names_refseq": "renal organic anion transporter 2; solute carrier family 22 member 7", "tax_id": 9823, "disease": "", "pathway": " (ssc:733693); (R-SSC-561048); (R-SSC-9749641)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Functions as a Na(+)-independent bidirectional multispecific transporter. Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively. Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates. Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways. Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine. Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion. Also transports alpha-ketoglutarate and urate. Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015742 alpha-ketoglutarate transport;GO:0015732 prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RPP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UWS6-1", "uniprot_id": "A0A4X1UWS6_PIG", "mass": 84496.0, "length": 746, "protein_name": "Phosphodiesterase", "gene_name": "PDE4D", "organism": "Pig", "refseq_name": "cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3", "refseq_ac": "XP_020932533", "gene_names_uniprotkb": "PDE4D", "gene_names_refseq": "PDE4D", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-180024); (R-SSC-418555); (R-SSC-9860927)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZKE1", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0044325 transmembrane transporter binding;GO:0097110 scaffold protein binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0050852 T cell receptor signaling pathway;GO:0032729 positive regulation of type II interferon production;GO:0032743 positive regulation of interleukin-2 production;GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1UWS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TTJ7-1", "uniprot_id": "KCNQ1_PIG", "mass": 74032.0, "length": 673, "protein_name": "Potassium voltage-gated channel subfamily KQT member 1", "gene_name": "KCNQ1", "organism": "Pig", "refseq_name": "potassium voltage-gated channel subfamily KQT member 1", "refseq_ac": "XP_020938278", "gene_names_uniprotkb": "KCNQ1; KVLQT1", "gene_names_refseq": "KCNQ1; KVLQT1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1", "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; ovarian voltage-gated K+ channel pore-forming subunit KCNQ1; potassium channel protein (KvLQT1); potassium voltage-gated channel subfamily KQT member 1-like; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; ventricular voltage-gated K+ channel pore-forming subunit KCNQ1; voltage-gated potassium channel subunit Kv7.1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397326)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30723633;32543654", "class_list": "", "function": "Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A438", "ec_number_list": "", "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0034236 protein kinase A catalytic subunit binding;GO:0015271 outward rectifier potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0060453 regulation of gastric acid secretion;GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0030644 intracellular chloride ion homeostasis;GO:0035934 corticosterone secretion;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9TTJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00339-1", "uniprot_id": "LDHA_PIG", "mass": 36619.0, "length": 332, "protein_name": "L-lactate dehydrogenase A chain", "gene_name": "LDHA", "organism": "Pig", "refseq_name": "L-lactate dehydrogenase A chain isoform X3", "refseq_ac": "XP_020937314", "gene_names_uniprotkb": "LDHA", "gene_names_refseq": "LDH-A; LDH-M; LDHA", "protein_names_uniprotkb": "L-lactate dehydrogenase A chain; 1.1.1.27; LDH muscle subunit; LDH-A; LDH-M", "protein_names_refseq": "L-lactate dehydrogenase A chain isoform X3", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1678537;32543654;7937776;838465", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QCU4-1", "uniprot_id": "A0A5G2QCU4_PIG", "mass": 135480.0, "length": 1292, "protein_name": "EMILIN-1", "gene_name": "EMILIN1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EMILIN1", "gene_names_refseq": "", "protein_names_uniprotkb": "EMILIN-1; Elastin microfibril interface-located protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2129379)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0098640 integrin binding involved in cell-matrix adhesion;GO:0030023 extracellular matrix constituent conferring elasticity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034668 integrin alpha4-beta1 complex;GO:1990971 EMILIN complex", "go_biological_process": "GO:0050866 negative regulation of cell activation;GO:1905522 negative regulation of macrophage migration;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QCU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29406-1", "uniprot_id": "LEP_PIG", "mass": 18661.0, "length": 167, "protein_name": "Leptin", "gene_name": "LEP", "organism": "Pig", "refseq_name": "leptin isoform 1 precursor", "refseq_ac": "NP_999005", "gene_names_uniprotkb": "LEP; OBS; OB", "gene_names_refseq": "LEP; OBS; OB", "protein_names_uniprotkb": "Leptin; Obesity factor", "protein_names_refseq": "leptin isoform 1 precursor; obese; obesity factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396832)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11147346;25380469;25910874;27264891;32543654;32708964;34066779;8856925;9498356", "class_list": "", "function": "A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia., [RefSeq, PubMed]; Evaluation of Fat Accumulation and Adipokine Production during the Long-Term Adipogenic Differentiation of Porcine Intramuscular Preadipocytes and Study of the Influence of Immunobiotics. Publication Status: Online-Only, [RefSeq, PubMed]; Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity? Publication Status: Online-Only, [RefSeq, PubMed]; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 which promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits., [RefSeq, PubMed]; The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O19095;Q95251", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005179 hormone activity;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0019953 sexual reproduction;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q29406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QET9-1", "uniprot_id": "A0A5G2QET9_PIG", "mass": 125592.0, "length": 1127, "protein_name": "DNA polymerase", "gene_name": "POLD1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POLD1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase; 2.7.7.7", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110314); (R-SSC-174411); (R-SSC-174414); (R-SSC-174417); (R-SSC-174437); (R-SSC-5358565); (R-SSC-5358606); (R-SSC-5651801); (R-SSC-5656169); (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5696397); (R-SSC-5696400); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-69091); (R-SSC-69166); (R-SSC-69183)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0000109 nucleotide-excision repair complex;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QET9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W3F8-1", "uniprot_id": "A0A4X1W3F8_PIG", "mass": 57611.0, "length": 524, "protein_name": "Alkaline phosphatase", "gene_name": "ALPL", "organism": "Pig", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme isoform X2", "refseq_ac": "XP_020953341", "gene_names_uniprotkb": "ALPL", "gene_names_refseq": "ALPL", "protein_names_uniprotkb": "Alkaline phosphatase; 3.1.3.1", "protein_names_refseq": "alkaline phosphatase, tissue-nonspecific isozyme isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100170147); (R-SSC-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BR46", "ec_number_list": "", "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0031214 biomineral tissue development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W3F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29040-1", "uniprot_id": "ESR1_PIG", "mass": 66361.0, "length": 595, "protein_name": "Estrogen receptor", "gene_name": "ESR1", "organism": "Pig", "refseq_name": "estrogen receptor", "refseq_ac": "NP_999385", "gene_names_uniprotkb": "ESR1; ESR; NR3A1", "gene_names_refseq": "ER-alpha; ESR1", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "ER; estradiol receptor; estrogen receptor alpha; estrogen receptor; nuclear receptor subfamily 3 group A member 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397435); (R-SSC-1251985); (R-SSC-1257604); (R-SSC-383280); (R-SSC-4090294); (R-SSC-5689896); (R-SSC-6811558); (R-SSC-8866910); (R-SSC-8931987); (R-SSC-8939211); (R-SSC-9009391); (R-SSC-9018519); (R-SSC-9841251)", "pathway_count": 13, "publication_count": 11, "publication_id_list": "15943697;16249893;20576168;21944540;30178695;32543654;33977374;34248262;7635163;7988744;8458437", "class_list": "", "function": "Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs. Publication Status: Online-Only, [RefSeq, PubMed]; ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII and stage I of the seminiferous epithelial cycle, but not in other cells., [RefSeq, PubMed]; ESR(B), FSHbeta(B), CTNNAL1(G), miR-27a(A) allele was favorable for litter size traits. Furthermore, combined genetic effect analysis showed ESR(AA)FSHbeta(BB), ESR(AA)CTNNAL1(CG), ESR(AA)miR-27a(AA), FSHbeta(BB)CTNNAL1(CC), FSHbeta(BB)miR-27a(AA) and CTNNAL1(CG) miR-27a(AB) was the favorable combined genotype for litter size traits., [RefSeq, PubMed]; Evaluation of reproductive traits and ovarian and uterine morphology of sows with different genotypes for the estrogen receptor, prolactin receptor, and follicle-stimulating hormone subunit beta genes., [RefSeq, PubMed]; Findings suggest that testicular estrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar., [RefSeq, PubMed]; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity)., [UniProtKB, UniProtKB]; The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. Publication Status: Online-Only, [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., [UniProtKB, UniProtKB]; These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0034056 estrogen response element binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010629 negative regulation of gene expression;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q29040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16545-1", "uniprot_id": "IGF1_PIG", "mass": 17010.0, "length": 153, "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "organism": "Pig", "refseq_name": "insulin-like growth factor 1 precursor", "refseq_ac": "NP_999421", "gene_names_uniprotkb": "IGF1; IGF-1", "gene_names_refseq": "IGF-1; IGF-I; IGF1; Npt2B", "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; Somatomedin", "protein_names_refseq": "insulin-like growth factor 1 precursor; insulin-like growth factor I; somatomedin C", "tax_id": 9823, "disease": "", "pathway": " (ssc:397491)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "2326169;30196890;30945114;3211153;32171113;32543654;32586423;34356043;8297476", "class_list": "", "function": "A SNP in the 3'UTR of the porcine IGF-1 gene interacts with miR-new14 to affect IGF-1 expression, proliferation and apoptosis of PK-15 cells., [RefSeq, PubMed]; CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus. Publication Status: Online-Only, [RefSeq, PubMed]; High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio., [RefSeq, PubMed]; Role of Akt and mammalian target of rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This finding confirmed that miR-511 inhibits proliferation and promotes apoptosis by downregulating the IGF-1 in PK-15 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0005158 insulin receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070382 exocytic vesicle;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0034392 negative regulation of smooth muscle cell apoptotic process;GO:0045725 positive regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16545-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49927-1", "uniprot_id": "PRIO_PIG", "mass": 27727.0, "length": 257, "protein_name": "Major prion protein", "gene_name": "PRNP", "organism": "Pig", "refseq_name": "major prion protein precursor", "refseq_ac": "NP_001008687", "gene_names_uniprotkb": "PRNP; PRP", "gene_names_refseq": "PRNP; PRP", "protein_names_uniprotkb": "Major prion protein; PrP", "protein_names_refseq": "major prion protein precursor; major prion protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:494014)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15647367;15943782;32543654;7727546", "class_list": "", "function": "Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Single nucleotide polymorphisms (G11A, G615C, G684A, T726G) in the open reading frame of the porcine PRNP gene were found, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0045121 membrane raft", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051260 protein homooligomerization;GO:1904646 cellular response to amyloid-beta;GO:0050850 positive regulation of calcium-mediated signaling;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26234-1", "uniprot_id": "VINC_PIG", "mass": 123945.0, "length": 1135, "protein_name": "Vinculin", "gene_name": "VCL", "organism": "Pig", "refseq_name": "vinculin", "refseq_ac": "NP_999099", "gene_names_uniprotkb": "VCL", "gene_names_refseq": "VCL; VIN", "protein_names_uniprotkb": "Vinculin; Metavinculin", "protein_names_refseq": "metavinculin; vinculin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396974); (R-SSC-114608); (R-SSC-445355); (R-SSC-5674135); (R-SSC-6798695); (R-SSC-9764561); (R-SSC-9856530); (R-SSC-9860927); (R-SSC-9958825)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "17664339;3142762;32543654;8425604", "class_list": "", "function": "Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that myosin VI and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8WMK3", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding;GO:0005198 structural molecule activity;GO:0002162 dystroglycan binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0090636 outer dense plaque of desmosome;GO:0090637 inner dense plaque of desmosome;GO:0061826 podosome ring;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043297 apical junction assembly;GO:0051893 regulation of focal adhesion assembly;GO:1903140 regulation of establishment of endothelial barrier;GO:0007155 cell adhesion;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26234-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34994-1", "uniprot_id": "SSR2_PIG", "mass": 41219.0, "length": 369, "protein_name": "Somatostatin receptor type 2", "gene_name": "SSTR2", "organism": "Pig", "refseq_name": "somatostatin receptor type 2", "refseq_ac": "NP_001011694", "gene_names_uniprotkb": "SSTR2", "gene_names_refseq": "SSTR2", "protein_names_uniprotkb": "Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R", "protein_names_refseq": "SRIF-1; SS-2-R; SS2-R; SS2R; somatostatin receptor type 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:497059)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12646058;17053026;18289730;32543654;8123027", "class_list": "", "function": "Data demonstrate that urotensin II and urotensin II-related peptide directly activate somatostatin receptors 2 and 5 and thus mimic the effect of somatostatin on its cognate receptors., [RefSeq, PubMed]; Is a potent inhibitory receptor displaying a unique set of interrelated dynamic features of agonist-dependent dimerization, dissociation, internalization, and reassociation, a cascade of events that might be critical for receptor function, [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization., [UniProtKB, UniProtKB, UniProtKB]; SRIF can inhibit testosterone secretion through the sst2A receptor; local inhibitory action of SRIF is probably autocrine & might involve testosterone-induced increase of sst2 receptor expression in immature Leydig cells [SST2A] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0060125 negative regulation of growth hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P34994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QET6-1", "uniprot_id": "A0A5G2QET6_PIG", "mass": 69485.0, "length": 624, "protein_name": "Prolactin receptor", "gene_name": "PRLR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRLR", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin receptor; PRL-R", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1170546); (R-SSC-982772)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004925 prolactin receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0019221 cytokine-mediated signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QET6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22411-1", "uniprot_id": "DPP4_PIG", "mass": 88242.0, "length": 766, "protein_name": "Dipeptidyl peptidase 4", "gene_name": "DPP4", "organism": "Pig", "refseq_name": "dipeptidyl peptidase 4", "refseq_ac": "NP_999422", "gene_names_uniprotkb": "DPP4; CD26", "gene_names_refseq": "ADABP; CD26; DPP4; DPPIV", "protein_names_uniprotkb": "Dipeptidyl peptidase 4; 3.4.14.5; DPP IV; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase IV; T-cell activation antigen CD26", "protein_names_refseq": "DPP IV; T-cell activation antigen CD26; dipeptidyl peptidase 4; dipeptidyl peptidase IV; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); dipeptidyl-peptidase iv", "tax_id": 9823, "disease": "", "pathway": " (ssc:397492)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12690074;14719797;16025254;16700514;1675855;21093607;25828735;32543654;7903569", "class_list": "", "function": "Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:14719797). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)., [UniProtKB, UniProtKB, PubMed]; DPP-IV from porcine kidney cortex was characterized., [RefSeq, PubMed]; Neutral endopeptidase 24.11 and DPP-IV is superior to DPP-IV inhibition alone in preserving intact GLP-1, which implies possibility that the combination has therapeutic potential., [RefSeq, PubMed]; Results describe the distribution of dipeptidyl peptidase IV-like activity enzymes in porcine tissue sections by RT-PCR., [RefSeq, PubMed]; This study shows that porcine DPP-IV is generally inhibited with greater potency by protein-derived peptides than is the human enzyme, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q866G2", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0031295 T cell costimulation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P22411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12026-1", "uniprot_id": "ACBP_PIG", "mass": 9896.0, "length": 87, "protein_name": "Acyl-CoA-binding protein", "gene_name": "DBI", "organism": "Pig", "refseq_name": "acyl-CoA-binding protein", "refseq_ac": "NP_999284", "gene_names_uniprotkb": "DBI", "gene_names_refseq": "DBI", "protein_names_uniprotkb": "Acyl-CoA-binding protein; ACBP; DBI; Diazepam-binding inhibitor; EP; Endozepine", "protein_names_refseq": "ACBP; EP; acyl-CoA-binding protein; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam-binding inhibitor; endozepine", "tax_id": 9823, "disease": "", "pathway": " (ssc:397212)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "32543654;3289918;8375398", "class_list": "", "function": "Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor., [UniProtKB]; DBI(32-86) has antibacterial properties., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YB23;Q9TSG2", "ec_number_list": "", "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0042802 identical protein binding;GO:0036042 long-chain fatty acyl-CoA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0032994 protein-lipid complex", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:2001140 positive regulation of phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P12026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52NJ1-1", "uniprot_id": "RB11A_PIG", "mass": 24394.0, "length": 216, "protein_name": "Ras-related protein Rab-11A", "gene_name": "RAB11A", "organism": "Pig", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": "NP_001026958", "gene_names_uniprotkb": "RAB11A; RAB11", "gene_names_refseq": "RAB11A; Rab-11", "protein_names_uniprotkb": "Ras-related protein Rab-11A; 3.6.5.2; Rab-11", "protein_names_refseq": "ras-related protein Rab-11A", "tax_id": 9823, "disease": "", "pathway": " (ssc:595117); (R-SSC-432040); (R-SSC-5620912); (R-SSC-5620916); (R-SSC-8854214)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "28822762;32543654", "class_list": "", "function": "Rab11a promotes Porcine reproductive and respiratory syndrome virus (PRRSV) replication and associates with PRRSV replication sites., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0000922 spindle pole", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:1903438 positive regulation of mitotic cytokinetic process;GO:1990182 exosomal secretion;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0072594 establishment of protein localization to organelle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q52NJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61292-1", "uniprot_id": "PP1B_PIG", "mass": 37187.0, "length": 327, "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "PPP1CB", "organism": "Pig", "refseq_name": "serine/threonine-protein phosphatase PP1-beta catalytic subunit", "refseq_ac": "NP_999349", "gene_names_uniprotkb": "PPP1CB", "gene_names_refseq": "PPP1CB", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit; 3.1.3.16; 3.1.3.53; PP-1B", "protein_names_refseq": "PP-1B; protein phosphatase-1 delta; serine/threonine-protein phosphatase PP1-beta catalytic subunit", "tax_id": 9823, "disease": "", "pathway": " (ssc:397378); (R-SSC-2565942); (R-SSC-5625740); (R-SSC-5627123); (R-SSC-5673000); (R-SSC-9770562)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "16820860;17215279;30934875;32543654", "class_list": "", "function": "Cloning and expression profile of PPP1CB; part of the genomic sequence and polymorphisms were cloned and characterized, [RefSeq, PubMed]; Overall, these data suggest that the Classical swine fever virus E2 protein and swine PPP1CB protein interact in infected cells, and that activation of the PP1 pathway decreases virus replication. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q20BD5", "ec_number_list": "", "go_molecular_function": "GO:0050115 myosin-light-chain-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0017018 myosin phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61292-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N1F5-1", "uniprot_id": "GSTO1_PIG", "mass": 27419.0, "length": 241, "protein_name": "Glutathione S-transferase omega-1", "gene_name": "GSTO1", "organism": "Pig", "refseq_name": "glutathione S-transferase omega-1", "refseq_ac": "NP_999215", "gene_names_uniprotkb": "GSTO1", "gene_names_refseq": "GSTO 1-1; GSTO1; SPG-R", "protein_names_uniprotkb": "Glutathione S-transferase omega-1; 1.20.4.2; 1.8.5.1; 2.5.1.18; GSTO 1-1; GSTO-1; Glutathione S-transferase omega 1-1; Glutathione-dependent dehydroascorbate reductase; MMA(V) reductase; Monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; SPG-R", "protein_names_refseq": "GSTO-1; MMA(V) reductase; S-(Phenacyl)glutathione reductase; glutathione S-transferase omega 1-1; glutathione S-transferase omega-1; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397117); (R-SSC-156581); (R-SSC-156590); (R-SSC-196836)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11485575;32543654", "class_list": "", "function": "Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)., [UniProtKB, UniProtKB]; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016491 oxidoreductase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0050610 methylarsonate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019852 L-ascorbic acid metabolic process;GO:0071243 cellular response to arsenic-containing substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9N1F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29307-1", "uniprot_id": "ATIF1_PIG", "mass": 12184.0, "length": 108, "protein_name": "ATPase inhibitor, mitochondrial", "gene_name": "ATP5IF1", "organism": "Pig", "refseq_name": "ATPase inhibitor, mitochondrial precursor", "refseq_ac": "NP_001090955", "gene_names_uniprotkb": "ATP5IF1; ATPIF1; ATPI", "gene_names_refseq": "ATP5IF1; ATPIF1", "protein_names_uniprotkb": "ATPase inhibitor, mitochondrial; ATP synthase F1 subunit epsilon; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase", "protein_names_refseq": "ATP synthase F1 subunit epsilon; ATPase inhibitor, mitochondrial precursor; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; IF(1); IF1; inhibitor of F(1)F(o)-ATPase; mitochondrial ATPIF1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100038002)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32543654;8672129", "class_list": "", "function": "Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1XQV8", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0043532 angiostatin binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0002931 response to ischemia;GO:0030218 erythrocyte differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0051882 mitochondrial depolarization;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63246-1", "uniprot_id": "RACK1_PIG", "mass": 35077.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "organism": "Pig", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": "NP_999497", "gene_names_uniprotkb": "RACK1; GNB2L1", "gene_names_refseq": "RACK1", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor for activated C kinase; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1", "protein_names_refseq": "G-beta like protein; guanine nucleotide-binding protein subunit beta-2-like 1; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397605); (R-SSC-5357905); (R-SSC-5357956); (R-SSC-5626978); (R-SSC-9766229)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10673032;20976005;32247758;32543654;32605753", "class_list": "", "function": "Integrin beta3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-kappaB activation in Marc-145 cells., [RefSeq, PubMed]; Porcine RACK1 negatively regulates the infection of classical swine fever virus and the NF-kappaB activation in PK-15 cells., [RefSeq, PubMed]; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Regulates internalization of the muscarinic receptor CHRM2 (PubMed:20976005). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25388;P99049", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005080 protein kinase C binding;GO:0042169 SH2 domain binding;GO:0030971 receptor tyrosine kinase binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:1990630 IRE1-RACK1-PP2A complex;GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0001934 positive regulation of protein phosphorylation;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79387-1", "uniprot_id": "STF1_PIG", "mass": 51575.0, "length": 461, "protein_name": "Steroidogenic factor 1", "gene_name": "NR5A1", "organism": "Pig", "refseq_name": "steroidogenic factor 1", "refseq_ac": "NP_999344", "gene_names_uniprotkb": "NR5A1; FTZF1", "gene_names_refseq": "NR5A1; SF-1", "protein_names_uniprotkb": "Steroidogenic factor 1; Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; SF-1; STF-1; Steroid hormone receptor Ad4BP", "protein_names_refseq": "STF-1; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1; steroidogenic factor-1 SF-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397368); (R-SSC-383280); (R-SSC-4090294)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17416745;26055431;29378329;32543654;9724033", "class_list": "", "function": "Liver receptor homolog (LRH)-1, not CYP19A1, is a direct functional target of miR-1275., [RefSeq, PubMed]; NR5A1 variations influence meat color in a hypothalamus-pituitary-adrenal axis independent manner, [RefSeq, PubMed]; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BD07", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:2000020 positive regulation of male gonad development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02540-1", "uniprot_id": "DESM_PIG", "mass": 53629.0, "length": 471, "protein_name": "Desmin", "gene_name": "DES", "organism": "Pig", "refseq_name": "desmin", "refseq_ac": "NP_001001535", "gene_names_uniprotkb": "DES", "gene_names_refseq": "DES", "protein_names_uniprotkb": "Desmin", "protein_names_refseq": "desmin; muscle-specific intermediate filament desmin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396725); (R-SSC-390522)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "32543654;6945574", "class_list": "", "function": "Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O62656", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0045109 intermediate filament organization;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02540-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GKQ9-1", "uniprot_id": "SMAD4_PIG", "mass": 60415.0, "length": 552, "protein_name": "SMAD family member 4", "gene_name": "SMAD4", "organism": "Pig", "refseq_name": "SMAD family member 4", "refseq_ac": "NP_999237", "gene_names_uniprotkb": "SMAD4; MADH4", "gene_names_refseq": "MADH4; SMAD4", "protein_names_uniprotkb": "SMAD family member 4; MAD homolog 4; Mothers against DPP homolog 4; Mothers against decapentaplegic homolog 4; SMAD 4", "protein_names_refseq": "MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; SMAD 4; SMAD family member 4; mothers against DPP homolog 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:397142); (R-SSC-1181150); (R-SSC-1502540); (R-SSC-201451); (R-SSC-2173789); (R-SSC-2173795); (R-SSC-2173796); (R-SSC-5689880); (R-SSC-8941326); (R-SSC-8941855); (R-SSC-9617828)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "21292728;25395673;27882941;29396446;29723543;32543654;32899767", "class_list": "", "function": "Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; CYP19A1 is an inhibitor of follicular atresia and is regulated by both SMAD4 and miR-10b., [RefSeq, PubMed]; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity)., [UniProtKB]; MiR-361-5p Mediates SMAD4 to Promote Porcine Granulosa Cell Apoptosis through VEGFA. Publication Status: Online-Only, [RefSeq, PubMed]; MiR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression., [RefSeq, PubMed]; SMAD4, a core component of the canonical TGF-beta signaling pathway, regulates the canonical TGF-beta signaling pathway in porcine granulosa cells (GCs) through a feedback mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0032444 activin responsive factor complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0010631 epithelial cell migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9GKQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45561-1", "uniprot_id": "AMEL_PIG", "mass": 21387.0, "length": 189, "protein_name": "Amelogenin", "gene_name": "AMELX; AMEL", "organism": "Pig", "refseq_name": "amelogenin precursor", "refseq_ac": "NP_999071", "gene_names_uniprotkb": "AMELX; AMEL", "gene_names_refseq": "AMELX; AMEL; LRAP", "protein_names_uniprotkb": "Amelogenin; Amelogenin 173A/173B; LRAP; Leucine-rich amelogenin peptide", "protein_names_refseq": "amelogenin (amelogenesis imperfecta 1, X-linked); amelogenin 173A/173B; amelogenin 173A; amelogenin 173B; amelogenin precursor; leucine-rich amelogenin peptide", "tax_id": 9823, "disease": "", "pathway": " (ssc:396714); (ssc:396940); (R-SSC-381426); (R-SSC-8957275)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "21525716;21576914;27366858;27632699;32543654;8250931;8955667", "class_list": "", "function": "Differences in the viscoelastic properties of phosphorylated amelogenin (P173) and recombinant non-phosphorylated amelogenin (rP172) in the adsorbed state were observed, consistent with noted differences in hydroxyapatite (HAP) binding., [RefSeq, PubMed]; Molecular dynamics simulations of the intrinsically disordered protein amelogenin have been reported., [RefSeq, PubMed]; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel., [UniProtKB]; The N-terminal domain of amelogenin may play a direct role in early stages of enamel formation., [RefSeq, PubMed]; The present study provides novel insights into the possible cooperation between enamelin and amelogenin in macromolecular coassembly and in controlling enamel mineral formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0030345 structural constituent of tooth enamel", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0070166 enamel mineralization;GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P45561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6SEG5-1", "uniprot_id": "UCHL1_PIG", "mass": 24859.0, "length": 223, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L1", "gene_name": "UCHL1", "organism": "Pig", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L1", "refseq_ac": "NP_998928", "gene_names_uniprotkb": "UCHL1", "gene_names_refseq": "UCH-L1; UCHL1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L1; 3.4.19.12; UCH-L1; Ubiquitin thioesterase L1", "protein_names_refseq": "ubiquitin C-terminal hydrolase 1; ubiquitin carboxyl-terminal hydrolase L1; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; ubiquitin thiolesterase L1", "tax_id": 9823, "disease": "", "pathway": " (ssc:396637); (R-SSC-5689603)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19388011;26180514;32543654;37797697", "class_list": "", "function": "Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM., [RefSeq, PubMed]; Deubiquitinase UCHL1 regulates estradiol synthesis by stabilizing voltage-dependent anion channel 2., [RefSeq, PubMed]; The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0008242 omega peptidase activity;GO:0031625 ubiquitin protein ligase binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0071466 cellular response to xenobiotic stimulus;GO:0045821 positive regulation of glycolytic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6SEG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V620-1", "uniprot_id": "A0A4X1V620_PIG", "mass": 52452.0, "length": 469, "protein_name": "Flavin-containing monooxygenase", "gene_name": "FMO1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FMO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Flavin-containing monooxygenase; 1.-.-.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5S6H998", "ec_number_list": "", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity;GO:0047822 hypotaurine monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009404 toxin metabolic process;GO:0042412 taurine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V620-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q865B6-1", "uniprot_id": "PRGC1_PIG", "mass": 90336.0, "length": 796, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "gene_name": "PPARGC1A", "organism": "Pig", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "refseq_ac": "NP_999128", "gene_names_uniprotkb": "PPARGC1A; PGC1A; PGC1; PPARGC1", "gene_names_refseq": "PGC1A; PGC1; PPARGC-1; PPARGC1A; PPARGC1", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha", "protein_names_refseq": "PGC-1-alpha; PPAR gamma coactivator 1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; peroxisome proliferator activated receptor gamma coactivator 1; peroxisome proliferator activated receptor gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "tax_id": 9823, "disease": "", "pathway": " (ssc:397013); (R-SSC-9841922)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16276098;17149556;19875886;20412126;21748318;21769481;25004892;28644880;32543654;37057868", "class_list": "", "function": "Impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes, [RefSeq, PubMed]; MicroRNA-27a inhibits porcine type I muscle fibre gene expression by directly targeting peroxisome proliferator-activated receptor-gamma coactivator-1alpha., [RefSeq, PubMed]; PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition., [RefSeq, PubMed]; Proliferator-activated receptor-gamma coactivator-1A p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness(P < 0.01)., [RefSeq, PubMed]; Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes. Erratum:[PLoS One. 2017 Aug 15;12(8):e0183566. doi: 10.1371/journal.pone.0183566. PMID: 28809945] Publication Status: Online-Only, [RefSeq, PubMed]; The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality., [RefSeq, PubMed]; The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits., [RefSeq, PubMed]; The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits., [RefSeq, PubMed]; Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis., [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0031625 ubiquitin protein ligase binding;GO:0031490 chromatin DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q865B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VBQ3-1", "uniprot_id": "A0A4X1VBQ3_PIG", "mass": 76197.0, "length": 666, "protein_name": "Frizzled-3", "gene_name": "FZD3", "organism": "Pig", "refseq_name": "frizzled-3 isoform X1", "refseq_ac": "XP_001928822", "gene_names_uniprotkb": "FZD3", "gene_names_refseq": "FZD3", "protein_names_uniprotkb": "Frizzled-3", "protein_names_refseq": "frizzled-3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153078); (R-SSC-4086398); (R-SSC-4086400); (R-SSC-4608870)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZRQ0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0016055 Wnt signaling pathway;GO:0048513 animal organ development;GO:0009653 anatomical structure morphogenesis;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VBQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VEK1-1", "uniprot_id": "A0A4X1VEK1_PIG", "mass": 113824.0, "length": 975, "protein_name": "E3 ubiquitin protein ligase", "gene_name": "RNF20", "organism": "Pig", "refseq_name": "E3 ubiquitin-protein ligase BRE1A", "refseq_ac": "XP_001926629", "gene_names_uniprotkb": "RNF20", "gene_names_refseq": "RNF20", "protein_names_uniprotkb": "E3 ubiquitin protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase BRE1A", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154259); (R-SSC-8866654); (R-SSC-9013422)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SSB0;I3L5V4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0033503 HULC complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030336 negative regulation of cell migration;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VEK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MIZ3-1", "uniprot_id": "DCPS_PIG", "mass": 38581.0, "length": 337, "protein_name": "m7GpppX diphosphatase", "gene_name": "DCPS", "organism": "Pig", "refseq_name": "m7GpppX diphosphatase", "refseq_ac": "NP_998955", "gene_names_uniprotkb": "DCPS; DCS1; HINT5", "gene_names_refseq": "DCPS; HINT-5", "protein_names_uniprotkb": "m7GpppX diphosphatase; 3.6.1.59; DCS-1; Decapping scavenger enzyme; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; Scavenger mRNA-decapping enzyme DcpS", "protein_names_refseq": "DCS-1; decapping scavenger enzyme; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; m7GpppX diphosphatase; scavenger mRNA-decapping enzyme DcpS", "tax_id": 9823, "disease": "", "pathway": " (ssc:396689); (R-SSC-429958)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8MIZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VHC3-1", "uniprot_id": "A0A4X1VHC3_PIG", "mass": 42083.0, "length": 359, "protein_name": "Fucosyltransferase", "gene_name": "FUT9", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FUT9", "gene_names_refseq": "", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:102160171); (R-SSC-9037629)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RY05", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0010976 positive regulation of neuron projection development;GO:0006493 protein O-linked glycosylation;GO:0030182 neuron differentiation;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 1336, "hit_score": 0.2, "record_id": "A0A4X1VHC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VHH1-1", "uniprot_id": "A0A4X1VHH1_PIG", "mass": 116046.0, "length": 1003, "protein_name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5", "gene_name": "SMARCA5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMARCA5", "gene_names_refseq": "", "protein_names_uniprotkb": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5250924); (R-SSC-5693565); (R-SSC-606279)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZP73", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006334 nucleosome assembly;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VHH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VQA9-1", "uniprot_id": "A0A4X1VQA9_PIG", "mass": 48352.0, "length": 424, "protein_name": "Stress-activated protein kinase JNK", "gene_name": "MAPK9", "organism": "Pig", "refseq_name": "mitogen-activated protein kinase 9 isoform X2", "refseq_ac": "XP_005661498", "gene_names_uniprotkb": "MAPK9", "gene_names_refseq": "MAPK9", "protein_names_uniprotkb": "Stress-activated protein kinase JNK; 2.7.11.24", "protein_names_refseq": "mitogen-activated protein kinase 9 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2559580); (R-SSC-2871796); (R-SSC-450321); (R-SSC-450341)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A287APM5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0004705 JUN kinase activity;GO:0106310 protein serine kinase activity;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0098685 Schaffer collateral - CA1 synapse;GO:0005634 nucleus", "go_biological_process": "GO:0010744 positive regulation of macrophage derived foam cell differentiation;GO:0031398 positive regulation of protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VQA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2EN76-1", "uniprot_id": "NDKB_PIG", "mass": 17176.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME2", "organism": "Pig", "refseq_name": "nucleoside diphosphate kinase B", "refseq_ac": "NP_001038075", "gene_names_uniprotkb": "NME2", "gene_names_refseq": "NDPK B; NDPK2; NME2", "protein_names_uniprotkb": "Nucleoside diphosphate kinase B; 2.7.13.3; 2.7.4.6; Histidine protein kinase NDKB; NDP kinase B; NDPK B; NDPK2; Nucleoside diphosphate kinases 2", "protein_names_refseq": "NDK B; NDP kinase B; c-myc transcription factor; histidine protein kinase NDKB; nm23-H2; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleoside diphosphate kinases 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:733683); (R-SSC-499943); (R-SSC-6798695); (R-SSC-9748787); (R-SSC-9755088)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis. Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (By similarity). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (By similarity). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells. Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling. In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription. G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (By similarity). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (By similarity). Also negatively regulates Rho activity by interacting with AKAP13/LBC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0071944 cell periphery;GO:0001726 ruffle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007229 integrin-mediated signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2EN76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XSZ6-1", "uniprot_id": "FCERG_PIG", "mass": 9681.0, "length": 86, "protein_name": "High affinity immunoglobulin epsilon receptor subunit gamma", "gene_name": "FCER1G", "organism": "Pig", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit gamma precursor", "refseq_ac": "NP_001001265", "gene_names_uniprotkb": "FCER1G", "gene_names_refseq": "FCER1G", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit gamma; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FcRgamma; FceRI gamma; IgE Fc receptor subunit gamma", "protein_names_refseq": "Fc epsilon receptor gamma chain; Fc fragment of IgE receptor Ig; Fc receptor gamma-chain; associated with Fc gamma receptor III; fc-epsilon RI-gamma; fcRgamma; fceRI gamma; high affinity immunoglobulin epsilon receptor subunit gamma precursor; high affinity immunoglobulin epsilon receptor subunit gamma; igE Fc receptor subunit gamma", "tax_id": 9823, "disease": "", "pathway": " (ssc:397406)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production b basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0042803 protein homodimerization activity;GO:0019864 IgG binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex;GO:0033001 Fc-gamma receptor III complex", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0002554 serotonin secretion by platelet;GO:0010543 regulation of platelet activation;GO:0038156 interleukin-3-mediated signaling pathway;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XSZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26894-1", "uniprot_id": "IL8_PIG", "mass": 11633.0, "length": 103, "protein_name": "Interleukin-8", "gene_name": "CXCL8", "organism": "Pig", "refseq_name": "interleukin-8 precursor", "refseq_ac": "NP_999032", "gene_names_uniprotkb": "CXCL8; IL8", "gene_names_refseq": "AMCF-I; CXCL8; IL8", "protein_names_uniprotkb": "Interleukin-8; AMCF-I; Alveolar macrophage chemotactic factor I; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; IL-8", "protein_names_refseq": "C-X-C motif chemokine 8; IL-8; alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; chemokine (C-X-C motif) ligand 8; interleukin-8 precursor; interleukin-8", "tax_id": 9823, "disease": "", "pathway": " (ssc:396880); (R-SSC-375276); (R-SSC-380108); (R-SSC-418594)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "1420165;1850745;29521102;31831027;32543654;34935443;38675986;38791369;8276881", "class_list": "", "function": "CXCL8 Knockout: A Key to Resisting Pasteurella multocida Toxin-Induced Cytotoxicity. Publication Status: Online-Only, [RefSeq, PubMed]; Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PCV2 Induced Endothelial Derived IL-8 Affects MoDCs Maturation Mainly via NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Porcine circovirus type 2-induced endothelial IL-8 reduces the adhesion and migration ability of monocyte-derived dendritic cells, resulting in a decreased maturation rate of monocyte-derived dendritic cells, and further inhibits antigen presentation by dendritic cells. Publication Status: Online-Only, [RefSeq, PubMed]; The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-lambda., [RefSeq, PubMed]; This study evaluated the subcellular localization and other functions of TGEV nsp7 protein through analysis of its effects on cell growth, cell cycle progression, interleukin 8 (IL-8) expression, and NF-kappaB activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22951", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005153 interleukin-8 receptor binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0006954 inflammatory response;GO:0030155 regulation of cell adhesion;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P26894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29561-1", "uniprot_id": "KCY_PIG", "mass": 22279.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "CMPK1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CMPK1; CMPK; UCK", "gene_names_refseq": "", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-499943)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32543654;8586643", "class_list": "", "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QFF1-1", "uniprot_id": "A0A5G2QFF1_PIG", "mass": 149799.0, "length": 1337, "protein_name": "Vascular endothelial growth factor receptor 1", "gene_name": "FLT1", "organism": "Pig", "refseq_name": "vascular endothelial growth factor receptor 1 isoform X2", "refseq_ac": "XP_001925775", "gene_names_uniprotkb": "FLT1", "gene_names_refseq": "FLT1", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 1; 2.7.10.1; Fms-like tyrosine kinase 1; Tyrosine-protein kinase receptor FLT", "protein_names_refseq": "vascular endothelial growth factor receptor 1 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:396763); (R-SSC-194306); (R-SSC-195399)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0005021 vascular endothelial growth factor receptor activity;GO:0036332 placental growth factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QFF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O19064-1", "uniprot_id": "JAK2_PIG", "mass": 130759.0, "length": 1131, "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "organism": "Pig", "refseq_name": "tyrosine-protein kinase JAK2", "refseq_ac": "NP_999278", "gene_names_uniprotkb": "JAK2", "gene_names_refseq": "JAK2", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK2; 2.7.10.2; JAK-2; Janus kinase 2", "protein_names_refseq": "JAK-2; tyrosine-protein kinase JAK2", "tax_id": 9823, "disease": "", "pathway": " (ssc:397201); (R-SSC-1059683); (R-SSC-112411); (R-SSC-1170546); (R-SSC-1433557); (R-SSC-512988); (R-SSC-5673000); (R-SSC-5673001); (R-SSC-6785807); (R-SSC-6788467); (R-SSC-69231); (R-SSC-877300); (R-SSC-877312); (R-SSC-8854691); (R-SSC-8984722); (R-SSC-9006335); (R-SSC-9020591); (R-SSC-9020933); (R-SSC-9020956); (R-SSC-9027276); (R-SSC-9027284); (R-SSC-912526); (R-SSC-9674555); (R-SSC-9705462); (R-SSC-9732724); (R-SSC-982772); (R-SSC-983231); (R-SSC-9958825)", "pathway_count": 28, "publication_count": 2, "publication_id_list": "17510232;32543654", "class_list": "", "function": "Nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK-STAT-AKT interactions, [RefSeq, PubMed]; Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Functionnally, plays a pivotal role in signal transduction and is involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Up-regulates the potassium voltage-gated channel activity of KCNA3. Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3. Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0060399 positive regulation of growth hormone receptor signaling pathway;GO:0038043 interleukin-5-mediated signaling pathway;GO:0038156 interleukin-3-mediated signaling pathway;GO:0001774 microglial cell activation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O19064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62936-1", "uniprot_id": "PPIA_PIG", "mass": 17869.0, "length": 164, "protein_name": "Peptidyl-prolyl cis-trans isomerase A", "gene_name": "PPIA", "organism": "Pig", "refseq_name": "peptidyl-prolyl cis-trans isomerase A", "refseq_ac": "NP_999518", "gene_names_uniprotkb": "PPIA", "gene_names_refseq": "CYPA; PPIA", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase A; 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; PPIase A; Rotamase A", "protein_names_refseq": "PPIase A; cyclophilin A; cyclosporin A-binding protein; peptidyl-prolyl cis-trans isomerase A; rotamase A", "tax_id": 9823, "disease": "", "pathway": " (ssc:397637)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2492638;2644542;32543654;33809359;8672129", "class_list": "", "function": "Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P04374;P10110;Q29580;Q53ZT4", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:1904399 heparan sulfate binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08419-1", "uniprot_id": "CEL2A_PIG", "mass": 28699.0, "length": 269, "protein_name": "Chymotrypsin-like elastase family member 2A", "gene_name": "CELA2A", "organism": "Pig", "refseq_name": "chymotrypsin-like elastase family member 2A preproprotein", "refseq_ac": "NP_999274", "gene_names_uniprotkb": "CELA2A; ELA2A; ELA2", "gene_names_refseq": "CELA2A; ELA2; ELANE", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 2A; 3.4.21.71; Elastase-2A; Elastase-2", "protein_names_refseq": "chymotrypsin-like elastase family member 2A preproprotein; elastase 2, neutrophil; elastase-2A; elastase-2; pancreatic elastase II", "tax_id": 9823, "disease": "", "pathway": " (ssc:397197); (R-SSC-6809371)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2834346;32543654;3646943", "class_list": "", "function": "Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0050796 regulation of insulin secretion;GO:0032868 response to insulin;GO:1901143 insulin catabolic process;GO:0090330 regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14287-1", "uniprot_id": "OSTP_PIG", "mass": 33669.0, "length": 303, "protein_name": "Osteopontin", "gene_name": "SPP1", "organism": "Pig", "refseq_name": "osteopontin precursor", "refseq_ac": "NP_999188", "gene_names_uniprotkb": "SPP1; OPN", "gene_names_refseq": "Opn; SPP1", "protein_names_uniprotkb": "Osteopontin; Bone sialoprotein 1; SPP-1; Secreted phosphoprotein 1", "protein_names_refseq": "SPP-1; bone sialoprotein 1; osteopontin precursor; osteopontin; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397087); (R-SSC-1474228); (R-SSC-186797); (R-SSC-216083); (R-SSC-381426); (R-SSC-8957275)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "1633816;22391653;22974008;2332443;23575146;25101273;2602123;31990676;32543654", "class_list": "", "function": "Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity., [UniProtKB, UniProtKB]; Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction., [UniProtKB, UniProtKB]; Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM., [RefSeq, PubMed]; OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature., [RefSeq, PubMed]; Results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene, [RefSeq, PubMed]; The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0005125 cytokine activity;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005576 extracellular region", "go_biological_process": "GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0007155 cell adhesion;GO:0071394 cellular response to testosterone stimulus;GO:0045780 positive regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SQ34-1", "uniprot_id": "TNR5_PIG", "mass": 30951.0, "length": 278, "protein_name": "Tumor necrosis factor receptor superfamily member 5", "gene_name": "CD40", "organism": "Pig", "refseq_name": "tumor necrosis factor receptor superfamily member 5 precursor", "refseq_ac": "NP_999359", "gene_names_uniprotkb": "CD40; TNFRSF5", "gene_names_refseq": "CD40; TNFRSF5", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; CD40L receptor", "protein_names_refseq": "B-cell surface antigen CD40; CD40L receptor; tumor necrosis factor receptor superfamily member 5 precursor; tumor necrosis factor receptor superfamily member 5", "tax_id": 9823, "disease": "", "pathway": " (ssc:397395); (R-SSC-198933); (R-SSC-5668541); (R-SSC-5676594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16677604;17675236;19036453;32543654", "class_list": "", "function": "Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion., [UniProtKB, UniProtKB, UniProtKB]; The appearance of CD25 after activation of porcine dendritic cells, is reported., [RefSeq, PubMed]; These results therefore may help understand the molecular mechanism of CD40L signaling that contributes to the pathophysiology of atherosclerosis., [RefSeq, PubMed]; This study shows that xenogeneic interaction between hCD40L and pCD40 can activate porcine endothelial cells through NF-kappaB signaling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0035631 CD40 receptor complex", "go_biological_process": "GO:0023035 CD40 signaling pathway;GO:0006952 defense response;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SQ34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46427-1", "uniprot_id": "CATH_PIG", "mass": 37455.0, "length": 335, "protein_name": "Pro-cathepsin H", "gene_name": "CTSH", "organism": "Pig", "refseq_name": "pro-cathepsin H precursor", "refseq_ac": "NP_999094", "gene_names_uniprotkb": "CTSH", "gene_names_refseq": "CTSH", "protein_names_uniprotkb": "Pro-cathepsin H", "protein_names_refseq": "pro-cathepsin H precursor; pro-cathepsin H", "tax_id": 9823, "disease": "", "pathway": " (ssc:396969); (R-SSC-2132295); (R-SSC-5683826); (R-SSC-6798695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "32543654;9493267", "class_list": "", "function": "Important for the overall degradation of proteins in lysosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0070324 thyroid hormone binding;GO:0004177 aminopeptidase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome;GO:0097208 alveolar lamellar body", "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O46427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2QLE0-1", "uniprot_id": "MET_PIG", "mass": 154748.0, "length": 1381, "protein_name": "Hepatocyte growth factor receptor", "gene_name": "MET", "organism": "Pig", "refseq_name": "hepatocyte growth factor receptor precursor", "refseq_ac": "NP_001033097", "gene_names_uniprotkb": "MET", "gene_names_refseq": "MET", "protein_names_uniprotkb": "Hepatocyte growth factor receptor; 2.7.10.1; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; SF receptor; Scatter factor receptor; Tyrosine-protein kinase Met", "protein_names_refseq": "HGF receptor; HGF/SF receptor; SF receptor; hepatocyte growth factor receptor precursor; hepatocyte growth factor receptor; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met", "tax_id": 9823, "disease": "", "pathway": " (ssc:654328); (R-SSC-1257604); (R-SSC-416550); (R-SSC-5673001); (R-SSC-6806942); (R-SSC-6807004); (R-SSC-6811558); (R-SSC-8851805); (R-SSC-8851907); (R-SSC-8865999); (R-SSC-8874081); (R-SSC-8875513); (R-SSC-8875555); (R-SSC-8875656); (R-SSC-8875791); (R-SSC-9734091)", "pathway_count": 16, "publication_count": 2, "publication_id_list": "12917688;32543654", "class_list": "", "function": "Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells (By similarity)., [UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 11, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q2VHX7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding;GO:0017154 semaphorin receptor activity;GO:0005008 hepatocyte growth factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001889 liver development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2QLE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19100-1", "uniprot_id": "CP17A_PIG", "mass": 57447.0, "length": 509, "protein_name": "Steroid 17-alpha-hydroxylase/17,20 lyase", "gene_name": "CYP17A1", "organism": "Pig", "refseq_name": "steroid 17-alpha-hydroxylase/17,20 lyase", "refseq_ac": "NP_999593", "gene_names_uniprotkb": "CYP17A1; CYP17", "gene_names_refseq": "CYP17A1; CYP17; P450c17", "protein_names_uniprotkb": "Steroid 17-alpha-hydroxylase/17,20 lyase; 1.14.14.19; 1.14.14.32; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase", "protein_names_refseq": "17-alpha-hydroxylase cytochrome P450; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; cytochrome P450 17A1; cytochrome P450-C17; cytochrome P450c17; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase", "tax_id": 9823, "disease": "", "pathway": " (ssc:403330); (R-SSC-193048); (R-SSC-194002)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1543750;1627653;16341769;16595705;19101629;21804630;3025870;32543654", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone, [RefSeq, PubMed]; Synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene., [RefSeq, PubMed]; The immunolocalization of P450c17, detected in the ovaries of pregnant pigs and fetal porcine gonads, indicates the potential sites of androgen synthesis., [RefSeq, PubMed]; These results demonstrate the differential effects of two forms of CYB5 on the three activities of porcine CYP17A1 and show that CYB5B does not stimulate the andien-beta synthase activity of CYP17A1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29553;Q99030", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0004508 steroid 17-alpha-monooxygenase activity", "go_cellular_component": "GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042446 hormone biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0008202 steroid metabolic process;GO:0042448 progesterone metabolic process;GO:0034651 cortisol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q684M4-1", "uniprot_id": "KEAP1_PIG", "mass": 69816.0, "length": 624, "protein_name": "Kelch-like ECH-associated protein 1", "gene_name": "KEAP1", "organism": "Pig", "refseq_name": "kelch-like ECH-associated protein 1", "refseq_ac": "NP_001108143", "gene_names_uniprotkb": "KEAP1", "gene_names_refseq": "INRF2; KEAP1", "protein_names_uniprotkb": "Kelch-like ECH-associated protein 1", "protein_names_refseq": "cytosolic inhibitor of Nrf2; kelch-like ECH-associated protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100136900); (R-SSC-5689880); (R-SSC-8951664); (R-SSC-9755511)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15305063;32543654", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0097718 disordered domain specific binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010506 regulation of autophagy;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034599 cellular response to oxidative stress;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q684M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77633-1", "uniprot_id": "ADA10_PIG", "mass": 84383.0, "length": 748, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "organism": "Pig", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 10 precursor", "refseq_ac": "NP_001124003", "gene_names_uniprotkb": "ADAM10", "gene_names_refseq": "ADAM-10; ADAM10", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 10; 3.4.24.81; ADAM 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease", "protein_names_refseq": "ADAM 10; a disintegrin and metalloproteinase domain-containing protein 10; disintegrin and metalloproteinase domain-containing protein 10 precursor; disintegrin and metalloproteinase domain-containing protein 10; disintegrin-metalloproteinase; kuzbanian protein homolog; mammalian disintegrin-metalloprotease", "tax_id": 9823, "disease": "", "pathway": " (ssc:397345); (R-SSC-1474228); (R-SSC-381426); (R-SSC-6798695); (R-SSC-8957275)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10429942;11230111;24386293;32543654", "class_list": "", "function": "Significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (By similarity). Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B3VKE8;K7GKL8", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006509 membrane protein ectodomain proteolysis;GO:0007162 negative regulation of cell adhesion;GO:0007219 Notch signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O77633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18430-1", "uniprot_id": "IL1A_PIG", "mass": 30789.0, "length": 270, "protein_name": "Interleukin-1 alpha", "gene_name": "IL1A", "organism": "Pig", "refseq_name": "interleukin-1 alpha precursor", "refseq_ac": "NP_999194", "gene_names_uniprotkb": "IL1A", "gene_names_refseq": "IL-1alpha; IL1A", "protein_names_uniprotkb": "Interleukin-1 alpha; IL-1 alpha", "protein_names_refseq": "IL-1 alpha; interleukin-1 alpha precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397094); (R-SSC-448706); (R-SSC-5620971); (R-SSC-9020702)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18292602;2377484;32543654;33758095", "class_list": "", "function": "Constitutive suppression of IL-1alpha maintains quiescence of endothelium and that terminal complement complexes remove that suppression, allowing IL-1alpha transcription and, ultimately, activation of endothelium to proceed., [RefSeq, PubMed]; Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity., [UniProtKB, UniProtKB]; Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005507 copper ion binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005576 extracellular region", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9MYZ9-1", "uniprot_id": "EPOR_PIG", "mass": 55184.0, "length": 509, "protein_name": "Erythropoietin receptor", "gene_name": "EPOR", "organism": "Pig", "refseq_name": "erythropoietin receptor precursor", "refseq_ac": "NP_999457", "gene_names_uniprotkb": "EPOR", "gene_names_refseq": "EPOR", "protein_names_uniprotkb": "Erythropoietin receptor; EPO-R", "protein_names_refseq": "EPO-R; erythropoietin receptor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397554); (R-SSC-9006335); (R-SSC-9027276); (R-SSC-9027284)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10962196;32543654", "class_list": "", "function": "Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (By similarity). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (By similarity). May also activate the LYN tyrosine kinase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004900 erythropoietin receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0038162 erythropoietin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9MYZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLF3-1", "uniprot_id": "CLC5A_PIG", "mass": 20835.0, "length": 185, "protein_name": "C-type lectin domain family 5 member A", "gene_name": "CLEC5A", "organism": "Pig", "refseq_name": "C-type lectin domain family 5 member A", "refseq_ac": "NP_999155", "gene_names_uniprotkb": "CLEC5A; CLECSF5; MDL1", "gene_names_refseq": "CLEC5A; CLECSF5", "protein_names_uniprotkb": "C-type lectin domain family 5 member A; C-type lectin superfamily member 5; MDL-1; Myeloid DAP12-associating lectin 1", "protein_names_refseq": "C-type lectin domain family 5 member A; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1; myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin long form", "tax_id": 9823, "disease": "", "pathway": " (ssc:397050); (R-SSC-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11414735;32543654", "class_list": "", "function": "Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:11414735). Regulates inflammatory responses (By similarity)., [UniProtKB, UniProtKB, PubMed]; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9GLF4", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0002076 osteoblast development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9GLF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29554-1", "uniprot_id": "ECHA_PIG", "mass": 83107.0, "length": 763, "protein_name": "Trifunctional enzyme subunit alpha, mitochondrial", "gene_name": "HADHA", "organism": "Pig", "refseq_name": "trifunctional enzyme subunit alpha, mitochondrial", "refseq_ac": "NP_999127", "gene_names_uniprotkb": "HADHA; LCHYD-HAD", "gene_names_refseq": "HADHA; MLCL AT", "protein_names_uniprotkb": "Trifunctional enzyme subunit alpha, mitochondrial; 2.3.1.-; 78 kDa gastrin-binding protein; MLCL AT; Monolysocardiolipin acyltransferase; TP-alpha", "protein_names_refseq": "78 kDa gastrin-binding protein; TP-alpha; gastrin-binding protein; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; monolysocardiolipin acyltransferase; trifunctional enzyme subunit alpha, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:397012); (R-SSC-1482798); (R-SSC-77285); (R-SSC-77305); (R-SSC-77310); (R-SSC-77346); (R-SSC-77348); (R-SSC-77350)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "32543654;7881821;8297352;8399347;8512557", "class_list": "", "function": "Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each beta-oxidation cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). These cycles repeat until the chain is fully degraded to acetyl-CoA units. Among the enzymes involved in this pathway, the trifunctional protein--responsible for the hydration, dehydrogenation, and thiolysis steps, shows specificity for long-chain fatty acids, such as those from dietary and stored fats. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. These activities have been experimentally confirmed on a few substrates derived from beta-oxidation of long-chain saturated fatty acids such as palmitate (hexadecanoate) and laurate (dodecanoate). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on other substrates, including long-chain unsaturated fatty acids such as oleate (9Z-octadecenoate), linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid. HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin. Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0016740 transferase activity;GO:0070403 NAD+ binding;GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0035965 cardiolipin acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q29554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16582-1", "uniprot_id": "LSHR_PIG", "mass": 78092.0, "length": 696, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "LHCGR", "organism": "Pig", "refseq_name": "lutropin-choriogonadotropic hormone receptor precursor", "refseq_ac": "NP_999614", "gene_names_uniprotkb": "LHCGR", "gene_names_refseq": "LHCGR; LHR", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor", "protein_names_refseq": "LH/CG-R; LSH-R; lutropin-choriogonadotropic hormone receptor precursor; lutropin-choriogonadotropic hormone receptor; lutropin-choriogonadotropin receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:407247); (R-SSC-375281)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12816543;2502844;32543654", "class_list": "", "function": "In porcine ovaries, MAb found 6 distinct LHR bands migrating at approximately 92, 80, 68, 59, 52 & 48 kDa. There is a possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders & Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity;GO:0035472 choriogonadotropin hormone receptor activity;GO:0038106 choriogonadotropin hormone binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0008584 male gonad development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97716-1", "uniprot_id": "THA_PIG", "mass": 56265.0, "length": 506, "protein_name": "Thyroid hormone receptor alpha", "gene_name": "THRA", "organism": "Pig", "refseq_name": "thyroid hormone receptor alpha", "refseq_ac": "NP_999355", "gene_names_uniprotkb": "THRA; NR1A1", "gene_names_refseq": "C-ERBA-ALPHA; NR1A1; THRA", "protein_names_uniprotkb": "Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; c-erbA-1; c-erbA-alpha", "protein_names_refseq": "c-erbA-1; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha 2; thyroid hormone receptor alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397387); (R-SSC-383280); (R-SSC-4090294)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21751158;28972010;32543654", "class_list": "", "function": "Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine., [UniProtKB]; The TR-KLF9 axis is responsible for the hematopoietic dysfunction in congenital hypothyroidism, [RefSeq, PubMed]; There is considerable evidence that TRalpha plays an important role in fat deposition in porcine adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97715", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070324 thyroid hormone binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O97716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35463-1", "uniprot_id": "EDNRB_PIG", "mass": 49595.0, "length": 443, "protein_name": "Endothelin receptor type B", "gene_name": "EDNRB", "organism": "Pig", "refseq_name": "endothelin receptor type B precursor", "refseq_ac": "NP_001033091", "gene_names_uniprotkb": "EDNRB", "gene_names_refseq": "EDNRB; ETB", "protein_names_uniprotkb": "Endothelin receptor type B; ET-BR; ET-B; Endothelin receptor non-selective type", "protein_names_refseq": "ET-BR; ET-B; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor subtype B; endothelin receptor type B precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:414911); (R-SSC-375276); (R-SSC-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1312214;15240868;16441305;16709643;18278064;21726419;22460263;24414253;32543654;38166718", "class_list": "", "function": "Dual endothelin receptor blockade with tezosentan attenuates hypoxia-induced pulmonary vasoconstriction in porcine model., [RefSeq, PubMed]; ET(A)/ET(B) blockade decreased pulmonary vascular resistance but only during exercise., [RefSeq, PubMed]; Endothelin B receptors are involved in bladder relaxation via cAMP-PKA pathway-dependent-mechanisms, and involving BK(Ca) and SK(Ca) channel activation., [RefSeq, PubMed]; Extracellular ET-1 regulates the abundance of ET-1 mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK and p38 MAPK pathways, [RefSeq, PubMed]; Genome-wide detection of selection signatures in Jianli pigs reveals novel cis-regulatory haplotype in EDNRB associated with two-end black coat color. Publication Status: Online-Only, [RefSeq, PubMed]; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; PDE5 inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 inhibition., [RefSeq, PubMed]; Results suggest that endothelin A and B receptor protein and mRNA expression is developmentally regulated in the postnatal swine mesenteric artery., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2WG87", "ec_number_list": "", "go_molecular_function": "GO:0004962 endothelin receptor activity;GO:0017046 peptide hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0014043 negative regulation of neuron maturation;GO:0035645 enteric smooth muscle cell differentiation;GO:0048484 enteric nervous system development;GO:0086100 endothelin receptor signaling pathway;GO:1904383 response to sodium phosphate", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TV69-1", "uniprot_id": "DHDH_PIG", "mass": 36527.0, "length": 335, "protein_name": "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase", "gene_name": "DHDH", "organism": "Pig", "refseq_name": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase", "refseq_ac": "NP_999331", "gene_names_uniprotkb": "DHDH; 2DD", "gene_names_refseq": "2DD; DHDH; SUS2DD", "protein_names_uniprotkb": "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 1.1.1.-; 1.1.1.115; 1.1.1.119; 1.1.1.120; 1.1.1.179; 1.3.1.20; D-arabinose 1-dehydrogenase; D-galactose 1-dehydrogenase; D-glucose 1-dehydrogenase; D-ribose 1-dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase; Sus2DD", "protein_names_refseq": "D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; dimeric dihydrodiol dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397337)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10477285;11306093;2018468;28053104;32543654", "class_list": "", "function": "Catalyzes the NADP(+)-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols (PubMed:11306093, PubMed:2018468). It also catalyzes the oxidation of several pentoses and hexoses (PubMed:11306093). In the reverse reaction in the presence of NADPH, it acts as NADPH-linked reductase on a broad range of substrates including aldehydes, chetones, and alpha-dicarbonyl compounds such as 3-deoxyglucosone, camphorquinone and methylglyoxal (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001836 release of cytochrome c from mitochondria;GO:0033554 cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9TV69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TU45-1", "uniprot_id": "TYOBP_PIG", "mass": 11617.0, "length": 108, "protein_name": "TYRO protein tyrosine kinase-binding protein", "gene_name": "TYROBP", "organism": "Pig", "refseq_name": "TYRO protein tyrosine kinase-binding protein precursor", "refseq_ac": "NP_999367", "gene_names_uniprotkb": "TYROBP; DAP12", "gene_names_refseq": "DAP12; TYROBP", "protein_names_uniprotkb": "TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12", "protein_names_refseq": "DNAX-activation protein 12; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein precursor; immunoreceptor DAP12", "tax_id": 9823, "disease": "", "pathway": " (ssc:397405)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10866110;32543654", "class_list": "", "function": "Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001206 positive regulation of osteoclast development;GO:0032693 negative regulation of interleukin-10 production;GO:0002228 natural killer cell mediated immunity;GO:0002283 neutrophil activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9TU45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62807-1", "uniprot_id": "PPARG_PIG", "mass": 57512.0, "length": 504, "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "organism": "Pig", "refseq_name": "peroxisome proliferator-activated receptor gamma", "refseq_ac": "NP_999544", "gene_names_uniprotkb": "PPARG; NR1C3", "gene_names_refseq": "NR1C3; PPARG", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; PPAR-gamma", "protein_names_refseq": "PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activatived receptor gamma; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated receptor gamma 2; peroxisome proliferator-activated receptor gamma", "tax_id": 9823, "disease": "", "pathway": " (ssc:397671)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10481259;28677792;28882569;29550794;30656515;30772521;32543654;9731203;9931452", "class_list": "", "function": "Functionally distinct alleles of the PPARG gene are positioned in different parts of the cell nucleus. This confirms the importance of nuclear architecture to the regulation of PPARG gene transcription, and thus to the fate of the adipose cell., [RefSeq, PubMed]; Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids. Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites. Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression. Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuclear receptor that acts as the key factor controlling the development of adipocytes. Specifically activated by 15-deoxy-delta12,14-prostaglandin J2 ligand during early adipogenesis, driving differentiation of all types of adipocytes (white, beige and brown). Acts together with retinoic acid receptor RXRA, forming the ARF6 complex, which acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Following recruitment of TLE3, promotes differentiation of white adipocytes. Following recruitment of PRDM16, promotes differentiation of myoblastic precursors into brown adipose cells (BAT), which are specialized in dissipating energy in the form of heat in response to cold or excess feeding. Also mediates diffentiation of white adipocytes into beige adipocytes by mediating recruitment of PRDM16., [UniProtKB, UniProtKB]; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression., [RefSeq, PubMed]; Study demonstrated that overexpression of DNMT3A promoted the expression of cell proliferation markers but significantly decreased the expression of p21 to repress cell proliferation by the methylation of p21 promoter. Moreover, overexpression of DNMT3A decreased lipid accumulation and significantly down-regulated the levels of adipogenic marker genes through the methylation of PPARg promoter., [RefSeq, PubMed]; The results of the present study suggested that PPARG may mediate porcine placental angiogenesis, by interfering with hypoxia inducible factor, vascular endothelial growth factor and angiopoietinmediated signaling., [RefSeq, PubMed]; The results suggest the higher expression of miR-130a, which targeting peroxisome proliferator-activated receptor gamma, may be the reason for less fat deposition in intramuscular adipose tissue than subcutaneous adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77815;Q6L9M2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032385 positive regulation of intracellular cholesterol transport;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O62807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q767L6-1", "uniprot_id": "FLOT1_PIG", "mass": 47355.0, "length": 427, "protein_name": "Flotillin-1", "gene_name": "FLOT1", "organism": "Pig", "refseq_name": "flotillin-1", "refseq_ac": "NP_001121955", "gene_names_uniprotkb": "FLOT1", "gene_names_refseq": "FLOT1", "protein_names_uniprotkb": "Flotillin-1", "protein_names_refseq": "flotillin-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100151746); (R-SSC-5213460); (R-SSC-5675482); (R-SSC-8849932); (R-SSC-8980692); (R-SSC-9013026); (R-SSC-9013106)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "14673549;32543654", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0022617 extracellular matrix disassembly;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0032226 positive regulation of synaptic transmission, dopaminergic", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q767L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7YS99-1", "uniprot_id": "OPTN_PIG", "mass": 65703.0, "length": 574, "protein_name": "Optineurin", "gene_name": "OPTN", "organism": "Pig", "refseq_name": "optineurin", "refseq_ac": "NP_999126", "gene_names_uniprotkb": "OPTN", "gene_names_refseq": "OPTN", "protein_names_uniprotkb": "Optineurin", "protein_names_refseq": "optineurin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397011); (R-SSC-2565942); (R-SSC-5205685); (R-SSC-5357905); (R-SSC-5357956); (R-SSC-8854214); (R-SSC-936964); (R-SSC-9824878)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "11834836;15277488;32543654", "class_list": "", "function": "May act by regulating membrane trafficking and cellular morphogenesis., [UniProtKB, UniProtKB, UniProtKB]; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0043001 Golgi to plasma membrane protein transport;GO:0001920 negative regulation of receptor recycling;GO:0090161 Golgi ribbon formation;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7YS99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5H7C0-1", "uniprot_id": "CDC20_PIG", "mass": 54784.0, "length": 499, "protein_name": "Cell division cycle protein 20 homolog", "gene_name": "CDC20", "organism": "Pig", "refseq_name": "cell division cycle protein 20 homolog", "refseq_ac": "NP_001116566", "gene_names_uniprotkb": "CDC20", "gene_names_refseq": "CDC20", "protein_names_uniprotkb": "Cell division cycle protein 20 homolog; p55CDC", "protein_names_refseq": "cell division cycle 20 homolog; cell division cycle protein 20 homolog; p55CDC", "tax_id": 9823, "disease": "", "pathway": " (ssc:397379); (R-SSC-141405); (R-SSC-141430); (R-SSC-141444); (R-SSC-174048); (R-SSC-174154); (R-SSC-174178); (R-SSC-174184); (R-SSC-176407); (R-SSC-176408); (R-SSC-176409); (R-SSC-176417); (R-SSC-179409); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-5663220); (R-SSC-5689880); (R-SSC-68877); (R-SSC-9648025); (R-SSC-983168)", "pathway_count": 20, "publication_count": 2, "publication_id_list": "18753608;32543654", "class_list": "", "function": "Porcine FZR1 and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1, [RefSeq, PubMed]; Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (By similarity). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (By similarity). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (By similarity). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (By similarity). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0031915 positive regulation of synaptic plasticity;GO:0090129 positive regulation of synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5H7C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TRC7-1", "uniprot_id": "AOC1_PIG", "mass": 85475.0, "length": 755, "protein_name": "Diamine oxidase [copper-containing]", "gene_name": "AOC1", "organism": "Pig", "refseq_name": "diamine oxidase [copper-containing] precursor", "refseq_ac": "XP_003134601", "gene_names_uniprotkb": "AOC1; ABP; DAO", "gene_names_refseq": "ABP1; AOC1; DAO", "protein_names_uniprotkb": "Diamine oxidase [copper-containing]; 1.4.3.22; Amiloride-binding protein; Amine oxidase copper domain-containing protein 1; Diamine oxidase; Histaminase", "protein_names_refseq": "Amiloride-binding protein 1; Amiloride-sensitive amine oxidase; Amine oxidase copper domain-containing protein 1; Diamine oxidase; Histaminase; amiloride binding protein 1 (amine oxidase (copper-containing)); diamine oxidase [copper-containing] precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517436)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10782293;1457410;32543654;8144586;8672129", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:1457410, PubMed:8144586). Its preferred substrates in vitro are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses (By similarity). Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism (PubMed:8144586). It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 32, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "F1SSL3;Q29317", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070062 extracellular exosome", "go_biological_process": "GO:0009445 putrescine metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q9TRC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70BM6-1", "uniprot_id": "S22A8_PIG", "mass": 59387.0, "length": 543, "protein_name": "Organic anion transporter 3", "gene_name": "SLC22A8", "organism": "Pig", "refseq_name": "organic anion transporter 3", "refseq_ac": "NP_999620", "gene_names_uniprotkb": "SLC22A8; OAT3", "gene_names_refseq": "OAT3; SLC22A8", "protein_names_uniprotkb": "Organic anion transporter 3; Organic anion/dicarboxylate exchanger; Solute carrier family 22 member 8; pOAT3", "protein_names_refseq": "organic anion transporter 3; organic anion/dicarboxylate exchanger; pOAT3; renal organic anion transporter 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:407774); (R-SSC-561048)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15820748;32543654", "class_list": "", "function": "Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (By similarity). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (Probable). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:15820748). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0009636 response to toxic substance;GO:0015711 organic anion transport;GO:0015732 prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q70BM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4LE85-1", "uniprot_id": "RB27A_PIG", "mass": 24889.0, "length": 221, "protein_name": "Ras-related protein Rab-27A", "gene_name": "RAB27A", "organism": "Pig", "refseq_name": "ras-related protein Rab-27A", "refseq_ac": "NP_001027528", "gene_names_uniprotkb": "RAB27A", "gene_names_refseq": "RAB27A", "protein_names_uniprotkb": "Ras-related protein Rab-27A; 3.6.5.2", "protein_names_refseq": "member RAS oncogene family, RAB27A; ras-related protein Rab-27A", "tax_id": 9823, "disease": "", "pathway": " (ssc:606749); (R-SSC-6798695); (R-SSC-8876198); (R-SSC-9824585)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "16441305;32543654;33223235", "class_list": "", "function": "Foot-and-mouth disease virus degrades Rab27a to suppress the exosome-mediated antiviral immune response., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0030425 dendrite;GO:0005764 lysosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:1990182 exosomal secretion;GO:1903307 positive regulation of regulated secretory pathway;GO:0010628 positive regulation of gene expression;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4LE85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4GWZ2-1", "uniprot_id": "RSSA_PIG", "mass": 32928.0, "length": 295, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "RPSA", "organism": "Pig", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": "NP_001032223", "gene_names_uniprotkb": "RPSA; LAMR1", "gene_names_refseq": "LAMR1; RPSA", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40", "protein_names_refseq": "37 kDa laminin receptor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; lamR; laminin receptor 1; laminin-binding protein precursor p40; small ribosomal subunit protein uS2", "tax_id": 9823, "disease": "", "pathway": " (ssc:641351); (R-SSC-156827); (R-SSC-1799339); (R-SSC-72649); (R-SSC-72689); (R-SSC-72695); (R-SSC-72702); (R-SSC-72706); (R-SSC-975956); (R-SSC-975957); (R-SSC-9954714); (R-SSC-9954716)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "15790424;17434268;25694590;32543654", "class_list": "", "function": "Dengue virus serotypes 1, 2 and 3 all interact with the 37 kDa/67 kDa laminin receptor (LAMR1), a common non-integrin surface protein on many cell types. Publication Status: Online-Only, [RefSeq, PubMed]; Isolated a ribosomal protein SA cDNA that consists of 1064 bp with an open reading frame of 885 bp encoding a 295 aa protein, [RefSeq, PubMed]; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA., [UniProtKB, HAMAP, UniProtKB, PubMed]; These results indicate that LamR is a cellular attachment receptor for classical Swine Fever virus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0001618 virus receptor activity;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4GWZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09889-1", "uniprot_id": "PPA5_PIG", "mass": 38012.0, "length": 340, "protein_name": "Tartrate-resistant acid phosphatase type 5", "gene_name": "ACP5", "organism": "Pig", "refseq_name": "tartrate-resistant acid phosphatase type 5 precursor", "refseq_ac": "NP_999374", "gene_names_uniprotkb": "ACP5", "gene_names_refseq": "ACP5; TR-AP; TRAP; UF", "protein_names_uniprotkb": "Tartrate-resistant acid phosphatase type 5; 3.1.3.2; TR-AP; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase; UF; Uteroferrin", "protein_names_refseq": "acid phosphatase type 5; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase type 5 precursor; trATPase; type 5 acid phosphatase; uteroferrin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397414)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10425678;11098218;15519293;20433174;2598770;2969454;32543654;3579955;7587387;8463220", "class_list": "", "function": "Characterization and proteolytic analysis of uteroferrin, [RefSeq, PubMed]; The effect of metal ion substitution on the mechanism of catalysis, [RefSeq, PubMed]; Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P09889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25117-1", "uniprot_id": "CALCR_PIG", "mass": 57155.0, "length": 498, "protein_name": "Calcitonin receptor", "gene_name": "CALCR", "organism": "Pig", "refseq_name": "calcitonin receptor precursor", "refseq_ac": "NP_999519", "gene_names_uniprotkb": "CALCR", "gene_names_refseq": "CALCR; CTR", "protein_names_uniprotkb": "Calcitonin receptor; CT-R", "protein_names_refseq": "CT-R; calcitonin receptor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397638)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1658940;19696365;32543654;8034723", "class_list": "", "function": "G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0004948 calcitonin receptor activity;GO:0032841 calcitonin binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0097643 amylin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0001669 acrosomal vesicle;GO:0150058 amylin receptor complex 3;GO:0150056 amylin receptor complex 1", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25117-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97763-1", "uniprot_id": "NPC2_PIG", "mass": 16288.0, "length": 149, "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "organism": "Pig", "refseq_name": "NPC intracellular cholesterol transporter 2 precursor", "refseq_ac": "NP_999371", "gene_names_uniprotkb": "NPC2", "gene_names_refseq": "NPC2", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; 16 kDa secretory protein; Epididymal secretory protein E1; Niemann Pick type C2 protein homolog", "protein_names_refseq": "16 kDa secretory protein; 16kDa secretory protein; NPC intracellular cholesterol transporter 2 precursor; epididymal secretory protein E1; niemann Pick type C2 protein homolog", "tax_id": 9823, "disease": "", "pathway": " (ssc:397410); (R-SSC-6798695); (R-SSC-8964038)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10366780;32543654", "class_list": "", "function": "Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes (By similarity). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:10366780). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0019899 enzyme binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005770 late endosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0032367 intracellular cholesterol transport;GO:0033344 cholesterol efflux;GO:0030301 cholesterol transport;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O97763-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MIR4-1", "uniprot_id": "COASY_PIG", "mass": 61749.0, "length": 562, "protein_name": "Bifunctional coenzyme A synthase", "gene_name": "COASY", "organism": "Pig", "refseq_name": "bifunctional coenzyme A synthase precursor", "refseq_ac": "NP_998954", "gene_names_uniprotkb": "COASY", "gene_names_refseq": "COASY; PPAT/DPCK", "protein_names_uniprotkb": "Bifunctional coenzyme A synthase; CoA synthase; DPCOAK; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; NBP; POV-2; PPAT; Pantetheine-phosphate adenylyltransferase", "protein_names_refseq": "NBP; POV-2; bifunctional coenzyme A synthase precursor; bifunctional coenzyme A synthase; bifunctional phosphopantetheine adenylyl transferase / dephospho CoA kinase; coA synthase", "tax_id": 9823, "disease": "", "pathway": " (ssc:396688)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11994049;32543654;6312972", "class_list": "", "function": "Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'-phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0004595 pantetheine-phosphate adenylyltransferase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MIR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28944-1", "uniprot_id": "CATL1_PIG", "mass": 37178.0, "length": 334, "protein_name": "Procathepsin L", "gene_name": "CTSL; CTSV", "organism": "Pig", "refseq_name": "procathepsin L precursor", "refseq_ac": "NP_999057", "gene_names_uniprotkb": "CTSL; CTSV; CTSL1", "gene_names_refseq": "CTSL1; CTSL2; CTSL; CTSV", "protein_names_uniprotkb": "Procathepsin L; 3.4.22.15; Cathepsin L1", "protein_names_refseq": "cathepsin L1; cathepsin L; procathepsin L precursor; procathepsin L", "tax_id": 9823, "disease": "", "pathway": " (ssc:396926); (R-SSC-1592389); (R-SSC-1679131); (R-SSC-2132295); (R-SSC-8939242)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "11978977;20107207;20374908;25108379;32543654;7492581", "class_list": "", "function": "CTSL1 is expressed by endometrial epithelia, placental areolae, and neonatal intestine, and it may function in the transport of macromolecules across these epithelia., [RefSeq, PubMed]; Endosomal acidification and cathepsin L activity is required for porcine enteric calicivirus replication., [RefSeq, PubMed]; These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs., [RefSeq, PubMed]; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0016324 apical plasma membrane;GO:0042583 chromaffin granule", "go_biological_process": "GO:0016540 protein autoprocessing;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0031638 zymogen activation;GO:0034230 enkephalin processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q28944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2XVP4-1", "uniprot_id": "TBA1B_PIG", "mass": 50152.0, "length": 451, "protein_name": "Tubulin alpha-1B chain", "gene_name": "TUBA1B", "organism": "Pig", "refseq_name": "tubulin alpha-1B chain", "refseq_ac": "NP_001038009", "gene_names_uniprotkb": "TUBA1B", "gene_names_refseq": "TUBA1B; TUBA3", "protein_names_uniprotkb": "Tubulin alpha-1B chain; 3.6.5.-; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain", "protein_names_refseq": "alpha-tubulin ubiquitous; tubulin K-alpha-1; tubulin alpha 3; tubulin alpha-1B chain; tubulin alpha-ubiquitous chain", "tax_id": 9823, "disease": "", "pathway": " (ssc:733594); (R-SSC-190840); (R-SSC-2132295); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-3371497); (R-SSC-380320); (R-SSC-5610787); (R-SSC-5620920); (R-SSC-5620924); (R-SSC-5626467); (R-SSC-5663220); (R-SSC-6807878); (R-SSC-6811434); (R-SSC-68877); (R-SSC-8852276); (R-SSC-8955332); (R-SSC-9013407); (R-SSC-9646399); (R-SSC-9648025); (R-SSC-9668328); (R-SSC-983189); (R-SSC-9833482)", "pathway_count": 23, "publication_count": 6, "publication_id_list": "16441306;20043318;24227885;27452403;32543654;7225365", "class_list": "", "function": "Binding to the outside surface of the microtubule could facilitate access of tubulin acetyltransferase to its luminal site of action if microtubules undergo lateral opening between protofilaments, [RefSeq, PubMed]; Results describe the expression pattern of acetylated alpha-tubulin at different stages of testis development confirm that only Ac-alpha-Tu is specific to germ cells., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0005929 cilium;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2XVP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06AU6-1", "uniprot_id": "RAB5A_PIG", "mass": 23747.0, "length": 215, "protein_name": "Ras-related protein Rab-5A", "gene_name": "RAB5A", "organism": "Pig", "refseq_name": "ras-related protein Rab-5A", "refseq_ac": "NP_001116652", "gene_names_uniprotkb": "RAB5A", "gene_names_refseq": "RAB5A", "protein_names_uniprotkb": "Ras-related protein Rab-5A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5A", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144499); (R-SSC-8854214); (R-SSC-8856828); (R-SSC-8876198); (R-SSC-983231)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "19357169;27489278;32543654", "class_list": "", "function": "Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells., [RefSeq, PubMed]; Expression of dominant negative Rab5 and Rab7 mutants, but not the dominant negative Rab11 mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution (By similarity). Recruits RABEP1/Rabaptin-5 effector to early endosomes, thereby promoting endocytic membrane fusion (By similarity). Required for EGF and transferrin endocytosis and trafficking through early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06AU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLE3-1", "uniprot_id": "CATK_PIG", "mass": 37069.0, "length": 330, "protein_name": "Cathepsin K", "gene_name": "CTSK", "organism": "Pig", "refseq_name": "cathepsin K precursor", "refseq_ac": "NP_999467", "gene_names_uniprotkb": "CTSK", "gene_names_refseq": "CTSK", "protein_names_uniprotkb": "Cathepsin K; 3.4.22.38", "protein_names_refseq": "cathepsin K precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397569); (R-SSC-1442490); (R-SSC-1592389); (R-SSC-1679131); (R-SSC-2132295); (R-SSC-8939242)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "11082042;19662513;32543654", "class_list": "", "function": "The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values., [RefSeq, PubMed]; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0006590 thyroid hormone generation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9GLE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U9S1-1", "uniprot_id": "MBL1_PIG", "mass": 26489.0, "length": 249, "protein_name": "Mannose-binding protein A", "gene_name": "MBL1", "organism": "Pig", "refseq_name": "mannose-binding protein A precursor", "refseq_ac": "NP_001007195", "gene_names_uniprotkb": "MBL1; MBL-A", "gene_names_refseq": "MBL-A; MBL1; MBL2; MBP-A; pMBP-28", "protein_names_uniprotkb": "Mannose-binding protein A; 28 kDa mannan-binding protein monomeric subunit; MBL-A; MBP-A; Mannan-binding lectin A; Mannose-binding lectin A; pMBP-28", "protein_names_refseq": "28 kDa mannan-binding protein monomeric subunit; Mannan-binding lectin A; mannan-binding lectin (A); mannose-binding lectin 2; mannose-binding lectin A; mannose-binding protein A precursor; mannose-binding protein A", "tax_id": 9823, "disease": "", "pathway": " (ssc:492276)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11063327;16480769;16518621;17089118;17194476;17284229;21274526;32543654;8602463", "class_list": "", "function": "Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine on bacteria, including strains of A.suis, H.parasuis and A.pleuropneumoniae, and activates the lectin complement pathway. According to some authors, it only binds mannose (PubMed:8602463)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Single-strand conformational polymorphism (SSCP) analysis of MBL cDNAs from porcine liver revealed three SNPs within the coding region of MBL1 in various breeds of pigs., [RefSeq, PubMed]; The mannose-binding lectin A serum concentration in Duroc boars showed one single population, whereas Landrace boars showed four distinct populations. No association between serum mannose-binding lectin A and disease incidence was found., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0SVI9;Q9TR19;Q9TT24", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005509 calcium ion binding;GO:0005537 D-mannose binding;GO:0120153 calcium-dependent carbohydrate binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0050766 positive regulation of phagocytosis;GO:0070207 protein homotrimerization;GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5U9S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GKE7-1", "uniprot_id": "CLCN5_PIG", "mass": 90802.0, "length": 816, "protein_name": "H(+)/Cl(-) exchange transporter 5", "gene_name": "CLCN5", "organism": "Pig", "refseq_name": "H(+)/Cl(-) exchange transporter 5 isoform a", "refseq_ac": "NP_999304", "gene_names_uniprotkb": "CLCN5", "gene_names_refseq": "CLC-5; CLCN5", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; Chloride transporter ClC-5; ClC-5", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 5 isoform a; chloride channel protein 5; chloride transporter ClC-5; h(+)/Cl(-) exchange transporter 5; outwardly rectifying chloride channel", "tax_id": 9823, "disease": "", "pathway": " (ssc:397263); (R-SSC-2672351)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10978325;30723633;32543654", "class_list": "", "function": "Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:10978325). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BE85", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9GKE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71LE2-1", "uniprot_id": "H33_PIG", "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "H3-3A", "organism": "Pig", "refseq_name": "histone H3.3", "refseq_ac": "NP_999095", "gene_names_uniprotkb": "H3-3A; H3F3A", "gene_names_refseq": "H3-3A; H3F3A", "protein_names_uniprotkb": "Histone H3.3", "protein_names_refseq": "H3 histone, family 3A; histone H3.3A; histone H3.3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521680); (ssc:396970); (R-SSC-201722); (R-SSC-212300); (R-SSC-2299718); (R-SSC-2559580); (R-SSC-2559582); (R-SSC-427359); (R-SSC-5250924); (R-SSC-5578749); (R-SSC-5625886); (R-SSC-68616); (R-SSC-73728); (R-SSC-73772); (R-SSC-8936459); (R-SSC-9018519); (R-SSC-9670095); (R-SSC-9764725); (R-SSC-983231); (R-SSC-9841922); (R-SSC-9843940); (R-SSC-9843970); (R-SSC-9909649); (R-SSC-9940951); (R-SSC-9943411); (R-SSC-9943962); (R-SSC-9970672)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "21631284;32543654", "class_list": "", "function": "Data suggest the combination of three genes RPL32, RPS18, and H3F3A is the most suitable for accurate normalization., [RefSeq, PubMed]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0030307 positive regulation of cell growth;GO:0006334 nucleosome assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q71LE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08059-1", "uniprot_id": "G6PI_PIG", "mass": 63126.0, "length": 558, "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "GPI", "organism": "Pig", "refseq_name": "glucose-6-phosphate isomerase", "refseq_ac": "NP_999495", "gene_names_uniprotkb": "GPI", "gene_names_refseq": "GPI; PGI", "protein_names_uniprotkb": "Glucose-6-phosphate isomerase; 5.1.3.-; 5.3.1.9; AMF; Autocrine motility factor; D-hexose-6-phosphate anomerase; GPI; Glucose-6-phosphate C2-epimerase; NLK; Neuroleukin; PGI; PHI; Phosphoglucose isomerase; Phosphohexose isomerase", "protein_names_refseq": "AMF; D-hexose-6-phosphate anomerase; NLK; PHI; autocrine motility factor; glucose phosphate isomerase; glucose-6-phosphate C2-epimerase; glucose-6-phosphate isomerase; muscle phosphohexose isomerase; neuroleukin; phosphoglucose isomerase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397602); (R-SSC-5628897); (R-SSC-6798695); (R-SSC-70171); (R-SSC-70263)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "12402366;2248981;2889410;32543654;3352744;4475113;6115414;7821788", "class_list": "", "function": "Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (By similarity). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29556", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0005125 cytokine activity;GO:0004347 glucose-6-phosphate isomerase activity;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0010595 positive regulation of endothelial cell migration;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0006002 fructose 6-phosphate metabolic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q58D68-1", "uniprot_id": "ENPP6_PIG", "mass": 50356.0, "length": 440, "protein_name": "Glycerophosphocholine cholinephosphodiesterase ENPP6", "gene_name": "ENPP6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENPP6", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycerophosphocholine cholinephosphodiesterase ENPP6; 3.1.4.-; 3.1.4.38; Choline-specific glycerophosphodiester phosphodiesterase; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; GPC-Cpde; NPP-6", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152050)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15679890;16305752;17145712;32543654", "class_list": "", "function": "Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047390 glycerophosphocholine cholinephosphodiesterase activity;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q58D68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29228-1", "uniprot_id": "AL9A1_PIG", "mass": 53941.0, "length": 494, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase", "gene_name": "ALDH9A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ALDH9A1; ALDH9", "gene_names_refseq": "", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase; 1.2.1.19; 1.2.1.3; 1.2.1.46; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153809); (R-SSC-71262)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "32543654;8672129", "class_list": "", "function": "Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZNV5", "ec_number_list": "", "go_molecular_function": "GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity;GO:0140087 acetaldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O18896-1", "uniprot_id": "SOX9_PIG", "mass": 56267.0, "length": 509, "protein_name": "Transcription factor SOX-9", "gene_name": "SOX9", "organism": "Pig", "refseq_name": "transcription factor SOX-9", "refseq_ac": "NP_999008", "gene_names_uniprotkb": "SOX9", "gene_names_refseq": "SOX-9; SOX9", "protein_names_uniprotkb": "Transcription factor SOX-9", "protein_names_refseq": "SRY (sex determining region Y)-box 9; SRY-box 9; transcription factor SOX-9", "tax_id": 9823, "disease": "", "pathway": " (ssc:396840)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20950722;26430891;28580627;29254288;31319268", "class_list": "", "function": "Analysis of tissue maturation markers showed an increase in COLL II and a decrease in SOX9 expression in the swine tibial menisci with age., [RefSeq, PubMed]; Data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits Publication Status: Online-Only, [RefSeq, PubMed]; HIF-1alpha activates Sox9 expression and enhances Sox9-mediated transcriptional activity., [RefSeq, PubMed]; The expression of the differentiation and stemness genes, FN1 and SOX9, is accompanied by cell proliferation., [RefSeq, PubMed]; The indel polymorphism and expression of SOX9 were significantly associated with pig reproduction traits indicating the critical roles of SOX9 gene in testes development., [RefSeq, PubMed]; Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes. Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix. Controls epithelial branching during kidney development., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0001708 cell fate specification;GO:0003170 heart valve development;GO:0030858 positive regulation of epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O18896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O19069-2", "uniprot_id": "SUCA_PIG", "mass": 36117.0, "length": 346, "protein_name": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial", "gene_name": "SUCLG1", "organism": "Pig", "refseq_name": "succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial", "refseq_ac": "NP_999574", "gene_names_uniprotkb": "SUCLG1", "gene_names_refseq": "SCS; SUCLG1", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; 6.2.1.-; 6.2.1.4; 6.2.1.5; 6.2.1.9; Itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha; Malyl--CoA ligase [ADP/GDP-forming] subunit alpha; SCS-alpha; Succinyl-CoA synthetase subunit alpha", "protein_names_refseq": "SCS-alpha; itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha; malyl--CoA ligase [ADP/GDP-forming] subunit alpha; succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinate-CoA ligase alpha subunit; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; succinyl-CoA synthetase alpha subunit; succinyl-CoA synthetase subunit alpha", "tax_id": 9823, "disease": "", "pathway": " (ssc:399539); (R-SSC-71403)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10873456;14681463;16481318;26249701;27487822;9261120", "class_list": "", "function": "Pig GTP-specific succinyl-CoA synthetase was crystallized in the presence of succinate, magnesium ions and CoA, and the structure of the complex was determined by X-ray crystallography to 2.2 A resolution. Succinate binds in the carboxy-terminal domain of the beta-subunit., [RefSeq, PubMed]; Structure of GTP-specific succinyl-CoA synthetase subunits in complex with CoA has been resolved., [RefSeq, PubMed]; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:27487822). The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits (By similarity). Also able to act as an itaconyl- and malyl-CoA synthetase (By similarity)., [UniProtKB, HAMAP, PubMed]; Succinyl-CoA synthetase is able to protect GTP from hydrolysis when the active-site histidine residue is not in position to be phosphorylated, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O19068", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity;GO:0050074 malate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045244 succinate-CoA ligase complex (GDP-forming);GO:0009361 succinate-CoA ligase complex (ADP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O19069-2", "record_type": "protein" }, { "uniprot_canonical_ac": "O46491-1", "uniprot_id": "CP7A1_PIG", "mass": 56846.0, "length": 501, "protein_name": "Cytochrome P450 7A1", "gene_name": "CYP7A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CYP7A1; CYP7", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 7A1; 1.14.14.23; 1.14.14.26; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-192105); (R-SSC-193368); (R-SSC-193807); (R-SSC-211976)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis. 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008123 cholesterol 7-alpha-monooxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0033782 24S-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0006699 bile acid biosynthetic process;GO:0071333 cellular response to glucose stimulus;GO:0071397 cellular response to cholesterol;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O46491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46560-1", "uniprot_id": "PDXK_PIG", "mass": 35614.0, "length": 322, "protein_name": "Pyridoxal kinase", "gene_name": "PDXK", "organism": "Pig", "refseq_name": "pyridoxal kinase", "refseq_ac": "NP_999108", "gene_names_uniprotkb": "PDXK; PKH", "gene_names_refseq": "PDXK", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxine kinase", "tax_id": 9823, "disease": "", "pathway": " (ssc:396983)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14688239;9924807", "class_list": "", "function": "Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:9924807). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity)., [UniProtKB, UniProtKB, PubMed]; It appears that specific interactions occur between PK and pyridoxal-5-phosphate-dependent enzymes, and the binding affinities of PK for PLP-dependent enzymes decrease in the presence of PLP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008478 pyridoxal kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O46560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46658-1", "uniprot_id": "CP2DP_PIG", "mass": 56512.0, "length": 500, "protein_name": "Vitamin D(3) 25-hydroxylase", "gene_name": "CYP2D25", "organism": "Pig", "refseq_name": "vitamin D(3) 25-hydroxylase", "refseq_ac": "NP_999559", "gene_names_uniprotkb": "CYP2D25", "gene_names_refseq": "CYP2D25; CYP2D6; CYPIID25", "protein_names_uniprotkb": "Vitamin D(3) 25-hydroxylase; 1.14.14.24; CYPIID25; Cytochrome P450 2D25", "protein_names_refseq": "cytochrome P-450; cytochrome P450 2D25; cytochrome P450 2D6; cytochrome P450 family 2 subfamily D polypeptide 6; vitamin D(3) 25-hydroxylase; vitamin D-25-hydroxylase; vitamin D3 25-Hydroxylase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397687)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1445236;2169238;9425298", "class_list": "", "function": "Catalyzes the 25-hydroxylation of vitamin D(3) (calciol), 1alpha-hydroxyvitamin D(3) (alphacalcidiol) and some C27 steroids. In addition the enzyme catalyzes the hydroxylation of positions 11 and 12 of dodecanoate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0030343 vitamin D3 25-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62651-1", "uniprot_id": "WT1_PIG", "mass": 49166.0, "length": 449, "protein_name": "Wilms tumor protein homolog", "gene_name": "WT1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Wilms tumor protein homolog", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:397338)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9602131", "class_list": "", "function": "Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0003156 regulation of animal organ formation;GO:0007530 sex determination;GO:0035802 adrenal cortex formation;GO:2000020 positive regulation of male gonad development;GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O62651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62667-1", "uniprot_id": "S28A1_PIG", "mass": 70823.0, "length": 647, "protein_name": "Sodium/nucleoside cotransporter 1", "gene_name": "SLC28A1", "organism": "Pig", "refseq_name": "sodium/nucleoside cotransporter 1", "refseq_ac": "NP_999277", "gene_names_uniprotkb": "SLC28A1; CNT1; pkCNT1", "gene_names_refseq": "PKCNT1; SLC28A1", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter 1; CNT 1; Concentrative nucleoside transporter 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1", "protein_names_refseq": "CNT 1; Na(+)/nucleoside cotransporter 1; Na/nucleoside cotransporter; concentrative nucleoside transporter 1; sodium-coupled nucleoside transporter 1; sodium/nucleoside cotransporter 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397200)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9858747", "class_list": "", "function": "Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015861 cytidine transport;GO:0015862 uridine transmembrane transport;GO:0015855 pyrimidine nucleobase transport;GO:0180015 nucleoside import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O62667-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62714-1", "uniprot_id": "CASR_PIG", "mass": 120361.0, "length": 1079, "protein_name": "Extracellular calcium-sensing receptor", "gene_name": "CASR", "organism": "Pig", "refseq_name": "extracellular calcium-sensing receptor isoform X1", "refseq_ac": "XP_005654095", "gene_names_uniprotkb": "CASR; PCAR1", "gene_names_refseq": "CASR; PCAR1", "protein_names_uniprotkb": "Extracellular calcium-sensing receptor; CaSR; PCaR1; Parathyroid cell calcium-sensing receptor", "protein_names_refseq": "extracellular calcium-sensing receptor isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-416476); (R-SSC-418594); (R-SSC-420499)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10449918;26290606", "class_list": "", "function": "G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G proteins depending on the context. In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity. The G protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation. Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (By similarity). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "F1SQ21;O62715;O62716", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0006874 intracellular calcium ion homeostasis;GO:0051924 regulation of calcium ion transport;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O62714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62786-1", "uniprot_id": "GTR2_PIG", "mass": 57263.0, "length": 524, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2", "gene_name": "SLC2A2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC2A2; GLUT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-189200); (R-SSC-422356); (R-SSC-8981373)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30723633", "class_list": "", "function": "Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate and urate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "I3LNT8", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O62786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77564-1", "uniprot_id": "FOLH1_PIG", "mass": 84524.0, "length": 751, "protein_name": "Glutamate carboxypeptidase 2", "gene_name": "FOLH1", "organism": "Pig", "refseq_name": "glutamate carboxypeptidase 2", "refseq_ac": "NP_999549", "gene_names_uniprotkb": "FOLH1; NAALAD1", "gene_names_refseq": "FOLH1B; FOLH1; NAALAD1", "protein_names_uniprotkb": "Glutamate carboxypeptidase 2; 3.4.17.21; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen homolog; Pteroylpoly-gamma-glutamate carboxypeptidase; mGCP", "protein_names_refseq": "FGCP; GCPII; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; mGCP; membrane glutamate carboxypeptidase; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397677)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18076021;19033540;2867095;9685395", "class_list": "", "function": "Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC., [UniProtKB]; Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate., [UniProtKB]; Intestinal GCPII and intestinal and hepatic RFC all exhibit ontogenic changes in the pig that are reflected in postnatal folate status, [RefSeq, PubMed]; Tissues such as prostate and testes exhibit different GCPII expression levels among the species studied (human, rats, swine)., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O77564-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77636-1", "uniprot_id": "ADA17_PIG", "mass": 93544.0, "length": 833, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "organism": "Pig", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 17 precursor", "refseq_ac": "NP_001093396", "gene_names_uniprotkb": "ADAM17; TACE", "gene_names_refseq": "ADAM17; TACE", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 17; 3.4.24.86; ADAM 17; TNF-alpha convertase; TNF-alpha-converting enzyme", "protein_names_refseq": "ADAM 17; TNF-alpha convertase; TNF-alpha converting enzyme; a disintegrin and metallopeptidase domain 17; disintegrin and metalloproteinase domain-containing protein 17 precursor; disintegrin and metalloproteinase domain-containing protein 17", "tax_id": 9823, "disease": "", "pathway": " (ssc:397343)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10429942;20168049;23389627;24424050;24965453;26653711;26724939;33684175", "class_list": "", "function": "(Microbial infection) Acts as a receptor for classical swine fever virus., [UniProtKB, PubMed]; ADAM17 was involved in porcine CD16 shedding in porcine reproductive and respiratory syndrome virus-infected pigs., [RefSeq, PubMed]; Activation of TACE/ADAM17 via a PKC-induced c-Src-dependent manner mediates proteolytic activation of the EGF-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes, [RefSeq, PubMed]; Data indicate that TNF-alpha stimulates Rac, ADAM17/TACE, and RhoA through the guanine nucleotide exchange factor (GEF)-H1., [RefSeq, PubMed]; Overexpression of ADAM17 induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection. Erratum:[J Virol. 2016 May 12;90(11):5532. doi: 10.1128/JVI.00536-16. PMID: 27174637], [RefSeq, PubMed]; Progesterone-induced TACE/ADAM17 leads to production of soluble EGF domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes, [RefSeq, PubMed]; These findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy, [RefSeq, PubMed]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (By similarity). Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 (By similarity). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5A749", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O77636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77668-1", "uniprot_id": "OREX_PIG", "mass": 13457.0, "length": 131, "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "HCRT", "organism": "Pig", "refseq_name": "hypocretin neuropeptide precursor precursor", "refseq_ac": "NP_999321", "gene_names_uniprotkb": "HCRT; ORX; OX; PPOX", "gene_names_refseq": "HCRT", "protein_names_uniprotkb": "Hypocretin neuropeptide precursor; Hcrt1; Hcrt2; Hcrt; Hypocretin-1; Hypocretin-2; Hypocretin; Orexin precursor; Prepro-orexin; Preprohypocretin", "protein_names_refseq": "hypocretin neuropeptide precursor precursor; orexin-A; orexin-B; prepro-orexin; preprohypocretin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397305); (R-SSC-389397); (R-SSC-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10343916;10754114;20359730;21888930;23220034;23568972;29550793", "class_list": "", "function": "Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; In summary, we revealed an important role of orexin A in the regulation of pancreatic islets biology. OxA is involved in the secretion of pancreatic hormones and prolongation of islet cell lifespan., [RefSeq, PubMed]; MBH, signal intensity for OXA was highest on days 14-16., [RefSeq, PubMed]; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested., [UniProtKB, UniProtKB]; Orexin A was found in the beta cells of cattle, sheep, and swine where it may be implicated in the control of pancreatic activity., [RefSeq, PubMed]; Prepro-orexin (PPOX) mRNA abundance was approximately 15-fold higher (P<0.05) in mandibular than in the others salivary glands., [RefSeq, PubMed]; The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q000Y9;Q9TTA6", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031771 type 1 orexin receptor binding;GO:0031772 type 2 orexin receptor binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007218 neuropeptide signaling pathway;GO:0042594 response to starvation;GO:0042755 eating behavior;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O77668-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77736-1", "uniprot_id": "TNR6_PIG", "mass": 37593.0, "length": 332, "protein_name": "Tumor necrosis factor receptor superfamily member 6", "gene_name": "FAS", "organism": "Pig", "refseq_name": "tumor necrosis factor receptor superfamily member 6 precursor", "refseq_ac": "NP_999004", "gene_names_uniprotkb": "FAS; APT1; TNFRSF6", "gene_names_refseq": "APT1; FAS; TNFRSF6", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor", "protein_names_refseq": "FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas receptor; apo-1 antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily member 6 precursor; tumor necrosis factor receptor superfamily member 6", "tax_id": 9823, "disease": "", "pathway": " (ssc:396826); (R-SSC-3371378); (R-SSC-5218900); (R-SSC-69416); (R-SSC-75157)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "15303979;17321702", "class_list": "", "function": "Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta Erratum:[Xenotransplantation. 2016 Mar;23(2):171-2. doi: 10.1111/xen.12200. PMID: 27106874], [RefSeq, PubMed]; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity)., [UniProtKB, UniProtKB]; The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0031265 CD95 death-inducing signaling complex", "go_biological_process": "GO:0006955 immune response;GO:0043066 negative regulation of apoptotic process;GO:0097191 extrinsic apoptotic signaling pathway;GO:0006924 activation-induced cell death of T cells;GO:0097049 motor neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O77736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77737-1", "uniprot_id": "B2CL1_PIG", "mass": 26061.0, "length": 233, "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "organism": "Pig", "refseq_name": "bcl-2-like protein 1", "refseq_ac": "NP_999450", "gene_names_uniprotkb": "BCL2L1; BCLX; BLC2L", "gene_names_refseq": "BCL2L1", "protein_names_uniprotkb": "Bcl-2-like protein 1; Apoptosis regulator Bcl-X; Bcl2-L-1", "protein_names_refseq": "anti-apoptotic Bcl-xL; apoptosis regulator Bcl-X; bcl-2-like protein 1; bcl2-L-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397536)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10072723;15984157;16616078;19520150;21884347", "class_list": "", "function": "Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis, [RefSeq, PubMed]; CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time., [RefSeq, PubMed]; Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-12p40, IL-1beta, and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1., [RefSeq, PubMed]; Interleukin-6, endothelin ET-1, and apoptotic Bak and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury, [RefSeq, PubMed]; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051707 response to other organism;GO:0006897 endocytosis;GO:0043065 positive regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O77737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97562-1", "uniprot_id": "UCP2_PIG", "mass": 33259.0, "length": 309, "protein_name": "Dicarboxylate carrier UCP2", "gene_name": "UCP2", "organism": "Pig", "refseq_name": "dicarboxylate carrier UCP2", "refseq_ac": "NP_999454", "gene_names_uniprotkb": "UCP2; SLC25A8", "gene_names_refseq": "SLC25A8; UCP2", "protein_names_uniprotkb": "Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2", "protein_names_refseq": "UCP 2; dicarboxylate carrier SLC25A8; dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein homolog", "tax_id": 9823, "disease": "", "pathway": " (ssc:397549); (R-SSC-167826)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17221299;17383207;25199570", "class_list": "", "function": "Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression., [RefSeq, PubMed]; Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3, showing that UCPs have conservation and genetic reliability., [RefSeq, PubMed]; The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 expression in selected muscles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q19B01;Q5XQS5;Q9GK29", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015297 antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009409 response to cold;GO:0071333 cellular response to glucose stimulus;GO:0006096 glycolytic process;GO:0072593 reactive oxygen species metabolic process;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O97562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97676-1", "uniprot_id": "SRBP1_PIG", "mass": 121502.0, "length": 1151, "protein_name": "Sterol regulatory element-binding protein 1", "gene_name": "SREBF1", "organism": "Pig", "refseq_name": "sterol regulatory element-binding protein 1 isoform 1", "refseq_ac": "NP_999322", "gene_names_uniprotkb": "SREBF1; ADD1; SREBP1", "gene_names_refseq": "ADD1; SCREBP1; SREBF1c; SREBF1; SREBP-1C; SREBP-1; SREBP1", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 1; Adipocyte determination and differentiation-dependent factor 1; SREBP-1; Sterol regulatory element-binding transcription factor 1; Transcription factor SREBF1", "protein_names_refseq": "adipocyte determination and differentiation-dependent factor 1; sterol regulatory binding transcription factor 1; sterol regulatory element-binding protein 1 isoform 1; sterol regulatory element-binding protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397308)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10481259;14998783;16520310;17878274;20017192;23657179;23825667;28367099;37052853", "class_list": "", "function": "Basal transcription and supra-additive stimulation of porcine LDLR gene transcription by LH and insulin in granulosa-luteal cells require SREBP-1a and Sp1/Sp3-binding elements., [RefSeq, PubMed]; DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis., [RefSeq, PubMed]; Dysregulation of SIRT1-AMPK-SREBP and stimulation of NLRP3 inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis Publication Status: Online-Only, [RefSeq, PubMed]; IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection., [RefSeq, PubMed]; In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS, Acetyl-CoA carboxylase alpha (ACCalpha), and less hepatic and plasma TG after being fed a high-fat diet. Publication Status: Online-Only, [RefSeq, PubMed]; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation., [UniProtKB, UniProtKB]; Polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits., [RefSeq, PubMed]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF) and back fat thickness (BF)., [RefSeq, PubMed]; SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q1W0S6;Q6RIB9;Q7YS02", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008203 cholesterol metabolic process;GO:0008610 lipid biosynthetic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O97676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97788-1", "uniprot_id": "FABP4_PIG", "mass": 14676.0, "length": 132, "protein_name": "Fatty acid-binding protein, adipocyte", "gene_name": "FABP4", "organism": "Pig", "refseq_name": "fatty acid-binding protein, adipocyte", "refseq_ac": "NP_001002817", "gene_names_uniprotkb": "FABP4", "gene_names_refseq": "A-FABP; AFABP; ALBP; AP2; FABP3; FABP4", "protein_names_uniprotkb": "Fatty acid-binding protein, adipocyte; A-FABP; AFABP; ALBP; AP2; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4", "protein_names_refseq": "adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; fatty acid binding protein 4, adipocyte; fatty acid-binding protein, adipocyte", "tax_id": 9823, "disease": "", "pathway": " (ssc:399533); (R-SSC-163560)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17057239;17942849;21846497;23135696;2334399;23372061;29076225;9880671", "class_list": "", "function": "AFABP is significantly increased in coronary artery in-stent restenosis segments of both diabetic and nondiabetic minipigs., [RefSeq, PubMed]; FABP4 gene expression level in adipose tissue was higher than in muscle. In contrast, FABP5 was expressed at low levels in adipocytes and muscle tissues. Low and moderate correlations between FABP4 and FABP5 gene expression were observed in muscle and in backfat, respectively., [RefSeq, PubMed]; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion (PubMed:9880671)., [UniProtKB, UniProtKB, PubMed]; Regenerated coronary endothelial cells exhibit upregulation of adipocyte fatty acid binding protein (A-FABP) Erratum:[Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e13], [RefSeq, PubMed]; The A-FABP gene is strongly related to the development and function of intramuscular fat accretion in pigs., [RefSeq, PubMed]; Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0SXU3;A0SXU5;A0SXV1;A0SXV2;A0SXW5", "ec_number_list": "", "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0051427 hormone receptor binding;GO:0060229 lipase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport;GO:0019433 triglyceride catabolic process;GO:0015909 long-chain fatty acid transport;GO:0120162 positive regulation of cold-induced thermogenesis;GO:0070346 positive regulation of fat cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O97788-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00371-1", "uniprot_id": "OXDA_PIG", "mass": 39336.0, "length": 347, "protein_name": "D-amino-acid oxidase", "gene_name": "DAO", "organism": "Pig", "refseq_name": "D-amino-acid oxidase", "refseq_ac": "NP_999231", "gene_names_uniprotkb": "DAO", "gene_names_refseq": "DAAO; DAMOX; DAO1; DAO", "protein_names_uniprotkb": "D-amino-acid oxidase; 1.4.3.3; DAAO; DAMOX; DAO", "protein_names_refseq": "D-amino-acid oxidase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397134); (R-SSC-389661); (R-SSC-9033241)", "pathway_count": 3, "publication_count": 32, "publication_id_list": "10876160;15058991;15928834;16245349;1673125;16751595;17469229;18507366;18634432;20603179;22271930;24492954;24644036;25425233;2575382;27648606;27670111;28592826;2888479;2893757;2901989;2904274;2905598;30333894;33725110;6120171;6124543;6129252;8755502;8864836;9153426;9399588", "class_list": "", "function": "Catalyzes the oxidation of D-amino acid to imino acid and its three dimensional structure is determined. Review article, [RefSeq, PubMed]; Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:10876160, PubMed:16751595, PubMed:17469229, PubMed:20603179, PubMed:24492954, PubMed:24644036, PubMed:28592826, PubMed:2904274, PubMed:30333894). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (By similarity). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (By similarity). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (By similarity). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (By similarity). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (PubMed:22271930, PubMed:25425233, PubMed:27670111). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (By similarity). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (By similarity). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DAO suppressed the growth of Staphylococcus aureus in a manner that depended on the concentration of DAO and D-amino acid in vitro; results suggest that DAO, together with myeloperoxidase, may play an important role in antibacterial systems in mammals, [RefSeq, PubMed]; Expression of Histamine N-Methyltransferase and Diamine Oxidase in porcine tissues, [RefSeq, PubMed]; The thermostable mutant DAO from porcine kidney by a single amino acid substitution, F42C, was stable at 55 degrees C, while the wild-type enzyme was stable only up to 45 degrees C., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AV04;A0A4X1SRS8", "ec_number_list": "", "go_molecular_function": "GO:0071949 FAD binding;GO:0003884 D-amino-acid oxidase activity;GO:0043799 glycine oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0019478 D-amino acid catabolic process;GO:0036088 D-serine catabolic process;GO:0055130 D-alanine catabolic process;GO:0042416 dopamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P00371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00503-1", "uniprot_id": "AATC_PIG", "mass": 46475.0, "length": 413, "protein_name": "Aspartate aminotransferase, cytoplasmic", "gene_name": "GOT1", "organism": "Pig", "refseq_name": "aspartate aminotransferase, cytoplasmic", "refseq_ac": "NP_999092", "gene_names_uniprotkb": "GOT1", "gene_names_refseq": "CASPAT; GOT1; cCAT", "protein_names_uniprotkb": "Aspartate aminotransferase, cytoplasmic; 2.6.1.1; 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A; cAspAT; cCAT", "protein_names_refseq": "aspartate aminotransferase, cytoplasmic; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); transaminase A", "tax_id": 9823, "disease": "", "pathway": " (ssc:396967); (R-SSC-8963693); (R-SSC-9856872)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11946901;1239277;19968637;2653435;4634443;5809231;9211866", "class_list": "", "function": "Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:4634443). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity)., [UniProtKB, PubMed, UniProtKB]; GOT1 is a suitable candidate gene for the serum aspartate aminotransferase activity QTL on SSC14., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609 phosphatidylserine decarboxylase activity;GO:0047801 L-cysteine transaminase activity;GO:0120554 2-aminobutanoate transaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00506-1", "uniprot_id": "AATM_PIG", "mass": 47436.0, "length": 430, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "GOT2", "organism": "Pig", "refseq_name": "aspartate aminotransferase, mitochondrial precursor", "refseq_ac": "NP_999093", "gene_names_uniprotkb": "GOT2", "gene_names_refseq": "GOT2", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; 2.6.1.7; FABP-1; FABPpm; Fatty acid-binding protein; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; Transaminase A; mAspAT", "protein_names_refseq": "FABP-1; FABPpm; aspartate aminotransferase, mitochondrial precursor; aspartate aminotransferase, mitochondrial; fatty acid-binding protein; glutamate oxaloacetate transaminase 2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A", "tax_id": 9823, "disease": "", "pathway": " (ssc:396968); (R-SSC-389661); (R-SSC-8963693); (R-SSC-8964539); (R-SSC-9856872)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "121997;19172260;3862118;7391012;7408859;8672129", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids., [UniProtKB, UniProtKB]; Thermal aggregation of aspartate aminotransferase from pig heart mitochondria (mAAT) has been studied at various temperatures and various protein concentrations by dynamic light scattering., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29230", "ec_number_list": "", "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0006869 lipid transport;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P00506-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00591-1", "uniprot_id": "LIPP_PIG", "mass": 50084.0, "length": 450, "protein_name": "Pancreatic triacylglycerol lipase", "gene_name": "PNLIP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PNLIP", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreatic triacylglycerol lipase; 3.1.1.3; PL; PTL; Pancreatic lipase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "3691527;380992;518929;6791692;7151781;7326260;8663362", "class_list": "", "function": "Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00690-1", "uniprot_id": "AMYP_PIG", "mass": 57086.0, "length": 511, "protein_name": "Pancreatic alpha-amylase", "gene_name": "AMY2", "organism": "Pig", "refseq_name": "pancreatic alpha-amylase precursor", "refseq_ac": "NP_999360", "gene_names_uniprotkb": "AMY2", "gene_names_refseq": "AMY2B; AMY2", "protein_names_uniprotkb": "Pancreatic alpha-amylase; 1,4-alpha-D-glucan glucanohydrolase; 3.2.1.1; PA", "protein_names_refseq": "1,4-alpha-D-glucan glucanohydrolase; PA; PPA; alpha-amylase; pancreatic alpha-amylase precursor; pancreatic alpha-amylase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397397)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10082956;11412124;11960990;12962327;15517985;15736930;27066537;3484639;3502087;6188459;7897663;8193143;8515451;8681972;8757803;8994970;9385631", "class_list": "", "function": "X-ray crystallographic structure of the pig pancreatic alpha-amylase complexed with rho-nitrophenyl-alpha-D-maltoside-flexibility in the active site, [RefSeq, PubMed]; X-ray crystallography study of pancreatic alpha-amylase (PPA) explains the mechanism of PPA activation by chloride ions., [RefSeq, PubMed]; X-ray map of a pig pancreatic alpha-amylase crystal soaked (and flash-frozen) with a maltopentaose substrate showed a pattern of electron density corresponding to the binding of oligosaccharides at the active site and at three surface binding sites, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9TUE4", "ec_number_list": "", "go_molecular_function": "GO:0031404 chloride ion binding;GO:0005509 calcium ion binding;GO:0004556 alpha-amylase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016052 carbohydrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P00690-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00752-1", "uniprot_id": "KLK_PIG", "mass": 27172.0, "length": 246, "protein_name": "Glandular kallikrein", "gene_name": "", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Glandular kallikrein; 3.4.21.35; Tissue kallikrein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "2379280;3196708;3246048;6188842;6551452;7043199;9032072", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00761-1", "uniprot_id": "TRYP_PIG", "mass": 24409.0, "length": 231, "protein_name": "Trypsin", "gene_name": "", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Trypsin; 3.4.21.4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10771427;14020231;1551419;34019948;37217939;41018975;4738933;7947985;8445634;9242660;9384562", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00791-1", "uniprot_id": "PEPA_PIG", "mass": 41262.0, "length": 385, "protein_name": "Pepsin A", "gene_name": "PGA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PGA", "gene_names_refseq": "", "protein_names_uniprotkb": "Pepsin A; 3.4.23.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5683826)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "1097438;1594574;2056534;2115088;2217165;2415509;2494172;3044927;339692;4584879;4604255;4881358;4897201", "class_list": "", "function": "Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29080", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00795-1", "uniprot_id": "CATD_PIG", "mass": 37295.0, "length": 345, "protein_name": "Cathepsin D", "gene_name": "CTSD", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CTSD", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathepsin D; 3.4.23.5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "3182800;6406481;6422853;6587385", "class_list": "", "function": "Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0042470 melanosome", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01025-1", "uniprot_id": "CO3_PIG", "mass": 186807.0, "length": 1661, "protein_name": "Complement C3", "gene_name": "C3", "organism": "Pig", "refseq_name": "complement C3 precursor", "refseq_ac": "NP_999174", "gene_names_uniprotkb": "C3", "gene_names_refseq": "C3d; C3", "protein_names_uniprotkb": "Complement C3; C3adesArg; Complement C3b-alpha' chain", "protein_names_refseq": "complement C3 precursor; complement component C3", "tax_id": 9823, "disease": "", "pathway": " (ssc:397072)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11419349;12557058;12927082;33847930;956663", "class_list": "", "function": "Acts as a chemoattractant for neutrophils in chronic inflammation., [UniProtKB, UniProtKB]; Adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial triglyceride clearance. Appears to stimulate triglyceride synthesis via activation of the PLC, MAPK and AKT signaling pathways. Acts by binding to its receptor, C5AR2, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C5AR2. In contrast to C3a anaphylatoxin peptide, does not show pro-inflammatory activity., [UniProtKB, UniProtKB]; Mediator of local inflammatory process released following cleavage by C3 convertase. Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1. C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development. Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants., [UniProtKB, UniProtKB]; Non-enzymatic component of C5 convertase. Generated following cleavage by C3 convertase, it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. Complement C3b binds covalently via its reactive thioester, to cell surface carbohydrates or immune aggregates. Together with complement C4b, it then recruits the serine protease complement C2b to form the C5 convertase, which cleaves and activate C5, the next component of the complement pathways. In the alternative complement pathway, recruits the serine protease CFB to form the C5 convertase that cleaves and activates C5., [UniProtKB, UniProtKB]; Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, PubMed, PubMed]; Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O97940;Q9GKP1", "ec_number_list": "", "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0003823 antigen binding;GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005601 classical-complement-pathway C3/C5 convertase complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006631 fatty acid metabolic process;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01025-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01183-1", "uniprot_id": "NEU2_PIG", "mass": 17196.0, "length": 166, "protein_name": "Vasopressin-neurophysin 2-copeptin", "gene_name": "AVP", "organism": "Pig", "refseq_name": "vasopressin-neurophysin 2-copeptin precursor", "refseq_ac": "NP_999117", "gene_names_uniprotkb": "AVP", "gene_names_refseq": "AVP", "protein_names_uniprotkb": "Vasopressin-neurophysin 2-copeptin; AVP-NPII; Neurophysin-I/-III", "protein_names_refseq": "AVP-NPII; arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal); neurophysin; vasopressin-neurophysin 2-copeptin precursor; vasopressin-neurophysin 2-copeptin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396995); (R-SSC-388479); (R-SSC-416476); (R-SSC-432040); (R-SSC-879518); (R-SSC-8856825); (R-SSC-8856828)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "1001445;1971513;25001668;3768139;465021;4673067;4940405;944186", "class_list": "", "function": "Atrial natriuretic peptide and vasopressin-presence in the ciliary body of eye in the pig (sus domesticus)., [RefSeq, PubMed]; Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, UniProtKB]; Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2)., [UniProtKB, UniProtKB]; Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031894 V1A vasopressin receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0002125 maternal aggressive behavior;GO:0035556 intracellular signal transduction;GO:0003084 positive regulation of systemic arterial blood pressure;GO:0045907 positive regulation of vasoconstriction;GO:0042310 vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P01183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01192-1", "uniprot_id": "COLI_PIG", "mass": 28895.0, "length": 267, "protein_name": "Pro-opiomelanocortin", "gene_name": "POMC", "organism": "Pig", "refseq_name": "pro-opiomelanocortin precursor", "refseq_ac": "NP_999023", "gene_names_uniprotkb": "POMC", "gene_names_refseq": "POMC", "protein_names_uniprotkb": "Pro-opiomelanocortin; ACTH; Adrenocorticotropic hormone; Beta-LPH; Corticotropin-lipotropin; Gamma-LPH; Gamma-MSH; Melanotropin alpha; Melanotropin beta; POMC", "protein_names_refseq": "corticotropin-lipotropin; pro-opiomelanocortin precursor; pro-opiomelanocortin; proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)", "tax_id": 9823, "disease": "", "pathway": " (ssc:396863)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "1007884;1207728;13348631;13451616;17023126;18277703;2174774;3753882;4334191;4369114;4673865;5543613;6196724;6547437;7958386", "class_list": "", "function": "Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes., [UniProtKB]; Endogenous opiate., [UniProtKB]; Endogenous orexigenic opiate., [UniProtKB]; Increases the pigmentation of skin by increasing melanin production in melanocytes., [UniProtKB]; Porcine follicular cells (especially granulosa cells) may produce opioid peptides and that gonadotropins may modulate gene expression of their precursors in these cells., [RefSeq, PubMed]; Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation., [UniProtKB, UniProtKB]; Stimulates the adrenal glands to release cortisol., [UniProtKB]; The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95246", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:2000852 regulation of corticosterone secretion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P01192-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01214-1", "uniprot_id": "PDYN_PIG", "mass": 28617.0, "length": 256, "protein_name": "Proenkephalin-B", "gene_name": "PDYN", "organism": "Pig", "refseq_name": "proenkephalin-B preproprotein", "refseq_ac": "NP_001004040", "gene_names_uniprotkb": "PDYN", "gene_names_refseq": "PDYN", "protein_names_uniprotkb": "Proenkephalin-B; Beta-neoendorphin-dynorphin; Dyn-B; Dynorphin B(1-13); Dynorphin B-29; Dynorphin B; Preprodynorphin", "protein_names_refseq": "beta-neoendorphin-dynorphin; preprodynorphin; proenkephalin-B preproprotein; proenkephalin-B", "tax_id": 9823, "disease": "", "pathway": " (ssc:445529)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17023126;18277703;230519;6123953;6689399;7191256", "class_list": "", "function": "Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin., [UniProtKB]; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)., [UniProtKB]; Leumorphin has a typical opioid activity and may have anti-apoptotic effect., [UniProtKB]; Porcine follicular cells (especially granulosa cells) may produce opioid peptides and that gonadotropins may modulate gene expression of their precursors in these cells., [RefSeq, PubMed]; The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01214-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01238-1", "uniprot_id": "PRL_PIG", "mass": 26141.0, "length": 229, "protein_name": "Prolactin", "gene_name": "PRL", "organism": "Pig", "refseq_name": "prolactin precursor", "refseq_ac": "NP_999091", "gene_names_uniprotkb": "PRL", "gene_names_refseq": "PRL", "protein_names_uniprotkb": "Prolactin; PRL", "protein_names_refseq": "prolactin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396965); (R-SSC-1170546); (R-SSC-982772)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1270193;14559722;17463060;19675522;2344390;2726463", "class_list": "", "function": "Despite a lack of clear relationship between PRL/C499T polymorphism in 5' UTR of the PRL gene and plasma prolactin cioncentration, gene polymorphism impact on reproductiove performance cannot be excluded, [RefSeq, PubMed]; Iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction, [RefSeq, PubMed]; Prolactin acts primarily on the mammary gland by promoting lactation., [UniProtKB]; Prolactin and, to a lesser extent progesterone, which increase in early pregnancy, enhance basal and glucose-stimulated insulin secretion in part by increasing glucokinase activity and amplifying cAMP levels., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0031667 response to nutrient levels;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01238-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01248-1", "uniprot_id": "SOMA_PIG", "mass": 24429.0, "length": 216, "protein_name": "Somatotropin", "gene_name": "GH1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Somatotropin; Growth hormone", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1170546); (R-SSC-422085); (R-SSC-982772)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1343826;2182128;2491309;3666458;4918150;6303731", "class_list": "", "function": "Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28958;Q29045", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0048513 animal organ development;GO:0060396 growth hormone receptor signaling pathway;GO:0060397 growth hormone receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01269-1", "uniprot_id": "PTHY_PIG", "mass": 12852.0, "length": 115, "protein_name": "Parathyroid hormone", "gene_name": "PTH", "organism": "Pig", "refseq_name": "parathyroid hormone precursor", "refseq_ac": "NP_999566", "gene_names_uniprotkb": "PTH", "gene_names_refseq": "PTH", "protein_names_uniprotkb": "Parathyroid hormone; PTH; Parathyrin", "protein_names_refseq": "parathyrin; parathyroid hormone precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:399502); (R-SSC-373080)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1164500;3628009;4840833", "class_list": "", "function": "Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031857 type 1 parathyroid hormone receptor binding;GO:0031856 parathyroid hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010629 negative regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0030501 positive regulation of bone mineralization;GO:0045725 positive regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P01269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01315-1", "uniprot_id": "INS_PIG", "mass": 11672.0, "length": 108, "protein_name": "Insulin", "gene_name": "INS", "organism": "Pig", "refseq_name": "insulin precursor", "refseq_ac": "NP_001103242", "gene_names_uniprotkb": "INS", "gene_names_refseq": "INS", "protein_names_uniprotkb": "Insulin", "protein_names_refseq": "insulin precursor; preproinsulin; proinsulin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397415); (R-SSC-264876); (R-SSC-422085); (R-SSC-6807878); (R-SSC-6811558); (R-SSC-74713); (R-SSC-74749); (R-SSC-74751); (R-SSC-74752); (R-SSC-77387)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "12140686;14574411;15019281;15299880;1772633;2025410;28445749;2905485;29691708;30267353;31394126;32663503;5657063", "class_list": "", "function": "Effect of insulin on natriuretic peptide gene expression in porcine heart., [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]; Negative feedback loops between spexin and insulin found, indicating the presence of multilateral relationships between glucose, insulin, and spexin inside pancreatic islets, [RefSeq, PubMed]; Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions., [RefSeq, PubMed]; These findings revealed that acute myocardial insulin resistance due to inactivation of Akt played a key role in cardiac dysfunction post cardiopulmonary bypass via suppressing glucose metabolism related energy supply., [RefSeq, PubMed]; We expect that these insulin-deficient pigs can be used in diabetes research to test the efficacy and safety of new drugs and the recipient of islet transplantation to investigate optimal transplantation strategies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TSJ5", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0050709 negative regulation of protein secretion;GO:0045818 negative regulation of glycogen catabolic process;GO:0045922 negative regulation of fatty acid metabolic process;GO:0046631 alpha-beta T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P01315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01348-1", "uniprot_id": "RELX_PIG", "mass": 20818.0, "length": 182, "protein_name": "Prorelaxin", "gene_name": "RLN", "organism": "Pig", "refseq_name": "prorelaxin precursor", "refseq_ac": "NP_999037", "gene_names_uniprotkb": "RLN", "gene_names_refseq": "RLN2; RLN", "protein_names_uniprotkb": "Prorelaxin", "protein_names_refseq": "preprorelaxin; prorelaxin precursor; prorelaxin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396891)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21251292;21272344;21317299;23946288;2442155;24640560;622170;6897721;843375;851452;876374;887933;938497", "class_list": "", "function": "Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin., [RefSeq, PubMed]; Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2-like1/Bax-independent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals., [UniProtKB]; Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues., [RefSeq, PubMed]; Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts). Publication Status: Online-Only, [RefSeq, PubMed]; Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0030317 flagellated sperm motility;GO:0001556 oocyte maturation;GO:0046326 positive regulation of D-glucose import;GO:0050679 positive regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P01348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02067-1", "uniprot_id": "HBB_PIG", "mass": 16166.0, "length": 147, "protein_name": "Hemoglobin subunit beta", "gene_name": "HBB", "organism": "Pig", "refseq_name": "hemoglobin subunit beta", "refseq_ac": "NP_001138313", "gene_names_uniprotkb": "HBB", "gene_names_refseq": "HBB", "protein_names_uniprotkb": "Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain", "protein_names_refseq": "Beta-globin; Hemoglobin beta chain; hemoglobin subunit beta", "tax_id": 9823, "disease": "", "pathway": " (ssc:407066)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10713517;23487454;565742;7990139", "class_list": "", "function": "In this study, hemoglobin subunit beta was identified as a classical swine fever virus capsid protein-binding protein by glutathione S-transferase pulldown and subsequent mass spectrometry analysis of PK-15 cells., [RefSeq, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29025", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02547-1", "uniprot_id": "NFL_PIG", "mass": 62072.0, "length": 549, "protein_name": "Neurofilament light polypeptide", "gene_name": "NEFL", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NEFL", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurofilament light polypeptide; 68 kDa neurofilament protein; NF-L; Neurofilament triplet L protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10872323;3920075", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton", "go_cellular_component": "GO:0030424 axon;GO:0005882 intermediate filament;GO:1904115 axon cytoplasm;GO:0005883 neurofilament;GO:0099160 postsynaptic intermediate filament cytoskeleton", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0008089 anterograde axonal transport;GO:0045109 intermediate filament organization;GO:0019896 axonal transport of mitochondrion;GO:0033693 neurofilament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02550-1", "uniprot_id": "TBA1A_PIG", "mass": 50068.0, "length": 451, "protein_name": "Tubulin alpha-1A chain", "gene_name": "TUBA1A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TUBA1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin alpha-1A chain; 3.6.5.