[ { "uniprot_canonical_ac": "O70228-1", "uniprot_id": "ATP9A_MOUSE", "mass": 118609.0, "length": 1047, "protein_name": "Probable phospholipid-transporting ATPase IIA", "gene_name": "Atp9a", "organism": "Mouse", "refseq_name": "probable phospholipid-transporting ATPase IIA isoform 1", "refseq_ac": "NP_056546", "gene_names_uniprotkb": "Atp9a", "gene_names_refseq": "Atp9a; IIa", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IIA; 7.6.2.1; ATPase class II type 9A", "protein_names_refseq": "ATPase 9A, class II; ATPase 9A, p type; ATPase, class 2; probable phospholipid-transporting ATPase IIA isoform 1; probable phospholipid-transporting ATPase IIA", "tax_id": 10090, "disease": "neurodevelopmental disorder with poor growth and behavioral abnormalities (Disease Ontology:DOID:0081444)", "pathway": " (mmu:11981); (R-MMU-936837)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11015572;21750661;30084848;34428180;36604604;9548971", "class_list": "", "function": "Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (By similarity). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved. Required for the maintenance of neurite morphology and synaptic transmission (PubMed:36604604)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDI5;Q922L9", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0002020 protease binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006897 endocytosis;GO:0048812 neuron projection morphogenesis;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1903542 negative regulation of exosomal secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O70228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XF90-1", "uniprot_id": "AT134_MOUSE", "mass": 132804.0, "length": 1193, "protein_name": "Probable cation-transporting ATPase 13A4", "gene_name": "Atp13a4", "organism": "Mouse", "refseq_name": "probable cation-transporting ATPase 13A4 isoform 3", "refseq_ac": "NP_001158085", "gene_names_uniprotkb": "Atp13a4", "gene_names_refseq": "4631413J11Rik; 4832416L12; 9330174J19Rik; Atp13a4", "protein_names_uniprotkb": "Probable cation-transporting ATPase 13A4; 7.2.2.-; P5-ATPase isoform 4", "protein_names_refseq": "P5-ATPase; probable cation-transporting ATPase 13A4 isoform 3; probable cation-transporting ATPase 13A4; type V P-type ATPase", "tax_id": 10090, "disease": "Kufor-Rakeb syndrome (Disease Ontology:DOID:0060556); juvenile-onset Parkinson's disease (Disease Ontology:DOID:0060893); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:224079); (R-MMU-936837)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15381061;19731010;21750661;29505581", "class_list": "", "function": "Data suggest that ATP13A4 may play a vital role in the developing nervous system and its impairment can contribute to the symptoms seen in autism spectrum disorder., [RefSeq, PubMed]; Probable polyamine transporter mediating cellular uptake of putrescine, spermidine and spermine (By similarity). May be involved in the regulation of intracellular calcium levels (PubMed:19731010)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80V28;Q8C105;Q8C184", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;7.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:1902047 polyamine transmembrane transport;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5XF90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MK8-1", "uniprot_id": "GRK2_MOUSE", "mass": 79639.0, "length": 689, "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "Grk2", "organism": "Mouse", "refseq_name": "beta-adrenergic receptor kinase 1 isoform 1", "refseq_ac": "NP_001277747", "gene_names_uniprotkb": "Grk2; Adrbk1", "gene_names_refseq": "Adrbk-1; Adrbk1; Bark-1; Grk2; beta ARK; betaARK1", "protein_names_uniprotkb": "G protein-coupled receptor kinase 2; 2.7.11.15; 2.7.11.16; Beta-ARK-1; Beta-adrenergic receptor kinase 1", "protein_names_refseq": "adrenergic receptor kinase, beta 1; beta-AR kinase-1; beta-adrenergic receptor kinase 1 isoform 1; beta-adrenergic receptor kinase 1", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); impotence (Disease Ontology:DOID:1875); opiate dependence (Disease Ontology:DOID:2559); pituitary adenoma (Disease Ontology:DOID:3829); hyperglycemia (Disease Ontology:DOID:4195); liver cirrhosis (Disease Ontology:DOID:5082); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:110355); (R-MMU-111933); (R-MMU-416476); (R-MMU-418555); (R-MMU-5635838); (R-MMU-8856825)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "16452087;18056263;21183079;21750661;23467820;26740625;26932512;28381559;30284927;31219806;31447681;33886552;36210013;37173348;38159884;38242702;38883814;39138140;39627609;8638670", "class_list": "", "function": "GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. Publication Status: Online-Only, [RefSeq, PubMed]; GRK2-YAP signaling is implicated in pulmonary arterial hypertension development., [RefSeq, PubMed]; Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice., [RefSeq, PubMed]; Overexpression of GRK2 in vascular smooth muscle leads to inappropriate hypertension and acute heart failure as in clinical scenario 1. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:18056263, PubMed:30284927, PubMed:38883814, PubMed:33886552). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:18056263, PubMed:30284927, PubMed:38883814, PubMed:33886552). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (PubMed:18056263). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (PubMed:33886552, PubMed:39138140). Also positively regulates SMO signaling by mediating phosphorylation of GPR161, a key inhibitor SMO signaling, promoting ciliary export of GPR161 (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LL8", "ec_number_list": "2.7.11.16;2.7.11.-;2.7.11.13;3.6.5.-;2.7.10.2;2.7.11.15;2.7.11.1", "go_molecular_function": "GO:0031851 kappa-type opioid receptor binding;GO:0031850 delta-type opioid receptor binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0010661 positive regulation of muscle cell apoptotic process;GO:0006468 protein phosphorylation;GO:0006979 response to oxidative stress;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99MK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTZ4-1", "uniprot_id": "APC5_MOUSE", "mass": 83098.0, "length": 740, "protein_name": "Anaphase-promoting complex subunit 5", "gene_name": "Anapc5", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 5 isoform b", "refseq_ac": "NP_001035956", "gene_names_uniprotkb": "Anapc5; MNCb-2778", "gene_names_refseq": "2510006G12Rik; APC5; Anapc5; Anpc5", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5", "protein_names_refseq": "anaphase-promoting complex subunit 5 isoform b; cyclosome subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:59008); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 5, "publication_id_list": "21750661;23922952;25605945;31219806;34428180", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGA7;Q80UJ6;Q80W43;Q8BWW7;Q8C0F7;Q9CRX0;Q9CSL1;Q9JJB8", "ec_number_list": "", "go_molecular_function": "GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BTZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06797-1", "uniprot_id": "CATL1_MOUSE", "mass": 37547.0, "length": 334, "protein_name": "Procathepsin L", "gene_name": "Ctsl", "organism": "Mouse", "refseq_name": "procathepsin L isoform 1 preproprotein", "refseq_ac": "NP_034114", "gene_names_uniprotkb": "Ctsl; Ctsl1", "gene_names_refseq": "1190035F06Rik; CatL; Ctsl1; Ctsl; MEP; fs; nkt", "protein_names_uniprotkb": "Procathepsin L; 3.4.22.15; Cathepsin L1; MEP; Major excreted protein; p39 cysteine proteinase", "protein_names_refseq": "Cat L; cathepsin L1; major excreted protein; p39 cysteine proteinase; procathepsin L isoform 1 preproprotein; procathepsin L", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); otitis media (Disease Ontology:DOID:10754); nephrotic syndrome (Disease Ontology:DOID:1184); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13039); (R-MMU-1442490); (R-MMU-1679131); (R-MMU-2022090); (R-MMU-2024096); (R-MMU-2132295); (R-MMU-8939242); (R-MMU-9766229); (R-MMU-9958810)", "pathway_count": 9, "publication_count": 30, "publication_id_list": "10.1101/2023.09.13.557529;10516062;10716919;11483509;11972068;12021314;12163394;12417635;12782676;12869695;15099520;16170054;21750661;2275556;22872234;25428506;2835398;30899004;34428180;3533924;36038449;36206719;3689328;3755373;37828378;40021952;40885482;8554545;9079717;9545226", "class_list": "", "function": "Cathepsin L was involved in vascular aging by mediating phenotypic transformation of vascular cells., [RefSeq, PubMed]; Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity., [RefSeq, PubMed]; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells (PubMed:12021314). Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed:9545226). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed:12417635). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function (PubMed:11972068). Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed:12163394). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91UZ0", "ec_number_list": "3.4.22.27;3.4.22.34;3.4.22.15;3.4.22.1;3.4.16.5;3.4.16.-;3.4.23.5;3.4.24.17;3.4.24.-;3.4.24.65;3.4.24.35;3.4.22.38;3.4.23.34;3.4.14.1;3.4.24.23;3.2.1.166;3.4.22.42;2.3.2.27;3.4.22.41", "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0051384 response to glucocorticoid;GO:0008584 male gonad development;GO:0010839 negative regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P06797-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07076-1", "uniprot_id": "ANXA7_MOUSE", "mass": 49925.0, "length": 463, "protein_name": "Annexin A7", "gene_name": "Anxa7", "organism": "Mouse", "refseq_name": "annexin A7 isoform 1", "refseq_ac": "NP_001104264", "gene_names_uniprotkb": "Anxa7; Anx7", "gene_names_refseq": "Anx7; Anxa7; synexin", "protein_names_uniprotkb": "Annexin A7; Annexin VII; Annexin-7; Synexin", "protein_names_refseq": "annexin A7 isoform 1; annexin VII; annexin-7", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); amyotrophic lateral sclerosis type 23 (Disease Ontology:DOID:0080225); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); skin cancer (Disease Ontology:DOID:4159)", "pathway": " (mmu:11750)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;25428507;26740625;29783989;30084848;32775428;33811915;34176316;34260942;34428180;35820727;36288343;37453647;40684658;7916616", "class_list": "glycogene", "function": "ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+) Release in Arterial Thrombosis., [RefSeq, PubMed]; AnnexinA7 positively regulates expression levels of SDF1/CXCR4 Publication Status: Online-Only, [RefSeq, PubMed]; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis., [UniProtKB, UniProtKB, UniProtKB]; Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling. Publication Status: Online-Only, [RefSeq, PubMed]; ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT33", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0008283 cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0051592 response to calcium ion;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q07076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZQ9-1", "uniprot_id": "BBS5_MOUSE", "mass": 38862.0, "length": 341, "protein_name": "BBSome complex member BBS5", "gene_name": "Bbs5", "organism": "Mouse", "refseq_name": "BBSome complex member BBS5 isoform 1", "refseq_ac": "NP_082560", "gene_names_uniprotkb": "Bbs5", "gene_names_refseq": "1700049I01Rik; 2700023J09Rik; Bbs5", "protein_names_uniprotkb": "BBSome complex member BBS5; Bardet-Biedl syndrome 5 protein homolog", "protein_names_refseq": "BBSome complex member BBS5 isoform 1; BBSome complex member BBS5; bardet-Biedl syndrome 5 protein homolog; novel DUF1448 protein", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 5 (Disease Ontology:DOID:0110127); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:72569); (R-MMU-5620922)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15137946;21750661;22072986;25428506;30084848;32776140;33560420;34203471", "class_list": "", "function": "A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities., [RefSeq, PubMed]; BBSome Component BBS5 Is Required for Cone Photoreceptor Protein Trafficking and Outer Segment Maintenance., [RefSeq, PubMed]; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUC7", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CZQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BNJ2-1", "uniprot_id": "ATS4_MOUSE", "mass": 90070.0, "length": 833, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "gene_name": "Adamts4", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein", "refseq_ac": "NP_766433", "gene_names_uniprotkb": "Adamts4", "gene_names_refseq": "ADAM-TS4; ADAMTS-2; ADMP-1; Adamts4", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 4; 3.4.24.82; ADAM-TS 4; ADAM-TS4; ADAMTS-4; Aggrecanase-1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; aggrecanase-1", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); rheumatoid arthritis (Disease Ontology:DOID:7148); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (mmu:240913); (R-MMU-1474228); (R-MMU-5173214)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23233679;37859693;38461223", "class_list": "", "function": "ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition. Publication Status: Online-Only, [RefSeq, PubMed]; Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases., [UniProtKB, UniProtKB]; Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K384", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0002020 protease binding;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016607 nuclear speck;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0042742 defense response to bacterium;GO:0030167 proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BNJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V12-1", "uniprot_id": "BACH_MOUSE", "mass": 42537.0, "length": 381, "protein_name": "Cytosolic acyl coenzyme A thioester hydrolase", "gene_name": "Acot7", "organism": "Mouse", "refseq_name": "cytosolic acyl coenzyme A thioester hydrolase isoform 3", "refseq_ac": "NP_001139530", "gene_names_uniprotkb": "Acot7; Bach", "gene_names_refseq": "2410041A17Rik; Ach1; Acot7; Act; Bach; CTE-IIa; Cte-II; Lach1", "protein_names_uniprotkb": "Cytosolic acyl coenzyme A thioester hydrolase; 3.1.2.2; Acyl-CoA thioesterase 7; BACH; Brain acyl-CoA hydrolase; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase", "protein_names_refseq": "50-kDa brain acyl-CoA hydrolase; brain acyl-CoA hydrolase; cytosolic acyl coenzyme A thioester hydrolase isoform 3; cytosolic acyl coenzyme A thioester hydrolase; long chain acyl-CoA thioester hydrolase", "tax_id": 10090, "disease": "", "pathway": " (mmu:70025); (R-MMU-77289)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11834298;12435388;14729242;15288813;17563367;21750661;22645316;28135057;28416579;31039008;33300544", "class_list": "", "function": "Acot7, a fatty acid metabolic enzyme highly enriched in neurons, regulates both brain-specific metabolic processes related to seizure susceptibility and the whole body response to dietary lipid, [RefSeq, PubMed]; Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (Probable). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells, [RefSeq, PubMed]; MBACH cDNA encoded a 338-AA pp >95% identical to human and rat homologs. mBACH was distributed throughboth central and peripheral cell body and neurites. Another 50-kDa pp made from mBACH mRNA used different in-frame ATGs as initiation codon., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A8K9;A2A8L0;A2A8L2;Q3U8C6;Q59HQ2", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;7.6.2.-;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;3.5.2.6;2.3.1.16;2.3.1.9;3.1.2.14;2.3.1.65", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043005 neuron projection", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process;GO:0015937 coenzyme A biosynthetic process;GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:0036116 long-chain fatty-acyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91V12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35381-1", "uniprot_id": "AN32A_MOUSE", "mass": 28538.0, "length": 247, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "Anp32a", "organism": "Mouse", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1", "refseq_ac": "NP_033802", "gene_names_uniprotkb": "Anp32a; Anp32; Lanp", "gene_names_refseq": "Anp32a; Anp32; I1PP2A; LANP; PHAP1; pp32", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; LANP; Leucine-rich acidic nuclear protein; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A", "protein_names_refseq": "acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:11737); (R-MMU-450520)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12807913;15060138;15895553;17557114;19524510;21750661;29467488;30084848;34428180;36370958;37074204;37507081;38421166;8970164;9353121", "class_list": "", "function": "Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage., [RefSeq, PubMed]; Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus., [RefSeq, PubMed]; Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:29467488). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (By similarity) (PubMed:17557114, PubMed:29467488)., [UniProtKB, PubMed, UniProtKB, PubMed]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97437", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0050839 cell adhesion molecule binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0042981 regulation of apoptotic process;GO:0031400 negative regulation of protein modification process;GO:0120033 negative regulation of plasma membrane bounded cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PZM4-1", "uniprot_id": "CHD2_MOUSE", "mass": 210804.0, "length": 1827, "protein_name": "ATP-dependent chromatin remodeler CHD2", "gene_name": "Chd2", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD2", "refseq_ac": "NP_001074814", "gene_names_uniprotkb": "Chd2", "gene_names_refseq": "2810013C04Rik; 2810040A01Rik; 5630401D06Rik; CHD-2; Chd2", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD2; 3.6.4.-; CHD-2; Chromo domain-containing protein 2", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD2; ATP-dependent helicase CHD2; chromo domain-containing protein 2", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); developmental and epileptic encephalopathy 94 (Disease Ontology:DOID:0081325); prostate cancer (Disease Ontology:DOID:10283); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:244059)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16810678;19137022;19142019;21183079;21750661;22569126", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression., [UniProtKB, PubMed]; Chd2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymphomas., [RefSeq, PubMed]; Our results demonstrate that mutation of Chd2 dramatically affects mammalian development and long-term survival. Erratum:[J Cell Physiol. 2007 Aug;212(2):562], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006351 DNA-templated transcription;GO:0060218 hematopoietic stem cell differentiation;GO:0006974 DNA damage response;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9PZM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57110-1", "uniprot_id": "ATS8_MOUSE", "mass": 98880.0, "length": 905, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 8", "gene_name": "Adamts8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adamts8", "gene_names_refseq": "", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 8; 3.4.24.-; ADAM-TS 8; ADAM-TS8; ADAMTS-8; METH-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-5173214)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10610729;21750661", "class_list": "", "function": "Has anti-angiogenic properties., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P57110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4H4-1", "uniprot_id": "AMOL1_MOUSE", "mass": 107950.0, "length": 968, "protein_name": "Angiomotin-like protein 1", "gene_name": "Amotl1", "organism": "Mouse", "refseq_name": "angiomotin-like protein 1", "refseq_ac": "NP_001074864", "gene_names_uniprotkb": "Amotl1", "gene_names_refseq": "2310010G08Rik; 2310067L22Rik; 4932416D09Rik; Amotl1; JEAP; mFLJ00155", "protein_names_uniprotkb": "Angiomotin-like protein 1; JEAP; junction-enriched and -associated protein", "protein_names_refseq": "angiomotin-like protein 1; junction-enriched and -associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75723); (R-MMU-2028269)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11733531;17397395;21183079;21750661;30375152;34428180", "class_list": "", "function": "Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1., [RefSeq, PubMed]; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKN5;Q571F1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030027 lamellipodium;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D4H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98195-1", "uniprot_id": "ATP9B_MOUSE", "mass": 129017.0, "length": 1146, "protein_name": "Probable phospholipid-transporting ATPase IIB", "gene_name": "Atp9b", "organism": "Mouse", "refseq_name": "probable phospholipid-transporting ATPase IIB isoform 1", "refseq_ac": "NP_001188498", "gene_names_uniprotkb": "Atp9b", "gene_names_refseq": "Atp9b; Atpc2b; IIb; MMR", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IIB; 7.6.2.1; ATPase class II type 9B", "protein_names_refseq": "ATPase 9B, class II; ATPase 9B, p type; ATPase, class 2, member b; macrophage MHC receptor; probable phospholipid-transporting ATPase IIB isoform 1; probable phospholipid-transporting ATPase IIB", "tax_id": 10090, "disease": "", "pathway": " (mmu:50771); (R-MMU-936837)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11015572;21750661;25428506;26495903;28011936;30084848;30779550;31219806;31599954;34428180;35688320;35820727;37828378", "class_list": "", "function": "Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68FM3;Q99LI3", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015914 phospholipid transport;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P98195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VVW5-1", "uniprot_id": "ANPRB_MOUSE", "mass": 117060.0, "length": 1047, "protein_name": "Atrial natriuretic peptide receptor 2", "gene_name": "Npr2", "organism": "Mouse", "refseq_name": "atrial natriuretic peptide receptor 2 isoform 1 precursor", "refseq_ac": "NP_776149", "gene_names_uniprotkb": "Npr2", "gene_names_refseq": "GC-B2; GC-B3; GC-B; Npr2; cn; mNPR-B; pwe", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 2; 4.6.1.2; ANP-B; ANPR-B; Atrial natriuretic peptide receptor type B; GC-B; Guanylate cyclase B; NPR-B", "protein_names_refseq": "ANP-B; ANPR-B; NPR-B; Nppb receptor; atrial natriuretic peptide receptor 2 isoform 1 precursor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor type B; guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type", "tax_id": 10090, "disease": "Miura type epiphyseal chondrodysplasia (Disease Ontology:DOID:0070316); bone development disease (Disease Ontology:DOID:0080006); acromesomelic dysplasia, Maroteaux type (Disease Ontology:DOID:0080050); essential hypertension (Disease Ontology:DOID:10825); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (mmu:230103); (R-MMU-5578768)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14514678;15572448;21750661;25428506;39927985", "class_list": "", "function": "Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B1AWI8;Q6VVW3;Q6VVW4;Q8CGA9", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0045202 synapse", "go_biological_process": "GO:0030540 female genitalia development;GO:0035483 gastric emptying;GO:0001964 startle response;GO:0060466 activation of meiosis involved in egg activation;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6VVW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XL1-1", "uniprot_id": "CBLC_MOUSE", "mass": 55715.0, "length": 496, "protein_name": "E3 ubiquitin-protein ligase CBL-C", "gene_name": "Cblc", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase CBL-C isoform 1", "refseq_ac": "NP_075713", "gene_names_uniprotkb": "Cblc; Cbl3", "gene_names_refseq": "2310076I21Rik; 2310079L19Rik; Cbl3; Cblc", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL-C; 2.3.2.27; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C", "protein_names_refseq": "CBL-3; Casitas B-lineage lymphoma c; E3 ubiquitin-protein ligase CBL-C isoform 1; E3 ubiquitin-protein ligase CBL-C; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:80794)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11162497;11964285;14560016;21750661;24425877;31260484;34428180;36210013", "class_list": "", "function": "Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages, [RefSeq, PubMed]; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival., [UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB]; Only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51, [RefSeq, PubMed]; Results describe the detailed expression pattern of murine Cbl-3 and report the generation and characterization of Cbl-3-deficient mice., [RefSeq, PubMed]; We identified a novel cDNA that was isolated from a mouse mammary cancer from the C3(1) Large T Antigen transgenic model. This mutant cDNA encodes a protein that has a deletion in the RF domain of Cbl-c, thereby resembling known Cbl family mutations associated with myeoloid neoplasias. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99PB6;Q9D6L2;Q9D7A9", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0005509 calcium ion binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80XL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQE6-1", "uniprot_id": "ASF1A_MOUSE", "mass": 22943.0, "length": 204, "protein_name": "Histone chaperone ASF1A", "gene_name": "Asf1a", "organism": "Mouse", "refseq_name": "histone chaperone ASF1A", "refseq_ac": "NP_079817", "gene_names_uniprotkb": "Asf1a", "gene_names_refseq": "2310079C17Rik; Asf1a", "protein_names_uniprotkb": "Histone chaperone ASF1A; Anti-silencing function protein 1 homolog A", "protein_names_refseq": "ASF1 anti-silencing function 1 homolog A; anti-silencing function protein 1 homolog A; histone chaperone ASF1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66403); (R-MMU-2559584)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20021694;21750661;21987787;25428506;29915027;30084848;31744829;31916576;34906203", "class_list": "", "function": "Anti-silencing factor 1A is associated with genome stability maintenance of mouse preimplantation embryosdagger., [RefSeq, PubMed]; Asf1a-mediated nucleosome disassembly provides a means for resolution of bivalent domain barriers for induction of lineage-specific genes during differentiation., [RefSeq, PubMed]; Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit., [UniProtKB, UniProtKB]; In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma., [RefSeq, PubMed]; Tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0001649 osteoblast differentiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JY1-1", "uniprot_id": "TIRAP_MOUSE", "mass": 26035.0, "length": 241, "protein_name": "Toll/interleukin-1 receptor domain-containing adapter protein", "gene_name": "Tirap", "organism": "Mouse", "refseq_name": "toll/interleukin-1 receptor domain-containing adapter protein", "refseq_ac": "NP_473437", "gene_names_uniprotkb": "Tirap; Mal", "gene_names_refseq": "C130027E04Rik; Mal; Tirap; Tlr4ap; Wyatt", "protein_names_uniprotkb": "Toll/interleukin-1 receptor domain-containing adapter protein; Adaptor protein Wyatt; MyD88 adapter-like protein; TIR domain-containing adapter protein", "protein_names_refseq": "TIR domain-containing adapter protein; Toll-like receptor 4 adaptor protein; adaptor protein Wyatt; myD88 adapter-like protein; toll/interleukin-1 receptor domain-containing adapter protein", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:117149); (R-MMU-166058)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11526399;11923871;12072368;12421970;21750661;22187460;35089323;36792369;36888688;38229002", "class_list": "", "function": "ALKBH5-mediated m[6] A demethylation of TIRAP mRNA promotes radiation-induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma., [RefSeq, PubMed]; Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response., [UniProtKB, UniProtKB]; Adapter involved in the TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF and interleukin-6 (By similarity)., [UniProtKB, UniProtKB]; CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP., [RefSeq, PubMed]; Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4., [RefSeq, PubMed]; TIRAP drives myelosuppression through an Ifngamma-Hmgb1 axis that disrupts the endothelial niche in mice., [RefSeq, PubMed]; The adapter MyD88-adapter-like (Mal) is recruited specifically by TLR-4. The set of genes being induced may be tailored for the subsequent elimination of the pathogen being recognized, due to differences in signal transduction pathways activated by TLRs. Review article, [RefSeq, PubMed]; The induction of IL-6 gene expression in macrophages via Tlr4 is TIRAP-dependent., [RefSeq, PubMed]; Tirap controls Mycobacterium tuberculosis phagosomal acidification. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZW0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0032648 regulation of interferon-beta production;GO:0071221 cellular response to bacterial lipopeptide;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99JY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2X0-1", "uniprot_id": "ANR39_MOUSE", "mass": 19639.0, "length": 183, "protein_name": "Ankyrin repeat domain-containing protein 39", "gene_name": "Ankrd39", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 39 isoform 2", "refseq_ac": "NP_001297462", "gene_names_uniprotkb": "Ankrd39", "gene_names_refseq": "9130416N05Rik; Ankrd39; C030004B10Rik", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 39", "protein_names_refseq": "ankyrin repeat domain-containing protein 39 isoform 2; ankyrin repeat domain-containing protein 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:109346)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60007-1", "uniprot_id": "APC15_MOUSE", "mass": 15378.0, "length": 132, "protein_name": "Anaphase-promoting complex subunit 15", "gene_name": "Anapc15", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 15 isoform a", "refseq_ac": "NP_001278277", "gene_names_uniprotkb": "Anapc15; 3200002M19Rik", "gene_names_refseq": "3200002M19Rik; 6330414C15Rik; APC15; Anapc15", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 15; APC15", "protein_names_refseq": "anaphase prompoting complex C subunit 15; anaphase-promoting complex subunit 15 isoform a; anaphase-promoting complex subunit 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:75430); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "21750661;25605945;34428180", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Also required for degradation of CDC20 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT90;Q3UXV5;Q9CXK2;Q9Y269", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M6Y5-1", "uniprot_id": "DEUP1_MOUSE", "mass": 69678.0, "length": 601, "protein_name": "Deuterosome assembly protein 1", "gene_name": "Deup1", "organism": "Mouse", "refseq_name": "deuterosome assembly protein 1 isoform 5", "refseq_ac": "NP_861537", "gene_names_uniprotkb": "Deup1; Ccdc67", "gene_names_refseq": "4933401K09Rik; Ccdc67; Deup1", "protein_names_uniprotkb": "Deuterosome assembly protein 1; Coiled-coil domain-containing protein 67", "protein_names_refseq": "coiled-coil domain containing 67; coiled-coil domain-containing protein 67; deuterosomal protein 1; deuterosome assembly protein 1 isoform 5; deuterosome protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234964)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12783626;21750661;24240477;38052490", "class_list": "", "function": "Deup1 Expression Interferes with Multiciliated Differentiation., [RefSeq, PubMed]; Deup1 governs deuterosome assembly to mediate large-scale de novo centriole biogenesis., [RefSeq, PubMed]; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QL16;Q4VA46", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005814 centriole;GO:0098536 deuterosome", "go_biological_process": "GO:1903251 multi-ciliated epithelial cell differentiation;GO:0030030 cell projection organization;GO:0007099 centriole replication;GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7M6Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCE9-1", "uniprot_id": "E4F1_MOUSE", "mass": 84296.0, "length": 783, "protein_name": "Transcription factor E4F1", "gene_name": "E4f1", "organism": "Mouse", "refseq_name": "transcription factor E4F1 isoform 1", "refseq_ac": "NP_001288713", "gene_names_uniprotkb": "E4f1", "gene_names_refseq": "E4f1; p120E4F; phi-AP3", "protein_names_uniprotkb": "Transcription factor E4F1; 2.3.2.27; E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; Transcription factor phi AP3; p120E4F", "protein_names_refseq": "RING-type E3 ubiquitin transferase E4F1; putative E3 ubiquitin-protein ligase E4F1; transcription factor E4F1 isoform 1; transcription factor E4F1; transcription factor phi AP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:13560)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10644996;10869426;15226446;17557114;21750661;27621431;27621446;31219806;34857760;8262041;9530632", "class_list": "", "function": "May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; These data identify E4F1 as a master regulator of the PDC., [RefSeq, PubMed]; These data reveal a central role for Dlat in the metabolic program regulated by E4F1 in basal keratinocytes., [RefSeq, PubMed]; This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05BH7;Q3UNJ9;Q62065;Q6IR08;Q6PGI1;Q9QY56", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CCE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68SA9-1", "uniprot_id": "ATS7_MOUSE", "mass": 182313.0, "length": 1657, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "gene_name": "Adamts7", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 4 preproprotein", "refseq_ac": "NP_001313280", "gene_names_uniprotkb": "Adamts7", "gene_names_refseq": "ADAM-TS7; ADAMTS7B; Adamts7", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 7; 3.4.24.-; ADAM-TS 7; ADAM-TS7; ADAMTS-7", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 4 preproprotein; COMPase; a disintegrin and metalloproteinase with thrombospondin motifs 7; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:108153); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15192113;19487464;21750661;23928557;35503474;36662289;36735376;37675562", "class_list": "", "function": "ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1., [RefSeq, PubMed]; ADAMTS-7 and TNF-alpha form a positive feedback loop in the regulation of cartilage degradation and osteoarthritis progression., [RefSeq, PubMed]; ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice., [RefSeq, PubMed]; ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses., [RefSeq, PubMed]; ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries., [RefSeq, PubMed]; ADAMTS7B has a domain organization with a total of eight thrombospondin type 1 repeats in its ancillary domain. Of these, seven are arranged in two distinct clusters that are separated by a mucin domain, [RefSeq, PubMed]; Findings demonstrate that ADAMTS-7, a direct target of PTHrP signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP chondrogenic growth factor., [RefSeq, PubMed]; Metalloprotease (PubMed:15192113). Was previously shown to degrade COMP (By similarity). However, a later study found no activity against COMP (By similarity)., [UniProtKB, PubMed, UniProtKB]; Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 2, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B2RUI8;E9QMY0", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0071773 cellular response to BMP stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q68SA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IQY5-1", "uniprot_id": "CEP70_MOUSE", "mass": 71065.0, "length": 616, "protein_name": "Centrosomal protein of 70 kDa", "gene_name": "Cep70", "organism": "Mouse", "refseq_name": "centrosomal protein of 70 kDa isoform 1", "refseq_ac": "NP_076362", "gene_names_uniprotkb": "Cep70", "gene_names_refseq": "6720484E09Rik; Bite; C030018L16Rik; Cep70", "protein_names_uniprotkb": "Centrosomal protein of 70 kDa; Cep70", "protein_names_refseq": "centrosomal protein of 70 kDa isoform 1; centrosomal protein of 70 kDa; p10-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68121); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21750661;22437770;25428506;30084848;30779550", "class_list": "", "function": "Cep70 is important for Cdc42 and Rac1 activation to promote angiogenesis., [RefSeq, PubMed]; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0L8;Q9CRL9;Q9CTS4;Q9JIC1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0006915 apoptotic process;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0060271 cilium assembly;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IQY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0W1-1", "uniprot_id": "ANMY1_MOUSE", "mass": 101999.0, "length": 906, "protein_name": "Ankyrin repeat and MYND domain-containing protein 1", "gene_name": "Ankmy1", "organism": "Mouse", "refseq_name": "ankyrin repeat and MYND domain-containing protein 1 isoform 1", "refseq_ac": "NP_766438", "gene_names_uniprotkb": "Ankmy1", "gene_names_refseq": "4930483I10Rik; Ankmy1; ZMYND13", "protein_names_uniprotkb": "Ankyrin repeat and MYND domain-containing protein 1", "protein_names_refseq": "ankyrin repeat and MYND domain-containing protein 1 isoform 1; ankyrin repeat and MYND domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241158)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IJ76", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C0W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V096-1", "uniprot_id": "ANR42_MOUSE", "mass": 58533.0, "length": 527, "protein_name": "Ankyrin repeat domain-containing protein 42", "gene_name": "Ankrd42", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 42 isoform 1", "refseq_ac": "NP_082941", "gene_names_uniprotkb": "Ankrd42", "gene_names_refseq": "4931426M20; 4933417L02Rik; Ankrd42; Ikbn", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 42", "protein_names_refseq": "ankyrin repeat domain-containing protein 42 isoform 1; ankyrin repeat domain-containing protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:73845)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20547855;21750661", "class_list": "", "function": "IkappaBeta regulates the NF-kappaB-mediated transcription of a wide variety of proinflammatory genes, playing a crucial role in the regulation of innate immune responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX55;Q8BZT3;Q8C0T6;Q8C0X5", "ec_number_list": "", "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:1900017 positive regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35639-1", "uniprot_id": "ANXA3_MOUSE", "mass": 36384.0, "length": 323, "protein_name": "Annexin A3", "gene_name": "Anxa3", "organism": "Mouse", "refseq_name": "annexin A3 isoform 1", "refseq_ac": "NP_038498", "gene_names_uniprotkb": "Anxa3; Anx3", "gene_names_refseq": "Anx3; Anxa3", "protein_names_uniprotkb": "Annexin A3; 35-alpha calcimedin; Annexin III; Annexin-3; Lipocortin III; PAP-III; Placental anticoagulant protein III", "protein_names_refseq": "35-alpha calcimedin; PAP-III; annexin A3 isoform 1; annexin III; annexin-3; lipocortin III; placental anticoagulant protein III", "tax_id": 10090, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:11745)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "18250455;21750661;23806337;31219806;32569086;34428180;37030499;37453647;37507081;37828378;38310670;9511742", "class_list": "", "function": "ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury., [RefSeq, PubMed]; Annexin A3 accelerates osteoclast differentiation by promoting the level of RANK and TRAF6., [RefSeq, PubMed]; Inhibitor of phospholipase A2, also possesses anti-coagulant properties., [UniProtKB]; Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1alpha/vascular endothelial growth factor signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBI0", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0019834 phospholipase A2 inhibitor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0043312 neutrophil degranulation;GO:0006909 phagocytosis;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35639-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TJM4-1", "uniprot_id": "CENPT_MOUSE", "mass": 56242.0, "length": 515, "protein_name": "Centromere protein T", "gene_name": "Cenpt", "organism": "Mouse", "refseq_name": "centromere protein T", "refseq_ac": "NP_796124", "gene_names_uniprotkb": "Cenpt", "gene_names_refseq": "Cenpt; G630055P03Rik", "protein_names_uniprotkb": "Centromere protein T; CENP-T", "protein_names_refseq": "CENP-T; centromere protein T", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569)", "pathway": " (mmu:320394); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "21750661;31964702", "class_list": "", "function": "CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPY6;Q3UPD2;Q8BTH0;Q8BTP2;Q8R5E9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TJM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQ08-1", "uniprot_id": "CNOT1_MOUSE", "mass": 266808.0, "length": 2375, "protein_name": "CCR4-NOT transcription complex subunit 1", "gene_name": "Cnot1", "organism": "Mouse", "refseq_name": "CCR4-NOT transcription complex subunit 1 isoform 2", "refseq_ac": "NP_835179", "gene_names_uniprotkb": "Cnot1; Kiaa1007", "gene_names_refseq": "6030411K04Rik; Cnot1; D830048B13", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 1 isoform 2; CCR4-associated factor 1", "tax_id": 10090, "disease": "Vissers-Bodmer syndrome (Disease Ontology:DOID:0081397); holoprosencephaly 12 (Disease Ontology:DOID:0081398); heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:234594); (R-MMU-429947); (R-MMU-6804115)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;20133598;21750661;22367759;22517741;22645316;22872234;25428506;25605945;30059200;31006510;31006513;31219806;32782141;32848054;32905781;34210974;34428180;34678516;34733855;35510877;35820727;35822049;36852467;38897566;39627609;40021952;40885482;40997131", "class_list": "", "function": "CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner., [RefSeq, PubMed]; Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression., [RefSeq, PubMed]; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:34733855). Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. Plays a role in rapid sperm motility via mediating timely mRNA turnover (PubMed:34733855)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "B2RY28;Q3UPB7;Q8BSB4;Q8BXB2;Q8C0H2;Q8K3D8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0030331 nuclear estrogen receptor binding;GO:0042974 nuclear retinoic acid receptor binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001829 trophectodermal cell differentiation;GO:0017148 negative regulation of translation;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q6ZQ08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UPP8-1", "uniprot_id": "CEP63_MOUSE", "mass": 80449.0, "length": 700, "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "Cep63", "organism": "Mouse", "refseq_name": "centrosomal protein of 63 kDa isoform 5", "refseq_ac": "NP_001394630", "gene_names_uniprotkb": "Cep63; D9Mgc48e", "gene_names_refseq": "4921501M07; AL450317.13gm1; CD20R; Cep63; D9Mgc41; D9Mgc48e; ET2", "protein_names_uniprotkb": "Centrosomal protein of 63 kDa; Cep63", "protein_names_refseq": "centrosomal protein of 63 kDa isoform 5; centrosomal protein of 63 kDa; centrosome protein Cep63", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Seckel syndrome 6 (Disease Ontology:DOID:0070006)", "pathway": " (mmu:28135); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "21750661;21983783;23936128;24240477;27974163;31219806;31252033;34428180;35820727;36210013", "class_list": "", "function": "Both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation. Publication Status: Online-Only, [RefSeq, PubMed]; Cep63 regulates mother-centriole-dependent centriole duplication., [RefSeq, PubMed]; In brain development, Wdr62 and Aspm localize to the proximal end of the mother centriole and interact physically, with Wdr62 required for Aspm localization, and both proteins, as well as microcephaly protein Cep63, required to localize CENPJ/CPAP/Sas-4, a final common target., [RefSeq, PubMed]; Required for normal spindle assembly (PubMed:24240477). Plays a key role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (By similarity). Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response (By similarity). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]; This study shows that IL-20-receptor signaling delimits IL-17 production in psoriatic inflammation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZM0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0045087 innate immune response;GO:0051301 cell division;GO:0050821 protein stabilization;GO:0042770 signal transduction in response to DNA damage;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UPP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN33-1", "uniprot_id": "CELF6_MOUSE", "mass": 48206.0, "length": 460, "protein_name": "CUGBP Elav-like family member 6", "gene_name": "Celf6", "organism": "Mouse", "refseq_name": "CUGBP Elav-like family member 6 isoform 2", "refseq_ac": "NP_001298021", "gene_names_uniprotkb": "Celf6; Brunol6", "gene_names_refseq": "6330569O16Rik; Brunol6; Celf6", "protein_names_uniprotkb": "CUGBP Elav-like family member 6; Bruno-like protein 6; CELF-6; CUG-BP- and ETR-3-like factor 6; RNA-binding protein BRUNOL-6", "protein_names_refseq": "CUG-BP- and ETR-3-like factor 6; CUGBP Elav-like family member 6 isoform 2; RNA-binding protein BRUNOL-6; bruno-like 6, RNA binding protein; bruno-like protein 6", "tax_id": 10090, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:76183)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25682262;31215739;33357440", "class_list": "", "function": "CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements., [RefSeq, PubMed]; Celf6 mutant mice exhibited impaired conditioned learning to both reward and aversive stimuli., [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA (By similarity)., [UniProtKB]; Results suggest that disruption of CUG-BP, Elav-like factor 6 expression in hypothalamic nuclei may impact a variety of behaviors downstream of neuropeptide activity, while disruption in neuromodulatory transmitter expressing areas such as the ventral tegmental area, substantia nigra, raphe nuclei and locus coeruleus may have far-reaching influences on overall brain activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ35", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0071625 vocalization behavior;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0099153 synaptic transmission, serotonergic;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TN33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ05-1", "uniprot_id": "AT7L1_MOUSE", "mass": 16186.0, "length": 146, "protein_name": "Ataxin-7-like protein 1", "gene_name": "Atxn7l1", "organism": "Mouse", "refseq_name": "ataxin-7-like protein 1 isoform 2", "refseq_ac": "NP_082415", "gene_names_uniprotkb": "Atxn7l1; Atxn7l4", "gene_names_refseq": "2810423G08Rik; Atxn7l1; Atxn7l4", "protein_names_uniprotkb": "Ataxin-7-like protein 1; Ataxin-7-like protein 4", "protein_names_refseq": "ataxin 7-like 4; ataxin-7-like protein 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:380753)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD60", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZ05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJW6-1", "uniprot_id": "ALRF2_MOUSE", "mass": 23730.0, "length": 218, "protein_name": "Aly/REF export factor 2", "gene_name": "Alyref2", "organism": "Mouse", "refseq_name": "aly/REF export factor 2", "refseq_ac": "NP_062357", "gene_names_uniprotkb": "Alyref2; Ref2; Refbp2", "gene_names_refseq": "Alyref2; C130042O11Rik; REF2; Refbp2", "protein_names_uniprotkb": "Aly/REF export factor 2; Alyref; RNA and export factor-binding protein 2", "protein_names_refseq": "RNA and export factor binding protein 2-I; RNA and export factor-binding protein 2; aly/REF export factor 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:56009)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10786854;11158589;17000901;18364396;20129943;21253573;21750661;24550725;25605945;34428180", "class_list": "", "function": "Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C869", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003697 single-stranded DNA binding;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0000346 transcription export complex;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JJW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXP5-1", "uniprot_id": "PANKY_MOUSE", "mass": 41599.0, "length": 385, "protein_name": "Photoreceptor ankyrin repeat protein", "gene_name": "Ankrd33", "organism": "Mouse", "refseq_name": "photoreceptor ankyrin repeat protein isoform 1", "refseq_ac": "NP_659039", "gene_names_uniprotkb": "Ankrd33; Panky", "gene_names_refseq": "A930021G21Rik; Ankrd33; Panky-a; Panky", "protein_names_uniprotkb": "Photoreceptor ankyrin repeat protein; Ankyrin repeat domain-containing protein 33", "protein_names_refseq": "ankyrin repeat domain-containing protein 33; photoreceptor ankyrin repeat protein isoform 1; photoreceptor ankyrin repeat protein; photorecptor ankyrin repeat protein A", "tax_id": 10090, "disease": "", "pathway": " (mmu:208258)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20026326;21750661", "class_list": "", "function": "Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation., [UniProtKB, PubMed]; Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D5G1T0;Q8BXP4;Q8R1Z1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BXP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTZ5-1", "uniprot_id": "ANR46_MOUSE", "mass": 25223.0, "length": 228, "protein_name": "Ankyrin repeat domain-containing protein 46", "gene_name": "Ankrd46", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 46", "refseq_ac": "NP_780343", "gene_names_uniprotkb": "Ankrd46", "gene_names_refseq": "1110054N06Rik; Ankrd46", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 46; ANK-S; Ankyrin repeat small protein", "protein_names_refseq": "ANK-S; ankyrin repeat domain-containing protein 46; ankyrin repeat small protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68839)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;25542822", "class_list": "", "function": "MiR-451 was specifically up-regulated during the implantation period, and it may play a major role in embryo implantation by targeting Ankrd46., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZK9;Q8BV97", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLN6-1", "uniprot_id": "ADA28_MOUSE", "mass": 88671.0, "length": 793, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 28", "gene_name": "Adam28", "organism": "Mouse", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor", "refseq_ac": "NP_001041640", "gene_names_uniprotkb": "Adam28", "gene_names_refseq": "Adam28; C130072N01Rik; D430033C21Rik; Dtgn1; MDC-L; MDCL; TECADAM; eMDCII", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 28; 3.4.24.-; ADAM 28; TECADAM; Thymic epithelial cell-ADAM", "protein_names_refseq": "ADAM 28; a disintegrin and metalloprotease domain 28; a disintegrin and metalloproteinase domain 28; disintegrin 1; disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor; disintegrin and metalloproteinase domain-containing protein 28; metalloproteinase-disintegrin domain containing protein TECADAM; thymic epithelial cell-ADAM", "tax_id": 10090, "disease": "estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); breast cancer (Disease Ontology:DOID:1612); invasive ductal carcinoma (Disease Ontology:DOID:3008); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); asbestos-related lung carcinoma (Disease Ontology:DOID:7596); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13522)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10794709;11724793;11867223;21750661;28707394;30084848;36210013;36685493", "class_list": "", "function": "May play a role in organogenesis and organ-specific functions such as thymic T-cell development., [UniProtKB]; Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma. Publication Status: Online-Only, [RefSeq, PubMed]; The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1)., [RefSeq, PubMed]; The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage., [RefSeq, PubMed]; This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5D070;Q8K5D2;Q8K5D3", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JLN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81269-1", "uniprot_id": "ATF1_MOUSE", "mass": 29238.0, "length": 269, "protein_name": "Cyclic AMP-dependent transcription factor ATF-1", "gene_name": "Atf1", "organism": "Mouse", "refseq_name": "cyclic AMP-dependent transcription factor ATF-1", "refseq_ac": "NP_031523", "gene_names_uniprotkb": "Atf1", "gene_names_refseq": "Atf1", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-1; Activating transcription factor 1; TCR-ATF1; cAMP-dependent transcription factor ATF-1", "protein_names_refseq": "TCR-ATF1; cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:11908); (R-MMU-199920)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11909979;1531847;18690222;19776387;21098035;21750661;31219806;32611235;32782141;34007999;35568813;36852467;40997131", "class_list": "", "function": "ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption. Publication Status: Online-Only, [RefSeq, PubMed]; Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity)., [UniProtKB]; Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1., [RefSeq, PubMed]; Testicular localization of activating transcription factor 1 and its potential function during spermatogenesisdagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:1990590 ATF1-ATF4 transcription factor complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010976 positive regulation of neuron projection development;GO:0014074 response to purine-containing compound;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P81269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHK4-1", "uniprot_id": "KAT5_MOUSE", "mass": 58598.0, "length": 513, "protein_name": "Histone acetyltransferase KAT5", "gene_name": "Kat5", "organism": "Mouse", "refseq_name": "histone acetyltransferase KAT5 isoform 2", "refseq_ac": "NP_001186176", "gene_names_uniprotkb": "Kat5; Htatip; Tip60", "gene_names_refseq": "CPLA2; Htatip1; Htatip; Kat5; PLIP; Tip55; Tip60", "protein_names_uniprotkb": "Histone acetyltransferase KAT5; 2.3.1.