-; Alpha-tubulin 1; Tubulin alpha-1 chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "6204858;6688710;7019911;7225365", "class_list": "", "function": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02554-1", "uniprot_id": "TBB_PIG", "mass": 49861.0, "length": 445, "protein_name": "Tubulin beta chain", "gene_name": "", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin beta chain; Beta-tubulin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "10660047;11030624;11700061;26482847;27452403;3170578;6688710;6945576;7225365;9428769", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03970-1", "uniprot_id": "INHBA_PIG", "mass": 47476.0, "length": 424, "protein_name": "Inhibin beta A chain", "gene_name": "INHBA", "organism": "Pig", "refseq_name": "inhibin beta A chain precursor", "refseq_ac": "NP_001421819", "gene_names_uniprotkb": "INHBA", "gene_names_refseq": "INHBA", "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain", "protein_names_refseq": "activin beta-A chain; inhibin beta A chain precursor; inhibin beta A chain; inhibin beta A subunit; inhibin beta-subunit; inhibin, beta A (activin A, activin AB alpha polypeptide)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397093); (R-SSC-1502540); (R-SSC-201451); (R-SSC-209822); (R-SSC-2473224); (R-SSC-9839406)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "1644823;17010559;23226944;24134883;2417121", "class_list": "", "function": "Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression. Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation. Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway. In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling., [UniProtKB, UniProtKB]; An increased expression of Inhibin-beta A was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation., [RefSeq, PubMed]; INHA and INHB expression and cellular localization in porcine oocytes were studied., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition., [UniProtKB, UniProtKB]; Results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0017046 peptide hormone binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P03970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03974-1", "uniprot_id": "TERA_PIG", "mass": 89289.0, "length": 806, "protein_name": "Transitional endoplasmic reticulum ATPase", "gene_name": "VCP", "organism": "Pig", "refseq_name": "transitional endoplasmic reticulum ATPase", "refseq_ac": "NP_999445", "gene_names_uniprotkb": "VCP", "gene_names_refseq": "VCP; p93", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit; 3.6.4.6; TER ATPase; VCP; Valosin-containing protein", "protein_names_refseq": "15S Mg(2+)-ATPase p97 subunit; TER ATPase; transitional endoplasmic reticulum ATPase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397524)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2927256;3468358;4054310", "class_list": "", "function": "Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (By similarity). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Involved in clearance process by mediating G3BP1 extraction from stress granules. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1905634 regulation of protein localization to chromatin;GO:0006281 DNA repair;GO:0016236 macroautophagy;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03974-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04088-1", "uniprot_id": "INHBB_PIG", "mass": 45038.0, "length": 407, "protein_name": "Inhibin beta B chain", "gene_name": "INHBB", "organism": "Pig", "refseq_name": "inhibin beta B chain precursor", "refseq_ac": "NP_001158314", "gene_names_uniprotkb": "INHBB", "gene_names_refseq": "INHBB", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "Inhibin beta B chain; activin beta-B chain; inhibin beta B chain precursor; inhibin beta B subunit; inhibin beta-(b) subunit; inhibin, beta B (activin AB beta polypeptide)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397490)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1644823;17010559;24134883;2417121;24446339", "class_list": "", "function": "Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing. Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A. Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8 (By similarity). Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content (By similarity). Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA (By similarity)., [UniProtKB, UniProtKB]; An increased expression of Inhibin-beta B was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation., [RefSeq, PubMed]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]; Our data indicate that miR-34a plays an important role in granulosa cell apoptosis by targeting the INHBB gene in the porcine ovary Publication Status: Online-Only, [RefSeq, PubMed]; Results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8MIM0", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0032869 cellular response to insulin stimulus;GO:0009611 response to wounding;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04178-1", "uniprot_id": "SODC_PIG", "mass": 15892.0, "length": 153, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "SOD1", "organism": "Pig", "refseq_name": "superoxide dismutase [Cu-Zn]", "refseq_ac": "NP_001177351", "gene_names_uniprotkb": "SOD1", "gene_names_refseq": "SOD1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "Cu-Zn-superoxide dismutase; hydrogen sulfide oxidase; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]", "tax_id": 9823, "disease": "", "pathway": " (ssc:397036); (R-SSC-114608); (R-SSC-3299685)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20943491;23394364;28624353;3891411", "class_list": "", "function": "CuZnSOD mRNA is a broad-spectrum expression gene, which was detected in brain, heart, spleen, liver, kidney, lung, large intestine, small intestine, spinal cord, muscle, backfat, and stomach, [RefSeq, PubMed]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides., [UniProtKB, UniProtKB]; Sequence comparison between sows with high and low estimated breeding value (EBV) for litter size, revealed a total of eight single nucleotide polymorphisms (SNPs) in the noncoding sequence and no SNPs in the coding region., [RefSeq, PubMed]; The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1alpha and increased SOD-2 gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding;GO:0005507 copper ion binding;GO:0030346 protein phosphatase 2B binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0000303 response to superoxide;GO:0007283 spermatogenesis;GO:0007626 locomotory behavior;GO:0040014 regulation of multicellular organism growth;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04366-1", "uniprot_id": "AMBP_PIG", "mass": 37691.0, "length": 337, "protein_name": "Protein AMBP", "gene_name": "AMBP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AMBP; ITIL", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein AMBP; Bikunin; EI-14; HI-30", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1696914;1703444;2408637", "class_list": "", "function": "Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments. Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis. Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential. Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage. Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures. Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation. Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria. Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (By similarity). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Kunitz-type serine protease inhibitor and structural component of extracellular matrix with a role in extracellular space remodeling and cell adhesion. Among others, has antiprotease activity toward kallikrein, a protease involved in airway inflammation; inhibits GZMK/granzyme, a granule-stored serine protease involved in NK and T cell cytotoxic responses; and inhibits PLG/plasmin, a protease required for activation of matrix metalloproteinases. As part of I-alpha-I complex, provides for the heavy chains to be transferred from I-alpha-I complex to hyaluronan in the presence of TNFAIP6, in a dynamic process that releases free bikunin and remodels extracellular matrix proteoglycan structures. Free bikunin, but not its heavy chain-bound form, acts as a potent protease inhibitor in airway secretions (By similarity). Part of hyaluronan-rich extracellular matrix that surrounds oocyte during cumulus oophorus expansion, an indispensable process for proper ovulation (By similarity). Also inhibits calcium oxalate crystallization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P34954", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042803 protein homodimerization activity;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0019862 IgA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04404-1", "uniprot_id": "CMGA_PIG", "mass": 49328.0, "length": 446, "protein_name": "Chromogranin-A", "gene_name": "CHGA", "organism": "Pig", "refseq_name": "chromogranin-A precursor", "refseq_ac": "NP_001157477", "gene_names_uniprotkb": "CHGA", "gene_names_refseq": "CHGA", "protein_names_uniprotkb": "Chromogranin-A; CgA", "protein_names_refseq": "cgA; chromogranin A (parathyroid secretory protein 1); chromogranin-A precursor; pancreastatin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397540)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12826904;2105940;24507880;24752611;2834189;3537810;8344192", "class_list": "", "function": "Expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells, [RefSeq, PubMed]; High pancreastatin levels are significantly associated with neuroendocrine tumors., [RefSeq, PubMed]; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines., [UniProtKB, UniProtKB]; Inhibits low calcium-stimulated parathyroid cell secretion., [UniProtKB]; No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring., [RefSeq, PubMed]; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation., [UniProtKB, UniProtKB]; Strongly inhibits glucose induced insulin release from the pancreas., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030133 transport vesicle;GO:0042583 chromaffin granule", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0046676 negative regulation of insulin secretion;GO:0042742 defense response to bacterium;GO:0045576 mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04761-1", "uniprot_id": "ACM1_PIG", "mass": 51419.0, "length": 460, "protein_name": "Muscarinic acetylcholine receptor M1", "gene_name": "CHRM1", "organism": "Pig", "refseq_name": "muscarinic acetylcholine receptor M1", "refseq_ac": "NP_999199", "gene_names_uniprotkb": "CHRM1", "gene_names_refseq": "CHRM1; mAChR", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M1", "protein_names_refseq": "muscarinic acetylcholine receptor M1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397099); (R-SSC-390648); (R-SSC-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3762692", "class_list": "", "function": "The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0046541 saliva secretion;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05024-1", "uniprot_id": "AT1A1_PIG", "mass": 112681.0, "length": 1021, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-1", "gene_name": "ATP1A1", "organism": "Pig", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-1", "refseq_ac": "NP_999414", "gene_names_uniprotkb": "ATP1A1", "gene_names_refseq": "ATP1A1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-1; 7.2.2.13; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1", "protein_names_refseq": "(Na+, K+)-ATPase alpha-subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na+ /K+ ATPase alpha 1 subunit; Na+/K+ transporting alpha 1 polypeptide; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397481)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "15563542;18075585;23776223;24051246;2423371;25624492;27748508;2844194;29522705;29688626;3032208;31669257;33318128;35380894;35926706;36835408;37357620", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that bufadienolides harbor qualitative chemical differences from cardenolides with respect to the Na(+)/K(+)-ATPase (NKA) conformations to which they can bind., [RefSeq, PubMed]; The Alpha-1 Subunit of the Na[+]/K[+]-ATPase (ATP1A1) Is a Host Factor Involved in the Attachment of Porcine Epidemic Diarrhea Virus. Publication Status: Online-Only, [RefSeq, PubMed]; The extracellular entrance to the binding site on Sodium-Potassium-Exchanging ATPase has been characterized using spin-labeled derivatives of cardiotonic steroids., [RefSeq, PubMed]; The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling., [RefSeq, PubMed]; This study determined the specificity of the interaction between the N-terminus of the alpha-subunit of the Na+,K+-ATPase and the surrounding membrane. Erratum:[Biochim Biophys Acta Biomembr. 2026 Jan;1868(1):184482. doi: 10.1016/j.bbamem.2025.184482. PMID: 41207808], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P18874", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051117 ATPase binding;GO:0016887 ATP hydrolysis activity;GO:0030955 potassium ion binding;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0042470 melanosome", "go_biological_process": "GO:0055085 transmembrane transport;GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis;GO:0010248 establishment or maintenance of transmembrane electrochemical gradient;GO:0030007 intracellular potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P05024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05027-1", "uniprot_id": "AT1B1_PIG", "mass": 35158.0, "length": 303, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1", "gene_name": "ATP1B1", "organism": "Pig", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1", "refseq_ac": "NP_001001542", "gene_names_uniprotkb": "ATP1B1", "gene_names_refseq": "ATP1B1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1", "protein_names_refseq": "ATPase, Na+/K+ transporting, beta 1 polypeptide; Na+, K+-ATPase beta-subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:396898); (R-SSC-5578775); (R-SSC-936837)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19726667;20501797;21182963;2423371;2436627;3036581", "class_list": "", "function": "Involved in cell adhesion and establishing epithelial cell polarity., [UniProtKB, UniProtKB]; Na,K-ATPase is a new target of TGF-beta(1)-mediated Epithelial-to-mesenchymal transition in renal epithelial cells, a model system used in studies of both cancer progression and fibrosis., [RefSeq, PubMed]; Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers conformational changes., [RefSeq, PubMed]; Re-arrangements of the Na+,K+-ATPase stabilized by cardiotonic steroids may affect protein-protein interactions within the intracellular signal transduction networks, [RefSeq, PubMed]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0036126 sperm flagellum;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0045087 innate immune response;GO:0055085 transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P05027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05207-1", "uniprot_id": "KAP2_PIG", "mass": 17706.0, "length": 155, "protein_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "gene_name": "PRKAR2A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRKAR2A", "gene_names_refseq": "", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "225318;2431926", "class_list": "", "function": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex;GO:0042585 germinal vesicle", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation;GO:1904146 positive regulation of meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06867-1", "uniprot_id": "PLMN_PIG", "mass": 90615.0, "length": 809, "protein_name": "Plasminogen", "gene_name": "PLG", "organism": "Pig", "refseq_name": "plasminogen precursor", "refseq_ac": "NP_001038055", "gene_names_uniprotkb": "PLG", "gene_names_refseq": "PLG", "protein_names_uniprotkb": "Plasminogen", "protein_names_refseq": "plasminogen precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:733660)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22177313;3356193;3846533", "class_list": "", "function": "Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A., [UniProtKB, UniProtKB]; Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (By similarity). In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q19AZ9", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0048771 tissue remodeling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07634-1", "uniprot_id": "ANFB_PIG", "mass": 14512.0, "length": 131, "protein_name": "Natriuretic peptides B", "gene_name": "NPPB", "organism": "Pig", "refseq_name": "natriuretic peptides B precursor", "refseq_ac": "NP_999011", "gene_names_uniprotkb": "NPPB", "gene_names_refseq": "BNP1; BNP; Iso-ANP; NPPB", "protein_names_uniprotkb": "Natriuretic peptides B; Brain natriuretic factor prohormone; Gamma-brain natriuretic peptide; Iso-ANP; NT-pro-BNP; NT-proBNP(1-76); preproBNP; proBNP", "protein_names_refseq": "brain natriuretic factor prohormone; gamma-brain natriuretic peptide; natriuretic peptides B precursor; natriuretic peptides B; preproBNP; proBNP", "tax_id": 9823, "disease": "", "pathway": " (ssc:396844)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1915362;2146114;21471537;21958326;23539511;24912131;2708334;2964562;3196347;3196348;32663503;3421965", "class_list": "", "function": "ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations., [RefSeq, PubMed]; CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals, [RefSeq, PubMed]; Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions., [RefSeq, PubMed]; Effect of insulin on natriuretic peptide gene expression in porcine heart., [RefSeq, PubMed]; May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32., [UniProtKB, UniProtKB]; Plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:2964562). In vivo, induces vasodilation (PubMed:2964562)., [UniProtKB, PubMed]; Serum levels predict mortality in chest pain patients in Argentina Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0097746 blood vessel diameter maintenance;GO:0006457 protein folding;GO:0003085 negative regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07802-1", "uniprot_id": "KAP0_PIG", "mass": 42922.0, "length": 380, "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "PRKAR1A", "organism": "Pig", "refseq_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "refseq_ac": "NP_999191", "gene_names_uniprotkb": "PRKAR1A", "gene_names_refseq": "PRKAR1A", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type I regulatory subunit; cAMP-dependent protein kinase type I-alpha regulatory subunit; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397091)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17606608;22674394;3040400;3667618", "class_list": "", "function": "Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate, [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08001-1", "uniprot_id": "ACRO_PIG", "mass": 45362.0, "length": 415, "protein_name": "Acrosin", "gene_name": "ACR", "organism": "Pig", "refseq_name": "acrosin precursor", "refseq_ac": "NP_999198", "gene_names_uniprotkb": "ACR", "gene_names_refseq": "ACR", "protein_names_uniprotkb": "Acrosin; 3.4.21.10; 53 kDa fucose-binding protein", "protein_names_refseq": "53 kDa fucose-binding protein; acrosin precursor; preproacrosin", "tax_id": 9823, "disease": "", "pathway": " (ssc:397098)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "2111146;21871203;2261983;2502391;2745422;3480243;36815564;6378631;7007202;8737992", "class_list": "", "function": "Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome., [UniProtKB]; Characterization of acrosin and acrosin binding protein as novel CRISP2 interacting proteins in boar spermatozoa., [RefSeq, PubMed]; During epididymal maturation of boar sperm, alpha-/beta-acrosin isoform expression increases, reaching maximum in cauda; gamma-acrosin isoform is not expressed. In vitro capacitation leads to relocation of acrosin to apical ridge of sperm head., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P08000;Q29015", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0004040 amidase activity;GO:0005537 D-mannose binding;GO:0042806 fucose binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0043159 acrosomal matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007190 activation of adenylate cyclase activity;GO:0007338 single fertilization;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P08001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08835-1", "uniprot_id": "ALBU_PIG", "mass": 69692.0, "length": 607, "protein_name": "Albumin", "gene_name": "ALB", "organism": "Pig", "refseq_name": "albumin precursor", "refseq_ac": "NP_001005208", "gene_names_uniprotkb": "ALB", "gene_names_refseq": "ALB", "protein_names_uniprotkb": "Albumin", "protein_names_refseq": "albumin precursor; serum albumin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396960)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2728927;3174440", "class_list": "", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29018;Q68NH7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0030170 pyridoxal phosphate binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0009267 cellular response to starvation;GO:0051902 negative regulation of mitochondrial depolarization;GO:0072732 cellular response to calcium ion starvation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08835-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09623-1", "uniprot_id": "DLDH_PIG", "mass": 54185.0, "length": 509, "protein_name": "Dihydrolipoyl dehydrogenase, mitochondrial", "gene_name": "DLD", "organism": "Pig", "refseq_name": "dihydrolipoyl dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_999227", "gene_names_uniprotkb": "DLD; LAD", "gene_names_refseq": "DLDH; DLD", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase, mitochondrial; 1.8.1.4; Dihydrolipoamide dehydrogenase", "protein_names_refseq": "dihydrolipoyl dehydrogenase, mitochondrial precursor; dihydrolipoyl dehydrogenase, mitochondrial; lipoamide dehydrogenase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397129)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17404228;20097961;3693355;6954534", "class_list": "", "function": "Human, mouse, and pig Dld has moonlighting function as a protease in addition to its canonical function as a a dehydrogenase., [RefSeq, PubMed]; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). The pyruvate dehydrogenase (PDH) complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E3 subunit catalyzes reoxidation of the dihydrolipoyl moiety on lipoyl-bearing domains (LBDs) of E2 with NAD+ as the ultimate electron acceptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Lipoamide dehydrogenase significantly accelerates the conversion of a defined subset of NO donors to NO., [RefSeq, PubMed]; This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09858-1", "uniprot_id": "TGFB2_PIG", "mass": 49922.0, "length": 435, "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "TGFB2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta-2 proprotein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2879635", "class_list": "", "function": "Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051891 positive regulation of cardioblast differentiation;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10612-1", "uniprot_id": "CP11A_PIG", "mass": 60258.0, "length": 520, "protein_name": "Cholesterol side-chain cleavage enzyme, mitochondrial", "gene_name": "CYP11A1", "organism": "Pig", "refseq_name": "cholesterol side-chain cleavage enzyme, mitochondrial precursor", "refseq_ac": "NP_999592", "gene_names_uniprotkb": "CYP11A1", "gene_names_refseq": "CYP11A1; SSC", "protein_names_uniprotkb": "Cholesterol side-chain cleavage enzyme, mitochondrial; 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)", "protein_names_refseq": "CYPXIA1; P450 cholesterol side chain cleavage protein; cholesterol desmolase; cholesterol side-chain cleavage enzyme, mitochondrial precursor; cholesterol side-chain cleavage enzyme, mitochondrial; cytochrome P-450 cholesterol side-chain cleavage enzyme; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450, family 11, subfamily A, polypeptide 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:403329); (R-SSC-196108); (R-SSC-211976)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1773895;2039527;22217831;22877869;23580952;27512005;2922297;36074900", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:1773895, PubMed:2039527). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:1773895, PubMed:2039527). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:1773895, PubMed:2039527)., [UniProtKB, PubMed, PubMed]; Data suggest that gonadotropin-induced accumulation of P450scc mRNA results from increased transcription, and that this stimulation, at least in part, is protein synthesis-dependent., [RefSeq, PubMed]; Leptin in elevated doses, by stimulatory effect on CYP11A1 and 17b-HSD protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs., [RefSeq, PubMed]; Lnc2300 is a cis-acting long noncoding RNA of CYP11A1 in ovarian granulosa cells., [RefSeq, PubMed]; Tissues expressing P450scc can metabolize 7-dehydrocholesterol to biologically active 7-dehydropregnenolone., [RefSeq, PubMed]; We have shown, for the first time to our knowledge, the expression of CYP11A1 gene in the porcine endometrium and myometrium during early pregnancy and the oestrous cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006700 C21-steroid hormone biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0034650 cortisol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10669-1", "uniprot_id": "FST_PIG", "mass": 38035.0, "length": 344, "protein_name": "Follistatin", "gene_name": "FST", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FST", "gene_names_refseq": "", "protein_names_uniprotkb": "Follistatin; Activin-binding protein; FS-B; FS", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2473224)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "3120188;3153465;3365249;8340384", "class_list": "", "function": "Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P10670", "ec_number_list": "", "go_molecular_function": "GO:0048185 activin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005730 nucleolus", "go_biological_process": "GO:0030154 cell differentiation;GO:0032926 negative regulation of activin receptor signaling pathway;GO:0030510 regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11483-1", "uniprot_id": "ACM3_PIG", "mass": 66078.0, "length": 590, "protein_name": "Muscarinic acetylcholine receptor M3", "gene_name": "CHRM3", "organism": "Pig", "refseq_name": "muscarinic acetylcholine receptor M3", "refseq_ac": "NP_001116570", "gene_names_uniprotkb": "CHRM3", "gene_names_refseq": "CHRM3", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M3", "protein_names_refseq": "muscarinic acetylcholine receptor M3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144478); (R-SSC-390648); (R-SSC-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18157728;18563417;20133950;3402600", "class_list": "", "function": "Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers., [RefSeq, PubMed]; Expression and function of M2 and M3 receptors are similar in the detrusor of juvenile and mature pigs., [RefSeq, PubMed]; M2 and M3 receptors are upregulated in a time-dependent and pressure-dependent fashion after as little as a 24 h exposure to increased hydrostatic pressure in bladder, [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:0042166 acetylcholine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0045987 positive regulation of smooth muscle contraction;GO:0046541 saliva secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11483-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11936-1", "uniprot_id": "DNAS1_PIG", "mass": 31626.0, "length": 284, "protein_name": "Deoxyribonuclease-1", "gene_name": "DNASE1", "organism": "Pig", "refseq_name": "deoxyribonuclease-1 precursor", "refseq_ac": "NP_999156", "gene_names_uniprotkb": "DNASE1; DNL1", "gene_names_refseq": "DNASE1", "protein_names_uniprotkb": "Deoxyribonuclease-1; 3.1.21.1; DNase I; Deoxyribonuclease I", "protein_names_refseq": "DNase I; deoxyribonuclease I; deoxyribonuclease-1 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397051)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11410284;3782104", "class_list": "", "function": "Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:3782104). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:3782104). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q95KK2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006915 apoptotic process;GO:0006308 DNA catabolic process;GO:0002673 regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14632-1", "uniprot_id": "TRFL_PIG", "mass": 77626.0, "length": 704, "protein_name": "Lactotransferrin", "gene_name": "LTF", "organism": "Pig", "refseq_name": "lactotransferrin precursor", "refseq_ac": "NP_999527", "gene_names_uniprotkb": "LTF", "gene_names_refseq": "LTF; PLF", "protein_names_uniprotkb": "Lactotransferrin; 3.4.21.-; Lactoferrin", "protein_names_refseq": "lactoferrin; lactotransferrin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397649)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1503259;1511016;17489602;20541878;20607309;2605266;27487204", "class_list": "", "function": "Growth performance of animal pups is enhanced by directly feeding the genetically engineered milk containing enriched pLF protein in transgenic mice., [RefSeq, PubMed]; Involvement of HSP27 and lactoferrin in porcine endometrium and neutrophils activity., [RefSeq, PubMed]; Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site., [UniProtKB, UniProtKB]; Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA., [UniProtKB, UniProtKB]; The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites., [UniProtKB, UniProtKB]; This paper shows that recombinant lactoferrin peptide LF-6 produced with intein technology has both antibacterial and immunomodulatory activity in mice, [RefSeq, PubMed]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate., [UniProtKB, UniProtKB]; We propose that lactoferrin functions in the immune defense of the small intestinal mucosa by targeting the population of T cells in the lamina propria, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q29557", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0042581 specific granule", "go_biological_process": "GO:0006508 proteolysis;GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0043066 negative regulation of apoptotic process;GO:0033690 positive regulation of osteoblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P14632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15203-1", "uniprot_id": "TGFB3_PIG", "mass": 46814.0, "length": 409, "protein_name": "Transforming growth factor beta-3 proprotein", "gene_name": "TGFB3", "organism": "Pig", "refseq_name": "transforming growth factor beta-3 proprotein preproprotein", "refseq_ac": "NP_999363", "gene_names_uniprotkb": "TGFB3", "gene_names_refseq": "TGFB3", "protein_names_uniprotkb": "Transforming growth factor beta-3 proprotein", "protein_names_refseq": "TGF-beta-3; transforming growth factor beta-3 proprotein preproprotein; transforming growth factor beta-3 proprotein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397400); (R-SSC-114608); (R-SSC-2129379); (R-SSC-2173789)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "18366004;20378284;3208746", "class_list": "", "function": "In swine, TGF-beta3 mRNA is expressed throughout the oestrus cycle., [RefSeq, PubMed]; Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TGFbeta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in luteinizing pig follicles., [RefSeq, PubMed]; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively., [UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0050431 transforming growth factor beta binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15203-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16293-1", "uniprot_id": "FA9_PIG", "mass": 45516.0, "length": 409, "protein_name": "Coagulation factor IX", "gene_name": "F9", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "F9", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; Christmas factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2303254;3322404;7568220;8856916", "class_list": "", "function": "Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q28994", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16960-1", "uniprot_id": "RYR1_PIG", "mass": 565332.0, "length": 5035, "protein_name": "Ryanodine receptor 1", "gene_name": "RYR1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RYR1; CRC", "gene_names_refseq": "", "protein_names_uniprotkb": "Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1329581;2174405;8288238", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (By similarity). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0042383 sarcolemma;GO:0030018 Z disc;GO:0031090 organelle membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006936 muscle contraction;GO:0051289 protein homotetramerization;GO:0006874 intracellular calcium ion homeostasis;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16960-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17560-1", "uniprot_id": "RENBP_PIG", "mass": 46402.0, "length": 402, "protein_name": "N-acylglucosamine 2-epimerase", "gene_name": "RENBP", "organism": "Pig", "refseq_name": "N-acylglucosamine 2-epimerase", "refseq_ac": "NP_999065", "gene_names_uniprotkb": "RENBP", "gene_names_refseq": "RENBP; RnBP", "protein_names_uniprotkb": "N-acylglucosamine 2-epimerase; 5.1.3.8; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP", "protein_names_refseq": "AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; N-acyl-D-glucosamine 2-epimerase; N-acylglucosamine 2-epimerase", "tax_id": 9823, "disease": "", "pathway": " (ssc:396934); (R-SSC-446210)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11061972;2050686;2182620;8663114", "class_list": "", "function": "Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine (PubMed:8663114). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QAR6;Q95331", "ec_number_list": "", "go_molecular_function": "GO:0050121 N-acylglucosamine 2-epimerase activity;GO:0030414 peptidase inhibitor activity;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17741-1", "uniprot_id": "HMGB2_PIG", "mass": 24133.0, "length": 210, "protein_name": "High mobility group protein B2", "gene_name": "HMGB2", "organism": "Pig", "refseq_name": "high mobility group protein B2", "refseq_ac": "NP_999228", "gene_names_uniprotkb": "HMGB2; HMG2", "gene_names_refseq": "HMG-2; HMG2; HMGB2", "protein_names_uniprotkb": "High mobility group protein B2; HMG-2; High mobility group protein 2", "protein_names_refseq": "high mobility group protein 2; high mobility group protein B2; non-histone protein HMG2", "tax_id": 9823, "disease": "", "pathway": " (ssc:397130); (R-SSC-140342)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11275566;2350545", "class_list": "", "function": "Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11275566). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0003690 double-stranded DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17741-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17803-1", "uniprot_id": "IFNG_PIG", "mass": 19419.0, "length": 166, "protein_name": "Interferon gamma", "gene_name": "IFNG", "organism": "Pig", "refseq_name": "interferon gamma precursor", "refseq_ac": "NP_999113", "gene_names_uniprotkb": "IFNG", "gene_names_refseq": "IFNG", "protein_names_uniprotkb": "Interferon gamma; IFN-gamma", "protein_names_refseq": "IFN-gamma; interferon gamma precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396991); (R-SSC-877300); (R-SSC-877312); (R-SSC-9732724)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12787406;15894119;18164876;1953787;19766617;20567833;2115994;25413352;31385116", "class_list": "", "function": "IFN-gamma plays a crucial role in curtailing enteric coronavirus infection and may serve as an effective prophylactic and/or therapeutic agent against transmissible gastroenteritis virus infection., [RefSeq, PubMed]; IFNgamma production from the frozen peripheral blood mononuclear cells was significantly higher than that from the fresh ones., [RefSeq, PubMed]; Mapping of QTL for mycoplasma and tetanus antibodies and IFNgamma., [RefSeq, PubMed]; Selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases, [RefSeq, PubMed]; The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported., [RefSeq, PubMed]; The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR., [RefSeq, PubMed]; Translational control of IL-18 expression by its 5'-UTR limits production of IL-18, resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8+-mediated macrophage-dependent GN., [RefSeq, PubMed]; Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZP3", "ec_number_list": "", "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0032747 positive regulation of interleukin-23 production;GO:0032700 negative regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P17803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18104-1", "uniprot_id": "ANFC_PIG", "mass": 13243.0, "length": 126, "protein_name": "C-type natriuretic peptide", "gene_name": "NPPC", "organism": "Pig", "refseq_name": "C-type natriuretic peptide precursor", "refseq_ac": "NP_001008482", "gene_names_uniprotkb": "NPPC; CNP", "gene_names_refseq": "CNP; NPPC", "protein_names_uniprotkb": "C-type natriuretic peptide", "protein_names_refseq": "C-type natriuretic peptide precursor; C-type natriuretic peptide; natriuretic peptide precursor C", "tax_id": 9823, "disease": "", "pathway": " (ssc:493772); (R-SSC-5578768)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15231517;18568948;19540894;2139780;2146957;2383278;24373811;24912131", "class_list": "", "function": "CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals., [RefSeq, PubMed]; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibition of restenosis without compromising reendothelialization makes use of gene transfer into endothelial cells and muscle, smooth, vascular cells by administration of CNP., [RefSeq, PubMed]; Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction., [RefSeq, PubMed]; The first intron in the CNP sequence does not contain any additional enhancer-binding sites. However, the signal sequence is indispensable for secretion of CNP and its appropriate physiological function., [RefSeq, PubMed]; The heart is not a major source of circulating proCNP in neonatal piglets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P21806", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035483 gastric emptying;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006182 cGMP biosynthetic process;GO:0001974 blood vessel remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P18104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18648-1", "uniprot_id": "APOA1_PIG", "mass": 30325.0, "length": 265, "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "organism": "Pig", "refseq_name": "apolipoprotein A-I preproprotein", "refseq_ac": "NP_999563", "gene_names_uniprotkb": "APOA1", "gene_names_refseq": "APOA1", "protein_names_uniprotkb": "Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1", "protein_names_refseq": "apo-AI; apoA-I; apolipoprotein A-I preproprotein; apolipoprotein A-I", "tax_id": 9823, "disease": "", "pathway": " (ssc:397691)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15845530;15878672;178359;2105375;25377528;7916724;8294940;8428656;8468059", "class_list": "", "function": "Alterations in the Apo A-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A-I were observed in Salmonella typhimurium and Escherichia coli infections., [RefSeq, PubMed]; Blood level decreases during experimentally induced acute-phase processes in pigs, [RefSeq, PubMed]; Down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 and tumor necrosis factor-alpha, [RefSeq, PubMed]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P18648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18650-1", "uniprot_id": "APOE_PIG", "mass": 36599.0, "length": 317, "protein_name": "Apolipoprotein E", "gene_name": "APOE", "organism": "Pig", "refseq_name": "apolipoprotein E precursor", "refseq_ac": "NP_999473", "gene_names_uniprotkb": "APOE", "gene_names_refseq": "APOE", "protein_names_uniprotkb": "Apolipoprotein E; Apo-E", "protein_names_refseq": "apo-E; apolipoprotein E precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397576)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21549015;7417263;9682450", "class_list": "", "function": "APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells., [UniProtKB, UniProtKB]; These data suggest that the -155T>A mutation in the promoter region of the porcine APOE gene is an important functional variant Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O19099", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0034363 intermediate-density lipoprotein particle;GO:0034364 high-density lipoprotein particle;GO:0070062 extracellular exosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042158 lipoprotein biosynthetic process;GO:0033344 cholesterol efflux;GO:0034380 high-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18871-1", "uniprot_id": "ADA2A_PIG", "mass": 50666.0, "length": 465, "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "ADRA2A", "organism": "Pig", "refseq_name": "alpha-2A adrenergic receptor", "refseq_ac": "NP_999565", "gene_names_uniprotkb": "ADRA2A; A2AR", "gene_names_refseq": "ADRA2A; ADRA2; PORA2AR", "protein_names_uniprotkb": "Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR", "protein_names_refseq": "adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha2A-adrenergic receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:399501); (R-SSC-390696); (R-SSC-392023); (R-SSC-400042); (R-SSC-418594); (R-SSC-418597); (R-SSC-5683826)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "2170371;24801676;8385131", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (Kir6.2, associated with Sur1), glucagon-like peptide 1 receptor (GLP1R), and adrenergic receptor alpha 2A (ADRalpha2A), [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0032795 heterotrimeric G-protein binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0098793 presynapse;GO:0098691 dopaminergic synapse", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19756-1", "uniprot_id": "GHR_PIG", "mass": 71145.0, "length": 638, "protein_name": "Growth hormone receptor", "gene_name": "GHR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth hormone receptor; GH receptor; Serum-binding protein; Somatotropin receptor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2243805;8647880", "class_list": "", "function": "Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (By similarity). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:8647880)., [UniProtKB, PubMed, UniProtKB]; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004903 growth hormone receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0009897 external side of plasma membrane;GO:0070195 growth hormone receptor complex", "go_biological_process": "GO:0006897 endocytosis;GO:0008284 positive regulation of cell population proliferation;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway;GO:0060396 growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20002-1", "uniprot_id": "FGF1_PIG", "mass": 17103.0, "length": 152, "protein_name": "Fibroblast growth factor 1", "gene_name": "FGF1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FGF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor 1; Acidic fibroblast growth factor; ECGF; Endothelial cell growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; aFGF", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1719973;2714282", "class_list": "", "function": "Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20303-1", "uniprot_id": "GTR1_PIG", "mass": 54036.0, "length": 492, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 1", "gene_name": "SLC2A1", "organism": "Pig", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 1", "refseq_ac": "XP_020952567", "gene_names_uniprotkb": "SLC2A1; GLUT1", "gene_names_refseq": "SLC2A1", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 1; GLUT-1; Glucose transporter type 1, erythrocyte/brain", "protein_names_refseq": "solute carrier family 2, facilitated glucose transporter member 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:102164419); (R-SSC-189200); (R-SSC-196836); (R-SSC-422356); (R-SSC-5653890)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "2472815", "class_list": "", "function": "Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "K9IVJ7", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0015150 fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0045494 photoreceptor cell maintenance;GO:0032868 response to insulin;GO:0015911 long-chain fatty acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20305-1", "uniprot_id": "GELS_PIG", "mass": 84775.0, "length": 772, "protein_name": "Gelsolin", "gene_name": "GSN", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GSN", "gene_names_refseq": "", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor; Brevin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-264870); (R-SSC-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2850369;3023087", "class_list": "", "function": "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0060271 cilium assembly;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20735-1", "uniprot_id": "GGT1_PIG", "mass": 61316.0, "length": 568, "protein_name": "Glutathione hydrolase 1 proenzyme", "gene_name": "GGT1", "organism": "Pig", "refseq_name": "glutathione hydrolase 1 proenzyme", "refseq_ac": "NP_999195", "gene_names_uniprotkb": "GGT1; GGT", "gene_names_refseq": "GGT1", "protein_names_uniprotkb": "Glutathione hydrolase 1 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; GGT 1; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; Leukotriene-C4 hydrolase", "protein_names_refseq": "GGT 1; gamma-glutamyl transpeptidase; gamma-glutamyltranspeptidase 1; glutathione hydrolase 1 proenzyme; leukotriene-C4 hydrolase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397095)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10392451;2476308", "class_list": "", "function": "Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A5A784", "ec_number_list": "", "go_molecular_function": "GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0006536 glutamate metabolic process;GO:0002682 regulation of immune system process;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21692-1", "uniprot_id": "MMP1_PIG", "mass": 53666.0, "length": 469, "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "organism": "Pig", "refseq_name": "interstitial collagenase precursor", "refseq_ac": "NP_001159701", "gene_names_uniprotkb": "MMP1", "gene_names_refseq": "MMP1; Mmp1a", "protein_names_uniprotkb": "Interstitial collagenase; 3.4.24.7; MMP-1; Matrix metalloproteinase-1", "protein_names_refseq": "MMP-1; interstitial collagenase precursor; interstitial collagenase; matix metalloproteinase I collagenase propeptide; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloproteinase 1 (type I collagenase); matrix metalloproteinase-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397320); (R-SSC-1442490); (R-SSC-1474228); (R-SSC-1592389)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1651440;18065523;19342253;19639408;2174547;7840605;8590015", "class_list": "", "function": "Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X., [UniProtKB]; Increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1, [RefSeq, PubMed]; Results indicate that leukemia inhibitory factor (LIF) and Oncostatin M increase the expression of MMP-1, MMP-3, and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF antagonist MH35-BD., [RefSeq, PubMed]; The identification of MMP1 and MMP10 genes in swine is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0031334 positive regulation of protein-containing complex assembly;GO:0030574 collagen catabolic process;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P21692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23220-1", "uniprot_id": "AT2B1_PIG", "mass": 134710.0, "length": 1220, "protein_name": "Plasma membrane calcium-transporting ATPase 1", "gene_name": "ATP2B1", "organism": "Pig", "refseq_name": "plasma membrane calcium-transporting ATPase 1", "refseq_ac": "NP_999517", "gene_names_uniprotkb": "ATP2B1", "gene_names_refseq": "ATP2B1", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 1; 7.2.2.10; PMCA1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1", "protein_names_refseq": "plasma membrane Ca2+ pump (PMCA1b); plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397636)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15471573;17606608;20035709;2147100;33704695", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles., [UniProtKB, UniProtKB, UniProtKB]; Ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate, [RefSeq, PubMed]; Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca(2+)-ATPase from basolateral membranes of kidney proximal tubules., [RefSeq, PubMed]; Purified plasma membrane Ca2+ ATPase was able to hydrolyze ATP at a very low rate in the absence of Ca2+., [RefSeq, PubMed]; Results suggest that the activating mechanism of ethanol may involve opening an autoinhibitory domain located close to the calmodulin binding domain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006874 intracellular calcium ion homeostasis;GO:0008217 regulation of blood pressure;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23563-1", "uniprot_id": "TNFA_PIG", "mass": 25254.0, "length": 232, "protein_name": "Tumor necrosis factor", "gene_name": "TNF", "organism": "Pig", "refseq_name": "tumor necrosis factor", "refseq_ac": "NP_999187", "gene_names_uniprotkb": "TNF; TNFA; TNFSF2", "gene_names_refseq": "TNFSF2; TNFa; TNF", "protein_names_uniprotkb": "Tumor necrosis factor; Cachectin; N-terminal fragment; NTF; TNF-alpha; TNF-a; Tumor necrosis factor ligand superfamily member 2", "protein_names_refseq": "TNF-alpha; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397086); (R-SSC-5357786); (R-SSC-5357905); (R-SSC-5357956); (R-SSC-5626978); (R-SSC-5668541); (R-SSC-75893)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "11169259;1874444;2216741;2478420;28683436;30317108;30782567;31213269;34445450", "class_list": "", "function": "Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mechanistically, Porcine productive and respiratory syndrome virus induced an elevated level of tumor necrosis factor (TNF-alpha), through the nuclear factor kappaB (NF-kappaB) signaling pathway to inhibit the replication of classical swine fever virus -C in vitro., [RefSeq, PubMed]; TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes., [RefSeq, PubMed]; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells., [UniProtKB, UniProtKB]; The present study showed that TNF-alpha, which was secreted by the tracheal epithelial cells when they were stimulated with several swine pathogens, damaged tight junction proteins and disrupted the epithelial barrier of a pig tracheal epithelial cell model., [RefSeq, PubMed]; This study shows of TNF-alpha to the form of post-traumatic osteoarthritis induced by 'idealized' anterior cruciate ligament reconstruction in a porcine model, [RefSeq, PubMed]; Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5D9N8", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0000976 transcription cis-regulatory region binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0045121 membrane raft;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:2000866 positive regulation of estradiol secretion;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0060252 positive regulation of glial cell proliferation;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23563-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23695-1", "uniprot_id": "IGF2_PIG", "mass": 20313.0, "length": 181, "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "organism": "Pig", "refseq_name": "insulin-like growth factor 2 preproprotein", "refseq_ac": "NP_999048", "gene_names_uniprotkb": "IGF2; IGF-2", "gene_names_refseq": "IGF-II; IGF2", "protein_names_uniprotkb": "Insulin-like growth factor 2; IGF-II; Insulin-like growth factor II", "protein_names_refseq": "insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2 preproprotein; insulin-like growth factor II; preptin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396916); (R-SSC-114608); (R-SSC-2404192); (R-SSC-2428928); (R-SSC-2428933); (R-SSC-381426)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "12140686;14574411;2243790;27716032;2809477;30259067;30488155;31393967;37107630", "class_list": "", "function": "IGF2 May Enhance Placental Fatty Acid Metabolism by Regulating Expression of Fatty Acid Carriers in the Growth of Fetus and Placenta during Late Pregnancy in Pigs. Publication Status: Online-Only, [RefSeq, PubMed]; IGF2:g.3072G>A polymorphism plays an important role in the regulation of IGF2 gene expression and can be involved in the fatty acid composition in adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Our study confirmed the important effect of a mutation in the ZBED6 binding site motif on IGF2 expression and myogenesis, thus providing the basis for breeding a new line of Liang Guang Small Spotted pigs with improved lean meat percentage, a trait of great commercial value to pig producers., [RefSeq, PubMed]; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3., [UniProtKB, UniProtKB, UniProtKB]; The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results indicated that editing IGF2 intron 3-3072 site using CRISPR-Cas9 technology improved meat production in Bama pigs., [RefSeq, PubMed]; Trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26042-1", "uniprot_id": "MOES_PIG", "mass": 67661.0, "length": 577, "protein_name": "Moesin", "gene_name": "MSN", "organism": "Pig", "refseq_name": "moesin", "refseq_ac": "NP_001009578", "gene_names_uniprotkb": "MSN", "gene_names_refseq": "MSN", "protein_names_uniprotkb": "Moesin; Membrane-organizing extension spike protein", "protein_names_refseq": "membrane-organizing extension spike protein; moesin", "tax_id": 9823, "disease": "", "pathway": " (ssc:494458)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8268231", "class_list": "", "function": "Probably involved in connections of major cytoskeletal structures to the plasma membrane. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0008360 regulation of cell shape;GO:0072678 T cell migration;GO:0001771 immunological synapse formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26044-1", "uniprot_id": "RADI_PIG", "mass": 68550.0, "length": 583, "protein_name": "Radixin", "gene_name": "RDX", "organism": "Pig", "refseq_name": "radixin", "refseq_ac": "NP_001009576", "gene_names_uniprotkb": "RDX", "gene_names_refseq": "RDX", "protein_names_uniprotkb": "Radixin; Moesin-B", "protein_names_refseq": "moesin B; radixin", "tax_id": 9823, "disease": "", "pathway": " (ssc:494457)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8268231", "class_list": "", "function": "Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0030175 filopodium", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0008360 regulation of cell shape;GO:0051693 actin filament capping;GO:2000643 positive regulation of early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27594-1", "uniprot_id": "MX1_PIG", "mass": 75587.0, "length": 663, "protein_name": "Interferon-induced GTP-binding protein Mx1", "gene_name": "MX1", "organism": "Pig", "refseq_name": "interferon-induced GTP-binding protein Mx1", "refseq_ac": "NP_999226", "gene_names_uniprotkb": "MX1", "gene_names_refseq": "MX1; MxA; Mx", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx1; Myxoma resistance protein 1; Myxovirus resistance protein 1", "protein_names_refseq": "interferon-induced GTP-binding protein Mx1 pseudogene; interferon-induced GTP-binding protein Mx1; myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; myxovirus protein; myxovirus resistance protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397128)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1578186;16738935;17203407;18062906;19109387;20167191;25153459;26047650;26095790;26711047", "class_list": "", "function": "Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles., [UniProtKB, PubMed]; Overexpression of porcine Mx1 induce a robust immune response against foot-and-mouth disease virus., [RefSeq, PubMed]; Studied the effects of porcine Mx1 protein on FMDV and BVDV replication by measuring viral reverse transcriptase activity at various time intervals., [RefSeq, PubMed]; The 11-bp deletion Mx1 mutant is lacking antiviral activity able to contribute to the interference of influenza virus replication., [RefSeq, PubMed]; The SINE insertion polymorphism at site -547 of the MX1 gene promoter region is a potential DNA marker for porcine reproductive and respiratory syndrome resistance, [RefSeq, PubMed]; The deletion/insertion polymorphism in exon 14 of the Mx1 gene, which causes a frame shift, showed no significant association with growth or viremia after PRRSV infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1AHC4;Q75PY7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0016197 endosomal transport;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P27594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29797-1", "uniprot_id": "GNAS_PIG", "mass": 46477.0, "length": 397, "protein_name": "Guanine nucleotide-binding protein G(s) subunit alpha", "gene_name": "GNAS", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GNAS", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(s) subunit alpha; Adenylate cyclase-stimulating G alpha protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P29797-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30034-1", "uniprot_id": "PLF4_PIG", "mass": 9644.0, "length": 90, "protein_name": "Platelet factor 4", "gene_name": "PF4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PF4; CXCL4; SCYB4", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet factor 4; C-X-C motif chemokine 4; PF-4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1788836;7737160", "class_list": "", "function": "Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30555-1", "uniprot_id": "AGTR1_PIG", "mass": 40907.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor", "gene_name": "AGTR1", "organism": "Pig", "refseq_name": "type-1 angiotensin II receptor", "refseq_ac": "XP_003132517", "gene_names_uniprotkb": "AGTR1", "gene_names_refseq": "AGTR1; AT1", "protein_names_uniprotkb": "Type-1 angiotensin II receptor; AT1 receptor; Angiotensin II type-1 receptor", "protein_names_refseq": "AT1 receptor; Angiotensin II type-1 receptor; type-1 angiotensin II receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:100519976); (R-SSC-375276); (R-SSC-416476); (R-SSC-8856825); (R-SSC-8856828)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "8491254", "class_list": "", "function": "Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:8491254). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031711 bradykinin receptor binding;GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0001822 kidney development;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30930-1", "uniprot_id": "LCAT_PIG", "mass": 21238.0, "length": 188, "protein_name": "Phosphatidylcholine-sterol acyltransferase", "gene_name": "LCAT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LCAT", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylcholine-sterol acyltransferase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2.3.1.43; 3.1.1.47; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; Phospholipid-cholesterol acyltransferase; Platelet-activating factor acetylhydrolase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2591200;3827927;8820107", "class_list": "", "function": "Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32394-1", "uniprot_id": "HMOX1_PIG", "mass": 33074.0, "length": 288, "protein_name": "Heme oxygenase 1", "gene_name": "HMOX1", "organism": "Pig", "refseq_name": "heme oxygenase 1", "refseq_ac": "NP_001004027", "gene_names_uniprotkb": "HMOX1", "gene_names_refseq": "HMOX1; HSP32", "protein_names_uniprotkb": "Heme oxygenase 1; 1.14.14.18; HO-1", "protein_names_refseq": "HO-1; heat shock protein 32; heme oxygenase (decycling) 1; heme oxygenase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:445512); (R-SSC-189483); (R-SSC-917937); (R-SSC-9609523); (R-SSC-9707564); (R-SSC-9707587)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "1288499;15681702;16333987;23936023;25583855;26471299;27908781;96115", "class_list": "", "function": "Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron., [UniProtKB, UniProtKB, PubMed]; Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor., [RefSeq, PubMed]; Down-regulation of HO-1 is associated with pulmonary arterial hypertension and right ventricular failure. Publication Status: Online-Only, [RefSeq, PubMed]; Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression., [RefSeq, PubMed]; Findings collectively suggest that miR-506 acts as a tumor suppressor via regulation of ROCK1 expression and may thus be a promising therapeutic target for HCC, [RefSeq, PubMed]; Obalt protoporphyrin prevents postictal cerebral vascular dysfunction by upregulating HO-1., [RefSeq, PubMed]; These results provide a unique insight into the molecular mechanisms underlying the antiviral effects of the stress-responsive protein HO-1 during Porcine reproductive and respiratory syndrome virus infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002246 wound healing involved in inflammatory response;GO:0006979 response to oxidative stress;GO:0035094 response to nicotine;GO:0006879 intracellular iron ion homeostasis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32394-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34935-1", "uniprot_id": "BIP_PIG", "mass": 28912.0, "length": 262, "protein_name": "Endoplasmic reticulum chaperone BiP", "gene_name": "HSPA5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPA5; GRP78", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoplasmic reticulum chaperone BiP; 3.6.4.10; 78 kDa glucose-regulated protein; BiP; Binding-immunoglobulin protein; GRP-78; HSP70 family protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3360780", "class_list": "", "function": "Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0031333 negative regulation of protein-containing complex assembly;GO:0031204 post-translational protein targeting to membrane, translocation;GO:1903895 negative regulation of IRE1-mediated unfolded protein response;GO:0035437 maintenance of protein localization in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35054-1", "uniprot_id": "TGBR3_PIG", "mass": 93005.0, "length": 848, "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "TGFBR3", "organism": "Pig", "refseq_name": "transforming growth factor beta receptor type 3 isoform 1 precursor", "refseq_ac": "NP_999437", "gene_names_uniprotkb": "TGFBR3", "gene_names_refseq": "TGFBR3", "protein_names_uniprotkb": "Transforming growth factor beta receptor type 3; Betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III", "protein_names_refseq": "TGF-beta receptor type 3; TGF-beta receptor type III; TGF-beta type III receptor; TGFR-3; betaglycan; transforming growth factor beta receptor III; transforming growth factor beta receptor type 3 isoform 1 precursor; transforming growth factor beta receptor type 3 pseudogene; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor-beta type III receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397512)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1333192;26097017", "class_list": "", "function": "Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (By similarity). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study provides evidence that the expressions of inhibin alpha subunit and betaglycan are inferior in cystic follicles, and this may be caused by the decrease in FSH in the presence of a cystic follicle., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 6, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0015026 coreceptor activity;GO:0005160 transforming growth factor beta receptor binding;GO:0005024 transforming growth factor beta receptor activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006955 immune response;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35495-1", "uniprot_id": "PSP1_PIG", "mass": 14501.0, "length": 133, "protein_name": "Major seminal plasma glycoprotein PSP-I", "gene_name": "", "organism": "Pig", "refseq_name": "major seminal plasma glycoprotein PSP-I precursor", "refseq_ac": "NP_999002", "gene_names_uniprotkb": "", "gene_names_refseq": "PSP-I", "protein_names_uniprotkb": "Major seminal plasma glycoprotein PSP-I; SP3", "protein_names_refseq": "SP3; major seminal plasma glycoprotein PSP-I precursor; major seminal plasma glycoprotein PSP-I", "tax_id": 9823, "disease": "", "pathway": " (ssc:396818)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10504403;1586165;16809275;16819821;17651403;19948361;31280183;7781775;8269963;8397818;8603690;9334740", "class_list": "", "function": "Ability of two fertility-related genomic markers (porcine seminal protein (PSP)-I and PSP-II) in spermatozoa to predict boar litter size in addition to conventional semen parameters., [RefSeq, PubMed]; Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation., [UniProtKB]; PSP-I/PSP-II heterodimer in seminal plasma has a predominant role in triggering the recruitment of uterine polymorphonuclear neutrophils and T cells after mating, initiating a cascade of transient and long-lasting immunological events., [RefSeq, PubMed]; Results indicate that the seminal vesicles are the main source of PSP-I and PSP-II spermadhesins, although epididymal segments, testis and the bulbourethral gland also participate in the expression of both proteins, [RefSeq, PubMed]; The modulation of the structural organization and heparin-binding ability of PSP-I by Zn2+ might be a physiological phenomenon in seminal plasma., [RefSeq, PubMed]; The protective effect of the PSP-I/PSP-II heterodimer in spermatozoa appears to be related to its adhesion to the acrosomal area, and the loss of this protective effect coincides with a stepwise redistribution of PSP-I/PSP-II during incubation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 35, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 68, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 8.2, "record_id": "P35495-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35750-1", "uniprot_id": "CAN1_PIG", "mass": 81739.0, "length": 714, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "CAPN1", "organism": "Pig", "refseq_name": "calpain-1 catalytic subunit", "refseq_ac": "NP_001335713", "gene_names_uniprotkb": "CAPN1", "gene_names_refseq": "CANP 1; CANP; CAPN1", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; CANP 1; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP", "protein_names_refseq": "calcium activated neutral protease; calcium-activated neutral proteinase 1; calpain 1 large subunit; calpain mu-type; calpain-1 catalytic subunit; micromolar calcium-activated neutral protease 1; micromolar-calpain", "tax_id": 9823, "disease": "", "pathway": " (ssc:397027); (R-SSC-1474228); (R-SSC-6798695); (R-SSC-6809371)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11219468;18068185;18501725;18550497;19130893;21450414;8312396;8672129", "class_list": "", "function": "Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage., [RefSeq, PubMed]; CAPN1 HM535412:g.157T > C showed effect on meat redness., [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7)., [UniProtKB, UniProtKB]; Catalytic site amino acid residues 105-133 contained a disulfide bond between Cys(108) and Cys(115), [RefSeq, PubMed]; Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction., [RefSeq, PubMed]; The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29600;Q9N0M6", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0050790 regulation of catalytic activity;GO:0097264 self proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36887-1", "uniprot_id": "KAPCA_PIG", "mass": 40617.0, "length": 351, "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha", "gene_name": "PRKACA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRKACA", "gene_names_refseq": "", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit alpha; 2.7.11.11; PKA C-alpha", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "10684253;2441988;8443157;9521123", "class_list": "", "function": "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (By similarity). Acts as a key inhibitor of smoothened signaling pathway by mediating phosphorylation of GLI (GLI1, GLI2 and GLI3) transcription factors in absence of hedgehog (DHH, IHH or SHH) morphogens: GLI phosphorylation promotes their processing and prevents transcriptional activation of smoothened target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Also inhibits the smoothened signaling pathway in embryonic development by catalyzing phosphorylation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. Phosphorylates AKAP19 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0034605 cellular response to heat;GO:1904262 negative regulation of TORC1 signaling;GO:1904145 negative regulation of meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37176-1", "uniprot_id": "EGLN_PIG", "mass": 70280.0, "length": 653, "protein_name": "Endoglin", "gene_name": "ENG", "organism": "Pig", "refseq_name": "endoglin precursor", "refseq_ac": "NP_999196", "gene_names_uniprotkb": "ENG", "gene_names_refseq": "ENG", "protein_names_uniprotkb": "Endoglin", "protein_names_refseq": "endoglin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397096)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8294451", "class_list": "", "function": "Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005114 type II transforming growth factor beta receptor binding;GO:0005539 glycosaminoglycan binding;GO:0034713 type I transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007155 cell adhesion;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P37176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38551-1", "uniprot_id": "TGFR2_PIG", "mass": 33302.0, "length": 297, "protein_name": "TGF-beta receptor type-2", "gene_name": "TGFBR2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFBR2", "gene_names_refseq": "", "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; TbetaR-II; Transforming growth factor-beta receptor type II", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1310899", "class_list": "", "function": "Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005024 transforming growth factor beta receptor activity;GO:0016361 activin receptor activity, type I;GO:0048185 activin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0048179 activin receptor complex", "go_biological_process": "GO:0007399 nervous system development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38551-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41535-1", "uniprot_id": "PACA_PIG", "mass": 19523.0, "length": 176, "protein_name": "Pituitary adenylate cyclase-activating polypeptide", "gene_name": "ADCYAP1", "organism": "Pig", "refseq_name": "pituitary adenylate cyclase-activating polypeptide precursor", "refseq_ac": "NP_001001544", "gene_names_uniprotkb": "ADCYAP1", "gene_names_refseq": "ADCYAP1; PACAP", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide; PACAP; PRP-48", "protein_names_refseq": "adenylate cyclase activating peptide, pituitary 1; pituitary adenylate cyclase-activating polypeptide precursor; pituitary adenylate cyclase-activating polypeptide", "tax_id": 9823, "disease": "", "pathway": " (ssc:414283)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24713103", "class_list": "", "function": "High level of co-expression of PACAP with VIP, SP and CGRP in the distal ganglia of the vagus sensory perikarya directly implicates studied peptides in their functional interaction during nociceptive vagal transduction., [RefSeq, PubMed]; PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97570;Q6KBX3", "ec_number_list": "", "go_molecular_function": "GO:0016521 pituitary adenylate cyclase activating polypeptide activity;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043204 perikaryon;GO:0043005 neuron projection", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P41535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42098-1", "uniprot_id": "ZP3_PIG", "mass": 46239.0, "length": 421, "protein_name": "Zona pellucida sperm-binding protein 3", "gene_name": "ZP3", "organism": "Pig", "refseq_name": "zona pellucida sperm-binding protein 3 precursor", "refseq_ac": "NP_999058", "gene_names_uniprotkb": "ZP3; ZP3B; ZPC", "gene_names_refseq": "ZP3; ZPC; Zp-3", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3; Sperm receptor; Zona pellucida glycoprotein 3-beta; Zona pellucida glycoprotein 3; Zona pellucida protein C; Zp-3-beta; Zp-3; Zp3-beta", "protein_names_refseq": "sperm receptor; zona pellucida glycoprotein 3-beta; zona pellucida glycoprotein ZP3-beta; zona pellucida protein 3-beta; zona pellucida protein C; zona pellucida sperm-binding protein 3 precursor; zona pellucida sperm-binding protein 3; zp-3-beta; zp3-beta", "tax_id": 9823, "disease": "", "pathway": " (ssc:396927)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10091584;11114588;12878193;1418987;1551388;17550356;21295838;7841460;8562067", "class_list": "", "function": "A study of single nucleotide polymorphisms (SNP) and their relationship to sow reproductive traits in different swine breeds is reported., [RefSeq, PubMed]; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm-binding activity by itself but may increase sperm-binding activity of ZPB., [UniProtKB]; The expression of zona pellucida glycoprotein 3 and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:2000386 positive regulation of ovarian follicle development;GO:0035803 egg coat formation;GO:0007339 binding of sperm to zona pellucida;GO:0002455 humoral immune response mediated by circulating immunoglobulin", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P42098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42099-1", "uniprot_id": "ZP2_PIG", "mass": 79728.0, "length": 716, "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "ZP2", "organism": "Pig", "refseq_name": "zona pellucida sperm-binding protein 2 precursor", "refseq_ac": "NP_999013", "gene_names_uniprotkb": "ZP2; ZPA", "gene_names_refseq": "ZP2; ZPA; Zp-2; pZP1", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 2; Zona pellucida glycoprotein 2; Zona pellucida protein A; Zp-2; pZP1", "protein_names_refseq": "ZP1; Zona pellucida sperm-binding protein 2; zona pellucida 2 glycoprotein; zona pellucida glycoprotein ZP2; zona pellucida protein A; zona pellucida sperm-binding protein 2 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396846); (R-SSC-2534343)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7864874", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005771 multivesicular body;GO:0035805 egg coat", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42174-1", "uniprot_id": "DHE3_PIG", "mass": 61308.0, "length": 558, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "GLUD1", "organism": "Pig", "refseq_name": "glutamate dehydrogenase 1, mitochondrial", "refseq_ac": "NP_001231430", "gene_names_uniprotkb": "GLUD1; GLUD", "gene_names_refseq": "GLUD1; GLUD; MP50", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3; GDH 1; MP50; Membrane protein 50", "protein_names_refseq": "GDH 1; Membrane protein 50; glutamate dehydrogenase 1, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157162); (R-SSC-2151201); (R-SSC-8964539); (R-SSC-9837999)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8240242", "class_list": "", "function": "Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004352 glutamate dehydrogenase (NAD+) activity;GO:0004353 glutamate dehydrogenase [NAD(P)+] activity;GO:0004354 glutamate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006541 glutamine metabolic process;GO:0006538 L-glutamate catabolic process;GO:0072350 tricarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42831-1", "uniprot_id": "CCL2_PIG", "mass": 10976.0, "length": 99, "protein_name": "C-C motif chemokine 2", "gene_name": "CCL2", "organism": "Pig", "refseq_name": "C-C motif chemokine 2 precursor", "refseq_ac": "NP_999379", "gene_names_uniprotkb": "CCL2; SCYA2", "gene_names_refseq": "CCL2; MCP-1", "protein_names_uniprotkb": "C-C motif chemokine 2; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; Small-inducible cytokine A2", "protein_names_refseq": "C-C motif chemokine 2 precursor; C-C motif chemokine 2; monocyte chemoattractant protein 1; monocyte chemotactic protein 1; small-inducible cytokine A2", "tax_id": 9823, "disease": "", "pathway": " (ssc:397422); (R-SSC-380108)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14962280;15274157;16926016;19730125;20580034;20670605;24083897;29278679;7510962", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate. Publication Status: Online-Only, [RefSeq, PubMed]; Contrast media did not affect bone marrow cell viability/MCP-1 secretion., [RefSeq, PubMed]; MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment, [RefSeq, PubMed]; May contribute to xenograft rejection by attracting monocytes into the islets, [RefSeq, PubMed]; Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein., [RefSeq, PubMed]; Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern., [RefSeq, PubMed]; The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling., [RefSeq, PubMed]; These results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P42831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43368-1", "uniprot_id": "CAN3_PIG", "mass": 94551.0, "length": 821, "protein_name": "Calpain-3", "gene_name": "CAPN3", "organism": "Pig", "refseq_name": "calpain-3", "refseq_ac": "NP_999336", "gene_names_uniprotkb": "CAPN3; NCL1", "gene_names_refseq": "CAPN3; SKM; p94", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54; CANP 3; Calcium-activated neutral proteinase 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1", "protein_names_refseq": "CANP 3; calcium-activated neutral proteinase 3; calpain L3; calpain large polypeptide L3; calpain p94; calpain-3; muscle-specific calcium-activated neutral protease 3; nCL-1; new calpain 1; skeletal muscle calpain; skeletal muscle-specific calpain", "tax_id": 9823, "disease": "", "pathway": " (ssc:397349)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21450414;8833248", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB]; The higher CAPN3 gene expression in less tender muscles confirmed the lack of a direct involvement of calpain 3 in meat tenderization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46596;Q28961", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0003824 catalytic activity;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0045892 negative regulation of DNA-templated transcription;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45845-1", "uniprot_id": "LYOX_PIG", "mass": 29073.0, "length": 249, "protein_name": "Protein-lysine 6-oxidase", "gene_name": "LOX", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-lysine 6-oxidase; 1.4.3.13; Lysyl oxidase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7864821;8100985", "class_list": "", "function": "Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7M3F0", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0048514 blood vessel morphogenesis;GO:0018057 peptidyl-lysine oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P45845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45846-1", "uniprot_id": "DERM_PIG", "mass": 21994.0, "length": 183, "protein_name": "Dermatopontin", "gene_name": "DPT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DPT", "gene_names_refseq": "", "protein_names_uniprotkb": "Dermatopontin; 22 kDa extracellular matrix protein; Dermatan sulfate proteoglycan-associated protein 22K; TRAMP; Tyrosine-rich acidic matrix protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "8082810;8100985;8103522", "class_list": "", "function": "Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation (By similarity). Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P45846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46410-1", "uniprot_id": "GLNA_PIG", "mass": 42030.0, "length": 373, "protein_name": "Glutamine synthetase", "gene_name": "GLUL", "organism": "Pig", "refseq_name": "glutamine synthetase", "refseq_ac": "NP_999074", "gene_names_uniprotkb": "GLUL; GLNS", "gene_names_refseq": "GLUL", "protein_names_uniprotkb": "Glutamine synthetase; 2.3.1.225; 6.3.1.2; GS; Glutamate--ammonia ligase; Palmitoyltransferase GLUL", "protein_names_refseq": "GS; glutamate decarboxylase; glutamine synthetase; palmitoyltransferase GLUL", "tax_id": 9823, "disease": "", "pathway": " (ssc:396944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18354250", "class_list": "", "function": "Data show that glutamine synthetase (GS)protein was preferentially expressed in hepatocytes adjacent to oxygen-supplying capillaries and in previously CPS-positive hepatocytes., [RefSeq, PubMed]; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (By similarity). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0045648 positive regulation of erythrocyte differentiation;GO:0097275 intracellular ammonium homeostasis;GO:1903670 regulation of sprouting angiogenesis;GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47787-1", "uniprot_id": "THAS_PIG", "mass": 60485.0, "length": 534, "protein_name": "Thromboxane-A synthase", "gene_name": "TBXAS1", "organism": "Pig", "refseq_name": "thromboxane-A synthase", "refseq_ac": "NP_999211", "gene_names_uniprotkb": "TBXAS1; CYP5A1; CYP5", "gene_names_refseq": "CYP5A1; CYP5; TBXAS1", "protein_names_uniprotkb": "Thromboxane-A synthase; 4.2.1.152; 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; TXA synthase; TXS", "protein_names_refseq": "TXA synthase; TXS; cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); thromboxane-A synthase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397112); (R-SSC-211979); (R-SSC-2162123)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "3745158;8144035", "class_list": "", "function": "Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:3745158). Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004796 thromboxane-A synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48762-1", "uniprot_id": "SL9A1_PIG", "mass": 90987.0, "length": 818, "protein_name": "Sodium/hydrogen exchanger 1", "gene_name": "SLC9A1", "organism": "Pig", "refseq_name": "sodium/hydrogen exchanger 1", "refseq_ac": "NP_001007104", "gene_names_uniprotkb": "SLC9A1; NHE1", "gene_names_refseq": "NHE1; SLC9A1", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 1; NHE-1; Na(+)/H(+) exchanger 1; Solute carrier family 9 member 1", "protein_names_refseq": "NA(+)-H+ exchanger protein; NHE-1; Na(+)/H(+) exchanger 1; sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397458)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1661081;19023020;24376615;34353852", "class_list": "", "function": "Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes., [RefSeq, PubMed]; Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; NHE isoform switching and KChIP2 upregulation takes place in aging porcine atria. Publication Status: Online-Only, [RefSeq, PubMed]; NHE-1 inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0010447 response to acidic pH;GO:0036376 sodium ion export across plasma membrane;GO:0051453 regulation of intracellular pH;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48819-1", "uniprot_id": "VTNC_PIG", "mass": 52572.0, "length": 459, "protein_name": "Vitronectin", "gene_name": "VTN", "organism": "Pig", "refseq_name": "vitronectin precursor", "refseq_ac": "NP_999269", "gene_names_uniprotkb": "VTN", "gene_names_refseq": "VN; VTN", "protein_names_uniprotkb": "Vitronectin; S-protein; Serum-spreading factor; VN", "protein_names_refseq": "S-protein; serum-spreading factor; vitronectin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397192); (R-SSC-2129379); (R-SSC-216083); (R-SSC-3000170); (R-SSC-3000178); (R-SSC-977606)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "1372829;18615592;7506656;8982862", "class_list": "", "function": "For intact vitronectin the effect of the heparin-binding domain predominates with respect to the signaling events that occur following ligand binding to the alphaVbeta3 integrin, [RefSeq, PubMed]; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 16, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 28, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0005044 scavenger receptor activity;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006955 immune response;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P48819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49151-1", "uniprot_id": "VEGFA_PIG", "mass": 22368.0, "length": 190, "protein_name": "Vascular endothelial growth factor A", "gene_name": "VEGFA", "organism": "Pig", "refseq_name": "vascular endothelial growth factor A isoform 1 precursor", "refseq_ac": "NP_999249", "gene_names_uniprotkb": "VEGFA; VEGF", "gene_names_refseq": "VEGFA; VEGF", "protein_names_uniprotkb": "Vascular endothelial growth factor A; VEGF-A; VPF; Vascular permeability factor", "protein_names_refseq": "VEGF-A; VPF; vascular endothelial growth factor A isoform 1 precursor; vascular permeability factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397157)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14998908;15274157;15537448;16333987;28257866;29991364;32905904;33255323;33467052;7841203", "class_list": "", "function": "Contrast media did not affect bone marrow cell viability/VEGF secretion., [RefSeq, PubMed]; Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor., [RefSeq, PubMed]; Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibition of ssc-microRNA-140-5p ameliorates the Clostridium perfringens beta2 toxin-induced inflammatory response in IPEC-J2 cells via the ERK1/2 and JNK pathways by targeting VEGFA., [RefSeq, PubMed]; MMP9 and VEGF, but not MMP13 or FGF23 may have roles in bone lesions in the hypovitaminosis D kyphotic pig model, [RefSeq, PubMed]; Results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility, [RefSeq, PubMed]; The Influence of Melatonin and Light on VEGF Secretion in Primary RPE Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The earlier increase in VEGF protein and mRNA expression in the Meishan versus the Yorkshire conceptus may explain the previously reported increased vascularity and increased placental efficiency of this breed compared the Yorkshire breed., [RefSeq, PubMed]; VEGF upregulation in the proliferative zone after ischemic damage may play a role in stimulating vascular invasion and granulation tissue formation in the necrotic hypertrophic zone of the epiphyseal cartilage, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9GL52", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0097475 motor neuron migration;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P49151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49811-1", "uniprot_id": "MYOD1_PIG", "mass": 34243.0, "length": 319, "protein_name": "Myoblast determination protein 1", "gene_name": "MYOD1", "organism": "Pig", "refseq_name": "myoblast determination protein 1", "refseq_ac": "NP_001002824", "gene_names_uniprotkb": "MYOD1; MYOD", "gene_names_refseq": "MUF3; MYF-3; MYOD1; MYOD", "protein_names_uniprotkb": "Myoblast determination protein 1", "protein_names_refseq": "eukaryotic myogenic factor MYF-3; myoblast determination protein 1; myogenic factor 3; myogenic regulatory factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:407604)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25966141;26944559;32121115;34943981;37506369;7559997", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity)., [UniProtKB]; An Enhancer box and a binding site for a cooperative co-activator of MyoD are present in the promoter region of porcine PPARgamma., [RefSeq, PubMed]; Long Non-Coding RNA H19 Promotes Porcine Satellite Cell Differentiation by Interacting with TDP43. Publication Status: Online-Only, [RefSeq, PubMed]; MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST., [RefSeq, PubMed]; Of the eight adult pig tissue types that were tested, the expression of Myf5 and MyoD1 was highest in the muscle tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Tributyrin, a Butyrate Pro-Drug, Primes Satellite Cells for Differentiation by Altering the Epigenetic Landscape. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007518 myoblast fate determination;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49811-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49923-1", "uniprot_id": "LIPL_PIG", "mass": 53455.0, "length": 478, "protein_name": "Lipoprotein lipase", "gene_name": "LPL", "organism": "Pig", "refseq_name": "lipoprotein lipase precursor", "refseq_ac": "NP_999451", "gene_names_uniprotkb": "LPL", "gene_names_refseq": "LPL", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1", "protein_names_refseq": "lipoprotein lipase precursor; phospholipase A1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397537)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1362860", "class_list": "", "function": "Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0009749 response to glucose;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50118-1", "uniprot_id": "MOS_PIG", "mass": 37941.0, "length": 345, "protein_name": "Proto-oncogene serine/threonine-protein kinase mos", "gene_name": "MOS", "organism": "Pig", "refseq_name": "proto-oncogene serine/threonine-protein kinase mos", "refseq_ac": "NP_001106690", "gene_names_uniprotkb": "MOS", "gene_names_refseq": "MOS; c-mos; p39-mos", "protein_names_uniprotkb": "Proto-oncogene serine/threonine-protein kinase mos; 2.7.11.1; Oocyte maturation factor mos; Proto-oncogene c-Mos", "protein_names_refseq": "oocyte maturation factor mos; proto-oncogene c-Mos; proto-oncogene serine/threonine-protein kinase mos; v-mos Moloney murine sarcoma viral oncogene homolog", "tax_id": 9823, "disease": "", "pathway": " (ssc:100127484)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15987821;8858597", "class_list": "", "function": "Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation., [UniProtKB, UniProtKB]; The length of the MOS 3'-UTR tightly controls the level of translation during oocyte maturation. two U-rich (U5A) elements and the hexanucleotide signal (AAUAAA) are required for translation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0000165 MAPK cascade;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50441-1", "uniprot_id": "GATM_PIG", "mass": 48360.0, "length": 423, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "GATM", "organism": "Pig", "refseq_name": "glycine amidinotransferase, mitochondrial", "refseq_ac": "NP_001121914", "gene_names_uniprotkb": "GATM; AGAT", "gene_names_refseq": "AGAT; GATM", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "L-arginine:glycine amidinotransferase; Transamidinase; glycine amidinotransferase, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:100126844); (R-SSC-71288)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17660697;8313955", "class_list": "", "function": "For the GATM BseLI polymorphism, the Yorkshire and Duroc breeds have higher allele frequencies at the G allele, whereas the local pigs have higher allele frequencies at the A allele. (GATM; glycine amidinotransferase), [RefSeq, PubMed]; Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (By similarity). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3F4S6;Q6IU00", "ec_number_list": "", "go_molecular_function": "GO:0015067 amidinotransferase activity;GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007611 learning or memory;GO:0006601 creatine biosynthetic process;GO:0014889 muscle atrophy;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50441-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50555-1", "uniprot_id": "TNR1A_PIG", "mass": 50696.0, "length": 461, "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "TNFRSF1A", "organism": "Pig", "refseq_name": "tumor necrosis factor receptor superfamily member 1A precursor", "refseq_ac": "NP_999134", "gene_names_uniprotkb": "TNFRSF1A; TNFR1", "gene_names_refseq": "TNFRSF1A", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor type I; p55; p60", "protein_names_refseq": "TNF-R1; TNF-RI; TNFR-I; p55 TNF receptor; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily member 1A precursor; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor type I", "tax_id": 9823, "disease": "", "pathway": " (ssc:397020)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21152396;30914326;7590278", "class_list": "", "function": "Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity)., [UniProtKB]; Results indicated that TNFRSF1A activated the TNF signaling pathway and inhibited the NFkappaB signaling pathway in vitro. These findings provide evidence for an immune-related regulatory function for porcine TNFRSF1A., [RefSeq, PubMed]; Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043120 tumor necrosis factor binding;GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52649-1", "uniprot_id": "CY24B_PIG", "mass": 65457.0, "length": 570, "protein_name": "NADPH oxidase 2", "gene_name": "CYBB", "organism": "Pig", "refseq_name": "NADPH oxidase 2", "refseq_ac": "NP_999208", "gene_names_uniprotkb": "CYBB", "gene_names_refseq": "CYBB; GP91-PHOX; NOX2", "protein_names_uniprotkb": "NADPH oxidase 2; 1.6.3.-; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome", "protein_names_refseq": "CGD91-phox; Cytochrome b-245 heavy chain; NADPH oxidase 2; NADPH oxidase heavy chain subunit; cytochrome b(558) subunit beta; cytochrome b558 subunit beta; gp91-1; heme-binding membrane glycoprotein gp91phox; neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome", "tax_id": 9823, "disease": "", "pathway": " (ssc:397108)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18757525;19562688;25017967;26211713;29183727;31662816;7857983", "class_list": "", "function": "Activated during ischemia/reperfusion in a complement-dependent manner, and may contribute to the renal damage, [RefSeq, PubMed]; Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Reactive oxygen species generated by NADPH oxidase contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia., [RefSeq, PubMed]; Sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 kinase-mediated production of superoxide from NADPH oxidase following ETA receptor activation, [RefSeq, PubMed]; The effect and molecular mechanisms of SGK1 in renal tubular cells upon oxidative stress injury. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggested that resveratrol strongly enhances the RA-induced O2(-)-generating activity via up-regulation of gp91-phox gene expression in U937 cells., [RefSeq, PubMed]; Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "K7GKS3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0070402 NADPH binding;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006952 defense response;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0034220 monoatomic ion transmembrane transport;GO:0006801 superoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53590-1", "uniprot_id": "SUCB2_PIG", "mass": 46803.0, "length": 433, "protein_name": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "gene_name": "SUCLG2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SUCLG2", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; 6.2.1.-; 6.2.1.4; G-SCS; GTP-specific succinyl-CoA synthetase subunit beta; GTPSCS; Itaconyl--CoA ligase [GDP-forming] subunit beta; Malyl--CoA ligase [GDP-forming] subunit beta; SCS-betaG; Succinyl-CoA synthetase beta-G chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10873456;16481318;26249701;27487822;8401211;8672129", "class_list": "", "function": "GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:8401211, PubMed:27487822). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase (By similarity)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95279", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004776 succinate-CoA ligase (GDP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042709 succinate-CoA ligase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53714-1", "uniprot_id": "ITB2_PIG", "mass": 84790.0, "length": 769, "protein_name": "Integrin beta-2", "gene_name": "ITGB2", "organism": "Pig", "refseq_name": "integrin beta-2 precursor", "refseq_ac": "NP_999073", "gene_names_uniprotkb": "ITGB2; CD18", "gene_names_refseq": "CD18; ITGB2", "protein_names_uniprotkb": "Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta", "protein_names_refseq": "CD18 leukocyte adhesion molecule; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2 precursor; integrin beta-2", "tax_id": 9823, "disease": "", "pathway": " (ssc:396943)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18782273;19356397;21295838;25453580", "class_list": "", "function": "CR3 plays a cardinal role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans., [RefSeq, PubMed]; Early CD18 downregulation is profitable for the host in a situation with an intense LPS stimulus, [RefSeq, PubMed]; Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL:ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis. Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells., [UniProtKB, UniProtKB]; It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis., [RefSeq, PubMed]; The expression of zona pellucida glycoprotein 3 and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft;GO:0008305 integrin complex", "go_biological_process": "GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0007229 integrin-mediated signaling pathway;GO:0031623 receptor internalization;GO:0006909 phagocytosis;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55931-1", "uniprot_id": "ETFD_PIG", "mass": 68635.0, "length": 617, "protein_name": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "gene_name": "ETFDH", "organism": "Pig", "refseq_name": "electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial isoform 1", "refseq_ac": "XP_003129051", "gene_names_uniprotkb": "ETFDH", "gene_names_refseq": "ETF-QO; ETFDH", "protein_names_uniprotkb": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; 1.5.5.1; ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; Electron-transferring-flavoprotein dehydrogenase", "protein_names_refseq": "ETF dehydrogenase; ETF-ubiquinone oxidoreductase; Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial isoform 1; electron-transferring-flavoprotein dehydrogenase", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515785)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17050691;17407547;32543654;8306995", "class_list": "", "function": "Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8W4FK45", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56432-1", "uniprot_id": "JUN_PIG", "mass": 35629.0, "length": 331, "protein_name": "Transcription factor Jun", "gene_name": "JUN", "organism": "Pig", "refseq_name": "transcription factor Jun", "refseq_ac": "NP_999045", "gene_names_uniprotkb": "JUN", "gene_names_refseq": "C-JUN; JUN", "protein_names_uniprotkb": "Transcription factor Jun; AP1; Activator protein 1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog", "protein_names_refseq": "AP1; V-jun avian sarcoma virus 17 oncogene homolog; activator protein 1; proto-oncogene c-jun; transcription factor AP-1 subunit Jun; transcription factor AP-1; transcription factor Jun", "tax_id": 9823, "disease": "", "pathway": " (ssc:396913)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23089279;28347884;28931675;32772776;33930700;8793856", "class_list": "", "function": "MiR-128 regulated the proliferation and autophagy in porcine adipose-derived stem cells through targeting the JNK signaling pathway., [RefSeq, PubMed]; Porcine reproductive and respiratory syndrome virus -activated TAK-1 was essential for the activation of JNK and NF-kappaB pathways and IL-8 expression., [RefSeq, PubMed]; Porcine reproductive and respiratory syndrome virus increases SOCS3 production via activation of p38/AP-1 signaling pathway to promote viral replication., [RefSeq, PubMed]; Study highlights the role of AP1 in promoting the host gene expression profile that defines Ebola virus pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The effects of prostaglandin F2alpha administration on transcription factor AP-1 expression and the expression of downstream genes involved in luteolysis are reported., [RefSeq, PubMed]; Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity). Interacts with FOSB to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 site of FASLG/CD95L, and activating its transcription in T cells upon stimulation by TCR/CD3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56941-1", "uniprot_id": "NPC1_PIG", "mass": 141963.0, "length": 1277, "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "NPC1", "organism": "Pig", "refseq_name": "NPC intracellular cholesterol transporter 1 precursor", "refseq_ac": "NP_999487", "gene_names_uniprotkb": "NPC1", "gene_names_refseq": "NPC1", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein", "protein_names_refseq": "NPC intracellular cholesterol transporter 1 precursor; Niemann-Pick C disease protein; Niemann-Pick type C1 protein; niemann-Pick C1 protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397591)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11796528", "class_list": "", "function": "Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Mediates cholesterol transfer from lysosomes to endoplasmic reticulum by tethering endosomal/lysosomal compartments and endoplasmic reticulum membrane contact sites where it interacts with sterol transport protein GRAMD1B. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9., [UniProtKB, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 16, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0030299 intestinal cholesterol absorption;GO:0032367 intracellular cholesterol transport;GO:0042632 cholesterol homeostasis;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61013-1", "uniprot_id": "PPLA_PIG", "mass": 6080.0, "length": 52, "protein_name": "Phospholamban", "gene_name": "PLN", "organism": "Pig", "refseq_name": "phospholamban", "refseq_ac": "NP_999378", "gene_names_uniprotkb": "PLN", "gene_names_refseq": "PLN", "protein_names_uniprotkb": "Phospholamban; PLB", "protein_names_refseq": "PLB; cardiac phospholamban; phospholamban", "tax_id": 9823, "disease": "", "pathway": " (ssc:397421); (R-SSC-5578775); (R-SSC-936837)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15697203;15801907;19191503;2530978", "class_list": "", "function": "Molecular dynamics simulations of phospholamban in solution and in membrane bilayer show two main features: the presence of two well-defined helical domains at the N- and C-termini, and large-amplitude rigid-body motions of these domains., [RefSeq, PubMed]; Phosphorylation of PLB induces spatial rearrangements between the N- and P-domain elements of proximal Ca-ATPase., [RefSeq, PubMed]; Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning., [UniProtKB, UniProtKB, UniProtKB]; The expression of SLN and PLB mRNA and protein relative to SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07473", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0042030 ATPase inhibitor activity;GO:0141110 transporter inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0008542 visual learning;GO:0006874 intracellular calcium ion homeostasis;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62802-1", "uniprot_id": "H4_PIG", "mass": 11367.0, "length": 103, "protein_name": "Histone H4", "gene_name": "", "organism": "Pig", "refseq_name": "histone H4", "refseq_ac": "XP_020945589", "gene_names_uniprotkb": "", "gene_names_refseq": "LOC100621389", "protein_names_uniprotkb": "Histone H4", "protein_names_refseq": "histone H4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100158117); (ssc:100621389); (ssc:110261477); (ssc:110261487); (ssc:110261673); (ssc:110261674); (ssc:110261675); (R-SSC-110330); (R-SSC-110331); (R-SSC-171306); (R-SSC-201722); (R-SSC-212300); (R-SSC-2299718); (R-SSC-2559580); (R-SSC-2559582); (R-SSC-2559586); (R-SSC-3214841); (R-SSC-3214842); (R-SSC-3214847); (R-SSC-3214858); (R-SSC-427359); (R-SSC-4551638); (R-SSC-5250924); (R-SSC-5578749); (R-SSC-5625886); (R-SSC-5693565); (R-SSC-5693571); (R-SSC-5693607); (R-SSC-606279); (R-SSC-68616); (R-SSC-69473); (R-SSC-73728); (R-SSC-73772); (R-SSC-8936459); (R-SSC-9018519); (R-SSC-9670095); (R-SSC-9764725); (R-SSC-9841922); (R-SSC-9843940); (R-SSC-9843970); (R-SSC-9909649); (R-SSC-9940951); (R-SSC-9943411); (R-SSC-9943962); (R-SSC-9970672)", "pathway_count": 45, "publication_count": 1, "publication_id_list": "5123897", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02304;P02305", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63053-1", "uniprot_id": "RL40_PIG", "mass": 14728.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "organism": "Pig", "refseq_name": "ubiquitin-ribosomal protein eL40 fusion protein", "refseq_ac": "NP_999376", "gene_names_uniprotkb": "UBA52; UBCEP2", "gene_names_refseq": "UBA52; UBCEP2", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "CEP52; ubiquitin-60S ribosomal protein L40; ubiquitin-ribosomal protein eL40 fusion protein; ubiquitin/ribosomal fusion protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397418); (R-SSC-110312); (R-SSC-110314); (R-SSC-110320); (R-SSC-1169091); (R-SSC-1234176); (R-SSC-1253288); (R-SSC-1295596); (R-SSC-1358803); (R-SSC-156827); (R-SSC-174048); (R-SSC-174084); (R-SSC-174154); (R-SSC-174178); (R-SSC-174184); (R-SSC-179409); (R-SSC-1799339); (R-SSC-182971); (R-SSC-187577); (R-SSC-195253); (R-SSC-202424); (R-SSC-209543); (R-SSC-209560); (R-SSC-2122948); (R-SSC-2173788); (R-SSC-2173791); (R-SSC-2173795); (R-SSC-2173796); (R-SSC-2467813); (R-SSC-2559582); (R-SSC-2672351); (R-SSC-2871837); (R-SSC-3134975); (R-SSC-349425); (R-SSC-3769402); (R-SSC-382556); (R-SSC-445989); (R-SSC-450302); (R-SSC-450321); (R-SSC-450408); (R-SSC-4608870); (R-SSC-4641257); (R-SSC-4641258); (R-SSC-4641263); (R-SSC-532668); (R-SSC-5357905); (R-SSC-5357956); (R-SSC-5358346); (R-SSC-5607761); (R-SSC-5607764); (R-SSC-5632684); (R-SSC-5654726); (R-SSC-5654727); (R-SSC-5654732); (R-SSC-5654733); (R-SSC-5655862); (R-SSC-5656121); (R-SSC-5656169); (R-SSC-5668541); (R-SSC-5675221); (R-SSC-5675482); (R-SSC-5676590); (R-SSC-5684264); (R-SSC-5685942); (R-SSC-5687128); (R-SSC-5689603); (R-SSC-5689877); (R-SSC-5689880); (R-SSC-5689896); (R-SSC-5689901); (R-SSC-5693537); (R-SSC-5693565); (R-SSC-5696394); (R-SSC-5696395); (R-SSC-5696397); (R-SSC-5696400); (R-SSC-6781823); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-6783310); (R-SSC-6791226); (R-SSC-6804756); (R-SSC-6804757); (R-SSC-6804760); (R-SSC-6807004); (R-SSC-68867); (R-SSC-68949); (R-SSC-69017); (R-SSC-69231); (R-SSC-69481); (R-SSC-69601); (R-SSC-72689); (R-SSC-72706); (R-SSC-75815); (R-SSC-8849469); (R-SSC-8852276); (R-SSC-8854050); (R-SSC-8856825); (R-SSC-8856828); (R-SSC-8863795); (R-SSC-8866427); (R-SSC-8866652); (R-SSC-8866654); (R-SSC-8939236); (R-SSC-8939902); (R-SSC-8941858); (R-SSC-8948747); (R-SSC-8948751); (R-SSC-8951664); (R-SSC-901032); (R-SSC-9020702); (R-SSC-9033241); (R-SSC-909733); (R-SSC-912631); (R-SSC-917729); (R-SSC-917937); (R-SSC-936440); (R-SSC-936964); (R-SSC-937039); (R-SSC-937041); (R-SSC-937042); (R-SSC-937072); (R-SSC-9645460); (R-SSC-9646399); (R-SSC-9648002); (R-SSC-9664873); (R-SSC-9706369); (R-SSC-9708530); (R-SSC-975144); (R-SSC-975163); (R-SSC-9755511); (R-SSC-9758274); (R-SSC-975956); (R-SSC-975957); (R-SSC-9766229); (R-SSC-9770562); (R-SSC-9824878); (R-SSC-983168); (R-SSC-9861718); (R-SSC-9929491); (R-SSC-9931269); (R-SSC-9931295); (R-SSC-9932298); (R-SSC-9954709); (R-SSC-9954714); (R-SSC-9954716); (R-SSC-9958810); (R-SSC-9958825)", "pathway_count": 148, "publication_count": 3, "publication_id_list": "12042320;15565337;9089280", "class_list": "", "function": "Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P62974;Q29120;Q29203;Q29252;Q91887;Q91888;Q95260", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67776-1", "uniprot_id": "PP2AA_PIG", "mass": 35594.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "organism": "Pig", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "refseq_ac": "NP_999531", "gene_names_uniprotkb": "PPP2CA", "gene_names_refseq": "PPP2CA", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; 3.1.3.16; PP2A-alpha", "protein_names_refseq": "PP2A-alpha; protein phosphatase 2,catalytic subunit alpha isozyme; protein phosphatase 2A alpha subunit; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "tax_id": 9823, "disease": "", "pathway": " (ssc:397656); (R-SSC-113501); (R-SSC-1295596); (R-SSC-141430); (R-SSC-141444); (R-SSC-180024); (R-SSC-195253); (R-SSC-196299); (R-SSC-198753); (R-SSC-202670); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-2995383); (R-SSC-389356); (R-SSC-389513); (R-SSC-432142); (R-SSC-4641262); (R-SSC-5663220); (R-SSC-5673000); (R-SSC-5675221); (R-SSC-6811558); (R-SSC-68877); (R-SSC-69231); (R-SSC-69273); (R-SSC-9648025); (R-SSC-975957); (R-SSC-9833482); (R-SSC-9860927)", "pathway_count": 28, "publication_count": 4, "publication_id_list": "18292600;19109948;2827745;31618847", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promoting PIM3 ubiquitination and proteasomal degradation. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex. The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hsp27 is dephosphorylated by PP2A in dorsal ruffles, in non-caveolar lipid raft microdomains., [RefSeq, PubMed]; PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production. Publication Status: Online-Only, [RefSeq, PubMed]; PP2A and AIP1 cooperatively induce activation of ASK1-JNK signaling and vascular endothelial cell apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05323;P13197", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0019888 protein phosphatase regulator activity;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P67776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79263-1", "uniprot_id": "ITIH4_PIG", "mass": 102146.0, "length": 921, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H4", "gene_name": "ITIH4", "organism": "Pig", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor", "refseq_ac": "NP_001001537", "gene_names_uniprotkb": "ITIH4; IHRP", "gene_names_refseq": "IHRP; ITIH4", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H4; IHRP; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; MAP; Major acute phase protein", "protein_names_refseq": "ITI heavy chain H4; ITI-HC4; MAP; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heavy chain-related protein; inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor heavy chain family member 4; major acute phase protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:396799)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10712621;16275952;1697703;7556597;8830057", "class_list": "", "function": "Promoter of ITIH4 major acute phase protein has been isolated, cloned, and proven functional by response to an inflammatory stimulus (interleukin-6) in human Hep3B cells. (inter-alpha-trypsin heavy chain 4; ITIH4), [RefSeq, PubMed]; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0034097 response to cytokine;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79274-1", "uniprot_id": "ACADL_PIG", "mass": 47957.0, "length": 430, "protein_name": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADL", "organism": "Pig", "refseq_name": "long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": "NP_999062", "gene_names_uniprotkb": "ACADL", "gene_names_refseq": "ACADL", "protein_names_uniprotkb": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; 1.3.8.8; LCAD; Medium-chain acyl-CoA dehydrogenase, mitochondrial", "protein_names_refseq": "LCAD; acyl-Coenzyme A dehydrogenase, long chain; long-chain acyl-CoA dehydrogenase; long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; long-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain acyl-CoA dehydrogenase, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:396931); (R-SSC-77285); (R-SSC-77310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase activity overlaps with that of ACADV and ACAD9, acting on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. Can use (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate as substrate in vitro (which is not primarily used for energy but mainly beta-oxidized in the peroxisomes). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Plays a primary role in FAO in tissues where it is the main long-chain ACAD expressed. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0042758 long-chain fatty acid catabolic process;GO:0019254 carnitine metabolic process, CoA-linked", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79274-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79281-1", "uniprot_id": "PTN_PIG", "mass": 18910.0, "length": 168, "protein_name": "Pleiotrophin", "gene_name": "PTN", "organism": "Pig", "refseq_name": "pleiotrophin precursor", "refseq_ac": "NP_999501", "gene_names_uniprotkb": "PTN", "gene_names_refseq": "PTF-BETA; PTN", "protein_names_uniprotkb": "Pleiotrophin; PTF-beta; PTN; Pleiotrophic factor beta", "protein_names_refseq": "pleiotrophic factor beta; pleiotrophin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397609); (R-SSC-201556); (R-SSC-9851151)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15632143", "class_list": "", "function": "A heparin-binding growth factor, produced mainly by glia cells, was the predominant binding partner for chondroitin and dermatan sulfate hybrid chain biosynthesis., [RefSeq, PubMed]; Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0048680 positive regulation of axon regeneration;GO:0007229 integrin-mediated signaling pathway;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79282-1", "uniprot_id": "FUT8_PIG", "mass": 66229.0, "length": 575, "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "FUT8", "organism": "Pig", "refseq_name": "alpha-(1,6)-fucosyltransferase", "refseq_ac": "NP_999064", "gene_names_uniprotkb": "FUT8", "gene_names_refseq": "FUT8", "protein_names_uniprotkb": "Alpha-(1,6)-fucosyltransferase; 2.4.1.68; Alpha1-6FucT; Fucosyltransferase 8; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase", "protein_names_refseq": "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; N-acetyl-beta-D-glucosaminidealpha-1, 6-fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha1-6FucT; glycoprotein 6-alpha-L-fucosyltransferase", "tax_id": 9823, "disease": "", "pathway": " (ssc:396933)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8910378", "class_list": "", "function": "Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046921 alpha-(1->6)-fucosyltransferase activity;GO:0017124 SH3 domain binding;GO:0016757 glycosyltransferase activity;GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0046368 GDP-L-fucose metabolic process", "synthesized_glycan_count": 6717, "hit_score": 0.2, "record_id": "P79282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79307-1", "uniprot_id": "A4_PIG", "mass": 86961.0, "length": 770, "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "organism": "Pig", "refseq_name": "amyloid-beta precursor protein precursor", "refseq_ac": "NP_999537", "gene_names_uniprotkb": "APP; A4; AD1", "gene_names_refseq": "A4; AD1; APP", "protein_names_uniprotkb": "Amyloid-beta precursor protein; ABPP; APP; Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59)", "protein_names_refseq": "ABPP; alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid precursor protein; amyloid-beta (A4) precursor protein; amyloid-beta precursor protein precursor; beta-amyloid precursor protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397663); (R-SSC-114608); (R-SSC-3000178); (R-SSC-381426); (R-SSC-432720); (R-SSC-445989); (R-SSC-879415); (R-SSC-8957275); (R-SSC-933542); (R-SSC-9609523); (R-SSC-9769739); (R-SSC-9837999)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "15202933;1656157;16934345;17335780;21203512;22661126;33500491", "class_list": "", "function": "APP could be acting through a semaphorin receptor as well, [RefSeq, PubMed]; APPsw mutation for Alzheimer's disease is not associated with object recognition., [RefSeq, PubMed]; Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47-dependent manner Publication Status: Online-Only, [RefSeq, PubMed]; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity)., [UniProtKB]; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity)., [UniProtKB, UniProtKB]; Reduction of pTau and APP levels in mammalian brain after low-dose radiation. Publication Status: Online-Only, [RefSeq, PubMed]; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis., [UniProtKB]; These experiments demonstrate the roles of Chol and ApoE in the modulation of membrane insertion of APP., [RefSeq, PubMed]; Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q29023;Q9TUI0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0030546 signaling receptor activator activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0006878 intracellular copper ion homeostasis;GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P79307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79383-1", "uniprot_id": "CP2E1_PIG", "mass": 57095.0, "length": 495, "protein_name": "Cytochrome P450 2E1", "gene_name": "CYP2E1", "organism": "Pig", "refseq_name": "cytochrome P450 2E1", "refseq_ac": "NP_999586", "gene_names_uniprotkb": "CYP2E1; CYP2E", "gene_names_refseq": "CYP2E1", "protein_names_uniprotkb": "Cytochrome P450 2E1; 1.14.13.n7; 1.14.14.1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P-450-J; Cytochrome P450-J", "protein_names_refseq": "4-nitrophenol 2-hydroxylase; CYPIIE1; cytochrome P-450-J; cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450-J", "tax_id": 9823, "disease": "", "pathway": " (ssc:403216)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16821288;22558788;24894739;30171805", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics., [UniProtKB, UniProtKB]; A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14. Publication Status: Online-Only, [RefSeq, PubMed]; The G --> A substitute might be at least partially responsible for a high level of skatole in pigs, [RefSeq, PubMed]; The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported., [RefSeq, PubMed]; This study summarises the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. [Review] Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P79383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79386-1", "uniprot_id": "NR0B1_PIG", "mass": 52128.0, "length": 471, "protein_name": "Nuclear receptor subfamily 0 group B member 1", "gene_name": "NR0B1", "organism": "Pig", "refseq_name": "nuclear receptor subfamily 0 group B member 1", "refseq_ac": "NP_999552", "gene_names_uniprotkb": "NR0B1; AHCH; DAX1", "gene_names_refseq": "AHC; DAX-1; NR0B1", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1", "protein_names_refseq": "adrenal hypoplasia congenital; nuclear receptor DAX-1; nuclear receptor subfamily 0 group B member 1; orphan nuclear receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397680)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9453240", "class_list": "", "function": "Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis (By similarity). May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46520", "ec_number_list": "", "go_molecular_function": "GO:0032448 DNA hairpin binding;GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005840 ribosome", "go_biological_process": "GO:0007530 sex determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79403-1", "uniprot_id": "GANAB_PIG", "mass": 106662.0, "length": 944, "protein_name": "Neutral alpha-glucosidase AB", "gene_name": "GANAB", "organism": "Pig", "refseq_name": "neutral alpha-glucosidase AB precursor", "refseq_ac": "NP_999069", "gene_names_uniprotkb": "GANAB", "gene_names_refseq": "G2AN; GANAB", "protein_names_uniprotkb": "Neutral alpha-glucosidase AB; 3.2.1.207; Alpha-glucosidase 2; Glucosidase II subunit alpha", "protein_names_refseq": "alpha-glucosidase 2; glucosidase II subunit alpha; neutral alpha-glucosidase AB precursor; neutral alpha-glucosidase AB", "tax_id": 9823, "disease": "", "pathway": " (ssc:396938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2404989", "class_list": "", "function": "Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033919 glucan 1,3-alpha-glucosidase activity;GO:0090599 alpha-glucosidase activity;GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0043231 intracellular membrane-bounded organelle;GO:0042470 melanosome;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79403-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79432-1", "uniprot_id": "CDK4_PIG", "mass": 33690.0, "length": 303, "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "organism": "Pig", "refseq_name": "cyclin-dependent kinase 4", "refseq_ac": "NP_001116569", "gene_names_uniprotkb": "CDK4", "gene_names_refseq": "CDK4", "protein_names_uniprotkb": "Cyclin-dependent kinase 4; 2.7.11.22; Cell division protein kinase 4", "protein_names_refseq": "cell division protein kinase 4; cyclin-dependent kinase 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144492); (R-SSC-187577); (R-SSC-2559580); (R-SSC-2559582); (R-SSC-2559585); (R-SSC-3214858); (R-SSC-69231); (R-SSC-75815); (R-SSC-8849470); (R-SSC-8878166); (R-SSC-9616222); (R-SSC-9754119); (R-SSC-9929491)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "23827822;35189966", "class_list": "", "function": "Expression of CDK4 is down regulated in the heart, kidney and spleen of late gestation fetuses compromised by viral infection Publication Status: Online-Only, [RefSeq, PubMed]; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)., [UniProtKB, UniProtKB]; The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80015-1", "uniprot_id": "CAP7_PIG", "mass": 27039.0, "length": 246, "protein_name": "Azurocidin", "gene_name": "AZU1", "organism": "Pig", "refseq_name": "azurocidin precursor", "refseq_ac": "XP_005661477", "gene_names_uniprotkb": "AZU1", "gene_names_refseq": "AZU1; Azurocidin; HBP; pHBP", "protein_names_uniprotkb": "Azurocidin; Cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; pHBP", "protein_names_refseq": "Cationic antimicrobial protein CAP37; Heparin-binding protein; azurocidin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522363); (R-SSC-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2026172;2076469;32543654", "class_list": "", "function": "This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0035577 azurophil granule membrane;GO:0042582 azurophil granule", "go_biological_process": "GO:0001774 microglial cell activation;GO:0006508 proteolysis;GO:0035556 intracellular signal transduction;GO:0045785 positive regulation of cell adhesion;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80015-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80310-1", "uniprot_id": "S10AC_PIG", "mass": 10745.0, "length": 92, "protein_name": "Protein S100-A12", "gene_name": "S100A12", "organism": "Pig", "refseq_name": "protein S100-A12", "refseq_ac": "NP_001153744", "gene_names_uniprotkb": "S100A12", "gene_names_refseq": "CAGC; S100A12", "protein_names_uniprotkb": "Protein S100-A12; CAGC; Calgranulin-C; EN-RAGE; Extracellular newly identified RAGE-binding protein; S100 calcium-binding protein A12", "protein_names_refseq": "EN-RAGE; calgranulin-C; extracellular newly identified RAGE-binding protein; protein S100-A12", "tax_id": 9823, "disease": "", "pathway": " (ssc:100301483); (R-SSC-445989); (R-SSC-6798695); (R-SSC-879415); (R-SSC-933542)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "20189650;7961855", "class_list": "", "function": "S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity)., [UniProtKB]; Show that pS100A12 is expressed preferentially in immune organs/tissues, e.g., bone marrow, spleen, and inguinal lymph nodes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80928-1", "uniprot_id": "MIF_PIG", "mass": 12451.0, "length": 115, "protein_name": "Macrophage migration inhibitory factor", "gene_name": "MIF", "organism": "Pig", "refseq_name": "macrophage migration inhibitory factor", "refseq_ac": "NP_001070681", "gene_names_uniprotkb": "MIF", "gene_names_refseq": "MIF", "protein_names_uniprotkb": "Macrophage migration inhibitory factor; 5.3.2.1; 5.3.3.12; GIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; MIF; Phenylpyruvate tautomerase", "protein_names_refseq": "GIF; L-dopachrome isomerase; L-dopachrome tautomerase; glycosylation-inhibiting factor; macrophage migration inhibitory factor; phenylpyruvate tautomerase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397412); (R-SSC-202733); (R-SSC-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15564603;20093039;9785043", "class_list": "", "function": "Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity., [UniProtKB, UniProtKB]; The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation, [RefSeq, PubMed]; Transcription of MIF is induced by activation of PPARgamma2 and inhibited by excessive resistin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q069I4;Q9TUM7", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0010629 negative regulation of gene expression;GO:0045087 innate immune response;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P80928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81140-1", "uniprot_id": "GCDH_PIG", "mass": 45123.0, "length": 408, "protein_name": "Glutaryl-CoA dehydrogenase, mitochondrial", "gene_name": "GCDH", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GCDH", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutaryl-CoA dehydrogenase, mitochondrial; 1.3.8.6; GCD", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1438360", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004361 glutaryl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046949 fatty-acyl-CoA biosynthetic process;GO:0006568 L-tryptophan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81140-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81608-1", "uniprot_id": "SAL_PIG", "mass": 21588.0, "length": 191, "protein_name": "Salivary lipocalin", "gene_name": "SAL1", "organism": "Pig", "refseq_name": "salivary lipocalin precursor", "refseq_ac": "NP_998979", "gene_names_uniprotkb": "SAL1", "gene_names_refseq": "SAL1", "protein_names_uniprotkb": "Salivary lipocalin; SAL", "protein_names_refseq": "SAL; salivary lipocalin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396739)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10947950;12027882;14578123;20881314;9546674", "class_list": "", "function": "Binds pheromones, the pheromones are released from the saliva of males and affect the sexual behavior of females., [UniProtKB]; Involvement in the detection of appeasing compounds in the nasal mucosa and the vomeronasal organ of pre-pubertal pigs, [RefSeq, PubMed]; SAL1 present at maternal-fetal interface may act as histotroph and play important role in establishment of pregnancy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9N0K0", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P81608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98074-1", "uniprot_id": "ENTK_PIG", "mass": 114776.0, "length": 1034, "protein_name": "Enteropeptidase", "gene_name": "TMPRSS15", "organism": "Pig", "refseq_name": "enteropeptidase proprotein", "refseq_ac": "NP_001001259", "gene_names_uniprotkb": "TMPRSS15; ENTK; PRSS7", "gene_names_refseq": "PRSS7; TMPRSS15", "protein_names_uniprotkb": "Enteropeptidase; 3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15", "protein_names_refseq": "enterokinase; enteropeptidase proprotein; enteropeptidase, light chain (L chain); protease, serine, 7 (enterokinase); serine protease 7; transmembrane protease, serine 15", "tax_id": 9823, "disease": "", "pathway": " (ssc:397152)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18323639;8051081", "class_list": "", "function": "Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases., [UniProtKB]; Substrate specificities of porcine and bovine enteropeptidases were investigated using the peptide Val-(Asp)(4)-Lys-Ile-Val-Gly and its various analogs with mutations in the (Asp)(4)-Lys sequence as substrates, [RefSeq, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 22, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q007T2-1", "uniprot_id": "CDC42_PIG", "mass": 21259.0, "length": 191, "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "organism": "Pig", "refseq_name": "cell division control protein 42 homolog", "refseq_ac": "NP_001072148", "gene_names_uniprotkb": "CDC42", "gene_names_refseq": "CDC42", "protein_names_uniprotkb": "Cell division control protein 42 homolog; 3.6.5.2", "protein_names_refseq": "cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa)", "tax_id": 9823, "disease": "", "pathway": " (ssc:780428); (R-SSC-114604); (R-SSC-182971); (R-SSC-2029482); (R-SSC-389359); (R-SSC-3928662); (R-SSC-4420097); (R-SSC-525793); (R-SSC-5625970); (R-SSC-5626467); (R-SSC-5627123); (R-SSC-5663213); (R-SSC-5663220); (R-SSC-5687128); (R-SSC-8964616); (R-SSC-9013148); (R-SSC-9013149); (R-SSC-9013404); (R-SSC-9013406); (R-SSC-9013408); (R-SSC-9013420); (R-SSC-9013423); (R-SSC-9013424); (R-SSC-983231); (R-SSC-9958810); (R-SSC-9958825)", "pathway_count": 26, "publication_count": 4, "publication_id_list": "14681463;20016221;25281640;28781348", "class_list": "", "function": "CDC42 is an indispensable protein during porcine oocyte meiosis, and CDC42 may interact with N-WASP, ROCK, and cofilin in the assembly of actin filaments during porcine oocyte maturation., [RefSeq, PubMed]; Cdc42 is involved in the regulation of alppha-smooth muscle actin promoter activation through p21-activated kinase, p38, myocardin-related transcription factor and serum response factor. Cdc42 may be an important regulator of MRTF cellular localization, [RefSeq, PubMed]; Hypoxic pulmonary arterial myocytes challenged with a thromboxane mimetic polymerize actin via the Cdc42 pathway, reflecting increased Cdc42 association with neuronal Wiskott Aldrich Syndrome protein., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (By similarity). Negatively regulates polymerization of SEPTIN12, as a result may be involved in spermatogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D1YSL6", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q007T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q007T5-1", "uniprot_id": "ARF6_PIG", "mass": 20082.0, "length": 175, "protein_name": "ADP-ribosylation factor 6", "gene_name": "ARF6", "organism": "Pig", "refseq_name": "ADP-ribosylation factor 6", "refseq_ac": "NP_001072145", "gene_names_uniprotkb": "ARF6", "gene_names_refseq": "ARF6", "protein_names_uniprotkb": "ADP-ribosylation factor 6; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 6", "tax_id": 9823, "disease": "", "pathway": " (ssc:780425); (R-SSC-8854214); (R-SSC-8875656)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0031996 thioesterase binding;GO:0035591 signaling adaptor activity;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903438 positive regulation of mitotic cytokinetic process;GO:0006886 intracellular protein transport;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q007T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01580-1", "uniprot_id": "HBEGF_PIG", "mass": 22986.0, "length": 208, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "HBEGF", "organism": "Pig", "refseq_name": "proheparin-binding EGF-like growth factor precursor", "refseq_ac": "NP_999464", "gene_names_uniprotkb": "HBEGF; DTR; HEGFL", "gene_names_refseq": "DTR; HBEGF", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "diphtheria toxin receptor; heparin-binding epidermal growth factor-like growth factor; proheparin-binding EGF-like growth factor precursor; proheparin-binding EGF-like growth factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397564); (R-SSC-1227986); (R-SSC-1236394); (R-SSC-1250196); (R-SSC-1250342); (R-SSC-1250347); (R-SSC-1257604); (R-SSC-177929); (R-SSC-179812); (R-SSC-180292); (R-SSC-180336); (R-SSC-182971); (R-SSC-1963640); (R-SSC-1963642); (R-SSC-212718); (R-SSC-2179392); (R-SSC-5673001); (R-SSC-6785631); (R-SSC-6811558); (R-SSC-8847993); (R-SSC-8856825); (R-SSC-8856828); (R-SSC-8857538); (R-SSC-8863795); (R-SSC-9009391)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "1445231", "class_list": "", "function": "Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051549 positive regulation of keratinocyte migration;GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q01580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02038-1", "uniprot_id": "NEUL_PIG", "mass": 80757.0, "length": 704, "protein_name": "Neurolysin, mitochondrial", "gene_name": "NLN", "organism": "Pig", "refseq_name": "neurolysin, mitochondrial", "refseq_ac": "NP_999524", "gene_names_uniprotkb": "NLN", "gene_names_refseq": "NLN", "protein_names_uniprotkb": "Neurolysin, mitochondrial; 3.4.24.16; Endopeptidase 24.16; MEP; Microsomal endopeptidase; Mitochondrial oligopeptidase M; Neurotensin endopeptidase; SABP; Soluble angiotensin-binding protein", "protein_names_refseq": "MEP; SABP; endopeptidase 24.16; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin, mitochondrial; neurotensin endopeptidase; soluble angiotensin-binding protein; soluble angiotesin-binding protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397646); (R-SSC-375276)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1517239;9182559", "class_list": "", "function": "Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P79433;Q7JK54", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02038-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02110-1", "uniprot_id": "HPPD_PIG", "mass": 45064.0, "length": 393, "protein_name": "4-hydroxyphenylpyruvate dioxygenase", "gene_name": "HPD", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HPD", "gene_names_refseq": "", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase; 1.13.11.27; 2.1.1.348; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; N(6)-adenosine-methyltransferase HPD", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1339442", "class_list": "", "function": "Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q02110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04745-1", "uniprot_id": "IL4_PIG", "mass": 15023.0, "length": 133, "protein_name": "Interleukin-4", "gene_name": "IL4", "organism": "Pig", "refseq_name": "interleukin-4 precursor", "refseq_ac": "NP_999288", "gene_names_uniprotkb": "IL4", "gene_names_refseq": "IL4", "protein_names_uniprotkb": "Interleukin-4; B-cell stimulatory factor 1; BSF-1; IL-4; Lymphocyte stimulatory factor 1", "protein_names_refseq": "B-cell stimulatory factor 1; BSF-1; IL-4; interleukin-4 precursor; lymphocyte stimulatory factor 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397225); (R-SSC-6785807)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17082655;18761033;19766617;20017192;21572032;8424960", "class_list": "", "function": "IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection., [RefSeq, PubMed]; IL-4- and IL-10-producing invariant NKT cells inhibit the Th1 cell response, but not the Th17 cell response, [RefSeq, PubMed]; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4., [UniProtKB, UniProtKB]; The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood., [RefSeq, PubMed]; There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells., [RefSeq, PubMed]; Unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 secretion and suppresses antigen-stimulated proliferation of B cells Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29054;Q8MKE6", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005136 interleukin-4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0010633 negative regulation of epithelial cell migration;GO:0032736 positive regulation of interleukin-13 production;GO:0035771 interleukin-4-mediated signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04745-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06AU2-1", "uniprot_id": "RAP2A_PIG", "mass": 20504.0, "length": 183, "protein_name": "Ras-related protein Rap-2a", "gene_name": "RAP2A", "organism": "Pig", "refseq_name": "ras-related protein Rap-2a", "refseq_ac": "NP_001116657", "gene_names_uniprotkb": "RAP2A", "gene_names_refseq": "RAP2A; RAP2B", "protein_names_uniprotkb": "Ras-related protein Rap-2a; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2a", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144507); (R-SSC-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0045121 membrane raft", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030335 positive regulation of cell migration;GO:0048814 regulation of dendrite morphogenesis;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q06AU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06AU3-1", "uniprot_id": "RAB3A_PIG", "mass": 24970.0, "length": 220, "protein_name": "Ras-related protein Rab-3A", "gene_name": "RAB3A", "organism": "Pig", "refseq_name": "ras-related protein Rab-3A", "refseq_ac": "NP_001116651", "gene_names_uniprotkb": "RAB3A", "gene_names_refseq": "RAB3A", "protein_names_uniprotkb": "Ras-related protein Rab-3A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3A", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144498); (R-SSC-181429); (R-SSC-181430); (R-SSC-210500); (R-SSC-212676); (R-SSC-264642); (R-SSC-6798695); (R-SSC-8876198); (R-SSC-888590)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005764 lysosome", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0050975 sensory perception of touch;GO:0003016 respiratory system process;GO:0007274 neuromuscular synaptic transmission;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q06AU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07287-1", "uniprot_id": "ZP4_PIG", "mass": 59334.0, "length": 536, "protein_name": "Zona pellucida sperm-binding protein 4", "gene_name": "ZP4", "organism": "Pig", "refseq_name": "zona pellucida sperm-binding protein 4 precursor", "refseq_ac": "NP_999210", "gene_names_uniprotkb": "ZP4; ZP3A; ZPB", "gene_names_refseq": "ZP3-ALPHA; ZP4; ZPB; Zp-4", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 4; Zona pellucida glycoprotein 3-alpha; Zona pellucida glycoprotein 4; Zona pellucida protein B; Zp-3-alpha; Zp-4; Zp3-alpha", "protein_names_refseq": "zona pellucida glycoprotein 3-alpha; zona pellucida glycoprotein ZP3-alpha; zona pellucida protein 3-alpha; zona pellucida protein B; zona pellucida sperm-binding protein 4 precursor; zona pellucida sperm-binding protein 4; zp-3-alpha; zp3-alpha sperm-binding glycoprotein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397111); (R-SSC-2534343)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11114588;12878193;1418987;1551388;17566275;22008510;3643212;8357839;9546665", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor., [UniProtKB]; Porcine zona pellucida glycoprotein ZP4 is responsible for the sperm-binding activity of the ZP3/ZP4 complex, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0007339 binding of sperm to zona pellucida;GO:0042102 positive regulation of T cell proliferation;GO:0060468 prevention of polyspermy;GO:2000360 negative regulation of binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q07287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08353-1", "uniprot_id": "IKBA_PIG", "mass": 35230.0, "length": 314, "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "organism": "Pig", "refseq_name": "NF-kappa-B inhibitor alpha", "refseq_ac": "NP_001005150", "gene_names_uniprotkb": "NFKBIA; IKBA", "gene_names_refseq": "ECI-6/IKBA; IKBA; NFKBIA", "protein_names_uniprotkb": "NF-kappa-B inhibitor alpha; ECI-6; I-kappa-B-alpha; IkB-alpha; IkappaBalpha", "protein_names_refseq": "ECI-6; I-kappa-B-alpha; NF-kappa-B inhibitor alpha; ikB-alpha; ikappaBalpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha", "tax_id": 9823, "disease": "", "pathway": " (ssc:406188); (R-SSC-1169091); (R-SSC-1810476); (R-SSC-202424); (R-SSC-209560); (R-SSC-2871837); (R-SSC-445989); (R-SSC-4755510); (R-SSC-5607764); (R-SSC-5689880); (R-SSC-9020702); (R-SSC-933542); (R-SSC-9860927)", "pathway_count": 13, "publication_count": 5, "publication_id_list": "21450812;29115518;38501350;7835710;8334993", "class_list": "", "function": "An oligonucleotidebased method was applied to construct the vector for conditional targeting of porcine IkappaBalpha. This method was free from PCR amplification during the assembling of the different vector elements, avoiding introduction of unwanted mutations., [RefSeq, PubMed]; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription., [UniProtKB, UniProtKB]; The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKbeta and increasing the stability of IkappaBalpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Q9A9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051059 NF-kappaB binding;GO:0008139 nuclear localization sequence binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0033256 I-kappaB/NF-kappaB complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0070498 interleukin-1-mediated signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0042127 regulation of cell population proliferation;GO:0010745 negative regulation of macrophage derived foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q09136-1", "uniprot_id": "AAPK1_PIG", "mass": 44226.0, "length": 385, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRKAA1; AMPK1", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-1; 2.7.11.1; 2.7.11.26; 2.7.11.31; ACACA kinase; AMPK 63 kDa subunit; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7905477;8557660", "class_list": "", "function": "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:7905477). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45/WIPI4. Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity). Phosphorylates ALDH7A1 in response to cellular stress, such as hypoxia or ferroptotic stress, promoting ALDH7A1 recruitment to membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2MV24", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004679 AMP-activated protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0006351 DNA-templated transcription;GO:0008610 lipid biosynthetic process;GO:0010332 response to gamma radiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q09136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0MS45-1", "uniprot_id": "PSN2_PIG", "mass": 50138.0, "length": 448, "protein_name": "Presenilin-2", "gene_name": "PSEN2", "organism": "Pig", "refseq_name": "presenilin-2", "refseq_ac": "NP_001072134", "gene_names_uniprotkb": "PSEN2", "gene_names_refseq": "PS-2; PSEN2", "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; PS-2", "protein_names_refseq": "presenilin 2 (Alzheimer disease 4); presenilin-2", "tax_id": 9823, "disease": "", "pathway": " (ssc:780410); (R-SSC-1251985); (R-SSC-193692); (R-SSC-3928665); (R-SSC-9839383)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "17854491", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0MS45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0Z8U2-1", "uniprot_id": "RS3_PIG", "mass": 26688.0, "length": 243, "protein_name": "Small ribosomal subunit protein uS3", "gene_name": "RPS3", "organism": "Pig", "refseq_name": "small ribosomal subunit protein uS3", "refseq_ac": "NP_001038066", "gene_names_uniprotkb": "RPS3", "gene_names_refseq": "RPS3", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3; 4.2.99.18; 40S ribosomal protein S3", "protein_names_refseq": "40S ribosomal protein S3; small ribosomal subunit protein uS3", "tax_id": 9823, "disease": "", "pathway": " (ssc:733671); (R-SSC-156827); (R-SSC-1799339); (R-SSC-72649); (R-SSC-72689); (R-SSC-72695); (R-SSC-72702); (R-SSC-72706); (R-SSC-975956); (R-SSC-975957); (R-SSC-9954714); (R-SSC-9954716)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005743 mitochondrial inner membrane;GO:0005819 spindle;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0051301 cell division;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0Z8U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10982-1", "uniprot_id": "FUT2_PIG", "mass": 38987.0, "length": 340, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2", "gene_name": "FUT2", "organism": "Pig", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 2", "refseq_ac": "NP_999234", "gene_names_uniprotkb": "FUT2", "gene_names_refseq": "FUT2", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 2; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; alpha(1,2)FT 2; alpha-1,2-fucosyltransferase; galactoside 2-alpha-L-fucosyltransferase 2; galactoside alpha-(1,2)-fucosyltransferase 2; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "tax_id": 9823, "disease": "", "pathway": " (ssc:397139); (R-SSC-9033807); (R-SSC-9037629); (R-SSC-9840309)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11132149;26985939;29892924;7592879;9321466", "class_list": "", "function": "Association analysis revealed associations between rs345476947 polymorphism in the FUT2 gene and the number of newborn piglets and weaned piglets., [RefSeq, PubMed]; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11132149, PubMed:7592879). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; FUT1 expression levels and low FUT2 expression levels in the intestines of Sutai pigs affected FUT1 and FUT2 enzymes, the synthesis of type 2 H and type 1 H antigens, and E. coli F18 adhesion. Moreover, low FUT2 expression levels conferred resistance to E. coli F18. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O19100;Q29044", "ec_number_list": "", "go_molecular_function": "GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 1540, "hit_score": 0.6, "record_id": "Q10982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q19AZ8-1", "uniprot_id": "THRB_PIG", "mass": 70066.0, "length": 623, "protein_name": "Prothrombin", "gene_name": "F2", "organism": "Pig", "refseq_name": "prothrombin precursor", "refseq_ac": "NP_001116457", "gene_names_uniprotkb": "F2", "gene_names_refseq": "F2", "protein_names_uniprotkb": "Prothrombin; 3.4.21.5; Coagulation factor II", "protein_names_refseq": "prothrombin precursor; prothrombin; thrombin", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144442)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14983233;18374141;19150392;19574550", "class_list": "", "function": "In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2, [RefSeq, PubMed]; The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model., [RefSeq, PubMed]; Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin., [RefSeq, PubMed]; Thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII and by receptor-mediated up-regulation of factor XIII synthesis, [RefSeq, PubMed]; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0006953 acute-phase response;GO:0030168 platelet activation;GO:0030194 positive regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q19AZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q19QT7-1", "uniprot_id": "CGL_PIG", "mass": 44490.0, "length": 405, "protein_name": "Cystathionine gamma-lyase", "gene_name": "CTH", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CTH", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystathionine gamma-lyase; 4.4.1.1; 4.4.1.2; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:733654)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16978188", "class_list": "", "function": "Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030170 pyridoxal phosphate binding;GO:0004123 cystathionine gamma-lyase activity;GO:0044540 L-cystine L-cysteine-lyase (deaminating);GO:0047982 homocysteine desulfhydrase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0019346 transsulfuration;GO:0019343 cysteine biosynthetic process via cystathionine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q19QT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q19S50-1", "uniprot_id": "STAT3_PIG", "mass": 88067.0, "length": 770, "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "organism": "Pig", "refseq_name": "signal transducer and activator of transcription 3", "refseq_ac": "NP_001038045", "gene_names_uniprotkb": "STAT3", "gene_names_refseq": "STAT3", "protein_names_uniprotkb": "Signal transducer and activator of transcription 3", "protein_names_refseq": "signal transducer and activator of transcription 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:733648); (R-SSC-1059683); (R-SSC-1266695); (R-SSC-1433557); (R-SSC-186763); (R-SSC-201556); (R-SSC-6783783); (R-SSC-6785807); (R-SSC-8849474); (R-SSC-8854691); (R-SSC-8875791); (R-SSC-8983432); (R-SSC-8984722); (R-SSC-8985947); (R-SSC-9008059); (R-SSC-9020933); (R-SSC-9020956); (R-SSC-9020958); (R-SSC-9701898); (R-SSC-9833482); (R-SSC-9958825)", "pathway_count": 21, "publication_count": 9, "publication_id_list": "16940292;18774104;20558729;21061196;26359029;27160867;27581515;29159507;31785377", "class_list": "", "function": "In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway, [RefSeq, PubMed]; Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group., [RefSeq, PubMed]; STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways, [RefSeq, PubMed]; STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning Publication Status: Online-Only, [RefSeq, PubMed]; SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway., [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The distribution of tyrosine phosphorylated signal transducer and activator of transcription 3., [RefSeq, PubMed]; This study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0001659 temperature homeostasis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q19S50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1W674-1", "uniprot_id": "HXK2_PIG", "mass": 102370.0, "length": 917, "protein_name": "Hexokinase-2", "gene_name": "HK2", "organism": "Pig", "refseq_name": "hexokinase-2", "refseq_ac": "NP_001116459", "gene_names_uniprotkb": "HK2", "gene_names_refseq": "HK2", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; HK II; Hexokinase type II", "protein_names_refseq": "HK II; hexokinase II; hexokinase type II; hexokinase-2; skeletal muscle hexokinase II", "tax_id": 9823, "disease": "", "pathway": " (ssc:494561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0006002 fructose 6-phosphate metabolic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1W674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1W675-1", "uniprot_id": "HMDH_PIG", "mass": 97151.0, "length": 885, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "gene_name": "HMGCR", "organism": "Pig", "refseq_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "refseq_ac": "NP_001116460", "gene_names_uniprotkb": "HMGCR; HMGR", "gene_names_refseq": "HMGCR; HMGR", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase; 1.1.1.34; HMG-CoA reductase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase", "tax_id": 9823, "disease": "", "pathway": " (ssc:100144446)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22240315;28017735;31212640", "class_list": "", "function": "Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis., [UniProtKB, UniProtKB]; HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage., [RefSeq, PubMed]; Porcine circovirus type 2 infection may enhance or maintain the level of phosphorylated HMGCR by directly interacting with the protein in PK-15 cells. Publication Status: Online-Only, [RefSeq, PubMed]; The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050661 NADP binding;GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0015936 coenzyme A metabolic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1W675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27HV0-1", "uniprot_id": "OGT1_PIG", "mass": 116923.0, "length": 1046, "protein_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "gene_name": "OGT", "organism": "Pig", "refseq_name": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "refseq_ac": "NP_001034837", "gene_names_uniprotkb": "OGT", "gene_names_refseq": "OGT", "protein_names_uniprotkb": "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; 2.4.1.255; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT", "protein_names_refseq": "O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "tax_id": 9823, "disease": "", "pathway": " (ssc:664652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26004176", "class_list": "", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (By similarity). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B. Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Ogt, Gfpt (glutamine-fructose-6-P aminotransferase), and Oga (O-GlcNAcase)., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006110 regulation of glycolytic process;GO:0016485 protein processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 5, "hit_score": 0.2, "record_id": "Q27HV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28832-1", "uniprot_id": "LDLR_PIG", "mass": 89920.0, "length": 811, "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "organism": "Pig", "refseq_name": "low-density lipoprotein receptor precursor", "refseq_ac": "NP_001193283", "gene_names_uniprotkb": "LDLR", "gene_names_refseq": "LDLR", "protein_names_uniprotkb": "Low-density lipoprotein receptor; LDL receptor", "protein_names_refseq": "LDL receptor; low-density lipoprotein receptor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396801)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10064736;16303770;19544207;24954195;38054618;8344216;9556295", "class_list": "", "function": "Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization., [UniProtKB, UniProtKB]; Found association between genotypes for LDLR and APOB polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms, [RefSeq, PubMed]; KLF13 and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor promoter function, [RefSeq, PubMed]; Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry., [RefSeq, PubMed]; The LDLR gene should be a candidate causative gene for LDL-cholesterol and total cholesterol in pigs, but heterogeneity exists in different populations., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O62817;O77619;Q9TV95", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0071813 lipoprotein particle binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0042632 cholesterol homeostasis;GO:0045056 transcytosis;GO:0090118 receptor-mediated endocytosis involved in cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q28832-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28833-1", "uniprot_id": "VWF_PIG", "mass": 272397.0, "length": 2482, "protein_name": "von Willebrand factor", "gene_name": "VWF", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VWF; F8VWF", "gene_names_refseq": "", "protein_names_uniprotkb": "von Willebrand factor; vWF", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12871266;8352759", "class_list": "", "function": "Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity)., [UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 12, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0033093 Weibel-Palade body", "go_biological_process": "GO:0007155 cell adhesion;GO:0007596 blood coagulation;GO:0030168 platelet activation;GO:0007599 hemostasis;GO:0031589 cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28833-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28938-1", "uniprot_id": "IL12B_PIG", "mass": 36829.0, "length": 324, "protein_name": "Interleukin-12 subunit beta", "gene_name": "IL12B", "organism": "Pig", "refseq_name": "interleukin-12 subunit beta precursor", "refseq_ac": "NP_999178", "gene_names_uniprotkb": "IL12B", "gene_names_refseq": "IL12B", "protein_names_uniprotkb": "Interleukin-12 subunit beta; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B", "protein_names_refseq": "CLMF p40; IL-12 subunit p40; IL-12B; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 p40 subunit; interleukin-12 subunit beta precursor; interleukin-12 subunit beta; interleukin-23 p40 subunit", "tax_id": 9823, "disease": "", "pathway": " (ssc:397076); (R-SSC-9020591); (R-SSC-9020933)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19520150;32881233;9239844", "class_list": "", "function": "Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)., [UniProtKB]; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC., [UniProtKB]; Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6, IL-12p40, IL-1beta, and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1., [RefSeq, PubMed]; IL-12p40 gene expression in lung and hilar lymph nodes of MPS-resistant pigs. Erratum:[Anim Sci J. 2020 Jan;91(1):e13470. doi: 10.1111/asj.13470. PMID: 33025671], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045519 interleukin-23 receptor binding;GO:0005143 interleukin-12 receptor binding;GO:0042164 interleukin-12 alpha subunit binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0070743 interleukin-23 complex;GO:0043514 interleukin-12 complex;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0032693 negative regulation of interleukin-10 production;GO:0032700 negative regulation of interleukin-17 production;GO:0032740 positive regulation of interleukin-17 production;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28942-1", "uniprot_id": "FCG3A_PIG", "mass": 29062.0, "length": 257, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor III-A", "gene_name": "FCGR3A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FCGR3A; FCGR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor III-A; Cytolytic trigger molecule G7; Fc-gamma RIII-alpha; Fc-gamma RIII; FcRIII; FcgammaRIIIA; IgG Fc receptor III-A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "31323052;34485821;8077673", "class_list": "", "function": "Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:31323052). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q28940;Q28941", "ec_number_list": "", "go_molecular_function": "GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0001788 antibody-dependent cellular cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q28942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28948-1", "uniprot_id": "AAPK2_PIG", "mass": 62325.0, "length": 552, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "organism": "Pig", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "refseq_ac": "NP_999431", "gene_names_uniprotkb": "PRKAA2; AMPK2", "gene_names_refseq": "AMPKA2; PRKAA2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-2; 2.7.11.1; 2.7.11.31; ACACA kinase; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-2; ACACA kinase; AMP-activated protein kinase alpha 2; AMPK subunit alpha-2; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase AMP-activated alpha 2 catalytic subunit", "tax_id": 9823, "disease": "", "pathway": " (ssc:397504); (R-SSC-1632852); (R-SSC-163680); (R-SSC-200425); (R-SSC-380972); (R-SSC-5628897); (R-SSC-6804756); (R-SSC-9759194); (R-SSC-9931269)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "19793316;7718624", "class_list": "", "function": "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (By similarity). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45/WIPI4. Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (By similarity). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (By similarity). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (By similarity). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Single SNP and haplotype analyses revealed weak associations between the PRKAA2 genotypes and loin muscle area in the investigated populations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YRX9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004679 AMP-activated protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030424 axon", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28948-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28969-1", "uniprot_id": "NOS3_PIG", "mass": 133406.0, "length": 1205, "protein_name": "Nitric oxide synthase 3", "gene_name": "NOS3", "organism": "Pig", "refseq_name": "nitric oxide synthase 3", "refseq_ac": "NP_999460", "gene_names_uniprotkb": "NOS3; NOS", "gene_names_refseq": "EC-NOS; NOS3; NOSIII; NOS; cNOS; eNOS", "protein_names_uniprotkb": "Nitric oxide synthase 3; 1.14.13.39; Constitutive NOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; Nitric oxide synthase, endothelial; cNOS; eNOS", "protein_names_refseq": "NOS type III; constitutive NOS; endothelial NOS; endothelial nitric oxide synthase; nitric oxide synthase 3; nitric oxide synthase, endothelial", "tax_id": 9823, "disease": "", "pathway": " (ssc:397557)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14729513;15191891;15333638;21844953;21970701;25380860;30439484;9149402", "class_list": "", "function": "Data suggest that pig sperm contain bNOS, iNOS, and eNOS; up-regulation of NOS by leptin during acrosome reaction and inhibition of acrosome reaction by inhibitors of nitric oxide synthases suggests these enzymes are involved in acrosome reaction. Publication Status: Online-Only, [RefSeq, PubMed]; ENOS protein and nitric oxide content in endothelial cells of conduit arteries is increased compared with the microcirculation endothelial cells., [RefSeq, PubMed]; Endothelium-derived NO stimulates guanylyl cyclase in vascular smooth muscle cells and, thereby, permits CO to cause dilation by activating K(Ca) channels, [RefSeq, PubMed]; Icariin and icariside II may increase the eNOS expression through activating EGF-EGFR pathway in porcine aortic endothelial cells., [RefSeq, PubMed]; NOS3 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest., [RefSeq, PubMed]; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity)., [UniProtKB, UniProtKB]; The inhibitory domain of eNOs stimulates vasodilation of the pulmonary artery., [RefSeq, PubMed]; The p38 MAPK is an upstream component of Akt-mediated eNOS activation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0042311 vasodilation;GO:0045776 negative regulation of blood pressure;GO:0007263 nitric oxide mediated signal transduction;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q28969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28983-1", "uniprot_id": "ZAN_PIG", "mass": 270365.0, "length": 2476, "protein_name": "Zonadhesin", "gene_name": "ZAN", "organism": "Pig", "refseq_name": "zonadhesin precursor", "refseq_ac": "NP_999548", "gene_names_uniprotkb": "ZAN", "gene_names_refseq": "ZAN", "protein_names_uniprotkb": "Zonadhesin", "protein_names_refseq": "zonadhesin precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397676)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7592795", "class_list": "", "function": "Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling., [UniProtKB]", "predicted_glycosites": 21, "predicted_n_glycosites": 18, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q28997-1", "uniprot_id": "ADRB2_PIG", "mass": 46760.0, "length": 418, "protein_name": "Beta-2 adrenergic receptor", "gene_name": "ADRB2", "organism": "Pig", "refseq_name": "beta-2 adrenergic receptor", "refseq_ac": "NP_001121908", "gene_names_uniprotkb": "ADRB2", "gene_names_refseq": "ADRB2", "protein_names_uniprotkb": "Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor", "protein_names_refseq": "adrenergic, beta-2-, receptor, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta-2-adrenergic receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397357)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10229356;17463060;19696365;20035031;25050597;25078038;27330078", "class_list": "", "function": "A persistent B2R-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA., [RefSeq, PubMed]; Beta(1)- and beta(2)-adrenoceptors contribute to the beta-feedforward coronary resistance vessel dilation during exercise., [RefSeq, PubMed]; G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (By similarity). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway. ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (By similarity). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release., [RefSeq, PubMed]; Prolactin infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway, [RefSeq, PubMed]; The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic., [RefSeq, PubMed]; These data collectively reveal the potential of beta2ARag to improve skin scarring., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O02779;Q6QTF6", "ec_number_list": "", "go_molecular_function": "GO:0051380 norepinephrine binding;GO:0004941 beta2-adrenergic receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q28997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29030-1", "uniprot_id": "SCF_PIG", "mass": 31119.0, "length": 274, "protein_name": "Kit ligand", "gene_name": "KITLG", "organism": "Pig", "refseq_name": "kit ligand precursor", "refseq_ac": "NP_999434", "gene_names_uniprotkb": "KITLG; MGF", "gene_names_refseq": "KITLG; KITL", "protein_names_uniprotkb": "Kit ligand; MGF; Mast cell growth factor; SCF; Stem cell factor; c-Kit ligand", "protein_names_refseq": "KIT ligand protein; MGF; SCF; c-kit ligand; kit ligand precursor; mast cell growth factor; stem cell factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397509)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12941156;16441305;17475461;17965540;18318788;7508758", "class_list": "", "function": "Dietary supplementation with zinc oxide inhibits expression in the small intestine., [RefSeq, PubMed]; KIT-KL might not be associated with the growth initiation of porcine primordial oocytes, although they do enhance the survival of the oocytes, [RefSeq, PubMed]; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins (By similarity)., [UniProtKB]; Little evidence was found for the KITLG gene being linked to variation in colour, [RefSeq, PubMed]; Oocyte-derived signals interact locally to mediate granulosa and theca cell function. SCF has a role in modulating this local interaction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2WG86", "ec_number_list": "", "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0045636 positive regulation of melanocyte differentiation;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q29030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29031-1", "uniprot_id": "MYC_PIG", "mass": 50088.0, "length": 452, "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "organism": "Pig", "refseq_name": "myc proto-oncogene protein", "refseq_ac": "NP_001005154", "gene_names_uniprotkb": "MYC", "gene_names_refseq": "MYC; c-Myc-a; c-Myc-b; c-Myc", "protein_names_uniprotkb": "Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64", "protein_names_refseq": "c-myc proto-oncogene; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog", "tax_id": 9823, "disease": "", "pathway": " (ssc:448810)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10442983;19738434;3277717;33994350", "class_list": "", "function": "Mir-34c affects the proliferation and pluripotency of porcine induced pluripotent stem cell (piPSC)-like cells by targeting c-Myc., [RefSeq, PubMed]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29031-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29043-1", "uniprot_id": "FUT1_PIG", "mass": 41106.0, "length": 365, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1", "gene_name": "FUT1", "organism": "Pig", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 1", "refseq_ac": "NP_999233", "gene_names_uniprotkb": "FUT1", "gene_names_refseq": "FUT1", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 1; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 1; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; alpha(1,2)FT 1; alpha-1,2-fucosyltransferase; alpha-1-fucosyltransferase; galactoside 2-alpha-L-fucosyltransferase 1; galactoside alpha-(1,2)-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397138); (R-SSC-9033807); (R-SSC-9840309)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11132149;12672664;16130473;24336113;25318177;26985939;30734380;32311589;8613146;9321466", "class_list": "", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; FUT1 expression levels and low FUT2 expression levels in the intestines of Sutai pigs affected FUT1 and FUT2 enzymes, the synthesis of type 2 H and type 1 H antigens, and E. coli F18 adhesion. Moreover, low FUT2 expression levels conferred resistance to E. coli F18. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic variability is assocated with reproductive traits., [RefSeq, PubMed]; Polymorphism of FUT1 and MUC4 associated with resistance to colibacteriosis was determined., [RefSeq, PubMed]; Polymorphism of the alpha-1-fucosyltransferase (FUT1) gene in several wild boar (Sus scrofa) populations in France and link to edema disease., [RefSeq, PubMed]; Results highlight the role of MUC4 and FUT1 on pig intestinal homoeostasis and improved the knowledge regarding the potential interaction between host genetics, gut microbiota composition and host metabolism in a healthy status., [RefSeq, PubMed]; The 5'-flanking region of the FUT1 gene (-1150 to +50 bp) exhibited promoter activity and the -1150-bp to -849-bp region showed negative regulation of the gene. Publication Status: Online-Only, [RefSeq, PubMed]; Transgenic male pigs were produced that possess an alpha alpha-1,3-galactosyltransferase knockout allele and express a randomly inserted human alpha 1,2-fucosylosyltransferase transgene, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O19101", "ec_number_list": "", "go_molecular_function": "GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration", "synthesized_glycan_count": 1540, "hit_score": 1.1, "record_id": "Q29043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29048-1", "uniprot_id": "VATA_PIG", "mass": 68318.0, "length": 617, "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "organism": "Pig", "refseq_name": "V-type proton ATPase catalytic subunit A", "refseq_ac": "NP_001004042", "gene_names_uniprotkb": "ATP6V1A; ATP6A1; ATP6V1A1", "gene_names_refseq": "ATP6A1; ATP6V1A1; ATP6V1A", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A; 7.1.2.2; V-ATPase 69 kDa subunit; V-ATPase subunit A; Vacuolar proton pump subunit alpha", "protein_names_refseq": "H+ ATPase; V-ATPase 69 kDa subunit; V-ATPase subunit A; V-type proton ATPase catalytic subunit A; Vacuolar ATP synthase catalytic subunit A; vacuolar proton pump subunit alpha", "tax_id": 9823, "disease": "", "pathway": " (ssc:445531)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1420264", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment. The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0046034 ATP metabolic process;GO:0036295 cellular response to increased oxygen levels;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29092-1", "uniprot_id": "ENPL_PIG", "mass": 92471.0, "length": 804, "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "organism": "Pig", "refseq_name": "endoplasmin precursor", "refseq_ac": "NP_999268", "gene_names_uniprotkb": "HSP90B1; GRP94; HSPC4; TRA1", "gene_names_refseq": "GRP94; Gp96; HSP90B1; TRA1; ppk98", "protein_names_uniprotkb": "Endoplasmin; 3.6.4.-; 94 kDa glucose-regulated protein; 98 kDa protein kinase; GRP-94; Heat shock protein 90 kDa beta member 1; PPK 98; gp96 homolog; ppk98", "protein_names_refseq": "94 kDa glucose-regulated protein; 98 kDa protein kinase; Endoplasmin; GRP-94; PPK 98; endoplasmin precursor; gp96 homolog; heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; tumor rejection antigen (gp96) 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397191)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15236592;16731965;7957217;9407008", "class_list": "", "function": "ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Structural maturation of the client protein substrate, rather than ATP binding or hydrolysis, serves as the primary signal for dissociation of GRP94-client protein complexes [GRP94], [RefSeq, PubMed]; These results identify a compact, intertwined quaternary conformation of native GRP94, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O19070;Q29091", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0042470 melanosome;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29101-1", "uniprot_id": "CXA1_PIG", "mass": 43049.0, "length": 382, "protein_name": "Gap junction alpha-1 protein", "gene_name": "GJA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GJA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15083360;8832399", "class_list": "", "function": "Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis. May play a role in cell growth inhibition through the regulation of NOV expression and localization (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TYA4", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding;GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29116-1", "uniprot_id": "TENA_PIG", "mass": 191400.0, "length": 1746, "protein_name": "Tenascin", "gene_name": "TNC", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TNC; HXB", "gene_names_refseq": "", "protein_names_uniprotkb": "Tenascin; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; P230; TN-C; TN; Tenascin-C", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:397460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1722152;9498558", "class_list": "", "function": "Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "P98142", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0098966 perisynaptic extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29116-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29121-1", "uniprot_id": "GALT1_PIG", "mass": 64119.0, "length": 559, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 1", "gene_name": "GALNT1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GALNT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 1; 2.4.1.41; GalNAc-T1; Polypeptide GalNAc transferase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8748160", "class_list": "", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8748160). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "Q29121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29243-1", "uniprot_id": "DAG1_PIG", "mass": 95431.0, "length": 877, "protein_name": "Dystroglycan 1", "gene_name": "DAG1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DAG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dystroglycan 1; Dystroglycan; Dystrophin-associated glycoprotein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8672129", "class_list": "", "function": "Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. As a receptor for laminin is involved in extracellular matrix assembly, and activation of the PI3K/AKT pathway regulating cell apoptotic signals in muscle (By similarity). Binding of laminin LAMA1 to alpha-dystroglycan also initiates a signaling cascade in which Src kinases, c-Src or c-Fyn, phosphorylate syntrophin modifying its interaction with the adapter protein GRB2; this triggers recruitment of guanyl-nucleotide exchange factor SOS1 and activation of RAC1, finally resulting in c-Jun phosphorylation by MAPK8/JNK1 (By similarity). As a receptor for laminin LAMA1 is also involved in epithelium branching morphogenesis in salivary glang and lung (By similarity). Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (By similarity). Also acts as a receptor for laminin LAMA5 (By similarity). In muscle cells, it is a receptor for laminin-1 (also known as laminin-111 or EHS laminin) and is involved in the stimulation of agrin-induced acetylcholine receptor (AChR) clustering, and formation of the synaptic basement membrane. It is required for acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) through its binding with perlecan (HSPG2) and is, therefore, involved in the down-regulation of colinergic synaptic transmission (By similarity). In the retina, it is required for the formation of photoreceptor ribbon synapses through its interaction with pikachurin (EGFLAM) (By similarity). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis (By similarity). Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells (By similarity). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 4, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "I3LD20", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043236 laminin binding;GO:0005055 laminin receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0045211 postsynaptic membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0035022 positive regulation of Rac protein signal transduction;GO:0021675 nerve development;GO:0007411 axon guidance;GO:0002009 morphogenesis of an epithelium;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29243-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29261-1", "uniprot_id": "VILI_PIG", "mass": 92701.0, "length": 827, "protein_name": "Villin-1", "gene_name": "VIL1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VIL1; VIL", "gene_names_refseq": "", "protein_names_uniprotkb": "Villin-1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "14681463;8672129", "class_list": "", "function": "Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0001726 ruffle;GO:0005902 microvillus", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061041 regulation of wound healing;GO:0051125 regulation of actin nucleation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29411-1", "uniprot_id": "CH3L1_PIG", "mass": 42800.0, "length": 383, "protein_name": "Chitinase-3-like protein 1", "gene_name": "CHI3L1", "organism": "Pig", "refseq_name": "chitinase-3-like protein 1 precursor", "refseq_ac": "NP_001001540", "gene_names_uniprotkb": "CHI3L1", "gene_names_refseq": "CHI3L1; GP38K", "protein_names_uniprotkb": "Chitinase-3-like protein 1; 38 kDa heparin-binding glycoprotein; Signal-processing protein; gp38k", "protein_names_refseq": "38 kDa heparin-binding glycoprotein; chitinase-3-like protein 1 precursor; chitinase-3-like protein 1; signal-processing protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:396865)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12799184;3086326;7768902", "class_list": "", "function": "Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5UC99", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0034612 response to tumor necrosis factor;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29548-1", "uniprot_id": "HEXB_PIG", "mass": 61050.0, "length": 531, "protein_name": "Beta-hexosaminidase subunit beta", "gene_name": "HEXB", "organism": "Pig", "refseq_name": "beta-hexosaminidase subunit beta precursor", "refseq_ac": "NP_999086", "gene_names_uniprotkb": "HEXB", "gene_names_refseq": "HEXB", "protein_names_uniprotkb": "Beta-hexosaminidase subunit beta; 3.2.1.52; 65 kDa epididymal boar protein; Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta", "protein_names_refseq": "65 kDa epididymal boar protein; N-acetyl-beta-glucosaminidase subunit beta; beta-N-acetylhexosaminidase subunit beta; beta-hexosaminidase subunit beta precursor; beta-hexosaminidase subunit beta; hexosaminidase subunit B", "tax_id": 9823, "disease": "", "pathway": " (ssc:396958)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8902205", "class_list": "", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0060473 cortical granule", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization;GO:0030203 glycosaminoglycan metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29549-1", "uniprot_id": "CLUS_PIG", "mass": 51775.0, "length": 446, "protein_name": "Clusterin", "gene_name": "CLU", "organism": "Pig", "refseq_name": "clusterin precursor", "refseq_ac": "NP_999136", "gene_names_uniprotkb": "CLU", "gene_names_refseq": "CLU", "protein_names_uniprotkb": "Clusterin; CLI; CP40; Complement cytolysis inhibitor", "protein_names_refseq": "CLI; CP40; clusterin precursor; complement cytolysis inhibitor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397025); (R-SSC-114608); (R-SSC-166665); (R-SSC-6803157); (R-SSC-977606)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "1544909;17960512;18462614;20636542;9175781", "class_list": "", "function": "Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59., [RefSeq, PubMed]; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Porcine spermatozoa may delivery CLU, PRM1 and PRM2 mRNAs to the oocyte, which may contribute to zygotic and early embryonic development., [RefSeq, PubMed]; These results show that clusterin expression in porcine species is found in an own, as yet unidentified cell type during postnatal developmental stages., [RefSeq, PubMed]; This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051787 misfolded protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0002434 immune complex clearance;GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q29549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29550-1", "uniprot_id": "EST1_PIG", "mass": 62016.0, "length": 566, "protein_name": "Liver carboxylesterase", "gene_name": "", "organism": "Pig", "refseq_name": "liver carboxylesterase precursor", "refseq_ac": "NP_001302695", "gene_names_uniprotkb": "", "gene_names_refseq": "LOC100736962; PLE-1; PLE-G2", "protein_names_uniprotkb": "Liver carboxylesterase; 3.1.1.1; Proline-beta-naphthylamidase; REH; Retinyl ester hydrolase", "protein_names_refseq": "carboxylesterase; liver carboxylesterase 1; liver carboxylesterase G2; liver carboxylesterase precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:100736962)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16223870;1959668;31664043;9490062;9799112", "class_list": "", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Active towards triacylglycerides containing short-chain fatty acids from C2 to C6, and 1(3)-monoacylglycerols containing fatty acids from C2 to C12. Inactive on long-chain triacylglycerols and diacylglycerol. Hydrolyzes aromatic and alkyl esters and vitamin A acetate. The hydrolysis rate depends upon the amino acid promoiety and the esterification site of the prodrug. Aromatic promoieties are favored, highest rates are observed with phenylalanyl progdrugs, hydrolysis of valyl and isoleucyl prodrugs is less efficient. With floxuridine prodrugs, activity is higher on 5' monoesters than on 3' monoesters. With gemcitabine prodrugs, activity is higher on 3' monoesters than on 5' monoesters., [UniProtKB, PubMed, PubMed, PubMed]; Pig liver esterases PLE1 and PLE6: heterologous expression, hydrolysis of common antibiotics and pharmacological consequences. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97582;P82128", "ec_number_list": "", "go_molecular_function": "GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q29550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29552-1", "uniprot_id": "C11B1_PIG", "mass": 57340.0, "length": 503, "protein_name": "Cytochrome P450 11B1, mitochondrial", "gene_name": "CYP11B1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CYP11B1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 11B1, mitochondrial; 1.14.15.4; 1.14.15.5; CYPXIB1; Cytochrome P450C11; Steroid 11-beta-hydroxylase, CYP11B1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7696143", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone and other adrenal corticoids. Differing from other species (such as human, rat and mice), it is able to catalyze three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates, and ending with the formation of aldosterone. Steroid 11beta, 18- and 19-hydroxylase. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0032342 aldosterone biosynthetic process;GO:0034650 cortisol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q29599-1", "uniprot_id": "OAS1_PIG", "mass": 40246.0, "length": 349, "protein_name": "2'-5'-oligoadenylate synthase 1", "gene_name": "OAS1", "organism": "Pig", "refseq_name": "2'-5'-oligoadenylate synthase 1", "refseq_ac": "NP_999468", "gene_names_uniprotkb": "OAS1", "gene_names_refseq": "OAS1", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 1; (2-5')oligo(A) synthase 1; 2-5A synthase 1; 2.7.7.84; p42 OAS", "protein_names_refseq": "(2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase; 2'-5'-oligoadenylate synthase 1; 2-5A synthase 1; 2-5A synthetase 1; p42 OAS", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "14636576;18510738;18604630;20844035;8672129", "class_list": "", "function": "Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L (PubMed:20844035). Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis. Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms., [UniProtKB, UniProtKB, PubMed]; The active sites of OAS and CCA class I enzymes are highly conserved., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77734", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0060700 regulation of ribonuclease activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q29599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2HWD6-1", "uniprot_id": "KIT_PIG", "mass": 109135.0, "length": 972, "protein_name": "Mast/stem cell growth factor receptor Kit", "gene_name": "KIT", "organism": "Pig", "refseq_name": "mast/stem cell growth factor receptor Kit precursor", "refseq_ac": "NP_001037990", "gene_names_uniprotkb": "KIT", "gene_names_refseq": "KIT; MGF", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor Kit; 2.7.10.1; Proto-oncogene c-Kit; SCFR; Tyrosine-protein kinase Kit", "protein_names_refseq": "SCFR; c-kit; mast/stem cell growth factor receptor Kit precursor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit", "tax_id": 9823, "disease": "", "pathway": " (ssc:396810)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16734703;24628300;25788205;25959676;29338902;29485917", "class_list": "", "function": "A simple, rapid method, with high specificity and stability, for the detection of the KIT genotype in pigs was established using TaqMan MGB probe real-time quantitative PCR., [RefSeq, PubMed]; Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction., [RefSeq, PubMed]; It appears that the KIT gene would not be a major causal gene for melanoma development in pig, its genetic variation could be influencing this trait. Of 10 coding SNPs, three were non-synonymous mutations, likely to affect the protein conformation., [RefSeq, PubMed]; MRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals., [RefSeq, PubMed]; Mutational analysis of the KIT loci in relation to coat color., [RefSeq, PubMed]; These results suggest that DDX4 and c-kit are putative markers of undifferentiated spermatogonia in the prepubertal porcine testis., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity)., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0035162 embryonic hemopoiesis;GO:0038093 Fc receptor signaling pathway;GO:0006954 inflammatory response;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2HWD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2HYU2-1", "uniprot_id": "PFKAM_PIG", "mass": 85327.0, "length": 780, "protein_name": "ATP-dependent 6-phosphofructokinase, muscle type", "gene_name": "PFKM", "organism": "Pig", "refseq_name": "ATP-dependent 6-phosphofructokinase, muscle type", "refseq_ac": "NP_001038015", "gene_names_uniprotkb": "PFKM", "gene_names_refseq": "ATP-PFK; PFK-M; PFKM; PFMK", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, muscle type; 2.7.1.11; 6-phosphofructokinase type A; ATP-PFK; PFK-A; PFK-M; Phosphofructo-1-kinase isozyme A; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; PFK-A; muscle 6-phosphofructokinase; muscle phosphofructokinase; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase-M; phosphohexokinase", "tax_id": 9823, "disease": "", "pathway": " (ssc:733601)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HYU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2PKF4-1", "uniprot_id": "GNAQ_PIG", "mass": 42142.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein G(q) subunit alpha", "gene_name": "GNAQ", "organism": "Pig", "refseq_name": "guanine nucleotide-binding protein G(q) subunit alpha", "refseq_ac": "NP_001033712", "gene_names_uniprotkb": "GNAQ", "gene_names_refseq": "GNAQ", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(q) subunit alpha; 3.6.5.-; Guanine nucleotide-binding protein alpha-q", "protein_names_refseq": "guanine nucleotide-binding protein G(q) alpha subunit; guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein alpha-q", "tax_id": 9823, "disease": "", "pathway": " (ssc:654405); (R-SSC-112043); (R-SSC-202040); (R-SSC-399997); (R-SSC-416476); (R-SSC-418592); (R-SSC-428930); (R-SSC-434316); (R-SSC-456926); (R-SSC-6814122); (R-SSC-9856530); (R-SSC-9860927)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "18330691;27330078", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic., [RefSeq, PubMed]; The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0010543 regulation of platelet activation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2PKF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2QLE2-1", "uniprot_id": "CAV2_PIG", "mass": 18056.0, "length": 162, "protein_name": "Caveolin-2", "gene_name": "CAV2", "organism": "Pig", "refseq_name": "caveolin-2", "refseq_ac": "NP_001116563", "gene_names_uniprotkb": "CAV2", "gene_names_refseq": "CAV2", "protein_names_uniprotkb": "Caveolin-2", "protein_names_refseq": "caveolin-2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100125375); (R-SSC-9009391)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12917688;23826261", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity)., [UniProtKB]; MiR-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42, in intestinal Salmonella infection, is reported. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005925 focal adhesion;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2QLE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VIU1-1", "uniprot_id": "ID2_PIG", "mass": 14863.0, "length": 134, "protein_name": "DNA-binding protein inhibitor ID-2", "gene_name": "ID2", "organism": "Pig", "refseq_name": "DNA-binding protein inhibitor ID-2", "refseq_ac": "NP_001033054", "gene_names_uniprotkb": "ID2", "gene_names_refseq": "ID2", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-2; Inhibitor of DNA binding 2; Inhibitor of differentiation 2", "protein_names_refseq": "DNA-binding protein inhibitor ID-2; inhibitor of DNA binding 2, HLH protein; inhibitor of differentiation 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:654298)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0044325 transmembrane transporter binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000791 euchromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061031 endodermal digestive tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2VIU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VJ60-1", "uniprot_id": "RN19A_PIG", "mass": 90839.0, "length": 838, "protein_name": "E3 ubiquitin-protein ligase RNF19A", "gene_name": "RNF19A", "organism": "Pig", "refseq_name": "E3 ubiquitin-protein ligase RNF19A", "refseq_ac": "NP_001033095", "gene_names_uniprotkb": "RNF19A; RNF19", "gene_names_refseq": "RFN19; RNF19A; RNF19", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF19A; 2.3.2.31; Dorfin; Double ring-finger protein; RING finger protein 19A", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF19A; dorfin; double ring-finger protein; ring finger protein 19", "tax_id": 9823, "disease": "", "pathway": " (ssc:654326); (R-SSC-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22760261", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR., [UniProtKB]; Porcine RNF19 gene maps to chromosome 4 (4p11-p12), consistent with the currently known conservation of genome organization between human and pig., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2VJ61", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2VJ60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VL90-1", "uniprot_id": "C163A_PIG", "mass": 120456.0, "length": 1115, "protein_name": "Scavenger receptor cysteine-rich type 1 protein M130", "gene_name": "CD163", "organism": "Pig", "refseq_name": "scavenger receptor cysteine-rich type 1 protein M130 precursor", "refseq_ac": "NP_999141", "gene_names_uniprotkb": "CD163; M130", "gene_names_refseq": "CD163", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich type 1 protein M130", "protein_names_refseq": "scavenger receptor cysteine-rich type 1 protein M130 precursor; scavenger receptor cysteine-rich type 1 protein M130", "tax_id": 9823, "disease": "", "pathway": " (ssc:397031)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14648288;15481141;19939927;31174697;31282367;31440241;31558095;35506985", "class_list": "", "function": "After shedding, the soluble form (sCD163) may play an anti-inflammatory role., [UniProtKB]; Generation of CD163-edited pig via electroporation of the CRISPR/Cas9 system into porcine in vitro-fertilized zygotes., [RefSeq, PubMed]; Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry., [UniProtKB, PubMed]; Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS)., [RefSeq, PubMed]; The expression of TLR2, Siglec-3 and CD163 on peripheral blood monocytes is significantly higher during H. parasuis-induced sepsis than before infection., [RefSeq, PubMed]; The frequency and median fluorescence intensity (MFI) of CD163 within pulmonary alveolar macrophages were much lower in porcine reproductive and respiratory syndrome virus Lena-infected pigs than in 3249-infected pigs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2VL89;Q8HY22", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q2VL90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZD69-1", "uniprot_id": "LMNA_PIG", "mass": 74219.0, "length": 664, "protein_name": "Prelamin-A/C", "gene_name": "LMNA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LMNA", "gene_names_refseq": "", "protein_names_uniprotkb": "Prelamin-A/C", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2980766); (R-SSC-2995383); (R-SSC-352238); (R-SSC-4419969)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals. Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis., [UniProtKB, UniProtKB]; Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZD68", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0160123 structural constituent of nuclear lamina", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005882 intermediate filament;GO:0016363 nuclear matrix", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0034504 protein localization to nucleus;GO:0090398 cellular senescence;GO:0006998 nuclear envelope organization;GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZD69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZDQ5-1", "uniprot_id": "CAV3_PIG", "mass": 17367.0, "length": 151, "protein_name": "Caveolin-3", "gene_name": "CAV3", "organism": "Pig", "refseq_name": "caveolin-3", "refseq_ac": "NP_001032226", "gene_names_uniprotkb": "CAV3", "gene_names_refseq": "CAV3; Caveolin-3", "protein_names_uniprotkb": "Caveolin-3", "protein_names_refseq": "caveolin-3", "tax_id": 9823, "disease": "", "pathway": " (ssc:641358)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16750814", "class_list": "", "function": "Cloned and characterized caveolin-3 from porcine muscle; caveolin-3 was expressed specifically in skeletal muscle & heart; first evidence that caveolin-3 has a certain regulated expression pattern during the prenatal period of skeletal muscle development, [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15G23", "ec_number_list": "", "go_molecular_function": "GO:0071253 connexin binding;GO:0060090 molecular adaptor activity;GO:0005246 calcium channel regulator activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0060299 negative regulation of sarcomere organization;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0090279 regulation of calcium ion import;GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZDQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4A1L5-1", "uniprot_id": "BECN1_PIG", "mass": 51759.0, "length": 448, "protein_name": "Beclin-1", "gene_name": "BECN1", "organism": "Pig", "refseq_name": "beclin-1", "refseq_ac": "NP_001037995", "gene_names_uniprotkb": "BECN1; ATG6", "gene_names_refseq": "ATG6; BECN1", "protein_names_uniprotkb": "Beclin-1", "protein_names_refseq": "beclin-1", "tax_id": 9823, "disease": "", "pathway": " (ssc:733576)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23056260;23228131;29698908", "class_list": "", "function": "A study of the expression of BECN1, LC3-II, and LAMP1 throughout the luteal phase of the estrous cycle in order to assess autophagy during corpus luteum development is reported., [RefSeq, PubMed]; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that the expression of MAP1LC3A, B and autophagy-associated genes (ATG5, mTOR, Beclin-1) was increased in normal pigs, while decreased in miniature pigs., [RefSeq, PubMed]; Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0051301 cell division;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4A1L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4U116-1", "uniprot_id": "S4A4_PIG", "mass": 121410.0, "length": 1079, "protein_name": "Electrogenic sodium bicarbonate cotransporter 1", "gene_name": "SLC4A4", "organism": "Pig", "refseq_name": "electrogenic sodium bicarbonate cotransporter 1", "refseq_ac": "NP_001025704", "gene_names_uniprotkb": "SLC4A4; NBC1; NBCE1", "gene_names_refseq": "NBC1; NBCE1; SLC4A4", "protein_names_uniprotkb": "Electrogenic sodium bicarbonate cotransporter 1; Na(+)/HCO3(-) cotransporter; Sodium bicarbonate cotransporter; Solute carrier family 4 member 4", "protein_names_refseq": "Na(+)/HCO3(-) cotransporter; electrogenic sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter member 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:503546)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12225967", "class_list": "", "function": "Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4U115;Q5EC51;Q5EC52;Q864R7", "ec_number_list": "", "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006814 sodium ion transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4U116-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52NJ2-1", "uniprot_id": "RAB1A_PIG", "mass": 22606.0, "length": 205, "protein_name": "Ras-related protein Rab-1A", "gene_name": "RAB1A", "organism": "Pig", "refseq_name": "ras-related protein Rab-1A", "refseq_ac": "NP_001026957", "gene_names_uniprotkb": "RAB1A", "gene_names_refseq": "RAB1A; RAB1B", "protein_names_uniprotkb": "Ras-related protein Rab-1A; 3.6.5.2", "protein_names_refseq": "RAB1B, member RAS oncogene family; ras-related protein Rab-1A", "tax_id": 9823, "disease": "", "pathway": " (ssc:595116)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29128753", "class_list": "", "function": "HostrRab1A is required for classical swine fever virus particle assembly and binds to viral particle assembly-related NS5A protein., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Required to modulate the compacted morphology of the Golgi (By similarity). Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016477 cell migration;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q52NJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q59HI8-1", "uniprot_id": "Q59HI8_PIG", "mass": 89639.0, "length": 785, "protein_name": "Toll-like receptor 2", "gene_name": "TLR2", "organism": "Pig", "refseq_name": "toll-like receptor 2 isoform X1", "refseq_ac": "XP_005653633", "gene_names_uniprotkb": "TLR2", "gene_names_refseq": "TLR2", "protein_names_uniprotkb": "Toll-like receptor 2", "protein_names_refseq": "toll-like receptor 2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1461957); (R-SSC-5686938); (R-SSC-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AZK0;A0A8D0TKU7", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0042497 triacyl lipopeptide binding;GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0044853 plasma membrane raft", "go_biological_process": "GO:1904466 positive regulation of matrix metallopeptidase secretion;GO:0006954 inflammatory response;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q59HI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5CD18-1", "uniprot_id": "TGFR1_PIG", "mass": 56174.0, "length": 503, "protein_name": "TGF-beta receptor type-1", "gene_name": "TGFBR1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFBR1", "gene_names_refseq": "", "protein_names_uniprotkb": "TGF-beta receptor type-1; 2.7.11.30; TGF-beta receptor type I; TGF-beta type I receptor; TGFR-1; TbetaR-I; Transforming growth factor-beta receptor type I", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:396665)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16341765", "class_list": "", "function": "Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5CD19", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0016361 activin receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0007399 nervous system development;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5CD18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5D891-1", "uniprot_id": "PK3C3_PIG", "mass": 101234.0, "length": 887, "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "organism": "Pig", "refseq_name": "phosphatidylinositol 3-kinase catalytic subunit type 3", "refseq_ac": "NP_001012974", "gene_names_uniprotkb": "PIK3C3", "gene_names_refseq": "PIK3C3", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase catalytic subunit type 3; 2.7.1.137; PI3-kinase type 3; PI3K type 3; Phosphoinositide-3-kinase class 3; PtdIns-3-kinase type 3", "protein_names_refseq": "PI3-kinase type 3; PI3K type 3; class 3 phosphoinositide-3-kinase; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; ptdIns-3-kinase type 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:503700)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15628029;21269358;24128088", "class_list": "", "function": "Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs, [RefSeq, PubMed]; These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome;GO:0016020 membrane;GO:0005770 late endosome", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0006897 endocytosis;GO:0051301 cell division;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5D891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5EE05-1", "uniprot_id": "ABHD5_PIG", "mass": 39004.0, "length": 349, "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5", "gene_name": "ABHD5", "organism": "Pig", "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5", "refseq_ac": "NP_001012407", "gene_names_uniprotkb": "ABHD5", "gene_names_refseq": "ABHD5; CGI-58", "protein_names_uniprotkb": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 2.3.1.51; Abhydrolase domain-containing protein 5", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain-containing protein 5; alpha/beta hydrolase domain-containing 5; lipid droplet binding protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:497624)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22829614", "class_list": "", "function": "Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These findings suggest that CGI-58 may be a new target for enhancing the quality of pork products as well as offering the potential of CGI-58 for human obesity treatment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0030154 cell differentiation;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EE05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GN48-1", "uniprot_id": "DMD_PIG", "mass": 424858.0, "length": 3674, "protein_name": "Dystrophin", "gene_name": "DMD", "organism": "Pig", "refseq_name": "dystrophin", "refseq_ac": "NP_001012408", "gene_names_uniprotkb": "DMD", "gene_names_refseq": "DMD", "protein_names_uniprotkb": "Dystrophin", "protein_names_refseq": "dystrophin", "tax_id": 9823, "disease": "", "pathway": " (ssc:497636)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15941659;24347611;34884867", "class_list": "", "function": "A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping. Publication Status: Online-Only, [RefSeq, PubMed]; Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission., [UniProtKB, UniProtKB]; Data indicate that skeletal muscles from with a missense mutation in the dystrophin gene is associated with muscle histophatology., [RefSeq, PubMed]; This study suggested thatdystrophins are expressed in the outer plexiform layer, around blood vessels and at the inner limiting membrane as previously described in human and mouse retinae., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0045211 postsynaptic membrane;GO:0042383 sarcolemma;GO:0030016 myofibril", "go_biological_process": "GO:0048666 neuron development;GO:0007519 skeletal muscle tissue development;GO:0055001 muscle cell development;GO:0090257 regulation of muscle system process;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5GN48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I2M3-1", "uniprot_id": "TLR9_PIG", "mass": 115883.0, "length": 1030, "protein_name": "Toll-like receptor 9", "gene_name": "TLR9", "organism": "Pig", "refseq_name": "toll-like receptor 9 precursor", "refseq_ac": "NP_999123", "gene_names_uniprotkb": "TLR9", "gene_names_refseq": "TLR9", "protein_names_uniprotkb": "Toll-like receptor 9", "protein_names_refseq": "toll-like receptor 9 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397007); (R-SSC-109704); (R-SSC-1679131); (R-SSC-168138)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15607737;28757040;29555549;30548974;32173534;38636174", "class_list": "", "function": "Endotracheal tube presence was characterized by neutrophil activation, necrosis, and release of proinflammatory cytokines mediated by TLR9/NF-kappaB induction., [RefSeq, PubMed]; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling., [RefSeq, PubMed]; Porcine parvovirus virus infection significantly induced IL-6 expression and this induction depended on NF-kappaB activation and TLR9 signaling pathways in PK-15 cell., [RefSeq, PubMed]; TLR9 mediates IgA production in the porcine small intestine during PEDV infection., [RefSeq, PubMed]; These results indicate clear responses of porcine neonatal antigen presenting cells after TLR2 and TLR9 stimulation, [RefSeq, PubMed]; Toll-like receptor 9 expressed in proximal intestinal enteroendocrine cells detects bacteria resulting in secretion of cholecystokinin., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035197 siRNA binding;GO:0045322 unmethylated CpG binding;GO:0005149 interleukin-1 receptor binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0032727 positive regulation of interferon-alpha production;GO:0032741 positive regulation of interleukin-18 production;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5I2M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5MNU5-1", "uniprot_id": "SCAP_PIG", "mass": 140058.0, "length": 1279, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "SCAP", "organism": "Pig", "refseq_name": "sterol regulatory element-binding protein cleavage-activating protein", "refseq_ac": "NP_001185623", "gene_names_uniprotkb": "SCAP", "gene_names_refseq": "SCAP", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein", "protein_names_refseq": "SREBP cleavage activating protein; sterol regulatory element-binding protein cleavage-activating protein; sterol response element binding protein cleavage-activating protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:494015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16705418", "class_list": "", "function": "Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0R5S1;Q0R5S2;Q3SBD2;Q5I387;Q5MJG7;Q5QCZ6;Q6VFU0", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0008203 cholesterol metabolic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5MNU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5W9D5-1", "uniprot_id": "QKI_PIG", "mass": 37671.0, "length": 341, "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "QKI", "organism": "Pig", "refseq_name": "KH domain-containing RNA-binding protein QKI", "refseq_ac": "NP_001007196", "gene_names_uniprotkb": "QKI", "gene_names_refseq": "PqkI; QKI", "protein_names_uniprotkb": "KH domain-containing RNA-binding protein QKI; PqkI; Protein quaking", "protein_names_refseq": "KH domain-containing RNA-binding protein QKI; QKI, KH domain containing, RNA binding tv1; protein quaking; quaking homolog, KH domain RNA binding; quaking protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:492277)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16147890;25786081", "class_list": "", "function": "MiR-499 was negatively correlated to the expression of QKI in testicular tissue., [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0048255 mRNA stabilization;GO:0017148 negative regulation of translation;GO:0045650 negative regulation of macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5W9D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66T47-1", "uniprot_id": "AVR2B_PIG", "mass": 57693.0, "length": 512, "protein_name": "Activin receptor type-2B", "gene_name": "ACVR2B", "organism": "Pig", "refseq_name": "activin receptor type-2B precursor", "refseq_ac": "NP_001005350", "gene_names_uniprotkb": "ACVR2B", "gene_names_refseq": "ACVR2B", "protein_names_uniprotkb": "Activin receptor type-2B; 2.7.11.30; ACTR-IIB; Activin receptor type IIB", "protein_names_refseq": "ACTR-IIB; activin receptor type IIB; activin receptor type-2B precursor; activin receptor type-2B; testicular activin receptor IIB", "tax_id": 9823, "disease": "", "pathway": " (ssc:448845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048185 activin binding;GO:0017002 activin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex", "go_biological_process": "GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66T47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68J42-1", "uniprot_id": "LIPS_PIG", "mass": 83450.0, "length": 764, "protein_name": "Hormone-sensitive lipase", "gene_name": "LIPE", "organism": "Pig", "refseq_name": "hormone-sensitive lipase", "refseq_ac": "NP_999480", "gene_names_uniprotkb": "LIPE", "gene_names_refseq": "HSL; LIPE; REH", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; HSL; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase; monoacylglycerol lipase LIPE; retinyl ester hydrolase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397583)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10050278", "class_list": "", "function": "Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (By similarity). Shows a preferential hydrolysis of DAGs over TAGs and MAGs (By similarity). Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q68J43;Q9TUK0;Q9TUK1", "ec_number_list": "", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0016042 lipid catabolic process;GO:0046340 diacylglycerol catabolic process;GO:0019433 triglyceride catabolic process;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68J42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68Y56-1", "uniprot_id": "TLR4_PIG", "mass": 96309.0, "length": 841, "protein_name": "Toll-like receptor 4", "gene_name": "TLR4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TLR4", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor 4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001530 lipopolysaccharide binding;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0001726 ruffle;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0032731 positive regulation of interleukin-1 beta production;GO:0032680 regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68Y56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GWX0-1", "uniprot_id": "DDX4_PIG", "mass": 78810.0, "length": 722, "protein_name": "Probable ATP-dependent RNA helicase DDX4", "gene_name": "DDX4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DDX4; VASA", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX4; 3.6.4.13; DEAD box protein 4; Vasa homolog; Vasa-like protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0071546 pi-body;GO:0033391 chromatoid body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007281 germ cell development;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6GWX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PLK3-1", "uniprot_id": "AOFB_PIG", "mass": 58265.0, "length": 520, "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "MAOB", "organism": "Pig", "refseq_name": "amine oxidase [flavin-containing] B", "refseq_ac": "NP_001001864", "gene_names_uniprotkb": "MAOB", "gene_names_refseq": "MAOB", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] B; 1.4.3.21; 1.4.3.4; MAO-B; Monoamine oxidase type B", "protein_names_refseq": "MAO-B; amine oxidase [flavin-containing] B; monoamine oxidase type B", "tax_id": 9823, "disease": "", "pathway": " (ssc:414909)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16147870", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine., [UniProtKB, UniProtKB]; Cloning and characterization of monoamine oxidase A and B genes in pig, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PLK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PQD5-1", "uniprot_id": "ATM_PIG", "mass": 350564.0, "length": 3057, "protein_name": "Serine-protein kinase ATM", "gene_name": "ATM", "organism": "Pig", "refseq_name": "serine-protein kinase ATM", "refseq_ac": "NP_001116552", "gene_names_uniprotkb": "ATM", "gene_names_refseq": "ATM", "protein_names_uniprotkb": "Serine-protein kinase ATM; 2.7.11.1; A-T mutated homolog; Ataxia telangiectasia mutated homolog", "protein_names_refseq": "A-T mutated homolog; ataxia telangiectasia mutated homolog; ataxia-telangiectasia mutated; serine-protein kinase ATM", "tax_id": 9823, "disease": "", "pathway": " (ssc:100101922)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16645841;17933474;25598069;26374845", "class_list": "", "function": "ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes., [RefSeq, PubMed]; ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules., [RefSeq, PubMed]; Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT, [RefSeq, PubMed]; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4, UCHL3 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (By similarity). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The extensive alternative splicing of the pATM gene resembles the complex splicing observed in the hATM and could provide insights for differences observed between mice and humans with regards to the onset of A-T, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix;GO:0005813 centrosome", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0010506 regulation of autophagy;GO:0043065 positive regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PQD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PQZ1-1", "uniprot_id": "AQP1_PIG", "mass": 28679.0, "length": 271, "protein_name": "Aquaporin-1", "gene_name": "AQP1", "organism": "Pig", "refseq_name": "aquaporin-1", "refseq_ac": "NP_999619", "gene_names_uniprotkb": "AQP1", "gene_names_refseq": "AQP1", "protein_names_uniprotkb": "Aquaporin-1; AQP-1; Aquaporin-CHIP", "protein_names_refseq": "AQP-1; aquaporin-1; aquaporin-CHIP; water channel protein for red blood cells and kidney proximal tubule", "tax_id": 9823, "disease": "", "pathway": " (ssc:407773)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16534851;18824632;20828411;26988150;27089501;27226190;29267208;29532265", "class_list": "", "function": "A functional and distinctive collaboration exists among diverse AQPs in water handling during the different uterine phases in the estrous cycle and early pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]; AQP1, AQP2, and AQP3, and V2R expression increased with gestation age in the fetal kidney, suggesting that this induction might contribute to the maturation of urinary concentrating capacity, [RefSeq, PubMed]; Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo., [UniProtKB, UniProtKB]; It seems possible that AQP1 present in granulosa and theca cells may be implicated not only in the regulation of water homeostasis required for follicle development but also in cell proliferation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; PAQP1 is the first porcine aquaporin that can be molecularly identified. Its distribution in epithelium and endothelium of digestive organs suggests a role of channel-mediated water transport in fluid secretion/absorption in the digestive function system., [RefSeq, PubMed]; Quantitative real-time PCR analysis showed markedly decreased mRNA levels of AQP1 and AQP5 and Na,K-ATPase in the Porcine reproductive and respiratory syndrome virus (PRRSV) -infected pig lungs compared to those of uninfected pig lungs., [RefSeq, PubMed]; Several subtypes of the AQPs (AQP1, 5, and 9) are involved in regulation of water homeostasis in the reproductive system of gilts., [RefSeq, PubMed]; These results suggest a participation of steroid hormones (P4 and E2), AA derivatives and cAMP in controlling the expression of AQP1 and AQP5 as well as the distribution of AQP5 in the uterine tissue of pregnant gilts during placentation (Days 30 - 32 of gestation)., [RefSeq, PubMed]; Up-regulated by progesterone, estradiol, arachidonic acid, forskolin, and cyclic AMP in the uterus during the embryo implantation period, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005267 potassium channel activity;GO:0005372 water transmembrane transporter activity;GO:0015168 glycerol transmembrane transporter activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0019725 cellular homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0071300 cellular response to retinoic acid;GO:0071320 cellular response to cAMP;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PQZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PQZ2-1", "uniprot_id": "CFTR_PIG", "mass": 168188.0, "length": 1482, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "CFTR", "organism": "Pig", "refseq_name": "cystic fibrosis transmembrane conductance regulator", "refseq_ac": "NP_001098420", "gene_names_uniprotkb": "CFTR; ABCC7", "gene_names_refseq": "ABCC7; CFTR", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; cAMP-dependent chloride channel", "protein_names_refseq": "ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator", "tax_id": 9823, "disease": "", "pathway": " (ssc:403154)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12917688;15001557;17112538;17873061;25136096;26286842;26823428;32130033;32719544;32730755", "class_list": "", "function": "Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus., [RefSeq, PubMed]; Analysis of species-dependent differences of CFTR-DeltaF508 in human, pig and mouse, [RefSeq, PubMed]; Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model., [RefSeq, PubMed]; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (By similarity). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (By similarity). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer (PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; In CFTR-knockout airways, the serous acini, collecting ducts, and ciliated ducts fail to transport ions after forskolin stimulation, resulting in the production of smaller volumes of ASL with normal Cl-, Na+, and K+ concentration., [RefSeq, PubMed]; Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands., [RefSeq, PubMed]; Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium., [RefSeq, PubMed]; Significant differences in CFTR channel mRNA and protein levels were present in atrial and ventricular cells, but not in regional ventricular cells across the ventricular wall from subepicardium to subendocardium, [RefSeq, PubMed]; The role of CFTR in submucosal gland fluid secretion was tested in pig airways. The reduced rate of gland fluid secretion after CFTR inhibition shown here provides strong evidence for the involvement of CFTR in glandular epithelial fluid transport., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2QLD5", "ec_number_list": "", "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0019869 chloride channel inhibitor activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0048240 sperm capacitation;GO:1902476 chloride transmembrane transport;GO:0060081 membrane hyperpolarization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PQZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Q2C2-1", "uniprot_id": "HYES_PIG", "mass": 62767.0, "length": 555, "protein_name": "Bifunctional epoxide hydrolase 2", "gene_name": "EPHX2", "organism": "Pig", "refseq_name": "bifunctional epoxide hydrolase 2", "refseq_ac": "NP_001001641", "gene_names_uniprotkb": "EPHX2", "gene_names_refseq": "EPHX2", "protein_names_uniprotkb": "Bifunctional epoxide hydrolase 2; Epoxide hydratase; SEH; Soluble epoxide hydrolase", "protein_names_refseq": "CEH; SEH; bifunctional epoxide hydrolase 2; cytosolic epoxide hydrolase; epoxide hydratase; soluble epoxide hydrolase", "tax_id": 9823, "disease": "", "pathway": " (ssc:414425); (R-SSC-2142670); (R-SSC-9018682); (R-SSC-9033241)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15308618", "class_list": "", "function": "Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:15308618). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004301 epoxide hydrolase activity;GO:0042577 lipid phosphatase activity;GO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0009636 response to toxic substance;GO:0046839 phospholipid dephosphorylation;GO:0097176 epoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Q2C2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Q2J0-1", "uniprot_id": "AOFA_PIG", "mass": 59763.0, "length": 527, "protein_name": "Amine oxidase [flavin-containing] A", "gene_name": "MAOA", "organism": "Pig", "refseq_name": "amine oxidase [flavin-containing] A", "refseq_ac": "NP_001001640", "gene_names_uniprotkb": "MAOA", "gene_names_refseq": "MAOA", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] A; 1.4.3.21; 1.4.3.4; MAO-A; Monoamine oxidase type A", "protein_names_refseq": "MAO-A; amine oxidase [flavin-containing] A; monoamine oxidase type A", "tax_id": 9823, "disease": "", "pathway": " (ssc:414424)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16147870", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline., [UniProtKB, UniProtKB]; Cloning and characterization of monoamine oxidase A and B genes in pig, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0006584 catecholamine metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Q2J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R2V0-1", "uniprot_id": "WNK1_PIG", "mass": 248976.0, "length": 2376, "protein_name": "Serine/threonine-protein kinase WNK1", "gene_name": "WNK1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WNK1; HSN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK1; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15060842", "class_list": "", "function": "Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx. WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation. The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK. Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity. Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux. Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation. Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (By similarity). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm. Acts as a negative regulator of autophagy. Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade. May also play a role in actin cytoskeletal reorganization (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1. Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "F1SHS6", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019902 phosphatase binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072686 mitotic spindle;GO:0043232 intracellular membraneless organelle", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045766 positive regulation of angiogenesis;GO:0006884 cell volume homeostasis;GO:0010507 negative regulation of autophagy;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6R2V0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RHW4-1", "uniprot_id": "HYAL1_PIG", "mass": 48507.0, "length": 435, "protein_name": "Hyaluronidase-1", "gene_name": "HYAL1", "organism": "Pig", "refseq_name": "hyaluronidase-1 isoform 2 precursor", "refseq_ac": "NP_999606", "gene_names_uniprotkb": "HYAL1", "gene_names_refseq": "HYAL1", "protein_names_uniprotkb": "Hyaluronidase-1; 3.2.1.35; Hyal-1; Hyaluronoglucosaminidase-1", "protein_names_refseq": "hyal-1; hyaluronidase-1 isoform 2 precursor; hyaluronoglucosaminidase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:404698)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15218248;19647381", "class_list": "", "function": "May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity)., [UniProtKB]; Results are consistent with a role for hyaluronan and hyaluronoglucosaminidase 1 and 2 in the development of the microscopic folds of the pig placenta during gestation, [RefSeq, PubMed]; The porcine hyaluronidase cluster consisting of genes HYAL1, HYAL2 and HYAL3 was characterized Erratum:[Cytogenet Genome Res. 2005;109(4):535], [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0036117 hyaluranon cable", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006954 inflammatory response;GO:0030307 positive regulation of cell growth;GO:0045785 positive regulation of cell adhesion;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6RHW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6RVA9-1", "uniprot_id": "CAV1_PIG", "mass": 20625.0, "length": 178, "protein_name": "Caveolin-1", "gene_name": "CAV1", "organism": "Pig", "refseq_name": "caveolin-1 isoform a", "refseq_ac": "NP_001335864", "gene_names_uniprotkb": "CAV1", "gene_names_refseq": "CAV1", "protein_names_uniprotkb": "Caveolin-1", "protein_names_refseq": "caveolin-1 isoform a", "tax_id": 9823, "disease": "", "pathway": " (ssc:404693)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12917688;19795378;21282513;21631282;25798057;33148167", "class_list": "", "function": "Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA IMFlnc1 promotes porcine intramuscular adipocyte adipogenesis by sponging miR-199a-5p to up-regulate CAV-1. Publication Status: Online-Only, [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF/TrkA signaling., [RefSeq, PubMed]; Transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1, [RefSeq, PubMed]; Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0PHA2;Q2QLE1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008142 oxysterol binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0031623 receptor internalization;GO:0031295 T cell costimulation;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6RVA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TA49-1", "uniprot_id": "IYD1_PIG", "mass": 33462.0, "length": 289, "protein_name": "Iodotyrosine deiodinase 1", "gene_name": "IYD", "organism": "Pig", "refseq_name": "iodotyrosine deiodinase 1", "refseq_ac": "NP_999581", "gene_names_uniprotkb": "IYD; DEHAL1", "gene_names_refseq": "DEHAL1; IYD", "protein_names_uniprotkb": "Iodotyrosine deiodinase 1; 1.21.1.1; IYD-1; Iodotyrosine dehalogenase 1", "protein_names_refseq": "IYD-1; iodotyrosine dehalogenase 1; iodotyrosine deiodinase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:403124)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15289438", "class_list": "", "function": "Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0140616 iodotyrosine deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0042403 thyroid hormone metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TA49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YT42-1", "uniprot_id": "Q6YT42_PIG", "mass": 42300.0, "length": 373, "protein_name": "C-C motif chemokine receptor 2", "gene_name": "CCR2", "organism": "Pig", "refseq_name": "C-C chemokine receptor type 2", "refseq_ac": "NP_001001619", "gene_names_uniprotkb": "CCR2", "gene_names_refseq": "CCR2", "protein_names_uniprotkb": "C-C motif chemokine receptor 2", "protein_names_refseq": "C-C chemokine receptor type 2; chemokine C-C motif receptor 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:414372); (R-SSC-1461957); (R-SSC-380108); (R-SSC-418594)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16926016;32543654", "class_list": "", "function": "Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCR2 by coronary artery transmural and perivascular cells in a sequential pattern, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0031727 CCR2 chemokine receptor binding;GO:0035717 chemokine (C-C motif) ligand 7 binding;GO:0035715 chemokine (C-C motif) ligand 2 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010820 positive regulation of T cell chemotaxis;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6YT42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70KH2-1", "uniprot_id": "GBA1_PIG", "mass": 59874.0, "length": 536, "protein_name": "Lysosomal acid glucosylceramidase", "gene_name": "GBA1", "organism": "Pig", "refseq_name": "lysosomal acid glucosylceramidase precursor", "refseq_ac": "NP_001005730", "gene_names_uniprotkb": "GBA1; GBA", "gene_names_refseq": "GBA1; GBA", "protein_names_uniprotkb": "Lysosomal acid glucosylceramidase; 2.4.1.-; 3.2.1.-; 3.2.1.45; 3.2.1.46; Acid beta-glucosidase; Beta-glucocerebrosidase; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; Lysosomal glycosylceramidase; SGTase", "protein_names_refseq": "D-glucosyl-N-acylsphingosine glucohydrolase; SGTase; acid beta-glucosidase; acid; beta-glucocerebrosidase; cholesterol glucosyltransferase; cholesteryl-beta-glucosidase; glucosidase, beta; lysosomal acid glucosylceramidase precursor; lysosomal acid glucosylceramidase; lysosomal cholesterol glycosyltransferase; lysosomal galactosylceramidase; lysosomal glucocerebrosidase; lysosomal glycosylceramidase; putative lysosomal glucocerebrosidase", "tax_id": 9823, "disease": "", "pathway": " (ssc:449572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15325338", "class_list": "", "function": "Genetic analysis and mapping of the porcine glucocerebrosidase (GBA) gene, [RefSeq, PubMed]; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0005102 signaling receptor binding;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0042391 regulation of membrane potential;GO:0016241 regulation of macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q70KH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q719N1-1", "uniprot_id": "SPAST_PIG", "mass": 67713.0, "length": 616, "protein_name": "Spastin", "gene_name": "SPAST", "organism": "Pig", "refseq_name": "spastin", "refseq_ac": "NP_998914", "gene_names_uniprotkb": "SPAST; SPG4", "gene_names_refseq": "SPAST; SPG4", "protein_names_uniprotkb": "Spastin; 5.6.1.1", "protein_names_refseq": "spastin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396584); (R-SSC-9668328)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17868079", "class_list": "", "function": "ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1S3Z2", "ec_number_list": "", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0051260 protein homooligomerization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q719N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q764M6-1", "uniprot_id": "IRF3_PIG", "mass": 46646.0, "length": 419, "protein_name": "Interferon regulatory factor 3", "gene_name": "IRF3", "organism": "Pig", "refseq_name": "interferon regulatory factor 3", "refseq_ac": "NP_998935", "gene_names_uniprotkb": "IRF3", "gene_names_refseq": "IRF3", "protein_names_uniprotkb": "Interferon regulatory factor 3; IRF-3", "protein_names_refseq": "IRF-3; interferon regulatory factor 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:396656); (R-SSC-1169408); (R-SSC-1606341); (R-SSC-168928); (R-SSC-3134973); (R-SSC-3134975); (R-SSC-3270619); (R-SSC-9013973); (R-SSC-918233); (R-SSC-933541); (R-SSC-936440); (R-SSC-936964)", "pathway_count": 12, "publication_count": 15, "publication_id_list": "14681463;17215286;20692306;25809915;27334592;31618847;33486326;34190598;34745071;35096660;35853521;35891444;36099692;37724880;38396775", "class_list": "", "function": "Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha/beta production., [RefSeq, PubMed]; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages., [UniProtKB, UniProtKB, PubMed]; PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production. Publication Status: Online-Only, [RefSeq, PubMed]; Proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro)., [RefSeq, PubMed]; The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3. Publication Status: Online-Only, [RefSeq, PubMed]; The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction., [RefSeq, PubMed]; The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex. Publication Status: Online-Only, [RefSeq, PubMed]; The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta promoter activity in MARC-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q764M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q764M9-1", "uniprot_id": "CXCR4_PIG", "mass": 39945.0, "length": 353, "protein_name": "C-X-C chemokine receptor type 4", "gene_name": "CXCR4", "organism": "Pig", "refseq_name": "C-X-C chemokine receptor type 4", "refseq_ac": "NP_998938", "gene_names_uniprotkb": "CXCR4", "gene_names_refseq": "CXCR4", "protein_names_uniprotkb": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4", "protein_names_refseq": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; chemokine (C-X-C motif) receptor 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:396659); (R-SSC-380108); (R-SSC-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14681463;16926016;22146760;22634721;29945222;31955063", "class_list": "", "function": "CXCR4 controls leukocyte mobilization after trauma. Publication Status: Online-Only, [RefSeq, PubMed]; Expression and function of the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in the swine ovarian follicle., [RefSeq, PubMed]; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Reports transmural and perivascular expression patterns of chemokines CCL2 and CXCL2 and of chemokine receptors CCR2, CCR5, and CXCR4 following coronary angioplasty, [RefSeq, PubMed]; The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration., [RefSeq, PubMed]; These results suggest that CXCL12 may be critical for the establishment of pregnancy by regulating trophoblast migration and T cell recruitment into the endometrium during the implantation period in pigs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031252 cell leading edge;GO:0005764 lysosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q764M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q767L7-1", "uniprot_id": "TBB5_PIG", "mass": 49671.0, "length": 444, "protein_name": "Tubulin beta chain", "gene_name": "TUBB", "organism": "Pig", "refseq_name": "tubulin beta chain", "refseq_ac": "NP_001038077", "gene_names_uniprotkb": "TUBB; TUBB5", "gene_names_refseq": "TUBB2A; TUBB", "protein_names_uniprotkb": "Tubulin beta chain; Tubulin beta-5 chain", "protein_names_refseq": "beta 5-tubulin; tubulin beta chain; tubulin beta-5 chain; tubulin, beta 2A class IIa", "tax_id": 9823, "disease": "", "pathway": " (ssc:733686); (R-SSC-2565942); (R-SSC-380259); (R-SSC-380270); (R-SSC-380284); (R-SSC-380320); (R-SSC-5620912); (R-SSC-6798695); (R-SSC-8854518)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "14673549;16441306;7225365", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:7225365). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:7225365). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:7225365)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q767L7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7YRZ1-1", "uniprot_id": "APTX_PIG", "mass": 40580.0, "length": 356, "protein_name": "Aprataxin", "gene_name": "APTX", "organism": "Pig", "refseq_name": "aprataxin isoform 1", "refseq_ac": "NP_998899", "gene_names_uniprotkb": "APTX", "gene_names_refseq": "APTX; FHA-HIT", "protein_names_uniprotkb": "Aprataxin; 3.6.1.71; 3.6.1.72; FHA-HIT; Forkhead-associated domain histidine triad-like protein", "protein_names_refseq": "aprataxin isoform 1; forkhead-associated domain histidine triad-like protein; forkhead-associated domain histidine-triad like", "tax_id": 9823, "disease": "", "pathway": " (ssc:387596)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding;GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0030983 mismatched DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7YRZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q863T6-1", "uniprot_id": "S22A1_PIG", "mass": 61226.0, "length": 554, "protein_name": "Solute carrier family 22 member 1", "gene_name": "SLC22A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC22A1; OCT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 22 member 1; Organic cation transporter 1; pOCT1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (By similarity). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation. Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline. Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover. Involved in the hepatic and intestinal uptake of the vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism. Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines across the basolateral membrane of hepatocytes, from the liver to the systemic circulation and inversely and may be involved in regulating the systemic availability of hepatic acylcarnitines (By similarity). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (By similarity). Also mediates the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0008504 monoamine transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015844 monoamine transport;GO:0015870 acetylcholine transport;GO:0015695 organic cation transport;GO:0006811 monoatomic ion transport;GO:0015872 dopamine transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q863T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q866Y3-1", "uniprot_id": "PGRP2_PIG", "mass": 64594.0, "length": 598, "protein_name": "N-acetylmuramoyl-L-alanine amidase", "gene_name": "PGLYRP2", "organism": "Pig", "refseq_name": "N-acetylmuramoyl-L-alanine amidase precursor", "refseq_ac": "NP_998903", "gene_names_uniprotkb": "PGLYRP2; PGRPL", "gene_names_refseq": "PGLYRP2; pPGRP-LB", "protein_names_uniprotkb": "N-acetylmuramoyl-L-alanine amidase; 3.5.1.28; PGRP-L; Peptidoglycan recognition protein 2; Peptidoglycan recognition protein long", "protein_names_refseq": "N-acetylmuramoyl-L-alanine amidase precursor; N-acetylmuramoyl-L-alanine amidase; PGRP-L; peptidoglycan recognition protein L; peptidoglycan recognition protein long", "tax_id": 9823, "disease": "", "pathway": " (ssc:396557)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16239507", "class_list": "", "function": "May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity., [UniProtKB]; Overexpression of pPGRP-L1 or pPGRP-L2 dramatically upregulates expression of beta-defensin-1, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q866Y4", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0016045 detection of bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q866Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q867B5-1", "uniprot_id": "RAG1_PIG", "mass": 119068.0, "length": 1043, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "RAG1", "organism": "Pig", "refseq_name": "V(D)J recombination-activating protein 1", "refseq_ac": "NP_001116656", "gene_names_uniprotkb": "RAG1", "gene_names_refseq": "RAG-1; RAG1", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; RAG-1; RING-type E3 ubiquitin transferase RAG1", "protein_names_refseq": "V(D)J recombination-activating protein 1; recombinase activating protein; recombination activating protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397506)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24973446;25437445", "class_list": "", "function": "Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity)., [UniProtKB]; Piglets with biallelic mutations in either RAG1 or RAG2 exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells., [RefSeq, PubMed]; Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID) phenotype similar to that of rodents and humans. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0030183 B cell differentiation;GO:0006325 chromatin organization;GO:0051865 protein autoubiquitination;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q867B5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8HYY9-1", "uniprot_id": "OSTCN_PIG", "mass": 5591.0, "length": 49, "protein_name": "Osteocalcin", "gene_name": "BGLAP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BGLAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "14586470;6332627", "class_list": "", "function": "The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:14586470). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0007611 learning or memory;GO:0032869 cellular response to insulin stimulus;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8HYY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8HZK2-1", "uniprot_id": "DUOX2_PIG", "mass": 175284.0, "length": 1545, "protein_name": "Dual oxidase 2", "gene_name": "DUOX2", "organism": "Pig", "refseq_name": "dual oxidase 2 precursor", "refseq_ac": "NP_999164", "gene_names_uniprotkb": "DUOX2", "gene_names_refseq": "DUOX2", "protein_names_uniprotkb": "Dual oxidase 2; 1.-.-.-; 1.11.1.-; 1.6.3.1; NADH/NADPH thyroid oxidase p138-tox", "protein_names_refseq": "NADH/NADPH thyroid oxidase p138-tox; dual oxidase 2 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397060)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10601291;12538618;12639906;15150274;15591162;15972824;28972010", "class_list": "", "function": "A novel recessive c.1226A>G transition of the dual oxidase 2 gene was identified as the causative mutation for a severe congenital hypothyroidism model together with anemia and T lymphopenia which mimics the clinical features of hypothyroid patients, [RefSeq, PubMed]; Expression along the length of the gastrointestinal tract., [RefSeq, PubMed]; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (PubMed:15972824). Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (By similarity). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (By similarity). May have its own peroxidase activity through its N-terminal peroxidase-like domain., [UniProtKB, PubMed, UniProtKB]; The dual oxidase 2 N-terminal region is targeted to the plasma membrane, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9TT98", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004601 peroxidase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0042335 cuticle development;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0042446 hormone biosynthetic process;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8HZK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8HZK3-1", "uniprot_id": "DUOX1_PIG", "mass": 177861.0, "length": 1553, "protein_name": "Dual oxidase 1", "gene_name": "DUOX1", "organism": "Pig", "refseq_name": "dual oxidase 1 precursor", "refseq_ac": "NP_999261", "gene_names_uniprotkb": "DUOX1", "gene_names_refseq": "DUOX1", "protein_names_uniprotkb": "Dual oxidase 1; 1.-.-.-; 1.11.1.-; 1.6.3.1", "protein_names_refseq": "dual oxidase 1 precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397177); (R-SSC-209968)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12639906;15591162", "class_list": "", "function": "Generates hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO (By similarity). Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa (By similarity). Antimicrobial agent hypothiocyanite (OSCN-), which is produced by LPO from DUOX1-derived H2O2, promotes influenza virus inactivation by reducing viral binding to and entry into host cells (By similarity). Promotes antiviral immunity by increasing airway cytokine levels, promoting innate immune cell recruitment and reducing airway epithelial cell apoptosis (By similarity). In response to bacterial stimuli, activated by ATP and promotes EGFR/ERK signaling, ADAM17 activation, and EGFR ligand shedding, leading to enhanced CXCL8/IL8 expression and secretion in airway epithelia (By similarity). Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation (By similarity). In addition to its oxidase activity, has also been shown to have peroxidase activity through its N-terminal peroxidase-like domain (By similarity). However, another study showed that the isolated peroxidase-like domain does not bind heme and has no intrinsic peroxidase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0071949 FAD binding;GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042335 cuticle development;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0042446 hormone biosynthetic process;GO:0032757 positive regulation of interleukin-8 production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8HZK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MIB3-1", "uniprot_id": "ABCG2_PIG", "mass": 72392.0, "length": 656, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2", "gene_name": "ABCG2", "organism": "Pig", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2", "refseq_ac": "NP_999175", "gene_names_uniprotkb": "ABCG2; BMDP", "gene_names_refseq": "ABCG2A; ABCG2; BMDP", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2; 7.6.2.2; ATP-binding cassette sub-family G member 2; Brain multidrug resistance protein; Urate exporter", "protein_names_refseq": "ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; brain multidrug resistance protein; broad substrate specificity ATP-binding cassette transporter ABCG2; urate exporter", "tax_id": 9823, "disease": "", "pathway": " (ssc:397073); (R-SSC-1660661); (R-SSC-189451); (R-SSC-189483); (R-SSC-917937); (R-SSC-9753281); (R-SSC-9793528)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "12054514;26661076", "class_list": "", "function": "Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:12054514). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015878 biotin transport;GO:0006869 lipid transport;GO:0055085 transmembrane transport;GO:0032218 riboflavin transport;GO:0097744 renal urate salt excretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8MIB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MJ14-1", "uniprot_id": "GPX1_PIG", "mass": 22591.0, "length": 206, "protein_name": "Glutathione peroxidase 1", "gene_name": "GPX1", "organism": "Pig", "refseq_name": "glutathione peroxidase 1", "refseq_ac": "NP_999366", "gene_names_uniprotkb": "GPX1", "gene_names_refseq": "GPX1", "protein_names_uniprotkb": "Glutathione peroxidase 1; 1.11.1.12; 1.11.1.9; Cellular glutathione peroxidase; GPx-1; GSHPx-1; Phospholipid-hydroperoxide glutathione peroxidase GPX1", "protein_names_refseq": "GPx-1; GSHPx-1; cellular glutathione peroxidase; cytosolic glutathione peroxidase; glutathione peroxidase 1; phospholipid-hydroperoxide glutathione peroxidase GPX1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397403)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16908641;22580339", "class_list": "", "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway., [UniProtKB, UniProtKB]; GPx1 plays a key role in blocking the promotion of porcine circovirus type 2 replication, [RefSeq, PubMed]; The developmental expression of GPX1 and thioredoxin reductase during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0034599 cellular response to oxidative stress;GO:0010269 response to selenium ion;GO:0042744 hydrogen peroxide catabolic process;GO:0019372 lipoxygenase pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8MJ14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MK48-1", "uniprot_id": "S22A6_PIG", "mass": 60063.0, "length": 547, "protein_name": "Solute carrier family 22 member 6", "gene_name": "SLC22A6", "organism": "Pig", "refseq_name": "solute carrier family 22 member 6", "refseq_ac": "NP_001001261", "gene_names_uniprotkb": "SLC22A6; OAT1", "gene_names_refseq": "OAT1; POAT1-1; SLC22A6", "protein_names_uniprotkb": "Solute carrier family 22 member 6; Organic anion transporter 1; ROAT1; Renal organic anion transporter 1; pOAT1", "protein_names_refseq": "ROAT1; organic anion transporter 1; organic anion transporter-like; pOAT1; putative organic anion transporter; renal organic anion transporter 1; solute carrier family 22 member 6", "tax_id": 9823, "disease": "", "pathway": " (ssc:397223)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12628298", "class_list": "", "function": "Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (By similarity). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8MK47", "ec_number_list": "", "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015711 organic anion transport;GO:0015742 alpha-ketoglutarate transport;GO:0097254 renal tubular secretion;GO:0015732 prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8MK48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SPP9-1", "uniprot_id": "TSHR_PIG", "mass": 86644.0, "length": 764, "protein_name": "Thyrotropin receptor", "gene_name": "TSHR", "organism": "Pig", "refseq_name": "thyrotropin receptor precursor", "refseq_ac": "NP_999462", "gene_names_uniprotkb": "TSHR", "gene_names_refseq": "TSHR", "protein_names_uniprotkb": "Thyrotropin receptor; TSH-R; Thyroid-stimulating hormone receptor", "protein_names_refseq": "TSH-R; Thyrotropin receptor; thyrotropin receptor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397560)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11847099;12880144", "class_list": "", "function": "Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (By similarity). Additionally, plays a central role in controlling thyroid cell metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9BG55;Q9BG56", "ec_number_list": "", "go_molecular_function": "GO:0004996 thyroid-stimulating hormone receptor activity;GO:0044877 protein-containing complex binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway;GO:0038194 thyroid-stimulating hormone signaling pathway;GO:1904588 cellular response to glycoprotein", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8SPP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SQC1-1", "uniprot_id": "SCRB1_PIG", "mass": 57514.0, "length": 509, "protein_name": "Scavenger receptor class B member 1", "gene_name": "SCARB1", "organism": "Pig", "refseq_name": "scavenger receptor class B member 1", "refseq_ac": "NP_999132", "gene_names_uniprotkb": "SCARB1", "gene_names_refseq": "SCARB1", "protein_names_uniprotkb": "Scavenger receptor class B member 1; High density lipoprotein receptor SR-BI; SR-BI; SRB1", "protein_names_refseq": "SRB1; high density lipoprotein receptor SR-BI; scavenger receptor class B member 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397018); (R-SSC-3000471); (R-SSC-8964011)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17698983", "class_list": "", "function": "Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes., [RefSeq, PubMed]; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0005044 scavenger receptor activity;GO:0008289 lipid binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0033344 cholesterol efflux;GO:0070508 cholesterol import;GO:0045056 transcytosis;GO:0034381 plasma lipoprotein particle clearance;GO:0043654 recognition of apoptotic cell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8SQC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8WN93-1", "uniprot_id": "CALRL_PIG", "mass": 53656.0, "length": 462, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "CALCRL", "organism": "Pig", "refseq_name": "calcitonin gene-related peptide type 1 receptor precursor", "refseq_ac": "NP_999260", "gene_names_uniprotkb": "CALCRL; CGRPR", "gene_names_refseq": "CALCRL; CGRPR; CRLR", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "CGRP type 1 receptor; Calcitonin gene-related peptide type 1 receptor; calcitonin gene-related peptide type 1 receptor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397172)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11714898;12630807;23966326", "class_list": "", "function": "Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide receptor; not adrenomedullin receptor). Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:11714898, PubMed:12630807). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:11714898, PubMed:12630807). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q867C1", "ec_number_list": "", "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1990410 adrenomedullin receptor signaling pathway;GO:1990408 calcitonin gene-related peptide receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8WN93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8WNR0-1", "uniprot_id": "COPT1_PIG", "mass": 20953.0, "length": 189, "protein_name": "High affinity copper uptake protein 1", "gene_name": "SLC31A1", "organism": "Pig", "refseq_name": "high affinity copper uptake protein 1", "refseq_ac": "NP_999265", "gene_names_uniprotkb": "SLC31A1; CTR1", "gene_names_refseq": "CTR1; SLC31A1", "protein_names_uniprotkb": "High affinity copper uptake protein 1; CTR1; Copper transporter 1; Solute carrier family 31 member 1", "protein_names_refseq": "copper transporter 1; high affinity copper uptake protein 1; high-affinity copper uptake protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:397186); (R-SSC-425410)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12580789;20699218", "class_list": "", "function": "Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells., [UniProtKB, UniProtKB]; Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (By similarity). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity. Also mediates the uptake of silver(1+). May function in the influx of the platinum-containing chemotherapeutic agents (By similarity). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). In vitro, mediates the transport of cadmium(2+) into cells. Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization. In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR. The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0005375 copper ion transmembrane transporter activity;GO:0015080 silver ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0035434 copper ion transmembrane transport;GO:0001525 angiogenesis;GO:0051259 protein complex oligomerization;GO:0006825 copper ion transport;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8WNR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8WNW2-1", "uniprot_id": "CCND2_PIG", "mass": 32643.0, "length": 288, "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "organism": "Pig", "refseq_name": "G1/S-specific cyclin-D2", "refseq_ac": "NP_999253", "gene_names_uniprotkb": "CCND2", "gene_names_refseq": "CCND2", "protein_names_uniprotkb": "G1/S-specific cyclin-D2", "protein_names_refseq": "G1/S-specific cyclin-D2", "tax_id": 9823, "disease": "", "pathway": " (ssc:397162); (R-SSC-69231); (R-SSC-8934593); (R-SSC-9754119)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "26359029", "class_list": "", "function": "Maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway, [RefSeq, PubMed]; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8WNW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8WP15-1", "uniprot_id": "GRK7_PIG", "mass": 62299.0, "length": 553, "protein_name": "Rhodopsin kinase GRK7", "gene_name": "GRK7", "organism": "Pig", "refseq_name": "rhodopsin kinase GRK7", "refseq_ac": "NP_999212", "gene_names_uniprotkb": "GRK7", "gene_names_refseq": "GPRK7; GRK7", "protein_names_uniprotkb": "Rhodopsin kinase GRK7; 2.7.11.14; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7", "protein_names_refseq": "g protein-coupled receptor kinase GRK7; rhodopsin kinase GRK7", "tax_id": 9823, "disease": "", "pathway": " (ssc:397114); (R-SSC-2514859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11717351;18803695", "class_list": "", "function": "Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8WP15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95247-1", "uniprot_id": "OPRM_PIG", "mass": 45099.0, "length": 401, "protein_name": "Mu-type opioid receptor", "gene_name": "OPRM1", "organism": "Pig", "refseq_name": "mu-type opioid receptor", "refseq_ac": "NP_001001538", "gene_names_uniprotkb": "OPRM1", "gene_names_refseq": "MOR; OPRM1", "protein_names_uniprotkb": "Mu-type opioid receptor; M-OR-1; MOR-1", "protein_names_refseq": "M-OR-1; MOR-1; mu opioid receptor; mu-type opioid receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396802)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9817447", "class_list": "", "function": "Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G protein complex and subsequent exchange of GDP for GTP in the G protein alpha subunit leading to dissociation of the G protein complex with the free GTP-bound G protein alpha and the G protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G protein-coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0005245 voltage-gated calcium channel activity;GO:0038047 morphine receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:2000310 regulation of NMDA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q95247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95254-1", "uniprot_id": "GHSR_PIG", "mass": 41195.0, "length": 366, "protein_name": "Growth hormone secretagogue receptor type 1", "gene_name": "GHSR", "organism": "Pig", "refseq_name": "growth hormone secretagogue receptor type 1", "refseq_ac": "NP_999345", "gene_names_uniprotkb": "GHSR", "gene_names_refseq": "GHSR", "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; GHRP; GHS-R; Ghrelin receptor", "protein_names_refseq": "GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor; growth hormone secretagogue receptor type 1b; growth hormone secretagogue receptor type 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397372); (R-SSC-416476)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18809347;33857472;8688086", "class_list": "", "function": "G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (By similarity). Upon activation, stimulates appetite and promotes growth hormone secretion (By similarity). Also binds other growth hormone releasing peptides (GHRP) as well as non-peptide, low molecular weight secretagogues (By similarity)., [UniProtKB, UniProtKB]; GHSR-1a is present in prepubertal pig ovary; no influence of GH on GHSR-1a expression is found., [RefSeq, PubMed]; Unusual orthologs shed new light on the binding mechanism of ghrelin to its receptor GHSR1a., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q95255", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001616 growth hormone secretagogue receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032691 negative regulation of interleukin-1 beta production;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q95254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95332-1", "uniprot_id": "BHMT1_PIG", "mass": 30134.0, "length": 278, "protein_name": "Betaine--homocysteine S-methyltransferase 1", "gene_name": "BHMT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BHMT", "gene_names_refseq": "", "protein_names_uniprotkb": "Betaine--homocysteine S-methyltransferase 1; 2.1.1.5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8798461;9281325", "class_list": "", "function": "Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0047150 betaine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0006579 amino-acid betaine catabolic process;GO:0071267 L-methionine salvage", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q95332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95334-1", "uniprot_id": "AMPE_PIG", "mass": 108284.0, "length": 942, "protein_name": "Glutamyl aminopeptidase", "gene_name": "ENPEP", "organism": "Pig", "refseq_name": "glutamyl aminopeptidase", "refseq_ac": "NP_999182", "gene_names_uniprotkb": "ENPEP", "gene_names_refseq": "ENPEP", "protein_names_uniprotkb": "Glutamyl aminopeptidase; 3.4.11.7; AP-A; Aminopeptidase A; EAP", "protein_names_refseq": "AP-A; EAP; aminopeptidase A; glutamyl aminopeptidase", "tax_id": 9823, "disease": "", "pathway": " (ssc:397080); (R-SSC-2022377)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9062131", "class_list": "", "function": "Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II., [UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004230 glutamyl aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0002003 angiotensin maturation;GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q95334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95JC9-1", "uniprot_id": "PRP_PIG", "mass": 62283.0, "length": 676, "protein_name": "Basic proline-rich protein", "gene_name": "", "organism": "Pig", "refseq_name": "basic proline-rich protein precursor", "refseq_ac": "NP_001092050", "gene_names_uniprotkb": "", "gene_names_refseq": "D2A; TP23", "protein_names_uniprotkb": "Basic proline-rich protein; PH-Ab", "protein_names_refseq": "basic proline-rich protein precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:100049648); (ssc:100113399)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15805110;16112392;7371600", "class_list": "", "function": "Cloning and functional study of porcine cDNAs that code for porcine parotid hormone and its complete amino acid sequence, [RefSeq, PubMed]; The parotid hormone stimulates dentinal fluid transport in teeth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84505;P84506;Q95JD0;Q95JD1", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q95JC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95L12-1", "uniprot_id": "FGF9_PIG", "mass": 23455.0, "length": 208, "protein_name": "Fibroblast growth factor 9", "gene_name": "FGF9", "organism": "Pig", "refseq_name": "fibroblast growth factor 9", "refseq_ac": "NP_998966", "gene_names_uniprotkb": "FGF9", "gene_names_refseq": "FGF9", "protein_names_uniprotkb": "Fibroblast growth factor 9; FGF-9; GAF; Glia-activating factor; HBGF-9", "protein_names_refseq": "FGF-9; GAF; HBGF-9; fibroblast growth factor 9; glia-activating factor", "tax_id": 9823, "disease": "", "pathway": " (ssc:396717); (R-SSC-109704); (R-SSC-1257604); (R-SSC-190322); (R-SSC-190373); (R-SSC-5654219); (R-SSC-5654228); (R-SSC-5654687); (R-SSC-5654688); (R-SSC-5654689); (R-SSC-5654693); (R-SSC-5654712); (R-SSC-5654719); (R-SSC-5654720); (R-SSC-5654726); (R-SSC-5654733); (R-SSC-5673001); (R-SSC-6811558)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "24664559;32049597", "class_list": "", "function": "Altrenogest affects expression of galectin-3 and fibroblast growth factor 9 in the reproductive tract of sows., [RefSeq, PubMed]; It was concluded that IGF-I-induced FGFR2IIIc mRNA may be a mechanism for increased responses to FGF9 in FSH plus IGF-I-treated granulosa cells., [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0008584 male gonad development;GO:0051781 positive regulation of cell division;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q95L12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95MQ5-1", "uniprot_id": "CD40L_PIG", "mass": 28869.0, "length": 261, "protein_name": "CD40 ligand", "gene_name": "CD40LG", "organism": "Pig", "refseq_name": "CD40 ligand", "refseq_ac": "NP_999291", "gene_names_uniprotkb": "CD40LG; CD40L; TNFSF5", "gene_names_refseq": "CD40LG; CD40L; TNFSF5", "protein_names_uniprotkb": "CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5", "protein_names_refseq": "CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome); CD40 ligand; CD40-L; tumor necrosis factor (ligand) superfamily, member 5", "tax_id": 9823, "disease": "", "pathway": " (ssc:397231)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18658029", "class_list": "", "function": "Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling., [UniProtKB, UniProtKB]; CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells, [RefSeq, PubMed]; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0005174 CD40 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0030168 platelet activation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q95MQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9BEA8-1", "uniprot_id": "TNFL6_PIG", "mass": 31756.0, "length": 282, "protein_name": "Tumor necrosis factor ligand superfamily member 6", "gene_name": "FASLG", "organism": "Pig", "refseq_name": "tumor necrosis factor ligand superfamily member 6", "refseq_ac": "NP_998971", "gene_names_uniprotkb": "FASLG; CD95L; FASL; TNFSF6", "gene_names_refseq": "CD95-L; FASLG; FASL; TNFSF6", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; Receptor-binding FasL ectodomain; SPA; SPPL2A-processed FasL form; Soluble Fas ligand; sFasL", "protein_names_refseq": "CD95 ligand; Fas ligand (TNF superfamily, member 6); fas antigen ligand; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6", "tax_id": 9823, "disease": "", "pathway": " (ssc:396726)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11429161;11792426;12371937;15303979;17321702;18503890;25177944", "class_list": "", "function": "Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:11429161, PubMed:12371937). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:11429161, PubMed:12371937). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Cytoplasmic form induces gene transcription inhibition., [UniProtKB, UniProtKB]; Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia. Publication Status: Online-Only, [RefSeq, PubMed]; FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta. Erratum:[Xenotransplantation. 2016 Mar;23(2):171-2. doi: 10.1111/xen.12200. PMID: 27106874], [RefSeq, PubMed]; Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process., [UniProtKB, UniProtKB]; The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported, [RefSeq, PubMed]; The result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q95M04;Q95N10", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0060205 cytoplasmic vesicle lumen;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006955 immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9BEA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GKY5-1", "uniprot_id": "GHRL_PIG", "mass": 12786.0, "length": 118, "protein_name": "Appetite-regulating hormone", "gene_name": "GHRL", "organism": "Pig", "refseq_name": "appetite-regulating hormone precursor", "refseq_ac": "NP_998972", "gene_names_uniprotkb": "GHRL", "gene_names_refseq": "GHRL; GRHL; ghrelin", "protein_names_uniprotkb": "Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide", "protein_names_refseq": "GH releasing peptide; appetite-regulating hormone precursor; appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; preproghrelin", "tax_id": 9823, "disease": "", "pathway": " (ssc:396728); (R-SSC-416476); (R-SSC-422085)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15536157;16793235;16920167;24534601;25294792;26388512;27264891;38828411", "class_list": "", "function": "Acyl modifications in bovine, porcine, and equine ghrelins. Publication Status: Online-Only, [RefSeq, PubMed]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Induces the release of growth hormone from the pituitary (By similarity). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, UniProtKB]; Ghrelin mRNA expression is up-regulated 10 days after weaning in the gastric fundus of piglets, coinciding with the increase of H(+)-K(+)-ATPase mRNA expression and activity, [RefSeq, PubMed]; Glucose output by primary porcine hepatocytes in suspension culture, after incubation with acylated ghrelin (AG), unacylated ghrelin (UAG), and hexarelin (HEX)., [RefSeq, PubMed]; Immunization against ghrelin was associated with increased antibody titers, decreased voluntary food consumption, and decreased body weight gain by pigs., [RefSeq, PubMed]; Obestatin enhances proliferation and differentiation of preadipocytes promoting PPARgamma and C/EBPa expression, and inhibiting preadipocyte apoptosis by decreasing expression of Caspase-3, Caspase-7 and Caspase-9., [RefSeq, PubMed]; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity)., [UniProtKB]; Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28., [UniProtKB, UniProtKB]; Slc30A8 colocalizes with ghrelin and motilin in the gastrointestinal tract of pigs, [RefSeq, PubMed]; Studied an alternative vascular approach to the modulation of gastric ghrelin levels.., [RefSeq, PubMed]; These expression data may indicate that factors other than ghrelin and leptin are more involved in the regulation of feed intake in pigs apparently acclimated to heat stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5X8W4;Q2I0G0;Q9BDG8;Q9GKY4", "ec_number_list": "", "go_molecular_function": "GO:0031768 ghrelin receptor binding;GO:0005179 hormone activity;GO:0030296 protein tyrosine kinase activator activity;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon", "go_biological_process": "GO:0032095 regulation of response to food;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016358 dendrite development;GO:0032024 positive regulation of insulin secretion;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9GKY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GKZ8-1", "uniprot_id": "Q9GKZ8_PIG", "mass": 21989.0, "length": 202, "protein_name": "Leukemia inhibitory factor", "gene_name": "LIF", "organism": "Pig", "refseq_name": "leukemia inhibitory factor precursor", "refseq_ac": "NP_999567", "gene_names_uniprotkb": "LIF", "gene_names_refseq": "LIF", "protein_names_uniprotkb": "Leukemia inhibitory factor", "protein_names_refseq": "leukemia inhibitory factor (cholinergic differentiation factor); leukemia inhibitory factor precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:399503); (R-SSC-6788467)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16160035;19002603;22339199;22920593;24307388;24621508;32543654", "class_list": "", "function": "Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos., [RefSeq, PubMed]; Favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene, [RefSeq, PubMed]; LIF and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation., [RefSeq, PubMed]; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes., [UniProtKB, UniProtKB]; Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway., [RefSeq, PubMed]; Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media., [RefSeq, PubMed]; The results indicated that the B allele at SNP locus LIF1 and the A allele at SNP locus LIF2 seem to have advantageous effects on litter size., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4X1VEA0", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0033630 positive regulation of cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9GKZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GL51-1", "uniprot_id": "LIS1_PIG", "mass": 46654.0, "length": 410, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha", "gene_name": "PAFAH1B1", "organism": "Pig", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha", "refseq_ac": "NP_999415", "gene_names_uniprotkb": "PAFAH1B1; LIS1; PAFAHA", "gene_names_refseq": "PAFAH1B1", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha; LIS-1; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha", "protein_names_refseq": "platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase Ib-alpha subunit", "tax_id": 9823, "disease": "", "pathway": " (ssc:397482)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005819 spindle;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0051301 cell division;GO:0016042 lipid catabolic process;GO:0007281 germ cell development;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9GL51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GL76-1", "uniprot_id": "NECT1_PIG", "mass": 57047.0, "length": 515, "protein_name": "Nectin-1", "gene_name": "NECTIN1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NECTIN1; HVEC; PRR1; PVRL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nectin-1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Nectin cell adhesion molecule 1; Poliovirus receptor-related protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:397247)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11277703;28542478", "class_list": "", "function": "(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001618 virus receptor activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0042734 presynaptic membrane;GO:0043296 apical junction complex", "go_biological_process": "GO:0046598 positive regulation of viral entry into host cell;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0090103 cochlea morphogenesis;GO:1902414 protein localization to cell junction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9GL76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLG4-1", "uniprot_id": "SCG1_PIG", "mass": 74392.0, "length": 668, "protein_name": "Secretogranin-1", "gene_name": "CHGB", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHGB", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretogranin-1; CgB; Chromogranin-B; Secretogranin I; SgI", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-381426); (R-SSC-8957275)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11168356", "class_list": "", "function": "Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9GLG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLN5-1", "uniprot_id": "BIRC5_PIG", "mass": 16298.0, "length": 142, "protein_name": "Baculoviral IAP repeat-containing protein 5", "gene_name": "BIRC5", "organism": "Pig", "refseq_name": "baculoviral IAP repeat-containing protein 5", "refseq_ac": "NP_999306", "gene_names_uniprotkb": "BIRC5", "gene_names_refseq": "BIRC5", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin", "protein_names_refseq": "apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; contains 1 BIR and 1 COOH-terminus coiled domain", "tax_id": 9823, "disease": "", "pathway": " (ssc:397266); (R-SSC-141430); (R-SSC-141444); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-4615885); (R-SSC-5663220); (R-SSC-68877); (R-SSC-8951664); (R-SSC-9648025)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "11435714;22506472;23388473", "class_list": "", "function": "Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression., [RefSeq, PubMed]; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity)., [UniProtKB, UniProtKB]; Report survivin expression in the normal pancreas., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0015631 tubulin binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0051233 spindle midzone;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9GLN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLP0-1", "uniprot_id": "ITB1_PIG", "mass": 88266.0, "length": 798, "protein_name": "Integrin beta-1", "gene_name": "ITGB1", "organism": "Pig", "refseq_name": "integrin beta-1 precursor", "refseq_ac": "NP_999133", "gene_names_uniprotkb": "ITGB1", "gene_names_refseq": "CD29; ITGB1", "protein_names_uniprotkb": "Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta", "protein_names_refseq": "VLA-4 subunit beta; fibronectin receptor subunit beta; integrin beta-1 precursor; integrin beta-1 subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)", "tax_id": 9823, "disease": "", "pathway": " (ssc:397019)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10972224;20453145;22237019;22805214", "class_list": "", "function": "Beta1-integrin antigen-antibody interactions and the distribution of beta1-integrin protein on spermatogonial stem cell membrane were demonstrated using atomic force microscopy, [RefSeq, PubMed]; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggested that the effect of G allele of integrin beta1 gene on litter size is significant in Large White and Landrace., [RefSeq, PubMed]; Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of {beta}1-integrin by IPEC-J2 cells., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0045202 synapse", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0031623 receptor internalization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9GLP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLP1-1", "uniprot_id": "FA5_PIG", "mass": 256080.0, "length": 2258, "protein_name": "Coagulation factor V", "gene_name": "F5", "organism": "Pig", "refseq_name": "coagulation factor V precursor", "refseq_ac": "NP_999285", "gene_names_uniprotkb": "F5", "gene_names_refseq": "F5", "protein_names_uniprotkb": "Coagulation factor V; Activated protein C cofactor", "protein_names_refseq": "activated protein C cofactor; coagulation factor V precursor", "tax_id": 9823, "disease": "", "pathway": " (ssc:397217)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11229814", "class_list": "", "function": "Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin., [UniProtKB]", "predicted_glycosites": 28, "predicted_n_glycosites": 28, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 28, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0007596 blood coagulation;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9GLP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLP2-1", "uniprot_id": "PROC_PIG", "mass": 51867.0, "length": 459, "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "organism": "Pig", "refseq_name": "vitamin K-dependent protein C precursor", "refseq_ac": "NP_999083", "gene_names_uniprotkb": "PROC", "gene_names_refseq": "PROC", "protein_names_uniprotkb": "Vitamin K-dependent protein C; 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV", "protein_names_refseq": "anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; vitamin K-dependent protein C precursor; vitamin K-dependent protein C", "tax_id": 9823, "disease": "", "pathway": " (ssc:396954)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11229814", "class_list": "", "function": "Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (By similarity). Exerts a protective effect on the endothelial cell barrier function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation;GO:0050728 negative regulation of inflammatory response;GO:1903142 positive regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9GLP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GLV6-1", "uniprot_id": "RIGI_PIG", "mass": 107584.0, "length": 940, "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "RIGI", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RIGI; DDX58", "gene_names_refseq": "", "protein_names_uniprotkb": "Antiviral innate immune response receptor RIG-I; 3.6.4.13; ATP-dependent RNA helicase DDX58; DEAD box protein 58; RHIV-1; RIG-1; RIG-I-like receptor 1; RIG-I; RLR-1; RNA helicase induced by virus; Retinoic acid-inducible gene 1 protein; Retinoic acid-inducible gene I protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10799277", "class_list": "", "function": "Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae, Rhabdoviridae: vesicular stomatitis virus (VSV) Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome. Detects dsRNA produced from non-self dsDNA by RNA polymerase III. May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0015629 actin cytoskeleton;GO:0032587 ruffle membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9GLV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9MZU4-1", "uniprot_id": "RSAD2_PIG", "mass": 41864.0, "length": 362, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "RSAD2", "organism": "Pig", "refseq_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "refseq_ac": "NP_998982", "gene_names_uniprotkb": "RSAD2; CIG6; IRG6", "gene_names_refseq": "CIG6; IRG6; RSAD2; SAND", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; 4.2.-.-; Inflammatory response gene 6 protein; Radical S-adenosyl methionine domain-containing protein 2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; inflammatory response gene 6 protein; inflammatory response protein 6; radical S-adenosyl methionine domain-containing protein 2; viperin; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "tax_id": 9823, "disease": "", "pathway": " (ssc:396752)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31517388;32719955;37703114;39334325", "class_list": "", "function": "Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (PubMed:31517388, PubMed:32719955). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; RSAD2 suppresses viral replication by interacting with the Senecavirus A 2 C protein. Publication Status: Online-Only, [RefSeq, PubMed]; The antiviral protein viperin interacts with the viral N protein to inhibit proliferation of porcine epidemic diarrhea virus., [RefSeq, PubMed]; The selected genes NR6A1, RSAD2-CMPK2, and COL3A1 contribute to body size variation in Meishan pigs through different patterns., [RefSeq, PubMed]; Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016829 lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0050709 negative regulation of protein secretion;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9MZU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N0X0-1", "uniprot_id": "AURKB_PIG", "mass": 39222.0, "length": 344, "protein_name": "Aurora kinase B", "gene_name": "AURKB", "organism": "Pig", "refseq_name": "aurora kinase B", "refseq_ac": "NP_999084", "gene_names_uniprotkb": "AURKB; AIK2; AIM1; AIRK2; ARK2; STK12; STK1; STK5", "gene_names_refseq": "AIM-1; ARK-2; AURKB; STK-1; STK12", "protein_names_uniprotkb": "Aurora kinase B; 2.7.11.1; AIM-1; ARK-2; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B", "protein_names_refseq": "Serine/threonine-protein kinase 12; aurora 1; aurora kinase B; aurora- and IPL1-like midbody-associated protein 1; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B", "tax_id": 9823, "disease": "", "pathway": " (ssc:396955)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12270407", "class_list": "", "function": "Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (By similarity). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YRC7", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0000776 kinetochore", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043687 post-translational protein modification;GO:0032466 negative regulation of cytokinesis;GO:0044878 mitotic cytokinesis checkpoint signaling;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9N0X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N1U3-1", "uniprot_id": "GCR_PIG", "mass": 85640.0, "length": 782, "protein_name": "Glucocorticoid receptor", "gene_name": "NR3C1", "organism": "Pig", "refseq_name": "glucocorticoid receptor", "refseq_ac": "NP_001008481", "gene_names_uniprotkb": "NR3C1; GRL", "gene_names_refseq": "GR; NO; NR3C1", "protein_names_uniprotkb": "Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1", "protein_names_refseq": "glucocorticoid receptor alpha; glucocorticoid receptor variant beta; glucocorticoid receptor variant gamma; glucocorticoid receptor; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)", "tax_id": 9823, "disease": "", "pathway": " (ssc:396740)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16271354;16421205;23950944;24503296;26066356;28360421", "class_list": "", "function": "Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1). Publication Status: Online-Only, [RefSeq, PubMed]; Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor)., [RefSeq, PubMed]; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression., [UniProtKB, UniProtKB, UniProtKB]; These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor binding to its promoter., [RefSeq, PubMed]; This study reveals the role of GR in muscle fiber inhibition on intramuscular adipocytes, and identifies myostatin as a muscle-derived modulator for adipose GR level. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P79405;Q5S4M0;Q9GKZ9", "ec_number_list": "", "go_molecular_function": "GO:0004883 nuclear glucocorticoid receptor activity;GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0071383 cellular response to steroid hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9N1U3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N2H9-1", "uniprot_id": "IL23A_PIG", "mass": 21132.0, "length": 193, "protein_name": "Interleukin-23 subunit alpha", "gene_name": "IL23A", "organism": "Pig", "refseq_name": "interleukin-23 subunit alpha precursor", "refseq_ac": "NP_001123708", "gene_names_uniprotkb": "IL23A; SGRF", "gene_names_refseq": "IL23A; SGRF; il23p19", "protein_names_uniprotkb": "Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; Interleukin-23 subunit p19", "protein_names_refseq": "IL-23 subunit alpha; IL-23-A; IL-23p19; interleukin 23, alpha subunit p19; interleukin-23 p19 subunit; interleukin-23 subunit alpha precursor; interleukin-23 subunit p19", "tax_id": 9823, "disease": "", "pathway": " (ssc:100155546); (R-SSC-9020933)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22032895", "class_list": "", "function": "Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells., [UniProtKB, UniProtKB]; These results provide genetic information about both swine IL-23 the IL-23 receptor alpha (IL-23Ralpha) and IL-12 receptor beta1 (IL-12Rbeta1), which allows for better understanding of interleukin systems involved in pig immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045519 interleukin-23 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070743 interleukin-23 complex", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0032693 negative regulation of interleukin-10 production;GO:0032740 positive regulation of interleukin-17 production;GO:0006954 inflammatory response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9N2H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N2I1-1", "uniprot_id": "CASP1_PIG", "mass": 44882.0, "length": 404, "protein_name": "Caspase-1", "gene_name": "CASP1", "organism": "Pig", "refseq_name": "caspase-1", "refseq_ac": "NP_999327", "gene_names_uniprotkb": "CASP1; IL1BC", "gene_names_refseq": "CASP1", "protein_names_uniprotkb": "Caspase-1; 3.4.22.36; CASP-1; ICE; IL-1 beta-converting enzyme; IL-1BC; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45", "protein_names_refseq": "CASP-1; ICE; IL-1 beta-converting enzyme; IL-1BC; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; p45", "tax_id": 9823, "disease": "", "pathway": " (ssc:397319)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10574622;20380728;25096901;26342830", "class_list": "", "function": "Endometrial expression of CASP1 and IL18 associated with pregnancy establishment; alteration of CASP1 and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy Publication Status: Online-Only, [RefSeq, PubMed]; Mmediately after hypoxia C8 and C1 follow a similar pattern of increase while long term this appears to dissociate, [RefSeq, PubMed]; Src kinase mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets, [RefSeq, PubMed]; Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097169 AIM2 inflammasome complex;GO:0072558 NLRP1 inflammasome complex;GO:0072559 NLRP3 inflammasome complex;GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9N2I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TSV5-1", "uniprot_id": "PO5F1_PIG", "mass": 38342.0, "length": 360, "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "POU5F1", "organism": "Pig", "refseq_name": "POU domain, class 5, transcription factor 1", "refseq_ac": "NP_001106531", "gene_names_uniprotkb": "POU5F1; OCT3; OCT4", "gene_names_refseq": "OCT3; OCT4; Oct-4; POU5F1", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 1; OTF-3; Oct-3; Oct-4; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3", "protein_names_refseq": "OTF-3; POU domain, class 5, transcription factor 1; oct-3; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100127461)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11169259;16460563;16541449;19738434;20663092;21089074;26708097;27067537;27210587;27996082;28139300", "class_list": "", "function": "Activin A and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 expression., [RefSeq, PubMed]; Cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level. Publication Status: Online-Only, [RefSeq, PubMed]; In the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively, [RefSeq, PubMed]; OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo., [RefSeq, PubMed]; Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells. Publication Status: Online-Only, [RefSeq, PubMed]; Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos., [RefSeq, PubMed]; Showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse, [RefSeq, PubMed]; Study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass, [RefSeq, PubMed]; These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding., [RefSeq, PubMed]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9TSV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TSX9-1", "uniprot_id": "PRDX6_PIG", "mass": 25037.0, "length": 224, "protein_name": "Peroxiredoxin-6", "gene_name": "PRDX6", "organism": "Pig", "refseq_name": "peroxiredoxin-6", "refseq_ac": "NP_999573", "gene_names_uniprotkb": "PRDX6", "gene_names_refseq": "1-Cys PRX; AOP2; LPCAT-5; PHGPX; PRDX6; aiPLA2", "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 3.1.1.4; Acidic calcium-independent phospholipase A2; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; aiPLA2", "protein_names_refseq": "1-Cys peroxiredoxin; LPC acyltransferase 5; NSGPx; acidic calcium-independent phospholipase A2; antioxidant protein 2; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; non-selenium glutathione phospholipid hydroperoxide peroxidase; peroxiredoxin-6", "tax_id": 9823, "disease": "", "pathway": " (ssc:399538); (R-SSC-3299685); (R-SSC-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22049688;26659441;33721217", "class_list": "", "function": "Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function. Erratum:[Virol Sin. 2021 Dec;36(6):1688-1689. doi: 10.1007/s12250-021-00466-9. PMID: 34766237], [RefSeq, PubMed]; The SNP of PRDX6 gene was significantly associated with the intramuscular fat and water moisture., [RefSeq, PubMed]; The expression of porcine Prdx6 gene is up-regulated by C/EBPbeta and CREB. Publication Status: Online-Only, [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006979 response to oxidative stress;GO:0046475 glycerophospholipid catabolic process;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9TSX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TTK7-1", "uniprot_id": "OLR1_PIG", "mass": 31143.0, "length": 274, "protein_name": "Oxidized low-density lipoprotein receptor 1", "gene_name": "OLR1", "organism": "Pig", "refseq_name": "oxidized low-density lipoprotein receptor 1", "refseq_ac": "NP_998970", "gene_names_uniprotkb": "OLR1; LOX1", "gene_names_refseq": "CLEC8A; LOX1; OLR-1; OLR1; PLOX-1", "protein_names_uniprotkb": "Oxidized low-density lipoprotein receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; Ox-LDL receptor 1", "protein_names_refseq": "C-type lectin domain family 8 member A; LOX-1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor-1; lectin-type oxidized LDL receptor 1; ox-LDL receptor 1; oxidized low-density lipoprotein receptor 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:396724); (R-SSC-202733); (R-SSC-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11284714", "class_list": "", "function": "Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0006954 inflammatory response;GO:0032930 positive regulation of superoxide anion generation;GO:0042157 lipoprotein metabolic process;GO:0007159 leukocyte cell-cell adhesion;GO:0042310 vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9TTK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TUI8-1", "uniprot_id": "FAAH1_PIG", "mass": 62857.0, "length": 579, "protein_name": "Fatty-acid amide hydrolase 1", "gene_name": "FAAH", "organism": "Pig", "refseq_name": "fatty-acid amide hydrolase 1", "refseq_ac": "NP_999079", "gene_names_uniprotkb": "FAAH; FAAH1", "gene_names_refseq": "FAAH1; FAAH", "protein_names_uniprotkb": "Fatty-acid amide hydrolase 1; 3.1.1.-; 3.5.1.99; Anandamide amidase; Anandamide amidohydrolase 1; Fatty acid ester hydrolase; Oleamide hydrolase 1", "protein_names_refseq": "anandamide amidase; anandamide amidohydrolase 1; fatty acid ester hydrolase; fatty-acid amide hydrolase 1; oleamide hydrolase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:396949); (R-SSC-2142753)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10526230;12664593;32599254", "class_list": "", "function": "Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:10526230, PubMed:12664593). Also catalyzes the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:12664593). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Immunolocalization of cannabinoid receptor 1 (CB1), monoglyceride lipase (MGL) and fatty-acid amide hydrolase 1 (FAAH) in the pig claustrum., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004040 amidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0052651 monoacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9TUI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TUZ0-1", "uniprot_id": "STA5B_PIG", "mass": 89902.0, "length": 787, "protein_name": "Signal transducer and activator of transcription 5B", "gene_name": "STAT5B", "organism": "Pig", "refseq_name": "signal transducer and activator of transcription 5B", "refseq_ac": "NP_999333", "gene_names_uniprotkb": "STAT5B", "gene_names_refseq": "STAT5B", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5B", "protein_names_refseq": "signal transducer and activator of transcription 5B", "tax_id": 9823, "disease": "", "pathway": " (ssc:397340)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16882096", "class_list": "", "function": "A study of the polymorphisms of STAT5b is presented, and the use of radiation hybrid mapping to localize the gene to chromosome 12 is presented., [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0046543 development of secondary female sexual characteristics;GO:0046544 development of secondary male sexual characteristics;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9TUZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TUZ1-1", "uniprot_id": "STA5A_PIG", "mass": 90954.0, "length": 799, "protein_name": "Signal transducer and activator of transcription 5A", "gene_name": "STAT5A", "organism": "Pig", "refseq_name": "signal transducer and activator of transcription 5A", "refseq_ac": "NP_999455", "gene_names_uniprotkb": "STAT5A", "gene_names_refseq": "STAT5A", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5A", "protein_names_refseq": "signal transducer and activator of transcription 5A", "tax_id": 9823, "disease": "", "pathway": " (ssc:397550)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16484801", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity)., [UniProtKB]; Mapped to chromosome 12 by radiation hybrid mapping., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0046543 development of secondary female sexual characteristics;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9TUZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XT00-1", "uniprot_id": "DHB8_PIG", "mass": 26622.0, "length": 259, "protein_name": "(3R)-3-hydroxyacyl-CoA dehydrogenase", "gene_name": "HSD17B8", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSD17B8; FABGL; HKE6", "gene_names_refseq": "", "protein_names_uniprotkb": "(3R)-3-hydroxyacyl-CoA dehydrogenase; 1.1.1.239; 1.1.1.62; 1.1.1.n12; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; Estradiol 17-beta-dehydrogenase 8; KAR alpha subunit; Ke-6; Protein Ke6; Testosterone 17-beta-dehydrogenase 8", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12030927", "class_list": "", "function": "Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048038 quinone binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0070404 NADH binding;GO:0106386 (3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XT00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XT90-1", "uniprot_id": "MMP14_PIG", "mass": 65934.0, "length": 580, "protein_name": "Matrix metalloproteinase-14", "gene_name": "MMP14", "organism": "Pig", "refseq_name": "matrix metalloproteinase-14 precursor", "refseq_ac": "NP_999404", "gene_names_uniprotkb": "MMP14", "gene_names_refseq": "MMP14; MT1-MMP", "protein_names_uniprotkb": "Matrix metalloproteinase-14; 3.4.24.80; MMP-14; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "MMP-14; MT-MMP 1; MT1MMP; MTMMP1; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase-14 precursor; matrix metalloproteinase-14; membrane-type 1 matrix metalloproteinase; membrane-type matrix metalloproteinase 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397471)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15297252;15528467;15723986;20935147;23102905;9881602", "class_list": "", "function": "A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling., [RefSeq, PubMed]; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis., [UniProtKB, UniProtKB, UniProtKB]; In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion., [RefSeq, PubMed]; Induction of endogenous MMP-14 gene and coexpression of SAF-1 & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 as a key regulator of MMP-14 gene induction in macrophage cells., [RefSeq, PubMed]; Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion., [RefSeq, PubMed]; PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0042470 melanosome", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0016477 cell migration;GO:0030198 extracellular matrix organization;GO:0030324 lung development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9XT90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2Q8U4-1", "uniprot_id": "A0A5G2Q8U4_PIG", "mass": 47347.0, "length": 421, "protein_name": "Cysteine protease", "gene_name": "ATG4B", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATG4B", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine protease; 3.4.22.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1632852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0097110 scaffold protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0006508 proteolysis;GO:0015031 protein transport;GO:0006914 autophagy;GO:0000045 autophagosome assembly;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q8U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VPT2-1", "uniprot_id": "A0A4X1VPT2_PIG", "mass": 29115.0, "length": 271, "protein_name": "Elastase, neutrophil expressed", "gene_name": "ELANE", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ELANE", "gene_names_refseq": "", "protein_names_uniprotkb": "Elastase, neutrophil expressed", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1474228); (R-SSC-1592389); (R-SSC-5620971); (R-SSC-6798695); (R-SSC-6803157); (R-SSC-977606)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I3LK80", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0002020 protease binding;GO:0008201 heparin binding;GO:0003714 transcription corepressor activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0009986 cell surface;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006508 proteolysis;GO:0002812 biosynthetic process of antibacterial peptides active against Gram-negative bacteria;GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0070947 neutrophil-mediated killing of fungus;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VPT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VWK0-1", "uniprot_id": "A0A4X1VWK0_PIG", "mass": 48991.0, "length": 435, "protein_name": "Serine/threonine-protein kinase 40", "gene_name": "STK40", "organism": "Pig", "refseq_name": "serine/threonine-protein kinase 40 isoform X1", "refseq_ac": "XP_020951598", "gene_names_uniprotkb": "STK40", "gene_names_refseq": "STK40", "protein_names_uniprotkb": "Serine/threonine-protein kinase 40; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 40 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100625215)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May be a negative regulator of NF-kappa-B and p53-mediated gene transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480PW25", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VWK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VG91-1", "uniprot_id": "A0A4X1VG91_PIG", "mass": 147213.0, "length": 1288, "protein_name": "Structural maintenance of chromosomes protein", "gene_name": "SMC4", "organism": "Pig", "refseq_name": "structural maintenance of chromosomes protein 4 isoform X2", "refseq_ac": "XP_005670009", "gene_names_uniprotkb": "SMC4", "gene_names_refseq": "SMC4", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein", "protein_names_refseq": "structural maintenance of chromosomes protein 4 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152361); (R-SSC-2299718); (R-SSC-2514853)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZZ63;A0A480E9Z3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0000796 condensin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0051301 cell division;GO:0030261 chromosome condensation;GO:0098813 nuclear chromosome segregation;GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VG91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QD41-1", "uniprot_id": "A0A5G2QD41_PIG", "mass": 46688.0, "length": 419, "protein_name": "Voltage-gated potassium channel subunit beta-1", "gene_name": "KCNAB1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KCNAB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1296072)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0019904 protein domain specific binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005829 cytosol;GO:0008076 voltage-gated potassium channel complex;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006813 potassium ion transport;GO:1901379 regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QD41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1WBI1-1", "uniprot_id": "A0A4X1WBI1_PIG", "mass": 54427.0, "length": 489, "protein_name": "Keratin, type II cytoskeletal 8", "gene_name": "KRT8", "organism": "Pig", "refseq_name": "keratin, type II cytoskeletal 8", "refseq_ac": "NP_001153087", "gene_names_uniprotkb": "KRT8", "gene_names_refseq": "KRT8", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 8; Cytokeratin-8; Keratin-8; Type-II keratin Kb8", "protein_names_refseq": "keratin, type II cytoskeletal 8", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152077); (R-SSC-6805567); (R-SSC-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18432282;23196707;32543654", "class_list": "", "function": "Mechanical injury of vascular smooth muscle up-regulated keratin 8., [RefSeq, PubMed]; Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 and PTH1R with some of leg weakness related traits in pigs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287ARG4", "ec_number_list": "", "go_molecular_function": "GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0045095 keratin filament;GO:0005911 cell-cell junction", "go_biological_process": "GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A4X1WBI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V2B9-1", "uniprot_id": "A0A4X1V2B9_PIG", "mass": 36842.0, "length": 314, "protein_name": "Elongation of very long chain fatty acids protein 4", "gene_name": "ELOVL4", "organism": "Pig", "refseq_name": "elongation of very long chain fatty acids protein 4 isoform X2", "refseq_ac": "XP_020947766", "gene_names_uniprotkb": "ELOVL4", "gene_names_refseq": "ELOVL4", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 4; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL4; ELOVL FA elongase 4; ELOVL fatty acid elongase 4; Very long chain 3-ketoacyl-CoA synthase 4; Very long chain 3-oxoacyl-CoA synthase 4", "protein_names_refseq": "elongation of very long chain fatty acids protein 4 isoform X2", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I3LVJ0", "ec_number_list": "", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V2B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V9F0-1", "uniprot_id": "A0A4X1V9F0_PIG", "mass": 53723.0, "length": 464, "protein_name": "Glycine receptor alpha 3", "gene_name": "GLRA3", "organism": "Pig", "refseq_name": "glycine receptor subunit alpha-3 isoform X6", "refseq_ac": "XP_020929846", "gene_names_uniprotkb": "GLRA3", "gene_names_refseq": "GLRA3", "protein_names_uniprotkb": "Glycine receptor alpha 3", "protein_names_refseq": "glycine receptor subunit alpha-3 isoform X6", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515280); (R-SSC-112314)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZTQ5;F1RJ16", "ec_number_list": "", "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0016594 glycine binding;GO:0022852 glycine-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection;GO:0016935 glycine-gated chloride channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V9F0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QD15-1", "uniprot_id": "A0A5G2QD15_PIG", "mass": 55309.0, "length": 497, "protein_name": "GMP reductase", "gene_name": "GMPR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GMPR", "gene_names_refseq": "", "protein_names_uniprotkb": "GMP reductase; 1.7.1.7; GMPR; Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-74217)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003920 GMP reductase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:1902560 GMP reductase complex", "go_biological_process": "GO:0006144 purine nucleobase metabolic process;GO:0006163 purine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QD15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VNG8-1", "uniprot_id": "A0A4X1VNG8_PIG", "mass": 27408.0, "length": 242, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "NAA60", "organism": "Pig", "refseq_name": "N-alpha-acetyltransferase 60 isoform X1", "refseq_ac": "XP_020943772", "gene_names_uniprotkb": "NAA60", "gene_names_refseq": "NAA60", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F", "protein_names_refseq": "N-alpha-acetyltransferase 60 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100739355)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5K1U7N7;I3L5W7;K9J4R4", "ec_number_list": "", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity;GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0006325 chromatin organization;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VNG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VQ10-1", "uniprot_id": "A0A4X1VQ10_PIG", "mass": 110783.0, "length": 974, "protein_name": "BICD cargo adaptor 1", "gene_name": "BICD1", "organism": "Pig", "refseq_name": "protein bicaudal D homolog 1 isoform X3", "refseq_ac": "XP_003126445", "gene_names_uniprotkb": "BICD1", "gene_names_refseq": "BICD1", "protein_names_uniprotkb": "BICD cargo adaptor 1", "protein_names_refseq": "protein bicaudal D homolog 1 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100511132)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QFK4", "ec_number_list": "", "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0070840 dynein complex binding;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1904781 positive regulation of protein localization to centrosome;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0019068 virion assembly;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0072385 minus-end-directed organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VQ10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W928-1", "uniprot_id": "A0A4X1W928_PIG", "mass": 60039.0, "length": 548, "protein_name": "T-complex protein 1 subunit eta", "gene_name": "CCT7", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CCT7", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 1 subunit eta; CCT-eta; TCP-1-eta", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-390471); (R-SSC-6814122); (R-SSC-9013418); (R-SSC-9013422)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2RAV7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005832 chaperonin-containing T-complex;GO:0005874 microtubule;GO:0044297 cell body", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VIC7-1", "uniprot_id": "A0A4X1VIC7_PIG", "mass": 33556.0, "length": 302, "protein_name": "Syntaxin-17", "gene_name": "STX17", "organism": "Pig", "refseq_name": "syntaxin-17 isoform X1", "refseq_ac": "XP_005660334", "gene_names_uniprotkb": "STX17", "gene_names_refseq": "STX17", "protein_names_uniprotkb": "Syntaxin-17", "protein_names_refseq": "syntaxin-17 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157063); (R-SSC-204005)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A481CAI8", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0000149 SNARE binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VIC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2Q9C7-1", "uniprot_id": "A0A5G2Q9C7_PIG", "mass": 56551.0, "length": 507, "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "CCT3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CCT3", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 1 subunit gamma", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-390471); (R-SSC-6814122)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005832 chaperonin-containing T-complex;GO:0005874 microtubule;GO:0044297 cell body;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q9C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2Q7L9-1", "uniprot_id": "A0A5G2Q7L9_PIG", "mass": 42438.0, "length": 379, "protein_name": "Presenilin-associated rhomboid-like protein, mitochondrial", "gene_name": "PARL", "organism": "Pig", "refseq_name": "presenilins-associated rhomboid-like protein, mitochondrial isoform X1", "refseq_ac": "XP_003483328", "gene_names_uniprotkb": "PARL", "gene_names_refseq": "PARL", "protein_names_uniprotkb": "Presenilin-associated rhomboid-like protein, mitochondrial; 3.4.21.105", "protein_names_refseq": "presenilins-associated rhomboid-like protein, mitochondrial isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100739380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing;GO:0030162 regulation of proteolysis;GO:2000377 regulation of reactive oxygen species metabolic process;GO:0008053 mitochondrial fusion;GO:0090201 negative regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q7L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VW00-1", "uniprot_id": "A0A4X1VW00_PIG", "mass": 15177.0, "length": 133, "protein_name": "U6 snRNA-associated Sm-like protein LSm1", "gene_name": "LSM1; 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Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8W4FEJ4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:1990904 ribonucleoprotein complex;GO:1990726 Lsm1-7-Pat1 complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0071044 histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VW00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1WBE0-1", "uniprot_id": "A0A4X1WBE0_PIG", "mass": 123114.0, "length": 1071, "protein_name": "Exportin-1", "gene_name": "XPO1", "organism": "Pig", "refseq_name": "exportin-1 isoform X1", "refseq_ac": "XP_020943143", "gene_names_uniprotkb": "XPO1", "gene_names_refseq": "XPO1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance 1 protein homolog", "protein_names_refseq": "exportin-1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-141430); (R-SSC-141444); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-450520); (R-SSC-5663220); (R-SSC-5687128); (R-SSC-68877); (R-SSC-69273); (R-SSC-9634638); (R-SSC-9648025); (R-SSC-9707616); (R-SSC-9856649)", "pathway_count": 13, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZTK1", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006611 protein export from nucleus;GO:0051028 mRNA transport;GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1WBE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1WCI1-1", "uniprot_id": "A0A4X1WCI1_PIG", "mass": 69490.0, "length": 600, "protein_name": "Intraflagellar transport 74", "gene_name": "IFT74", "organism": "Pig", "refseq_name": "intraflagellar transport protein 74 homolog isoform X1", "refseq_ac": "XP_001926178", "gene_names_uniprotkb": "IFT74", "gene_names_refseq": "IFT74", "protein_names_uniprotkb": "Intraflagellar transport 74", "protein_names_refseq": "intraflagellar transport protein 74 homolog isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157070); 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Sodium borate cotransporter 1", "protein_names_refseq": "sodium bicarbonate transporter-like protein 11 isoform X8", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0022857 transmembrane transporter activity;GO:0046983 protein dimerization activity;GO:0005372 water transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006820 monoatomic anion transport;GO:0050801 monoatomic ion homeostasis;GO:0042044 fluid transport;GO:0071476 cellular hypotonic response;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QDU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QEZ9-1", "uniprot_id": "A0A5G2QEZ9_PIG", "mass": 64949.0, "length": 567, "protein_name": "Phosphodiesterase", "gene_name": "PDE1A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PDE1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-111957); (R-SSC-418457); (R-SSC-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity;GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QEZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UYT9-1", "uniprot_id": "A0A4X1UYT9_PIG", "mass": 9767.0, "length": 82, "protein_name": "Cytochrome b-c1 complex subunit 8", "gene_name": "UQCRQ", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UQCRQ", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 8; Complex III subunit 8", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100524308); (R-SSC-611105); (R-SSC-9837999); (R-SSC-9865881)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "27912063;32543654", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RI18", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0021766 hippocampus development;GO:0021680 cerebellar Purkinje cell layer development;GO:0021860 pyramidal neuron development;GO:0021854 hypothalamus development;GO:0021539 subthalamus development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A4X1UYT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1UZN2-1", "uniprot_id": "A0A4X1UZN2_PIG", "mass": 13724.0, "length": 118, "protein_name": "V-type proton ATPase subunit G", "gene_name": "ATP6V1G1", "organism": "Pig", "refseq_name": "V-type proton ATPase subunit G 1", "refseq_ac": "NP_001177123", "gene_names_uniprotkb": "ATP6V1G1", "gene_names_refseq": "ATP6V1G1", "protein_names_uniprotkb": "V-type proton ATPase subunit G", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1; V-type proton ATPase subunit G 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154379); (R-SSC-1222556); (R-SSC-77387); (R-SSC-917977); (R-SSC-9639288); (R-SSC-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "32543654;35794005", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AKZ9", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030672 synaptic vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A4X1UZN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V067-1", "uniprot_id": "A0A4X1V067_PIG", "mass": 42481.0, "length": 377, "protein_name": "Nucleoside diphosphate kinase 7", "gene_name": "NME7", "organism": "Pig", "refseq_name": "nucleoside diphosphate kinase 7 isoform X2", "refseq_ac": "XP_020945099", "gene_names_uniprotkb": "NME7", "gene_names_refseq": "NME7", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 7; NDK7", "protein_names_refseq": "nucleoside diphosphate kinase 7 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-380270); (R-SSC-380320)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly and ciliary microtubule stability. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RPV8", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0008408 3'-5' exonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0006308 DNA catabolic process;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V1H8-1", "uniprot_id": "A0A4X1V1H8_PIG", "mass": 96959.0, "length": 847, "protein_name": "Phospholipase A2", "gene_name": "PLA2G4E", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PLA2G4E", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1482788); (R-SSC-1482801); (R-SSC-1482839); (R-SSC-1482922); (R-SSC-1483115)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287BBG6", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:2001137 positive regulation of endocytic recycling;GO:0019370 leukotriene biosynthetic process;GO:0006071 glycerol metabolic process;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V1H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V2Q7-1", "uniprot_id": "A0A4X1V2Q7_PIG", "mass": 100259.0, "length": 890, "protein_name": "Kinesin-like protein", "gene_name": "KIF20A", "organism": "Pig", "refseq_name": "kinesin-like protein KIF20A isoform X2", "refseq_ac": "XP_003124000", "gene_names_uniprotkb": "KIF20A", "gene_names_refseq": "KIF20A", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF20A isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515193); (R-SSC-2132295); (R-SSC-6811434); (R-SSC-68884); (R-SSC-983189)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480JET8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement;GO:0032465 regulation of cytokinesis;GO:0001578 microtubule bundle formation;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V2Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V321-1", "uniprot_id": "A0A4X1V321_PIG", "mass": 121348.0, "length": 1091, "protein_name": "Cytospin-A", "gene_name": "SPECC1L", "organism": "Pig", "refseq_name": "cytospin-A isoform X3", "refseq_ac": "XP_020929461", "gene_names_uniprotkb": "SPECC1L", "gene_names_refseq": "SPECC1L", "protein_names_uniprotkb": "Cytospin-A", "protein_names_refseq": "cytospin-A isoform X3", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1RLS1", "ec_number_list": "", "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005815 microtubule organizing center;GO:0031941 filamentous actin;GO:0005921 gap junction", "go_biological_process": "GO:0051301 cell division;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1V6Z6-1", "uniprot_id": "A0A4X1V6Z6_PIG", "mass": 40744.0, "length": 361, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "ATAD1", "organism": "Pig", "refseq_name": "ATPase family AAA domain-containing protein 1 isoform X1", "refseq_ac": "XP_001928012", "gene_names_uniprotkb": "ATAD1", "gene_names_refseq": "ATAD1", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; ATPase family AAA domain-containing protein 1; Thorase", "protein_names_refseq": "ATPase family AAA domain-containing protein 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157471); (R-SSC-9603798)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane. Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z5H2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0002092 positive regulation of receptor internalization;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1V6Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VAU7-1", "uniprot_id": "A0A4X1VAU7_PIG", "mass": 38502.0, "length": 350, "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "STRAP", "organism": "Pig", "refseq_name": "serine-threonine kinase receptor-associated protein", "refseq_ac": "XP_003355612", "gene_names_uniprotkb": "STRAP", "gene_names_refseq": "STRAP", "protein_names_uniprotkb": "Serine-threonine kinase receptor-associated protein", "protein_names_refseq": "serine-threonine kinase receptor-associated protein", "tax_id": 9823, "disease": "", "pathway": " (ssc:100624126); (R-SSC-2173788)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480YLE4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:0016301 kinase activity;GO:1990447 U2 snRNP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032797 SMN complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000387 spliceosomal snRNP assembly;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VAU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VCL1-1", "uniprot_id": "A0A4X1VCL1_PIG", "mass": 48634.0, "length": 433, "protein_name": "26S proteasome regulatory subunit 7", "gene_name": "PSMC2", "organism": "Pig", "refseq_name": "26S proteasome regulatory subunit 7", "refseq_ac": "NP_001231937", "gene_names_uniprotkb": "PSMC2", "gene_names_refseq": "PSMC2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2", "protein_names_refseq": "26S proteasome regulatory subunit 7; proteasome (prosome, macropain) 26S subunit, ATPase, 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100514865); (R-SSC-1169091); (R-SSC-1234176); (R-SSC-1236978); (R-SSC-174084); (R-SSC-174154); (R-SSC-174178); (R-SSC-174184); (R-SSC-187577); (R-SSC-202424); (R-SSC-2467813); (R-SSC-2871837); (R-SSC-349425); (R-SSC-350562); (R-SSC-382556); (R-SSC-450408); (R-SSC-4608870); (R-SSC-4641257); (R-SSC-4641258); (R-SSC-5358346); (R-SSC-5607761); (R-SSC-5607764); (R-SSC-5610780); (R-SSC-5610785); (R-SSC-5632684); (R-SSC-5658442); (R-SSC-5668541); (R-SSC-5676590); (R-SSC-5687128); (R-SSC-5689603); (R-SSC-5689880); (R-SSC-6798695); (R-SSC-68867); (R-SSC-68949); (R-SSC-69017); (R-SSC-69481); (R-SSC-69601); (R-SSC-75815); (R-SSC-8852276); (R-SSC-8854050); (R-SSC-8939236); (R-SSC-8939902); (R-SSC-8941858); (R-SSC-8948751); (R-SSC-8951664); (R-SSC-9020702); (R-SSC-9755511); (R-SSC-9766229); (R-SSC-983168); (R-SSC-9907900); (R-SSC-9931269); (R-SSC-9932298); (R-SSC-9954709)", "pathway_count": 53, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SB53", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005829 cytosol;GO:0000932 P-body;GO:0005737 cytoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VCL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VDA7-1", "uniprot_id": "A0A4X1VDA7_PIG", "mass": 50653.0, "length": 445, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "SGK1", "organism": "Pig", "refseq_name": "serine/threonine-protein kinase Sgk1 isoform X3", "refseq_ac": "XP_020934240", "gene_names_uniprotkb": "SGK1", "gene_names_refseq": "SGK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase Sgk1 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1257604); (R-SSC-2672351); (R-SSC-6804757); (R-SSC-9031628)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A719", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VDA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VDG8-1", "uniprot_id": "A0A4X1VDG8_PIG", "mass": 56613.0, "length": 511, "protein_name": "Vacuolar proton pump subunit B", "gene_name": "ATP6V1B2", "organism": "Pig", "refseq_name": "V-type proton ATPase subunit B, brain isoform", "refseq_ac": "XP_003483427", "gene_names_uniprotkb": "ATP6V1B2", "gene_names_refseq": "ATP6V1B2", "protein_names_uniprotkb": "Vacuolar proton pump subunit B; V-ATPase subunit B; Vacuolar proton pump subunit B", "protein_names_refseq": "V-type proton ATPase subunit B, brain isoform", "tax_id": 9823, "disease": "", "pathway": " (ssc:106504095); (R-SSC-1222556); (R-SSC-77387); (R-SSC-917977); (R-SSC-9639288); (R-SSC-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480UKG6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VDG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VEM2-1", "uniprot_id": "A0A4X1VEM2_PIG", "mass": 24716.0, "length": 212, "protein_name": "Programmed cell death protein 10", "gene_name": "PDCD10", "organism": "Pig", "refseq_name": "programmed cell death protein 10 isoform X1", "refseq_ac": "XP_005670021", "gene_names_uniprotkb": "PDCD10", "gene_names_refseq": "PDCD10", "protein_names_uniprotkb": "Programmed cell death protein 10", "protein_names_refseq": "programmed cell death protein 10 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480LEG9", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VEM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VFF1-1", "uniprot_id": "A0A4X1VFF1_PIG", "mass": 84813.0, "length": 760, "protein_name": "Neuroendocrine convertase 1", "gene_name": "PCSK1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PCSK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuroendocrine convertase 1; 3.4.21.93; Prohormone convertase 1; Proprotein convertase 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-209952); (R-SSC-422085)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RNV5", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0034774 secretory granule lumen;GO:0043005 neuron projection;GO:0030133 transport vesicle", "go_biological_process": "GO:0016486 peptide hormone processing;GO:0043043 peptide biosynthetic process;GO:0030070 insulin processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VFF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VHW2-1", "uniprot_id": "A0A4X1VHW2_PIG", "mass": 35216.0, "length": 305, "protein_name": "Deoxyribonuclease", "gene_name": "DNASE1L3", "organism": "Pig", "refseq_name": "deoxyribonuclease gamma", "refseq_ac": "XP_020924727", "gene_names_uniprotkb": "DNASE1L3", "gene_names_refseq": "DNASE1L3", "protein_names_uniprotkb": "Deoxyribonuclease", "protein_names_refseq": "deoxyribonuclease gamma", "tax_id": 9823, "disease": "", "pathway": " (ssc:100738010)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, 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cytotoxicity;GO:0006309 apoptotic DNA fragmentation;GO:0010623 programmed cell death involved in cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VHW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VHU4-1", "uniprot_id": "A0A4X1VHU4_PIG", "mass": 24510.0, "length": 215, "protein_name": "Sodium channel regulatory subunit beta-3", "gene_name": "SCN3B", "organism": "Pig", "refseq_name": "sodium channel subunit beta-3 isoform X1", "refseq_ac": "XP_005667503", "gene_names_uniprotkb": "SCN3B", "gene_names_refseq": "SCN3B", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-3", "protein_names_refseq": "sodium channel subunit beta-3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100628130)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, 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"secondary_ac_list": "A0A480L113", "ec_number_list": "", "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "go_cellular_component": "GO:0030018 Z disc;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0072659 protein localization to plasma membrane;GO:0086091 regulation of heart rate by cardiac conduction;GO:0010460 positive regulation of heart rate;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VHU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VML4-1", "uniprot_id": "A0A4X1VML4_PIG", "mass": 87828.0, "length": 760, "protein_name": "Fibroblast activation protein alpha", "gene_name": "FAP", "organism": "Pig", "refseq_name": "prolyl endopeptidase FAP isoform X1", "refseq_ac": "XP_005671941", "gene_names_uniprotkb": "FAP", "gene_names_refseq": "FAP", "protein_names_uniprotkb": "Fibroblast activation protein alpha", "protein_names_refseq": "prolyl endopeptidase FAP isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100736572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "K7GQN2", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0005178 integrin binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0031258 lamellipodium membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0097325 melanocyte proliferation;GO:1902362 melanocyte apoptotic process;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VML4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2Q7I8-1", "uniprot_id": "A0A5G2Q7I8_PIG", "mass": 55168.0, "length": 500, "protein_name": "Twinfilin actin binding protein 2", "gene_name": "TWF2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TWF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Twinfilin actin binding protein 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0030027 lamellipodium", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization;GO:0010976 positive regulation of neuron projection development;GO:0071300 cellular response to retinoic acid;GO:0051016 barbed-end actin filament capping;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q7I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VMY1-1", "uniprot_id": "A0A4X1VMY1_PIG", "mass": 13282.0, "length": 119, "protein_name": "Small nuclear ribonucleoprotein Sm D1", "gene_name": "SNRPD1", "organism": "Pig", "refseq_name": "small nuclear ribonucleoprotein Sm D1 isoform X1", "refseq_ac": "XP_003127902", "gene_names_uniprotkb": "SNRPD1", "gene_names_refseq": "SNRPD1", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D1; snRNP core protein D1", "protein_names_refseq": "small nuclear ribonucleoprotein Sm D1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100524872); (R-SSC-191859); (R-SSC-72163); (R-SSC-72165); (R-SSC-9770562); (R-SSC-9943411)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z5G9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0034709 methylosome;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VMY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VPB2-1", "uniprot_id": "A0A4X1VPB2_PIG", "mass": 72716.0, "length": 633, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "GALNT3", "organism": "Pig", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 3", "refseq_ac": "XP_020930707", "gene_names_uniprotkb": "GALNT3", "gene_names_refseq": "GALNT3", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "polypeptide N-acetylgalactosaminyltransferase 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100515629); (R-SSC-190372); (R-SSC-913709)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZJR1", "ec_number_list": "", "go_molecular_function": "GO:0016740 transferase activity;GO:0030246 carbohydrate binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "A0A4X1VPB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VPR2-1", "uniprot_id": "A0A4X1VPR2_PIG", "mass": 35419.0, "length": 317, "protein_name": "Uridine phosphorylase", "gene_name": "UPP2", "organism": "Pig", "refseq_name": "uridine phosphorylase 2", "refseq_ac": "XP_020932121", "gene_names_uniprotkb": "UPP2", "gene_names_refseq": "UPP2", "protein_names_uniprotkb": "Uridine phosphorylase; 2.4.2.3", "protein_names_refseq": "uridine phosphorylase 2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522709); (R-SSC-73614); (R-SSC-73621)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I3LRA0", "ec_number_list": "", "go_molecular_function": "GO:0004850 uridine phosphorylase activity;GO:0042802 identical protein binding;GO:0009032 thymidine phosphorylase activity;GO:0047847 deoxyuridine phosphorylase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045098 type III intermediate filament", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006218 uridine catabolic process;GO:0044206 UMP salvage;GO:0042178 xenobiotic catabolic process;GO:0006248 CMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VPR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VS06-1", "uniprot_id": "A0A4X1VS06_PIG", "mass": 42645.0, "length": 383, "protein_name": "Apelin receptor", "gene_name": "APLNR", "organism": "Pig", "refseq_name": "apelin receptor", "refseq_ac": "XP_020937674", "gene_names_uniprotkb": "APLNR", "gene_names_refseq": "APLNR", "protein_names_uniprotkb": "Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ", "protein_names_refseq": "apelin receptor", "tax_id": 9823, "disease": "", "pathway": " (ssc:110258749); (R-SSC-375276); (R-SSC-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A9Z5", "ec_number_list": "", "go_molecular_function": "GO:0060182 apelin receptor activity;GO:0140897 mechanoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VS06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W169-1", "uniprot_id": "A0A4X1W169_PIG", "mass": 38645.0, "length": 356, "protein_name": "Stomatin-like protein 2, mitochondrial", "gene_name": "STOML2", "organism": "Pig", "refseq_name": "stomatin-like protein 2, mitochondrial", "refseq_ac": "XP_013841770", "gene_names_uniprotkb": "STOML2", "gene_names_refseq": "STOML2", "protein_names_uniprotkb": "Stomatin-like protein 2, mitochondrial", "protein_names_refseq": "stomatin-like protein 2, mitochondrial", "tax_id": 9823, "disease": "", "pathway": " (ssc:100625031); (R-SSC-9840373)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZSD7", "ec_number_list": "", "go_molecular_function": "GO:0051020 GTPase binding;GO:0042608 T cell receptor binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0010876 lipid localization;GO:1990046 stress-induced mitochondrial fusion;GO:0051259 protein complex oligomerization;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1VZ90-1", "uniprot_id": "A0A4X1VZ90_PIG", "mass": 90545.0, "length": 827, "protein_name": "Microcephalin", "gene_name": "MCPH1", "organism": "Pig", "refseq_name": "microcephalin isoform X1", "refseq_ac": "XP_020931458", "gene_names_uniprotkb": "MCPH1", "gene_names_refseq": "MCPH1", "protein_names_uniprotkb": "Microcephalin", "protein_names_refseq": "microcephalin isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100737787); (R-SSC-2299718)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286ZLF7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1VZ90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W037-1", "uniprot_id": "A0A4X1W037_PIG", "mass": 113632.0, "length": 1016, "protein_name": "Nonsense-mediated mRNA decay factor", "gene_name": "SMG5", "organism": "Pig", "refseq_name": "protein SMG5 isoform X1", "refseq_ac": "XP_020945339", "gene_names_uniprotkb": "SMG5", "gene_names_refseq": "SMG5", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor", "protein_names_refseq": "protein SMG5 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100153097); (R-SSC-975957)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287AHD2", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0042826 histone deacetylase binding;GO:0042162 telomeric DNA binding;GO:0051721 protein phosphatase 2A binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0035303 regulation of dephosphorylation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W0N9-1", "uniprot_id": "A0A4X1W0N9_PIG", "mass": 39385.0, "length": 351, "protein_name": "Short-wave-sensitive opsin 1", "gene_name": "OPN1SW", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "OPN1SW", "gene_names_refseq": "", "protein_names_uniprotkb": "Short-wave-sensitive opsin 1; Blue cone photoreceptor pigment; Blue-sensitive opsin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2187335); (R-SSC-418594); (R-SSC-419771)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SMN2", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W0N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W1R6-1", "uniprot_id": "A0A4X1W1R6_PIG", "mass": 101899.0, "length": 910, "protein_name": "Staphylococcal nuclease domain-containing protein", "gene_name": "SND1", "organism": "Pig", "refseq_name": "staphylococcal nuclease domain-containing protein 1", "refseq_ac": "XP_020934292", "gene_names_uniprotkb": "SND1", "gene_names_refseq": "SND1", "protein_names_uniprotkb": "Staphylococcal nuclease domain-containing protein; 3.1.31.1", "protein_names_refseq": "staphylococcal nuclease domain-containing protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521760)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QLY5", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0004521 RNA endonuclease activity;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0097433 dense body;GO:0031332 RNAi effector complex", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0010564 regulation of cell cycle process;GO:0010587 miRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W1R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W1R9-1", "uniprot_id": "A0A4X1W1R9_PIG", "mass": 83600.0, "length": 749, "protein_name": "Transcription factor RFX3", "gene_name": "RFX3", "organism": "Pig", "refseq_name": "transcription factor RFX3 isoform X4", "refseq_ac": "XP_020919871", "gene_names_uniprotkb": "RFX3", "gene_names_refseq": "RFX3", "protein_names_uniprotkb": "Transcription factor RFX3; Regulatory factor X 3", "protein_names_refseq": "transcription factor RFX3 isoform X4", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287ANK6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0072560 type B pancreatic cell maturation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W1R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W373-1", "uniprot_id": "A0A4X1W373_PIG", "mass": 46695.0, "length": 418, "protein_name": "Inhibitor of growth protein", "gene_name": "ING3", "organism": "Pig", "refseq_name": "inhibitor of growth protein 3", "refseq_ac": "NP_001231197", "gene_names_uniprotkb": "ING3", "gene_names_refseq": "ING3", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth protein 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:100512026)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB, UniProtKB]; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A287A6F4", "ec_number_list": "", "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0032777 piccolo histone acetyltransferase complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051726 regulation of cell cycle;GO:1905168 positive regulation of double-strand break repair via homologous recombination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W373-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W434-1", "uniprot_id": "A0A4X1W434_PIG", "mass": 14311.0, "length": 125, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 1", "gene_name": "BLOC1S1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BLOC1S1", "gene_names_refseq": "", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 1; Protein acetyltransferase BLOC1S1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-432720); (R-SSC-432722)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z5S5", "ec_number_list": "", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005769 early endosome;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0016197 endosomal transport;GO:0048490 anterograde synaptic vesicle transport;GO:0032418 lysosome localization;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W5Z8-1", "uniprot_id": "A0A4X1W5Z8_PIG", "mass": 47230.0, "length": 421, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "gene_name": "PIP4K2C", "organism": "Pig", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "refseq_ac": "XP_020947536", "gene_names_uniprotkb": "PIP4K2C", "gene_names_refseq": "PIP4K2C", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; 2.7.1.149; Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "protein_names_refseq": "phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "tax_id": 9823, "disease": "", "pathway": " (ssc:100520306); (R-SSC-1660499); (R-SSC-6811555); (R-SSC-6811558); (R-SSC-8847453)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480LMF6;F1SKH6", "ec_number_list": "", "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0046488 phosphatidylinositol metabolic process;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W5Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W814-1", "uniprot_id": "A0A4X1W814_PIG", "mass": 25594.0, "length": 227, "protein_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "gene_name": "AK3", "organism": "Pig", "refseq_name": "GTP:AMP phosphotransferase AK3, mitochondrial isoform X1", "refseq_ac": "XP_001924714", "gene_names_uniprotkb": "AK3", "gene_names_refseq": "AK3", "protein_names_uniprotkb": "GTP:AMP phosphotransferase AK3, mitochondrial; 2.7.4.10; AK 3; Adenylate kinase 3 alpha-like 1; Adenylate kinase 3", "protein_names_refseq": "GTP:AMP phosphotransferase AK3, mitochondrial isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100155691); (R-SSC-983231)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QPK4", "ec_number_list": "", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046041 ITP metabolic process;GO:0046051 UTP metabolic process;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W841-1", "uniprot_id": "A0A4X1W841_PIG", "mass": 28266.0, "length": 263, "protein_name": "Lens fiber major intrinsic protein", "gene_name": "MIP", "organism": "Pig", "refseq_name": "lens fiber major intrinsic protein isoform X1", "refseq_ac": "XP_003126321", "gene_names_uniprotkb": "MIP", "gene_names_refseq": "MIP", "protein_names_uniprotkb": "Lens fiber major intrinsic protein; Aquaporin-0", "protein_names_refseq": "lens fiber major intrinsic protein isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522373); (R-SSC-432047)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1SLB5", "ec_number_list": "", "go_molecular_function": "GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0006833 water transport;GO:0036438 maintenance of lens transparency", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A4X1W841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A4X1W9C0-1", "uniprot_id": "A0A4X1W9C0_PIG", "mass": 119074.0, "length": 1056, "protein_name": "[histone H3]-trimethyl-L-lysine(9) demethylase", "gene_name": "KDM4C", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KDM4C", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(9) demethylase; 1.14.11.66", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3214842); (R-SSC-5625886)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB]; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. 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(R-SSC-9909505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0001650 fibrillar center;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0007601 visual perception;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2Q9P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QAK4-1", "uniprot_id": "A0A5G2QAK4_PIG", "mass": 96632.0, "length": 861, "protein_name": "Cysteine--tRNA ligase, cytoplasmic", "gene_name": "CARS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CARS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine--tRNA ligase, cytoplasmic; 6.1.1.16; Cysteinyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0004817 cysteine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QAK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QBM6-1", "uniprot_id": "A0A5G2QBM6_PIG", "mass": 57065.0, "length": 499, "protein_name": "Gamma-aminobutyric acid receptor subunit epsilon", "gene_name": "GABRE", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GABRE", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516716)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:2001226 negative regulation of chloride transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QBM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QBW8-1", "uniprot_id": "A0A5G2QBW8_PIG", "mass": 26871.0, "length": 237, "protein_name": "Phosphomannomutase", "gene_name": "PMM2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PMM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphomannomutase; 5.4.2.8", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-446205)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0061728 GDP-mannose biosynthetic process from mannose;GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QBW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QD06-1", "uniprot_id": "A0A5G2QD06_PIG", "mass": 91554.0, "length": 787, "protein_name": "Nuclear cap-binding protein subunit 1", "gene_name": "NCBP1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NCBP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-111367); (R-SSC-112382); (R-SSC-113418); (R-SSC-159227); (R-SSC-159230); (R-SSC-159231); (R-SSC-159236); (R-SSC-674695); (R-SSC-6803529); (R-SSC-6807505); (R-SSC-72086); (R-SSC-72163); (R-SSC-72165); (R-SSC-72187); (R-SSC-72203); (R-SSC-73856); (R-SSC-77588); (R-SSC-77595); (R-SSC-975956); (R-SSC-975957); (R-SSC-9770562); (R-SSC-9930044)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006406 mRNA export from nucleus;GO:0030307 positive regulation of cell growth;GO:0051607 defense response to virus;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QD06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QD31-1", "uniprot_id": "A0A5G2QD31_PIG", "mass": 63519.0, "length": 583, "protein_name": "Family with sequence similarity 83 member D", "gene_name": "FAM83D", "organism": "Pig", "refseq_name": "protein FAM83D", "refseq_ac": "XP_020933485", "gene_names_uniprotkb": "FAM83D", "gene_names_refseq": "FAM83D", "protein_names_uniprotkb": "Family with sequence similarity 83 member D", "protein_names_refseq": "protein FAM83D", "tax_id": 9823, "disease": "", "pathway": " (ssc:102164658); (R-SSC-177929)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0097431 mitotic spindle pole;GO:0005737 cytoplasm", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QD31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QDA1-1", "uniprot_id": "A0A5G2QDA1_PIG", "mass": 122533.0, "length": 1061, "protein_name": "Toll-like receptor 9", "gene_name": "TLR8", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TLR8", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor 9", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1679131)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0045322 unmethylated CpG binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QDA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QDQ1-1", "uniprot_id": "A0A5G2QDQ1_PIG", "mass": 45102.0, "length": 395, "protein_name": "V-type proton ATPase subunit", "gene_name": "ATP6V0D1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP6V0D1", "gene_names_refseq": "", "protein_names_uniprotkb": "V-type proton ATPase subunit", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1222556); (R-SSC-77387); (R-SSC-917977); (R-SSC-9639288); (R-SSC-983712)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0098793 presynapse;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QDQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QE64-1", "uniprot_id": "A0A5G2QE64_PIG", "mass": 67518.0, "length": 604, "protein_name": "Protein unc-93 homolog B1", "gene_name": "UNC93B1", "organism": "Pig", "refseq_name": "protein unc-93 homolog B1 isoform X1", "refseq_ac": "XP_003122484", "gene_names_uniprotkb": "UNC93B1", "gene_names_refseq": "UNC93B1", "protein_names_uniprotkb": "Protein unc-93 homolog B1", "protein_names_refseq": "protein unc-93 homolog B1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100522238); (R-SSC-1679131)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035325 Toll-like receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0032009 early phagosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0002250 adaptive immune response;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QE64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R2V3-1", "uniprot_id": "A0A5G2R2V3_PIG", "mass": 101634.0, "length": 941, "protein_name": "Histone deacetylase", "gene_name": "HDAC7", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HDAC7", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3108214); (R-SSC-350054)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0032703 negative regulation of interleukin-2 production;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R2V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3R7-1", "uniprot_id": "A0A5G2R3R7_PIG", "mass": 100438.0, "length": 918, "protein_name": "Calcium-transporting ATPase", "gene_name": "ATP2C1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP2C1", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-936837)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0140613 P-type manganese transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network;GO:0033106 cis-Golgi network membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0008544 epidermis development;GO:0030036 actin cytoskeleton organization;GO:0042998 positive regulation of Golgi to plasma membrane protein transport;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0032468 Golgi calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R5Z1-1", "uniprot_id": "A0A5G2R5Z1_PIG", "mass": 181949.0, "length": 1614, "protein_name": "DNA topoisomerase 2", "gene_name": "TOP2B", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TOP2B", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA topoisomerase 2; 5.6.2.2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-4615885)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000792 heterochromatin;GO:0005634 nucleus", "go_biological_process": "GO:0030183 B cell differentiation;GO:0006265 DNA topological change;GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0000712 resolution of meiotic recombination intermediates;GO:0000819 sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R5Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QPE1-1", "uniprot_id": "A0A5G2QPE1_PIG", "mass": 79892.0, "length": 700, "protein_name": "Calpain-2 catalytic subunit", "gene_name": "CAPN2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CAPN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain-2 large subunit; Millimolar-calpain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1474228); (R-SSC-9856530); (R-SSC-9860927)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0071230 cellular response to amino acid stimulus;GO:0051603 proteolysis involved in protein catabolic process;GO:0048488 synaptic vesicle endocytosis;GO:0140249 protein catabolic process at postsynapse;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QPE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RBI3-1", "uniprot_id": "A0A5G2RBI3_PIG", "mass": 75798.0, "length": 672, "protein_name": "Annexin", "gene_name": "ANXA6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ANXA6", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May associate with CD21. May regulate the release of Ca(2+) from intracellular stores., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding;GO:0005525 GTP binding;GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0042470 melanosome;GO:0042584 chromaffin granule membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006816 calcium ion transport;GO:0097190 apoptotic signaling pathway;GO:0051560 mitochondrial calcium ion homeostasis;GO:0051283 negative regulation of sequestering of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RBI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QVW3-1", "uniprot_id": "A0A5G2QVW3_PIG", "mass": 22053.0, "length": 204, "protein_name": "Granulocyte colony-stimulating factor", "gene_name": "CSF3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CSF3", "gene_names_refseq": "", "protein_names_uniprotkb": "Granulocyte colony-stimulating factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0019899 enzyme binding;GO:0005130 granulocyte colony-stimulating factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0071682 endocytic vesicle lumen", "go_biological_process": "GO:0006955 immune response;GO:0045639 positive regulation of myeloid cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QVW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RLJ6-1", "uniprot_id": "A0A5G2RLJ6_PIG", "mass": 84623.0, "length": 757, "protein_name": "Dipeptidyl peptidase 3", "gene_name": "DPP3", "organism": "Pig", "refseq_name": "dipeptidyl peptidase 3 isoform X1", "refseq_ac": "XP_005654711", "gene_names_uniprotkb": "DPP3", "gene_names_refseq": "DPP3", "protein_names_uniprotkb": "Dipeptidyl peptidase 3; 3.4.14.4; Dipeptidyl aminopeptidase III; Dipeptidyl peptidase III", "protein_names_refseq": "dipeptidyl peptidase 3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100519350)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RLJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QVL1-1", "uniprot_id": "A0A5G2QVL1_PIG", "mass": 69360.0, "length": 647, "protein_name": "Polypyrimidine tract-binding protein 1", "gene_name": "PTBP1", "organism": "Pig", "refseq_name": "polypyrimidine tract-binding protein 1 isoform X4", "refseq_ac": "XP_020936997", "gene_names_uniprotkb": "PTBP1", "gene_names_refseq": "PTBP1; PTB", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 1", "protein_names_refseq": "polypyrimidine tract-binding protein 1 isoform X4", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0036002 pre-mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0010629 negative regulation of gene expression;GO:0008380 RNA splicing;GO:1903312 negative regulation of mRNA metabolic process;GO:0075522 IRES-dependent viral translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QVL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QPB9-1", "uniprot_id": "A0A5G2QPB9_PIG", "mass": 93833.0, "length": 816, "protein_name": "Calpain-3", "gene_name": "CAPN3", "organism": "Pig", "refseq_name": "calpain-3 isoform X3", "refseq_ac": "XP_005659762", "gene_names_uniprotkb": "CAPN3", "gene_names_refseq": "CAPN3; SKM; p94", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54", "protein_names_refseq": "calpain-3 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1474228)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0060090 molecular adaptor activity;GO:0008307 structural constituent of muscle;GO:0031432 titin binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0071277 cellular response to calcium ion;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QPB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R2I8-1", "uniprot_id": "A0A5G2R2I8_PIG", "mass": 133660.0, "length": 1210, "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "EGFR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EGFR", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1227986); (R-SSC-1236394); (R-SSC-1250196); (R-SSC-1257604); (R-SSC-177929); (R-SSC-179812); (R-SSC-180292); (R-SSC-180336); (R-SSC-182971); (R-SSC-1963642); (R-SSC-212718); (R-SSC-2179392); (R-SSC-5673001); (R-SSC-6785631); (R-SSC-6811558); (R-SSC-8847993); (R-SSC-8856825); (R-SSC-8856828); (R-SSC-8857538); (R-SSC-8863795)", "pathway_count": 20, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0031965 nuclear membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R2I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QU98-1", "uniprot_id": "A0A5G2QU98_PIG", "mass": 40736.0, "length": 362, "protein_name": "Adenosine deaminase", "gene_name": "ADA", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADA", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0046936 2'-deoxyadenosine deaminase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0060205 cytoplasmic vesicle lumen;GO:0070161 anchoring junction", "go_biological_process": "GO:0006154 adenosine catabolic process;GO:0014074 response to purine-containing compound;GO:0001666 response to hypoxia;GO:0042110 T cell activation;GO:0009168 purine ribonucleoside monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QU98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RJ69-1", "uniprot_id": "A0A5G2RJ69_PIG", "mass": 19890.0, "length": 187, "protein_name": "Alkylglycerone-phosphate synthase", "gene_name": "AGPS", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AGPS", "gene_names_refseq": "", "protein_names_uniprotkb": "Alkylglycerone-phosphate synthase; 2.5.1.26; Alkyl-DHAP synthase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-75896); (R-SSC-9033241)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008609 alkylglycerone-phosphate synthase activity;GO:0071949 FAD binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RJ69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R0F5-1", "uniprot_id": "A0A5G2R0F5_PIG", "mass": 40495.0, "length": 362, "protein_name": "Adenosine kinase", "gene_name": "ADK", "organism": "Pig", "refseq_name": "adenosine kinase isoform X1", "refseq_ac": "XP_003359288", "gene_names_uniprotkb": "ADK", "gene_names_refseq": "ADK", "protein_names_uniprotkb": "Adenosine kinase; 2.7.1.20; AK; Adenosine 5'-phosphotransferase", "protein_names_refseq": "adenosine kinase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154626); (R-SSC-74217); (R-SSC-9755088)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004001 adenosine kinase activity;GO:0046872 metal ion binding;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006169 adenosine salvage;GO:0044209 AMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006144 purine nucleobase metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R0F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R4N4-1", "uniprot_id": "A0A5G2R4N4_PIG", "mass": 69139.0, "length": 616, "protein_name": "RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog", "gene_name": "RPAP2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RPAP2", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog; 3.1.3.16", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517893); (R-SSC-6807505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043175 RNA polymerase core enzyme binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0097550 transcription preinitiation complex;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0009301 snRNA transcription;GO:0036499 PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R4N4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RJL2-1", "uniprot_id": "A0A5G2RJL2_PIG", "mass": 72661.0, "length": 638, "protein_name": "Elongator complex protein 3", "gene_name": "ELP3", "organism": "Pig", "refseq_name": "elongator complex protein 3", "refseq_ac": "XP_020927937", "gene_names_uniprotkb": "ELP3", "gene_names_refseq": "ELP3", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.-", "protein_names_refseq": "elongator complex protein 3", "tax_id": 9823, "disease": "", "pathway": " (ssc:102167101)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Not a major acetyltransferase of tubulin. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex., [UniProtKB, UniProtKB, UniProtKB]; Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0106261 tRNA uridine(34) acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RJL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R5P4-1", "uniprot_id": "A0A5G2R5P4_PIG", "mass": 29906.0, "length": 267, "protein_name": "Multifunctional fusion protein", "gene_name": "IL1B; LOC110258579", "organism": "Pig", "refseq_name": "interleukin-1 beta-like", "refseq_ac": "XP_020937488", "gene_names_uniprotkb": "IL1B; LOC110258579; IL1B; LOC110258579", "gene_names_refseq": "LOC110258579", "protein_names_uniprotkb": "Multifunctional fusion protein", "protein_names_refseq": "interleukin-1 beta-like", "tax_id": 9823, "disease": "", "pathway": " (ssc:110258579)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8D0HYJ4", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R5P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R7R6-1", "uniprot_id": "A0A5G2R7R6_PIG", "mass": 54099.0, "length": 499, "protein_name": "Beta-enolase", "gene_name": "ENO3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENO3", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 3; Muscle-specific enolase; Skeletal muscle enolase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-70171); (R-SSC-70263)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Appears to have a function in striated muscle development and regeneration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0000015 phosphopyruvate hydratase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R7R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R592-1", "uniprot_id": "A0A5G2R592_PIG", "mass": 149589.0, "length": 1306, "protein_name": "Cohesin subunit SA", "gene_name": "STAG1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "STAG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cohesin subunit SA; SCC3 homolog; Stromal antigen", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2467813); (R-SSC-2468052); (R-SSC-2470946); (R-SSC-2500257); (R-SSC-3108214)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0008278 cohesin complex;GO:0016604 nuclear body", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007062 sister chromatid cohesion;GO:0090307 mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R592-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QFZ5-1", "uniprot_id": "A0A5G2QFZ5_PIG", "mass": 98444.0, "length": 914, "protein_name": "E3 ubiquitin-protein ligase ZNRF3", "gene_name": "ZNRF3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ZNRF3", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF3; 2.3.2.27; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-4641263)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005109 frizzled binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0030178 negative regulation of Wnt signaling pathway;GO:2000050 regulation of non-canonical Wnt signaling pathway;GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QFZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QWV3-1", "uniprot_id": "A0A5G2QWV3_PIG", "mass": 59417.0, "length": 541, "protein_name": "Phosphoacetylglucosamine mutase", "gene_name": "PGM3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PGM3", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoacetylglucosamine mutase; 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; PAGM", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-446210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004610 phosphoacetylglucosamine mutase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0030097 hemopoiesis;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QWV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QTD4-1", "uniprot_id": "A0A5G2QTD4_PIG", "mass": 81224.0, "length": 715, "protein_name": "Choline transporter-like protein", "gene_name": "SLC44A2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC44A2", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline transporter-like protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0022857 transmembrane transporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QTD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QXU7-1", "uniprot_id": "A0A5G2QXU7_PIG", "mass": 186070.0, "length": 1662, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAPGEF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; RA-GEF-1; Ras/Rap1-associating GEF-1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0070161 anchoring junction;GO:0098794 postsynapse", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007264 small GTPase-mediated signal transduction;GO:0048022 negative regulation of melanin biosynthetic process;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QXU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RB28-1", "uniprot_id": "A0A5G2RB28_PIG", "mass": 94648.0, "length": 835, "protein_name": "SID1 transmembrane family member 2", "gene_name": "SIDT2", "organism": "Pig", "refseq_name": "SID1 transmembrane family member 2 isoform X4", "refseq_ac": "XP_003129928", "gene_names_uniprotkb": "SIDT2", "gene_names_refseq": "SIDT2", "protein_names_uniprotkb": "SID1 transmembrane family member 2", "protein_names_refseq": "SID1 transmembrane family member 2 isoform X4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100523197)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035612 AP-2 adaptor complex binding;GO:0003725 double-stranded RNA binding;GO:0035650 AP-1 adaptor complex binding;GO:0051033 RNA transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0050658 RNA transport;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RB28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RAC3-1", "uniprot_id": "A0A5G2RAC3_PIG", "mass": 128967.0, "length": 1137, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "ATP8A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP8A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6798695); (R-SSC-936837)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090556 phosphatidylserine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0007612 learning;GO:0030335 positive regulation of cell migration;GO:0045332 phospholipid translocation;GO:0061092 positive regulation of phospholipid translocation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RAC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QUP0-1", "uniprot_id": "A0A5G2QUP0_PIG", "mass": 56578.0, "length": 501, "protein_name": "G protein-activated inward rectifier potassium channel 1", "gene_name": "KCNJ3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KCNJ3", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1296041); (R-SSC-997272)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity", "go_cellular_component": "GO:1990566 I(KACh) inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QUP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R5L9-1", "uniprot_id": "A0A5G2R5L9_PIG", "mass": 37147.0, "length": 340, "protein_name": "Leukocyte surface antigen CD47", "gene_name": "CD47", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CD47", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukocyte surface antigen CD47; Integrin-associated protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070053 thrombospondin receptor activity;GO:0098632 cell-cell adhesion mediator activity;GO:0070051 fibrinogen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0098609 cell-cell adhesion;GO:0050729 positive regulation of inflammatory response;GO:0050766 positive regulation of phagocytosis;GO:0002684 positive regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R5L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QV28-1", "uniprot_id": "A0A5G2QV28_PIG", "mass": 37261.0, "length": 331, "protein_name": "Protein IMPACT", "gene_name": "IMPACT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IMPACT", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein IMPACT", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0043022 ribosome binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045666 positive regulation of neuron differentiation;GO:0006446 regulation of translational initiation;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QV28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R7U8-1", "uniprot_id": "A0A5G2R7U8_PIG", "mass": 58748.0, "length": 529, "protein_name": "Aromatic-L-amino-acid decarboxylase", "gene_name": "DDC", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DDC", "gene_names_refseq": "", "protein_names_uniprotkb": "Aromatic-L-amino-acid decarboxylase; 4.1.1.28; DOPA decarboxylase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-209905); (R-SSC-209931)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004058 aromatic-L-amino-acid decarboxylase activity;GO:0019899 enzyme binding;GO:0036468 L-dopa decarboxylase activity;GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0042423 catecholamine biosynthetic process;GO:0019752 carboxylic acid metabolic process;GO:0042416 dopamine biosynthetic process;GO:0006584 catecholamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R7U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QZI0-1", "uniprot_id": "A0A5G2QZI0_PIG", "mass": 57631.0, "length": 529, "protein_name": "Thymocyte selection associated high mobility group box", "gene_name": "TOX", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Thymocyte selection associated high mobility group box", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment;GO:1902232 regulation of positive thymic T cell selection;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QZI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R2L4-1", "uniprot_id": "A0A5G2R2L4_PIG", "mass": 24066.0, "length": 205, "protein_name": "Core-binding factor subunit beta", "gene_name": "CBFB", "organism": "Pig", "refseq_name": "core-binding factor subunit beta isoform X2", "refseq_ac": "XP_020949712", "gene_names_uniprotkb": "CBFB", "gene_names_refseq": "CBFB", "protein_names_uniprotkb": "Core-binding factor subunit beta; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit", "protein_names_refseq": "core-binding factor subunit beta isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8877330); (R-SSC-8878166); (R-SSC-8931987); (R-SSC-8934593); (R-SSC-8936459); (R-SSC-8939236); (R-SSC-8939243); (R-SSC-8939245); (R-SSC-8939246); (R-SSC-8939247); (R-SSC-8941326); (R-SSC-8941858); (R-SSC-8951936); (R-SSC-9018519)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016513 core-binding factor complex", "go_biological_process": "GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000209 protein polyubiquitination;GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R2L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QPB2-1", "uniprot_id": "A0A5G2QPB2_PIG", "mass": 47770.0, "length": 418, "protein_name": "Sorting nexin", "gene_name": "SNX6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SNX6", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in several stages of intracellular trafficking., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0042803 protein homodimerization activity;GO:0034452 dynactin binding;GO:0034713 type I transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006886 intracellular protein transport;GO:1904646 cellular response to amyloid-beta;GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QPB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RHT4-1", "uniprot_id": "A0A5G2RHT4_PIG", "mass": 47698.0, "length": 428, "protein_name": "Caspase-1", "gene_name": "CASP1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CASP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase-1; 3.4.22.36; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-448706); (R-SSC-5620971); (R-SSC-9968551)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0005576 extracellular region;GO:0097169 AIM2 inflammasome complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RHT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R4C3-1", "uniprot_id": "A0A5G2R4C3_PIG", "mass": 88435.0, "length": 812, "protein_name": "Rho GTPase-activating protein 44", "gene_name": "ARHGAP44", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARHGAP44", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase-activating protein 44; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8980692); (R-SSC-9013148); (R-SSC-9013149)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0043197 dendritic spine;GO:0055037 recycling endosome;GO:0098793 presynapse;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0050804 modulation of chemical synaptic transmission;GO:0061001 regulation of dendritic spine morphogenesis;GO:0035021 negative regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R4C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R9F4-1", "uniprot_id": "A0A5G2R9F4_PIG", "mass": 90638.0, "length": 803, "protein_name": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1", "gene_name": "CALN1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CALN1", "gene_names_refseq": "", "protein_names_uniprotkb": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; 4.1.3.44; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000166 nucleotide binding;GO:0102521 tRNA-4-demethylwyosine synthase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R9F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R7V2-1", "uniprot_id": "A0A5G2R7V2_PIG", "mass": 171331.0, "length": 1506, "protein_name": "[histone H3]-trimethyl-L-lysine(4) demethylase", "gene_name": "KDM5D", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KDM5D", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(4) demethylase; 1.14.11.67", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3214842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0060765 regulation of androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A5G2R7V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R5H9-1", "uniprot_id": "A0A5G2R5H9_PIG", "mass": 58577.0, "length": 556, "protein_name": "H2.0-like homeobox protein", "gene_name": "HLX", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HLX", "gene_names_refseq": "", "protein_names_uniprotkb": "H2.0-like homeobox protein; Homeobox protein HLX1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517234)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. 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9823, "disease": "", "pathway": " (R-SSC-418990); (R-SSC-5218920); (R-SSC-9762292); (R-SSC-9764561); (R-SSC-9766229); (R-SSC-9958810); (R-SSC-9958825)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, 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Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0005545 1-phosphatidylinositol binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0000281 mitotic cytokinesis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QW16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RG64-1", "uniprot_id": "A0A5G2RG64_PIG", "mass": 73451.0, "length": 638, "protein_name": "Poly(A)-specific ribonuclease PARN", "gene_name": "PARN", "organism": "Pig", "refseq_name": "poly(A)-specific ribonuclease PARN isoform X1", "refseq_ac": "XP_020942220", "gene_names_uniprotkb": "PARN", "gene_names_refseq": "PARN", "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PARN; 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SEC31-like protein 1; SEC31-related protein A", "protein_names_refseq": "protein transport protein Sec31A isoform X4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100511210); (R-SSC-204005); (R-SSC-2132295); (R-SSC-983170)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). 