-; 2.3.1.48; 60 kDa Tat-interactive protein; Histone acetyltransferase HTATIP; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tip60", "protein_names_refseq": "60 kDa Tat-interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; Tat-interactive protein-60; histone acetyltransferase HTATIP; histone acetyltransferase KAT5 isoform 2; histone acetyltransferase KAT5; lysine acetyltransferase 5; protein 2-hydroxyisobutyryltransferase KAT5; protein acetyltransferase KAT5; protein crotonyltransferase KAT5; protein lactyltransferase KAT5", "tax_id": 10090, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:81601); (R-MMU-2559586); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693548); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473); (R-MMU-9018519)", "pathway_count": 15, "publication_count": 24, "publication_id_list": "12036595;12801643;14687547;16597624;17728759;19696312;21183079;21750661;22539723;24835996;26291311;28694333;29449840;29765047;30297459;30297694;31294688;32542325;32817552;33076429;34428180;34608293;37024457;39422647", "class_list": "", "function": "Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:28694333, PubMed:30297459, PubMed:32542325). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (By similarity). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17728759). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:30297459). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (PubMed:32542325). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:22539723, PubMed:24835996, PubMed:31294688). Directly acetylates and activates ATM (By similarity). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (By similarity). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (By similarity). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (By similarity). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (PubMed:31294688). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (By similarity). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:29765047). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (By similarity). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (By similarity). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (By similarity). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (By similarity). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (By similarity). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (By similarity). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (By similarity). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RORa-dependent recruitment to Pcp2, Pcp4 and Slc1a6 promoters in cerebellar Purkinje cells., [RefSeq, PubMed]; The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development. Publication Status: Online-Only, [RefSeq, PubMed]; Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A494B9U8;A1L394;Q3YFI9;Q8CGZ3;Q8CGZ4;Q8VIH0", "ec_number_list": "2.3.1.48;2.3.1.-;3.1.3.48;2.7.11.1;5.6.2.1;2.3.2.27;5.6.2.4;4.2.99.18;6.5.1.1;3.4.19.-;2.7.7.7;3.1.11.-;2.3.2.23;2.3.2.-;3.6.-.-;2.7.11.22;3.1.3.16;3.6.4.-;2.3.2.26;5.6.2.3;3.1.-.-;3.6.4.13;2.1.1.357;1.14.11.69;1.14.11.66;2.7.11.24;3.1.22.-;2.3.1.259;2.3.1.57;2.1.1.319;2.3.1.80;4.2.1.-;3.1.11.2", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0140065 peptide butyryltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:1901985 positive regulation of protein acetylation;GO:0032703 negative regulation of interleukin-2 production", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8CHK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KFM7-1", "uniprot_id": "CHD6_MOUSE", "mass": 305397.0, "length": 2711, "protein_name": "ATP-dependent chromatin remodeler CHD6", "gene_name": "Chd6", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD6", "refseq_ac": "NP_775544", "gene_names_uniprotkb": "Chd6; Kiaa1335", "gene_names_refseq": "5430439G14Rik; 6330406J24Rik; CHD-6; Chd6", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD6; 3.6.4.-; CHD-6; Chromo domain-containing protein 6", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD6; ATP-dependent helicase CHD6; chromo domain-containing protein 6", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:71389)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17027977;20111866;21183079;21750661;25428506;30084848;30779550;31219806;34428180;36852467", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2., [UniProtKB, UniProtKB]; CHD6 colocalizes with both hypo- and hyper-phosphorlylated forms of RNA polymerase II. CHD6 was found to be present at sites of mRNA synthesis and to be part of a high molecular weight complex., [RefSeq, PubMed]; The genomic location, expression pattern, and ataxic phenotype of Chd6 Exon 12 -/- mice indicate that mutations within CHD6 may be responsible for ataxias., [RefSeq, PubMed]; This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EKA7;Q3UQS6;Q80TE9", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045454 cell redox homeostasis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A3KFM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYU2-1", "uniprot_id": "AT135_MOUSE", "mass": 136760.0, "length": 1216, "protein_name": "Probable cation-transporting ATPase 13A5", "gene_name": "Atp13a5", "organism": "Mouse", "refseq_name": "probable cation-transporting ATPase 13A5 isoform 2", "refseq_ac": "NP_001271304", "gene_names_uniprotkb": "Atp13a5", "gene_names_refseq": "Atp13a5; C630015F21Rik", "protein_names_uniprotkb": "Probable cation-transporting ATPase 13A5; 7.2.2.-; P5-ATPase isoform 5", "protein_names_refseq": "P5-ATPase; probable cation-transporting ATPase 13A5 isoform 2; probable cation-transporting ATPase 13A5", "tax_id": 10090, "disease": "Kufor-Rakeb syndrome (Disease Ontology:DOID:0060556); juvenile-onset Parkinson's disease (Disease Ontology:DOID:0060893); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:268878); (R-MMU-936837)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15381061;21750661;30059200;30084848;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q14BM0;Q8BUP1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:1902047 polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3TYU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CTG6-1", "uniprot_id": "AT132_MOUSE", "mass": 126443.0, "length": 1169, "protein_name": "Polyamine-transporting ATPase 13A2", "gene_name": "Atp13a2", "organism": "Mouse", "refseq_name": "polyamine-transporting ATPase 13A2 isoform 1", "refseq_ac": "NP_083373", "gene_names_uniprotkb": "Atp13a2", "gene_names_refseq": "1110012E06Rik; Atp13a2", "protein_names_uniprotkb": "Polyamine-transporting ATPase 13A2; 7.6.2.-", "protein_names_refseq": "polyamine-transporting ATPase 13A2 isoform 1; polyamine-transporting ATPase 13A2; probable cation-transporting ATPase 13A2", "tax_id": 10090, "disease": "Kufor-Rakeb syndrome (Disease Ontology:DOID:0060556); juvenile-onset Parkinson's disease (Disease Ontology:DOID:0060893); hereditary spastic paraplegia 78 (Disease Ontology:DOID:0112348); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:74772); (R-MMU-936837)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "20485683;21750661;22186024;22198378;27278822;30538141;31219806;34428180;34536552;35887392;37243374", "class_list": "", "function": "ATP13A2 Declines Zinc-Induced Accumulation of alpha-Synuclein in a Parkinson's Disease Model. Publication Status: Online-Only, [RefSeq, PubMed]; ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB-PGD axis., [RefSeq, PubMed]; ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (By similarity). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (By similarity). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (By similarity). Contributes to cellular zinc homeostasis (By similarity). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (By similarity). Required for proper lysosomal and mitochondrial maintenance (By similarity). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (By similarity). Plays a role in lipid homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis., [UniProtKB, UniProtKB, UniProtKB]; Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological alpha-synuclein spread in the prodromal preformed fibrils model in young mice., [RefSeq, PubMed]; Study reveals a number of intriguing neuronal phenotypes due to the loss- or gain-of-function of ATP13A2 that support a role for this protein in regulating intracellular cation homeostasis and neuronal integrity, [RefSeq, PubMed]; This study showed that ATP13A2 regulates mitochondrial bioenergetics through macroautophagy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AA78;Q8CG98", "ec_number_list": "7.2.2.-;7.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0043025 neuronal cell body;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:1903710 spermine transmembrane transport;GO:0010628 positive regulation of gene expression;GO:0055088 lipid homeostasis;GO:0006874 intracellular calcium ion homeostasis;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CTG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17426-1", "uniprot_id": "AP2A1_MOUSE", "mass": 107664.0, "length": 977, "protein_name": "AP-2 complex subunit alpha-1", "gene_name": "Ap2a1", "organism": "Mouse", "refseq_name": "AP-2 complex subunit alpha-1 isoform b", "refseq_ac": "NP_001070732", "gene_names_uniprotkb": "Ap2a1; Adtaa; Clapa1", "gene_names_refseq": "Adtaa; Ap2a1", "protein_names_uniprotkb": "AP-2 complex subunit alpha-1; 100 kDa coated vesicle protein A; Adaptor protein complex AP-2 subunit alpha-1; Adaptor-related protein complex 2 subunit alpha-1; Alpha-adaptin A; Alpha1-adaptin; Clathrin assembly protein complex 2 alpha-A large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit", "protein_names_refseq": "100 kDa coated vesicle protein A; AP-2 complex subunit alpha-1 isoform b; AP-2 complex subunit alpha-1; adapter-related protein complex 2 alpha-1 subunit; adapter-related protein complex 2 subunit alpha-1; adaptor protein complex AP-2 subunit alpha-1; adaptor protein complex AP-2, alpha 1 subunit; adaptor-related protein complex 2 subunit alpha-1; adaptor-related protein complex AP-2, alpha 1 subunit; alpha-adaptin A; alpha1-adaptin; clathrin assembly protein complex 2 alpha-A large chain; plasma membrane adaptor HA2/AP2 adaptin alpha A subunit", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:11771); (R-MMU-177504); (R-MMU-2132295); (R-MMU-416993); (R-MMU-437239); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8866427); (R-MMU-8964038)", "pathway_count": 11, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;14745134;15473838;16075062;17242355;17626015;18625303;21183079;21750661;21952136;22872234;23676497;25428506;25605945;2564002;29262337;30084848;30779550;31599954;33300544;34428180;7559550;7593326", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0044877 protein-containing complex binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016323 basolateral plasma membrane;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:0010976 positive regulation of neuron projection development;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P17426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AS55-1", "uniprot_id": "ANR16_MOUSE", "mass": 39776.0, "length": 361, "protein_name": "Ankyrin repeat domain-containing protein 16", "gene_name": "Ankrd16", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 16 isoform 1", "refseq_ac": "NP_796242", "gene_names_uniprotkb": "Ankrd16", "gene_names_refseq": "2810455F06Rik; Ankrd16; D430029B21Rik", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 16", "protein_names_refseq": "ankyrin repeat domain-containing protein 16 isoform 1; ankyrin repeat domain-containing protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:320816)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29769718", "class_list": "", "function": "Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity (PubMed:29769718). Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides (PubMed:29769718)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results identify an amino-acid-accepting co-regulator of tRNA synthetase editing, ANKRD16, as a new layer of the machinery that is essential to the prevention of severe pathologies that arise from defects in editing Erratum:[Nature. 2018 Aug;560(7720):E35. doi: 10.1038/s41586-018-0271-3. PMID: 29925958], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH84", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AS55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q743-1", "uniprot_id": "CF251_MOUSE", "mass": 148608.0, "length": 1299, "protein_name": "Cilia- and flagella-associated protein 251", "gene_name": "Cfap251", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 251", "refseq_ac": "NP_001357769", "gene_names_uniprotkb": "Cfap251; Wdr66", "gene_names_refseq": "4930415N18Rik; 4933428F06Rik; 5031404N07; Cfap251; Wdr66", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 251; WD repeat-containing protein 66", "protein_names_refseq": "WD repeat domain 66; WD repeat-containing protein 66; cilia- and flagella-associated protein 251", "tax_id": 10090, "disease": "spermatogenic failure 33 (Disease Ontology:DOID:0111915)", "pathway": " (mmu:269701)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17971504;21750661;34418053", "class_list": "", "function": "Involved in spermatozoa motility (By similarity). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Wdr66 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMR0;Q9D3X6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097225 sperm midpiece;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "E9Q743-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35153-1", "uniprot_id": "BET1L_MOUSE", "mass": 12428.0, "length": 111, "protein_name": "BET1-like protein", "gene_name": "Bet1l", "organism": "Mouse", "refseq_name": "BET1-like protein", "refseq_ac": "NP_061212", "gene_names_uniprotkb": "Bet1l; Gs15", "gene_names_refseq": "2610021K23Rik; Bet1l; Gs15", "protein_names_uniprotkb": "BET1-like protein; GOS-15; GS15; Golgi SNARE with a size of 15 kDa; Vesicle transport protein GOS15", "protein_names_refseq": "BET1-like protein; GOS-15; blocked early in transport 1 homolog-like; golgi SNARE with a size of 15 kDa; golgi SNARE, 15 kD; soluble N-ethylmaleimide-sensitive factor attachment protein (SNARE) 15; vesicle transport protein GOS15", "tax_id": 10090, "disease": "uterine fibroid (Disease Ontology:DOID:13223); endometrial adenocarcinoma (Disease Ontology:DOID:2870)", "pathway": " (mmu:54399); (R-MMU-6807878); (R-MMU-6811438)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16195346;21750661;9242691", "class_list": "", "function": "Two amino acidubstitutions do not regulate secretion by affecting the property of SNARE complex itself., [RefSeq, PubMed]; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0E4", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:2000156 regulation of retrograde vesicle-mediated transport, Golgi to ER", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHG5-1", "uniprot_id": "AREL1_MOUSE", "mass": 94199.0, "length": 823, "protein_name": "Apoptosis-resistant E3 ubiquitin protein ligase 1", "gene_name": "Arel1", "organism": "Mouse", "refseq_name": "apoptosis-resistant E3 ubiquitin protein ligase 1", "refseq_ac": "NP_835166", "gene_names_uniprotkb": "Arel1; 1110018G07Rik; Kiaa0317", "gene_names_refseq": "1110018G07Rik; Arel1", "protein_names_uniprotkb": "Apoptosis-resistant E3 ubiquitin protein ligase 1; 2.3.2.26; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1", "protein_names_refseq": "apoptosis-resistant E3 ubiquitin protein ligase 1; apoptosis-resistant HECT-type E3 ubiquitin transferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68497); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;23479728;25605945;27162139;30084848;31578312;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (By similarity). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (By similarity). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312)., [UniProtKB, UniProtKB, PubMed]; KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; New protein isoform encoded by KIAA0317, termed fibrosis-inducing E3 ligase 1 (FIEL1), which potently stimulates the TGFbeta signaling pathway through the site-specific ubiquitination of PIAS4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9Q1;Q80YC4;Q8C5W5", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050727 regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CHG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D516-1", "uniprot_id": "YJU2B_MOUSE", "mass": 43880.0, "length": 385, "protein_name": "Probable splicing factor YJU2B", "gene_name": "Yju2b", "organism": "Mouse", "refseq_name": "probable splicing factor YJU2B isoform 2", "refseq_ac": "NP_001281210", "gene_names_uniprotkb": "Yju2b; Ccdc130", "gene_names_refseq": "4930527D15Rik; Ccdc130; Yju2b", "protein_names_uniprotkb": "Probable splicing factor YJU2B; Coiled-coil domain-containing protein 130", "protein_names_refseq": "coiled-coil domain containing 130; coiled-coil domain-containing protein 130; probable splicing factor YJU2B isoform 2; probable splicing factor YJU2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:67736)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCB4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0071014 post-mRNA release spliceosomal complex;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0009615 response to virus;GO:0045292 mRNA cis splicing, via spliceosome;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98199-1", "uniprot_id": "AT8B2_MOUSE", "mass": 136968.0, "length": 1209, "protein_name": "Phospholipid-transporting ATPase ID", "gene_name": "Atp8b2", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase ID isoform 1", "refseq_ac": "NP_001355579", "gene_names_uniprotkb": "Atp8b2", "gene_names_refseq": "Atp8b2; Id", "protein_names_uniprotkb": "Phospholipid-transporting ATPase ID; 7.6.2.1; ATPase class I type 8B member 2; P4-ATPase flippase complex alpha subunit ATP8B2", "protein_names_refseq": "Atpase 8B2, p type; P4-ATPase flippase complex alpha subunit ATP8B2; phospholipid-transporting ATPase ID isoform 1; probable phospholipid-transporting ATPase ID", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:54667); (R-MMU-936837)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11015572;20628604;21750661;25605945;30018401;30779550;34428180", "class_list": "", "function": "Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry., [UniProtKB, UniProtKB]; Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1;7.6.2.2", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090554 phosphatidylcholine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P98199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811I0-1", "uniprot_id": "ATPF1_MOUSE", "mass": 36355.0, "length": 324, "protein_name": "ATP synthase mitochondrial F1 complex assembly factor 1", "gene_name": "Atpaf1", "organism": "Mouse", "refseq_name": "ATP synthase mitochondrial F1 complex assembly factor 1 isoform 2", "refseq_ac": "NP_001356162", "gene_names_uniprotkb": "Atpaf1", "gene_names_refseq": "6330547J17Rik; ATP11p; ATP11; Atpaf1", "protein_names_uniprotkb": "ATP synthase mitochondrial F1 complex assembly factor 1", "protein_names_refseq": "ATP synthase mitochondrial F1 complex assembly factor 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:230649)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12965202;17438143;21750661;31219806;34375736;34428180;36210013;36288343;37507081", "class_list": "", "function": "Ca(2+)-dependent interaction of SF100A1 with Atpaf1 leads to an increased ATP content in cardiomyocytes., [RefSeq, PubMed]; Has a complex stabilizing activity in the assembly of the mitochondrial F1-F0 complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140777 protein-containing complex stabilizing activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q811I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84091-1", "uniprot_id": "AP2M1_MOUSE", "mass": 49655.0, "length": 435, "protein_name": "AP-2 complex subunit mu", "gene_name": "Ap2m1", "organism": "Mouse", "refseq_name": "AP-2 complex subunit mu isoform 1", "refseq_ac": "NP_033809", "gene_names_uniprotkb": "Ap2m1; Clapm1", "gene_names_refseq": "Ap2m1", "protein_names_uniprotkb": "AP-2 complex subunit mu; AP-2 mu chain; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; Mu2-adaptin; Plasma membrane adaptor AP-2 50 kDa protein", "protein_names_refseq": "AP-2 complex subunit mu isoform 1; AP-2 complex subunit mu; AP-2 mu chain; adapter-related protein complex 2 mu subunit; adaptor protein complex AP-2 subunit mu; adaptor protein complex AP-2, mu1; adaptor-related protein complex 2 subunit mu; adaptor-related protein complex AP-2, mu1; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; clathrin-associated AP-2; mu2-adaptin; plasma membrane adaptor AP-2 50 kDa protein", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 60 with seizures (Disease Ontology:DOID:0061050); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:11773); (R-MMU-177504); (R-MMU-190873); (R-MMU-196025); (R-MMU-2132295); (R-MMU-416993); (R-MMU-437239); (R-MMU-5099900); (R-MMU-5140745); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8866427); (R-MMU-8964038)", "pathway_count": 13, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10910768;14530274;14745134;15473838;16227583;16479539;16707488;21183079;21750661;23676497;26495903;28011936;31219806;31599954;33300544;34428180;36210013;37453647;37507081;37828378;7569928;9573360", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (By similarity). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (By similarity). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (By similarity). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P20172;P53679", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding;GO:0005048 signal sequence binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006886 intracellular protein transport;GO:0031623 receptor internalization;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P84091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFX2-1", "uniprot_id": "ANTR2_MOUSE", "mass": 53184.0, "length": 487, "protein_name": "Anthrax toxin receptor 2", "gene_name": "Antxr2", "organism": "Mouse", "refseq_name": "anthrax toxin receptor 2 precursor", "refseq_ac": "NP_598499", "gene_names_uniprotkb": "Antxr2", "gene_names_refseq": "2310046B19Rik; Antxr2; CMG-2; CMG2; cI-35", "protein_names_uniprotkb": "Anthrax toxin receptor 2", "protein_names_refseq": "anthrax toxin receptor 2 precursor", "tax_id": 10090, "disease": "fibroma (Disease Ontology:DOID:0050871); hyaline fibromatosis syndrome (Disease Ontology:DOID:0111669); anthrax disease (Disease Ontology:DOID:7427)", "pathway": " (mmu:71914)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16141341;21750661;26495903;28011936;31219806;34428180;35212873;37828378", "class_list": "", "function": "Because protective antigen binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway, [RefSeq, PubMed]; Capillary morphogenesis gene 2 (CMG2) mediates growth factor-induced angiogenesis by regulating endothelial cell chemotaxis., [RefSeq, PubMed]; Necessary for cellular interactions with laminin and the extracellular matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99L17", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007338 single fertilization;GO:0030199 collagen fibril organization;GO:0060065 uterus development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6DFX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V80-1", "uniprot_id": "APOF_MOUSE", "mass": 34359.0, "length": 315, "protein_name": "Apolipoprotein F", "gene_name": "Apof", "organism": "Mouse", "refseq_name": "apolipoprotein F precursor", "refseq_ac": "NP_598758", "gene_names_uniprotkb": "Apof; Lvif", "gene_names_refseq": "Apof; LVIF", "protein_names_uniprotkb": "Apolipoprotein F; Apo-F; LVIF; Leukemia virus-inactivating factor", "protein_names_refseq": "apolipoprotein F precursor; leukemia virus-inactivating factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:103161)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11836406;21750661;26495903;38540406", "class_list": "", "function": "Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII., [UniProtKB, UniProtKB]; Unveiling the Impact of ApoF Deficiency on Liver and Lipid Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91V80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569N2-1", "uniprot_id": "ANR37_MOUSE", "mass": 17262.0, "length": 159, "protein_name": "Ankyrin repeat domain-containing protein 37", "gene_name": "Ankrd37", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 37 isoform a", "refseq_ac": "NP_001034651", "gene_names_uniprotkb": "Ankrd37", "gene_names_refseq": "Ankrd37", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 37", "protein_names_refseq": "ankyrin repeat domain-containing protein 37 isoform a; ankyrin repeat domain-containing protein 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:654824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21723927;21750661", "class_list": "", "function": "Fem1b is a binding partner of Ankrd37, and their interaction resulted in Ankrd37 degradation through the ubiquitin-mediated proteolysis pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHS0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q569N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00623-1", "uniprot_id": "APOA1_MOUSE", "mass": 30616.0, "length": 264, "protein_name": "Apolipoprotein A-I", "gene_name": "Apoa1", "organism": "Mouse", "refseq_name": "apolipoprotein A-I preproprotein", "refseq_ac": "NP_033822", "gene_names_uniprotkb": "Apoa1", "gene_names_refseq": "Alp-1; Apoa-1; Apoa1; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2; apo-AI; apoA-I", "protein_names_uniprotkb": "Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1", "protein_names_refseq": "apolipoprotein A-I preproprotein; apolipoprotein A1", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary hypoalphalipoproteinemia 2 (Disease Ontology:DOID:0080958); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrotic syndrome (Disease Ontology:DOID:1184); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypolipoproteinemia (Disease Ontology:DOID:1387); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); coronary artery disease (Disease Ontology:DOID:3393); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11806); (R-MMU-114608); (R-MMU-1369062); (R-MMU-2168880); (R-MMU-3000471); (R-MMU-3000480); (R-MMU-381426); (R-MMU-8957275); (R-MMU-8963888); (R-MMU-8963896); (R-MMU-8963901); (R-MMU-8964011); (R-MMU-8964058); (R-MMU-9707616); (R-MMU-975634)", "pathway_count": 15, "publication_count": 11, "publication_id_list": "1478650;1596360;16876491;21750661;23386199;30084848;30779550;34428180;36288343;37507081;39627609", "class_list": "", "function": "Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility., [UniProtKB]; This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08855;O09042;Q8BPD5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0019899 enzyme binding;GO:0034191 apolipoprotein A-I receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0009986 cell surface;GO:0034363 intermediate-density lipoprotein particle", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q00623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35936-1", "uniprot_id": "ALOX8_MOUSE", "mass": 76230.0, "length": 677, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX8", "gene_name": "Alox8", "organism": "Mouse", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX8", "refseq_ac": "NP_033791", "gene_names_uniprotkb": "Alox8; Alox15b", "gene_names_refseq": "15-LOX-2; 15-LOX-B; 8-LOX; 8S-LOX; Alox15b; Alox8", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX8; 1.13.11.-; 1.13.11.58; 15-LOX-2; 15-LOX-B; 15-lipoxygenase 2; 8-LOX; 8S-LOX; Arachidonate 15-lipoxygenase B; Arachidonate 8S-lipoxygenase; Linoleate 9S-lipoxygenase ALOX8", "protein_names_refseq": "15-lipoxygenase 2; 8S-lipoxygenase; arachidonate 15-lipoxygenase B; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate 8S-lipoxygenase; linoleate 9S-lipoxygenase ALOX8; polyunsaturated fatty acid lipoxygenase ALOX8", "tax_id": 10090, "disease": "", "pathway": " (mmu:11688); (R-MMU-2142770)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10625675;10965849;11368335;15558016;16112079;16143298;21750661;27435673;31362020;37446212;9305900;9518531", "class_list": "", "function": "Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models. Publication Status: Online-Only, [RefSeq, PubMed]; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:10625675, PubMed:10965849, PubMed:15558016, PubMed:16112079, PubMed:16143298, PubMed:27435673, PubMed:9305900). Catalyzes the peroxidation of arachidonate and linoleate into (8S)-HPETE and (9S)-HPODE respectively (PubMed:10625675, PubMed:10965849, PubMed:15558016, PubMed:16112079, PubMed:16143298, PubMed:27435673, PubMed:9305900). In addition to generate (8S)-HPETE from free arachidonic acid (AA), may produce other HETE isomers from phospholipid-esterified polyunsaturated fatty acids and minor products derived from (8S)-HPETE itself that may include leukotriene A4 and 8,15-diHPETE (PubMed:16112079, PubMed:16143298, PubMed:27435673). With free arachidonate as substrate, has no detectable 15S-lipoxygenase activity and only displays a 8S-lipoxygenase activity (PubMed:10625675, PubMed:10965849, PubMed:15558016, PubMed:16112079, PubMed:16143298, PubMed:9305900). However may have a 15S-lipoxygenase activity with (8S)-HPETE to produce (8S,15S)-diHPETE and when oxidizes directly arachidonic acid esterified to membrane-bound phospholipids to produce a phospholipid-esterified 15-HpETE (PubMed:16112079, PubMed:16143298, PubMed:27435673). May also catalyze (15S)-HPETE peroxidation to produce 8,15-diHPETE (PubMed:16112079). May play a role in keratinocyte differentiation through activation of the peroxisome proliferator activated receptor signaling pathway (PubMed:10965849)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Our findings, for the first time, strongly indicate that 1a may serve as a potent and promising cardioprotective agent in treatment of ischemia-reperfusion (I/R) injury, at least partially through targeting 12/15-LOX-2., [RefSeq, PubMed]; This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASX5", "ec_number_list": "1.13.11.-;1.13.11.58;1.13.11.31;1.13.11.33;1.13.11.12;1.13.11.34", "go_molecular_function": "GO:0005506 iron ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0036403 arachidonate 8(S)-lipoxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0071926 endocannabinoid signaling pathway;GO:0034440 lipid oxidation;GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16406-1", "uniprot_id": "AMPE_MOUSE", "mass": 107956.0, "length": 945, "protein_name": "Glutamyl aminopeptidase", "gene_name": "Enpep", "organism": "Mouse", "refseq_name": "glutamyl aminopeptidase", "refseq_ac": "NP_031960", "gene_names_uniprotkb": "Enpep", "gene_names_refseq": "6030431M22Rik; APA; Bp-1/6C3; Enpep; Ly-51; Ly51", "protein_names_uniprotkb": "Glutamyl aminopeptidase; 3.4.11.7; AP-A; Aminopeptidase A; BP-1/6C3 antigen; EAP", "protein_names_refseq": "AP-A; BP-1/6C3 antigen; EAP; aminopeptidase A; glutamyl aminopeptidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:13809); (R-MMU-2022377)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;1689065;21750661;30084848;31219806;33300544;33316280;33881611;34428180;37507081;39627609", "class_list": "", "function": "Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain., [RefSeq, PubMed]; Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys., [RefSeq, PubMed]; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.11.7", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0045177 apical part of cell;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0016485 protein processing;GO:0002003 angiotensin maturation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P16406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1D3-1", "uniprot_id": "AMPD1_MOUSE", "mass": 86105.0, "length": 745, "protein_name": "AMP deaminase 1", "gene_name": "Ampd1", "organism": "Mouse", "refseq_name": "AMP deaminase 1", "refseq_ac": "NP_001028475", "gene_names_uniprotkb": "Ampd1", "gene_names_refseq": "Ampd-1; Ampd1", "protein_names_uniprotkb": "AMP deaminase 1; 3.5.4.6; AMP deaminase isoform M; Myoadenylate deaminase", "protein_names_refseq": "AMP deaminase 1; adenosine monophosphate deaminase 1 (isoform M); myoadenylate deaminase", "tax_id": 10090, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); coronary artery disease (Disease Ontology:DOID:3393); lung adenocarcinoma (Disease Ontology:DOID:3910); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:229665); (R-MMU-74217)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;39927985", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VPY9", "ec_number_list": "3.5.4.6", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0006188 IMP biosynthetic process;GO:0032264 IMP salvage;GO:0033198 response to ATP;GO:0032263 GMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V1D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00688-1", "uniprot_id": "AM2A5_MOUSE", "mass": 57318.0, "length": 508, "protein_name": "Pancreatic alpha-amylase 2a5", "gene_name": "Amy2a5", "organism": "Mouse", "refseq_name": "pancreatic alpha-amylase 2a5 precursor", "refseq_ac": "NP_001036176", "gene_names_uniprotkb": "Amy2a5; Amy2a; Amy2", "gene_names_refseq": "1810008N23Rik; Amy-2; Amy2a5; Amy2; mAmy2-2", "protein_names_uniprotkb": "Pancreatic alpha-amylase 2a5; 1,4-alpha-D-glucan glucanohydrolase; 3.2.1.1; PA", "protein_names_refseq": "1,4-alpha-D-glucan glucanohydrolase; PA; amylase 2, pancreatic; amylase 2a5, pancreatic; pancreatic alpha-amylase 2a5 precursor; pancreatic alpha-amylase 2a5; pancreatic alpha-amylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043684); (mmu:100043686); (mmu:100043688); (mmu:109959); (R-MMU-189085)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "20939500;2414282;2436036;2987507;31044023;35820727;36210013;36583994;6098446;6157477;6165618;6176715;6180955", "class_list": "glycogene;glycosylhydrolase", "function": "Studies confirmed the involvement of AQP8 in alpha-amylase 2 regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBW6;Q61295;Q61296;Q64301", "ec_number_list": "3.2.1.1", "go_molecular_function": "GO:0016160 amylase activity;GO:0031404 chloride ion binding;GO:0005509 calcium ion binding;GO:0004556 alpha-amylase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016052 carbohydrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05125-1", "uniprot_id": "ANF_MOUSE", "mass": 16572.0, "length": 152, "protein_name": "Natriuretic peptides A", "gene_name": "Nppa", "organism": "Mouse", "refseq_name": "natriuretic peptides A preproprotein", "refseq_ac": "NP_032751", "gene_names_uniprotkb": "Nppa; Pnd", "gene_names_refseq": "ANP; Anf; CDD; Nppa; Pnd", "protein_names_uniprotkb": "Natriuretic peptides A; ANF 1-33; ANF 3-33; ANF 8-33; ANF; Alpha-atrial natriuretic peptide; Alpha-hANP; Atrial natriuretic factor 1-33; Atrial natriuretic factor 3-33; Atrial natriuretic factor 8-33; Atrial natriuretic factor prohormone; Atrial natriuretic factor; Atrial natriuretic peptide prohormone; Atriopeptigen; Atriopeptin III; Atriopeptin II; Atriopeptin I; CDD 95-126; CDD-ANF; CDD-ANP (95-126); CDD-ANP (99-126); CDD; Cardiodilatin; Cardionatrin; LANH; Long-acting natriuretic hormone; Pro atrial natriuretic factor 1-30; Pro atrial natriuretic factor 31-67; Pro atrial natriuretic factor 79-98; Pro atrial natriuretic factor 99-126; Pro atrial natriuretic peptide 1-30; Pro atrial natriuretic peptide 31-67; Pro atrial natriuretic peptide 79-98; Pro atrial natriuretic peptide 95-126; preproANF; preproANP; preproCDD-ANF; proANF 1-30; proANF 31-67; proANF 79-98; proANF 99-126; proANF; proANP 1-30; proANP 31-67; proANP 79-98; proANP 95-126; proANP", "protein_names_refseq": "atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; natriuretic peptide precursor type A; natriuretic peptides A preproprotein; natriuretic peptides A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); stroke (Disease Ontology:DOID:0051061); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); atrial standstill 2 (Disease Ontology:DOID:0080663); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); peritonitis (Disease Ontology:DOID:8283); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:230899); (R-MMU-5578768)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11884416;12890708;15637153;22437503;30084848;34428180;36288343;6542248;8760210", "class_list": "", "function": "Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney., [UniProtKB, UniProtKB]; Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:12890708, PubMed:22437503, PubMed:8760210). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed:12890708). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed:22437503, PubMed:8760210). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (PubMed:22437503). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips., [UniProtKB, UniProtKB]; This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FW59", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051427 hormone receptor binding;GO:0071855 neuropeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005903 brush border;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:1904681 response to 3-methylcholanthrene;GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P05125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51910-1", "uniprot_id": "APOD_MOUSE", "mass": 21530.0, "length": 189, "protein_name": "Apolipoprotein D", "gene_name": "Apod", "organism": "Mouse", "refseq_name": "apolipoprotein D precursor", "refseq_ac": "NP_001288282", "gene_names_uniprotkb": "Apod", "gene_names_refseq": "Apod", "protein_names_uniprotkb": "Apolipoprotein D; Apo-D; ApoD", "protein_names_refseq": "apolipoprotein D precursor", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); status epilepticus (Disease Ontology:DOID:1824); vasculogenic impotence (Disease Ontology:DOID:4762); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11815); (R-MMU-804914)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21632073;30899004;38868762;7637575;8666283", "class_list": "", "function": "APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts., [UniProtKB]; Apolipoprotein D facilitates rabies virus propagation by interacting with G protein and upregulating cholesterol. Publication Status: Online-Only, [RefSeq, PubMed]; The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia., [RefSeq, PubMed]; The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. Elevated levels of this gene product have been observed in multiple tissues of Niemann-Pick disease mouse models, as well as in some tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZE7", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0007420 brain development;GO:0006006 glucose metabolic process;GO:0051895 negative regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53995-1", "uniprot_id": "APC1_MOUSE", "mass": 215994.0, "length": 1944, "protein_name": "Anaphase-promoting complex subunit 1", "gene_name": "Anapc1", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 1", "refseq_ac": "NP_032595", "gene_names_uniprotkb": "Anapc1; Mcpr; Tsg24", "gene_names_refseq": "2610021O03Rik; Anapc1; Apc1; Mcpr; tsg24", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein", "protein_names_refseq": "anaphase-promoting complex subunit 1; cyclosome subunit 1; meiotic check point regulator; mitotic checkpoint regulator; testis-specific gene 24 protein", "tax_id": 10090, "disease": "Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (mmu:17222); (R-MMU-141430); (R-MMU-174048); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-176407); (R-MMU-176408); (R-MMU-176409); (R-MMU-176412); (R-MMU-179409); (R-MMU-2467813); (R-MMU-2559582); (R-MMU-68867); (R-MMU-69017); (R-MMU-983168)", "pathway_count": 17, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;23263983;26329581;31219806;34428180;40021952;7929068", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity)., [UniProtKB, UniProtKB]; EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact., [RefSeq, PubMed]; Findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ATQ4;Q8BP33;Q8C772", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0007091 metaphase/anaphase transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53995-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TZM9-1", "uniprot_id": "ALG11_MOUSE", "mass": 55270.0, "length": 492, "protein_name": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase", "gene_name": "Alg11", "organism": "Mouse", "refseq_name": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1", "refseq_ac": "NP_001230090", "gene_names_uniprotkb": "Alg11", "gene_names_refseq": "Alg11; B230397C21; Mmat-4(5)", "protein_names_uniprotkb": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; 2.4.1.131; Asparagine-linked glycosylation protein 11 homolog; Glycolipid 2-alpha-mannosyltransferase", "protein_names_refseq": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1; GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase); asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase); asparagine-linked glycosylation protein 11 homolog; defective mannosyltransferase IV(V); glycolipid 2-alpha-mannosyltransferase; mannosyltransferase IV(V)", "tax_id": 10090, "disease": "congenital disorder of glycosylation Ip (Disease Ontology:DOID:0080567)", "pathway": " (mmu:207958)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25036826;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]; Hence, we concluded that there is different transcriptional control mechanism between mALG11 and hALG11, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7W8;Q8BL38", "ec_number_list": "2.4.1.131", "go_molecular_function": "GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 781, "hit_score": 0.5, "record_id": "Q3TZM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUE8-1", "uniprot_id": "ANR40_MOUSE", "mass": 40560.0, "length": 363, "protein_name": "Ankyrin repeat domain-containing protein 40", "gene_name": "Ankrd40", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 40 isoform 1", "refseq_ac": "NP_082075", "gene_names_uniprotkb": "Ankrd40", "gene_names_refseq": "1110011C06Rik; 5530600A18Rik; Ankrd40; Gcap15", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 40", "protein_names_refseq": "ankyrin repeat domain-containing protein 40 isoform 1; ankyrin repeat domain-containing protein 40; granule cell antiserum positive 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:71452)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;22517741;22645316;32782141;32848054;40021952;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUF0;Q8R595;Q9CU71", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SUE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61839-1", "uniprot_id": "ANFC_MOUSE", "mass": 13320.0, "length": 126, "protein_name": "C-type natriuretic peptide", "gene_name": "Nppc", "organism": "Mouse", "refseq_name": "C-type natriuretic peptide preproprotein", "refseq_ac": "NP_035063", "gene_names_uniprotkb": "Nppc; Cnp", "gene_names_refseq": "CNP; Nppc; lbab", "protein_names_uniprotkb": "C-type natriuretic peptide", "protein_names_refseq": "C-type natriuretic peptide preproprotein; C-type natriuretic peptide; natriuretic peptide precursor C; natriuretic peptide precursor type C", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); toxic shock syndrome (Disease Ontology:DOID:14115); depressive disorder (Disease Ontology:DOID:1596); aortic valve stenosis (Disease Ontology:DOID:1712); osteochondrodysplasia (Disease Ontology:DOID:2256); arteriosclerosis (Disease Ontology:DOID:2349); achondroplasia (Disease Ontology:DOID:4480); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:18159); (R-MMU-5578768)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11259675;12890708;17439653;37227779;37860954;7698765;8897953", "class_list": "", "function": "A single nucleotide mutation of Nppc is associated with dwarfism in lbab/lbab mice Publication Status: Online-Only, [RefSeq, PubMed]; Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice. Publication Status: Online-Only, [RefSeq, PubMed]; C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (PubMed:11259675). May also be vasoactive and natriuretic (By similarity). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:12890708). Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051427 hormone receptor binding;GO:0030250 guanylate cyclase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035483 gastric emptying;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006182 cGMP biosynthetic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61839-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NS69-1", "uniprot_id": "AMER3_MOUSE", "mass": 83159.0, "length": 780, "protein_name": "APC membrane recruitment protein 3", "gene_name": "Amer3", "organism": "Mouse", "refseq_name": "APC membrane recruitment protein 3", "refseq_ac": "NP_998892", "gene_names_uniprotkb": "Amer3; Fam123c", "gene_names_refseq": "9430069J07Rik; Amer3; Fam123c", "protein_names_uniprotkb": "APC membrane recruitment protein 3; Amer3; Protein FAM123C", "protein_names_refseq": "APC membrane recruitment protein 3; family with sequence similarity 123, member C; protein FAM123C", "tax_id": 10090, "disease": "", "pathway": " (mmu:211383)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS82", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NS69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVM2-1", "uniprot_id": "ANTRL_MOUSE", "mass": 70443.0, "length": 641, "protein_name": "Anthrax toxin receptor-like", "gene_name": "Antxrl", "organism": "Mouse", "refseq_name": "anthrax toxin receptor-like precursor", "refseq_ac": "NP_766396", "gene_names_uniprotkb": "Antxrl", "gene_names_refseq": "1700112N15Rik; 4933430J11; Antxrl", "protein_names_uniprotkb": "Anthrax toxin receptor-like", "protein_names_refseq": "anthrax toxin receptor-like precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:239029)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNF3", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K592-1", "uniprot_id": "AMHR2_MOUSE", "mass": 61195.0, "length": 568, "protein_name": "Anti-Muellerian hormone type-2 receptor", "gene_name": "Amhr2", "organism": "Mouse", "refseq_name": "anti-Muellerian hormone type-2 receptor precursor", "refseq_ac": "NP_653130", "gene_names_uniprotkb": "Amhr2", "gene_names_refseq": "Amhr2; C14; Misiir; Misrii; Mrii", "protein_names_uniprotkb": "Anti-Muellerian hormone type-2 receptor; 2.7.11.30; AMH type II receptor; Anti-Muellerian hormone type II receptor; MIS type II receptor; MISRII; MRII", "protein_names_refseq": "AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; anti-Muellerian hormone type-2 receptor precursor; anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone type 2 receptor delta 2; anti-Mullerian hormone type 2 receptor delta 9/10", "tax_id": 10090, "disease": "persistent Mullerian duct syndrome (Disease Ontology:DOID:0050791); leiomyosarcoma (Disease Ontology:DOID:1967); dysgerminoma (Disease Ontology:DOID:4441)", "pathway": " (mmu:110542); (R-MMU-201451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23624077;9299437", "class_list": "", "function": "May act as a dominant negative inhibitor of AMH signaling., [UniProtKB, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone (AMH) (PubMed:23624077)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8VHE2;A0A2R8W6H9;F6V9X7;Q0VDQ4;R4JKA2;R4JNM3", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0008584 male gonad development;GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K592-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCU0-1", "uniprot_id": "ANGE1_MOUSE", "mass": 75254.0, "length": 667, "protein_name": "RNA 2',3'-cyclic phosphatase ANGEL1", "gene_name": "Angel1", "organism": "Mouse", "refseq_name": "RNA 2',3'-cyclic phosphatase ANGEL1", "refseq_ac": "NP_653107", "gene_names_uniprotkb": "Angel1; Kiaa0759", "gene_names_refseq": "1110030H02Rik; Angel1; mKIAA0759", "protein_names_uniprotkb": "RNA 2',3'-cyclic phosphatase ANGEL1; 3.-.-.-", "protein_names_refseq": "RNA 2',3'-cyclic phosphatase ANGEL1; protein angel homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68737)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Exhibits weak RNA 2',3'-cyclic phosphatase, catalyzing the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group. Plays a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DU16", "ec_number_list": "3.-.-.-", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0003730 mRNA 3'-UTR binding;GO:0160272 RNA 2',3'-cyclic phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922H1-1", "uniprot_id": "ANM3_MOUSE", "mass": 59471.0, "length": 528, "protein_name": "Protein arginine N-methyltransferase 3", "gene_name": "Prmt3", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 3", "refseq_ac": "NP_598501", "gene_names_uniprotkb": "Prmt3; Hrmt1l3", "gene_names_refseq": "2010005E20Rik; 2410018A17Rik; Hrmt1l3; Prmt3", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 3; 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein methyltransferase-like 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; protein arginine N-methyltransferase 3; protein arginine methyltransferase 3", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:71974); (R-MMU-3214858); (R-MMU-8876725)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15473865;17439947;21183079;21750661;31378783;37639603;38200452", "class_list": "", "function": "Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity. Erratum:[Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2504746122. doi: 10.1073/pnas.2504746122. PMID: 40153472], [RefSeq, PubMed]; PRMT3 methylates HIF-1alpha to enhance the vascular calcification induced by chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (By similarity). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:15473865, PubMed:17439947). Also appears to methylate other ribosomal proteins (PubMed:15473865). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (By similarity). Promotes osteogenesis (PubMed:31378783)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The zinc-finger domain of mouse PRMT3 is necessary & sufficient for binding to human rpS2. rpS2 is methylated by PRMT3, implicating PRMT3 in ribosomal function & in the regulation of protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2K1;Q80VU9;Q8BFV5", "ec_number_list": "2.1.1.319;2.1.1.321", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0018216 peptidyl-arginine methylation;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q922H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQM6-1", "uniprot_id": "ANR61_MOUSE", "mass": 46588.0, "length": 421, "protein_name": "Ankyrin repeat domain-containing protein 61", "gene_name": "Ankrd61", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 61 isoform 2", "refseq_ac": "NP_001297701", "gene_names_uniprotkb": "Ankrd61", "gene_names_refseq": "4921520G13Rik; Ankrd61", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 61", "protein_names_refseq": "ankyrin repeat domain-containing protein 61 isoform 2; ankyrin repeat domain-containing protein 61", "tax_id": 10090, "disease": "", "pathway": " (mmu:66729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W77", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8F1-1", "uniprot_id": "ALKB4_MOUSE", "mass": 33394.0, "length": 300, "protein_name": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4", "gene_name": "Alkbh4", "organism": "Mouse", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform 1", "refseq_ac": "NP_001334421", "gene_names_uniprotkb": "Alkbh4", "gene_names_refseq": "2010004B12Rik; Abj4; Alkbh4", "protein_names_uniprotkb": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; 1.14.11.-; 1.14.11.51; Alkylated DNA repair protein alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; Lysine-specific demethylase ALKBH4", "protein_names_refseq": "DNA N6-methyl adenine demethylase ALKBH4; alkB, alkylation repair homolog 4; alkylated DNA repair protein alkB homolog 4; alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform 1; alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; lysine-specific demethylase ALKBH4; probable alpha-ketoglutarate-dependent dioxygenase ABH4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72041)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23673617;25153837;30982744", "class_list": "", "function": "ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis. Publication Status: Online-Only, [RefSeq, PubMed]; ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction., [RefSeq, PubMed]; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (By similarity). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (PubMed:30982744)., [UniProtKB, UniProtKB, PubMed]; It has been shown that 6methyladenine (6 mA) deposition and removal are catalyzed by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA accumulation in genic elements corresponds with transcriptional silencing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1Y9", "ec_number_list": "1.14.11.51;4.2.99.18;1.14.11.-;1.14.11.33;1.14.11.27;1.14.11.79", "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0032451 demethylase activity;GO:0035516 broad specificity oxidative DNA demethylase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030496 midbody;GO:0070938 contractile ring", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0031032 actomyosin structure organization;GO:0036090 cleavage furrow ingression;GO:0070988 demethylation;GO:0141137 positive regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D8F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAX9-1", "uniprot_id": "APBP2_MOUSE", "mass": 66855.0, "length": 585, "protein_name": "Amyloid protein-binding protein 2", "gene_name": "Appbp2", "organism": "Mouse", "refseq_name": "amyloid protein-binding protein 2", "refseq_ac": "NP_080101", "gene_names_uniprotkb": "Appbp2; Kiaa0228", "gene_names_refseq": "1300003O07Rik; Appbp2; PAT1", "protein_names_uniprotkb": "Amyloid protein-binding protein 2; APP-BP2; Amyloid beta precursor protein-binding protein 2", "protein_names_refseq": "APP-BP2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; amyloid protein-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66884)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18780968;21952136;25428506;25428507;30084848;30779550;31219806;31599954;34428180;35820727;35978186", "class_list": "", "function": "Amyloid beta precursor protein gene is associated with Alzheimer's disease, [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (By similarity). The CRL2(APPBP2) complex negatively regulates beige adipocyte differentiation by mediating ubiquitination and degradation of PRDM16 (PubMed:35978186). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX12;Q80U61", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005874 microtubule;GO:0030659 cytoplasmic vesicle membrane;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway;GO:0160276 negative regulation of beige fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9DAX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAZ9-1", "uniprot_id": "ANCHR_MOUSE", "mass": 43272.0, "length": 389, "protein_name": "Abscission/NoCut checkpoint regulator", "gene_name": "Zfyve19", "organism": "Mouse", "refseq_name": "abscission/NoCut checkpoint regulator isoform 1", "refseq_ac": "NP_082330", "gene_names_uniprotkb": "Zfyve19; Anchr", "gene_names_refseq": "1500041L05Rik; ANCHR; Zfyve19", "protein_names_uniprotkb": "Abscission/NoCut checkpoint regulator; ANCHR; Zinc finger FYVE domain-containing protein 19", "protein_names_refseq": "abscission/NoCut checkpoint regulator isoform 1; abscission/NoCut checkpoint regulator; zinc finger FYVE domain-containing protein 19", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:72008)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;18630941;19131326;19144319;21183079;37672510;38816193", "class_list": "", "function": "Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity)., [UniProtKB]; Prevention of Portal-Tract Fibrosis in Zfyve19[-/-] Mouse Model with Adeno-Associated Virus Vector Delivering ZFYVE19., [RefSeq, PubMed]; ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV55;Q8VCV7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005813 centrosome;GO:0032154 cleavage furrow;GO:0030496 midbody;GO:0090543 Flemming body", "go_biological_process": "GO:0032466 negative regulation of cytokinesis;GO:0044878 mitotic cytokinesis checkpoint signaling;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DAZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D081-1", "uniprot_id": "ALG14_MOUSE", "mass": 24429.0, "length": 217, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG14", "gene_name": "Alg14", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine transferase subunit ALG14", "refseq_ac": "NP_077140", "gene_names_uniprotkb": "Alg14", "gene_names_refseq": "5430428G01Rik; Alg14", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG14; Asparagine-linked glycosylation 14 homolog", "protein_names_refseq": "UDP-N-acetylglucosamine transferase subunit ALG14 homolog; UDP-N-acetylglucosamine transferase subunit ALG14; asparagine-linked glycosylation 14 homolog", "tax_id": 10090, "disease": "congenital myasthenic syndrome 15 (Disease Ontology:DOID:0110658)", "pathway": " (mmu:66789); (R-MMU-446193)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Part of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharides are transferred from the lipid to nascent proteins by oligosaccharyltransferases. Functions as a protein-membrane adapter recruiting ALG13 at the cytoplasmic face of the endoplasmic reticulum, where the complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEP2", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 15150, "hit_score": 0.3, "record_id": "Q9D081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZQ5-1", "uniprot_id": "AOC1_MOUSE", "mass": 85424.0, "length": 751, "protein_name": "Diamine oxidase [copper-containing]", "gene_name": "Aoc1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Aoc1; Abp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Diamine oxidase [copper-containing]; 1.4.3.22; Amine oxidase copper domain-containing protein 1; Diamine oxidase; Histaminase", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76507); (R-MMU-211945); (R-MMU-6798695); (R-MMU-70921)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;28011936;30084848", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates in vitro are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R229;Q8VC36", "ec_number_list": "3.2.1.18;3.4.24.34;3.4.21.-;3.2.1.17;3.4.23.5;3.1.3.48;3.6.5.2;3.4.21.37;3.5.3.1;3.2.1.166;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.7.10.2;2.3.2.5;3.1.21.-;3.2.1.14;3.5.1.3;3.4.18.1;3.4.19.9", "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070062 extracellular exosome;GO:0005576 extracellular region", "go_biological_process": "GO:0009445 putrescine metabolic process;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812C9-1", "uniprot_id": "AOC2_MOUSE", "mass": 83583.0, "length": 757, "protein_name": "Amine oxidase [copper-containing] 2", "gene_name": "Aoc2", "organism": "Mouse", "refseq_name": "amine oxidase [copper-containing] 2", "refseq_ac": "NP_849263", "gene_names_uniprotkb": "Aoc2", "gene_names_refseq": "Aoc2; RAO", "protein_names_uniprotkb": "Amine oxidase [copper-containing] 2; 1.4.3.21; Amine oxidase copper-containing 2; RAO; Retina-specific copper amine oxidase", "protein_names_refseq": "amine oxidase [copper-containing] 2; amine oxidase, copper containing 2 (retina-specific); retina-specific amine oxidase; retina-specific copper amine oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:237940); (R-MMU-211945)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14585497;20485683;21750661;25428506;30899004", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for 2-phenylethylamine, tryptamine and tyramine. Could also act on methylamine and benzylamine but much less efficiently., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2A4J0;Q80WP3", "ec_number_list": "1.4.3.21;1.4.3.-;1.4.3.4", "go_molecular_function": "GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006584 catecholamine metabolic process;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q812C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33622-1", "uniprot_id": "APOC3_MOUSE", "mass": 10982.0, "length": 99, "protein_name": "Apolipoprotein C-III", "gene_name": "Apoc3", "organism": "Mouse", "refseq_name": "apolipoprotein C-III isoform b precursor", "refseq_ac": "NP_001276685", "gene_names_uniprotkb": "Apoc3", "gene_names_refseq": "Apoc3; apo-CIII; apoC-III", "protein_names_uniprotkb": "Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3", "protein_names_refseq": "apolipoprotein C-III isoform b precursor; apolipoprotein C3", "tax_id": 10090, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); apolipoprotein C-III deficiency (Disease Ontology:DOID:0111370); glucose intolerance (Disease Ontology:DOID:10603); open-angle glaucoma (Disease Ontology:DOID:1067); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); nephrotic syndrome (Disease Ontology:DOID:1184); cholestasis (Disease Ontology:DOID:13580); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); renal artery obstruction (Disease Ontology:DOID:2972); hyperlipoproteinemia type III (Disease Ontology:DOID:3145); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11814); (R-MMU-8963888); (R-MMU-8963901); (R-MMU-8964058); (R-MMU-975634)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "1478650;16876491;21750661;34428180;37689737;37972731;38232538;38743496;39173944", "class_list": "", "function": "A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3., [RefSeq, PubMed]; ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression. Publication Status: Online-Only, [RefSeq, PubMed]; Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury., [RefSeq, PubMed]; Apolipoprotein C3: form begets function. Review article, [RefSeq, PubMed]; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Elevated apolipoprotein C3 augments diabetic kidney disease and associated atherosclerosis in type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC58;Q9CPP9", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0055102 lipase inhibitor activity;GO:0070653 high-density lipoprotein particle receptor binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0034363 intermediate-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P33622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63268-1", "uniprot_id": "ACTH_MOUSE", "mass": 41877.0, "length": 376, "protein_name": "Actin, gamma-enteric smooth muscle", "gene_name": "Actg2", "organism": "Mouse", "refseq_name": "actin, gamma-enteric smooth muscle", "refseq_ac": "NP_033740", "gene_names_uniprotkb": "Actg2; Acta3; Actsg", "gene_names_refseq": "ACTA3; Act-4; Act4; Actg2; SMGA", "protein_names_uniprotkb": "Actin, gamma-enteric smooth muscle; 3.6.4.-; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin", "protein_names_refseq": "actin, gamma-enteric smooth muscle; alpha-actin-3; gamma-2-actin; smooth muscle gamma-actin", "tax_id": 10090, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:11468); (R-MMU-445355); (R-MMU-9764561); (R-MMU-9913351); (R-MMU-9958825)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "21750661;23911929;24337657;25428506;2747639;33300544;33725478;34428180;36264152;36288343", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Heterozygous Actg2[R257C] mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12718", "ec_number_list": "3.6.4.13;3.6.4.10;2.3.2.31;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.2;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;2.3.2.26;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0044297 cell body", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045471 response to ethanol;GO:0090131 mesenchyme migration;GO:0071354 cellular response to interleukin-6;GO:1905641 cellular response to acetaldehyde", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P63268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97429-1", "uniprot_id": "ANXA4_MOUSE", "mass": 35916.0, "length": 319, "protein_name": "Annexin A4", "gene_name": "Anxa4", "organism": "Mouse", "refseq_name": "annexin A4 isoform a", "refseq_ac": "NP_001318049", "gene_names_uniprotkb": "Anxa4; Anx4", "gene_names_refseq": "AIV; Anx4; Anxa4; Xanx-4", "protein_names_uniprotkb": "Annexin A4; Annexin IV; Annexin-4", "protein_names_refseq": "annexin A4 isoform a; annexin IV; annexin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:11746)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;26495903;26740625;30084848;32552056;34428180;35820727;36288343;37453647;37507081", "class_list": "glycogene", "function": "ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer., [RefSeq, PubMed]; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCL0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0030855 epithelial cell differentiation;GO:0001822 kidney development;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VM7-1", "uniprot_id": "ANR24_MOUSE", "mass": 106238.0, "length": 985, "protein_name": "Ankyrin repeat domain-containing protein 24", "gene_name": "Ankrd24", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 24 isoform 2", "refseq_ac": "NP_081756", "gene_names_uniprotkb": "Ankrd24", "gene_names_refseq": "4631433D01Rik; 5730519E19Rik; Ankrd24; D10Bur2e", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 24", "protein_names_refseq": "ankyrin repeat domain-containing protein 24 isoform 2; ankyrin repeat domain-containing protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:70615)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26401315;35175278", "class_list": "", "function": "ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points., [RefSeq, PubMed]; Component of the stereocilia rootlet in hair cells of inner ear. Bridges the apical plasma membrane with the lower rootlet and maintains normal distribution of TRIOBP, thereby reinforcing stereocilia insertion points and organizing rootlets for hearing with long-term resilience., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJV7;Q9CYE0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032420 stereocilium", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80VM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88512-1", "uniprot_id": "AP1G2_MOUSE", "mass": 87863.0, "length": 791, "protein_name": "AP-1 complex subunit gamma-like 2", "gene_name": "Ap1g2", "organism": "Mouse", "refseq_name": "AP-1 complex subunit gamma-like 2 isoform 1", "refseq_ac": "NP_031481", "gene_names_uniprotkb": "Ap1g2", "gene_names_refseq": "Adtg2; Ap1g2; G2ad", "protein_names_uniprotkb": "AP-1 complex subunit gamma-like 2; G2ad; Gamma2-adaptin", "protein_names_refseq": "AP-1 complex subunit gamma-like 2 isoform 1; AP-1 complex subunit gamma-like 2; gamma 2-adaptin", "tax_id": 10090, "disease": "", "pathway": " (mmu:11766); (R-MMU-432720)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;25428506;25605945;30084848;30779550;31219806;34428180;9762922", "class_list": "", "function": "May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)., [UniProtKB, UniProtKB]; This gene encodes the gamma-2 subunit of the adaptor protein complex 1 (AP-1). AP-1 complex is a heterotetramer comprised of two heavy and one each of medium and small subunits. The encoded protein is a heavy subunit of AP-1 complex that regulates polarized sorting of cargo at the trans-Golgi network and endosomes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDV3", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0016020 membrane;GO:0045202 synapse;GO:0010008 endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN05-1", "uniprot_id": "AP1S3_MOUSE", "mass": 18440.0, "length": 154, "protein_name": "AP-1 complex subunit sigma-3", "gene_name": "Ap1s3", "organism": "Mouse", "refseq_name": "AP-1 complex subunit sigma-3", "refseq_ac": "NP_898848", "gene_names_uniprotkb": "Ap1s3", "gene_names_refseq": "1190009B22; Ap1s3; Jr2; [s]3A", "protein_names_uniprotkb": "AP-1 complex subunit sigma-3; Adaptor protein complex AP-1 subunit sigma-1C; Adaptor-related protein complex 1 subunit sigma-1C; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin", "protein_names_refseq": "AP-1 complex subunit sigma-3; adapter-related protein complex 1 sigma-1C subunit; adapter-related protein complex 1 subunit sigma-1C; adaptor protein complex AP-1 sigma-1C subunit; adaptor protein complex AP-1 subunit sigma-1C; adaptor-related protein complex 1 subunit sigma-1C; clathrin assembly protein complex 1 sigma-1C small chain; golgi adaptor HA1/AP1 adaptin sigma-1C subunit; sigma 1C subunit of AP-1 clathrin; sigma-adaptin 1C; sigma1C-adaptin", "tax_id": 10090, "disease": "psoriasis 15 (Disease Ontology:DOID:0111281)", "pathway": " (mmu:252903); (R-MMU-2132295); (R-MMU-432720); (R-MMU-432722)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Involved in TLR3 trafficking (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005905 clathrin-coated pit;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:1903232 melanosome assembly;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0060155 platelet dense granule organization;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61313-1", "uniprot_id": "AP2B_MOUSE", "mass": 50373.0, "length": 459, "protein_name": "Transcription factor AP-2-beta", "gene_name": "Tfap2b", "organism": "Mouse", "refseq_name": "transcription factor AP-2-beta isoform 1", "refseq_ac": "NP_033360", "gene_names_uniprotkb": "Tfap2b; Tcfap2b", "gene_names_refseq": "AP-2(beta); AP2-beta; E130018K07Rik; Tcfap2b; Tfap2b", "protein_names_uniprotkb": "Transcription factor AP-2-beta; AP2-beta; Activating enhancer-binding protein 2-beta", "protein_names_refseq": "activating enhancer-binding protein 2 beta; transcription factor AP-2-beta isoform 1", "tax_id": 10090, "disease": "Char syndrome (Disease Ontology:DOID:0060563); angle-closure glaucoma (Disease Ontology:DOID:13550); patent ductus arteriosus (Disease Ontology:DOID:13832); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:21419); (R-MMU-8866904); (R-MMU-8866907); (R-MMU-9834899)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12504852;21750661;25187989;25428506;30084848;34428180;35820727;7555706", "class_list": "", "function": "Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEP1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WK7-1", "uniprot_id": "ANR54_MOUSE", "mass": 32486.0, "length": 299, "protein_name": "Ankyrin repeat domain-containing protein 54", "gene_name": "Ankrd54", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 54 isoform 1", "refseq_ac": "NP_659098", "gene_names_uniprotkb": "Ankrd54; Liar", "gene_names_refseq": "Ankrd54; C730048E16Rik; EST1068184; EST475269; Liar", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 54; Lyn-interacting ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain-containing protein 54 isoform 1; ankyrin repeat domain-containing protein 54; lyn-interacting ankyrin repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:223690)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;19064729;21750661;22527282;31219806;34428180", "class_list": "", "function": "Ankrd54 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation., [RefSeq, PubMed]; Liar is the first protein identified that specifically influences the nucleocytoplasmic shuttling of Btk and Txk and belongs to a rare group of known proteins carrying out this activity in a Crm1-dependent manner., [RefSeq, PubMed]; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPC5;Q3UZL7", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030496 midbody", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0045648 positive regulation of erythrocyte differentiation;GO:1902531 regulation of intracellular signal transduction;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q58Y75-1", "uniprot_id": "AGRF3_MOUSE", "mass": 108975.0, "length": 991, "protein_name": "Adhesion G protein-coupled receptor F3", "gene_name": "ADGRF3; Adgrf3", "organism": "Mouse", "refseq_name": "adhesion G-protein coupled receptor F3 precursor", "refseq_ac": "NP_001014416", "gene_names_uniprotkb": "ADGRF3; Adgrf3; Gm1041; Gpr113; Pcr113; Pgr23", "gene_names_refseq": "Adgrf3; Gm1041; Gpr113; Pgr23", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F3; G protein-coupled receptor 113; G protein-coupled receptor PGR23", "protein_names_refseq": "G protein coupled receptor Gpr113; G protein-coupled receptor 113; G-protein coupled receptor PGR23; adhesion G-protein coupled receptor F3 precursor; probable G-protein coupled receptor 113", "tax_id": 10090, "disease": "", "pathway": " (mmu:381628)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12679517;15780750;21750661", "class_list": "", "function": "Expression analyses indicate that Gpr113 expression is highly restricted to a subset of taste receptor cells., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 10, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "F8VPU1;Q80T50", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58Y75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3UZ78-1", "uniprot_id": "ADGB_MOUSE", "mass": 188556.0, "length": 1657, "protein_name": "Androglobin", "gene_name": "Adgb", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adgb; 9130014G24Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Androglobin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "21750661;22115833;34428180;35700329;36995441", "class_list": "", "function": "Probable chimeric globin with a bis-histidyl six-coordinate heme-iron atom through which it could bind dioxygen, carbon monoxide and nitric oxide (By similarity). Required for sperm flagellum formation and maturation of elongating spermatids, thus playing an essential role in male fertility (PubMed:35700329, PubMed:36995441)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5C7", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3UZ78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810N6-1", "uniprot_id": "ANR45_MOUSE", "mass": 27734.0, "length": 248, "protein_name": "Ankyrin repeat domain-containing protein 45", "gene_name": "Ankrd45", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 45 isoform 1", "refseq_ac": "NP_082940", "gene_names_uniprotkb": "Ankrd45", "gene_names_refseq": "4933409K03Rik; Ankrd45", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 45", "protein_names_refseq": "ankyrin repeat domain-containing protein 45 isoform 1; ankyrin repeat domain-containing protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:73844)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role during cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810N6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09813-1", "uniprot_id": "APOA2_MOUSE", "mass": 11309.0, "length": 102, "protein_name": "Apolipoprotein A-II", "gene_name": "Apoa2", "organism": "Mouse", "refseq_name": "apolipoprotein A-II preproprotein", "refseq_ac": "NP_001292478", "gene_names_uniprotkb": "Apoa2", "gene_names_refseq": "Alp-2; Apo-AII; ApoA-II; ApoAII; Apoa-2; Apoa2; Hdl-1", "protein_names_uniprotkb": "Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2", "protein_names_refseq": "apolipoprotein A-II preproprotein; apolipoprotein A2", "tax_id": 10090, "disease": "familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11807); (R-MMU-381426); (R-MMU-8957275); (R-MMU-8963888); (R-MMU-8963901); (R-MMU-975634)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "1683229;16876491;2118905;2426658;2514123;26495903;27756649;29618729;30084848;3089836;3095143;31361958;32152506;34428180;36495239;39627609", "class_list": "", "function": "High Apolipoprotein A-II is associated with acute-phase response and AA amyloidosis by conformational changes of plasma lipoprotein structure. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis., [RefSeq, PubMed]; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism., [UniProtKB]; Study reports a deterministic role for the B6 apoa2 gene polymorphism in respiratory rhythmogenesis. The in vivo inheritance pattern discloses a recessive effect of the B6 allele on the apnea phenotype, as the presence of both B6 alleles in the brain is required for transcript and trait expression; in contrast, apoa2 mRNA expression in the liver requires only one allele., [RefSeq, PubMed]; This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKX6;Q61317", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P09813-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21300-1", "uniprot_id": "ALD1_MOUSE", "mass": 35988.0, "length": 316, "protein_name": "Aldo-keto reductase family 1 member B7", "gene_name": "Akr1b7", "organism": "Mouse", "refseq_name": "aldo-keto reductase family 1 member B7", "refseq_ac": "NP_033861", "gene_names_uniprotkb": "Akr1b7; Avdp", "gene_names_refseq": "AR; Akr1b7; Avdp; MVDP", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member B7; 1.1.1.21; AR; Aldehyde reductase; Aldose reductase-related protein 1; MVDP; Vas deferens androgen-dependent protein", "protein_names_refseq": "aldehyde reductase; aldo-keto reductase family 1 member B7; aldose reductase-related protein 1; androgen regulated vas deferens protein; vas deferens androgen-dependent protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:11997); (R-MMU-193144)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1637719;19010934;2123194;31219806;33359683", "class_list": "", "function": "ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice., [RefSeq, PubMed]; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (PubMed:19010934). May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.21;1.1.1.300;1.1.1.372;1.1.1.54", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40753-1", "uniprot_id": "ANFB_MOUSE", "mass": 13756.0, "length": 121, "protein_name": "Natriuretic peptides B", "gene_name": "Nppb", "organism": "Mouse", "refseq_name": "natriuretic peptides B isoform 2 preproprotein", "refseq_ac": "NP_001274277", "gene_names_uniprotkb": "Nppb", "gene_names_refseq": "BNF; BNP; Iso-ANP; Nppb", "protein_names_uniprotkb": "Natriuretic peptides B; 5 kDa cardiac natriuretic peptide; BNP(77-121); BNP; Brain natriuretic factor prohormone; Brain natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; preproBNP; proBNP", "protein_names_refseq": "brain natriuretic factor prohormone; brain natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor type B; natriuretic peptides B isoform 2 preproprotein; natriuretic peptides B; preproBNP; proBNP; type-B natriuretic factor", "tax_id": 10090, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); polycystic kidney disease (Disease Ontology:DOID:0080322); COVID-19 (Disease Ontology:DOID:0080600); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); sickle cell anemia (Disease Ontology:DOID:10923); adult respiratory distress syndrome (Disease Ontology:DOID:11394); heart disease (Disease Ontology:DOID:114); hypertensive heart disease (Disease Ontology:DOID:11516); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); Kawasaki disease (Disease Ontology:DOID:13378); atherosclerosis (Disease Ontology:DOID:1936); nephrosis (Disease Ontology:DOID:2527); acute kidney failure (Disease Ontology:DOID:3021); liver cirrhosis (Disease Ontology:DOID:5082); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); systolic heart failure (Disease Ontology:DOID:9651); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18158)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10737768;8097440;8182124", "class_list": "", "function": "Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:8182124). May also function as a paracrine antifibrotic factor in the heart (PubMed:10737768). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:8182124). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0000165 MAPK cascade;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P40753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45377-1", "uniprot_id": "ALD2_MOUSE", "mass": 36121.0, "length": 316, "protein_name": "Aldose reductase-related protein 2", "gene_name": "Akr1b8", "organism": "Mouse", "refseq_name": "aldose reductase-related protein 2", "refseq_ac": "NP_032038", "gene_names_uniprotkb": "Akr1b8; Fgfrp", "gene_names_refseq": "Akr1b8; FR-1; Fgfrp; Fgrp", "protein_names_uniprotkb": "Aldose reductase-related protein 2; 1.1.1.21; AR; Aldehyde reductase; Fibroblast growth factor-regulated protein; Protein FR-1", "protein_names_refseq": "AR; aldehyde reductase; aldose reductase-related protein 2; fibroblast growth factor-regulated protein; protein FR-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14187); (R-MMU-193144)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21540332;22645316;25153642;28135057;28528544;31219806;34428180;34954342;36518763;37507081;7510692;7578036", "class_list": "", "function": "AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity. Publication Status: Online-Only, [RefSeq, PubMed]; Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JN4", "ec_number_list": "1.1.1.21;1.1.1.300;1.1.1.372;1.1.1.54", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0016918 retinal binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0042574 retinal metabolic process;GO:0019751 polyol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P45377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56380-1", "uniprot_id": "AP4A_MOUSE", "mass": 16989.0, "length": 147, "protein_name": "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]", "gene_name": "Nudt2", "organism": "Mouse", "refseq_name": "bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]", "refseq_ac": "NP_079815", "gene_names_uniprotkb": "Nudt2; Apah1", "gene_names_refseq": "2310051L06Rik; APAH1; Nudt2", "protein_names_uniprotkb": "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; 3.6.1.17; Ap4A hydrolase; Ap4Aase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2", "protein_names_refseq": "ap4A hydrolase; ap4Aase; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; bis(5'-nucleosyl)-tetraphosphatase; diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; nudix motif 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66401); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21402779;32432673;34824277;37507081", "class_list": "", "function": "Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta, [RefSeq, PubMed]; Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (PubMed:32432673)., [UniProtKB, UniProtKB, PubMed]; NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2U6;Q9D6V2", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.1.-;3.6.1.77;3.6.1.17;3.1.4.1;3.6.1.9;3.6.1.68;3.6.1.76", "go_molecular_function": "GO:0005525 GTP binding;GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0006915 apoptotic process;GO:0006167 AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63002-1", "uniprot_id": "TLE5_MOUSE", "mass": 22000.0, "length": 197, "protein_name": "TLE family member 5", "gene_name": "Tle5", "organism": "Mouse", "refseq_name": "TLE family member 5 isoform 1", "refseq_ac": "NP_034477", "gene_names_uniprotkb": "Tle5; Aes; Esp1; Grg5; Grg", "gene_names_refseq": "Aes; Esp1; Grg-5; Grg5; Grg; Tle5", "protein_names_uniprotkb": "TLE family member 5; Amino enhancer of split; Amino-terminal enhancer of split; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG", "protein_names_refseq": "TLE family member 5 isoform 1; amino-terminal enhancer of split; groucho-related protein 5; related to Drosophila groucho", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:14797)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11266540;12050133;21750661;30214018;37800625;8365415;8369224;9783587", "class_list": "", "function": "The results demonstrate that GRG5 has pleiotropic roles in stem cell biology functioning as a stemness factor and a neural fate specifier. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]; Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development., [UniProtKB, PubMed]; Unrevealed roles of extracellular enolase-1 (ENO1) in promoting glycolysis and pro-cancer activities in multiple myeloma via hypoxia-inducible factor 1alpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06195", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0040008 regulation of growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84084-1", "uniprot_id": "ARF5_MOUSE", "mass": 20530.0, "length": 180, "protein_name": "ADP-ribosylation factor 5", "gene_name": "Arf5", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor 5", "refseq_ac": "NP_031506", "gene_names_uniprotkb": "Arf5", "gene_names_refseq": "Arf5", "protein_names_uniprotkb": "ADP-ribosylation factor 5", "protein_names_refseq": "ADP-ribosylation factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:11844); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11950392;20921225;22111578;31201232;33300544;37507081;39927985;8947846", "class_list": "", "function": "A functional role for CAPS1 in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner., [RefSeq, PubMed]; GTP-binding protein involved in protein trafficking. Contributes to vesicle budding and uncoating at the Golgi apparatus. Regulates mTORC1 activity at the plasma membrane by promoting its recruitment to membrane ruffles, facilitating activation via the PI3K/Akt signaling pathway. Acts as an early responder to lysosomal damage and participates in lysosomal quality control pathways., [UniProtKB, UniProtKB]; Somal CAPS2 is associated with the Golgi membrane, and mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (members of the membrane-trafficking small GTPase family) to the Golgi membrane, [RefSeq, PubMed]; The exogenous expression of ARF5 reduced the tremor phenotype and restored the localization of Nav1.6 immunoreactivity to the AIS in ARF4(+/-)/ARF5(-/-) mice. There was a decrease in Nav1.6 protein in the axon intial segment of Purkinje cells, and the consequent tremors in ARF4(+/-)/ARF5(-/-) mice could be alleviated by the PC-specific expression of ARF5 using adeno-associated virus vectors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RTC5;P26437", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P84084-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0J4-1", "uniprot_id": "ANR53_MOUSE", "mass": 56738.0, "length": 497, "protein_name": "Ankyrin repeat domain-containing protein 53", "gene_name": "Ankrd53", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 53", "refseq_ac": "NP_083521", "gene_names_uniprotkb": "Ankrd53", "gene_names_refseq": "4930564N15Rik; Ankrd53", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 53", "protein_names_refseq": "ankyrin repeat domain-containing protein 53", "tax_id": 10090, "disease": "", "pathway": " (mmu:75305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QN79", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005819 spindle", "go_biological_process": "GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0031116 positive regulation of microtubule polymerization;GO:0060236 regulation of mitotic spindle organization;GO:1902412 regulation of mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V0J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60I26-1", "uniprot_id": "AL2CL_MOUSE", "mass": 108146.0, "length": 952, "protein_name": "ALS2 C-terminal-like protein", "gene_name": "Als2cl", "organism": "Mouse", "refseq_name": "ALS2 C-terminal-like protein", "refseq_ac": "NP_001139531", "gene_names_uniprotkb": "Als2cl", "gene_names_refseq": "79H19D; 79H19E; Als2cl; D930044G19Rik; mRn.49018", "protein_names_uniprotkb": "ALS2 C-terminal-like protein", "protein_names_refseq": "ALS2 C-terminal-like protein; mFLJ00189 protein", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 2 (Disease Ontology:DOID:0060194); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:235633); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12140191;15388334;16473597;17239822;21750661;30084848;34428180", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAQ8;Q8C0K7;Q8K468;Q8R222", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007032 endosome organization;GO:0016197 endosomal transport;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60I26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62148-1", "uniprot_id": "AL1A2_MOUSE", "mass": 56626.0, "length": 518, "protein_name": "Retinal dehydrogenase 2", "gene_name": "Aldh1a2", "organism": "Mouse", "refseq_name": "retinal dehydrogenase 2", "refseq_ac": "NP_033048", "gene_names_uniprotkb": "Aldh1a2; Aldh1a7; Raldh2", "gene_names_refseq": "Aldh1a2; Aldh1a7; Raldh1; Raldh2", "protein_names_uniprotkb": "Retinal dehydrogenase 2; 1.2.1.36; ALDH1A2; Aldehyde dehydrogenase family 1 member A2; RALDH 2; RALDH(II); RalDH2; Retinaldehyde-specific dehydrogenase type 2", "protein_names_refseq": "RALDH 2; RALDH(II); alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase family 1 member A2; retinal dehydrogenase 2; retinaldehyde dehydrogenase 2; retinaldehyde-specific dehydrogenase type 2", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:19378); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15911617;22075477;25428506;34428180;8797830;9106168", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:15911617, PubMed:8797830). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8797830). Displays complete lack of activity with citral (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6DI79", "ec_number_list": "1.2.1.36;1.2.1.19;1.2.1.3;1.2.1.28;2.7.10.1;1.1.1.-;1.1.1.62;1.1.1.105;1.7.1.-", "go_molecular_function": "GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0016918 retinal binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0001889 liver development;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64G17-1", "uniprot_id": "AN32C_MOUSE", "mass": 14066.0, "length": 123, "protein_name": "Putative acidic leucine-rich nuclear phosphoprotein 32 family member C", "gene_name": "Anp32c", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Anp32c; Anp32-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative acidic leucine-rich nuclear phosphoprotein 32 family member C", "protein_names_refseq": "", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15895553", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64G17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAK3-1", "uniprot_id": "ANM8_MOUSE", "mass": 45276.0, "length": 394, "protein_name": "Protein arginine N-methyltransferase 8", "gene_name": "Prmt8", "organism": "Mouse", "refseq_name": "protein arginine N-methyltransferase 8", "refseq_ac": "NP_958759", "gene_names_uniprotkb": "Prmt8; Hrmt1l4", "gene_names_refseq": "Hrmt1l3; Hrmt1l4; Prmt8", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 8; 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4", "protein_names_refseq": "HMT1 hnRNP methyltransferase-like 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; protein arginine N-methyltransferase 4; protein arginine N-methyltransferase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:381813)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12923295;17512914;35275616;35818334", "class_list": "", "function": "PRMT8 Attenuates Cerebral Ischemia/Reperfusion Injury via Modulating Microglia Activation and Polarization to Suppress Neuroinflammation by Upregulating Lin28a., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS., [UniProtKB, UniProtKB]; Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7M6Z2", "ec_number_list": "2.1.1.319;2.1.1.321", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0051260 protein homooligomerization;GO:0006355 regulation of DNA-templated transcription;GO:0006479 protein methylation;GO:0018216 peptidyl-arginine methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PAK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD24-1", "uniprot_id": "AN13D_MOUSE", "mass": 68076.0, "length": 605, "protein_name": "Ankyrin repeat domain-containing protein 13D", "gene_name": "Ankrd13d", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 13D", "refseq_ac": "NP_080996", "gene_names_uniprotkb": "Ankrd13d", "gene_names_refseq": "0710001P18Rik; Ankrd13d", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 13D", "protein_names_refseq": "ankyrin repeat domain-containing protein 13D", "tax_id": 10090, "disease": "", "pathway": " (mmu:68423)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;25428506;30084848", "class_list": "", "function": "Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9A8", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0002091 negative regulation of receptor internalization;GO:0048259 regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PD24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT36-1", "uniprot_id": "AGRA3_MOUSE", "mass": 144697.0, "length": 1310, "protein_name": "Adhesion G protein-coupled receptor A3", "gene_name": "Adgra3", "organism": "Mouse", "refseq_name": "adhesion G protein-coupled receptor A3 precursor", "refseq_ac": "NP_598672", "gene_names_uniprotkb": "Adgra3; Gpr125", "gene_names_refseq": "3830613O22Rik; Adgra3; Gpr125; Tem5-like", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor A3; G protein-coupled receptor 125", "protein_names_refseq": "G protein coupled receptor Gpr125; G protein-coupled receptor 125; adhesion G protein-coupled receptor A3 precursor; probable G-protein coupled receptor 125", "tax_id": 10090, "disease": "", "pathway": " (mmu:70693)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17882221;18834514;30899004;31219806;36688818;37828378", "class_list": "", "function": "Data show that GPR125 is specifically expressed in cells of the choroid plexus and is upregulated following traumatic brain injury. Publication Status: Online-Only, [RefSeq, PubMed]; GPR125+ multipotent adult stem cells generated derivatives of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GPR125 during differentiation into GPR125- cells, [RefSeq, PubMed]; Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice., [RefSeq, PubMed]; Orphan receptor that may have a role in planar cell polarity pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9QK56;Q6PE67;Q8VE71", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q7TT36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TL1-1", "uniprot_id": "ADCY2_MOUSE", "mass": 123270.0, "length": 1090, "protein_name": "Adenylate cyclase type 2", "gene_name": "Adcy2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Adcy2; Kiaa1060", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate cyclase type 2; 4.6.1.1; ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (R-MMU-163615); (R-MMU-170660); (R-MMU-170670); (R-MMU-418597); (R-MMU-5610787)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "25428506;29187734", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFU6", "ec_number_list": "3.6.5.-;4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045121 membrane raft", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0035556 intracellular signal transduction;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80TL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WC7-1", "uniprot_id": "AGFG2_MOUSE", "mass": 48968.0, "length": 479, "protein_name": "Arf-GAP domain and FG repeat-containing protein 2", "gene_name": "Agfg2", "organism": "Mouse", "refseq_name": "arf-GAP domain and FG repeat-containing protein 2 isoform 2", "refseq_ac": "NP_835456", "gene_names_uniprotkb": "Agfg2; Hrbl; Rabr", "gene_names_refseq": "A630095P14Rik; Agfg2; Hrbl; RAB-R; RABR", "protein_names_uniprotkb": "Arf-GAP domain and FG repeat-containing protein 2; HIV-1 Rev-binding protein-like protein; RAB-R; Rev/Rex activation domain-binding protein related", "protein_names_refseq": "HIV-1 Rev-binding protein-like protein; arf-GAP domain and FG repeat-containing protein 2 isoform 2; arf-GAP domain and FG repeats-containing protein 2; rev/Rex activation domain-binding protein related", "tax_id": 10090, "disease": "", "pathway": " (mmu:231801)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21750661;22517741;22645316;32848054;33300544;34428180;35820727;35984892;36852467;37828378;40021952;40885482;9446614", "class_list": "", "function": "This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKS5;Q99J67", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q80WC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812A3-1", "uniprot_id": "ANR23_MOUSE", "mass": 34348.0, "length": 306, "protein_name": "Ankyrin repeat domain-containing protein 23", "gene_name": "Ankrd23", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein 23 isoform 2", "refseq_ac": "NP_001297450", "gene_names_uniprotkb": "Ankrd23; Darp", "gene_names_refseq": "1110058D09Rik; 2310041C05Rik; Ankrd23; Darp; Gm42417; MARP3", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 23; Diabetes-related ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain-containing protein 23 isoform 2; ankyrin repeat domain-containing protein 23; diabetes-realted ankyrin repeat protein; diabetes-related ankyrin repeat protein", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:78321)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12456686;17392382;19028694;21750661;24736439;25428506;26398569;27889934;28754631", "class_list": "", "function": "Ankrd23(-/-) mice exhibit limited ability to form collateral arteries following femoral artery occlusion compared to WT mice. Further research will be required to determine whether Ankrd23 plays an important role in mechanically induced vascular remodeling of the arterial tree in skeletal muscle. Review article, [RefSeq, PubMed]; CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload. Erratum:[PLoS One. 2015 Mar 06;10(3):e0118523. doi: 10.1371/journal.pone.0118523. PMID: 25747160] Publication Status: Online-Only, [RefSeq, PubMed]; DARP plays important structural and gene regulatory roles in skeletal muscle., [RefSeq, PubMed]; DARP regulates glucose disposal in skeletal muscle and thus modifies the glucose homeostasis by modulating AMPK activity. Publication Status: Online-Only, [RefSeq, PubMed]; Dapr is involved in the PI3K signaling cascade, potentially acting as a scaffold protein for PKB and coordinating its compartmentalization during differentiation., [RefSeq, PubMed]; Investigation of potential role in energy metabolism, [RefSeq, PubMed]; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression., [UniProtKB]; Results showed expression of myoblast differentiation marker genes were increased by interference and reduced by ANKRD23 overexpression, indicating that ANKRD23 played a negative role in the myoblast differentiation; discovered a long non-coding RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene. Thus, AK004293 had no significant effect on the expression of myoblast differentiation maker genes and ANKRD23., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0031432 titin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0014704 intercalated disc", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035994 response to muscle stretch;GO:0060297 regulation of sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q812A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFZ3-1", "uniprot_id": "ACTBL_MOUSE", "mass": 42004.0, "length": 376, "protein_name": "Beta-actin-like protein 2", "gene_name": "Actbl2", "organism": "Mouse", "refseq_name": "beta-actin-like protein 2", "refseq_ac": "NP_780706", "gene_names_uniprotkb": "Actbl2", "gene_names_refseq": "4732495G21Rik; Actbl2", "protein_names_uniprotkb": "Beta-actin-like protein 2; Kappa-actin", "protein_names_refseq": "beta-actin-like protein 2; kappa-actin", "tax_id": 10090, "disease": "Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004)", "pathway": " (mmu:238880)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;22645316;23911929;28011936;33725478;34428180;34887587;37828378;41018975", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BFZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG27-1", "uniprot_id": "ACTL9_MOUSE", "mass": 45771.0, "length": 415, "protein_name": "Actin-like protein 9", "gene_name": "Actl9", "organism": "Mouse", "refseq_name": "actin-like protein 9", "refseq_ac": "NP_899105", "gene_names_uniprotkb": "Actl9; Actl7c", "gene_names_refseq": "1700029I08Rik; Actl9", "protein_names_uniprotkb": "Actin-like protein 9", "protein_names_refseq": "actin-like 7-alpha; actin-like 7A; actin-like protein 9", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); spermatogenic failure 53 (Disease Ontology:DOID:0112279); nemaline myopathy (Disease Ontology:DOID:3191); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:69481)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33626338;35820727", "class_list": "", "function": "Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice., [RefSeq, PubMed]; Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497R1;Q5EBK5", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0061827 sperm head;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle;GO:0033011 perinuclear theca", "go_biological_process": "GO:0009566 fertilization;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CG27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R034-1", "uniprot_id": "APC13_MOUSE", "mass": 8346.0, "length": 74, "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "Anapc13", "organism": "Mouse", "refseq_name": "anaphase-promoting complex subunit 13", "refseq_ac": "NP_852059", "gene_names_uniprotkb": "Anapc13", "gene_names_refseq": "1810004D07Rik; APC13; Anapc13; SWM1", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 13; APC13; Cyclosome subunit 13", "protein_names_refseq": "anaphase-promoting complex subunit 13; cyclosome subunit 13; cylosome subunit 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:69010); (R-MMU-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0141198 protein branched polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1Q3-1", "uniprot_id": "ANGL7_MOUSE", "mass": 39014.0, "length": 337, "protein_name": "Angiopoietin-related protein 7", "gene_name": "Angptl7", "organism": "Mouse", "refseq_name": "angiopoietin-related protein 7 precursor", "refseq_ac": "NP_001034643", "gene_names_uniprotkb": "Angptl7", "gene_names_refseq": "Angptl7", "protein_names_uniprotkb": "Angiopoietin-related protein 7; Angiopoietin-like protein 7", "protein_names_refseq": "angiopoietin-like protein 7; angiopoietin-related protein 7 precursor; angiopoietin-related protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:654812)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;25622036;25652910;26495903;26973239;31219806;31835268;32786125;34428180;36192519;37319434;38497513", "class_list": "", "function": "ANGPTL7 and Its Role in IOP and Glaucoma., [RefSeq, PubMed]; ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; Angptl7 is a factor that promotes pro-inflammatory responses in macrophages through the P38 MAPK signaling pathway, [RefSeq, PubMed]; Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation., [RefSeq, PubMed]; Angptl7 was indispensable for bone marrow microenvironment to support hematopoietic stem cells repopulation Publication Status: Online-Only, [RefSeq, PubMed]; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (By similarity). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036)., [UniProtKB, UniProtKB, PubMed]; The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment., [RefSeq, PubMed]; When MC3T3-E1 cells were exposed to osteogenic medium, there was a significant increase in ANGPTL7, and overexpression of ANGPTL7 markedly promoted cell proliferation, ALP activity, and mineralization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007596 blood coagulation;GO:1903053 regulation of extracellular matrix organization;GO:1901346 negative regulation of vasculature development involved in avascular cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8R1Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDB2-1", "uniprot_id": "ALG12_MOUSE", "mass": 54543.0, "length": 486, "protein_name": "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "gene_name": "Alg12", "organism": "Mouse", "refseq_name": "dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1", "refseq_ac": "NP_001135829", "gene_names_uniprotkb": "Alg12", "gene_names_refseq": "Alg12; ECM39", "protein_names_uniprotkb": "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; 2.4.1.260; Asparagine-linked glycosylation protein 12 homolog; Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; Mannosyltransferase ALG12 homolog", "protein_names_refseq": "asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase); asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase); asparagine-linked glycosylation protein 12 homolog; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform 1; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1, 6-mannosyltransferase; mannosyltransferase ALG12 homolog", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ig (Disease Ontology:DOID:0080559)", "pathway": " (mmu:223774); (R-MMU-446193)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12200473;18299400;21106106;21750661;21952136;23818223;25428506;30084848;40997131", "class_list": "glycogene;glycosyltransferase", "function": "Data indicate that each of the mutations in the GC-rich sequence and YY1-binding element reduced asparagine-linked glycosylation 12 homolog (ALG12 promoter activity, and the combination of these mutations additively decreased reporter activity., [RefSeq, PubMed]; Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQK8", "ec_number_list": "2.4.1.