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0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0006886 intracellular protein transport;GO:0016477 cell migration;GO:0045987 positive regulation of smooth muscle contraction;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QWJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RCG2-1", "uniprot_id": "A0A5G2RCG2_PIG", "mass": 180336.0, "length": 1646, 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nervous system development;GO:0051239 regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RCG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QGZ1-1", "uniprot_id": "A0A5G2QGZ1_PIG", "mass": 83009.0, "length": 714, "protein_name": "Protein FAM161A", "gene_name": "FAM161A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FAM161A", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein FAM161A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521720)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005814 centriole;GO:0000235 astral microtubule;GO:0005813 centrosome;GO:0001917 photoreceptor inner segment;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030030 cell projection organization;GO:0060271 cilium assembly;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QGZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QXI3-1", "uniprot_id": "A0A5G2QXI3_PIG", "mass": 32947.0, "length": 292, "protein_name": "Caspase-6", "gene_name": "CASP6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CASP6", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase-6; 3.4.22.59", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517293); (R-SSC-111465); (R-SSC-264870); (R-SSC-352238)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0030855 epithelial cell differentiation;GO:0043525 positive regulation of neuron apoptotic process;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QXI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QFX9-1", "uniprot_id": "A0A5G2QFX9_PIG", "mass": 25485.0, "length": 239, "protein_name": "Mannose-binding protein C", "gene_name": "MBL2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MBL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mannose-binding protein C", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-166662)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005537 D-mannose binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway;GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QFX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R0L5-1", "uniprot_id": "A0A5G2R0L5_PIG", "mass": 307491.0, "length": 2773, "protein_name": "Teneurin-2", "gene_name": "TENM2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TENM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Teneurin-2; Protein Odd Oz/ten-m homolog 2; Tenascin-M2; Teneurin transmembrane protein 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Induces gene transcription inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R0L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QSI7-1", "uniprot_id": "A0A5G2QSI7_PIG", "mass": 393902.0, "length": 3431, "protein_name": "Utrophin", "gene_name": "UTRN", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UTRN", "gene_names_refseq": "", "protein_names_uniprotkb": "Utrophin; Dystrophin-related protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9913351)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May play a role in anchoring the cytoskeleton to the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0005178 integrin binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045211 postsynaptic membrane;GO:0032991 protein-containing complex;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0001954 positive regulation of cell-matrix adhesion;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QSI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3A9-1", "uniprot_id": "A0A5G2R3A9_PIG", "mass": 82806.0, "length": 740, "protein_name": "WD repeat-containing protein 48", "gene_name": "WDR48", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WDR48", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 48; USP1-associated factor 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110314); (R-SSC-5689880); (R-SSC-6783310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0043130 ubiquitin binding;GO:0003697 single-stranded DNA binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000724 double-strand break repair via homologous recombination;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R0E8-1", "uniprot_id": "A0A5G2R0E8_PIG", "mass": 116149.0, "length": 1031, "protein_name": "Alpha-mannosidase", "gene_name": "MAN2B1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAN2B1", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6798695); (R-SSC-8853383)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on oligosaccharides generated by N-glycoprotein degradation pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R0E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QHE9-1", "uniprot_id": "A0A5G2QHE9_PIG", "mass": 38428.0, "length": 341, "protein_name": "Mitochondrial fission factor", "gene_name": "MFF", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MFF", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial fission factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission;GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QHE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QNI9-1", "uniprot_id": "A0A5G2QNI9_PIG", "mass": 88601.0, "length": 788, "protein_name": "Interphotoreceptor matrix proteoglycan 1", "gene_name": "IMPG1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IMPG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 1; Sialoprotein associated with cones and rods", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QNI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QHN8-1", "uniprot_id": "A0A5G2QHN8_PIG", "mass": 135211.0, "length": 1252, "protein_name": "Catenin delta 2", "gene_name": "CTNND2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CTNND2", "gene_names_refseq": "", "protein_names_uniprotkb": "Catenin delta 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0070161 anchoring junction;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0060997 dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QHN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R9B1-1", "uniprot_id": "A0A5G2R9B1_PIG", "mass": 60637.0, "length": 541, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 5", "gene_name": "MAP2K5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAP2K5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 5; 2.7.12.2; MAPK/ERK kinase 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005819 spindle", "go_biological_process": "GO:0007254 JNK cascade;GO:0048009 insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R9B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R105-1", "uniprot_id": "A0A5G2R105_PIG", "mass": 147307.0, "length": 1335, "protein_name": "aldehyde oxidase", "gene_name": "AOX4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AOX4", "gene_names_refseq": "", "protein_names_uniprotkb": "aldehyde oxidase; 1.2.3.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0071949 FAD binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0004854 xanthine dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006145 purine nucleobase catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QH34-1", "uniprot_id": "A0A5G2QH34_PIG", "mass": 54639.0, "length": 511, "protein_name": "Dihydrolipoyl dehydrogenase", "gene_name": "DLD", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DLD", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase; 1.8.1.4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-204174); (R-SSC-5362517); (R-SSC-6783984); (R-SSC-70895); (R-SSC-9837999); (R-SSC-9853506); (R-SSC-9858328); (R-SSC-9859138); (R-SSC-9861559)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0045333 cellular respiration;GO:0006103 2-oxoglutarate metabolic process;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QH34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QUZ7-1", "uniprot_id": "A0A5G2QUZ7_PIG", "mass": 52196.0, "length": 477, "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "WIPI1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WIPI1", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1632852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0030136 clathrin-coated vesicle;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0048203 vesicle targeting, trans-Golgi to endosome;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QUZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R4M8-1", "uniprot_id": "A0A5G2R4M8_PIG", "mass": 112940.0, "length": 982, "protein_name": "Transient receptor potential cation channel subfamily C member 4", "gene_name": "TRPC4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRPC4", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily C member 4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3295583)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034703 cation channel complex;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0070588 calcium ion transmembrane transport;GO:0003254 regulation of membrane depolarization;GO:0070509 calcium ion import", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R4M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RAR2-1", "uniprot_id": "A0A5G2RAR2_PIG", "mass": 28990.0, "length": 259, "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "gene_name": "NMNAT3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NMNAT3", "gene_names_refseq": "", "protein_names_uniprotkb": "Nicotinamide-nucleotide adenylyltransferase; 2.7.7.18; 2.7.7.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-196807)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0019363 pyridine nucleotide biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RAR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RMH4-1", "uniprot_id": "A0A5G2RMH4_PIG", "mass": 32975.0, "length": 295, "protein_name": "Transmembrane and immunoglobulin domain-containing protein 1", "gene_name": "TMIGD1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TMIGD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane and immunoglobulin domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521401)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0090559 regulation of membrane permeability;GO:0043066 negative regulation of apoptotic process;GO:0098609 cell-cell adhesion;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RMH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QJ76-1", "uniprot_id": "A0A5G2QJ76_PIG", "mass": 91590.0, "length": 799, "protein_name": "Mitogen-activated protein kinase kinase kinase 20", "gene_name": "MAP3K20", "organism": "Pig", "refseq_name": "mitogen-activated protein kinase kinase kinase MLT isoform X1", "refseq_ac": "XP_013846037", "gene_names_uniprotkb": "MAP3K20", "gene_names_refseq": "MAP3K20", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 20; 2.7.11.25; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; Sterile alpha motif- and leucine zipper-containing kinase AZK", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase MLT isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100152572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha., [UniProtKB, UniProtKB]; Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation. Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6. Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress. May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0000287 magnesium ion binding;GO:0030295 protein kinase activator activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006954 inflammatory response;GO:0043065 positive regulation of apoptotic process;GO:0007254 JNK cascade;GO:0042733 embryonic digit morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QJ76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QYW6-1", "uniprot_id": "A0A5G2QYW6_PIG", "mass": 23201.0, "length": 211, "protein_name": "Eukaryotic translation initiation factor 3 subunit J", "gene_name": "EIF3J", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EIF3J; EIF3S1", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit J; Eukaryotic translation initiation factor 3 subunit 1; eIF-3-alpha; eIF3 p35; eIF3j", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517070); (R-SSC-156827); (R-SSC-72649); (R-SSC-72689); (R-SSC-72695); (R-SSC-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QYW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RIE6-1", "uniprot_id": "A0A5G2RIE6_PIG", "mass": 69533.0, "length": 596, "protein_name": "Outer dynein arm docking complex subunit 3", "gene_name": "ODAD3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ODAD3", "gene_names_refseq": "", "protein_names_uniprotkb": "Outer dynein arm docking complex subunit 3", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0035253 ciliary rootlet;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RIE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QFX3-1", "uniprot_id": "A0A5G2QFX3_PIG", "mass": 20244.0, "length": 181, "protein_name": "Mitochondrial inner membrane protease subunit", "gene_name": "IMMP2L", "organism": "Pig", "refseq_name": "mitochondrial inner membrane protease subunit 2 isoform X1", "refseq_ac": "XP_020934745", "gene_names_uniprotkb": "IMMP2L", "gene_names_refseq": "IMMP2L", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit; 3.4.21.-", "protein_names_refseq": "mitochondrial inner membrane protease subunit 2 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100521052)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0004175 endopeptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QFX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QPU0-1", "uniprot_id": "A0A5G2QPU0_PIG", "mass": 96215.0, "length": 864, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 5", "gene_name": "USP5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "USP5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 5; 3.4.19.12; Deubiquitinating enzyme 5; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5689880); (R-SSC-8866652)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0010494 cytoplasmic stress granule;GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QPU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RE27-1", "uniprot_id": "A0A5G2RE27_PIG", "mass": 37676.0, "length": 323, "protein_name": "B30.2/SPRY domain-containing protein", "gene_name": "LOC106504368", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC106504368", "gene_names_refseq": "", "protein_names_uniprotkb": "B30.2/SPRY domain-containing protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RE27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RB02-1", "uniprot_id": "A0A5G2RB02_PIG", "mass": 39656.0, "length": 358, "protein_name": "Decorin", "gene_name": "DCN", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DCN", "gene_names_refseq": "", "protein_names_uniprotkb": "Decorin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1474228); (R-SSC-1971475); (R-SSC-2022870); (R-SSC-2022923); (R-SSC-2024101); (R-SSC-3000178)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May affect the rate of fibrils formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RB02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QSN6-1", "uniprot_id": "A0A5G2QSN6_PIG", "mass": 104478.0, "length": 903, "protein_name": "Inositol polyphosphate 5-phosphatase OCRL", "gene_name": "OCRL", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "OCRL", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase OCRL; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate 5-phosphatase OCRL-1; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100524726); (R-SSC-1660499); (R-SSC-1660514); (R-SSC-1855183); (R-SSC-1855204); (R-SSC-432722); (R-SSC-8856828); (R-SSC-9013409); (R-SSC-9013423)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005905 clathrin-coated pit;GO:0030670 phagocytic vesicle membrane;GO:0031901 early endosome membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0030030 cell projection organization;GO:0046856 phosphatidylinositol dephosphorylation;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QSN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R924-1", "uniprot_id": "A0A5G2R924_PIG", "mass": 280980.0, "length": 2417, "protein_name": "Spectrin alpha chain, erythrocytic 1", "gene_name": "SPTA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPTA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin alpha chain, erythrocytic 1; Erythroid alpha-spectrin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-375165); (R-SSC-5673001); (R-SSC-6807878)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0016020 membrane;GO:0014731 spectrin-associated cytoskeleton;GO:0008091 spectrin;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R924-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QM52-1", "uniprot_id": "A0A5G2QM52_PIG", "mass": 283762.0, "length": 2545, "protein_name": "Zinc finger FYVE domain-containing protein 26", "gene_name": "ZFYVE26", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ZFYVE26", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 26", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0005764 lysosome;GO:0005770 late endosome;GO:0030496 midbody", "go_biological_process": "GO:0007040 lysosome organization;GO:0000281 mitotic cytokinesis;GO:0000724 double-strand break repair via homologous recombination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QM52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RBI2-1", "uniprot_id": "A0A5G2RBI2_PIG", "mass": 52398.0, "length": 469, "protein_name": "RB binding protein 7, chromatin remodeling factor", "gene_name": "RBBP7", "organism": "Pig", "refseq_name": "histone-binding protein RBBP7 isoform X1", "refseq_ac": "XP_003360284", "gene_names_uniprotkb": "RBBP7", "gene_names_refseq": "RBBP7", "protein_names_uniprotkb": "RB binding protein 7, chromatin remodeling factor", "protein_names_refseq": "histone-binding protein RBBP7 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-212300); (R-SSC-2559580); (R-SSC-3214815); (R-SSC-3214841); (R-SSC-3214847); (R-SSC-3214858); (R-SSC-606279); (R-SSC-6804758); (R-SSC-73762); (R-SSC-8943724); (R-SSC-8951664); (R-SSC-8953750); (R-SSC-9764725); (R-SSC-9909649); (R-SSC-9937850); (R-SSC-9940951)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006325 chromatin organization;GO:0006351 DNA-templated transcription;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RBI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QG47-1", "uniprot_id": "A0A5G2QG47_PIG", "mass": 106678.0, "length": 925, "protein_name": "Nuclear pore complex protein", "gene_name": "NUP107", "organism": "Pig", "refseq_name": "nuclear pore complex protein Nup107 isoform X1", "refseq_ac": "XP_020947628", "gene_names_uniprotkb": "NUP107", "gene_names_refseq": "NUP107", "protein_names_uniprotkb": "Nuclear pore complex protein", "protein_names_refseq": "nuclear pore complex protein Nup107 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100516909); (R-SSC-141430); (R-SSC-141444); (R-SSC-159227); (R-SSC-159230); (R-SSC-159231); (R-SSC-159236); (R-SSC-1855170); (R-SSC-1855196); (R-SSC-1855229); (R-SSC-191859); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-3108214); (R-SSC-3232142); (R-SSC-3301854); (R-SSC-3371453); (R-SSC-4085377); (R-SSC-4551638); (R-SSC-4570464); (R-SSC-4615885); (R-SSC-5663220); (R-SSC-68877); (R-SSC-9615933); (R-SSC-9648025)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0000776 kinetochore;GO:0031080 nuclear pore outer ring;GO:0034399 nuclear periphery", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QG47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RET1-1", "uniprot_id": "A0A5G2RET1_PIG", "mass": 86160.0, "length": 777, "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "organism": "Pig", "refseq_name": "BRCA1-associated RING domain protein 1", "refseq_ac": "XP_020930805", "gene_names_uniprotkb": "BARD1", "gene_names_refseq": "BARD1", "protein_names_uniprotkb": "BRCA1-associated RING domain protein 1; 2.3.2.27; RING-type E3 ubiquitin transferase BARD1", "protein_names_refseq": "BRCA1-associated RING domain protein 1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100511662); (R-SSC-5685938); (R-SSC-5685942); (R-SSC-5689603); (R-SSC-5689901); (R-SSC-5693537); (R-SSC-5693565); (R-SSC-5693568); (R-SSC-5693571); (R-SSC-5693579); (R-SSC-5693607); (R-SSC-5693616); (R-SSC-6804756); (R-SSC-69473)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding;GO:0003723 RNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0070531 BRCA1-A complex;GO:0031436 BRCA1-BARD1 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006301 DNA damage tolerance;GO:0006513 protein monoubiquitination;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RET1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RAB5-1", "uniprot_id": "A0A5G2RAB5_PIG", "mass": 56309.0, "length": 512, "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "TXNRD1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TXNRD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin reductase 1, cytoplasmic; 1.11.1.2; 1.8.1.9; Peroxidase TXNRD1; Thioredoxin reductase TR1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0050660 flavin adenine dinucleotide binding;GO:0050137 NADPH peroxidase activity;GO:0042802 identical protein binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0006979 response to oxidative stress;GO:0034599 cellular response to oxidative stress;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RAB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R0M7-1", "uniprot_id": "A0A5G2R0M7_PIG", "mass": 101088.0, "length": 916, "protein_name": "DNA ligase", "gene_name": "LIG1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LIG1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA ligase; 6.5.1.1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110362); (R-SSC-174414); (R-SSC-5358565); (R-SSC-5358606); (R-SSC-5651801); (R-SSC-5685938); (R-SSC-6782210); (R-SSC-69183)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0051301 cell division;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R0M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QG63-1", "uniprot_id": "A0A5G2QG63_PIG", "mass": 57776.0, "length": 514, "protein_name": "Heparanase", "gene_name": "HPSE", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HPSE", "gene_names_refseq": "", "protein_names_uniprotkb": "Heparanase; 3.2.1.166", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2024096); (R-SSC-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045545 syndecan binding;GO:0030305 heparanase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0031012 extracellular matrix;GO:0045121 membrane raft;GO:0005764 lysosome", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0007160 cell-matrix adhesion;GO:0033690 positive regulation of osteoblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QG63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QG83-1", "uniprot_id": "A0A5G2QG83_PIG", "mass": 56138.0, "length": 487, "protein_name": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "MGAT2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MGAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.143; Beta-1,2-N-acetylglucosaminyltransferase II; GlcNAc-T II; Mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-975578)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QG83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QGM5-1", "uniprot_id": "A0A5G2QGM5_PIG", "mass": 114211.0, "length": 1003, "protein_name": "E3 ubiquitin protein ligase", "gene_name": "RNF40", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNF40", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin protein ligase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8866654)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0033503 HULC complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QGM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QI91-1", "uniprot_id": "A0A5G2QI91_PIG", "mass": 59249.0, "length": 524, "protein_name": "Cytidine and dCMP deaminase domain-containing protein 1", "gene_name": "CDADC1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDADC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytidine and dCMP deaminase domain-containing protein 1; 3.5.4.5; Cytidine deaminase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0061676 importin-alpha family protein binding;GO:0042803 protein homodimerization activity;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070383 DNA cytosine deamination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QI91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QH63-1", "uniprot_id": "A0A5G2QH63_PIG", "mass": 122535.0, "length": 1067, "protein_name": "Ubiquitin conjugation factor E4", "gene_name": "UBE4A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UBE4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin conjugation factor E4; 2.3.2.27; RING-type E3 ubiquitin transferase E4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-983168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A480K9P1", "ec_number_list": "", "go_molecular_function": "GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QH63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RKA4-1", "uniprot_id": "A0A5G2RKA4_PIG", "mass": 182126.0, "length": 1816, "protein_name": "Collagen type XI alpha 1 chain", "gene_name": "COL11A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL11A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen type XI alpha 1 chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1442490); (R-SSC-1650814); (R-SSC-2022090); (R-SSC-3000171); (R-SSC-8948216)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005592 collagen type XI trimer;GO:0005585 collagen type II trimer", "go_biological_process": "GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007601 visual perception;GO:0030199 collagen fibril organization;GO:0048705 skeletal system morphogenesis;GO:0035987 endodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RKA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QMX3-1", "uniprot_id": "A0A5G2QMX3_PIG", "mass": 67686.0, "length": 609, "protein_name": "Replication protein A subunit", "gene_name": "RPA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RPA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Replication protein A subunit", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-110312); (R-SSC-110314); (R-SSC-110320); (R-SSC-174437); (R-SSC-176187); (R-SSC-3108214); (R-SSC-3371453); (R-SSC-5358565); (R-SSC-5358606); (R-SSC-5651801); (R-SSC-5655862); (R-SSC-5656121); (R-SSC-5656169); (R-SSC-5685938); (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5693607); (R-SSC-5696395); (R-SSC-5696397); (R-SSC-5696400); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-6783310); (R-SSC-6804756); (R-SSC-68962); (R-SSC-69166); (R-SSC-69473)", "pathway_count": 27, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0003682 chromatin binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0016605 PML body;GO:0000228 nuclear chromosome;GO:0001673 male germ cell nucleus;GO:0035861 site of double-strand break;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006260 DNA replication;GO:1990166 protein localization to site of double-strand break;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QMX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QHF3-1", "uniprot_id": "A0A5G2QHF3_PIG", "mass": 82077.0, "length": 732, "protein_name": "DNA replication licensing factor MCM5", "gene_name": "MCM5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MCM5", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA replication licensing factor MCM5; 3.6.4.12", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-176187); (R-SSC-68867); (R-SSC-68949); (R-SSC-68962); (R-SSC-69052)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2QIC9;A0A5G2RD38", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex;GO:0005694 chromosome", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QHF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QHR5-1", "uniprot_id": "A0A5G2QHR5_PIG", "mass": 57138.0, "length": 539, "protein_name": "Tricarboxylate transport protein, mitochondrial", "gene_name": "SLC25A1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC25A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tricarboxylate transport protein, mitochondrial; Citrate transport protein; Solute carrier family 25 member 1; Tricarboxylate carrier protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-428643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006843 mitochondrial citrate transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QHR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QIL7-1", "uniprot_id": "A0A5G2QIL7_PIG", "mass": 38267.0, "length": 334, "protein_name": "2'-5'-oligoadenylate synthetase 1", "gene_name": "OAS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "OAS1", "gene_names_refseq": "", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthetase 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0043129 surfactant homeostasis;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QIL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QIP4-1", "uniprot_id": "A0A5G2QIP4_PIG", "mass": 33260.0, "length": 306, "protein_name": "Chymotrypsin-like elastase family member 1", "gene_name": "CELA1", "organism": "Pig", "refseq_name": "chymotrypsin-like elastase family member 1 isoform X1", "refseq_ac": "XP_005655631", "gene_names_uniprotkb": "CELA1", "gene_names_refseq": "CELA1; ELA1; ELS1; Elastase-1", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 1; 3.4.21.36; Elastase-1", "protein_names_refseq": "chymotrypsin-like elastase family member 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Serine proteases that hydrolyze many proteins in addition to elastin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QIP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QIZ1-1", "uniprot_id": "A0A5G2QIZ1_PIG", "mass": 48077.0, "length": 446, "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "gene_name": "DLST", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DLST", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-6783984); (R-SSC-9853506); (R-SSC-9858328)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex;GO:0160167 oxoadipate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QIZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QJ86-1", "uniprot_id": "A0A5G2QJ86_PIG", "mass": 54792.0, "length": 477, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "RNMT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNMT", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; mRNA (guanine-N(7))-methyltransferase; mRNA cap methyltransferase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-72086); (R-SSC-77075)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0001650 fibrillar center;GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QJ86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QJE1-1", "uniprot_id": "A0A5G2QJE1_PIG", "mass": 94976.0, "length": 832, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "PPEF2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PPEF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0070301 cellular response to hydrogen peroxide;GO:0043409 negative regulation of MAPK cascade;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0050906 detection of stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QJE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QJG4-1", "uniprot_id": "A0A5G2QJG4_PIG", "mass": 41049.0, "length": 364, "protein_name": "L-Fucosyltransferase", "gene_name": "FUT1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FUT1", "gene_names_refseq": "", "protein_names_uniprotkb": "L-Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006664 glycolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QJG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QU42-1", "uniprot_id": "A0A5G2QU42_PIG", "mass": 44898.0, "length": 382, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "B4GALT6", "organism": "Pig", "refseq_name": "beta-1,4-galactosyltransferase 6", "refseq_ac": "XP_003127934", "gene_names_uniprotkb": "B4GALT6", "gene_names_refseq": "B4GALT6", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "beta-1,4-galactosyltransferase 6", "tax_id": 9823, "disease": "", "pathway": " (ssc:100517222); (R-SSC-2022854); (R-SSC-913709); (R-SSC-975577); (R-SSC-9840309)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006665 sphingolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QU42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QK51-1", "uniprot_id": "A0A5G2QK51_PIG", "mass": 25207.0, "length": 222, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "NTMT1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NTMT1", "gene_names_refseq": "", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0007059 chromosome segregation;GO:0032259 methylation;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QK51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R6F2-1", "uniprot_id": "A0A5G2R6F2_PIG", "mass": 134618.0, "length": 1175, "protein_name": "Leucine--tRNA ligase, cytoplasmic", "gene_name": "LARS1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LARS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine--tRNA ligase, cytoplasmic; 6.1.1.4; Leucyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-9856649)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004823 leucine-tRNA ligase activity;GO:0005524 ATP binding;GO:0005096 GTPase activator activity;GO:0004819 glutamine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0006429 leucyl-tRNA aminoacylation;GO:1904263 positive regulation of TORC1 signaling;GO:0006425 glutaminyl-tRNA aminoacylation;GO:1990253 cellular response to leucine starvation;GO:0071233 cellular response to L-leucine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R6F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QKN2-1", "uniprot_id": "A0A5G2QKN2_PIG", "mass": 69178.0, "length": 613, "protein_name": "Glomulin, FKBP associated protein", "gene_name": "GLMN", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GLMN", "gene_names_refseq": "", "protein_names_uniprotkb": "Glomulin, FKBP associated protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-983168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005171 hepatocyte growth factor receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0055105 ubiquitin-protein transferase inhibitor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0042130 negative regulation of T cell proliferation;GO:0001819 positive regulation of cytokine production;GO:0042327 positive regulation of phosphorylation;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QKN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QL81-1", "uniprot_id": "A0A5G2QL81_PIG", "mass": 31784.0, "length": 281, "protein_name": "Proteasome subunit alpha type", "gene_name": "PSMA4", "organism": "Pig", "refseq_name": "proteasome subunit alpha type-4 isoform X1", "refseq_ac": "XP_020953951", "gene_names_uniprotkb": "PSMA4", "gene_names_refseq": "PSMA4", "protein_names_uniprotkb": "Proteasome subunit alpha type", "protein_names_refseq": "proteasome subunit alpha type-4 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:397058)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0019773 proteasome core complex, alpha-subunit complex;GO:0005634 nucleus", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QL81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QLN5-1", "uniprot_id": "A0A5G2QLN5_PIG", "mass": 76091.0, "length": 675, "protein_name": "Nucleoporin NDC1", "gene_name": "NDC1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NDC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoporin NDC1; Transmembrane protein 48", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-159227); (R-SSC-159230); (R-SSC-159231); (R-SSC-159236); (R-SSC-1855170); (R-SSC-1855196); (R-SSC-1855229); (R-SSC-191859); (R-SSC-3108214); (R-SSC-3232142); (R-SSC-3301854); (R-SSC-3371453); (R-SSC-4085377); (R-SSC-4551638); (R-SSC-4570464); (R-SSC-4615885); (R-SSC-9615933)", "pathway_count": 17, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005643 nuclear pore", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0015031 protein transport;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport;GO:0051664 nuclear pore localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QLN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QLR1-1", "uniprot_id": "A0A5G2QLR1_PIG", "mass": 180664.0, "length": 1603, "protein_name": "Mitogen-activated protein kinase kinase kinase 4", "gene_name": "MAP3K4", "organism": "Pig", "refseq_name": "mitogen-activated protein kinase kinase kinase 4 isoform X1", "refseq_ac": "XP_020941883", "gene_names_uniprotkb": "MAP3K4", "gene_names_refseq": "MAP3K4", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 4; 2.7.11.25; MAPK/ERK kinase kinase 4", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 4 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900745 positive regulation of p38MAPK cascade;GO:0010225 response to UV-C;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QLR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QM06-1", "uniprot_id": "A0A5G2QM06_PIG", "mass": 314152.0, "length": 2910, "protein_name": "Fibrillin-2", "gene_name": "FBN2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FBN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrillin-2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1474228); (R-SSC-1566948); (R-SSC-2129379)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively., [UniProtKB, UniProtKB]; Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels., [UniProtKB, UniProtKB]; Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0048048 embryonic eye morphogenesis;GO:0030501 positive regulation of bone mineralization;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QM06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QM69-1", "uniprot_id": "A0A5G2QM69_PIG", "mass": 54166.0, "length": 500, "protein_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "gene_name": "NAF1", "organism": "Pig", "refseq_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform X1", "refseq_ac": "XP_003129062", "gene_names_uniprotkb": "NAF1", "gene_names_refseq": "NAF1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "protein_names_refseq": "H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100518673)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:0005634 nucleus", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0001522 pseudouridine synthesis;GO:1905323 telomerase holoenzyme complex assembly;GO:0090669 telomerase RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QM69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QMD9-1", "uniprot_id": "A0A5G2QMD9_PIG", "mass": 151324.0, "length": 1355, "protein_name": "Partitioning defective 3 homolog", "gene_name": "PARD3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PARD3", "gene_names_refseq": "", "protein_names_uniprotkb": "Partitioning defective 3 homolog; Atypical PKC isotype-specific-interacting protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2173791); (R-SSC-420029)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0005938 cell cortex;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0008104 intracellular protein localization;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QMD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RCQ6-1", "uniprot_id": "A0A5G2RCQ6_PIG", "mass": 159775.0, "length": 1452, "protein_name": "[histone H3]-trimethyl-L-lysine(27) demethylase", "gene_name": "KDM6A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KDM6A", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(27) demethylase; 1.14.11.68", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-3214842)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0071558 histone H3K27me2/H3K27me3 demethylase activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0007507 heart development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RCQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QML5-1", "uniprot_id": "A0A5G2QML5_PIG", "mass": 28166.0, "length": 253, "protein_name": "Myogenic factor", "gene_name": "MYF5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYF5", "gene_names_refseq": "", "protein_names_uniprotkb": "Myogenic factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-525793)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation;GO:0048743 positive regulation of skeletal muscle fiber development;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QML5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QMX0-1", "uniprot_id": "A0A5G2QMX0_PIG", "mass": 15129.0, "length": 143, "protein_name": "Histone H2A", "gene_name": "H2AX", "organism": "Pig", "refseq_name": "H2A.X variant histone", "refseq_ac": "NP_001422336", "gene_names_uniprotkb": "H2AX", "gene_names_refseq": "H2AX", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "H2A.X variant histone; 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Dystrophy-associated fer-1-like protein; Fer-1-like protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0012505 endomembrane system;GO:0015630 microtubule cytoskeleton;GO:0030659 cytoplasmic vesicle membrane;GO:0030315 T-tubule;GO:0005769 early endosome", "go_biological_process": "GO:0050765 negative regulation of phagocytosis;GO:0002281 macrophage activation involved in immune response;GO:0002280 monocyte activation involved in immune response;GO:0001778 plasma membrane repair;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QU72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QPW2-1", "uniprot_id": "A0A5G2QPW2_PIG", "mass": 81106.0, "length": 741, "protein_name": "Solute carrier family 26 member 5", "gene_name": "SLC26A5", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC26A5", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 26 member 5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030507 spectrin binding;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane;GO:0120249 lateral wall of outer hair cell;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0007605 sensory perception of sound;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QPW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3U7-1", "uniprot_id": "A0A5G2R3U7_PIG", "mass": 59496.0, "length": 515, "protein_name": "Histone H4 transcription factor", "gene_name": "HINFP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HINFP", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H4 transcription factor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015030 Cajal body", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RF15-1", "uniprot_id": "A0A5G2RF15_PIG", "mass": 25808.0, "length": 231, "protein_name": "DNA-directed RNA polymerase subunit", "gene_name": "POLR2G", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POLR2G", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerase subunit", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-112382); (R-SSC-113418); (R-SSC-5578749); (R-SSC-674695); (R-SSC-6781823); (R-SSC-6782135); (R-SSC-6782210); (R-SSC-6796648); (R-SSC-6803529); (R-SSC-6807505); (R-SSC-72086); (R-SSC-72163); (R-SSC-72165); (R-SSC-72203); (R-SSC-73776); (R-SSC-73779); (R-SSC-75953); (R-SSC-75955); (R-SSC-76042); (R-SSC-77075); (R-SSC-9018519); (R-SSC-9770562)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA., [UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003727 single-stranded RNA binding;GO:0003697 single-stranded DNA binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000428 DNA-directed RNA polymerase complex;GO:0000932 P-body;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006352 DNA-templated transcription initiation;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RF15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QQ68-1", "uniprot_id": "A0A5G2QQ68_PIG", "mass": 39776.0, "length": 362, "protein_name": "Rab-interacting lysosomal protein", "gene_name": "RILP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RILP", "gene_names_refseq": "", "protein_names_uniprotkb": "Rab-interacting lysosomal protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2132295)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding;GO:0032935 sterol sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0042632 cholesterol homeostasis;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QQ68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2RBN0-1", "uniprot_id": "A0A5G2RBN0_PIG", "mass": 46378.0, "length": 414, "protein_name": "WW domain-containing oxidoreductase", "gene_name": "WWOX", "organism": "Pig", "refseq_name": "WW domain-containing oxidoreductase isoform X1", "refseq_ac": "XP_020952713", "gene_names_uniprotkb": "WWOX", "gene_names_refseq": "WWOX", "protein_names_uniprotkb": "WW domain-containing oxidoreductase", "protein_names_refseq": "WW domain-containing oxidoreductase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1251985); (R-SSC-8866904); (R-SSC-8866907)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005923 bicellular tight junction;GO:0005764 lysosome;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2RBN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QQG6-1", "uniprot_id": "A0A5G2QQG6_PIG", "mass": 78329.0, "length": 677, "protein_name": "Kinetochore protein NDC80", "gene_name": "NDC80", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NDC80", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinetochore protein NDC80", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-141430); (R-SSC-141444); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-5663220); (R-SSC-68877); (R-SSC-9648025)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051301 cell division;GO:0000132 establishment of mitotic spindle orientation;GO:0007052 mitotic spindle organization;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QQG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QQW0-1", "uniprot_id": "A0A5G2QQW0_PIG", "mass": 37505.0, "length": 325, "protein_name": "Calcium uniporter protein", "gene_name": "MCU", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MCU", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium uniporter protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8949215); (R-SSC-8949664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015292 uniporter activity", "go_cellular_component": "GO:1990246 uniplex complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QQW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QR34-1", "uniprot_id": "A0A5G2QR34_PIG", "mass": 53071.0, "length": 482, "protein_name": "6-phosphogluconate dehydrogenase, decarboxylating", "gene_name": "PGD", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PGD", "gene_names_refseq": "", "protein_names_uniprotkb": "6-phosphogluconate dehydrogenase, decarboxylating; 1.1.1.44", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-71336)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0019521 D-gluconate metabolic process;GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QR34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QS63-1", "uniprot_id": "A0A5G2QS63_PIG", "mass": 360426.0, "length": 3171, "protein_name": "Vacuolar protein sorting 13 homolog A", "gene_name": "VPS13A", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VPS13A", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting 13 homolog A", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0043025 neuronal cell body;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0045053 protein retention in Golgi apparatus;GO:0006914 autophagy;GO:1905146 lysosomal protein catabolic process;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QS63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QRB2-1", "uniprot_id": "A0A5G2QRB2_PIG", "mass": 76498.0, "length": 689, "protein_name": "Phosphatase and actin regulator 4", "gene_name": "PHACTR4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PHACTR4", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatase and actin regulator 4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0061386 closure of optic fissure;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QRB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QRH6-1", "uniprot_id": "A0A5G2QRH6_PIG", "mass": 86532.0, "length": 790, "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARNT", "gene_names_refseq": "", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-1234158); (R-SSC-211945); (R-SSC-211976); (R-SSC-211981); (R-SSC-8937144); (R-SSC-9768919)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0034751 aryl hydrocarbon receptor complex;GO:0034753 nuclear aryl hydrocarbon receptor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia;GO:0010575 positive regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QRH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QSA8-1", "uniprot_id": "A0A5G2QSA8_PIG", "mass": 34848.0, "length": 326, "protein_name": "DNA repair protein", "gene_name": "RAD51D; RFFL", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAD51D; RFFL; RAD51D", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5693568); (R-SSC-5693579); (R-SSC-5693616)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding;GO:0000400 four-way junction DNA binding;GO:0008094 ATP-dependent activity, acting on DNA;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005657 replication fork;GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0007131 reciprocal meiotic recombination;GO:0042148 DNA strand invasion;GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QSA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R1U3-1", "uniprot_id": "A0A5G2R1U3_PIG", "mass": 53116.0, "length": 469, "protein_name": "Stress-activated protein kinase JNK", "gene_name": "MAPK10", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAPK10", "gene_names_refseq": "", "protein_names_uniprotkb": "Stress-activated protein kinase JNK; 2.7.11.24", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2559580); (R-SSC-2871796); (R-SSC-450321); (R-SSC-450341)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity;GO:0004705 JUN kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048511 rhythmic process;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R1U3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QSI4-1", "uniprot_id": "A0A5G2QSI4_PIG", "mass": 65579.0, "length": 572, "protein_name": "Interleukin-1 receptor type 1", "gene_name": "IL1R1", "organism": "Pig", "refseq_name": "interleukin-1 receptor type 1 isoform X1", "refseq_ac": "XP_013851373", "gene_names_uniprotkb": "IL1R1", "gene_names_refseq": "IL1R1", "protein_names_uniprotkb": "Interleukin-1 receptor type 1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; p80", "protein_names_refseq": "interleukin-1 receptor type 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100626904); (R-SSC-9020702)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. 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"", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045766 positive regulation of angiogenesis;GO:0030334 regulation of cell migration;GO:0043536 positive regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QUY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QVF3-1", "uniprot_id": "A0A5G2QVF3_PIG", "mass": 46343.0, "length": 437, "protein_name": "Runt-related transcription factor", "gene_name": "RUNX3", "organism": "Pig", "refseq_name": "runt-related transcription factor 3 isoform X2", "refseq_ac": "XP_020951251", "gene_names_uniprotkb": "RUNX3", "gene_names_refseq": "RUNX3", "protein_names_uniprotkb": "Runt-related transcription factor", "protein_names_refseq": "runt-related transcription factor 3 isoform X2", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8941855); (R-SSC-8941856); (R-SSC-8941858); (R-SSC-8951430); (R-SSC-8951671); (R-SSC-8951936)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QVF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2REW3-1", "uniprot_id": "A0A5G2REW3_PIG", "mass": 102557.0, "length": 910, "protein_name": "E3 ubiquitin-protein ligase MARCHF6", "gene_name": "MARCHF6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MARCHF6", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF6; 2.3.2.27; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:1990381 ubiquitin-specific protease binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2REW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R693-1", "uniprot_id": "A0A5G2R693_PIG", "mass": 52822.0, "length": 483, "protein_name": "Tubulin beta chain", "gene_name": "TUBB3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TUBB3", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin beta chain", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-190840); (R-SSC-2132295); (R-SSC-2467813); (R-SSC-2500257); (R-SSC-3371497); (R-SSC-380320); (R-SSC-5610787); (R-SSC-5620920); (R-SSC-5620924); (R-SSC-5626467); (R-SSC-5663220); (R-SSC-6807878); (R-SSC-6811434); (R-SSC-68877); (R-SSC-8852276); (R-SSC-8955332); (R-SSC-9646399); (R-SSC-9648025); (R-SSC-9668328); (R-SSC-983189); (R-SSC-9833482)", "pathway_count": 21, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:1990890 netrin receptor binding", "go_cellular_component": "GO:0005874 microtubule;GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0030425 dendrite", "go_biological_process": "GO:0007017 microtubule-based process;GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance;GO:1990791 dorsal root ganglion development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R693-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QWD8-1", "uniprot_id": "A0A5G2QWD8_PIG", "mass": 36380.0, "length": 336, "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "LDLRAP1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LDLRAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Low density lipoprotein receptor adapter protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8856825); (R-SSC-8856828); (R-SSC-8964026); (R-SSC-8964038)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding;GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0009898 cytoplasmic side of plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0031623 receptor internalization;GO:0042632 cholesterol homeostasis;GO:0042982 amyloid precursor protein metabolic process;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QWD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QXI1-1", "uniprot_id": "A0A5G2QXI1_PIG", "mass": 129793.0, "length": 1169, "protein_name": "Double-stranded RNA-specific adenosine deaminase", "gene_name": "ADAR", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADAR", "gene_names_refseq": "", "protein_names_uniprotkb": "Double-stranded RNA-specific adenosine deaminase; 3.5.4.37", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-75102); (R-SSC-77042); (R-SSC-9833482)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0044530 supraspliceosomal complex;GO:0031981 nuclear lumen", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QXI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QYQ2-1", "uniprot_id": "A0A5G2QYQ2_PIG", "mass": 120797.0, "length": 1085, "protein_name": "Transcription elongation factor SPT5", "gene_name": "SUPT5H", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SUPT5H", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription elongation factor SPT5", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-112382); (R-SSC-113418); (R-SSC-674695); (R-SSC-6796648); (R-SSC-6807505); (R-SSC-72086); (R-SSC-75955); (R-SSC-77075)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0032044 DSIF complex;GO:0031090 organelle membrane;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016239 positive regulation of macroautophagy;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QYQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2QZT2-1", "uniprot_id": "A0A5G2QZT2_PIG", "mass": 71316.0, "length": 648, "protein_name": "p-selectin", "gene_name": "SELP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SELP", "gene_names_refseq": "", "protein_names_uniprotkb": "p-selectin; CD62 antigen-like family member P; Granule membrane protein 140; Leukocyte-endothelial cell adhesion molecule 3; Platelet activation dependent granule-external membrane protein", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-114608)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0031092 platelet alpha granule membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0033623 regulation of integrin activation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2QZT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R074-1", "uniprot_id": "A0A5G2R074_PIG", "mass": 87233.0, "length": 791, "protein_name": "Zinc phosphodiesterase ELAC protein 2", "gene_name": "ELAC2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ELAC2", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 2; 3.1.26.11; ElaC homolog protein 2; Ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005634 nucleus", "go_biological_process": "GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3M0-1", "uniprot_id": "A0A5G2R3M0_PIG", "mass": 80865.0, "length": 729, "protein_name": "Triadin", "gene_name": "TRDN", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRDN", "gene_names_refseq": "", "protein_names_uniprotkb": "Triadin", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2672351); (R-SSC-5578775)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0005886 plasma membrane;GO:0014701 junctional sarcoplasmic reticulum membrane", "go_biological_process": "GO:0051282 regulation of sequestering of calcium ion;GO:0060047 heart contraction;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0086036 regulation of cardiac muscle cell membrane potential;GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R0V1-1", "uniprot_id": "A0A5G2R0V1_PIG", "mass": 66740.0, "length": 582, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "GALNT4", "organism": "Pig", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 4", "refseq_ac": "XP_003360781", "gene_names_uniprotkb": "GALNT4", "gene_names_refseq": "GALNT4", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "polypeptide N-acetylgalactosaminyltransferase 4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100621801); (R-SSC-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "A0A5G2R0V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R118-1", "uniprot_id": "A0A5G2R118_PIG", "mass": 52742.0, "length": 469, "protein_name": "Sorting nexin-17", "gene_name": "SNX17", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SNX17", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-17", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0032456 endocytic recycling;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R2F8-1", "uniprot_id": "A0A5G2R2F8_PIG", "mass": 169798.0, "length": 1527, "protein_name": "Multidrug resistance-associated protein 1", "gene_name": "ABCC3", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ABCC3", "gene_names_refseq": "", "protein_names_uniprotkb": "Multidrug resistance-associated protein 1; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; Leukotriene C(4) transporter", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-159418); (R-SSC-382556); (R-SSC-9749641); (R-SSC-9753281)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0015164 glucuronoside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006855 xenobiotic transmembrane transport;GO:0071716 leukotriene transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R2F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R2G0-1", "uniprot_id": "A0A5G2R2G0_PIG", "mass": 239123.0, "length": 2142, "protein_name": "Oxygen-regulated protein 1", "gene_name": "RP1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxygen-regulated protein 1; Retinitis pigmentosa RP1 protein homolog", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0001917 photoreceptor inner segment;GO:0005875 microtubule associated complex;GO:0005930 axoneme;GO:0032391 photoreceptor connecting cilium;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R2G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3T7-1", "uniprot_id": "A0A5G2R3T7_PIG", "mass": 134691.0, "length": 1227, "protein_name": "Integrin subunit alpha L", "gene_name": "ITGAL", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ITGAL", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin subunit alpha L", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-198933); (R-SSC-202733); (R-SSC-216083); (R-SSC-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030369 ICAM-3 receptor activity;GO:0038023 signaling receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0034687 integrin alphaL-beta2 complex;GO:0008305 integrin complex", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033631 cell-cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3W4-1", "uniprot_id": "A0A5G2R3W4_PIG", "mass": 35378.0, "length": 309, "protein_name": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "gene_name": "ADPRM", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADPRM", "gene_names_refseq": "", "protein_names_uniprotkb": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; 3.6.1.13; 3.6.1.16; 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2393930)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0047734 CDP-glycerol diphosphatase activity;GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R3Z5-1", "uniprot_id": "A0A5G2R3Z5_PIG", "mass": 8553.0, "length": 77, "protein_name": "Apelin", "gene_name": "APLN", "organism": "Pig", "refseq_name": "apelin", "refseq_ac": "XP_003360494", "gene_names_uniprotkb": "APLN", "gene_names_refseq": "APLN", "protein_names_uniprotkb": "Apelin; APJ endogenous ligand", "protein_names_refseq": "apelin", "tax_id": 9823, "disease": "", "pathway": " (ssc:100625006); (R-SSC-375276); (R-SSC-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031704 apelin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001525 angiogenesis;GO:0010629 negative regulation of gene expression;GO:1904022 positive regulation of G protein-coupled receptor internalization;GO:0060976 coronary vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R3Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R599-1", "uniprot_id": "A0A5G2R599_PIG", "mass": 53146.0, "length": 461, "protein_name": "Alpha-L-fucosidase", "gene_name": "FUCA2", "organism": "Pig", "refseq_name": "plasma alpha-L-fucosidase isoform X1", "refseq_ac": "XP_020927993", "gene_names_uniprotkb": "FUCA2", "gene_names_refseq": "FUCA2", "protein_names_uniprotkb": "Alpha-L-fucosidase; 3.2.1.51", "protein_names_refseq": "plasma alpha-L-fucosidase isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154940); (R-SSC-381426); (R-SSC-6798695); (R-SSC-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0009617 response to bacterium;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R599-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R5K2-1", "uniprot_id": "A0A5G2R5K2_PIG", "mass": 81123.0, "length": 732, "protein_name": "BR serine/threonine kinase 2", "gene_name": "BRSK2", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BRSK2", "gene_names_refseq": "", "protein_names_uniprotkb": "BR serine/threonine kinase 2", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007409 axonogenesis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0030036 actin cytoskeleton organization;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R5K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R616-1", "uniprot_id": "A0A5G2R616_PIG", "mass": 93145.0, "length": 836, "protein_name": "Exonuclease 1", "gene_name": "EXO1", "organism": "Pig", "refseq_name": "exonuclease 1 isoform X1", "refseq_ac": "XP_003130603", "gene_names_uniprotkb": "EXO1", "gene_names_refseq": "EXO1", "protein_names_uniprotkb": "Exonuclease 1; 3.1.-.-", "protein_names_refseq": "exonuclease 1 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100512301); (R-SSC-5358565); (R-SSC-5685938); (R-SSC-5685942); (R-SSC-5693537); (R-SSC-5693568); (R-SSC-5693579); (R-SSC-5693607); (R-SSC-5693616); (R-SSC-6804756); (R-SSC-69473)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006310 DNA recombination;GO:0006298 mismatch repair;GO:0051321 meiotic cell cycle;GO:0002376 immune system process;GO:0110025 DNA strand resection involved in replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R616-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R6M1-1", "uniprot_id": "A0A5G2R6M1_PIG", "mass": 212950.0, "length": 1845, "protein_name": "Unconventional myosin-Vb", "gene_name": "MYO5B", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYO5B", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Vb", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-432040)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0016459 myosin complex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R6M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R6N0-1", "uniprot_id": "A0A5G2R6N0_PIG", "mass": 53442.0, "length": 461, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-1", "gene_name": "GABRR1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GABRR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-977443)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R6N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R6P1-1", "uniprot_id": "A0A5G2R6P1_PIG", "mass": 34169.0, "length": 299, "protein_name": "SPARC", "gene_name": "SPARC", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPARC", "gene_names_refseq": "", "protein_names_uniprotkb": "SPARC; Basement-membrane protein 40; Osteonectin; Secreted protein acidic and rich in cysteine", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-114608); (R-SSC-3000497)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0016363 nuclear matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0048752 semicircular canal morphogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R6P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R728-1", "uniprot_id": "A0A5G2R728_PIG", "mass": 237688.0, "length": 2069, "protein_name": "Unconventional myosin-X", "gene_name": "MYO10", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYO10", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-X; Unconventional myosin-10", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-2029482)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030027 lamellipodium;GO:0043025 neuronal cell body;GO:0030175 filopodium", "go_biological_process": "GO:0008360 regulation of cell shape;GO:0051489 regulation of filopodium assembly;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R7J7-1", "uniprot_id": "A0A5G2R7J7_PIG", "mass": 67385.0, "length": 614, "protein_name": "G protein-coupled receptor 37", "gene_name": "GPR37", "organism": "Pig", "refseq_name": "prosaposin receptor GPR37", "refseq_ac": "XP_003134766", "gene_names_uniprotkb": "GPR37", "gene_names_refseq": "GPR37", "protein_names_uniprotkb": "G protein-coupled receptor 37", "protein_names_refseq": "prosaposin receptor GPR37", "tax_id": 9823, "disease": "", "pathway": " (ssc:100523220); (R-SSC-375276); (R-SSC-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036505 prosaposin receptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0016358 dendrite development;GO:0043410 positive regulation of MAPK cascade;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R7J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R836-1", "uniprot_id": "A0A5G2R836_PIG", "mass": 130423.0, "length": 1175, "protein_name": "Integrin alpha-1", "gene_name": "ITGA1", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ITGA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-216083); (R-SSC-445355)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity;GO:0038023 signaling receptor activity;GO:0098639 collagen binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0045178 basal part of cell;GO:0009897 external side of plasma membrane;GO:0034665 integrin alpha1-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0098609 cell-cell adhesion;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R8E6-1", "uniprot_id": "A0A5G2R8E6_PIG", "mass": 50486.0, "length": 456, "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "organism": "Pig", "refseq_name": "equilibrative nucleoside transporter 2 isoform X4", "refseq_ac": "XP_003122535", "gene_names_uniprotkb": "SLC29A2", "gene_names_refseq": "SLC29A2", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 2; Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2", "protein_names_refseq": "equilibrative nucleoside transporter 2 isoform X4", "tax_id": 9823, "disease": "", "pathway": " (ssc:100518596); (R-SSC-83936); (R-SSC-9748787)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter. Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites. Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity;GO:0015207 adenine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015862 uridine transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0015853 adenine transport;GO:0015854 guanine transport;GO:0035344 hypoxanthine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R8E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R8T9-1", "uniprot_id": "A0A5G2R8T9_PIG", "mass": 104687.0, "length": 927, "protein_name": "Complement component C6", "gene_name": "C6", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "C6", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement component C6", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-166665); (R-SSC-977606)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0045766 positive regulation of angiogenesis;GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0001970 positive regulation of activation of membrane attack complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R8T9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R9F5-1", "uniprot_id": "A0A5G2R9F5_PIG", "mass": 106718.0, "length": 939, "protein_name": "MORC family CW-type zinc finger 3", "gene_name": "MORC3", "organism": "Pig", "refseq_name": "MORC family CW-type zinc finger protein 3 isoform X1", "refseq_ac": "XP_003132812", "gene_names_uniprotkb": "MORC3", "gene_names_refseq": "MORC3", "protein_names_uniprotkb": "MORC family CW-type zinc finger 3", "protein_names_refseq": "MORC family CW-type zinc finger protein 3 isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:100513379)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body;GO:0000785 chromatin;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032688 negative regulation of interferon-beta production;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A5G2R9F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A5G2R9H4-1", "uniprot_id": "A0A5G2R9H4_PIG", "mass": 97103.0, "length": 869, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "MUSK", "organism": "Pig", "refseq_name": "muscle, skeletal receptor tyrosine-protein kinase isoform X3", "refseq_ac": "XP_020930102", "gene_names_uniprotkb": "MUSK", "gene_names_refseq": "MUSK", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 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the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003684 damaged DNA binding;GO:0003690 double-stranded DNA binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FNR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8D1TQR3-1", "uniprot_id": "A0A8D1TQR3_PIG", "mass": 56776.0, "length": 504, "protein_name": "Amine oxidase", "gene_name": "MAOB", "organism": "Pig", "refseq_name": "amine oxidase [flavin-containing] B isoform X1", "refseq_ac": "XP_013841525", "gene_names_uniprotkb": "MAOB", "gene_names_refseq": "MAOB", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "amine oxidase [flavin-containing] B isoform X1", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-141333)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "K7GKH7", "ec_number_list": "", "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0006576 biogenic amine metabolic process;GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8D1TQR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4FGG4-1", "uniprot_id": "A0A8W4FGG4_PIG", "mass": 69504.0, "length": 601, "protein_name": "Formin-binding protein 1-like", "gene_name": "FNBP1L", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FNBP1L", "gene_names_refseq": "", "protein_names_uniprotkb": "Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-8856828); (R-SSC-9013148)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0010324 membrane invagination;GO:0007165 signal transduction;GO:0006914 autophagy;GO:0006900 vesicle budding from membrane;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FGG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4FI15-1", "uniprot_id": "A0A8W4FI15_PIG", "mass": 49058.0, "length": 445, "protein_name": "Signal recognition particle 54 kDa protein", "gene_name": "SRP54", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SRP54", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal recognition particle 54 kDa protein; 3.6.5.-", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100154361); (R-SSC-1799339)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043021 ribonucleoprotein complex binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FI15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1RKF2-1", "uniprot_id": "F1RKF2_PIG", "mass": 160924.0, "length": 1434, "protein_name": "Nitric oxide synthase", "gene_name": "NOS1", "organism": "Pig", "refseq_name": "nitric oxide synthase, brain isoform X2", "refseq_ac": "XP_020928358", "gene_names_uniprotkb": "NOS1", "gene_names_refseq": "NOS1", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "nitric oxide synthase, brain isoform X2", "tax_id": 9823, "disease": "", "pathway": " (ssc:100520934); (R-SSC-1222556); (R-SSC-392154); (R-SSC-5578775)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0043197 dendritic spine;GO:0005901 caveola", "go_biological_process": "GO:0001666 response to hypoxia;GO:0042311 vasodilation;GO:0045893 positive regulation of DNA-templated transcription;GO:0071363 cellular response to growth factor stimulus;GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1RKF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4FA09-1", "uniprot_id": "A0A8W4FA09_PIG", "mass": 152805.0, "length": 1362, "protein_name": "Vascular endothelial growth factor receptor 3", "gene_name": "FLT4", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FLT4", "gene_names_refseq": "", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 3; 2.7.10.1; Fms-like tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-195399)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FA09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8D1R1E7-1", "uniprot_id": "A0A8D1R1E7_PIG", "mass": 32067.0, "length": 288, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PNP", "gene_names_refseq": "", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine-guanosine phosphorylase", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": " (ssc:100157138); (R-SSC-6798695); (R-SSC-74217); (R-SSC-74259); (R-SSC-9755088)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5G2R9A1", "ec_number_list": "", "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0042802 identical protein binding;GO:0001882 nucleoside binding;GO:0002060 purine nucleobase binding;GO:0004731 purine-nucleoside phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006955 immune response;GO:0006157 deoxyadenosine catabolic process;GO:0009410 response to xenobiotic stimulus;GO:0006166 purine ribonucleoside salvage;GO:0032743 positive regulation of interleukin-2 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8D1R1E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4FNC3-1", "uniprot_id": "A0A8W4FNC3_PIG", "mass": 53972.0, "length": 490, "protein_name": "Metal cation symporter ZIP14", "gene_name": "SLC39A14", "organism": "Pig", "refseq_name": "zinc transporter ZIP14 isoform X3", "refseq_ac": "XP_005657292", "gene_names_uniprotkb": "SLC39A14", "gene_names_refseq": "SLC39A14", "protein_names_uniprotkb": "Metal cation symporter ZIP14; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14", "protein_names_refseq": "zinc transporter ZIP14 isoform X3", "tax_id": 9823, "disease": "", "pathway": " (R-SSC-442380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015086 cadmium ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0015296 monoatomic anion:monoatomic cation symporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0071333 cellular response to glucose stimulus;GO:0006882 intracellular zinc ion homeostasis;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FNC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4F920-1", "uniprot_id": "A0A8W4F920_PIG", "mass": 113177.0, "length": 1022, "protein_name": "Protein transport protein sec16", "gene_name": "SEC16B", "organism": "Pig", "refseq_name": "protein transport protein Sec16B isoform X1", "refseq_ac": "XP_020919350", "gene_names_uniprotkb": "SEC16B", "gene_names_refseq": "SEC16B", "protein_names_uniprotkb": "Protein transport protein sec16", "protein_names_refseq": "protein transport protein Sec16B isoform X1", "tax_id": 9823, "disease": "", "pathway": " (ssc:102164898); (R-SSC-204005)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007031 peroxisome organization;GO:0016192 vesicle-mediated transport;GO:0010628 positive regulation of gene expression;GO:0016559 peroxisome fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4F920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8W4FG82-1", "uniprot_id": "A0A8W4FG82_PIG", "mass": 32825.0, "length": 298, "protein_name": "Carbonyl reductase (NADPH)", "gene_name": "LOC110256481", "organism": "Pig", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC110256481", "gene_names_refseq": "", "protein_names_uniprotkb": "Carbonyl reductase (NADPH); 1.1.1.184", "protein_names_refseq": "", "tax_id": 9823, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "32543654", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0050221 prostaglandin E2 9-reductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8W4FG82-1", "record_type": "protein" } ]