-;2.4.1.260", "go_molecular_function": "GO:0000009 alpha-1,6-mannosyltransferase activity;GO:0052917 dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 1244, "hit_score": 1.5, "record_id": "Q8VDB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XE4-1", "uniprot_id": "ACY3_MOUSE", "mass": 35286.0, "length": 318, "protein_name": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)", "gene_name": "Acy3", "organism": "Mouse", "refseq_name": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1", "refseq_ac": "NP_001289408", "gene_names_uniprotkb": "Acy3; Aspa2", "gene_names_refseq": "0610006H10Rik; AA3; AAIII; Acy-3; Acy3; HCBP1", "protein_names_uniprotkb": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); 3.5.1.114; AAIII; ACY-3; Acylase III; Aminoacylase III; Aminoacylase-3; Aspartoacylase-2; HCBP1; Hepatitis C virus core-binding protein 1", "protein_names_refseq": "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) isoform 1; N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); acylase III; aminoacylase III; aspartoacylase (aminoacylase) 3; aspartoacylase-2; hepatitis C virus core-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71670); (R-MMU-5423646)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14656720;17012540;17434493;20921362;21750661;23010594", "class_list": "", "function": "A 16A resolution model of the AAIII dimer., [RefSeq, PubMed]; Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus that may by implicated in HCV pathogenesis., [RefSeq, PubMed]; Data suggest that in kidney proximal tubules, aminoacylase III plays an important role in deacetylating mercapturic acids, [RefSeq, PubMed]; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids., [UniProtKB, PubMed, PubMed]; Structures, in conjunction with biochemical data, indicated that AA3 mediates substrate specificity through van der Waals interactions providing a dynamic interaction interface, which facilitates a diverse range of substrates, [RefSeq, PubMed]; This gene encodes a member of the aminoacylase family of enzymes. This enzyme specifically deacetylates N-acetyl aromatic amino acids and mercapturic acids. Action of this enzyme on metabolites of the environmental contaminant trichloroethylene leads to the generation of toxic products that may lead to kidney failure. This protein has been found to bind to the hepatitis C virus core protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP59;Q9DD17", "ec_number_list": "3.5.1.114;3.5.1.14", "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91XE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99K28-1", "uniprot_id": "ARFG2_MOUSE", "mass": 56598.0, "length": 520, "protein_name": "ADP-ribosylation factor GTPase-activating protein 2", "gene_name": "Arfgap2", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 2 isoform 1", "refseq_ac": "NP_001159496", "gene_names_uniprotkb": "Arfgap2; Zfp289; Znf289", "gene_names_refseq": "2310032E02Rik; Arfgap2; Zfp289", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; GTPase-activating protein ZNF289; Zinc finger protein 289", "protein_names_refseq": "ADP-ribosylation factor GTPase activating protein 2; ADP-ribosylation factor GTPase-activating protein 2 isoform 1; ARF GAP 2; GTPase-activating protein ZNF289; zinc finger protein 289", "tax_id": 10090, "disease": "", "pathway": " (mmu:77038); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11278321;17242355;21183079;26495903;32848054;34428180;35820727", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)., [UniProtKB, PubMed]; This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9D758;Q9JIH1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q99K28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYR6-1", "uniprot_id": "AGM1_MOUSE", "mass": 59453.0, "length": 542, "protein_name": "Phosphoacetylglucosamine mutase", "gene_name": "Pgm3", "organism": "Mouse", "refseq_name": "phosphoacetylglucosamine mutase isoform 2", "refseq_ac": "NP_001157218", "gene_names_uniprotkb": "Pgm3; Agm1; Pgm-3", "gene_names_refseq": "2810473H05Rik; Agm1; PAGM; Pgm-3; Pgm3", "protein_names_uniprotkb": "Phosphoacetylglucosamine mutase; 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; PAGM; PGM 3; Phosphoglucomutase-3", "protein_names_refseq": "GlcNAc-P mutase; N-acetylglucosamine-phosphate mutase; PGM 3; acetylglucosamine phosphomutase; phosphoacetylglucosamine mutase isoform 2; phosphoacetylglucosamine mutase", "tax_id": 10090, "disease": "immunodeficiency 23 (Disease Ontology:DOID:0111953); cancer (Disease Ontology:DOID:162); teratoma (Disease Ontology:DOID:3307); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:109785); (R-MMU-446210)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;17548465;21183079;31219806", "class_list": "glycogene", "function": "Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation., [UniProtKB, UniProtKB]; Two hypomorphic alleles of mouse Pgm3 are described and specific physiological consequences of a graded reduction in Pgm3 activity and global UDP-GlcNAc levels, are shown., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 40, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RS40;Q543F9", "ec_number_list": "5.4.2.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004610 phosphoacetylglucosamine mutase activity", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0005975 carbohydrate metabolic process;GO:0006493 protein O-linked glycosylation;GO:0030097 hemopoiesis;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CYR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5P4-1", "uniprot_id": "ADAD2_MOUSE", "mass": 59299.0, "length": 561, "protein_name": "Adenosine deaminase domain-containing protein 2", "gene_name": "Adad2", "organism": "Mouse", "refseq_name": "adenosine deaminase domain-containing protein 2", "refseq_ac": "NP_083704", "gene_names_uniprotkb": "Adad2", "gene_names_refseq": "4930403J07Rik; Adad2", "protein_names_uniprotkb": "Adenosine deaminase domain-containing protein 2", "protein_names_refseq": "adenosine deaminase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75773)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "32665638;36698249;37428816", "class_list": "", "function": "ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility. Publication Status: Online-Only, [RefSeq, PubMed]; ADAD2 functions in spermiogenesis and piRNA biogenesis in mice., [RefSeq, PubMed]; Required for male fertility and normal male germ cell differentiation., [UniProtKB, PubMed]; Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQL4", "ec_number_list": "", "go_molecular_function": "GO:0008251 tRNA-specific adenosine deaminase activity;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0007286 spermatid development;GO:0006382 adenosine to inosine editing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D5P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EST5-1", "uniprot_id": "AN32B_MOUSE", "mass": 31079.0, "length": 272, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "gene_name": "Anp32b", "organism": "Mouse", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member B", "refseq_ac": "NP_570959", "gene_names_uniprotkb": "Anp32b; Pal31", "gene_names_refseq": "2410015B15Rik; Anp32b; PAL31; PHAPI2a; Ssp29", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member B; Proliferation-related acidic leucine-rich protein PAL31", "protein_names_refseq": "acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic leucine-rich nuclear phosphoprotein 32 family member B; acidic protein rich in leucines; proliferation related acidic leucine rich protein PAL31", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:67628)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11162633;15895553;17208939;19524510;20173027;21636789;25428507;25605945;30890743;32231671;34359074;34428180;37074204;37137487;39627609", "class_list": "", "function": "ANP32B suppresses B-cell acute lymphoblastic leukemia through activation of PU.1 in mice., [RefSeq, PubMed]; ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells., [RefSeq, PubMed]; Data demonstrate a hierarchy of importance for the mammalian Anp32 genes, with Anp32b being the most critical for normal development., [RefSeq, PubMed]; Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus., [RefSeq, PubMed]; Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:21636789). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (By similarity). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (By similarity). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (PubMed:30890743)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AVH9;Q566J4", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046827 positive regulation of protein export from nucleus;GO:0000082 G1/S transition of mitotic cell cycle;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9EST5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHX6-1", "uniprot_id": "ALLC_MOUSE", "mass": 46294.0, "length": 414, "protein_name": "Probable inactive allantoicase", "gene_name": "Allc", "organism": "Mouse", "refseq_name": "probable inactive allantoicase", "refseq_ac": "NP_444386", "gene_names_uniprotkb": "Allc", "gene_names_refseq": "1700012B22Rik; Alc; Allc", "protein_names_uniprotkb": "Probable inactive allantoicase; Allantoate amidinohydrolase", "protein_names_refseq": "allantoate amidinohydrolase; probable allantoicase; probable inactive allantoicase", "tax_id": 10090, "disease": "", "pathway": " (mmu:94041)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11406280;11852104;12036579", "class_list": "", "function": "The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals., [UniProtKB, PubMed]; The loss of allantoicase activity in mouse is due to a low substrate affinity and to a reduced expression level of the enzyme., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QL21", "ec_number_list": "", "go_molecular_function": "GO:0004037 allantoicase activity", "go_cellular_component": "", "go_biological_process": "GO:0051592 response to calcium ion;GO:0009268 response to pH;GO:0000256 allantoin catabolic process;GO:0032026 response to magnesium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JHX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ10-1", "uniprot_id": "ANX10_MOUSE", "mass": 37290.0, "length": 324, "protein_name": "Annexin A10", "gene_name": "Anxa10", "organism": "Mouse", "refseq_name": "annexin A10 isoform 1", "refseq_ac": "NP_001129561", "gene_names_uniprotkb": "Anxa10", "gene_names_refseq": "Anxa10", "protein_names_uniprotkb": "Annexin A10; Annexin-10", "protein_names_refseq": "annexin A10 isoform 1; annexin-10", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:26359)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10458909;27507697;37666806;37871012", "class_list": "", "function": "Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. Erratum:[Cell Death Dis. 2023 Oct 16;14(10):683. doi: 10.1038/s41419-023-06151-x. PMID: 37845204] Publication Status: Online-Only, [RefSeq, PubMed]; Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward beta-Cell Failure., [RefSeq, PubMed]; Spinal nerve ligation (SNL) induced persistent upregulation of annexin A10 mRNA and protein in the spinal cord of mice. annexin A10 siRNA partially prevented SNL-induced mechanical allodynia and heat hyperalgesia. Findings suggest that annexin A10 might be a novel target in the treatment of neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGJ1", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0012506 vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZ10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV08-1", "uniprot_id": "APJ_MOUSE", "mass": 42266.0, "length": 377, "protein_name": "Apelin receptor", "gene_name": "Aplnr", "organism": "Mouse", "refseq_name": "apelin receptor", "refseq_ac": "NP_035914", "gene_names_uniprotkb": "Aplnr; Agtrl1; Apj", "gene_names_refseq": "APJ; Agtrl1; Aplnr; msr/apj", "protein_names_uniprotkb": "Apelin receptor; Angiotensin receptor-like 1; G protein-coupled receptor APJ; MSR", "protein_names_refseq": "G-protein coupled receptor APJ; MSR; angiotensin receptor-like 1; apelin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:23796); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10473142;11744380;15087458;21750661;22810587;26611206;28371822;28663440;28854362;28890073;34428180", "class_list": "", "function": "APJ exerts the hypotensive effect in vivo and plays a counterregulatory role against the pressor action of angiotensin II, [RefSeq, PubMed]; Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels., [RefSeq, PubMed]; G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway leading to internalization of the receptor (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). APLNR/APJ receptor is also activated by mechanical strech in a G-protein-independent fashion to induce beta-arrestin signaling leading to cardiac hypertrophy (PubMed:22810587). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28663440, PubMed:28854362, PubMed:28890073). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure and heart contractility and protection from cardiac hypertrophy and heart failure (PubMed:22810587, PubMed:28371822)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZS9", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0060182 apelin receptor activity;GO:0140897 mechanoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WV08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CVB6-1", "uniprot_id": "ARPC2_MOUSE", "mass": 34357.0, "length": 300, "protein_name": "Actin-related protein 2/3 complex subunit 2", "gene_name": "Arpc2", "organism": "Mouse", "refseq_name": "actin-related protein 2/3 complex subunit 2 isoform 1", "refseq_ac": "NP_083987", "gene_names_uniprotkb": "Arpc2", "gene_names_refseq": "2210023N03Rik; 34kDa; Arpc2; p34-Arc", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC", "protein_names_refseq": "actin-related protein 2/3 complex subunit 2 isoform 1; arp2/3 complex 34 kDa subunit", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); silicosis (Disease Ontology:DOID:10325); melanoma (Disease Ontology:DOID:1909); invasive ductal carcinoma (Disease Ontology:DOID:3008); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:76709); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "21750661;24153177;25428506;28011936;30084848;30779550;32152506;33300544;34428180;37453647", "class_list": "", "function": "Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U870", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0061826 podosome ring;GO:0061834 actin filament branch point;GO:0061835 ventral surface of cell;GO:0005634 nucleus", "go_biological_process": "GO:0072752 cellular response to rapamycin;GO:2000814 positive regulation of barbed-end actin filament capping;GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CVB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0U9-1", "uniprot_id": "ARV1_MOUSE", "mass": 30535.0, "length": 266, "protein_name": "Protein ARV1", "gene_name": "Arv1", "organism": "Mouse", "refseq_name": "protein ARV1", "refseq_ac": "NP_081131", "gene_names_uniprotkb": "Arv1", "gene_names_refseq": "1110067L22Rik; Arv1", "protein_names_uniprotkb": "Protein ARV1", "protein_names_refseq": "protein ARV1", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 38 (Disease Ontology:DOID:0080417); lipid storage disease (Disease Ontology:DOID:9455)", "pathway": " (mmu:68865); (R-MMU-191273)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20663892;21750661;24273168;27270415;29491146", "class_list": "", "function": "Arv1-/- animals fed a high-fat diet were resistant to diet-induced obesity, had lower blood cholesterol and triglyceride levels, and retained glucose tolerance and insulin sensitivity., [RefSeq, PubMed]; Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism, [RefSeq, PubMed]; In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy, [RefSeq, PubMed]; Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes., [UniProtKB, UniProtKB, UniProtKB]; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892)., [UniProtKB, PubMed]; These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY08", "ec_number_list": "", "go_molecular_function": "GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D0U9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D668-1", "uniprot_id": "ARRD2_MOUSE", "mass": 44259.0, "length": 407, "protein_name": "Arrestin domain-containing protein 2", "gene_name": "Arrdc2", "organism": "Mouse", "refseq_name": "arrestin domain-containing protein 2", "refseq_ac": "NP_081836", "gene_names_uniprotkb": "Arrdc2", "gene_names_refseq": "4632416I05Rik; Arrdc2; Ilad1", "protein_names_uniprotkb": "Arrestin domain-containing protein 2", "protein_names_refseq": "arrestin domain-containing protein 2; induced by lysergic acid diethylamide-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38314723", "class_list": "", "function": "The mechanosensitive gene arrestin domain containing 2 regulates myotube diameter with direct implications for disuse atrophy with aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVK8;Q3UXC6", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0009612 response to mechanical stimulus;GO:0014902 myotube differentiation;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D668-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGV9-1", "uniprot_id": "ATG4D_MOUSE", "mass": 52910.0, "length": 474, "protein_name": "Cysteine protease ATG4D", "gene_name": "Atg4d", "organism": "Mouse", "refseq_name": "cysteine protease ATG4D precursor", "refseq_ac": "NP_705811", "gene_names_uniprotkb": "Atg4d; Apg4d; Autl4", "gene_names_refseq": "9830134P12Rik; APG4-D; Apg4d; Atg4dl; Atg4d; Autl4", "protein_names_uniprotkb": "Cysteine protease ATG4D; 3.4.22.-; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D", "protein_names_refseq": "APG4 (ATG4) autophagy-related homolog D; AUT-like 4, cysteine endopeptidase; autophagin-4; autophagy-related 4D; autophagy-related cysteine endopeptidase 4; autophagy-related protein 4 homolog D; cysteine protease ATG4D precursor; cysteine protease ATG4D; cysteine protease involved in autophagy APG4-D", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:235040); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12446702;21750661;21913724;31219806;33795848;33988247;35820727", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:33795848). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:33795848). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:33795848). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system (PubMed:33795848). Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins (PubMed:33795848). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4N9;Q8K0Q2", "ec_number_list": "3.4.22.-", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BGV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59384-1", "uniprot_id": "ATS15_MOUSE", "mass": 103938.0, "length": 950, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 15", "gene_name": "Adamts15", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 1 preproprotein", "refseq_ac": "NP_001019310", "gene_names_uniprotkb": "Adamts15", "gene_names_refseq": "Adamts15", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 15; 3.4.24.-; ADAM-TS 15; ADAM-TS15; ADAMTS-15", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform 1 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 15; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646)", "pathway": " (mmu:235130); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23233679;24220035;35962790", "class_list": "", "function": "Biallelic variants in ADAMTS15 cause a novel form of distal arthrogryposis. Erratum:[Genet Med. 2023 May;25(5):100799. doi: 10.1016/j.gim.2023.100799. PMID: 36853234], [RefSeq, PubMed]; Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1401-|-1402-Ala' site (PubMed:24220035). Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed:23233679)., [UniProtKB, PubMed, PubMed]; These data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican., [RefSeq, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active versicanase enzyme. This gene is located adjacent to a related ADAMTS gene (Adamts8) on chromosome 9. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q504Z2;Q91Z56", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P59384-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRA7-1", "uniprot_id": "ATP5S_MOUSE", "mass": 23275.0, "length": 200, "protein_name": "ATP synthase subunit s, mitochondrial", "gene_name": "Dmac2l", "organism": "Mouse", "refseq_name": "ATP synthase subunit s, mitochondrial precursor", "refseq_ac": "NP_080812", "gene_names_uniprotkb": "Dmac2l; Atp5s; Atpw", "gene_names_refseq": "1110015E18Rik; ATPW; Atp5s; Dmac2l", "protein_names_uniprotkb": "ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; Distal membrane arm assembly complex 2-like protein; Mitochondrial ATP synthase regulatory component factor B", "protein_names_refseq": "ATP synthase subunit s, mitochondrial precursor; ATP synthase subunit s, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit S; ATP synthase-coupling factor B; distal membrane arm assembly complex 2 like; distal membrane arm assembly complex 2-like protein; mitochondrial ATP synthase regulatory component factor B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68055); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2M3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CRA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4I1-1", "uniprot_id": "ATX7_MOUSE", "mass": 92697.0, "length": 867, "protein_name": "Ataxin-7", "gene_name": "Atxn7", "organism": "Mouse", "refseq_name": "ataxin-7 isoform 2", "refseq_ac": "NP_631973", "gene_names_uniprotkb": "Atxn7; Sca7", "gene_names_refseq": "A430107N12Rik; Atxn7; Sca7; ataxin-7", "protein_names_uniprotkb": "Ataxin-7; Spinocerebellar ataxia type 7 protein homolog", "protein_names_refseq": "ataxin-7 isoform 2; spinocerebellar ataxia 7 homolog; spinocerebellar ataxia type 7 protein homolog", "tax_id": 10090, "disease": "spinocerebellar ataxia 7 (Disease Ontology:DOID:0050958); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:246103); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11580893;12039035;21750661;23806337;36852467;40997131", "class_list": "", "function": "Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (By similarity). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Probably involved in tethering the deubiquitination module within the SAGA complex (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). Involved in neurodegeneration (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QPX9;Q8BL17", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R4I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2L1-1", "uniprot_id": "ARSK_MOUSE", "mass": 62801.0, "length": 553, "protein_name": "Arylsulfatase K", "gene_name": "Arsk", "organism": "Mouse", "refseq_name": "arylsulfatase K isoform 1 precursor", "refseq_ac": "NP_084123", "gene_names_uniprotkb": "Arsk", "gene_names_refseq": "2810429K17Rik; 4833414G15Rik; ASK; Arsk", "protein_names_uniprotkb": "Arylsulfatase K; 3.1.6.18; 3.1.6.1; ASK; Glucuronate-2-sulfatase", "protein_names_refseq": "arylsulfatase K isoform 1 precursor; glucuronate-2-sulfatase", "tax_id": 10090, "disease": "mucopolysaccharidosis X (Disease Ontology:DOID:0061128); mucopolysaccharidosis (Disease Ontology:DOID:12798)", "pathway": " (mmu:77041); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16174644;21750661;25428506;32856704;35820727", "class_list": "glycogene", "function": "Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate., [RefSeq, PubMed]; Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:32856704). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE11;Q8BL50;Q8BUA1;Q9CYZ0", "ec_number_list": "3.1.6.2;3.1.6.8;3.1.6.12;3.1.6.-;3.1.6.1;3.1.6.15;3.1.6.14;1.8.3.7;3.1.6.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0015024 glucuronate-2-sulfatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D2L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADU9-1", "uniprot_id": "AWAT1_MOUSE", "mass": 37573.0, "length": 328, "protein_name": "Acyl-CoA wax alcohol acyltransferase 1", "gene_name": "Awat1", "organism": "Mouse", "refseq_name": "acyl-CoA wax alcohol acyltransferase 1", "refseq_ac": "NP_001074605", "gene_names_uniprotkb": "Awat1; Dgat2l3", "gene_names_refseq": "Awat1; Dgat2l3", "protein_names_uniprotkb": "Acyl-CoA wax alcohol acyltransferase 1; 2.3.1.75; Diacylglycerol O-acyltransferase 2-like protein 3; Long-chain-alcohol O-fatty-acyltransferase 1", "protein_names_refseq": "acyl-CoA wax alcohol acyltransferase 1; diacylglycerol O-acyltransferase 2-like protein 3; long-chain-alcohol O-fatty-acyltransferase 1; wax synthase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245533); (R-MMU-2142753); (R-MMU-9640463)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23730681;34428180", "class_list": "", "function": "Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (By similarity). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (By similarity). Shows a strong preference for saturated acyl-CoAs (By similarity)., [UniProtKB, UniProtKB]; The highest activity was observed for 14:0-CoA, 12:0-CoA, and 16:0-CoA in combination with medium chain alcohols (up to 5.2, 3.4, and 3.3 nmol wax esters/min/mg microsomal protein, respectively, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW94", "ec_number_list": "2.3.1.-;2.3.1.75;2.3.1.20;2.3.1.76;2.3.1.22", "go_molecular_function": "GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2ADU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q769J6-1", "uniprot_id": "ATS13_MOUSE", "mass": 155357.0, "length": 1426, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "gene_name": "Adamts13", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein", "refseq_ac": "NP_001001322", "gene_names_uniprotkb": "Adamts13; Gm710", "gene_names_refseq": "ADAM-TS13; ADAMTS-13; Adamts13; Gm710; vWF-CP", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 13; 3.4.24.87; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease; von Willebrand factor-cleaving protease", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; vWF-CP mRNA for von Willebrand factor-cleaving; vWF-cleaving protease; von Willebrand factor-cleaving protease", "tax_id": 10090, "disease": "hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); HELLP syndrome (Disease Ontology:DOID:13133); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:279028); (R-MMU-5173214); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15136581;15806136;15869605;17426255;21750661;25428506;31219806;38597325", "class_list": "", "function": "ADAMTS13 deficiency exacerbates neuroinflammation by targeting matrix metalloproteinase-9 in ischemic brain injury., [RefSeq, PubMed]; Analysis of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease, [RefSeq, PubMed]; Characterization of the full-length murine ADAMTS13, [RefSeq, PubMed]; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation., [UniProtKB, PubMed]; Identification of the liver cell-type expressing ADAMTS13 will have is important for understanding pathophysiological mechanisms regulating ADAMTS13 expression., [RefSeq, PubMed]; The plasma ADAMTS13 activity levels of mouse strains segregated into a high and a low group. Low ADAMTS13 activity was detected in mice containing 2 alleles of intracisternal A-type particle (IAP) retrotransposon sequence, [RefSeq, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 15, "predicted_n_glycosites": 8, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "A2ALB4;Q76LW1", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0007596 blood coagulation;GO:0043171 peptide catabolic process;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q769J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03288-1", "uniprot_id": "ASIP_MOUSE", "mass": 14313.0, "length": 131, "protein_name": "Agouti-signaling protein", "gene_name": "Asip; a", "organism": "Mouse", "refseq_name": "agouti-signaling protein precursor", "refseq_ac": "NP_056585", "gene_names_uniprotkb": "Asip; a; a", "gene_names_refseq": "A; ASIP; ASP; As; a", "protein_names_uniprotkb": "Agouti-signaling protein; ASP; Agouti coat color protein; Agouti switch protein", "protein_names_refseq": "agouti coat color protein; agouti signal protein; agouti switch protein; agouti-signaling protein precursor; agouti-signaling protein; non-agouti", "tax_id": 10090, "disease": "pigmentation disease (Disease Ontology:DOID:10123); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:50518)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1473152;21750661;35283410;37371543;7935841;7987393;8202545;8319910;8449404", "class_list": "", "function": "Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Phylogeographic study using nuclear genome sequences of Asip to infer the origins of ventral fur color variation in the house mouse Mus musculus., [RefSeq, PubMed]; Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis (PubMed:7935841). Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis (PubMed:7935841, PubMed:8449404)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ALT3;Q80ST0", "ec_number_list": "", "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0005184 neuropeptide hormone activity;GO:0070996 type 1 melanocortin receptor binding;GO:0031779 melanocortin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0009755 hormone-mediated signaling pathway;GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03288-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AU72-1", "uniprot_id": "ARMC3_MOUSE", "mass": 97357.0, "length": 881, "protein_name": "Armadillo repeat-containing protein 3", "gene_name": "Armc3", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 3 isoform 1", "refseq_ac": "NP_001074552", "gene_names_uniprotkb": "Armc3", "gene_names_refseq": "4921513G22Rik; Armc3", "protein_names_uniprotkb": "Armadillo repeat-containing protein 3", "protein_names_refseq": "armadillo repeat-containing protein 3 isoform 1; armadillo repeat-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70882)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;21750661;34428398;39704931", "class_list": "", "function": "Armc3 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility., [RefSeq, PubMed]; Essential for male fertility and sperm motility. During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY67", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0034517 ribophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2AU72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H630-1", "uniprot_id": "ARMT1_MOUSE", "mass": 50549.0, "length": 439, "protein_name": "Damage-control phosphatase 1", "gene_name": "Armt1; Dcph1", "organism": "Mouse", "refseq_name": "damage-control phosphatase 1", "refseq_ac": "NP_077223", "gene_names_uniprotkb": "Armt1; Dcph1; 1700052N19Rik; Armt1", "gene_names_refseq": "1700052N19Rik; Armt1; Dcph1", "protein_names_uniprotkb": "Damage-control phosphatase 1; 2.1.1.-; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1", "protein_names_refseq": "UPF0364 protein C6orf211 homolog; acidic residue methyltransferase 1; damage-control phosphatase 1; damage-control phosphatase ARMT1; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73419)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;37507081;39927985", "class_list": "", "function": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499H1;Q99M05;Q9D9L4", "ec_number_list": "3.1.3.-;2.1.1.-;3.1.3.94;3.1.3.25", "go_molecular_function": "GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0051998 protein carboxyl O-methyltransferase activity;GO:0016791 phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A6H630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RY50-1", "uniprot_id": "ODAD2_MOUSE", "mass": 115266.0, "length": 1037, "protein_name": "Outer dynein arm-docking complex subunit 2", "gene_name": "Odad2", "organism": "Mouse", "refseq_name": "outer dynein arm-docking complex subunit 2", "refseq_ac": "NP_001344421", "gene_names_uniprotkb": "Odad2; Armc4", "gene_names_refseq": "4930463I21Rik; Armc4; Odad2; b2b227.1Clo; b2b643Clo", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 2; Armadillo repeat-containing protein 4", "protein_names_refseq": "armadillo repeat containing 4; armadillo repeat-containing protein 4; outer dynein arm-docking complex subunit 2", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 23 (Disease Ontology:DOID:0110609)", "pathway": " (mmu:74934)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17971504;21750661;23849778;24055424;34428180;35820727", "class_list": "", "function": "ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry., [RefSeq, PubMed]; Armc4 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (By similarity). Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:23849778)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUL6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0097546 ciliary base", "go_biological_process": "GO:0007507 heart development;GO:0007368 determination of left/right symmetry;GO:0021591 ventricular system development;GO:0003341 cilium movement;GO:0003356 regulation of cilium beat frequency", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RY50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0Y1-1", "uniprot_id": "ASIC5_MOUSE", "mass": 56523.0, "length": 495, "protein_name": "Bile acid-sensitive ion channel", "gene_name": "Asic5", "organism": "Mouse", "refseq_name": "bile acid-sensitive ion channel", "refseq_ac": "NP_067345", "gene_names_uniprotkb": "Asic5; Accn5", "gene_names_refseq": "Accn5; Asic5; BASIC; Blinac; Inac", "protein_names_uniprotkb": "Bile acid-sensitive ion channel; Acid-sensing ion channel subunit family member 5; Amiloride-sensitive cation channel 5; BASIC; BLINaC; Brain-liver-intestine amiloride-sensitive Na(+) channel", "protein_names_refseq": "acid-sensing (proton-gated) ion channel family member 5; acid-sensing ion channel 5; acid-sensing ion channel subunit family member 5; amiloride-sensitive Na+ channel; amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive sodium channel; bile acid-sensitive ion channel; brain-liver-intestine amiloride-sensitive Na(+) channel; brain-liver-intestine amiloride-sensitive sodium channel", "tax_id": 10090, "disease": "", "pathway": " (mmu:58170); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10457052;20656685;21750661;22735174;24663811;25360526;25428506;32034189;35820727", "class_list": "", "function": "Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum Publication Status: Online-Only, [RefSeq, PubMed]; Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:20656685, PubMed:22735174). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:20656685, PubMed:22735174). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (PubMed:20656685). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (PubMed:32034189)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; RBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity;GO:0015252 proton channel activity;GO:0160228 bile acid-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0035725 sodium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R0Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T21-1", "uniprot_id": "ATL4_MOUSE", "mass": 113225.0, "length": 1036, "protein_name": "ADAMTS-like protein 4", "gene_name": "Adamtsl4", "organism": "Mouse", "refseq_name": "ADAMTS-like protein 4 precursor", "refseq_ac": "NP_001288634", "gene_names_uniprotkb": "Adamtsl4; Tsrc1", "gene_names_refseq": "ADAMTSL-4; Adamtsl4; Tsrc1", "protein_names_uniprotkb": "ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1", "protein_names_refseq": "ADAMTS-like protein 4 precursor; ADAMTS-like protein 4; thrombospondin repeat containing 1; thrombospondin repeat protein 1; thrombospondin repeat-containing protein 1", "tax_id": 10090, "disease": "autosomal recessive isolated ectopia lentis 2 (Disease Ontology:DOID:0111149); ectopia lentis with ectopia of pupil (Disease Ontology:DOID:0111648); lens disease (Disease Ontology:DOID:110); craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (mmu:229595); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12706885;20637190;21750661;25428506;26405179;28011936", "class_list": "", "function": "O-fucose modification of thrombospondin type 1 repeats was essential for modulation of growth factor signaling during gastrulation., [RefSeq, PubMed]; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity)., [UniProtKB]; The first ADAMTSL4 mouse model, tvrm267, bearing a nonsense mutation in Adamtsl4, [RefSeq, PubMed]; The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q148X6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0002064 epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80T21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70158-1", "uniprot_id": "ASM3A_MOUSE", "mass": 49858.0, "length": 445, "protein_name": "Cyclic GMP-AMP phosphodiesterase SMPDL3A", "gene_name": "Smpdl3a", "organism": "Mouse", "refseq_name": "cyclic GMP-AMP phosphodiesterase SMPDL3A precursor", "refseq_ac": "NP_065586", "gene_names_uniprotkb": "Smpdl3a; Asml3a", "gene_names_refseq": "0610010C24Rik; ASM3A; ASML3A; ASML3; Smpdl3a", "protein_names_uniprotkb": "Cyclic GMP-AMP phosphodiesterase SMPDL3A; 2',3'-cGAMP phosphodiesterase SMPDL3A; 3.1.4.-; 3.6.1.15; ASM-like phosphodiesterase 3a; Acid sphingomyelinase-like phosphodiesterase 3a", "protein_names_refseq": "2',3'-cGAMP phosphodiesterase SMPDL3A; ASM-like phosphodiesterase 3a; acid sphingomyelinase-like phosphodiesterase 3a; cyclic GMP-AMP phosphodiesterase SMPDL3A precursor; cyclic GMP-AMP phosphodiesterase SMPDL3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:57319)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21750661;21913724;25288789;25428506;26095358;26495903;26792860;28011936;28935714;30899004;35984892;37890481", "class_list": "", "function": "Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA (By similarity). Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP (PubMed:26792860). Has in vitro activity with p-nitrophenyl-TMP (By similarity). Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates (By similarity). Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine (By similarity). Has in vitro activity with CDP-ethanolamine (By similarity). Does not have sphingomyelin phosphodiesterase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The structural basis for SMPDL3A substrate specificity resolve by X-ray crystallography., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8C2", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;3.6.1.6;3.6.1.42", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0008081 phosphoric diester hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0009143 nucleoside triphosphate catabolic process;GO:0160049 negative regulation of cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P70158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQP6-1", "uniprot_id": "ARRC_MOUSE", "mass": 41921.0, "length": 381, "protein_name": "Arrestin-C", "gene_name": "Arr3", "organism": "Mouse", "refseq_name": "arrestin-C", "refseq_ac": "NP_573468", "gene_names_uniprotkb": "Arr3", "gene_names_refseq": "Arr3; Arr4; Carfl; Carr; Car", "protein_names_uniprotkb": "Arrestin-C; Cone arrestin; Retinal cone arrestin-3; cArr", "protein_names_refseq": "X-arrestin; arrestin 4; arrestin-C; retinal cone arrestin-3", "tax_id": 10090, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:170735)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12135752;21750661;28151698", "class_list": "", "function": "May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0001664 G protein-coupled receptor binding;GO:0051219 phosphoprotein binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0045202 synapse;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007601 visual perception;GO:0002031 G protein-coupled receptor internalization;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98197-1", "uniprot_id": "AT11A_MOUSE", "mass": 135502.0, "length": 1187, "protein_name": "Phospholipid-transporting ATPase IH", "gene_name": "Atp11a", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase IH isoform 1", "refseq_ac": "NP_056619", "gene_names_uniprotkb": "Atp11a", "gene_names_refseq": "4930558F19Rik; Atp11a; Atpc1h; Ih", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A", "protein_names_refseq": "9130422H11Rik; ATPase 11A, class VI; ATPase 11A, p type; ATPase, class 1, member h; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-transporting ATPase IH isoform 1; probable phospholipid-transporting ATPase IH", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 24 (Disease Ontology:DOID:0070406); autosomal dominant nonsyndromic deafness 84 (Disease Ontology:DOID:0070604)", "pathway": " (mmu:50770); (R-MMU-6798695); (R-MMU-936837)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11015572;21750661;29799007;30018401;30084848;30779550;34403372;34428180;35820727;36300302", "class_list": "", "function": "A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2., [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (By similarity). Does not show flippase activity toward phosphatidylcholine (PC) (By similarity). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RS49", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;1.1.1.-;3.2.1.20;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0001701 in utero embryonic development;GO:0045332 phospholipid translocation;GO:0097035 regulation of membrane lipid distribution;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P98197-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEH3-1", "uniprot_id": "ARL8A_MOUSE", "mass": 21390.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 8A", "gene_name": "Arl8a", "organism": "Mouse", "refseq_name": "ADP-ribosylation factor-like protein 8A", "refseq_ac": "NP_081099", "gene_names_uniprotkb": "Arl8a; Arl10b; Gie2", "gene_names_refseq": "1110033P22Rik; Arl10b; Arl8a; gie2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8A; ADP-ribosylation factor-like protein 10B; Novel small G protein indispensable for equal chromosome segregation 2", "protein_names_refseq": "ADP-ribosylation factor-like 10B; ADP-ribosylation factor-like protein 10B; ADP-ribosylation factor-like protein 8A; novel small G protein indispensable for equal chromosome segregation 2; small G protein indispensable for equal chromosome segregation 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68724); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15331635;21750661;30174114;34428180", "class_list": "", "function": "Plays a role in lysosomes motility (PubMed:30174114). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114). May play a role in chromosome segregation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9848, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99KS1;Q9CTB0", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0051233 spindle midzone;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VEH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35085-1", "uniprot_id": "ARX_MOUSE", "mass": 58490.0, "length": 564, "protein_name": "Homeobox protein ARX", "gene_name": "Arx", "organism": "Mouse", "refseq_name": "homeobox protein ARX", "refseq_ac": "NP_001292869", "gene_names_uniprotkb": "Arx", "gene_names_refseq": "Arx1; Arx", "protein_names_uniprotkb": "Homeobox protein ARX; Aristaless-related homeobox", "protein_names_refseq": "homeobox protein ARX", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); developmental and epileptic encephalopathy 1 (Disease Ontology:DOID:0080468); non-syndromic X-linked intellectual disability ARX-related (Disease Ontology:DOID:0112021); corpus callosum agenesis-abnormal genitalia syndrome (Disease Ontology:DOID:0112151); X-linked lissencephaly 2 (Disease Ontology:DOID:0112238); Partington syndrome (Disease Ontology:DOID:14744); epilepsy (Disease Ontology:DOID:1826); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11878)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12379852;14561778;15930104;22387004;22570716;31219806;31691806;9256348", "class_list": "", "function": "DNA-binding transcription factor that plays a central role in the differentiation and development of type A pancreatic cells, which are located in the islets of Langerhans and secrete glucagon (PubMed:14561778, PubMed:15930104). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes (By similarity). Also plays a key role in intestinal enteroendocrine cell differentiation by promoting differentiation of intestinal enteroendocrine cell types L, -N, -D, -I and -G (PubMed:22387004, PubMed:22570716). Required for normal brain development: plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (PubMed:12379852, PubMed:31691806). May also be involved in axonal guidance in the floor plate (PubMed:9256348). Promotes expression of transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a transcription factor that plays an important role in the development of forebrain. Male mice lacking this gene have smaller brains, olfactory bulbs and testes, and die within half a day after birth. Mice lacking this gene specifically in ganglionic eminence-derived neurons, including cortical interneurons, develop seizures. Mutations in this gene have been demonstrated to cause mouse phenotypes resembling human X-linked lissencephaly and cognitive disability with epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4G9;Q9QYT4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16951-1", "uniprot_id": "ATF2_MOUSE", "mass": 52298.0, "length": 487, "protein_name": "Cyclic AMP-dependent transcription factor ATF-2", "gene_name": "Atf2", "organism": "Mouse", "refseq_name": "cyclic AMP-dependent transcription factor ATF-2 isoform 1", "refseq_ac": "NP_001020264", "gene_names_uniprotkb": "Atf2", "gene_names_refseq": "Atf-2; Atf2; CRE-BP; Creb2; D130078H02Rik; Tg(Gzma-Klra1)7Wum; mXBP", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-2; Activating transcription factor 2; MXBP protein; cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2", "protein_names_refseq": "cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2; cyclic AMP-dependent transcription factor ATF-2 isoform 1; cyclic AMP-dependent transcription factor ATF-2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); meconium aspiration syndrome (Disease Ontology:DOID:11049); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); osteochondrodysplasia (Disease Ontology:DOID:2256); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:11909); (R-MMU-3214847); (R-MMU-450341)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11471062;1531087;17242355;21183079;2138707;21750661;22517741;29237092;32782141;35822049;35855866;36809837;36852467;37973625;40411666;40885482;9524124", "class_list": "", "function": "LncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion Oxidative Stress Injury through Regulating ATF2 by Sponging miR-203. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of ATF2 promotes odontoblastic differentiation via intrinsic HAT activity., [RefSeq, PubMed]; The P38MAPK/ATF2 signaling pathway is involved in PND in mice., [RefSeq, PubMed]; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64089;Q64090;Q64091", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0003360 brainstem development;GO:0021754 facial nucleus development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P16951-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50289-1", "uniprot_id": "ASPX_MOUSE", "mass": 27948.0, "length": 261, "protein_name": "Acrosomal protein SP-10", "gene_name": "Acrv1", "organism": "Mouse", "refseq_name": "acrosomal protein SP-10 isoform 1 precursor", "refseq_ac": "NP_031417", "gene_names_uniprotkb": "Acrv1", "gene_names_refseq": "Acrv1; Msa63; SP-10", "protein_names_uniprotkb": "Acrosomal protein SP-10; Acrosomal vesicle protein 1; MSA-63", "protein_names_refseq": "MSA-63; acrosomal protein SP-10 isoform 1 precursor; acrosomal protein SP-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:11451)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1591350;36793255;8547483", "class_list": "", "function": "Transcriptional regulation of spatiotemporal gene expression within the seminiferous epithelium: Mouse Acrv1 gene as a model. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RT20;Q9DAM6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0031982 vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50992-1", "uniprot_id": "ATP4B_MOUSE", "mass": 33566.0, "length": 294, "protein_name": "Potassium-transporting ATPase subunit beta", "gene_name": "Atp4b", "organism": "Mouse", "refseq_name": "potassium-transporting ATPase subunit beta", "refseq_ac": "NP_033854", "gene_names_uniprotkb": "Atp4b", "gene_names_refseq": "Atp4b", "protein_names_uniprotkb": "Potassium-transporting ATPase subunit beta; Gastric H(+)/K(+) ATPase subunit beta; Proton pump beta chain", "protein_names_refseq": "ATPase, H+/K+ transporting, beta polypeptide, gastric specific; H+,K+-ATPase; H+/K+-ATPase beta; H,K-ATPase-Beta; gastric H(+)/K(+) ATPase subunit beta; potassium-transporting ATPase subunit beta; proton pump beta chain", "tax_id": 10090, "disease": "autoimmune gastritis (Disease Ontology:DOID:0040090); stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); atrophic gastritis (Disease Ontology:DOID:8929); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11945); (R-MMU-936837)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10700469;10764766;1370459;1654563", "class_list": "", "function": "The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6S3;Q9D6T2;Q9D6Y2", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity;GO:0008900 P-type potassium:proton transporter activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0010155 regulation of proton transport;GO:0007155 cell adhesion;GO:0032496 response to lipopolysaccharide;GO:0009101 glycoprotein biosynthetic process;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61161-1", "uniprot_id": "ARP2_MOUSE", "mass": 44761.0, "length": 394, "protein_name": "Actin-related protein 2", "gene_name": "Actr2", "organism": "Mouse", "refseq_name": "actin-related protein 2 isoform 2", "refseq_ac": "NP_666355", "gene_names_uniprotkb": "Actr2; Arp2", "gene_names_refseq": "4921510D23Rik; Actr2; Arp2; D6Ertd746e", "protein_names_uniprotkb": "Actin-related protein 2; Actin-like protein 2", "protein_names_refseq": "ARP2 actin-related protein 2 homolog; actin-like protein 2; actin-related protein 2 isoform 2", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung disease (Disease Ontology:DOID:850)", "pathway": " (mmu:66713); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213); (R-MMU-6798695); (R-MMU-8856828)", "pathway_count": 6, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;11465105;12589062;15085951;15233919;18299400;19224205;20173027;20484733;20693329;21952136;22872234;25428506;25605945;26495903;28011936;30084848;30779550;31219806;31961823;32079655;32152506;33300544;33649389;33903241;34203471;34428180;35658973;35820727;35984892;36210013;37453647;37507081;37828378", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification., [RefSeq, PubMed]; Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Publication Status: Online-Only, [RefSeq, PubMed]; Arp2/3 inhibition in growth cones doesn't affect actin organization or inhibit lamellipodia protrusion or filopodia formation. Arp2/3 inhibition enhances axon elongation and causes defects in growth cone guidance., [RefSeq, PubMed]; Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic beta cells to control insulin secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial cell invasion is controlled by dactylopodia., [RefSeq, PubMed]; N-WASP and the Arp2/3 complex trigger actin polymerization during a late step in clathrin-mediated endocytosis, [RefSeq, PubMed]; Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O15142;Q6PI31", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0060271 cilium assembly;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P61161-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04646-1", "uniprot_id": "ATNG_MOUSE", "mass": 7520.0, "length": 70, "protein_name": "Sodium/potassium-transporting ATPase subunit gamma", "gene_name": "Fxyd2", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit gamma isoform a", "refseq_ac": "NP_031529", "gene_names_uniprotkb": "Fxyd2; Atp1c; Atp1g1", "gene_names_refseq": "Atp1g1; Fxyd2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Na(+)/K(+) ATPase subunit gamma; Sodium pump gamma chain", "protein_names_refseq": "ATPase, Na+/K+ transporting, gamma 1 polypeptide; Na(+)/K(+) ATPase subunit gamma; sodium pump gamma chain; sodium/potassium-transporting ATPase gamma chain; sodium/potassium-transporting ATPase subunit gamma isoform a; sodium/potassium-transporting ATPase subunit gamma", "tax_id": 10090, "disease": "renal hypomagnesemia 2 (Disease Ontology:DOID:0060885)", "pathway": " (mmu:11936); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11526196;21750661;25633594;38688414;8387529", "class_list": "", "function": "FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation., [RefSeq, PubMed]; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression., [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923I2;Q923I3;Q923I4", "ec_number_list": "", "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:2000649 regulation of sodium ion transmembrane transporter activity;GO:0006812 monoatomic cation transport;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3USF0-1", "uniprot_id": "B3GN6_MOUSE", "mass": 43951.0, "length": 391, "protein_name": "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase", "gene_name": "B3gnt6", "organism": "Mouse", "refseq_name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase", "refseq_ac": "NP_001074636", "gene_names_uniprotkb": "B3gnt6", "gene_names_refseq": "B3gnt6; Core-3; Core3", "protein_names_uniprotkb": "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; 2.4.1.147; BGnT-6; Beta-1,3-Gn-T6; Beta-1,3-N-acetylglucosaminyltransferase 6; Beta3Gn-T6; Core 3 synthase; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6", "protein_names_refseq": "BGnT-6; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; beta-1,3-Gn-T6; beta-1,3-N-acetylglucosaminyltransferase 6; beta3Gn-T6; core 3 synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:272411); (R-MMU-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.149;2.4.1.147;2.4.1.146;2.4.1.206", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008378 galactosyltransferase activity;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047224 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 897, "hit_score": 0.1, "record_id": "Q3USF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497K5-1", "uniprot_id": "ARRD5_MOUSE", "mass": 36788.0, "length": 325, "protein_name": "Arrestin domain-containing protein 5", "gene_name": "Arrdc5", "organism": "Mouse", "refseq_name": "arrestin domain-containing protein 5", "refseq_ac": "NP_084075", "gene_names_uniprotkb": "Arrdc5", "gene_names_refseq": "1700013E09Rik; Arrdc5", "protein_names_uniprotkb": "Arrestin domain-containing protein 5", "protein_names_refseq": "arrestin domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76920)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;36210013;37069147;37997706", "class_list": "", "function": "ARRDC5 deficiency impairs spermatogenesis by affecting SUN5 and NDC1., [RefSeq, PubMed]; ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role in spermatogenesis (PubMed:37069147, PubMed:37997706). May be involved in the anchoring of the sperm head to the tail during spermatogenesis by affecting SEC22A-mediated SUN5 and NDC1 transport and localization (PubMed:37997706)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q497K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XF89-1", "uniprot_id": "AT133_MOUSE", "mass": 137469.0, "length": 1219, "protein_name": "Polyamine-transporting ATPase 13A3", "gene_name": "Atp13a3", "organism": "Mouse", "refseq_name": "polyamine-transporting ATPase 13A3 isoform 2", "refseq_ac": "NP_001121566", "gene_names_uniprotkb": "Atp13a3; Gm542", "gene_names_refseq": "Atp13a3; Gm1745; Gm541; Gm542", "protein_names_uniprotkb": "Polyamine-transporting ATPase 13A3; 7.6.2.16; Putrescine transporting ATPase", "protein_names_refseq": "polyamine-transporting ATPase 13A3 isoform 2; polyamine-transporting ATPase 13A3; probable cation-transporting ATPase 13A3; putrescine transporting ATPase; type V P-type ATPase", "tax_id": 10090, "disease": "Kufor-Rakeb syndrome (Disease Ontology:DOID:0060556); juvenile-onset Parkinson's disease (Disease Ontology:DOID:0060893); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); primary pulmonary hypertension (Disease Ontology:DOID:14557); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (mmu:224088)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15381061;19144319;21183079;21750661;25428506;26495903;30084848;31599954;34428180;38626311", "class_list": "", "function": "ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol., [UniProtKB, UniProtKB]; ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:1902047 polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5XF89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q641P0-1", "uniprot_id": "ARP3B_MOUSE", "mass": 47580.0, "length": 418, "protein_name": "Actin-related protein 3B", "gene_name": "Actr3b", "organism": "Mouse", "refseq_name": "actin-related protein 3B isoform 1", "refseq_ac": "NP_001004365", "gene_names_uniprotkb": "Actr3b", "gene_names_refseq": "9630005C02; ARP11; Actr3b; Arp3beta; Arp3b", "protein_names_uniprotkb": "Actin-related protein 3B; ARP3-beta; Actin-like protein 3B", "protein_names_refseq": "ARP3 actin-related protein 3 homolog B; actin-related protein 3-beta; actin-related protein 3B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242894)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;30084848;30779550;33300544;34428180", "class_list": "", "function": "Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSH1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q641P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64436-1", "uniprot_id": "ATP4A_MOUSE", "mass": 114065.0, "length": 1034, "protein_name": "Potassium-transporting ATPase alpha chain 1", "gene_name": "Atp4a", "organism": "Mouse", "refseq_name": "potassium-transporting ATPase alpha chain 1 isoform 1", "refseq_ac": "NP_001277556", "gene_names_uniprotkb": "Atp4a", "gene_names_refseq": "Atp4a", "protein_names_uniprotkb": "Potassium-transporting ATPase alpha chain 1; 7.2.2.19; Gastric H(+)/K(+) ATPase subunit alpha; Proton pump", "protein_names_refseq": "ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; H+/K+-ATPase alpha; H+K+-transporting alpha 1; gastric H(+)/K(+) ATPase subunit alpha; potassium-transporting ATPase alpha chain 1 isoform 1; potassium-transporting ATPase alpha chain 1; proton pump", "tax_id": 10090, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:11944); (R-MMU-936837)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10764766;21750661;22645316;30084848;35820727;7762614", "class_list": "", "function": "The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells (PubMed:7762614). Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (PubMed:7762614). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (PubMed:10764766). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity) (PubMed:7762614)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNX7;Q9CV46", "ec_number_list": "7.2.2.19;7.2.2.13", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030955 potassium ion binding;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010155 regulation of proton transport;GO:0006883 intracellular sodium ion homeostasis;GO:0009410 response to xenobiotic stimulus;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSK7-1", "uniprot_id": "ATL2_MOUSE", "mass": 105647.0, "length": 957, "protein_name": "ADAMTS-like protein 2", "gene_name": "Adamtsl2", "organism": "Mouse", "refseq_name": "ADAMTS-like protein 2 precursor", "refseq_ac": "NP_084257", "gene_names_uniprotkb": "Adamtsl2; Kiaa0605; Tcp1", "gene_names_refseq": "A930008K15Rik; Adamtsl2; tcp-1", "protein_names_uniprotkb": "ADAMTS-like protein 2; ADAMTSL-2; TCP-1; TSP1-repeat-containing protein 1", "protein_names_refseq": "ADAMTS-like protein 2 precursor; ADAMTS-like protein 2; TSP1-repeat-containing protein 1; TSP1-repeats-containing protein 1", "tax_id": 10090, "disease": "geleophysic dysplasia 1 (Disease Ontology:DOID:0111725); impotence (Disease Ontology:DOID:1875)", "pathway": " (mmu:77794); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17509843;25762570;30084848;30303737;32913123;34428180;34611183;37187448;37656189", "class_list": "", "function": "A nonsense mutation in mouse Adamtsl2 causes uterine hypoplasia and an irregular estrous cycle., [RefSeq, PubMed]; Adamtsl2 deficiency is associated with Impairment of chondrogenesis and microfibrillar network., [RefSeq, PubMed]; Data suggest that induction of Adamtsl2 mRNA is an integral feature of myogenesis., [RefSeq, PubMed]; O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations., [RefSeq, PubMed]; Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling., [RefSeq, PubMed]; The bronchial epithelial dysplasia accompanying microfibril dysregulation in Adamtsl2(-/-) mice cannot be reversed by TGFbeta neutralization, and thus might be mediated by other mechanisms., [RefSeq, PubMed]; The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFbeta signalling in cardiac fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0C8", "ec_number_list": "", "go_molecular_function": "GO:0050436 microfibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060481 lobar bronchus epithelium development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TSK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X86-1", "uniprot_id": "ARM12_MOUSE", "mass": 38530.0, "length": 340, "protein_name": "Armadillo repeat-containing protein 12", "gene_name": "Armc12", "organism": "Mouse", "refseq_name": "armadillo repeat-containing protein 12", "refseq_ac": "NP_080566", "gene_names_uniprotkb": "Armc12", "gene_names_refseq": "4930511I11Rik; Armc12", "protein_names_uniprotkb": "Armadillo repeat-containing protein 12", "protein_names_refseq": "armadillo repeat-containing protein 12; testis specific expressed protein 3", "tax_id": 10090, "disease": "spermatogenic failure 90 (Disease Ontology:DOID:0070589)", "pathway": " (mmu:67645)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30026490;33536340;35534203", "class_list": "", "function": "ARMC12 promotes neuroblastoma progression through interaction with RBBP4. Publication Status: Online-Only, [RefSeq, PubMed]; ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility., [RefSeq, PubMed]; Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice., [RefSeq, PubMed]; Essential for male fertility and sperm mitochondrial sheath formation (PubMed:33536340, PubMed:35534203). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (PubMed:33536340). Facilitates the growth and aggressiveness of neuroblastoma cells (By similarity). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D564;Q9DAN7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030317 flagellated sperm motility;GO:0120317 sperm mitochondrial sheath assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80X86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHT6-1", "uniprot_id": "B3GLT_MOUSE", "mass": 55358.0, "length": 489, "protein_name": "Beta-1,3-glucosyltransferase", "gene_name": "B3glct", "organism": "Mouse", "refseq_name": "beta-1,3-glucosyltransferase precursor", "refseq_ac": "NP_001074673", "gene_names_uniprotkb": "B3glct; B3galtl; Gm1057", "gene_names_refseq": "B3galtl; B3glct; Gm1057; beta3Glc-T", "protein_names_uniprotkb": "Beta-1,3-glucosyltransferase; 2.4.1.-; Beta 3-glucosyltransferase; Beta-3-glycosyltransferase-like; Beta3Glc-T", "protein_names_refseq": "beta 1,3-galactosyltransferase-like; beta-1,3-glucosyltransferase precursor; beta-1,3-glucosyltransferase; beta-3-glycosyltransferase-like", "tax_id": 10090, "disease": "Peters plus syndrome (Disease Ontology:DOID:0080201)", "pathway": " (mmu:381694); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16899492;25428506;30899004;31600785;33909046", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-glucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological processes. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. It starts with POFUT2, which attaches fucose via an O-glycosidic bond to a conserved serine or threonine residue. B3GLCT extends this modification by transferring a glucose molecule from UDP-glucose to the fucose., [UniProtKB, UniProtKB]; Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ., [RefSeq, PubMed]; Results provide compelling evidence that ADAMTS9 and ADAMTS20 were differentially sensitive to B3GLCT inactivation and suggest that the developmental defects in PTRPLS result from disruption of a subset of highly sensitive POFUT2/B3GLCT targets such as ADAMTS20. Erratum:[Hum Mol Genet. 2020 Oct 10;29(17):2986-2987. doi: 10.1093/hmg/ddaa090. PMID: 32533185], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QMK8;Q0PCR7;Q149S5", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14", "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0160265 O-fucosylpeptide 3-beta-glucosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0001501 skeletal system development;GO:0007420 brain development;GO:0060271 cilium assembly;GO:0060021 roof of mouth development", "synthesized_glycan_count": 6, "hit_score": 1.4, "record_id": "Q8BHT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM89-1", "uniprot_id": "ARSJ_MOUSE", "mass": 67354.0, "length": 598, "protein_name": "Arylsulfatase J", "gene_name": "Arsj", "organism": "Mouse", "refseq_name": "arylsulfatase J precursor", "refseq_ac": "NP_775627", "gene_names_uniprotkb": "Arsj", "gene_names_refseq": "9330196J05Rik; Arsj; D830047F08", "protein_names_uniprotkb": "Arylsulfatase J; 3.1.6.-; ASJ", "protein_names_refseq": "ASJ; arylsulfatase J precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:271970); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKG5;Q8BL46", "ec_number_list": "3.1.6.2;3.1.6.8;3.1.6.12;3.1.6.-;3.1.6.1;3.1.6.15;1.8.3.7;3.1.6.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0015629 actin cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BM89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9W3-1", "uniprot_id": "ATS2_MOUSE", "mass": 135299.0, "length": 1213, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "gene_name": "Adamts2", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein", "refseq_ac": "NP_783574", "gene_names_uniprotkb": "Adamts2", "gene_names_refseq": "ADAM-TS 2; ADAM-TS2; ADAMTS-2; Adamts2; PC I-NP; PCINP; pNPI", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 2; 3.4.24.14; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; Procollagen I N-proteinase; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; procollagen I/II amino propeptide-processing enzyme; procollagen N-endopeptidase; procollagen N-proteinase", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Ehlers-Danlos syndrome dermatosparaxis type (Disease Ontology:DOID:0080733); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (mmu:216725); (R-MMU-1650814); (R-MMU-5173214)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17929299;21750661;31599954;37929635;38871984", "class_list": "", "function": "ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex., [RefSeq, PubMed]; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function., [RefSeq, PubMed]; The extent of liver fibrosis is reduced in ADAMTS2-deficient mice in comparison with their wild type littermates., [RefSeq, PubMed]; This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.4.24.19;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C9W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2X1-1", "uniprot_id": "AT10D_MOUSE", "mass": 158330.0, "length": 1416, "protein_name": "Phospholipid-transporting ATPase VD", "gene_name": "Atp10d", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase VD", "refseq_ac": "NP_700438", "gene_names_uniprotkb": "Atp10d", "gene_names_refseq": "9830145H18Rik; ATPVD; Atp10d; D5Buc24e", "protein_names_uniprotkb": "Phospholipid-transporting ATPase VD; 7.6.2.1; ATPase class V type 10D; P4-ATPase flippase complex alpha subunit ATP10D", "protein_names_refseq": "P4-ATPase flippase complex alpha subunit ATP10D; phospholipid-transporting ATPase VD; probable phospholipid-transporting ATPase VD; putative type IV aminophospholipid transporting ATPase", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:231287); (R-MMU-936837)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12532265;25428507;26495903;30018401;31219806", "class_list": "", "function": "Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane., [UniProtKB, UniProtKB]; The involvement of the Atp10d gene in the fat-prone phenotype of the C57BL/6 strain and its physical mapping within a QTL associated with HDL-cholesterol levels, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity;GO:0140351 glycosylceramide flippase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K2X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922M7-1", "uniprot_id": "ASHWN_MOUSE", "mass": 26031.0, "length": 232, "protein_name": "tRNA-splicing ligase complex subunit ASW", "gene_name": "AI597479", "organism": "Mouse", "refseq_name": "tRNA-splicing ligase complex subunit ASW", "refseq_ac": "NP_598579", "gene_names_uniprotkb": "AI597479", "gene_names_refseq": "AI597479", "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit ASW", "protein_names_refseq": "ashwin; tRNA-splicing ligase complex subunit ASW", "tax_id": 10090, "disease": "", "pathway": " (mmu:98404)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;31599954", "class_list": "", "function": "Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity and may function toward other RNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q922M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LS0-1", "uniprot_id": "AUGN_MOUSE", "mass": 16992.0, "length": 148, "protein_name": "Augurin", "gene_name": "Ecrg4", "organism": "Mouse", "refseq_name": "augurin precursor", "refseq_ac": "NP_077245", "gene_names_uniprotkb": "Ecrg4", "gene_names_refseq": "1500015O10Rik; Ecrg4", "protein_names_uniprotkb": "Augurin; Esophageal cancer-related gene 4 protein homolog", "protein_names_refseq": "augurin precursor; augurin; esophageal cancer related gene 4 protein; esophageal cancer-related gene 4 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78896)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17284679;19735703;20404145;21349154", "class_list": "", "function": "ECRG4 level in differentiated chondrocytes is decreased during hypertrophic maturation, [RefSeq, PubMed]; Identified esophageal cancer-related gene 4 (Ecrg4) as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain., [RefSeq, PubMed]; Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2U7", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0031045 dense core granule", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99LS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ME6-1", "uniprot_id": "AT1B4_MOUSE", "mass": 41401.0, "length": 356, "protein_name": "Protein ATP1B4", "gene_name": "Atp1b4", "organism": "Mouse", "refseq_name": "protein ATP1B4 isoform 2", "refseq_ac": "NP_001277318", "gene_names_uniprotkb": "Atp1b4", "gene_names_refseq": "1110020B02Rik; Atp1b4", "protein_names_uniprotkb": "Protein ATP1B4; X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m", "protein_names_refseq": "ATPase, (Na+)/K+ transporting, beta 4 polypeptide; protein ATP1B4 isoform 2; protein ATP1B4; x,K-ATPase subunit beta-m; x/potassium-transporting ATPase subunit beta-m", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:67821); (R-MMU-2173795)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14656723;17592128", "class_list": "", "function": "During evolution, ATP1B4 lost its ancestral function, accumulated in nuclear membrane of perinatal myocytes, and associates with transcriptional coregulator Ski-interacting protein (SKIP)., [RefSeq, PubMed]; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity)., [UniProtKB]; Primary structure was determined and developmental regulation of the gene (ATP1B4) was analyzed, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543D0;Q99ME5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0000785 chromatin;GO:0005637 nuclear inner membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99ME6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR84-1", "uniprot_id": "AT5G1_MOUSE", "mass": 14200.0, "length": 136, "protein_name": "ATP synthase F(0) complex subunit C1, mitochondrial", "gene_name": "Atp5mc1", "organism": "Mouse", "refseq_name": "ATP synthase F(0) complex subunit C1, mitochondrial", "refseq_ac": "NP_001154891", "gene_names_uniprotkb": "Atp5mc1; Atp5g1", "gene_names_refseq": "Atp5g1; Atp5mc1", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1; ATP synthase proteolipid P1; ATPase protein 9; ATPase subunit c; Proton-conducting channel, ATP synthase F(0) complex subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); ATPase protein 9; ATPase subunit c; proton-conducting channel, ATP synthase F(0) complex subunit c", "tax_id": 10090, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143)", "pathway": " (mmu:11951); (R-MMU-163210); (R-MMU-8949613)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "28011936;30530489;31219806;34428180", "class_list": "", "function": "Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIE9", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0015252 proton channel activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043025 neuronal cell body;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0045471 response to ethanol;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0A3-1", "uniprot_id": "ARPIN_MOUSE", "mass": 25193.0, "length": 226, "protein_name": "Arpin", "gene_name": "Arpin", "organism": "Mouse", "refseq_name": "arpin", "refseq_ac": "NP_081696", "gene_names_uniprotkb": "Arpin", "gene_names_refseq": "2610034B18Rik; Arpin", "protein_names_uniprotkb": "Arpin; Arp2/3 inhibition protein", "protein_names_refseq": "UPF0552 protein C15orf38 homolog; arp2/3 inhibition protein; arpin", "tax_id": 10090, "disease": "", "pathway": " (mmu:70420)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24132237;28135057;28528544;35820727", "class_list": "", "function": "Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1F3;Q8CA84", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030027 lamellipodium", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030336 negative regulation of cell migration;GO:0051017 actin filament bundle assembly;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D0A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAP7-1", "uniprot_id": "ASF1B_MOUSE", "mass": 22464.0, "length": 202, "protein_name": "Histone chaperone ASF1B", "gene_name": "Asf1b", "organism": "Mouse", "refseq_name": "histone chaperone ASF1B", "refseq_ac": "NP_077146", "gene_names_uniprotkb": "Asf1b", "gene_names_refseq": "1700003K02Rik; Asf1b; CIA-II", "protein_names_uniprotkb": "Histone chaperone ASF1B; Anti-silencing function protein 1 homolog B; CCG1-interacting factor A-II; CIA-II; mCIA-II", "protein_names_refseq": "ASF1 anti-silencing function 1 homolog B; CCG1-interacting factor A-II; anti-silencing function protein 1 homolog B; histone chaperone ASF1B; mCIA-II", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:66929)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12842904;17054786;20021694;25428506;26850882;30084848;34906203", "class_list": "", "function": "Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:12842904, PubMed:17054786). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (By similarity). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5ac and H4K12ac) marks in the cytosol (By similarity). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Required for gonad development (PubMed:26850882)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Loss of the histone chaperone ASF1B reduces female reproductive capacity., [RefSeq, PubMed]; Tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP41;Q9CTX3", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DAP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPE9-1", "uniprot_id": "AT131_MOUSE", "mass": 132388.0, "length": 1200, "protein_name": "Endoplasmic reticulum transmembrane helix translocase", "gene_name": "Atp13a1", "organism": "Mouse", "refseq_name": "endoplasmic reticulum transmembrane helix translocase", "refseq_ac": "NP_573487", "gene_names_uniprotkb": "Atp13a1; Atp13a", "gene_names_refseq": "Atp13a1; Atp13a; Cgi152; catp", "protein_names_uniprotkb": "Endoplasmic reticulum transmembrane helix translocase; 7.4.2.-; Endoplasmic reticulum P5A-ATPase", "protein_names_refseq": "cation-transporting ATPase 2; endoplasmic reticulum P5A-ATPase; endoplasmic reticulum transmembrane helix translocase; manganese-transporting ATPase 13A1; probable cation-transporting ATPase 13A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170759); (R-MMU-936837)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21183079;21750661;25428506;26848562;29407413;29505581;31219806;34428180;35820727;36210013;36216581", "class_list": "", "function": "Double mutant mice with loss of Atp13a2 function combined with overexpression of human wildtype aSyn showed an earlier onset and accelerated alterations in sensorimotor function that were age, sex and test-dependent. Female 13a2-aSyn mice showed early and progressive dysfunction on the beam and in locomotor activity. In males, 13a2-aSyn mice showed more severe impairments in spontaneous activity and adhesive removal., [RefSeq, PubMed]; Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains., [UniProtKB, UniProtKB]; The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity., [RefSeq, PubMed]; This study revealed a novel role of ATP13A2 in modulating astrocyte-mediated neuroinflammation via NLRP3 inflammasome activation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RS54", "ec_number_list": "7.4.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0140569 extraction of mislocalized protein from ER membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EPE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV27-1", "uniprot_id": "AT1A4_MOUSE", "mass": 114887.0, "length": 1032, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-4", "gene_name": "Atp1a4", "organism": "Mouse", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-4", "refseq_ac": "NP_038762", "gene_names_uniprotkb": "Atp1a4; Atp1al2", "gene_names_refseq": "Atp1a4", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-4; 7.2.2.13; Na(+)/K(+) ATPase alpha-4 subunit; Sodium pump subunit alpha-4", "protein_names_refseq": "Na(+)/K(+) ATPase alpha-4 subunit; Na+/K+ ATPase alpha 4 subunit; sodium pump subunit alpha-4; sodium/potassium-transporting ATPase alpha-4 chain; sodium/potassium-transporting ATPase subunit alpha-4", "tax_id": 10090, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:27222); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10555956;21187400;33977467;34428180", "class_list": "", "function": "Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape., [RefSeq, PubMed]; Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (By similarity). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (PubMed:21187400)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKL5;Q9R173;Q9WV28", "ec_number_list": "7.2.2.13;7.2.2.19", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005886 plasma membrane;GO:0042995 cell projection;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0042391 regulation of membrane potential;GO:0030317 flagellated sperm motility;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WV27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1W8-1", "uniprot_id": "AT12A_MOUSE", "mass": 114727.0, "length": 1035, "protein_name": "Potassium-transporting ATPase alpha chain 2", "gene_name": "Atp12a", "organism": "Mouse", "refseq_name": "potassium-transporting ATPase alpha chain 2", "refseq_ac": "NP_619593", "gene_names_uniprotkb": "Atp12a; Atp1al1", "gene_names_refseq": "Atp12a; Atp1al1; HKalpha2; cHKA", "protein_names_uniprotkb": "Potassium-transporting ATPase alpha chain 2; 7.2.2.13; 7.2.2.19; HK alpha 2; Non-gastric H(+)/K(+) ATPase subunit alpha; Non-gastric Na(+)/K(+) ATPase subunit alpha; Proton pump; Sodium pump", "protein_names_refseq": "ATPase H+K+-transporting, alpha 2; HK alpha 2; non-gastric H(+)/K(+) ATPase subunit alpha; non-gastric Na(+)/K(+) ATPase subunit alpha; potassium-transporting ATPase alpha chain 2; proton pump; sodium pump", "tax_id": 10090, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); epilepsy (Disease Ontology:DOID:1826); hypokalemia (Disease Ontology:DOID:4500); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:192113); (R-MMU-936837)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11729223;30084848;31913688;9449685;9872395", "class_list": "", "function": "H,K-ATPase type 2 regulates renal salt and potassium metabolism during gestation, controlling plasma volume expansion and blood pressure., [RefSeq, PubMed]; The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (By similarity). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (PubMed:9449685). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32MR8;Q8VHY2", "ec_number_list": "7.2.2.19;7.2.2.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0008900 P-type potassium:proton transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0055075 potassium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z1W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35451-1", "uniprot_id": "ATF6B_MOUSE", "mass": 76007.0, "length": 699, "protein_name": "Cyclic AMP-dependent transcription factor ATF-6 beta", "gene_name": "Atf6b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Atf6b; Crebl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-6 beta; ATF6-beta; Activating transcription factor 6 beta; Creb-rp; cAMP response element-binding protein-related protein; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:12915); (R-MMU-8874177)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;14656967;21750661;37828378;9795100", "class_list": "", "function": "Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR)., [UniProtKB, UniProtKB]; Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005769 early endosome", "go_biological_process": "GO:1903892 negative regulation of ATF6-mediated unfolded protein response;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35451-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VH0-1", "uniprot_id": "BANK1_MOUSE", "mass": 89406.0, "length": 783, "protein_name": "B-cell scaffold protein with ankyrin repeats", "gene_name": "Bank1", "organism": "Mouse", "refseq_name": "B-cell scaffold protein with ankyrin repeats isoform 1", "refseq_ac": "NP_001028522", "gene_names_uniprotkb": "Bank1", "gene_names_refseq": "A530094C12Rik; AVIEF; BANK; Bank1", "protein_names_uniprotkb": "B-cell scaffold protein with ankyrin repeats; Protein AVIEF", "protein_names_refseq": "B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript; B-cell scaffold protein with ankyrin repeats isoform 1", "tax_id": 10090, "disease": "diffuse scleroderma (Disease Ontology:DOID:1580); systemic scleroderma (Disease Ontology:DOID:418); autoimmune thyroiditis (Disease Ontology:DOID:7188); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:242248)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11782428;16546095;20173027;21183079;21750661;26495903;26522721;27802388;29370826;30016332;31219806;31243359;34428180;36210013", "class_list": "", "function": "B cell responses were enhanced due to decreased B cell scaffold protein with ankyrin repeats 1 (BANK1) levels in collagen-induced arthritis (CIA) mice. Publication Status: Online-Only, [RefSeq, PubMed]; BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses., [RefSeq, PubMed]; BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells., [RefSeq, PubMed]; Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development Publication Status: Online-Only, [RefSeq, PubMed]; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 (By similarity)., [UniProtKB]; The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QMV3;Q3U178;Q8BRV6;Q8BRY8", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0035591 signaling adaptor activity;GO:0043274 phospholipase binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0043410 positive regulation of MAPK cascade;GO:0032715 negative regulation of interleukin-6 production;GO:0042113 B cell activation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80VH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35855-1", "uniprot_id": "BCAT2_MOUSE", "mass": 44127.0, "length": 393, "protein_name": "Branched-chain-amino-acid aminotransferase, mitochondrial", "gene_name": "Bcat2", "organism": "Mouse", "refseq_name": "branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_033867", "gene_names_uniprotkb": "Bcat2; Bcatm; Eca40", "gene_names_refseq": "Bcat(m); Bcat-2; Bcat2; Eca40", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, mitochondrial; 2.6.1.42; BCAT(m)", "protein_names_refseq": "branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor; branched-chain-amino-acid aminotransferase, mitochondrial", "tax_id": 10090, "disease": "hypervalinemia and hyperleucine-isoleucinemia (Disease Ontology:DOID:0060950); amino acid metabolic disorder (Disease Ontology:DOID:9252); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (mmu:12036); (R-MMU-70895)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14755340;17767905;21540332;21750661;22645316;34478752;35075301;37507081;38581348;9165094", "class_list": "", "function": "Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice., [RefSeq, PubMed]; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:14755340, PubMed:17767905). Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes (PubMed:17767905, PubMed:35075301). Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (PubMed:35075301). May also function as a transporter of branched chain alpha-keto acids (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD03", "ec_number_list": "2.6.1.42", "go_molecular_function": "GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0050873 brown fat cell differentiation;GO:0097009 energy homeostasis;GO:1990830 cellular response to leukemia inhibitory factor;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D864-1", "uniprot_id": "ARP6_MOUSE", "mass": 45785.0, "length": 396, "protein_name": "Actin-related protein 6", "gene_name": "Actr6", "organism": "Mouse", "refseq_name": "actin-related protein 6 isoform 1", "refseq_ac": "NP_080190", "gene_names_uniprotkb": "Actr6", "gene_names_refseq": "2010200J04Rik; Actr6; Arp6; ArpX; CDA12", "protein_names_uniprotkb": "Actin-related protein 6; mArp6", "protein_names_refseq": "ARP6 actin-related protein 6 homolog; actin-related protein 6 isoform 1; actin-related protein 6; mArp6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67019)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18299400;20484733;21750661;21952136;23806337;25428507;25605945;30779550;34428180;35820727", "class_list": "", "function": "Required for formation and/or maintenance of proper nucleolar structure and function (By similarity). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTV8", "ec_number_list": "", "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005856 cytoskeleton;GO:0000812 Swr1 complex", "go_biological_process": "GO:0007000 nucleolus organization;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0016479 negative regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q09200-1", "uniprot_id": "B4GN1_MOUSE", "mass": 59212.0, "length": 533, "protein_name": "Beta-1,4 N-acetylgalactosaminyltransferase 1", "gene_name": "B4galnt1", "organism": "Mouse", "refseq_name": "beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1", "refseq_ac": "NP_032106", "gene_names_uniprotkb": "B4galnt1; Galgt1; Galgt; Ggm2", "gene_names_refseq": "4933429D13Rik; B4galnt1; Gal-NAc-T; GalNAc-T; GalNAcT; Galgt1; Ggm-2; Ggm2", "protein_names_uniprotkb": "Beta-1,4 N-acetylgalactosaminyltransferase 1; (N-acetylneuraminyl)-galactosylglucosylceramide; 2.4.1.92; GM2/GD2 synthase; GalNAc-T", "protein_names_refseq": "(N-acetylneuraminyl)-galactosylglucosylceramide; GM2/GD2 synthase; UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)- galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform 1; beta-1,4 N-acetylgalactosaminyltransferase 1; beta1,4GalNAC-T", "tax_id": 10090, "disease": "hereditary spastic paraplegia 26 (Disease Ontology:DOID:0110777)", "pathway": " (mmu:14421); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15953602;21483489;21750661;26495903;31219806;34428180;36210013;36999634;7558008;7821435;8855236", "class_list": "glycogene;glycosyltransferase", "function": "Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene. Review article, [RefSeq, PubMed]; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2., [UniProtKB, PubMed]; Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 28, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.92", "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0007283 spermatogenesis;GO:0060173 limb development;GO:0006687 glycosphingolipid metabolic process;GO:0019915 lipid storage", "synthesized_glycan_count": 72, "hit_score": 1.7, "record_id": "Q09200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2S9-1", "uniprot_id": "ARP8_MOUSE", "mass": 70546.0, "length": 624, "protein_name": "Actin-related protein 8", "gene_name": "Actr8", "organism": "Mouse", "refseq_name": "actin-related protein 8", "refseq_ac": "NP_081769", "gene_names_uniprotkb": "Actr8; Arp8", "gene_names_refseq": "5730542K05Rik; ARP8; Actr8", "protein_names_uniprotkb": "Actin-related protein 8", "protein_names_refseq": "ARP8 actin-related protein 8 homolog; actin-related protein 8 homolog; actin-related protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:56249); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20971067;21750661;34428180", "class_list": "", "function": "Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity)., [UniProtKB]; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYC4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R2S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AWT3-1", "uniprot_id": "AT7L3_MOUSE", "mass": 38594.0, "length": 347, "protein_name": "Ataxin-7-like protein 3", "gene_name": "Atxn7l3", "organism": "Mouse", "refseq_name": "ataxin-7-like protein 3 isoform a", "refseq_ac": "NP_001092306", "gene_names_uniprotkb": "Atxn7l3", "gene_names_refseq": "Atxn7l3; E030022H21Rik", "protein_names_uniprotkb": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog", "protein_names_refseq": "SAGA-associated factor 11 homolog; ataxin-7-like protein 3 isoform a; ataxin-7-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:217218)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AWT2;A2AWT4;Q8C1T7", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071819 DUBm complex;GO:0000124 SAGA complex;GO:0070461 SAGA-type complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AWT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3FIN4-1", "uniprot_id": "AT8B5_MOUSE", "mass": 135899.0, "length": 1183, "protein_name": "Phospholipid-transporting ATPase FetA", "gene_name": "Atp8b5", "organism": "Mouse", "refseq_name": "phospholipid-transporting ATPase FetA", "refseq_ac": "NP_796169", "gene_names_uniprotkb": "Atp8b5; Feta", "gene_names_refseq": "4930417M19Rik; Atp8b5; Feta", "protein_names_uniprotkb": "Phospholipid-transporting ATPase FetA; 7.6.2.1; ATPase class I type 8B member 2-like protein; ATPase class I type 8B member 5; Flippase expressed in testis A", "protein_names_refseq": "ATPase class I type 8B member 2-like protein; flippase expressed in testis A; phospholipid-transporting ATPase FetA; probable phospholipid-transporting ATPase FetA; testis flippase", "tax_id": 10090, "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (mmu:320571)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19657017;21750661", "class_list": "", "function": "P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation., [UniProtKB, PubMed]; These findings point to an essential role of FetA in Golgi morphology and secretory function, suggesting a crucial role for this novel murine P4-ATPase in spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIL8;Q8BVE9;Q8BVS7", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0015914 phospholipid transport;GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3FIN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCX2-1", "uniprot_id": "ATP5H_MOUSE", "mass": 18749.0, "length": 161, "protein_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "gene_name": "Atp5pd", "organism": "Mouse", "refseq_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "refseq_ac": "NP_082138", "gene_names_uniprotkb": "Atp5pd; Atp5h", "gene_names_refseq": "0610009D10Rik; Atp5h; Atp5pd", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase peripheral stalk subunit d; ATPase subunit d", "protein_names_refseq": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase subunit d, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D; ATPase subunit d", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:71679); (R-MMU-163210); (R-MMU-8949613); (R-MMU-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "16916647;21750661;22872234;23576753;23806337;30084848;30124467;32973183;34428180;36288343;37453647;37507081;39927985", "class_list": "", "function": "Multimodality resistance arises through a core metabolic reprogramming pathway instigated by epigenetic loss of the ATP synthase subunit ATP5H, which leads to ROS accumulation and HIF-1alpha stabilization under normoxia, [RefSeq, PubMed]; Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASE1;Q542H1;Q7M0I0;Q91YK9", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043209 myelin sheath;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DCX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPQ9-1", "uniprot_id": "ARRD3_MOUSE", "mass": 46275.0, "length": 414, "protein_name": "Arrestin domain-containing protein 3", "gene_name": "Arrdc3", "organism": "Mouse", "refseq_name": "arrestin domain-containing protein 3", "refseq_ac": "NP_001036056", "gene_names_uniprotkb": "Arrdc3; Kiaa1376", "gene_names_refseq": "Arrdc3; mKIAA1376", "protein_names_uniprotkb": "Arrestin domain-containing protein 3", "protein_names_refseq": "arrestin domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:105171)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19605364;21750661;21982743;32634127;32756918;34428180;37828378;38097622", "class_list": "", "function": "Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:21982743). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Arrestin domain containing 3 promotes Helicobacter pylori-associated gastritis by regulating protease-activated receptor 1. Publication Status: Online-Only, [RefSeq, PubMed]; Comprehensive multi-omics analysis uncovers a group of TGF-beta-regulated genes among lncRNA EPR direct transcriptional targets., [RefSeq, PubMed]; Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses., [RefSeq, PubMed]; Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMN0;Q80TE6;Q8K0L7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0031699 beta-3 adrenergic receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0009612 response to mechanical stimulus;GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0043588 skin development;GO:0031651 negative regulation of heat generation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TPQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMG1-1", "uniprot_id": "ATRIP_MOUSE", "mass": 85548.0, "length": 785, "protein_name": "ATR-interacting protein", "gene_name": "Atrip", "organism": "Mouse", "refseq_name": "ATR-interacting protein", "refseq_ac": "NP_766362", "gene_names_uniprotkb": "Atrip", "gene_names_refseq": "6620401K05Rik; Atrip", "protein_names_uniprotkb": "ATR-interacting protein; ATM and Rad3-related-interacting protein", "protein_names_refseq": "ATM and Rad3 related interacting protein; ATR-interacting protein", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569)", "pathway": " (mmu:235610); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;20801936;21750661;25428506;31219806;32994318;34428180", "class_list": "", "function": "Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QLS8", "ec_number_list": "", "go_molecular_function": "GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070310 ATR-ATRIP complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006139 nucleobase-containing compound metabolic process;GO:0000077 DNA damage checkpoint signaling;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BMG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2F6-1", "uniprot_id": "BCL3_MOUSE", "mass": 47216.0, "length": 448, "protein_name": "B-cell lymphoma 3 protein homolog", "gene_name": "Bcl3", "organism": "Mouse", "refseq_name": "B-cell lymphoma 3 protein homolog", "refseq_ac": "NP_291079", "gene_names_uniprotkb": "Bcl3", "gene_names_refseq": "Bcl-3; Bcl3", "protein_names_uniprotkb": "B-cell lymphoma 3 protein homolog; BCL-3", "protein_names_refseq": "B-cell CLL/lymphoma 3; B-cell lymphoma 3 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:12051)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10361130;16713561;19893491;21750661;34428180;36852467;38804132", "class_list": "", "function": "Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as a transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation., [UniProtKB, PubMed]; Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0030674 protein-macromolecule adaptor activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002455 humoral immune response mediated by circulating immunoglobulin", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z2F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWX0-1", "uniprot_id": "ASTER_MOUSE", "mass": 12068.0, "length": 106, "protein_name": "PAT complex subunit Asterix", "gene_name": "Wdr83os", "organism": "Mouse", "refseq_name": "PAT complex subunit Asterix", "refseq_ac": "NP_001001493", "gene_names_uniprotkb": "Wdr83os; BC056474", "gene_names_refseq": "PAT-10; PAT10; Wdr83os", "protein_names_uniprotkb": "PAT complex subunit Asterix; PAT-10; PAT10; Protein WDR83OS homolog; Protein associated with the ER translocon of 10kDa", "protein_names_refseq": "PAT complex subunit Asterix; UPF0139 membrane protein C19orf56 homolog; protein Asterix; protein WDR83OS homolog; protein associated with the ER translocon of 10kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:414077)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30250217", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0101031 protein folding chaperone complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6ZWX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXA6-1", "uniprot_id": "BAT1_MOUSE", "mass": 53747.0, "length": 487, "protein_name": "b(0,+)-type amino acid transporter 1", "gene_name": "Slc7a9", "organism": "Mouse", "refseq_name": "B(0,+)-type amino acid transporter 1", "refseq_ac": "NP_001185944", "gene_names_uniprotkb": "Slc7a9; Bat1", "gene_names_refseq": "CSNU3; Slc7a9", "protein_names_uniprotkb": "b(0,+)-type amino acid transporter 1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9; b(0,+)AT1", "protein_names_refseq": "B(0,+)-type amino acid transporter 1; b(0,+)AT; b, + amino acid transporter; b, +AT; glycoprotein-associated amino acid transporter b0,+AT1; solute carrier family 7 member 9", "tax_id": 10090, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (mmu:30962); (R-MMU-210991); (R-MMU-352230)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10588648;10799513;12167606;12915471;15044460;21750661;30084848;32873097", "class_list": "", "function": "A decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption, [RefSeq, PubMed]; Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10588648). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mouse amino acid transport system B0 is a neutral amino acid transporter related to Hartnup disorder, [RefSeq, PubMed]; Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis, [RefSeq, PubMed]; Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0042605 peptide antigen binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0006865 amino acid transport;GO:0015804 neutral amino acid transport;GO:0015811 L-cystine transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWQ3-1", "uniprot_id": "ATP23_MOUSE", "mass": 21710.0, "length": 201, "protein_name": "Mitochondrial inner membrane protease ATP23 homolog", "gene_name": "Atp23", "organism": "Mouse", "refseq_name": "mitochondrial inner membrane protease ATP23 homolog isoform 2", "refseq_ac": "NP_081134", "gene_names_uniprotkb": "Atp23; Xrcc6bp1", "gene_names_refseq": "1110068E08Rik; 2410012H02Rik; Atp23; Xrcc6bp1", "protein_names_uniprotkb": "Mitochondrial inner membrane protease ATP23 homolog; 3.4.24.-; XRCC6-binding protein 1", "protein_names_refseq": "XRCC6 binding protein 1; mitochondrial inner membrane protease ATP23 homolog isoform 2; mitochondrial inner membrane protease ATP23 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68876)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0034982 mitochondrial protein processing;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54904-1", "uniprot_id": "B3GT1_MOUSE", "mass": 37993.0, "length": 326, "protein_name": "Beta-1,3-galactosyltransferase 1", "gene_name": "B3galt1", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyltransferase 1", "refseq_ac": "NP_064679", "gene_names_uniprotkb": "B3galt1", "gene_names_refseq": "B3galt1; beta3Gal-T1", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 1; 2.4.1.86; Beta-1,3-GalTase 1; Beta3Gal-T1; Beta3GalT1; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-I; UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1", "protein_names_refseq": "UDP-galactose:beta-N-acetylglucosamine beta1, 3-galactosyltransferase 1; beta-1,3-GalTase 1; beta-1,3-galactosyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26877); (R-MMU-9037629)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;9417047", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91V52", "ec_number_list": "2.4.1.86;2.4.1.-;2.4.1.62", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006682 galactosylceramide biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0006678 glucosylceramide metabolic process", "synthesized_glycan_count": 300, "hit_score": 0.6, "record_id": "O54904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35623-1", "uniprot_id": "BET1_MOUSE", "mass": 13274.0, "length": 118, "protein_name": "BET1 homolog", "gene_name": "Bet1", "organism": "Mouse", "refseq_name": "BET1 homolog", "refseq_ac": "NP_033878", "gene_names_uniprotkb": "Bet1", "gene_names_refseq": "Bet-1; Bet1", "protein_names_uniprotkb": "BET1 homolog; Golgi vesicular membrane-trafficking protein p18; mBET1", "protein_names_refseq": "BET1 homolog; blocked early in transport 1 homolog; golgi vesicular membrane-trafficking protein p18", "tax_id": 10090, "disease": "congenital muscular dystrophy with rapid progression (Disease Ontology:DOID:0061202)", "pathway": " (mmu:12068); (R-MMU-204005); (R-MMU-6807878)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19144319;9382863", "class_list": "", "function": "Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54962-1", "uniprot_id": "BAF_MOUSE", "mass": 10103.0, "length": 89, "protein_name": "Barrier-to-autointegration factor", "gene_name": "Banf1", "organism": "Mouse", "refseq_name": "barrier-to-autointegration factor", "refseq_ac": "NP_001033320", "gene_names_uniprotkb": "Banf1; Baf; L2bp1", "gene_names_refseq": "Baf; Banf1; Bcrp1; L2bp1/Baf", "protein_names_uniprotkb": "Barrier-to-autointegration factor; LAP2-binding protein 1", "protein_names_refseq": "LAP2-binding protein 1; barrier to autointegration factor 1; barrier-to-autointegration factor; breakpoint cluster region protein 1", "tax_id": 10090, "disease": "Nestor-Guillermo progeria syndrome (Disease Ontology:DOID:0081334); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:23825); (R-MMU-2980766); (R-MMU-2995383)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10393804;14523012;16075062;24945635;32156810;37838622;9465049", "class_list": "", "function": "BAF can act in a phosphorylation-regulated manner to impair HSV-1 transcription and/or DNA replication. Publication Status: Online-Only, [RefSeq, PubMed]; BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons., [RefSeq, PubMed]; Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Publication Status: Online-Only, [RefSeq, PubMed]; HB and barrier-to-autointegration factor are the same protein, [RefSeq, PubMed]; Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (By similarity). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (By similarity). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (By similarity). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (By similarity). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32156810). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (By similarity). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (By similarity). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542E6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0045071 negative regulation of viral genome replication;GO:0006325 chromatin organization;GO:0007084 mitotic nuclear membrane reassembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70479-1", "uniprot_id": "BACD2_MOUSE", "mass": 36134.0, "length": 316, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "gene_name": "Tnfaip1", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "refseq_ac": "NP_001152864", "gene_names_uniprotkb": "Tnfaip1; Edp1", "gene_names_refseq": "Bacurd2; Edp-1; Edp1; Tnfaip1; Tnfip1", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor, alpha-induced protein 1, endothelial", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; tumor necrosis factor induced protein 1", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:21927); (R-MMU-9696264); (R-MMU-9696270)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "33159672;34428180;37302538;37422785;37828378;38878215;9804998", "class_list": "", "function": "Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity)., [UniProtKB]; TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH85;Q3UGQ5;Q8BV61;Q8BZK5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006955 immune response;GO:0016477 cell migration;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70479-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1RLK6-1", "uniprot_id": "B3GN4_MOUSE", "mass": 39873.0, "length": 350, "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4", "gene_name": "B3gnt4", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4", "refseq_ac": "NP_941013", "gene_names_uniprotkb": "B3gnt4", "gene_names_refseq": "1010001G17Rik; B3gnt4; BGnT-4", "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; 2.4.1.-; 2.4.1.149; BGnT-4; Beta-1,3-Gn-T4; Beta-1,3-N-acetylglucosaminyltransferase 4; Beta3Gn-T4; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4", "protein_names_refseq": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; beta-1,3-Gn-T4; beta3Gn-T4", "tax_id": 10090, "disease": "", "pathway": " (mmu:231727); (R-MMU-2022854); (R-MMU-913709)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 9552, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QPF4;Q923H4", "ec_number_list": "2.4.1.-;2.4.1.149;2.4.1.147;2.4.1.146;2.4.1.206", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 1159, "hit_score": 0.6, "record_id": "Q1RLK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYD4-1", "uniprot_id": "ARSG_MOUSE", "mass": 57434.0, "length": 525, "protein_name": "Arylsulfatase G", "gene_name": "Arsg", "organism": "Mouse", "refseq_name": "arylsulfatase G isoform 2", "refseq_ac": "NP_001159649", "gene_names_uniprotkb": "Arsg; Kiaa1001", "gene_names_refseq": "6330406P08Rik; ASG; Arsg", "protein_names_uniprotkb": "Arylsulfatase G; 3.1.6.15; 3.1.6.1; ASG; N-sulfoglucosamine-3-sulfatase", "protein_names_refseq": "N-sulfoglucosamine-3-sulfatase; arylsulfatase G isoform 2", "tax_id": 10090, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); mucopolysaccharidosis (Disease Ontology:DOID:12798)", "pathway": " (mmu:74008); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16174644;22689975;25135642;25428506;30899004", "class_list": "glycogene", "function": "Displays arylsulfatase activity at acidic pH towards the artificial substrate p-nitrocatechol sulfate (PubMed:25135642). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (PubMed:22689975)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AT67;B1AT68;Q5XFU5;Q69ZT6;Q8CHS3;Q8VBZ5;Q9D3B4", "ec_number_list": "3.1.6.2;3.1.6.8;3.1.6.12;3.1.6.-;3.1.6.1;3.1.6.15;3.1.6.14;1.8.3.7;3.1.6.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0033889 N-sulfoglucosamine-3-sulfatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0060041 retina development in camera-type eye;GO:0007040 lysosome organization;GO:0006790 sulfur compound metabolic process;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3TYD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U129-1", "uniprot_id": "QTGAL_MOUSE", "mass": 40644.0, "length": 357, "protein_name": "Queuosine-tRNA galactosyltransferase", "gene_name": "Qtgal", "organism": "Mouse", "refseq_name": "queuosine-tRNA galactosyltransferase", "refseq_ac": "NP_848779", "gene_names_uniprotkb": "Qtgal; B3gntl1", "gene_names_refseq": "6030413G23Rik; B3gntl1; Qtgal", "protein_names_uniprotkb": "Queuosine-tRNA galactosyltransferase; 2.4.1.-; BGnT-like protein 1; Beta1,3-N-acetylglucosaminyltransferase-like protein 1; Beta3Gn-T-like protein 1; Beta3GnTL1; QTGAL; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1", "protein_names_refseq": "BGnT-like protein 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; beta1,3-N-acetylglucosaminyltransferase-like protein 1; beta3Gn-T-like protein 1; beta3GnTL1; ortholog of human UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 B3GNTL1; queuosine-tRNA galactosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:210004); (R-MMU-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that specifically catalyzes galactosylation of cytoplasmic tRNA(Tyr) modified with queuosine at position 34 (queuosine(34)). Galactosylates the cyclopentene hydroxyl group of queuosine(34) in tRNA(Tyr) to form galactosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Tyr) is required to slow-down elongation at cognate codons UAC and suppress stop codon readthrough, thereby regulating protein translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNC6;Q5HZJ4;Q8BLR1;Q8C0H0;Q8R1Y3", "ec_number_list": "2.4.1.-;2.4.1.149;2.4.1.147;2.4.1.146;2.4.1.206", "go_molecular_function": "GO:0141125 tRNA-queuosine(34) galactosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U129-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHR0-1", "uniprot_id": "BAHC1_MOUSE", "mass": 282520.0, "length": 2643, "protein_name": "BAH and coiled-coil domain-containing protein 1", "gene_name": "Bahcc1", "organism": "Mouse", "refseq_name": "BAH and coiled-coil domain-containing protein 1", "refseq_ac": "NP_001334550", "gene_names_uniprotkb": "Bahcc1; Kiaa1447", "gene_names_refseq": "B930044J06; Bahcc1", "protein_names_uniprotkb": "BAH and coiled-coil domain-containing protein 1", "protein_names_refseq": "BAH and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268515)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16807365;25428506;34418053;38290642;38452334", "class_list": "", "function": "Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia., [RefSeq, PubMed]; Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2AS78;Q0KK52;Q0KK57;Q3TPP4;Q3UHG9;Q6GQV4;Q6P9S8;Q6PFC9;Q80UX2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "", "go_biological_process": "GO:0007626 locomotory behavior;GO:0030182 neuron differentiation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UHR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5JCS9-1", "uniprot_id": "B3GN3_MOUSE", "mass": 42586.0, "length": 372, "protein_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3", "gene_name": "B3gnt3", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3", "refseq_ac": "NP_082465", "gene_names_uniprotkb": "B3gnt3", "gene_names_refseq": "2210008L19Rik; B3gnt3", "protein_names_uniprotkb": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; 2.4.1.146; 2.4.1.149; BGnT-3; Beta-1,3-Gn-T3; Beta-1,3-N-acetylglucosaminyltransferase 3; Beta3Gn-T3; Core 1 extending beta-1,3-N-acetylglucosaminyltransferase; Core1-beta3GlcNAcT; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3", "protein_names_refseq": "BGnT-3; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; beta-1,3-Gn-T3; beta-1,3-N-acetylglucosaminyltransferase 3; beta3Gn-T3; core 1 beta-1,3-N-acetylglucosaminyltransferase; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; core1-beta3GlcNAcT", "tax_id": 10090, "disease": "", "pathway": " (mmu:72297); (R-MMU-2022854); (R-MMU-913709); (R-MMU-9931295)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0U2;Q9D7Z2", "ec_number_list": "2.4.1.-;2.4.1.149;2.4.1.147;2.4.1.146;2.4.1.206", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 1046, "hit_score": 0.4, "record_id": "Q5JCS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60765-1", "uniprot_id": "ATF3_MOUSE", "mass": 20722.0, "length": 181, "protein_name": "Cyclic AMP-dependent transcription factor ATF-3", "gene_name": "Atf3", "organism": "Mouse", "refseq_name": "cyclic AMP-dependent transcription factor ATF-3", "refseq_ac": "NP_031524", "gene_names_uniprotkb": "Atf3", "gene_names_refseq": "Atf3; LRG-21", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3; Transcription factor LRG-21; cAMP-dependent transcription factor ATF-3", "protein_names_refseq": "cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3; transcription factor LRG-21", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (mmu:11910)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11916968;22242125;34428180;8960123", "class_list": "", "function": "This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (PubMed:11916968). Represses transcription from promoters with ATF sites (PubMed:11916968). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60765-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61334-1", "uniprot_id": "BAP29_MOUSE", "mass": 27964.0, "length": 240, "protein_name": "B-cell receptor-associated protein 29", "gene_name": "Bcap29", "organism": "Mouse", "refseq_name": "B-cell receptor-associated protein 29", "refseq_ac": "NP_001157562", "gene_names_uniprotkb": "Bcap29; Bap29", "gene_names_refseq": "Bap29; Bcap29", "protein_names_uniprotkb": "B-cell receptor-associated protein 29; BCR-associated protein 29; Bap29", "protein_names_refseq": "B-cell receptor-associated protein 29; BCR-associated protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:12033)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12886015;15187134;25605945;26495903;31219806;34428180;36210013;8070407", "class_list": "", "function": "A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum., [RefSeq, PubMed]; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)., [UniProtKB]; Results are consistent with the view that class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006915 apoptotic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0070973 protein localization to endoplasmic reticulum exit site", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVR0-1", "uniprot_id": "BAFL_MOUSE", "mass": 10267.0, "length": 90, "protein_name": "Barrier-to-autointegration factor-like protein", "gene_name": "Banf2", "organism": "Mouse", "refseq_name": "barrier-to-autointegration factor-like protein", "refseq_ac": "NP_001038215", "gene_names_uniprotkb": "Banf2; Bafl", "gene_names_refseq": "4930517K23Rik; Baf-L; Baf-like; Banf2; Gm115", "protein_names_uniprotkb": "Barrier-to-autointegration factor-like protein; BAF-L; Barrier-to-autointegration factor 2", "protein_names_refseq": "barrier to autointegration factor 2; barrier-to-autointegration factor-like protein; likely ortholog of H. sapiens Chromosome 20 open reading frame 179 (C20orf179)", "tax_id": 10090, "disease": "Nestor-Guillermo progeria syndrome (Disease Ontology:DOID:0081334)", "pathway": " (mmu:403171)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33951625", "class_list": "", "function": "May play a role in BANF1 regulation and influence tissue-specific roles of BANF1., [UniProtKB]; Mus musculus Barrier-To-Autointegration Factor 2 (Banf2) is Not Essential for Spermatogenesis or Fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0M9-1", "uniprot_id": "ASGL1_MOUSE", "mass": 33950.0, "length": 326, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "Asrgl1", "organism": "Mouse", "refseq_name": "isoaspartyl peptidase/L-asparaginase", "refseq_ac": "NP_079886", "gene_names_uniprotkb": "Asrgl1", "gene_names_refseq": "2410004D18Rik; ALP1; ALP; Asrgl1", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "L-asparaginase; L-asparagine amidohydrolase; asparaginase-like protein 1; beta-aspartyl-peptidase; isoaspartyl dipeptidase; isoaspartyl peptidase/L-asparaginase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66514); (R-MMU-8964208)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "27106100;36011372;37507081;39927985", "class_list": "", "function": "A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WC8;Q9CVX3", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.4.19.5", "go_molecular_function": "GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006508 proteolysis;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C0M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3W0-2", "uniprot_id": "BABA2_MOUSE", "mass": 43545.0, "length": 383, "protein_name": "BRISC and BRCA1-A complex member 2", "gene_name": "Babam2", "organism": "Mouse", "refseq_name": "BRISC and BRCA1-A complex member 2 isoform V", "refseq_ac": "NP_653124", "gene_names_uniprotkb": "Babam2; Bre", "gene_names_refseq": "6030405P19Rik; B830038C02Rik; Babam2; Bre", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein", "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRISC and BRCA1-A complex member 2 isoform V; brain and reproductive organ-expressed protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:107976); (R-MMU-5689901); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-69473)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11676476;14565866;18299400;19224205;20173027;21952136;25428506;25428507;25605945;28436570;33649389;34428180;35820727;35864959;9737713", "class_list": "", "function": "A highly conserved gene in two species can generate alternative transcripts different in both of the sequence structure and expression pattern, as well as a similar class of transcripts resulting from unconventional transcript processing., [RefSeq, PubMed]; Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Bre enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53., [RefSeq, PubMed]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins (By similarity). May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:9737713)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497G6;Q6P8Z2;Q8BKU1;Q8CJ13;Q8JZP0;Q8K3V9;Q8VHN1", "ec_number_list": "", "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8K3W0-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KN1-1", "uniprot_id": "ARRD1_MOUSE", "mass": 46330.0, "length": 434, "protein_name": "Arrestin domain-containing protein 1", "gene_name": "Arrdc1", "organism": "Mouse", "refseq_name": "arrestin domain-containing protein 1 isoform a", "refseq_ac": "NP_001155957", "gene_names_uniprotkb": "Arrdc1", "gene_names_refseq": "Arrdc1", "protein_names_uniprotkb": "Arrestin domain-containing protein 1; Alpha-arrestin 1", "protein_names_refseq": "alpha-arrestin 1; arrestin domain-containing protein 1 isoform a; arrestin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215705)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23886940;27462458;34428180", "class_list": "", "function": "Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIS7;A2AIS8;Q3TDT6;Q8VEG7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:1990763 arrestin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006858 extracellular transport;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99KN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPW4-1", "uniprot_id": "ARPC5_MOUSE", "mass": 16288.0, "length": 151, "protein_name": "Actin-related protein 2/3 complex subunit 5", "gene_name": "Arpc5", "organism": "Mouse", "refseq_name": "actin-related protein 2/3 complex subunit 5", "refseq_ac": "NP_080645", "gene_names_uniprotkb": "Arpc5", "gene_names_refseq": "5830443F10Rik; Arpc5; p16-Arc", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 5; Arp2/3 complex 16 kDa subunit; p16-ARC", "protein_names_refseq": "actin-related protein 2/3 complex subunit 5; arp2/3 complex 16 kDa subunit", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); immunodeficiency 113 (Disease Ontology:DOID:0051056); candidiasis (Disease Ontology:DOID:1508); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:67771); (R-MMU-2029482); (R-MMU-3928662); (R-MMU-5663213); (R-MMU-6798695); (R-MMU-8856828)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "22016387;22447776;34428180;36881291;37382373", "class_list": "", "function": "ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality., [RefSeq, PubMed]; ARPC5 is transcriptionally activated by KLF4, and promotes cell migration and invasion in prostate cancer via up-regulating ADAM17 : ARPC5 serves as an oncogene in prostate cancer., [RefSeq, PubMed]; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; GRAIL functions via the ubiquitination and degradation of actin cytoskeleton-associated proteins, in particular Arp2/3-5 and coronin 1A, [RefSeq, PubMed]; Loss of microRNA-dependent regulation of Arpc5, which controls the distribution of germ cell mRNAs between translationally active and inactive pools, results in abnormal round spermatid differentiation and impaired fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9T3;Q9D8E7", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005768 endosome;GO:0014069 postsynaptic density;GO:0030027 lamellipodium", "go_biological_process": "GO:0016477 cell migration;GO:0014909 smooth muscle cell migration;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0051639 actin filament network formation;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0L6-1", "uniprot_id": "BAMBI_MOUSE", "mass": 29198.0, "length": 260, "protein_name": "BMP and activin membrane-bound inhibitor homolog", "gene_name": "Bambi", "organism": "Mouse", "refseq_name": "BMP and activin membrane-bound inhibitor homolog precursor", "refseq_ac": "NP_080781", "gene_names_uniprotkb": "Bambi; Nma", "gene_names_refseq": "2610003H06Rik; Bambi", "protein_names_uniprotkb": "BMP and activin membrane-bound inhibitor homolog; Putative transmembrane protein NMA", "protein_names_refseq": "BMP and activin membrane-bound inhibitor homolog precursor; BMP and activin membrane-bound inhibitor, homolog; putative transmembrane protein NMA", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); prostatitis (Disease Ontology:DOID:14654); aortic valve stenosis (Disease Ontology:DOID:1712); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:68010); (R-MMU-2173788)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11706948;12489181;34428180;38099498", "class_list": "", "function": "And has implications in tumor progression. Genomic organization of the mouse Nma/BAMBI gene and confirmed the chromosomal mapping to human chromosome 10 and mouse chromosome 2., [RefSeq, PubMed]; Epitranscriptional regulation of TGF-beta pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates TGF-beta signaling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP85;Q91XS6", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045893 positive regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D0L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61456-1", "uniprot_id": "CCNA1_MOUSE", "mass": 47772.0, "length": 421, "protein_name": "Cyclin-A1", "gene_name": "Ccna1", "organism": "Mouse", "refseq_name": "cyclin-A1 isoform 1", "refseq_ac": "NP_001292150", "gene_names_uniprotkb": "Ccna1", "gene_names_refseq": "Ccna1", "protein_names_uniprotkb": "Cyclin-A1", "protein_names_refseq": "cyclin-A1 isoform 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:12427); (R-MMU-1538133); (R-MMU-171319); (R-MMU-174184); (R-MMU-176408); (R-MMU-187577); (R-MMU-2559582); (R-MMU-2559586); (R-MMU-5689880); (R-MMU-5693607); (R-MMU-6804116); (R-MMU-6804756); (R-MMU-6804757); (R-MMU-68911); (R-MMU-68949); (R-MMU-69017); (R-MMU-69273); (R-MMU-69478); (R-MMU-69563); (R-MMU-69656); (R-MMU-75035)", "pathway_count": 21, "publication_count": 7, "publication_id_list": "10068472;11585773;21750661;25428506;38454404;8565853;9843212", "class_list": "", "function": "Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5U1", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61456-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXK4-1", "uniprot_id": "SAMTR_MOUSE", "mass": 45952.0, "length": 403, "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "Samtor", "organism": "Mouse", "refseq_name": "S-adenosylmethionine sensor upstream of mTORC1", "refseq_ac": "NP_780521", "gene_names_uniprotkb": "Samtor; B630005N14Rik; Bmt2", "gene_names_refseq": "B630005N14Rik; Bmt2; Samtor", "protein_names_uniprotkb": "S-adenosylmethionine sensor upstream of mTORC1; 2.1.1.-; Probable methyltransferase BMT2 homolog", "protein_names_refseq": "S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60 homolog; base methyltransferase of 25S rRNA 2; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:101148); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H608", "ec_number_list": "7.1.2.2;1.11.1.-;3.6.5.-;2.1.1.-;2.3.2.27;2.7.10.2;2.7.11.1", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0031669 cellular response to nutrient levels;GO:0045947 negative regulation of translational initiation;GO:0038202 TORC1 signaling;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BXK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGM5-1", "uniprot_id": "BEST2_MOUSE", "mass": 57023.0, "length": 508, "protein_name": "Bestrophin-2", "gene_name": "Best2", "organism": "Mouse", "refseq_name": "bestrophin-2", "refseq_ac": "NP_001123666", "gene_names_uniprotkb": "Best2; Vmd2l1", "gene_names_refseq": "Best2; Vmd2l1", "protein_names_uniprotkb": "Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1", "protein_names_refseq": "bestrophin-2; vitelliform macular dystrophy 2-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212989); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15218265;18385076;18400985;20407206;21750661", "class_list": "", "function": "Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma., [RefSeq, PubMed]; Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon, [RefSeq, PubMed]; Forms calcium-sensitive chloride channels. Permeable to bicarbonate., [UniProtKB, UniProtKB]; Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:18400985, PubMed:20407206). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:18400985, PubMed:20407206). Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (PubMed:20407206). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (By similarity). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6H1U9;Q8VCM0", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005254 chloride channel activity;GO:0005217 intracellularly ligand-gated monoatomic ion channel activity;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0160133 bicarbonate channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0051899 membrane depolarization;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0007608 sensory perception of smell;GO:0015701 bicarbonate transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VC17-1", "uniprot_id": "ATS18_MOUSE", "mass": 135244.0, "length": 1219, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 18", "gene_name": "Adamts18", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor", "refseq_ac": "NP_766054", "gene_names_uniprotkb": "Adamts18", "gene_names_refseq": "9630038L21; ADAMTS21; Adamts18; E130314N14Rik", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 18; 3.4.24.-; ADAM-TS 18; ADAM-TS18; ADAMTS-18", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor; a disintegrin and metalloproteinase with thrombospondin motifs 18; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:208936); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;21862674;35820727;38287441", "class_list": "", "function": "ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Adamts18 is expressed in the lens and retina in the developing murine eye., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QNK0;Q8BZD1", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0001654 eye development;GO:0090331 negative regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4VC17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZ57-1", "uniprot_id": "AXDN1_MOUSE", "mass": 126656.0, "length": 1111, "protein_name": "Axonemal dynein light chain domain-containing protein 1", "gene_name": "Axdnd1", "organism": "Mouse", "refseq_name": "axonemal dynein light chain domain-containing protein 1", "refseq_ac": "NP_001333896", "gene_names_uniprotkb": "Axdnd1", "gene_names_refseq": "9430070O13Rik; Axdnd1; Gm979", "protein_names_uniprotkb": "Axonemal dynein light chain domain-containing protein 1", "protein_names_refseq": "axonemal dynein light chain domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77352)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34759295;35386379;38997255", "class_list": "", "function": "AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for spermiogenesis and male fertility probably by regulating the manchette dynamics, spermatid head shaping and sperm flagellum assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5RLL5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007338 single fertilization;GO:0008584 male gonad development;GO:0050900 leukocyte migration;GO:0006900 vesicle budding from membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UZ57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35177-1", "uniprot_id": "CASL_MOUSE", "mass": 93052.0, "length": 833, "protein_name": "Enhancer of filamentation 1", "gene_name": "Nedd9", "organism": "Mouse", "refseq_name": "enhancer of filamentation 1 isoform 1", "refseq_ac": "NP_001104794", "gene_names_uniprotkb": "Nedd9; Casl", "gene_names_refseq": "Cas-L; CasL; HEF1; MEF1; Nedd-9; Nedd9; p105", "protein_names_uniprotkb": "Enhancer of filamentation 1; CAS-L; CRK-associated substrate-related protein; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; mEF1; p105", "protein_names_refseq": "CRK-associated substrate-related protein; Crk-associated substrate lymphocyte-specific protein; enhancer of filamentation 1 isoform 1; enhancer of filamentation 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18003)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10692442;12517963;16148091;17174122;19103205;19365570;21183079;21750661;24574519;25059660;26683084;27336669;27359298;29191835;34428180;35523865", "class_list": "", "function": "Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion, [RefSeq, PubMed]; Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). As a focal adhesion protein, plays a role in embryonic fibroblast migration (PubMed:25059660). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKl and SHPTP2 to the tyrosine phosphorylated form (By similarity). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:16148091, PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (PubMed:27359298). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Positively regulates RANKL-induced osteoclastogenesis (PubMed:27336669). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (PubMed:26683084)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJL8;Q8BK90;Q8BL52;Q8BM94;Q8BMI9;Q99KE7", "ec_number_list": "", "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007611 learning or memory;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35177-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY64-1", "uniprot_id": "BIEA_MOUSE", "mass": 33525.0, "length": 295, "protein_name": "Biliverdin reductase A", "gene_name": "Blvra", "organism": "Mouse", "refseq_name": "biliverdin reductase A", "refseq_ac": "NP_080954", "gene_names_uniprotkb": "Blvra", "gene_names_refseq": "0610006A11Rik; 2500001N03Rik; Blvra; Blvr", "protein_names_uniprotkb": "Biliverdin reductase A; 1.3.1.24; BVR A; Biliverdin-IX alpha-reductase", "protein_names_refseq": "BVR A; biliverdin reductase A; biliverdin-IX alpha-reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:109778); (R-MMU-189483); (R-MMU-9707564)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21183079;21750661;26740625;29195835;32131495;32581154;33300544;37507081", "class_list": "", "function": "Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins., [RefSeq, PubMed]; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9C6;Q80WR6;Q9DD21", "ec_number_list": "1.3.1.-;2.6.99.-;1.5.1.30;1.3.1.24", "go_molecular_function": "GO:0106276 biliberdin reductase (NADH) activity;GO:0106277 biliverdin reductase (NADPH) activity;GO:0004674 protein serine/threonine kinase activity;GO:0008270 zinc ion binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0061010 gallbladder development;GO:1901142 insulin metabolic process;GO:1903409 reactive oxygen species biosynthetic process;GO:0034440 lipid oxidation;GO:0038178 complement component C5a signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CY64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AWP0-1", "uniprot_id": "BIRC7_MOUSE", "mass": 31992.0, "length": 285, "protein_name": "Baculoviral IAP repeat-containing protein 7", "gene_name": "Birc7", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 7 precursor", "refseq_ac": "NP_001156719", "gene_names_uniprotkb": "Birc7; Livin", "gene_names_refseq": "Birc7; E130019N06; KIAP; Livin; ML-IAP", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 7; 2.3.2.27; Livin; RING-type E3 ubiquitin transferase BIRC7", "protein_names_refseq": "RING-type E3 ubiquitin transferase BIRC7; baculoviral IAP repeat-containing protein 7 precursor; baculoviral IAP repeat-containing protein 7", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:329581)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22853455;26094984;26218911;36916467;38332512;38332513", "class_list": "", "function": "Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9., [UniProtKB, UniProtKB]; Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously., [RefSeq, PubMed]; Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF and MMP-2/-9. Its silencing resulted in the prevention of xenograft tumor formation., [RefSeq, PubMed]; Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis., [RefSeq, PubMed]; Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses., [RefSeq, PubMed]; Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression., [RefSeq, PubMed]; ML-IAP is dispensable for both normal mouse development and ocular homoeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AUK9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A2AWP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y55-1", "uniprot_id": "BSDC1_MOUSE", "mass": 46953.0, "length": 427, "protein_name": "BSD domain-containing protein 1", "gene_name": "Bsdc1", "organism": "Mouse", "refseq_name": "BSD domain-containing protein 1", "refseq_ac": "NP_598650", "gene_names_uniprotkb": "Bsdc1", "gene_names_refseq": "1110063F24Rik; Bsdc1", "protein_names_uniprotkb": "BSD domain-containing protein 1", "protein_names_refseq": "BSD domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100383)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;26495903;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KGE2;Q8BI04;Q8VDP1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80Y55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EKE5-1", "uniprot_id": "CATIP_MOUSE", "mass": 59301.0, "length": 520, "protein_name": "Ciliogenesis-associated TTC17-interacting protein", "gene_name": "Catip", "organism": "Mouse", "refseq_name": "ciliogenesis-associated TTC17-interacting protein isoform X2", "refseq_ac": "XP_017176121", "gene_names_uniprotkb": "Catip; Gm216", "gene_names_refseq": "Catip; Gm216", "protein_names_uniprotkb": "Ciliogenesis-associated TTC17-interacting protein", "protein_names_refseq": "ciliogenesis-associated TTC17-interacting protein isoform X2", "tax_id": 10090, "disease": "spermatogenic failure 54 (Disease Ontology:DOID:0112335)", "pathway": " (mmu:241112)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUR2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B9EKE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZR1-1", "uniprot_id": "ATTY_MOUSE", "mass": 50565.0, "length": 454, "protein_name": "Tyrosine aminotransferase", "gene_name": "Tat", "organism": "Mouse", "refseq_name": "tyrosine aminotransferase", "refseq_ac": "NP_666326", "gene_names_uniprotkb": "Tat", "gene_names_refseq": "Tat", "protein_names_uniprotkb": "Tyrosine aminotransferase; 2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase; TAT", "protein_names_refseq": "L-tyrosine:2-oxoglutarate aminotransferase; tyrosine aminotransferase; tyrosine transaminase", "tax_id": 10090, "disease": "tyrosinemia type II (Disease Ontology:DOID:0050725); tyrosinemia (Disease Ontology:DOID:9275)", "pathway": " (mmu:234724); (R-MMU-8963684)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21153519;21750661;30818058;34428180;38011257", "class_list": "", "function": "Tat-CIAPIN1 protein transduced into HT-22cells and significantly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation., [RefSeq, PubMed]; Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus., [RefSeq, PubMed]; This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]., [RefSeq]; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UER7;Q8BTI1", "ec_number_list": "2.6.1.5", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004838 L-tyrosine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006536 glutamate metabolic process;GO:0006979 response to oxidative stress;GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8QZR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPZ1-1", "uniprot_id": "FAME_MOUSE", "mass": 34455.0, "length": 294, "protein_name": "Factor associated with metabolism and energy", "gene_name": "Ccdc198", "organism": "Mouse", "refseq_name": "factor associated with metabolism and energy", "refseq_ac": "NP_080232", "gene_names_uniprotkb": "Ccdc198; C14orf105; Fame", "gene_names_refseq": "1700011H14Rik; Ccdc198", "protein_names_uniprotkb": "Factor associated with metabolism and energy; Protein CCDC198", "protein_names_refseq": "factor associated with metabolism and energy; uncharacterized protein C14orf105 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67082)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37248239", "class_list": "", "function": "May be involved in tuning the metabolism, energy expenditure, and excretion processes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C481;Q8R0Q0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R069-1", "uniprot_id": "BCAM_MOUSE", "mass": 67670.0, "length": 622, "protein_name": "Basal cell adhesion molecule", "gene_name": "Bcam", "organism": "Mouse", "refseq_name": "basal cell adhesion molecule precursor", "refseq_ac": "NP_065232", "gene_names_uniprotkb": "Bcam; Gplu; Lu", "gene_names_refseq": "1200005K12Rik; B-CAM; Bcam; Gplu; Lu", "protein_names_uniprotkb": "Basal cell adhesion molecule; B-CAM cell surface glycoprotein; Lutheran antigen", "protein_names_refseq": "Auberger b antigen; B-CAM cell surface glycoprotein; Lutheran blood group; basal cell adhesion molecule precursor; lutheran antigen; lutheran glycoprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:57278)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10630290;11507772;20485683;21750661;30059007;30084848;35820727", "class_list": "", "function": "Lutheran (Lu)/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8818, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESS5;Q9JKB2", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0005055 laminin receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9R069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2E9-1", "uniprot_id": "BSCL2_MOUSE", "mass": 43105.0, "length": 383, "protein_name": "Seipin", "gene_name": "Bscl2", "organism": "Mouse", "refseq_name": "seipin isoform 1", "refseq_ac": "NP_001129536", "gene_names_uniprotkb": "Bscl2; Gng3lg; MNCb-2630", "gene_names_refseq": "2900097C17Rik; Bscl2; Gng3lg", "protein_names_uniprotkb": "Seipin; Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog", "protein_names_refseq": "Berardinelli-Seip congenital lipodystrophy 2 (seipin); Berardinelli-Seip congenital lipodystrophy 2 homolog (seipin); Bernardinelli-Seip congenital lipodystrophy 2 homolog; G protein gamma 3 linked; bernardinelli-Seip congenital lipodystrophy type 2 protein homolog; seipin isoform 1; seipin", "tax_id": 10090, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); autosomal dominant distal hereditary motor neuronopathy 13 (Disease Ontology:DOID:0081401); hereditary spastic paraplegia 17 (Disease Ontology:DOID:0110770); congenital generalized lipodystrophy type 2 (Disease Ontology:DOID:0111136); male infertility (Disease Ontology:DOID:12336); azoospermia (Disease Ontology:DOID:14227); hereditary spastic paraplegia (Disease Ontology:DOID:2476); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (mmu:14705)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10679242;18458148;19574402;21551454;21750661;21913724;22269949;22872234;23049863;23458123;30084848;30899004;31219806;31599954;34203471;34428180;41196993;9790771", "class_list": "", "function": "Mediates the formation of lipid droplets during the differentiation and maturation of adipocytes (PubMed:18458148, PubMed:19574402, PubMed:21551454, PubMed:22269949, PubMed:23458123, PubMed:41196993). Together with LDAF1, defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm (By similarity). BSCL2 and LDAF1 also regulate protein and lipid delivery from the endoplasmic reticulum into growing lipid droplets: during early adipogenesis, BSCL2 inhibits GPAT3 and GPAT4 activity, thereby preventing phosphatidic acid accumulation that could antagonize PPARG and block differentiation (PubMed:41196993). This inhibition is then relieved by ADIG during adipocyte maturation, allowing expansion of lipid droplets (PubMed:41196993). Regulates the maturation of ZFYVE1-positive nascent lipid droplets and the function of the RAB18-ZFYVE1 complex in mediating the formation of endoplasmic reticulum-lipid droplet contacts (By similarity). Binds anionic phospholipids including phosphatidic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY41;Q3U1S5;Q810B0;Q9JJC2;Q9JMF1", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0043086 negative regulation of catalytic activity;GO:0050995 negative regulation of lipid catabolic process;GO:0045444 fat cell differentiation;GO:0019915 lipid storage", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9Z2E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI32-1", "uniprot_id": "BAG5_MOUSE", "mass": 50943.0, "length": 447, "protein_name": "BAG family molecular chaperone regulator 5", "gene_name": "Bag5", "organism": "Mouse", "refseq_name": "BAG family molecular chaperone regulator 5", "refseq_ac": "NP_001311409", "gene_names_uniprotkb": "Bag5", "gene_names_refseq": "1600025G07Rik; 4930405J06Rik; Bag-5; Bag5", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5", "protein_names_refseq": "BAG family molecular chaperone regulator 5; BAG-family molecular chaperone regulator-5 (BAG-5); bcl-2-associated athanogene 5", "tax_id": 10090, "disease": "dilated cardiomyopathy 2F (Disease Ontology:DOID:0081162)", "pathway": " (mmu:70369); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15603737;20223214;21750661;24475098;25367796;31219806;34428180;35044787;38139359;38454159;38796549", "class_list": "", "function": "A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia. Publication Status: Online-Only, [RefSeq, PubMed]; Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. Publication Status: Online-Only, [RefSeq, PubMed]; BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly., [RefSeq, PubMed]; Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death., [RefSeq, PubMed]; Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (PubMed:35044787). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Knockdown of Bag5 exacerbated Abeta1-42-induced apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVA8;Q8K175;Q9DAU0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0050821 protein stabilization;GO:0031397 negative regulation of protein ubiquitination;GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CI32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97857-1", "uniprot_id": "ATS1_MOUSE", "mass": 105801.0, "length": 968, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 1", "gene_name": "Adamts1", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein", "refseq_ac": "NP_033751", "gene_names_uniprotkb": "Adamts1", "gene_names_refseq": "ADAM-TS1; ADAMTS-1; ADAMTS; Adamts1; C3-C5; METH-1; METH1", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 1; 3.4.24.-; ADAM-TS 1; ADAM-TS1; ADAMTS-1", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein; ADAM-TS 1; a disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ureteral obstruction (Disease Ontology:DOID:5199); urinary tract obstruction (Disease Ontology:DOID:5200); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:11504); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10373500;10781075;10930576;21750661;23233679;25142777;25605945;34418053;37828378;38750698;39122105;8995297;9441751", "class_list": "", "function": "Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development., [RefSeq, PubMed]; Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts under hypoxia and mice with form-deprived myopia., [RefSeq, PubMed]; Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1691-Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (PubMed:10930576, PubMed:9441751). Also cleaves COMP (By similarity). Has angiogenic inhibitor activity (By similarity). May play a critical role in follicular rupture (PubMed:10781075)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QMN9;O54768", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0031410 cytoplasmic vesicle;GO:0005604 basement membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0010976 positive regulation of neuron projection development;GO:0030198 extracellular matrix organization;GO:0001822 kidney development;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P97857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEG5-1", "uniprot_id": "CC28B_MOUSE", "mass": 22033.0, "length": 200, "protein_name": "Coiled-coil domain-containing protein 28B", "gene_name": "Ccdc28b", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 28B", "refseq_ac": "NP_079731", "gene_names_uniprotkb": "Ccdc28b", "gene_names_refseq": "1110002E08Rik; 1810010N17Rik; Ccdc28b", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 28B", "protein_names_refseq": "coiled-coil domain-containing protein 28B", "tax_id": 10090, "disease": "Bardet-Biedl syndrome 1 (Disease Ontology:DOID:0110123); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)", "pathway": " (mmu:66264)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16327777;21183079;21750661;23727834", "class_list": "", "function": "Findings implicate CCDC28B in the regulation of mTORC2, and uncover a novel function of SIN1 regulating cilia length that is likely independent of mTOR signaling., [RefSeq, PubMed]; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ADZ9;Q8K132", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0060271 cilium assembly;GO:0035176 social behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6Z5-1", "uniprot_id": "AUNIP_MOUSE", "mass": 37684.0, "length": 340, "protein_name": "Aurora kinase A- and ninein-interacting protein", "gene_name": "Aunip", "organism": "Mouse", "refseq_name": "aurora kinase A- and ninein-interacting protein", "refseq_ac": "NP_001074568", "gene_names_uniprotkb": "Aunip", "gene_names_refseq": "2610002D18Rik; Aunip; Clhc1", "protein_names_uniprotkb": "Aurora kinase A- and ninein-interacting protein", "protein_names_refseq": "aurora A-binding; aurora kinase A- and ninein-interacting protein; clathrin heavy chain linker domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69885)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30084848;30779550;31599954", "class_list": "", "function": "DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR86", "ec_number_list": "", "go_molecular_function": "GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0007051 spindle organization;GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEI1-1", "uniprot_id": "BOLA3_MOUSE", "mass": 12228.0, "length": 110, "protein_name": "BolA-like protein 3", "gene_name": "Bola3", "organism": "Mouse", "refseq_name": "bolA-like protein 3 isoform 1", "refseq_ac": "NP_780486", "gene_names_uniprotkb": "Bola3", "gene_names_refseq": "1810056O20Rik; Bola3", "protein_names_uniprotkb": "BolA-like protein 3", "protein_names_refseq": "bolA-like 3; bolA-like protein 3 isoform 1; bolA-like protein 3", "tax_id": 10090, "disease": "multiple mitochondrial dysfunctions syndrome 2 (Disease Ontology:DOID:0080134)", "pathway": " (mmu:78653)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30759996;36288343;37507081", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study shows that in vivo, pharmacological knockdown of endothelial BOLA3 and targeted overexpression of BOLA3 promotes histological and hemodynamic manifestations of pulmonary hypertension Erratum:[Circulation. 2025 Apr 29;151(17):e967. doi: 10.1161/CIR.0000000000001337. PMID: 40294142], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0016604 nuclear body;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0097009 energy homeostasis;GO:0006006 glucose metabolic process;GO:0009249 protein lipoylation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CEI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70370-1", "uniprot_id": "CATS_MOUSE", "mass": 38475.0, "length": 340, "protein_name": "Cathepsin S", "gene_name": "Ctss", "organism": "Mouse", "refseq_name": "cathepsin S isoform 2 preproprotein", "refseq_ac": "NP_067256", "gene_names_uniprotkb": "Ctss; Cats", "gene_names_refseq": "Cats; Ctss", "protein_names_uniprotkb": "Cathepsin S; 3.4.22.27", "protein_names_refseq": "Cat S; cathepsin S isoform 2 preproprotein", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); COVID-19 (Disease Ontology:DOID:0080600); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); sarcoidosis (Disease Ontology:DOID:11335); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); carotid artery disease (Disease Ontology:DOID:3407); neuropathy (Disease Ontology:DOID:870); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:13040); (R-MMU-1474228); (R-MMU-1679131); (R-MMU-2022090); (R-MMU-2132295); (R-MMU-6798695); (R-MMU-9766229); (R-MMU-9958810)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10395917;16075062;21750661;26216096;26495903;26740625;28011936;31219806;34428180;37540176;37589754;37801777;39017634;9516475;9545226", "class_list": "", "function": "Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype. Erratum:[Invest Ophthalmol Vis Sci. 2023 Aug 1;64(11):32. doi: 10.1167/iovs.64.11.32. PMID: 37639250], [RefSeq, PubMed]; Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjogren Disease-Like Lacrimal Gland Pathology., [RefSeq, PubMed]; Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS., [RefSeq, PubMed]; Thiol protease (PubMed:26216096). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (By similarity). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). Elicits itch by mediating cleavage and activation of MRGPRX1 (PubMed:26216096)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QK18;O54973", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.4.24.34;3.4.22.27;1.1.1.42;3.4.22.34;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.4.22.15;3.4.21.4;3.6.4.10;3.4.21.-;3.2.1.17;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;3.4.16.5;3.4.16.-;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.4.24.17;3.1.3.48;3.4.24.-;5.3.2.1;5.3.3.12;3.4.24.65;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.4.22.38;3.5.4.5;3.4.25.1;3.4.23.34;3.4.14.1;2.7.4.6;2.7.13.3;3.6.4.6;3.4.24.23;2.7.1.1;2.7.1.-;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;3.4.22.42;1.8.3.2;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;3.2.1.14;5.4.2.11;5.4.2.4;3.4.24.7;2.4.1.1;3.5.1.3;3.4.22.41;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0008233 peptidase activity;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050729 positive regulation of inflammatory response;GO:0045453 bone resorption", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922M3-1", "uniprot_id": "BACD3_MOUSE", "mass": 35701.0, "length": 315, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3", "gene_name": "Kctd10", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1", "refseq_ac": "NP_001153413", "gene_names_uniprotkb": "Kctd10", "gene_names_refseq": "Kctd10; mBACURD3", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; mBACURD3", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; potassium channel tetramerization domain-containing 10", "tax_id": 10090, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:330171)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;22179047;25428506;30084848;30779550;34428180;34854382;35820727;38489388", "class_list": "", "function": "KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13., [RefSeq, PubMed]; KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination. Controls endothelial barrier function by mediating 'Lys-63'-linked polyubiquitination of RHOB, promoting its lysosomal degradation. Mediates polyubiquitination of CEP97, targeting it for proteasomal degradation. CEP97 degradation upon serum starvation is essential for primary cilium formation by enabling removal of the CEP97-CP110 complex from mother centrioles. Acts as a positive regulator of ferroptosis by destabilizing SLC7A11. Decreased SLC7A11 levels reduce cystine uptake and glutathione (GSH) biosynthesis, thereby promoting iron-dependent lipid peroxidation and ferroptotic cell death. In the innate immune response, mediates 'Lys-27'-linked polyubiquitination of TICAM1/TRIF at Lys-523 upon stimulation with LPS. This ubiquitination is essential for recruitment of TICAM1 to TLR3/4, thereby promoting TLR3/4-mediated immune signaling (By similarity). Negatively regulates KCTD13 stability through the ubiquitin/proteasome degradation pathway within the developing brain to control neuronal progenitor cell proliferation and differentiation (PubMed:38489388). Acts as a sensor for co-directional transcription-replication conflicts, where it helps coordinate the interaction between the replication machinery and RNA polymerase to allow DNA replication to continue through actively transcribed regions. Promotes recruitment of ubiquitin ligase complexes that remove stalled transcription factors, thereby maintaining genome stability by resolving these conflicts. Ubiquitinates TCEA2 to remodel the RNAP complex (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036038 MKS complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q922M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URK1-1", "uniprot_id": "CC190_MOUSE", "mass": 32592.0, "length": 288, "protein_name": "Coiled-coil domain-containing protein 190", "gene_name": "Ccdc190", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 190 isoform 1", "refseq_ac": "NP_001028357", "gene_names_uniprotkb": "Ccdc190; 1700084C01Rik", "gene_names_refseq": "1700084C01Rik; Ccdc190", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 190", "protein_names_refseq": "coiled-coil domain-containing protein 190 isoform 1; coiled-coil domain-containing protein 190", "tax_id": 10090, "disease": "", "pathway": " (mmu:78465)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3URK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHI4-1", "uniprot_id": "CARTF_MOUSE", "mass": 76397.0, "length": 689, "protein_name": "Calcium-responsive transcription factor", "gene_name": "Carf", "organism": "Mouse", "refseq_name": "calcium-responsive transcription factor isoform 3", "refseq_ac": "NP_001272402", "gene_names_uniprotkb": "Carf; Als2cr8", "gene_names_refseq": "Als2cr8; Carf; ECBRC-FC1; ECBRC-FC2", "protein_names_uniprotkb": "Calcium-responsive transcription factor; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; CaRF; Calcium-response factor", "protein_names_refseq": "amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog; calcium-response factor CaRF; calcium-responsive transcription factor isoform 3; calcium-responsive transcription factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:241066)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11832226;21750661;23848551;26826701;31219806;34428180;35820727;36210013", "class_list": "", "function": "Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity)., [UniProtKB]; Carf(+/-) and Carf(-/-) mice were impaired in their ability to acquire timed response thresholds relative to Carf(+/+) mice., [RefSeq, PubMed]; Cloned as a calcium- and neural-selective transcriptional activator of the gene for Brain-Derived Neurotrophic Factor (BDNF)., [RefSeq, PubMed]; This report that loss of CaRF leads to enhanced NMDAR-dependent induction of both Bdnf IV and the activity-regulated gene Arc, and we investigate potential mechanisms as well as biological consequences of this change in transcriptional regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRZ9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001652 granular component", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VHI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27784-1", "uniprot_id": "CCL6_MOUSE", "mass": 12984.0, "length": 116, "protein_name": "C-C motif chemokine 6", "gene_name": "Ccl6", "organism": "Mouse", "refseq_name": "C-C motif chemokine 6 precursor", "refseq_ac": "NP_033165", "gene_names_uniprotkb": "Ccl6; C10; Scya6", "gene_names_refseq": "Ccl6; MRP-1; Scya6; c10", "protein_names_uniprotkb": "C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6", "protein_names_refseq": "C-C motif chemokine 6 precursor; C-C motif chemokine 6; CC chemokine C10; chemokine (C-C motif) ligand 6; small-inducible cytokine A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:20305); (R-MMU-416476); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10233856;10438970;15905581;18250455;1832565;26495903;27802388;28011936;28935714;34428180;35984892;36457234;37233907;8176224", "class_list": "", "function": "CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing., [RefSeq, PubMed]; Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection., [RefSeq, PubMed]; Chemotactic factor that attracts mostly macrophage, but it can also attract B cells, CD4(+) lymphocytes and eosinophils., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3W3;Q5QNW1;Q99M24;Q9D830", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031726 CCR1 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P27784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59509-1", "uniprot_id": "ATS19_MOUSE", "mass": 134561.0, "length": 1210, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 19", "gene_name": "Adamts19", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 19 preproprotein", "refseq_ac": "NP_780715", "gene_names_uniprotkb": "Adamts19", "gene_names_refseq": "4831407I23Rik; Adamts19; D230034E10Rik", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 19; 3.4.24.-; ADAM-TS 19; ADAM-TS19; ADAMTS-19", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 19 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 19; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); aortic valve disease (Disease Ontology:DOID:62)", "pathway": " (mmu:240322); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12617826;25605945;31844321;33755662", "class_list": "", "function": "Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of ADAMTS19 causes progressive non-syndromic heart valve disease., [RefSeq, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is predominantly expressed in the ovary with lower levels of expression observed in kidney, heart, skeletal muscle, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate an active protease. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0003183 mitral valve morphogenesis;GO:0060412 ventricular septum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P59509-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59511-1", "uniprot_id": "ATS20_MOUSE", "mass": 212068.0, "length": 1906, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 20", "gene_name": "Adamts20", "organism": "Mouse", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein", "refseq_ac": "NP_803180", "gene_names_uniprotkb": "Adamts20", "gene_names_refseq": "Adamst20; Adamts20; bt", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 20; 3.4.24.-; ADAM-TS 20; ADAM-TS20; ADAMTS-20", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein; a disintegrin and metalloproteinase with thrombospondin motifs 20; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:223838); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12514189;12562771;12925592;18454205;35820727", "class_list": "", "function": "ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 thrombospondin type I repeats and a unique C-terminal domain, and have a similar gene structure, [RefSeq, PubMed]; Adamts20 mutations in belted (bt) mice cause white spotting of the dorsal and ventral torso, indicative of defective neural crest (NC)-derived melanoblast development. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain., [UniProtKB]; Results suggest that the role of ADAMTS proteases, including ADAMTS20, in the regulation of cell migration has been conserved in mammalian development., [RefSeq, PubMed]; This gene encodes a member of 'a disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a 'belted' phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016]., [RefSeq]; This protein is identified and characterized and its relation to other disintegrins and thrombospondin 1 repeats is examined. Erratum:[J Biol Chem. 2018 Jul 27;293(30):11785. doi: 10.1074/jbc.AAC118.004702. PMID: 30054291], [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9QLA1", "ec_number_list": "3.4.24.-;3.4.24.87;2.4.1.-;3.4.24.82;3.4.24.14;2.4.1.221", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0043066 negative regulation of apoptotic process;GO:0009967 positive regulation of signal transduction;GO:0045636 positive regulation of melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59511-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82198-1", "uniprot_id": "BGH3_MOUSE", "mass": 74597.0, "length": 683, "protein_name": "Transforming growth factor-beta-induced protein ig-h3", "gene_name": "Tgfbi", "organism": "Mouse", "refseq_name": "transforming growth factor-beta-induced protein ig-h3 precursor", "refseq_ac": "NP_033395", "gene_names_uniprotkb": "Tgfbi", "gene_names_refseq": "68kDa; Beta-ig; Tgfbi; big-h3", "protein_names_uniprotkb": "Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3", "protein_names_refseq": "transforming growth factor, beta induced, 68 kDa; transforming growth factor-beta-induced protein ig-h3 precursor; transforming growth factor-beta-induced protein ig-h3", "tax_id": 10090, "disease": "granular corneal dystrophy 2 (Disease Ontology:DOID:0060444); epithelial basement membrane dystrophy (Disease Ontology:DOID:0060447); Reis-Bucklers corneal dystrophy (Disease Ontology:DOID:0060453); Thiel-Behnke corneal dystrophy (Disease Ontology:DOID:0060455); granular corneal dystrophy 1 (Disease Ontology:DOID:0080530); corneal dystrophy (Disease Ontology:DOID:2566); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:21810)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12704192;20173027;22299025;25428506;26740625;27802388;30084848;30779550;34428180;37828378;37865162;38849015;8024701", "class_list": "", "function": "A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance., [RefSeq, PubMed]; BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression., [RefSeq, PubMed]; Betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and angiogenesis, [RefSeq, PubMed]; Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9R1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005518 collagen binding;GO:0050839 cell adhesion molecule binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005802 trans-Golgi network;GO:0001527 microfibril", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0002062 chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P82198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03366-1", "uniprot_id": "CCL7_MOUSE", "mass": 10999.0, "length": 97, "protein_name": "C-C motif chemokine 7", "gene_name": "Ccl7", "organism": "Mouse", "refseq_name": "C-C motif chemokine 7 precursor", "refseq_ac": "NP_038682", "gene_names_uniprotkb": "Ccl7; Fic; Mcp3; Scya7", "gene_names_refseq": "Ccl7; MCP-3; Scya7; fic; marc; mcp3", "protein_names_uniprotkb": "C-C motif chemokine 7; Intercrine/chemokine MARC; MCP-3; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; Protein FIC; Small-inducible cytokine A7", "protein_names_refseq": "C-C motif chemokine 7 precursor; C-C motif chemokine 7; RANTES/sis homolog; chemokine (C-C motif) ligand 7; intercrine/chemokine MARC; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small-inducible cytokine A7", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); silicosis (Disease Ontology:DOID:10325); interstitial nephritis (Disease Ontology:DOID:1063); allergic conjunctivitis (Disease Ontology:DOID:11204); multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); pneumonia (Disease Ontology:DOID:552); periapical periodontitis (Disease Ontology:DOID:823); ulcerative colitis (Disease Ontology:DOID:8577); viral infectious disease (Disease Ontology:DOID:934); ethmoid sinusitis (Disease Ontology:DOID:9507); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20306); (R-MMU-380108)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10438970;1281219;17364026;30671055;36998150;38281481;39231238;39805173;7989769;8002978;8455595", "class_list": "", "function": "CCL7 Chemokine Is a Marker but Not a Therapeutic Target of Acute Kidney Injury., [RefSeq, PubMed]; Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues (PubMed:39805173). Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair (PubMed:17364026). Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors (PubMed:39805173). In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain (PubMed:36998150). Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control (PubMed:30671055)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Inhibition of CCL7 improves endothelial dysfunction and vasculopathy in mouse models of diabetes mellitus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0031726 CCR1 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0010332 response to gamma radiation;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TC33-1", "uniprot_id": "CC127_MOUSE", "mass": 30509.0, "length": 260, "protein_name": "Coiled-coil domain-containing protein 127", "gene_name": "Ccdc127", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 127 isoform 2", "refseq_ac": "NP_001162129", "gene_names_uniprotkb": "Ccdc127", "gene_names_refseq": "0610011N22Rik; 5430420E17Rik; A430066A18; C130002N06; Ccdc127", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 127", "protein_names_refseq": "coiled-coil domain-containing protein 127 isoform 2; coiled-coil domain-containing protein 127", "tax_id": 10090, "disease": "", "pathway": " (mmu:67433)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Regulates lipid droplet homeostasis. May be involved in the adipocyte differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPA8;Q9CQ15", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TC33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ULW6-1", "uniprot_id": "CCD33_MOUSE", "mass": 110198.0, "length": 985, "protein_name": "Coiled-coil domain-containing protein 33", "gene_name": "Ccdc33", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 33 isoform 3", "refseq_ac": "NP_001298014", "gene_names_uniprotkb": "Ccdc33", "gene_names_refseq": "4930535E21Rik; Ccdc33; Gm1117; Tzip1", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 33; Speriolin-binding factor", "protein_names_refseq": "coiled-coil domain-containing protein 33 isoform 3; coiled-coil domain-containing protein 33; speriolin-binding factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:382077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20068295;21750661", "class_list": "", "function": "Data show that Ccdc33 encodes a putative peroxisomal protein and is predominantly expressed in male germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B78;Q3TLL8;Q76MG4;Q9D4Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3ULW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUX7-1", "uniprot_id": "CD046_MOUSE", "mass": 11861.0, "length": 111, "protein_name": "Uncharacterized protein C4orf46 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "uncharacterized protein C4orf46 homolog", "refseq_ac": "NP_083758", "gene_names_uniprotkb": "", "gene_names_refseq": "4930579G24Rik", "protein_names_uniprotkb": "Uncharacterized protein C4orf46 homolog", "protein_names_refseq": "uncharacterized protein C4orf46 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75939)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4P8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UUX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q571C7-1", "uniprot_id": "BDP1_MOUSE", "mass": 270790.0, "length": 2467, "protein_name": "Transcription factor TFIIIB component B'' homolog", "gene_name": "Bdp1", "organism": "Mouse", "refseq_name": "transcription factor TFIIIB component B'' homolog", "refseq_ac": "NP_001074530", "gene_names_uniprotkb": "Bdp1; Kiaa1241; Tfnr", "gene_names_refseq": "B130055N23Rik; Bdp1; G630013P12Rik; TAF3B1; TFC5; TFIIIB150; TFIIIB90; Tfnr; mKIAA1241", "protein_names_uniprotkb": "Transcription factor TFIIIB component B'' homolog; TFIIIB150; Transcription factor IIIB 150; Transcription factor-like nuclear regulator", "protein_names_refseq": "transcription factor IIIB 150; transcription factor TFIIIB component B'' homolog; transcription factor-like nuclear regulator", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 112 (Disease Ontology:DOID:0111637)", "pathway": " (mmu:544971); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21750661;24312468", "class_list": "", "function": "General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site (By similarity)., [UniProtKB]; Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTI4;Q8K0U7", "ec_number_list": "", "go_molecular_function": "GO:0001156 TFIIIC-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0070898 RNA polymerase III preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q571C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61125-1", "uniprot_id": "BKRB1_MOUSE", "mass": 37886.0, "length": 334, "protein_name": "B1 bradykinin receptor", "gene_name": "Bdkrb1", "organism": "Mouse", "refseq_name": "B1 bradykinin receptor", "refseq_ac": "NP_031565", "gene_names_uniprotkb": "Bdkrb1; Bdkrb", "gene_names_refseq": "B1BKR; B1R; BKR1; BRADYB1; Bdkrb1; Bdkrb", "protein_names_uniprotkb": "B1 bradykinin receptor; B1R; BK-1 receptor", "protein_names_refseq": "B1 bradykinin receptor; BK-1 receptor; kinin B1", "tax_id": 10090, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); pleurisy (Disease Ontology:DOID:10247); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:12061); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;39017739;8602848", "class_list": "", "function": "Kinin B1 receptor deficiency promotes enhanced adipose tissue thermogenic response to beta3-adrenergic stimulation., [RefSeq, PubMed]; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1F4", "ec_number_list": "", "go_molecular_function": "GO:0042277 peptide binding;GO:0004947 bradykinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0032496 response to lipopolysaccharide;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61335-1", "uniprot_id": "BAP31_MOUSE", "mass": 27957.0, "length": 245, "protein_name": "B-cell receptor-associated protein 31", "gene_name": "Bcap31", "organism": "Mouse", "refseq_name": "B-cell receptor-associated protein 31 isoform a", "refseq_ac": "NP_001300627", "gene_names_uniprotkb": "Bcap31; Bap31", "gene_names_refseq": "Bap31; Bcap31", "protein_names_uniprotkb": "B-cell receptor-associated protein 31; BCR-associated protein 31; Bap31; p28", "protein_names_refseq": "B-cell receptor-associated protein 31 isoform a; BCR-associated protein 31; accessory protein BAP31; p28", "tax_id": 10090, "disease": "deafness, dystonia, and cerebral hypomyelination (Disease Ontology:DOID:0112123); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:27061); (R-MMU-111465); (R-MMU-75153); (R-MMU-8980692); (R-MMU-983170)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12886015;15187134;25428506;28528544;34428180;36210579;36549351;37063427;37686286;38732181;8070407;8612576;9396746", "class_list": "", "function": "A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum., [RefSeq, PubMed]; B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury., [RefSeq, PubMed]; BAP31 Knockout in Macrophages Affects CD4[+]T Cell Activation through Upregulation of MHC Class II Molecule. Publication Status: Online-Only, [RefSeq, PubMed]; BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation. Publication Status: Online-Only, [RefSeq, PubMed]; BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-kappaB pathway in acute lung injury mice model., [RefSeq, PubMed]; Functions as a chaperone protein (PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (PubMed:15187134). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (By similarity). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (By similarity). May be involved in CASP8-mediated apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALM8;Q9D0E9;Q9D8G7", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0006915 apoptotic process;GO:0006626 protein targeting to mitochondrion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q61335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62556-1", "uniprot_id": "BT1A1_MOUSE", "mass": 58407.0, "length": 524, "protein_name": "Butyrophilin subfamily 1 member A1", "gene_name": "Btn1a1", "organism": "Mouse", "refseq_name": "butyrophilin subfamily 1 member A1 precursor", "refseq_ac": "NP_038511", "gene_names_uniprotkb": "Btn1a1; Btn", "gene_names_refseq": "Btn1a1; Btn", "protein_names_uniprotkb": "Butyrophilin subfamily 1 member A1; BT", "protein_names_refseq": "BT; butyrophilin subfamily 1 member A1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:12231); (R-MMU-8851680)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20208008;21915327;8541302;8995761", "class_list": "", "function": "Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein., [RefSeq, PubMed]; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion., [UniProtKB, PubMed]; These data are consistent with a coinhibitory role for mouse Butyrophilins, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97392;Q8K2H7;Q921K7", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62556-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64373-1", "uniprot_id": "B2CL1_MOUSE", "mass": 26132.0, "length": 233, "protein_name": "Bcl-2-like protein 1", "gene_name": "Bcl2l1", "organism": "Mouse", "refseq_name": "bcl-2-like protein 1 isoform a", "refseq_ac": "NP_001276645", "gene_names_uniprotkb": "Bcl2l1; Bcl2l; Bclx", "gene_names_refseq": "Bcl(X)L; Bcl-XL; Bcl2l1; Bcl2l; BclX; bcl-x; bcl2-L-1", "protein_names_uniprotkb": "Bcl-2-like protein 1; Apoptosis regulator Bcl-X; Bcl2-L-1", "protein_names_refseq": "B-cell leukemia/lymphoma x; anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; bcl-2-like protein 1 isoform a; bcl-2-like protein 1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate carcinoma (Disease Ontology:DOID:10286); lymphoid leukemia (Disease Ontology:DOID:1037); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); dilated cardiomyopathy (Disease Ontology:DOID:12930); endometrial cancer (Disease Ontology:DOID:1380); uterus interstitial leiomyoma (Disease Ontology:DOID:13955); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); hematopoietic system disease (Disease Ontology:DOID:74); chronic myeloid leukemia (Disease Ontology:DOID:8552); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); ocular hypertension (Disease Ontology:DOID:9282); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:12048); (R-MMU-111453); (R-MMU-844455); (R-MMU-9648002)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "14499110;16509771;21502331;21750661;24808369;25876659;27013495;27218122;28958480;38786548;39285161;7607090;7963517;9144489;9390687", "class_list": "", "function": "Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of Janus kinase-dependent Bcl-xL overexpression in steroid resistance of group 2 innate lymphoid cells in asthma., [RefSeq, PubMed]; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles (By similarity). May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform Bcl-X(S) promotes apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35844;Q60657;Q60658;Q61338", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:2001171 positive regulation of ATP biosynthetic process;GO:0036466 synaptic vesicle recycling via endosome;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:2000302 positive regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q64373-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A051-1", "uniprot_id": "ATRN1_MOUSE", "mass": 152467.0, "length": 1378, "protein_name": "Attractin-like protein 1", "gene_name": "Atrnl1", "organism": "Mouse", "refseq_name": "attractin-like protein 1 precursor", "refseq_ac": "NP_852080", "gene_names_uniprotkb": "Atrnl1; Alp; Atrnl; Kiaa0534", "gene_names_refseq": "Alp; Atrnl1; Atrnlp; Atrnl", "protein_names_uniprotkb": "Attractin-like protein 1", "protein_names_refseq": "attractin-like protein 1 precursor; attractin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226255)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14531729;18064672;25428506;30084848;31599954", "class_list": "glycogene", "function": "Identification of attractin-like protein as a binding partner of melanocortin-4 receptor (attractin-like protein)., [RefSeq, PubMed]; May play a role in melanocortin signaling pathways that regulate energy homeostasis., [UniProtKB]; Over-expression of ATRNL1 compensates for loss of ATRN., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHB0;Q68HV2;Q80VI3;Q8BKS4;Q8K0P5", "ec_number_list": "", "go_molecular_function": "GO:0005112 Notch binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6A051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQU0-1", "uniprot_id": "CC070_MOUSE", "mass": 27476.0, "length": 248, "protein_name": "UPF0524 protein C3orf70 homolog", "gene_name": "2510009E07Rik", "organism": "Mouse", "refseq_name": "UPF0524 protein C3orf70 homolog", "refseq_ac": "NP_001001881", "gene_names_uniprotkb": "2510009E07Rik", "gene_names_refseq": "2510009E07Rik", "protein_names_uniprotkb": "UPF0524 protein C3orf70 homolog", "protein_names_refseq": "UPF0524 protein C3orf70 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in neuronal and neurobehavioral development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GQU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6H1V1-1", "uniprot_id": "BEST3_MOUSE", "mass": 76431.0, "length": 669, "protein_name": "Bestrophin-3", "gene_name": "Best3", "organism": "Mouse", "refseq_name": "bestrophin-3", "refseq_ac": "NP_001007584", "gene_names_uniprotkb": "Best3; Vmd2l3", "gene_names_refseq": "Best3; Vmd2l3; mBest4", "protein_names_uniprotkb": "Bestrophin-3; Vitelliform macular dystrophy 2-like protein 3", "protein_names_refseq": "bestrophin-3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like protein 3", "tax_id": 10090, "disease": "aortic dissection (Disease Ontology:DOID:0080685)", "pathway": " (mmu:382427); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15218265;16563389;17442670;18414923;25329324;25912364;27265833;37203562", "class_list": "", "function": "Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection., [RefSeq, PubMed]; Does not function as calcium-gated chloride channel., [UniProtKB, PubMed]; Ligand-gated anion channel that allows the movement of chloride monoatomic anions across cell membranes when activated by calcium (Ca2+)., [UniProtKB, PubMed]; Our experiments present clear evidence of Best3 mRNA and protein expression in mouse kidney glomeruli, [RefSeq, PubMed]; Results demonstrated that Best-3 is an endogenous inhibitor of NF-kappaB signaling pathway in endothelial cells, suggesting that forced Best-3 expression may be a novel approach for the treatment of vascular inflammatory diseases. Publication Status: Online-Only, [RefSeq, PubMed]; The authors propose that Best3V2 isoform in myoblasts may work as a tuner to control Ca(2+) release from intracellular Ca(2+) stores. Publication Status: Online-Only, [RefSeq, PubMed]; The channel activity of the mBest4 protein lacking the C-terminus (residues 353-669) was specifically inhibited by co-expression of C-terminal fragments of mBest4 having the inhibitory motif. Erratum:[FEBS Lett. 2007 Feb 6;581(3):580], [RefSeq, PubMed]; These results suggest that an auto-inhibitory mechanism in C termini of bestrophin 3 may be universal among bestrophins investigated in the study., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0099095 ligand-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0015698 inorganic anion transport;GO:0043271 negative regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6H1V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P2L7-1", "uniprot_id": "GOLM2_MOUSE", "mass": 49409.0, "length": 435, "protein_name": "Protein GOLM2", "gene_name": "Golm2", "organism": "Mouse", "refseq_name": "protein GOLM2 isoform 3", "refseq_ac": "NP_001192298", "gene_names_uniprotkb": "Golm2; Casc4", "gene_names_refseq": "Casc4; D130060C09Rik; Golm2; VGFG2573", "protein_names_uniprotkb": "Protein GOLM2; CASC4; Cancer susceptibility candidate gene 4 protein homolog; Golgi membrane protein 2", "protein_names_refseq": "cancer susceptibility candidate 4; cancer susceptibility candidate gene 4 protein homolog; protein CASC4; protein GOLM2 isoform 3; protein GOLM2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319996)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AR57;Q6RZW5;Q6RZW6;Q8C4Z2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P2L7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M757-1", "uniprot_id": "BRC3L_MOUSE", "mass": 33079.0, "length": 291, "protein_name": "Lys-63-specific deubiquitinase BRCC36-like", "gene_name": "Brcc3dc", "organism": "Mouse", "refseq_name": "lys-63-specific deubiquitinase BRCC36-like", "refseq_ac": "NP_988991", "gene_names_uniprotkb": "Brcc3dc; C6.1al; Gm5136", "gene_names_refseq": "Brcc3dc; C6.1AL; EG368203; Gm5136", "protein_names_uniprotkb": "Lys-63-specific deubiquitinase BRCC36-like; 3.4.19.-; BRCA1/BRCA2-containing complex subunit 3-like", "protein_names_refseq": "BRCA1/BRCA2-containing complex subunit 3-like; lys-63-specific deubiquitinase BRCC36-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:368203)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12838346", "class_list": "", "function": "Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY45", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0044546 NLRP3 inflammasome complex assembly;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M757-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TST0-1", "uniprot_id": "BTNL1_MOUSE", "mass": 57726.0, "length": 509, "protein_name": "Butyrophilin-like protein 1", "gene_name": "Btnl1", "organism": "Mouse", "refseq_name": "butyrophilin-like protein 1 precursor", "refseq_ac": "NP_001104564", "gene_names_uniprotkb": "Btnl1; Btnl3; Gm316; Ng10", "gene_names_refseq": "Btnl1; Btnl3; Gm316; Gm33", "protein_names_uniprotkb": "Butyrophilin-like protein 1", "protein_names_refseq": "NG10; butyrophilin-like 3; butyrophilin-like protein 1 precursor; butyrophilin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100038862)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20944003;21368163;27528202", "class_list": "", "function": "BTNL1 is a critical inhibitory molecule for T cell activation and immune diseases., [RefSeq, PubMed]; Data show that the expression of Btnl1 and Btnl6 is delayed in the murine neonatal gut and that the appearance of the Btnl1 and Btnl6 proteins in the intestinal mucosa associates with the expansion of Vgamma7Vdelta4 TCR IELs Publication Status: Online-Only, [RefSeq, PubMed]; Enforced epithelial cell expression of Btnl1 attenuated the cells' response to activated intraepithelial lymphocyte, as evidenced by suppression of IL-6 and other inflammatory mediators., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6X8K2;G3UZN0;O70356", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045062 extrathymic T cell selection;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TST0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TT2-2", "uniprot_id": "BAIP3_MOUSE", "mass": 129069.0, "length": 1150, "protein_name": "BAI1-associated protein 3", "gene_name": "Baiap3", "organism": "Mouse", "refseq_name": "BAI1-associated protein 3", "refseq_ac": "NP_001156742", "gene_names_uniprotkb": "Baiap3; Gm937; Kiaa0734", "gene_names_refseq": "Baiap3; Bap3; Gm937", "protein_names_uniprotkb": "BAI1-associated protein 3; BAP3; Baiap3; Brain-specific angiogenesis inhibitor I-associated protein 3", "protein_names_refseq": "BAI1-associated protein 3; brain-specific angiogenesis inhibitor I-associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:545192)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12498718;23698091;31219806", "class_list": "", "function": "Baiap3 is gender specifically associated with anxiety and benzodiazepine use disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (By similarity). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ76;Q6RUT4;S4R1E7", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050795 regulation of behavior;GO:0050804 modulation of chemical synaptic transmission;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80TT2-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UY1-1", "uniprot_id": "CARME_MOUSE", "mass": 46339.0, "length": 400, "protein_name": "Protein-L-histidine N-pros-methyltransferase CARNMT1", "gene_name": "Carnmt1", "organism": "Mouse", "refseq_name": "carnosine N-methyltransferase isoform 1", "refseq_ac": "NP_080396", "gene_names_uniprotkb": "Carnmt1", "gene_names_refseq": "2410127L17Rik; Carnmt1", "protein_names_uniprotkb": "Protein-L-histidine N-pros-methyltransferase CARNMT1; 2.1.1.-; 2.1.1.22; Carnosine N-methyltransferase", "protein_names_refseq": "UPF0586 protein C9orf41 homolog; carnosine N-methyltransferase isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67383); (R-MMU-70921)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;37612136", "class_list": "", "function": "Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism., [RefSeq, PubMed]; Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover (PubMed:37612136). Additionally, it methylates the dipeptide carnosine (beta-alanyl-L-histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle. Acts also on other L-histidine-containing di- and tripeptides, such as Gly-Gly-His, Gly-His, and homocarnosine (GABA-His) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWF3", "ec_number_list": "2.1.1.-;2.1.1.22", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0030735 carnosine N-methyltransferase activity;GO:0106370 protein-L-histidine N-pros-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0035498 carnosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80UY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V42-1", "uniprot_id": "CBPM_MOUSE", "mass": 50556.0, "length": 443, "protein_name": "Carboxypeptidase M", "gene_name": "Cpm", "organism": "Mouse", "refseq_name": "carboxypeptidase M precursor", "refseq_ac": "NP_081744", "gene_names_uniprotkb": "Cpm", "gene_names_refseq": "1110060I01Rik; 5730456K23Rik; Cpm; E030045M14Rik", "protein_names_uniprotkb": "Carboxypeptidase M; 3.4.17.12; CPM", "protein_names_refseq": "carboxypeptidase M precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:70574); (R-MMU-163125)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;18844448;19200403;30899004;33300544;40885482", "class_list": "", "function": "Of the 33 transcripts from the CPM locus, four were evaluated with one showing expression patterns that differed considerably from the other ones and from the mouse CPM gene, suggesting that there may be more than one transcriptional unit in this locus Publication Status: Online-Only, [RefSeq, PubMed]; Spatial proximity between angiotensin-converting enzyme and the endogenous CPM enables an angiotensin-converting enzyme evoked release of CPM, [RefSeq, PubMed]; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q497S5;Q9CYH8", "ec_number_list": "3.4.11.9;3.1.3.1;3.1.4.50;3.9.1.1;3.2.2.6;3.4.17.12;2.4.2.31;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q80V42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YW5-1", "uniprot_id": "BSPRY_MOUSE", "mass": 52751.0, "length": 473, "protein_name": "B box and SPRY domain-containing protein", "gene_name": "Bspry", "organism": "Mouse", "refseq_name": "B box and SPRY domain-containing protein isoform 1", "refseq_ac": "NP_619594", "gene_names_uniprotkb": "Bspry", "gene_names_refseq": "Bspry", "protein_names_uniprotkb": "B box and SPRY domain-containing protein", "protein_names_refseq": "B box and SPRY domain-containing protein isoform 1; b box and SPRY domain-containing protein; zetin 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192120)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10978534;12615066;16380433;21750661;22972184;32181567", "class_list": "", "function": "Associated with both embryonic stem cell pluripotency and early embryonic development, [RefSeq, PubMed]; CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases., [RefSeq, PubMed]; May regulate epithelial calcium transport by inhibiting TRPV5 activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU74;Q8BZF0;Q99KV7;Q9ER70", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0006816 calcium ion transport;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80YW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUG5-1", "uniprot_id": "CAYP2_MOUSE", "mass": 62726.0, "length": 550, "protein_name": "Calcyphosin-2", "gene_name": "Caps2", "organism": "Mouse", "refseq_name": "calcyphosin-2 isoform 2", "refseq_ac": "NP_001297604", "gene_names_uniprotkb": "Caps2", "gene_names_refseq": "Caps2; D630005B03Rik", "protein_names_uniprotkb": "Calcyphosin-2; Calcyphosine-2", "protein_names_refseq": "calcyphosin-2 isoform 2; calcyphosin-2; calcyphosine 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:353025)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11846421;19238500;20302894;21173225;22111578;25437547;25754523;28963059;30389842;33846232", "class_list": "", "function": "CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis, [RefSeq, PubMed]; CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior., [RefSeq, PubMed]; CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders Review article, [RefSeq, PubMed]; CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks., [RefSeq, PubMed]; Discusses cloning of the human homolog of mouse Caps2 (GeneID: 353025)., [RefSeq, PubMed]; Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release, [RefSeq, PubMed]; Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain., [RefSeq, PubMed]; That CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons, [RefSeq, PubMed]; The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development. Review article, [RefSeq, PubMed]; These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2J8;G3X9M5;Q8C1J6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0016358 dendrite development;GO:0050808 synapse organization;GO:0035176 social behavior;GO:0009306 protein secretion;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BUG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1Y8-1", "uniprot_id": "CCZ1_MOUSE", "mass": 55505.0, "length": 480, "protein_name": "Vacuolar fusion protein CCZ1 homolog", "gene_name": "Ccz1", "organism": "Mouse", "refseq_name": "vacuolar fusion protein CCZ1 homolog isoform 1", "refseq_ac": "NP_808350", "gene_names_uniprotkb": "Ccz1", "gene_names_refseq": "Ccz1", "protein_names_uniprotkb": "Vacuolar fusion protein CCZ1 homolog", "protein_names_refseq": "CCZ1 vacuolar protein trafficking and biogenesis associated homolog; vacuolar fusion protein CCZ1 homolog isoform 1; vacuolar fusion protein CCZ1 homolog", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:231874); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19144319;20305638;21183079;21952136;25428507;25605945;34428180;35820727", "class_list": "", "function": "Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form., [UniProtKB, UniProtKB]; Data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses [ccz1], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U891", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005770 late endosome;GO:0035658 Mon1-Ccz1 complex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C1Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C726-1", "uniprot_id": "BTBD9_MOUSE", "mass": 69148.0, "length": 612, "protein_name": "BTB/POZ domain-containing protein 9", "gene_name": "Btbd9", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 9", "refseq_ac": "NP_081336", "gene_names_uniprotkb": "Btbd9", "gene_names_refseq": "1700023F20Rik; 4930402L05; Btbd9", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 9", "protein_names_refseq": "BTB (POZ) domain containing 9; BTB/POZ domain-containing protein 9", "tax_id": 10090, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425)", "pathway": " (mmu:224671)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18363860;21750661;22658601;32446853;32468214;34428180;36244636", "class_list": "", "function": "BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome., [RefSeq, PubMed]; Further Studies on the Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome., [RefSeq, PubMed]; In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis Review article, [RefSeq, PubMed]; The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0042428 serotonin metabolic process;GO:0050804 modulation of chemical synaptic transmission;GO:0007616 long-term memory;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI61-1", "uniprot_id": "BAG4_MOUSE", "mass": 49095.0, "length": 457, "protein_name": "BAG family molecular chaperone regulator 4", "gene_name": "Bag4", "organism": "Mouse", "refseq_name": "BAG family molecular chaperone regulator 4", "refseq_ac": "NP_080397", "gene_names_uniprotkb": "Bag4; Sodd", "gene_names_refseq": "2410112I15Rik; Bag4; SODD", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains", "protein_names_refseq": "BAG family molecular chaperone regulator 4; BAG-4; bcl-2-associated athanogene 4; silencer of death domains", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:67384); (R-MMU-3371453); (R-MMU-75893)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11909948;12706861;12748303;14559896;16799968;21712384;22872234;24129315;25428506;30084848;31219806;34428180;36210013;37107587", "class_list": "", "function": "BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing, [RefSeq, PubMed]; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity)., [UniProtKB]; Results suggest that silencer of death domains protein (SODD) is critical for the regulation of tumor necrosis factor signaling., [RefSeq, PubMed]; SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals, [RefSeq, PubMed]; Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton., [RefSeq, PubMed]; The proapoptotic proteins Bak (Bcl-2 antagonistic killer) and Bax (Bcl-2-associated X protein) were depleted in livers from TCPOBOP-treated CAR+/+ mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRL9;Q91VT5;Q9CWG2", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045785 positive regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0072659 protein localization to plasma membrane;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CI61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2J9-2", "uniprot_id": "BTBD6_MOUSE", "mass": 59100.0, "length": 539, "protein_name": "BTB/POZ domain-containing protein 6", "gene_name": "Btbd6", "organism": "Mouse", "refseq_name": "BTB/POZ domain-containing protein 6 isoform 2", "refseq_ac": "NP_001139372", "gene_names_uniprotkb": "Btbd6", "gene_names_refseq": "Btbd6", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 6", "protein_names_refseq": "BTB (POZ) domain containing 6; BTB/POZ domain-containing protein 6 isoform 2; BTB/POZ domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:399566); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIB3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2J9-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2G6-1", "uniprot_id": "CCD80_MOUSE", "mass": 107613.0, "length": 949, "protein_name": "Coiled-coil domain-containing protein 80", "gene_name": "Ccdc80", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 80 precursor", "refseq_ac": "NP_080715", "gene_names_uniprotkb": "Ccdc80; Urb", "gene_names_refseq": "2610001E17Rik; Ccdc80; DRO1; Ssg1; Urb", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 80; Up-regulated in BRS-3 deficient mouse", "protein_names_refseq": "coiled-coil domain-containing protein 80 precursor; coiled-coil domain-containing protein 80; steroid sensitive gene 1; up-regulated in BRS-3 deficient mouse", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:67896)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11812002;15325258;18178152;18757743;29901779;30439364;34418053", "class_list": "", "function": "Downregulated during osteoblastic differentiation of bone marrow stromal cells. Suggests role in skeletogenesis., [RefSeq, PubMed]; Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a., [RefSeq, PubMed]; In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes., [RefSeq, PubMed]; Promotes cell adhesion and matrix assembly., [UniProtKB, PubMed]; The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1A4B0;Q3V1Y4;Q4VA97;Q6PDE5;Q8C043;Q9CRM1;Q9CT39;Q9D6Z4", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0001968 fibronectin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0009617 response to bacterium;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R2G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R422-1", "uniprot_id": "CD109_MOUSE", "mass": 161659.0, "length": 1442, "protein_name": "CD109 antigen", "gene_name": "Cd109", "organism": "Mouse", "refseq_name": "CD109 antigen precursor", "refseq_ac": "NP_694738", "gene_names_uniprotkb": "Cd109", "gene_names_refseq": "9930012E15Rik; Cd109; GARP", "protein_names_uniprotkb": "CD109 antigen; GPI-anchored alpha-2 macroglobulin-related protein", "protein_names_refseq": "CD109 antigen precursor; GPI-anchored alpha 2 macroglobulin-related protein; Gov platelet alloantigens", "tax_id": 10090, "disease": "", "pathway": " (mmu:235505); (R-MMU-114608); (R-MMU-163125)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;22846721;23436317;28011936;34428180;34887587;37828378;38334455;38796094", "class_list": "", "function": "Asporin and CD109, expressed in the injured neonatal spinal cord, attenuate axonal re-growth in vitro., [RefSeq, PubMed]; CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-beta Signaling., [RefSeq, PubMed]; CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma., [RefSeq, PubMed]; CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3., [RefSeq, PubMed]; Modulates negatively TGFB1 signaling in keratinocytes., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLT6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0061045 negative regulation of wound healing;GO:0001942 hair follicle development;GO:0010839 negative regulation of keratinocyte proliferation;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDP4-1", "uniprot_id": "CCAR2_MOUSE", "mass": 103002.0, "length": 922, "protein_name": "Cell cycle and apoptosis regulator protein 2", "gene_name": "Ccar2", "organism": "Mouse", "refseq_name": "cell cycle and apoptosis regulator protein 2", "refseq_ac": "NP_666167", "gene_names_uniprotkb": "Ccar2", "gene_names_refseq": "2610301G19Rik; Ccar2; Dbc1; mKIAA1967", "protein_names_uniprotkb": "Cell cycle and apoptosis regulator protein 2; Cell division cycle and apoptosis regulator protein 2", "protein_names_refseq": "cell cycle and apoptosis regulator protein 2; cell division cycle and apoptosis regulator protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:219158)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "15345747;17242355;19218236;21030595;21183079;23398316;24415752;25732823;29187734;31219806;31361958;32317757;34197713;34428180;34887587;35820727;37683133;38062876;39627609", "class_list": "", "function": "Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1., [RefSeq, PubMed]; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (By similarity). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (By similarity). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (By similarity). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (By similarity). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (By similarity). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (By similarity). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting., [RefSeq, PubMed]; SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells., [RefSeq, PubMed]; The protein Deleted in Breast Cancer-1 (DBC1) regulates vascular response and formation of aortic dissection during Angiotensin II infusion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PIB1;Q8BWR5;Q8C0F0;Q8R3G6", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0000993 RNA polymerase II complex binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005819 spindle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0043065 positive regulation of apoptotic process;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8VDP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE99-1", "uniprot_id": "VMA22_MOUSE", "mass": 19743.0, "length": 180, "protein_name": "Vacuolar ATPase assembly protein VMA22", "gene_name": "Vma22", "organism": "Mouse", "refseq_name": "vacuolar ATPase assembly protein VMA22", "refseq_ac": "NP_081435", "gene_names_uniprotkb": "Vma22; Ccdc115", "gene_names_refseq": "2310061I09Rik; Ccdc115; Ccp1; Vma22", "protein_names_uniprotkb": "Vacuolar ATPase assembly protein VMA22; Ccp1; Coiled-coil domain-containing protein 115; Coiled-coil protein 1", "protein_names_refseq": "coiled-coil domain containing 115; coiled-coil domain-containing protein 115; coiled-coil protein 1; vacuolar ATPase assembly protein VMA22", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIo (Disease Ontology:DOID:0070267)", "pathway": " (mmu:69668); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16378758;21118521;31219806", "class_list": "", "function": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity)., [UniProtKB, UniProtKB]; Ccp1 regulates cell number by promoting proliferation and suppressing cell death. FGF2 was shown to enhance the effects of ccp1, however, it is likely that other mitogenic factors present in the serum can also enhance the effects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS67", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007042 lysosomal lumen acidification;GO:0036295 cellular response to increased oxygen levels;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VE99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VED2-1", "uniprot_id": "BL1S4_MOUSE", "mass": 23112.0, "length": 215, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 4", "gene_name": "Bloc1s4", "organism": "Mouse", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 4", "refseq_ac": "NP_598485", "gene_names_uniprotkb": "Bloc1s4; Cno", "gene_names_refseq": "2610101N07Rik; Bloc1s4; Blos4; Cno", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 4; BLOC-1 subunit 4; Protein cappuccino homolog", "protein_names_refseq": "BLOC-1 subunit 4; biogenesis of lysosome-related organelles complex 1 subunit 4; biogenesis of organelles complex-1, subunit 4, cappuccino; cappuccino; protein cappuccino homolog", "tax_id": 10090, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:117197); (R-MMU-432722)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11110696;12576321;16760431;16948132;19546860;21998198", "class_list": "", "function": "Coassembles with pallidin and the muted protein in the BLOC-1 complex, [RefSeq, PubMed]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking., [UniProtKB, PubMed, PubMed, PubMed]; Genetic analysis revealed a deleterious mutation in the cappuccino gene (cno), which is profoundly involved in platelet function in the progression of immune complex crescentic glomerulonephritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0031175 neuron projection development;GO:0050885 neuromuscular process controlling balance;GO:0070527 platelet aggregation;GO:0008089 anterograde axonal transport;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VED2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X34-1", "uniprot_id": "BAAT_MOUSE", "mass": 46482.0, "length": 420, "protein_name": "Bile acid-CoA:amino acid N-acyltransferase", "gene_name": "Baat", "organism": "Mouse", "refseq_name": "bile acid-CoA:amino acid N-acyltransferase", "refseq_ac": "NP_031545", "gene_names_uniprotkb": "Baat", "gene_names_refseq": "BAT; Baat", "protein_names_uniprotkb": "Bile acid-CoA:amino acid N-acyltransferase; 2.3.1.65; 3.1.2.27; 3.1.2.2; BACAT; BAT; Bile acid-CoA thioesterase; Choloyl-CoA hydrolase; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase", "protein_names_refseq": "BACAT; bile acid-CoA thioesterase; bile acid-CoA:amino acid N-acyltransferase; bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase; choloyl-CoA hydrolase; glycine N-choloyltransferase; long-chain fatty-acyl-CoA hydrolase; taurine N-acyltransferase", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); familial hypercholanemia 3 (Disease Ontology:DOID:0061180)", "pathway": " (mmu:12012); (R-MMU-159418); (R-MMU-193368); (R-MMU-9033241)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12810727;23806337;34428180;37453647;9215542", "class_list": "", "function": "Catalyzes the amidation of bile acids (BAs) with the amino acid taurine (PubMed:9215542). Selective for taurine conjugation of cholyl CoA and only taurine-conjugated BAs are found in bile (PubMed:9215542). Amidation of BAs in the liver with taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKK7;O08833;Q8C1I3", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;3.1.2.2;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.22;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;7.6.2.-;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;2.3.1.42;3.5.2.6;2.3.1.9;1.5.3.13;3.1.2.14;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0033882 choloyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052815 medium-chain fatty acyl-CoA hydrolase activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006699 bile acid biosynthetic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91X34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z92-1", "uniprot_id": "B3GT6_MOUSE", "mass": 37021.0, "length": 325, "protein_name": "Beta-1,3-galactosyltransferase 6", "gene_name": "B3galt6", "organism": "Mouse", "refseq_name": "beta-1,3-galactosyltransferase 6 precursor", "refseq_ac": "NP_536693", "gene_names_uniprotkb": "B3galt6", "gene_names_refseq": "B3galt6; GalTII", "protein_names_uniprotkb": "Beta-1,3-galactosyltransferase 6; 2.4.1.134; Beta-1,3-GalTase 6; Beta3Gal-T6; Beta3GalT6; GAG GalTII; Galactosyltransferase II; Galactosylxylosylprotein 3-beta-galactosyltransferase; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6", "protein_names_refseq": "GAG GalTII; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6; beta-1,3-GalTase 6; beta-1,3-galactosyltransferase 6 precursor; beta-1,3-galactosyltransferase 6; beta3Gal-T6; beta3GalT6; galactosyltransferase II; galactosylxylosylprotein 3-beta-galactosyltransferase", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome spondylodysplastic type 2 (Disease Ontology:DOID:0050802); spondyloepimetaphyseal dysplasia with joint laxity type 1 (Disease Ontology:DOID:0112198); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (mmu:117592); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11551958;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC93", "ec_number_list": "2.4.1.134", "go_molecular_function": "GO:0035250 UDP-galactosyltransferase activity;GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91Z92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920V1-1", "uniprot_id": "B3GL1_MOUSE", "mass": 39371.0, "length": 331, "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1", "gene_name": "B3galnt1", "organism": "Mouse", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1", "refseq_ac": "NP_064410", "gene_names_uniprotkb": "B3galnt1; B3galt3; B3gt3; Mbrn1", "gene_names_refseq": "B3galnt1; B3galt3; Mbrn 1; b3GT3; b3Gal-T3; beta-3-Gx-T3; beta3GalT3", "protein_names_uniprotkb": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; 2.4.1.79; Beta-1,3-GalNAc-T1; Beta-1,3-GalTase 3; Beta-1,3-galactosyltransferase 3; Beta-3-Gx-T3; Beta3Gal-T3; Beta3GalT3; Brainiac 1; Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; Globoside synthase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; b3Gal-T3", "protein_names_refseq": "Brainiac 1; Globoside blood group; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase III; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3; UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; beta-1,3-GalNAc-T1; beta-1,3-GalTase 3; beta-1,3-galactosyltransferase 3; galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; globoside synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:26879); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11463849;16079416;30899004;31219806;9417047", "class_list": "glycogene;glycosyltransferase", "function": "Gb3 and Gb4 synthase are responsible for the expression of globo-series glycolipids, [RefSeq, PubMed]; Transfers N-acetylgalactosamine onto globotriaosylceramide (PubMed:9417047). Plays a critical role in preimplantation stage embryonic development (PubMed:11463849)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54906;Q91V72;Q920V0;Q9CTE5", "ec_number_list": "2.4.1.79", "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q920V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M08-1", "uniprot_id": "SRALN_MOUSE", "mass": 7404.0, "length": 65, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN", "gene_name": "Arln", "organism": "Mouse", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN", "refseq_ac": "NP_077781", "gene_names_uniprotkb": "Arln; Aln", "gene_names_refseq": "1810037I17Rik; 5730414I01Rik; Aln; Arln", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN; ALN; Allregulin; Another-regulin; SERCA regulator ARLN", "protein_names_refseq": "SERCA regulator ALN; SERCA regulator ARLN; another-regulin; sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ALN; sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN; uncharacterized protein C4orf3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67704)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17208939;19144319;27923914;31449798", "class_list": "", "function": "Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEY1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99M08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N20-1", "uniprot_id": "BRMS1_MOUSE", "mass": 28210.0, "length": 246, "protein_name": "Breast cancer metastasis-suppressor 1 homolog", "gene_name": "Brms1", "organism": "Mouse", "refseq_name": "breast cancer metastasis-suppressor 1 homolog isoform 1", "refseq_ac": "NP_598916", "gene_names_uniprotkb": "Brms1", "gene_names_refseq": "Brms1", "protein_names_uniprotkb": "Breast cancer metastasis-suppressor 1 homolog", "protein_names_refseq": "breast cancer metastasis-suppressor 1 homolog isoform 1; breast cancer metastasis-suppressor 1 homolog", "tax_id": 10090, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)", "pathway": " (mmu:107392); (R-MMU-3214815)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11774238;12115030;21750661", "class_list": "", "function": "Comparative sequence analysis in eight inbred strains, [RefSeq, PubMed]; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070822 Sin3-type complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQH7-1", "uniprot_id": "BT3L4_MOUSE", "mass": 17271.0, "length": 158, "protein_name": "Transcription factor BTF3 homolog 4", "gene_name": "Btf3l4", "organism": "Mouse", "refseq_name": "transcription factor BTF3 homolog 4 isoform 1", "refseq_ac": "NP_081729", "gene_names_uniprotkb": "Btf3l4", "gene_names_refseq": "4632412E09Rik; 5730434I03Rik; Btf3l4", "protein_names_uniprotkb": "Transcription factor BTF3 homolog 4; Basic transcription factor 3-like 4", "protein_names_refseq": "transcription factor BTF3 homolog 4 isoform 1; transcription factor BTF3 homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:70533)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "28011936;34428180;35984892;37828378", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRC6-1", "uniprot_id": "BORC7_MOUSE", "mass": 11546.0, "length": 105, "protein_name": "BLOC-1-related complex subunit 7", "gene_name": "Borcs7", "organism": "Mouse", "refseq_name": "BLOC-1-related complex subunit 7", "refseq_ac": "NP_079839", "gene_names_uniprotkb": "Borcs7", "gene_names_refseq": "2010012O05Rik; 4930569L17Rik; Borcs7", "protein_names_uniprotkb": "BLOC-1-related complex subunit 7", "protein_names_refseq": "BLOC-1-related complex subunit 7; UPF0693 protein C10orf32 homolog", "tax_id": 10090, "disease": "neuroaxonal dystrophy (Disease Ontology:DOID:2367); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:66439)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;30067980", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, UniProtKB]; Truncated Borcs7 reduces lysosomal transport in neurons and causes progressive axonal dystrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005764 lysosome;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex", "go_biological_process": "GO:0050905 neuromuscular process;GO:0016192 vesicle-mediated transport;GO:0051036 regulation of endosome size;GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CRC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CVN6-1", "uniprot_id": "CBY3_MOUSE", "mass": 26690.0, "length": 235, "protein_name": "Sperm annulus positioning complex subunit Chibby3", "gene_name": "Cby3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cby3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm annulus positioning complex subunit Chibby3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76653)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38197861", "class_list": "", "function": "Plays a key role in the correct positioning of the annulus, a septin-based ring strucure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CIBAR1 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCA8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097227 sperm annulus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CVN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWT2-1", "uniprot_id": "BEX4_MOUSE", "mass": 13820.0, "length": 118, "protein_name": "Protein BEX4", "gene_name": "Bex4", "organism": "Mouse", "refseq_name": "protein BEX4", "refseq_ac": "NP_997622", "gene_names_uniprotkb": "Bex4", "gene_names_refseq": "Bex4", "protein_names_uniprotkb": "Protein BEX4; Brain-expressed X-linked protein 4", "protein_names_refseq": "BEX1-like protein 1; brain expressed gene 4; brain-expressed X-linked protein 4 homolog; protein BEX4", "tax_id": 10090, "disease": "", "pathway": " (mmu:406217)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15958283;28145533;34562363", "class_list": "", "function": "May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0042826 histone deacetylase binding;GO:0043014 alpha-tubulin binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0042127 regulation of cell population proliferation;GO:0007346 regulation of mitotic cell cycle;GO:0030334 regulation of cell migration;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CWT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCA7-1", "uniprot_id": "CALY_MOUSE", "mass": 24580.0, "length": 226, "protein_name": "Neuron-specific vesicular protein calcyon", "gene_name": "Caly", "organism": "Mouse", "refseq_name": "neuron-specific vesicular protein calcyon", "refseq_ac": "NP_001177314", "gene_names_uniprotkb": "Caly; Drd1ip", "gene_names_refseq": "0710001P07Rik; 1110004A22Rik; Calcyon; Caly; Drd1ip", "protein_names_uniprotkb": "Neuron-specific vesicular protein calcyon", "protein_names_refseq": "D1 dopamine receptor-interacting protein; calcyon; dopamine receptor D1 interacting protein; neuron-specific vesicular protein calcyon", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:68566)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12853145;16595675;18295356;19120439;21403673;22650988;28734834;30084848;30753204", "class_list": "", "function": "Data suggest that upregulation of calcyon in forebrain could increase BP via alterations in noradrenergic transmission and increased oxidative stress during high salt challenge. Publication Status: Online-Only, [RefSeq, PubMed]; Endocytic and cargo sorting functions of Caly in neurons, [RefSeq, PubMed]; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis., [UniProtKB]; Taken together, the present studies involving biochemical, immunological and electrophysiological analyses raise the possibility that calcyon plays a specialized role in regulating activity-dependent removal of synaptic AMPARs., [RefSeq, PubMed]; The data of this study suggested that calcyon directly interacts with mu3A and mu3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes., [RefSeq, PubMed]; The resultd of this study showed that with calcyon-overexpressing Cal(OE) transgenic mice that lifelong calcyon upregulation impairs executive functions including response inhibition and working memory., [RefSeq, PubMed]; Transgenic mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1K9", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0016197 endosomal transport;GO:0008089 anterograde axonal transport;GO:0048268 clathrin coat assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DCA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCC3-1", "uniprot_id": "CC107_MOUSE", "mass": 26579.0, "length": 242, "protein_name": "Coiled-coil domain-containing protein 107", "gene_name": "Ccdc107", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 107 precursor", "refseq_ac": "NP_001033002", "gene_names_uniprotkb": "Ccdc107", "gene_names_refseq": "1110032O22Rik; Ccdc107", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 107", "protein_names_refseq": "coiled-coil domain-containing protein 107 precursor; coiled-coil domain-containing protein 107", "tax_id": 10090, "disease": "", "pathway": " (mmu:622404)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIN4;Q9CTB6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DCC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER42-1", "uniprot_id": "BARX1_MOUSE", "mass": 27282.0, "length": 254, "protein_name": "Homeobox protein BarH-like 1", "gene_name": "Barx1", "organism": "Mouse", "refseq_name": "homeobox protein BarH-like 1", "refseq_ac": "NP_031552", "gene_names_uniprotkb": "Barx1", "gene_names_refseq": "Barx1", "protein_names_uniprotkb": "Homeobox protein BarH-like 1", "protein_names_refseq": "homeobox protein BarH-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12022)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15809042;17855428;36210013;7669690", "class_list": "", "function": "Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09066;P70159;Q0VF04;Q9ERV2", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0030855 epithelial cell differentiation;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ER42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIB6-1", "uniprot_id": "BIR1F_MOUSE", "mass": 159866.0, "length": 1403, "protein_name": "Baculoviral IAP repeat-containing protein 1f", "gene_name": "Naip6", "organism": "Mouse", "refseq_name": "baculoviral IAP repeat-containing protein 1f", "refseq_ac": "NP_035001", "gene_names_uniprotkb": "Naip6; Birc1f; Naip-rs4", "gene_names_refseq": "Birc1f; Naip-rs4A; Naip-rs4; Naip6", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 1f; Neuronal apoptosis inhibitory protein 6", "protein_names_refseq": "baculoviral IAP repeat-containing protein 1f; neuronal apoptosis inhibitory protein 6; neuronal apoptosis inhibitory protein, related sequence 4", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (mmu:17952)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10958627;12526741;21874021;30084848;30779550;34428180;35820727;8975718", "class_list": "", "function": "Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (PubMed:21874021). The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09121;O09122;P81704;Q8CH68", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JIB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R224-1", "uniprot_id": "BEX1_MOUSE", "mass": 15119.0, "length": 128, "protein_name": "Protein BEX1", "gene_name": "Bex1", "organism": "Mouse", "refseq_name": "protein BEX1", "refseq_ac": "NP_033078", "gene_names_uniprotkb": "Bex1; Rex3", "gene_names_refseq": "Bex1; Bex2; Bex4; Rex3", "protein_names_uniprotkb": "Protein BEX1; Brain-expressed X-linked protein 1 homolog; REX-3; Reduced expression protein 3", "protein_names_refseq": "REX-3; brain expressed gene 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; protein BEX1; protein BEX2; reduced expression 3; reduced expression protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:19716)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10072429;11835573;11989783;12054873;12911636;15198671;15861462;34562363;35144600;37715024;9806360", "class_list": "", "function": "BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARgamma/PDK1 dependent manner., [RefSeq, PubMed]; Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter molecule involved in p75NTR/NGFR signaling (By similarity). Plays a role in cell cycle progression and neuronal differentiation (By similarity). Inhibits neuronal differentiation in response to nerve growth factor (NGF) (By similarity). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363)., [UniProtKB, UniProtKB, PubMed]; Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos. Erratum:[Mol Reprod Dev. 2002 Sep;63(1):141.], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGA2;O88858;Q9R1J2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0001223 transcription coactivator binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007165 signal transduction;GO:0045665 negative regulation of neuron differentiation;GO:0031397 negative regulation of protein ubiquitination;GO:0048011 neurotrophin TRK receptor signaling pathway;GO:0002052 positive regulation of neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0L4-1", "uniprot_id": "BMP15_MOUSE", "mass": 44898.0, "length": 392, "protein_name": "Bone morphogenetic protein 15", "gene_name": "Bmp15", "organism": "Mouse", "refseq_name": "bone morphogenetic protein 15 preproprotein", "refseq_ac": "NP_033887", "gene_names_uniprotkb": "Bmp15; Gdf9b", "gene_names_refseq": "Bmp-15; Bmp15; GDF-9B", "protein_names_uniprotkb": "Bone morphogenetic protein 15; BMP-15; GDF-9B; Growth/differentiation factor 9B", "protein_names_refseq": "bone morphogenetic protein 15 preproprotein; growth/differentiation factor 9B", "tax_id": 10090, "disease": "ovarian dysgenesis 2 (Disease Ontology:DOID:0080494); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:12155); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10612437;33824958;9849956;9858711", "class_list": "", "function": "Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytesdagger. Erratum:[Biol Reprod. 2021 Oct 11;105(4):1069. doi: 10.1093/biolre/ioab154. PMID: 34390336], [RefSeq, PubMed]; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity)., [UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Female mice lacking a functional copy of this gene exhibit impaired fertility. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT46", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z0L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z121-1", "uniprot_id": "CCL8_MOUSE", "mass": 11017.0, "length": 97, "protein_name": "C-C motif chemokine 8", "gene_name": "Ccl8", "organism": "Mouse", "refseq_name": "C-C motif chemokine 8 precursor", "refseq_ac": "NP_067418", "gene_names_uniprotkb": "Ccl8; Mcp2; Scya8", "gene_names_refseq": "1810063B20Rik; Ccl8; HC14; MCP-2; Mcp2; Scya8", "protein_names_uniprotkb": "C-C motif chemokine 8; MCP-2; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; Small-inducible cytokine A8", "protein_names_refseq": "C-C motif chemokine 8 precursor; C-C motif chemokine 8; chemokine (C-C motif) ligand 8; monocyte chemoattractant protein-2; monocyte chemotactic protein 2; small-inducible cytokine A8", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (mmu:20307)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30084848;30779550;37567910", "class_list": "", "function": "Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity)., [UniProtKB]; Mesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Fas[lpr] mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0008201 heparin binding;GO:0016004 phospholipase activator activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007267 cell-cell signaling;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03311-1", "uniprot_id": "CHLE_MOUSE", "mass": 68462.0, "length": 603, "protein_name": "Cholinesterase", "gene_name": "Bche", "organism": "Mouse", "refseq_name": "cholinesterase isoform 1 precursor", "refseq_ac": "NP_033868", "gene_names_uniprotkb": "Bche", "gene_names_refseq": "Bche; C730038G20Rik", "protein_names_uniprotkb": "Cholinesterase; 3.1.1.8; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase", "protein_names_refseq": "acylcholine acylhydrolase; butyrylcholine esterase; choline esterase II; cholinesterase isoform 1 precursor; cholinesterase; pseudocholinesterase", "tax_id": 10090, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); stroke (Disease Ontology:DOID:0051061); trypanosomiasis (Disease Ontology:DOID:10113); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); familial hyperlipidemia (Disease Ontology:DOID:1168); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); epilepsy (Disease Ontology:DOID:1826); leptospirosis (Disease Ontology:DOID:2297); coronary artery disease (Disease Ontology:DOID:3393); coronary restenosis (Disease Ontology:DOID:4247); schizophrenia (Disease Ontology:DOID:5419); dystonia (Disease Ontology:DOID:543); inherited metabolic disorder (Disease Ontology:DOID:655); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); type 1 diabetes mellitus (Disease Ontology:DOID:9744); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:12038); (R-MMU-422085); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11929041;15318343;17194517;17212694;17467011;18056867;2016308;21750661;2400605;27091549;27300766;33300544;34428180", "class_list": "glycogene", "function": "A possible mechanism for partial compensation of tetanic fade in acetylcholinesterase knockout mice is hydrolysis of acetylcholine by normal levels of endogenous butyrylcholinesterase., [RefSeq, PubMed]; BChE strongly affects fat metabolism, has an important impact on fat accumulation and may be a promising tool for combating obesity., [RefSeq, PubMed]; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The absence of BChE leads to diminished fibrillar Abeta deposition in amygdala, hippocampal formation, thalamus and basal ganglia., [RefSeq, PubMed]; The effects of porphyrinogenic drugs on the brain cholinergic system (Ache, Bche, and Chrm1 levels in various regions of the brain) were examined to establish a mechanism for neurological syndrome displayed in acute porphyrias., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 22, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q543J3", "ec_number_list": "3.1.1.8", "go_molecular_function": "GO:0033265 choline binding;GO:0042802 identical protein binding;GO:0003990 acetylcholinesterase activity;GO:0004104 cholinesterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005641 nuclear envelope lumen;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0019695 choline metabolic process;GO:0043279 response to alkaloid;GO:0007584 response to nutrient;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58686-1", "uniprot_id": "BBLN_MOUSE", "mass": 9055.0, "length": 83, "protein_name": "Bublin coiled-coil protein", "gene_name": "Bbln", "organism": "Mouse", "refseq_name": "bublin coiled-coil protein", "refseq_ac": "NP_932118", "gene_names_uniprotkb": "Bbln; 1110008P14Rik", "gene_names_refseq": "1110008P14Rik; Bbln", "protein_names_uniprotkb": "Bublin coiled-coil protein; UPF0184 protein C9orf16 homolog", "protein_names_refseq": "UPF0184 protein C9orf16 homolog; bublin coiled-coil protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73737)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;33857431", "class_list": "", "function": "Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0030054 cell junction;GO:0005882 intermediate filament;GO:0120219 subapical part of cell;GO:0070161 anchoring junction", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045110 intermediate filament bundle assembly;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58686-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q149M0-1", "uniprot_id": "CL12B_MOUSE", "mass": 31186.0, "length": 275, "protein_name": "C-type lectin domain family 12 member B", "gene_name": "Clec12b", "organism": "Mouse", "refseq_name": "C-type lectin domain family 12 member B", "refseq_ac": "NP_001191152", "gene_names_uniprotkb": "Clec12b", "gene_names_refseq": "4933425B16Rik; Clec12b", "protein_names_uniprotkb": "C-type lectin domain family 12 member B", "protein_names_refseq": "C-type lectin domain family 12 member B; macrophage antigen h", "tax_id": 10090, "disease": "", "pathway": " (mmu:71183)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34020140;37294293", "class_list": "glycogene", "function": "CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components., [RefSeq, PubMed]; Inhibitory receptor postulated to negatively regulate immune and non-immune functions (By similarity). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (By similarity). Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (By similarity). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (By similarity). May protect target cells against natural killer cell-mediated lysis (By similarity). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (By similarity)., [UniProtKB, UniProtKB]; Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells. Erratum:[Biochem Biophys Res Commun. 2021 Sep 3;568:193-194. doi: 10.1016/j.bbrc.2021.07.009. PMID: 34246465], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9D403", "ec_number_list": "", "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0002769 natural killer cell inhibitory signaling pathway;GO:2000272 negative regulation of signaling receptor activity;GO:0097325 melanocyte proliferation;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:1904893 negative regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q149M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61400-1", "uniprot_id": "CEAMA_MOUSE", "mass": 29474.0, "length": 265, "protein_name": "Cell adhesion molecule CEACAM10", "gene_name": "Ceacam10", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM10 isoform 1 precursor", "refseq_ac": "NP_031701", "gene_names_uniprotkb": "Ceacam10; Cea10", "gene_names_refseq": "Bgp3; Cea10; Ceacam10", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM10; CEA cell adhesion molecule 10; CEA-related cell adhesion molecule 10; Carcinoembryonic antigen 10; Carcinoembryonic antigen-related cell adhesion molecule 10", "protein_names_refseq": "CEA-related cell adhesion molecule 10; carcinoembryonic antigen 10; carcinoembryonic antigen-related cell adhesion molecule 10; cell adhesion molecule CEACAM10 isoform 1 precursor; cell adhesion molecule CEACAM10", "tax_id": 10090, "disease": "", "pathway": " (mmu:26366)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12482980;15901639;21750661;7744068", "class_list": "", "function": "May interact with other CEACAM proteins on the sperm surface., [UniProtKB, PubMed]; Taken together, both Ceacam10 and Ceacam9, alone or in combination, are not essential for either murine placental and embryonic development or for adult life., [RefSeq, PubMed]; The purification and physiological role of CEACAM10 in male mice is reported. [CEACAM], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q99LD6;Q9D329", "ec_number_list": "", "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007165 signal transduction;GO:0006909 phagocytosis;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51682-1", "uniprot_id": "CCR5_MOUSE", "mass": 40785.0, "length": 354, "protein_name": "C-C chemokine receptor type 5", "gene_name": "Ccr5", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 5", "refseq_ac": "NP_034047", "gene_names_uniprotkb": "Ccr5; Cmkbr5", "gene_names_refseq": "AM4-7; CD195; Ccr5; Cmkbr5", "protein_names_uniprotkb": "C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; MIP-1 alpha receptor", "protein_names_refseq": "C-C CKR-5; C-C chemokine receptor type 5; CC-CKR-5; MIP-1 alpha receptor; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5", "tax_id": 10090, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599); type 1 diabetes mellitus 22 (Disease Ontology:DOID:0110759); dry eye syndrome (Disease Ontology:DOID:10140); berylliosis (Disease Ontology:DOID:10322); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sarcoidosis (Disease Ontology:DOID:11335); optic neuritis (Disease Ontology:DOID:1210); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); posterior uveitis (Disease Ontology:DOID:12574); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); anterior uveitis (Disease Ontology:DOID:1407); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); hepatitis C (Disease Ontology:DOID:1883); fallopian tube disease (Disease Ontology:DOID:1962); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); West Nile fever (Disease Ontology:DOID:2366); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); allergic contact dermatitis (Disease Ontology:DOID:3042); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); plague (Disease Ontology:DOID:3482); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); syphilis (Disease Ontology:DOID:4166); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893); leishmaniasis (Disease Ontology:DOID:9065); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12774); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;38709823;8631787;8662890;9261347;9343222", "class_list": "", "function": "CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 53, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35313;O35891;P97308;P97405;Q3ZAZ8;Q61867", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0019901 protein kinase binding;GO:0019957 C-C chemokine binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51682-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KL13-1", "uniprot_id": "DRIP1_MOUSE", "mass": 36304.0, "length": 310, "protein_name": "Dopamine receptor-interacting protein 1", "gene_name": "Dorip1; Gm527", "organism": "Mouse", "refseq_name": "dopamine receptor-interacting-protein 1", "refseq_ac": "NP_001020776", "gene_names_uniprotkb": "Dorip1; Gm527; Gm527", "gene_names_refseq": "Dorip1; Gm527", "protein_names_uniprotkb": "Dopamine receptor-interacting protein 1", "protein_names_refseq": "dopamine receptor-interacting-protein 1; uncharacterized protein C14orf28 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:217648)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37248637", "class_list": "", "function": "Could be a regulator of the dopamine receptor signaling pathway., [UniProtKB, PubMed]; Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KL13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03147-1", "uniprot_id": "CDK7_MOUSE", "mass": 38968.0, "length": 346, "protein_name": "Cyclin-dependent kinase 7", "gene_name": "Cdk7", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 7", "refseq_ac": "NP_034004", "gene_names_uniprotkb": "Cdk7; Cak; Cdkn7; Crk4; Mo15; Mpk-7", "gene_names_refseq": "C230069N13; CAK; Cdk7; Cdkn7; Crk4; P39 Mo15", "protein_names_uniprotkb": "Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 kDa protein kinase; CDK-activating kinase; CR4 protein kinase; CRK4; Cell division protein kinase 7; P39 Mo15; Protein-tyrosine kinase MPK-7; TFIIH basal transcription factor complex kinase subunit", "protein_names_refseq": "39 kDa protein kinase; CDK-activating kinase; CR4 protein kinase; CRK4 PK (CDC2-related-kinase-4 protein kinase); TFIIH basal transcription factor complex kinase subunit; cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7; protein-tyrosine kinase MPK-7", "tax_id": 10090, "disease": "primary congenital glaucoma (Disease Ontology:DOID:0050593); brachydactyly type A2 (Disease Ontology:DOID:0110965); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); breast cancer (Disease Ontology:DOID:1612); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:12572); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-69200); (R-MMU-69202); (R-MMU-69231); (R-MMU-69273); (R-MMU-69656); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-8939236)", "pathway_count": 26, "publication_count": 9, "publication_id_list": "1281307;1459009;21750661;34428180;36877894;7553872;7935441;7959010;8444355", "class_list": "", "function": "CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma., [RefSeq, PubMed]; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (By similarity). As a cyclin-dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and the CDK-activating kinase assembly factor MAT1 (By similarity). Catalytic subunit of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (By similarity). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (By similarity). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (By similarity). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99KK3", "ec_number_list": "2.7.11.1;2.7.11.25;3.6.4.-;5.6.2.3;2.7.11.24;2.7.12.2;2.7.7.6;2.7.12.1;2.7.11.22;3.4.-.-;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.4.2.-;2.4.2.30;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;3.1.13.-;2.7.7.48;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;3.1.-.-;6.5.1.1;2.7.1.153;2.7.1.137;5.6.2.4;2.7.7.7;2.7.1.40;2.7.11.21;1.14.11.-;2.3.2.27;2.3.2.32;2.3.1.48;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;3.4.19.12;3.1.3.16;4.1.1.32;3.6.4.13;2.7.11.38;3.6.1.-;3.6.-.-;3.1.27.-;2.1.1.56;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;5.2.1.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6T1-1", "uniprot_id": "CDR2L_MOUSE", "mass": 53213.0, "length": 465, "protein_name": "Cerebellar degeneration-related protein 2-like", "gene_name": "Cdr2l", "organism": "Mouse", "refseq_name": "cerebellar degeneration-related protein 2-like", "refseq_ac": "NP_001074398", "gene_names_uniprotkb": "Cdr2l; Gm21", "gene_names_refseq": "Cdr2l; D030068L24Rik; Gm21", "protein_names_uniprotkb": "Cerebellar degeneration-related protein 2-like", "protein_names_refseq": "cerebellar degeneration-related protein 2-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:237988)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A6T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGF9-1", "uniprot_id": "CCD9B_MOUSE", "mass": 58688.0, "length": 545, "protein_name": "Coiled-coil domain-containing protein 9B", "gene_name": "Ccdc9b", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 9B", "refseq_ac": "NP_001001982", "gene_names_uniprotkb": "Ccdc9b", "gene_names_refseq": "A430105I19Rik; Ccdc9b; Gm353", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 9B", "protein_names_refseq": "coiled-coil domain-containing protein 9B; uncharacterized protein C15orf52 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:214239)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV54;Q6DI90", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KGF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BN45-1", "uniprot_id": "PIRC1_MOUSE", "mass": 18836.0, "length": 167, "protein_name": "Piercer of microtubule wall 1 protein", "gene_name": "Pierce1", "organism": "Mouse", "refseq_name": "piercer of microtubule wall 1 protein", "refseq_ac": "NP_081316", "gene_names_uniprotkb": "Pierce1", "gene_names_refseq": "1700007K13Rik; Pierce1; Rbest47", "protein_names_uniprotkb": "Piercer of microtubule wall 1 protein; Pierce1; p53-induced expression in RB-null cells protein 1", "protein_names_refseq": "UPF0691 protein C9orf116 homolog; p53-induced expression in RB-null cells protein 1; pierce 1; piercer of microtubule wall 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69327)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18182857;21159655;21750661;27305836;34715025;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:34715025, PubMed:37295417, PubMed:37865089, PubMed:37989994). Functions at the initial step of left-right asymmetry specification of the visceral organs (PubMed:27305836)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RbEST47 was considerably down-regulated in immortalized cells, and showed cell cycle-dependent expression, suggesting important roles in S and/or G2[RbEST47], [RefSeq, PubMed]; This is the first report implicating a role for PIERCE1 in the symmetry-breaking step of left-right asymmetry specification. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006974 DNA damage response;GO:0007368 determination of left/right symmetry;GO:0010468 regulation of gene expression;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5BN45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RW38-1", "uniprot_id": "CFA58_MOUSE", "mass": 103524.0, "length": 873, "protein_name": "Cilia- and flagella-associated protein 58", "gene_name": "Cfap58", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 58", "refseq_ac": "NP_001156739", "gene_names_uniprotkb": "Cfap58", "gene_names_refseq": "Ccdc147; Cfap58; Gm969", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 58", "protein_names_refseq": "cilia- and flagella-associated protein 58; coiled-coil domain containing 147", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); spermatogenic failure 49 (Disease Ontology:DOID:0112271)", "pathway": " (mmu:381229)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31904090;32791035;38602507", "class_list": "", "function": "Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice., [RefSeq, PubMed]; CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice., [RefSeq, PubMed]; Has an essential role in the assembly and organization of the sperm flagellar axoneme (PubMed:32791035). Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (PubMed:31904090)., [UniProtKB, PubMed, PubMed]; The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007288 sperm axoneme assembly;GO:0120229 protein localization to motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B2RW38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04186-1", "uniprot_id": "CFAB_MOUSE", "mass": 85004.0, "length": 761, "protein_name": "Complement factor B", "gene_name": "Cfb", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cfb; Bf; H2-Bf", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement factor B; 3.4.21.47; C3/C5 convertase", "protein_names_refseq": "", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 14 (Disease Ontology:DOID:0110026); lepromatous leprosy (Disease Ontology:DOID:10887); sickle cell anemia (Disease Ontology:DOID:10923); membranous glomerulonephritis (Disease Ontology:DOID:10976); pyelonephritis (Disease Ontology:DOID:11400); factor VIII deficiency (Disease Ontology:DOID:12134); beta thalassemia (Disease Ontology:DOID:12241); paracoccidioidomycosis (Disease Ontology:DOID:12662); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); breast cancer (Disease Ontology:DOID:1612); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); IgA glomerulonephritis (Disease Ontology:DOID:2986); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); conjunctivitis (Disease Ontology:DOID:6195); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14962); (R-MMU-173736); (R-MMU-174577); (R-MMU-977606)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "14656967;16944957;17330941;21750661;2229060;25428506;26495903;26740625;28011936;32152506;36288343;37507081;39627609;6689022", "class_list": "", "function": "Involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the complement C3 and C5 convertase complexes of the alternative complement pathway. Following cleavage and activation by factor D (CFD), forms the C3 convertase together with complement C3b. As part of the C3 convertase, cleaves and activates C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. When an additional complement C3b molecule binds to the C3 convertase, forms the C5 convertase, which cleaves and activates C5 into C5a anaphylatoxin and C5b component of the membrane attack complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 27, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.46;3.4.21.47", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0098548 cytoplasmic side of Golgi membrane;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0009617 response to bacterium;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P04186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQ47-1", "uniprot_id": "CNPY4_MOUSE", "mass": 28094.0, "length": 245, "protein_name": "Protein canopy homolog 4", "gene_name": "Cnpy4", "organism": "Mouse", "refseq_name": "protein canopy homolog 4 isoform 2 precursor", "refseq_ac": "NP_848727", "gene_names_uniprotkb": "Cnpy4; Prat4b", "gene_names_refseq": "2610019P18Rik; Cnpy4", "protein_names_uniprotkb": "Protein canopy homolog 4; Protein associated with Tlr4", "protein_names_refseq": "canopy 4 homolog; protein associated with Tlr4; protein canopy homolog 4 isoform 2 precursor; protein canopy homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66455)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16338228;21750661;31219806", "class_list": "", "function": "Plays a role in the regulation of the cell surface expression of TLR4., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT84;Q8BTB1;Q8CCG0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0061024 membrane organization;GO:0032880 regulation of protein localization;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0042733 embryonic digit morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BQ47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZK1-1", "uniprot_id": "CEP44_MOUSE", "mass": 43255.0, "length": 386, "protein_name": "Centrosomal protein of 44 kDa", "gene_name": "Cep44", "organism": "Mouse", "refseq_name": "centrosomal protein of 44 kDa", "refseq_ac": "NP_001009951", "gene_names_uniprotkb": "Cep44; BC088983; Kiaa1712", "gene_names_refseq": "4933440G23Rik; Cep44; mKIAA1712", "protein_names_uniprotkb": "Centrosomal protein of 44 kDa; Cep44", "protein_names_refseq": "centrosomal protein of 44 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:382010)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTV5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole;GO:0030496 midbody", "go_biological_process": "GO:0007098 centrosome cycle;GO:0010457 centriole-centriole cohesion;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35903-1", "uniprot_id": "CCL25_MOUSE", "mass": 16733.0, "length": 144, "protein_name": "C-C motif chemokine 25", "gene_name": "Ccl25", "organism": "Mouse", "refseq_name": "C-C motif chemokine 25 precursor", "refseq_ac": "NP_033164", "gene_names_uniprotkb": "Ccl25; Scya25; Teck", "gene_names_refseq": "A130072A22Rik; CKb15; Ccl25; Scya25; TECK", "protein_names_uniprotkb": "C-C motif chemokine 25; Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine", "protein_names_refseq": "C-C motif chemokine 25 precursor; C-C motif chemokine 25; chemokine (C-C motif) ligand 25; small inducible chemokine 25; small inducible cytokine A25; thymus-expressed chemokine", "tax_id": 10090, "disease": "", "pathway": " (mmu:20300); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10602049;11981810;16517733;21750661;33647585;36161509;39236454;9285413", "class_list": "", "function": "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. (CCX-CKR), [RefSeq, PubMed]; Piezo1 activation on microglial cells exacerbates demyelination in sepsis by influencing the CCL25/GRP78 pathway., [RefSeq, PubMed]; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4., [UniProtKB]; The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo., [RefSeq, PubMed]; ZIM3 activation of CCL25 expression in pulmonary metastatic nodules of osteosarcoma recruits M2 macrophages to promote metastatic growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYY6", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0031735 CCR10 chemokine receptor binding;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BT18-1", "uniprot_id": "ARMD4_MOUSE", "mass": 83774.0, "length": 775, "protein_name": "Armadillo-like helical domain-containing protein 4", "gene_name": "Armh4", "organism": "Mouse", "refseq_name": "armadillo-like helical domain-containing protein 4 isoform 1 precursor", "refseq_ac": "NP_080418", "gene_names_uniprotkb": "Armh4; 3632451O06Rik; Ut2", "gene_names_refseq": "3632451O06Rik; Armh4", "protein_names_uniprotkb": "Armadillo-like helical domain-containing protein 4; Upstream of mTORC2 protein", "protein_names_refseq": "armadillo-like helical domain-containing protein 4 isoform 1 precursor; armadillo-like helical domain-containing protein 4; uncharacterized protein C14orf37 homolog; upstream of mTORC2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67419)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25418727;26927669", "class_list": "", "function": "May modulate immune response and may play a role in inflammation. Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705' (PubMed:26927669). May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (PubMed:25418727)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFQ7;Q8R1Q5;Q9D6C5", "ec_number_list": "", "go_molecular_function": "GO:1904841 TORC2 complex binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0010226 response to lithium ion;GO:0050727 regulation of inflammatory response;GO:1903939 regulation of TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BT18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76EC5-1", "uniprot_id": "CHST9_MOUSE", "mass": 48004.0, "length": 413, "protein_name": "Carbohydrate sulfotransferase 9", "gene_name": "Chst9", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 9 isoform 1", "refseq_ac": "NP_951010", "gene_names_uniprotkb": "Chst9", "gene_names_refseq": "5430438D01Rik; Chst9; GalNAc4ST-2; galNAc-4-ST2", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 9; 2.8.2.-; GalNAc-4-O-sulfotransferase 2; GalNAc-4-ST2; GalNAc4ST-2; N-acetylgalactosamine-4-O-sulfotransferase 2", "protein_names_refseq": "N-acetylgalactosamine-4-O-sulfotransferase 2; carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9; carbohydrate sulfotransferase 9 isoform 1; galNAc-4-O-sulfotransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71367); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12944377;21750661", "class_list": "glycan-modifying enzyme;glycogene;glycosyltransferase", "function": "Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans (PubMed:12944377). Transfers sulfate to the C-4 hydroxyl of terminal beta-1,4-linked GalNAc in the sequence GalNAc-beta-1,4GlcNAcbeta-R found on N-linked oligosaccharides and to the nonterminal beta-1,4-linked GalNAc in chondroitin and dermatan. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.5", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0006790 sulfur compound metabolic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 139, "hit_score": 0.3, "record_id": "Q76EC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35744-1", "uniprot_id": "CHIL3_MOUSE", "mass": 44458.0, "length": 398, "protein_name": "Chitinase-like protein 3", "gene_name": "Chil3", "organism": "Mouse", "refseq_name": "chitinase-like protein 3 precursor", "refseq_ac": "NP_034022", "gene_names_uniprotkb": "Chil3; Chi3l3; Ym1", "gene_names_refseq": "Chi3l3; Chil3; ECF-L; Ym1", "protein_names_uniprotkb": "Chitinase-like protein 3; 3.2.1.52; Beta-N-acetylhexosaminidase Ym1; Chitinase-3-like protein 3; ECF-L; Eosinophil chemotactic cytokine; Secreted protein Ym1", "protein_names_refseq": "beta-N-acetylhexosaminidase Ym1; chitinase-like protein 3 precursor; chitinase-like protein 3; eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; secreted protein Ym1", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); neuromyelitis optica (Disease Ontology:DOID:8869)", "pathway": " (mmu:12655)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10625674;11141507;11278670;11297523;11733538;12101265;12215441;15148607;15522777;21750661;26495903;26740625;34428180;36244794;36883357;38194250;9828134", "class_list": "glycogene;glycosylhydrolase", "function": "Hyalinosis is due to the overexpression of ym1 (now chi3I3) in cells and tissues, often associated with disease in that tissue., [RefSeq, PubMed]; Irreversible evolutionary loss of chitin-degrading ability in the chitinase-like protein Ym1 under positive selection in rodents., [RefSeq, PubMed]; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy., [UniProtKB, PubMed, PubMed, PubMed]; Pathological examination of Ym1, a chitinase family protein, in Mesocestoides corti-infected mice., [RefSeq, PubMed]; The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]., [RefSeq]; Ym1 protein crystals promote type 2 immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 111, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70201;Q3U462;Q3UV87;Q61201", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding;GO:0030246 carbohydrate binding;GO:0004568 chitinase activity;GO:0008061 chitin binding;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006954 inflammatory response;GO:0032722 positive regulation of chemokine production;GO:0010269 response to selenium ion;GO:0000272 polysaccharide catabolic process;GO:0002532 production of molecular mediator involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07643-1", "uniprot_id": "CO9A2_MOUSE", "mass": 65321.0, "length": 688, "protein_name": "Collagen alpha-2(IX) chain", "gene_name": "Col9a2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Col9a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-2(IX) chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "multiple epiphyseal dysplasia 2 (Disease Ontology:DOID:0070298); Stickler syndrome (Disease Ontology:DOID:0080046); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:12840); (R-MMU-1650814); (R-MMU-186797); (R-MMU-2022090); (R-MMU-216083); (R-MMU-3000178); (R-MMU-419037); (R-MMU-8948216)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "1543751;21750661;8106484", "class_list": "glycogene", "function": "Structural component of hyaline cartilage and vitreous of the eye., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07643-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05208-1", "uniprot_id": "CEL2A_MOUSE", "mass": 28914.0, "length": 271, "protein_name": "Chymotrypsin-like elastase family member 2A", "gene_name": "Cela2a", "organism": "Mouse", "refseq_name": "chymotrypsin-like elastase family member 2A preproprotein", "refseq_ac": "NP_031945", "gene_names_uniprotkb": "Cela2a; Ela-2; Ela2a; Ela2", "gene_names_refseq": "Cela2a; Ela-2; Ela2a; Ela2", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 2A; 3.4.21.71; Elastase-2A; Elastase-2", "protein_names_refseq": "chymotrypsin-like elastase family member 2A preproprotein; elastase 2A", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome 4 (Disease Ontology:DOID:0080945)", "pathway": " (mmu:13706); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20179351;31358993;3641189", "class_list": "", "function": "ELA2 as a major new epidermal protease involved in essential pathways for skin barrier function., [RefSeq, PubMed]; Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity., [UniProtKB, PubMed]; This gene encodes a serine protease enzyme that hydrolyzes elastin. This gene is highly expressed in the pancreatic acinar cells where the encoded preproprotein undergoes processing including signal peptide cleavage to generate an inactive zymogen. The removal of N-terminal activation peptide from the zymogen by trypsin generates active elastase enzyme. This gene is also expressed in the mouse epidermis where it participates in pro-filaggrin processing. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.71", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0036457 keratohyalin granule", "go_biological_process": "GO:0006508 proteolysis;GO:0050796 regulation of insulin secretion;GO:0032868 response to insulin;GO:1901143 insulin catabolic process;GO:0090330 regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21180-1", "uniprot_id": "CO2_MOUSE", "mass": 84741.0, "length": 760, "protein_name": "Complement C2", "gene_name": "C2", "organism": "Mouse", "refseq_name": "complement C2 preproprotein", "refseq_ac": "NP_038512", "gene_names_uniprotkb": "C2", "gene_names_refseq": "C2", "protein_names_uniprotkb": "Complement C2; C3/C5 convertase", "protein_names_refseq": "MHC complement component C2; classical-complement pathway C3/C5 convertase; complement C2 preproprotein; complement component 2 (within H-2S); complement factor C2", "tax_id": 10090, "disease": "complement component 2 deficiency (Disease Ontology:DOID:0060295); polycystic kidney disease (Disease Ontology:DOID:0080322); age related macular degeneration 14 (Disease Ontology:DOID:0110026); Alzheimer's disease (Disease Ontology:DOID:10652); macular degeneration (Disease Ontology:DOID:4448); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12263); (R-MMU-166663); (R-MMU-174577); (R-MMU-977606)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;14656967;20065024;21750661;2229060;22689574;25428506;26740625;30084848;34428180", "class_list": "", "function": "Bacterial titers of both Streptococcus pneumoniae serotype 6A and 14 in the middle ear lavage fluid samples from Bf/C2(-/)(-), Bf(-)(/)(-), and C1qa(-/)(-) mice were significantly higher than in samples from wild-type mice., [RefSeq, PubMed]; Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data indicate that activation of C5 in experimental cerebral malaria likely occurs via coagulation enzymes of the extrinsic protease pathway., [RefSeq, PubMed]; Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O70350", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005601 classical-complement-pathway C3/C5 convertase complex;GO:0106139 symbiont cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0009617 response to bacterium;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P21180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25318-1", "uniprot_id": "CO8A2_MOUSE", "mass": 66943.0, "length": 699, "protein_name": "Collagen alpha-2(VIII) chain", "gene_name": "Col8a2", "organism": "Mouse", "refseq_name": "collagen alpha-2(VIII) chain precursor", "refseq_ac": "NP_955767", "gene_names_uniprotkb": "Col8a2", "gene_names_refseq": "Col8a2", "protein_names_uniprotkb": "Collagen alpha-2(VIII) chain; Endothelial collagen", "protein_names_refseq": "collagen alpha-2(VIII) chain precursor; collagen alpha-2(VIII) chain; endothelial collagen; procollagen, type VIII, alpha 2", "tax_id": 10090, "disease": "posterior polymorphous corneal dystrophy 2 (Disease Ontology:DOID:0110856); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555)", "pathway": " (mmu:329941); (R-MMU-1442490); (R-MMU-1650814); (R-MMU-2022090); (R-MMU-216083); (R-MMU-8948216)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "19401424;2019595;21750661;35820727;37453647", "class_list": "", "function": "Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KFY2;Q68ED0;Q6KAQ4;Q6P1C4", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0071953 elastic fiber", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0048593 camera-type eye morphogenesis;GO:0050673 epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30276-1", "uniprot_id": "CCNB2_MOUSE", "mass": 45383.0, "length": 398, "protein_name": "G2/mitotic-specific cyclin-B2", "gene_name": "Ccnb2", "organism": "Mouse", "refseq_name": "G2/mitotic-specific cyclin-B2", "refseq_ac": "NP_031656", "gene_names_uniprotkb": "Ccnb2; Cycb2", "gene_names_refseq": "Ccnb2; CycB2", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B2", "protein_names_refseq": "G2/mitotic-specific cyclin-B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:12442); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-2980767); (R-MMU-2995383); (R-MMU-3301854); (R-MMU-69273); (R-MMU-69478); (R-MMU-8852276)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "21183079;28315936;34428180;36210013;8375336", "class_list": "", "function": "Essential for the control of the cell cycle at the G2/M (mitosis) transition., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922E9", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0040008 regulation of growth;GO:0051301 cell division;GO:0048538 thymus development;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05AH6-1", "uniprot_id": "SPNDC_MOUSE", "mass": 41245.0, "length": 381, "protein_name": "Spindlin interactor and repressor of chromatin-binding protein", "gene_name": "Spindoc", "organism": "Mouse", "refseq_name": "spindlin interactor and repressor of chromatin-binding protein isoform 1", "refseq_ac": "NP_001028311", "gene_names_uniprotkb": "Spindoc", "gene_names_refseq": "1700105P06Rik; SPIN-DOC; Spindoc", "protein_names_uniprotkb": "Spindlin interactor and repressor of chromatin-binding protein; SPIN-DOC; SPIN1-docking protein", "protein_names_refseq": "SPIN1-docking protein; spindlin interactor and repressor of chromatin-binding protein isoform 1; spindlin interactor and repressor of chromatin-binding protein; uncharacterized protein C11orf84 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68229)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;29061846;34526015;34737271", "class_list": "", "function": "Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (By similarity). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271)., [UniProtKB, UniProtKB, PubMed]; SPINDOC binds PARP1 to facilitate PARylation. Publication Status: Online-Only, [RefSeq, PubMed]; The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI49;Q3TQH2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0010835 regulation of protein ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05AH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07424-1", "uniprot_id": "CDX4_MOUSE", "mass": 30465.0, "length": 282, "protein_name": "Homeobox protein CDX-4", "gene_name": "Cdx4", "organism": "Mouse", "refseq_name": "homeobox protein CDX-4", "refseq_ac": "NP_031700", "gene_names_uniprotkb": "Cdx4; Cdx-4", "gene_names_refseq": "Cdx-3; Cdx-4; Cdx3; Cdx4", "protein_names_uniprotkb": "Homeobox protein CDX-4; Caudal-type homeobox protein 4", "protein_names_refseq": "caudal type homeo box 4; caudal-type homeobox protein 4; homeobox protein CDX-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:12592)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20485683;7902125", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07424-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VG62-2", "uniprot_id": "RBIS_MOUSE", "mass": 11163.0, "length": 97, "protein_name": "Ribosomal biogenesis factor", "gene_name": "Rbis", "organism": "Mouse", "refseq_name": "ribosomal biogenesis factor isoform 2", "refseq_ac": "NP_001093144", "gene_names_uniprotkb": "Rbis", "gene_names_refseq": "1810022K09Rik; Rbis", "protein_names_uniprotkb": "Ribosomal biogenesis factor", "protein_names_refseq": "ribosomal biogenesis factor isoform 2; uncharacterized protein C8orf59 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69126)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UW58", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VG62-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14B71-1", "uniprot_id": "CDCA2_MOUSE", "mass": 106366.0, "length": 982, "protein_name": "Cell division cycle-associated protein 2", "gene_name": "Cdca2", "organism": "Mouse", "refseq_name": "cell division cycle-associated protein 2", "refseq_ac": "NP_001103632", "gene_names_uniprotkb": "Cdca2", "gene_names_refseq": "2610311M19Rik; Cdca2", "protein_names_uniprotkb": "Cell division cycle-associated protein 2", "protein_names_refseq": "cell division cycle-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108912)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;25428506;28528544;34887587;35820727", "class_list": "", "function": "Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phosphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSQ1;Q8CD75", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000793 condensed chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007088 regulation of mitotic nuclear division;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q14B71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3S3-1", "uniprot_id": "CENPL_MOUSE", "mass": 37725.0, "length": 329, "protein_name": "Centromere protein L", "gene_name": "Cenpl", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cenpl", "gene_names_refseq": "", "protein_names_uniprotkb": "Centromere protein L; CENP-L", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKF0;Q9CSU9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus", "go_biological_process": "GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U3S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U4G0-1", "uniprot_id": "CDIN1_MOUSE", "mass": 32113.0, "length": 281, "protein_name": "CDAN1-interacting nuclease 1", "gene_name": "Cdin1", "organism": "Mouse", "refseq_name": "CDAN1-interacting nuclease 1 isoform 1", "refseq_ac": "NP_001139370", "gene_names_uniprotkb": "Cdin1; BC052040", "gene_names_refseq": "Cdin1", "protein_names_uniprotkb": "CDAN1-interacting nuclease 1", "protein_names_refseq": "CDAN1-interacting nuclease 1 isoform 1; uncharacterized protein C15orf41 homolog", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia type Ib (Disease Ontology:DOID:0111397)", "pathway": " (mmu:399568)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Plays a role in erythroid cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WT3;Q8C1X6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U4G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJC8-1", "uniprot_id": "CE034_MOUSE", "mass": 72263.0, "length": 639, "protein_name": "Uncharacterized protein C5orf34 homolog", "gene_name": "4833420G17Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C5orf34 homolog", "refseq_ac": "NP_001107022", "gene_names_uniprotkb": "4833420G17Rik", "gene_names_refseq": "2210017J06Rik; 4833420G17Rik; 5730533D17Rik", "protein_names_uniprotkb": "Uncharacterized protein C5orf34 homolog", "protein_names_refseq": "uncharacterized protein C5orf34 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67392)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18299400;21750661;21952136;25428506;30779550;34203471;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUB6;Q3UF19;Q78HE1;Q8K3D5;Q9CUS5;Q9D822", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UJC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UY96-1", "uniprot_id": "CFA74_MOUSE", "mass": 178928.0, "length": 1578, "protein_name": "Cilia- and flagella-associated protein 74", "gene_name": "Cfap74", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 74 isoform 1", "refseq_ac": "NP_808342", "gene_names_uniprotkb": "Cfap74", "gene_names_refseq": "2010015L04Rik; A530045M11; Cfap74", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 74", "protein_names_refseq": "cilia- and flagella-associated protein 74 isoform 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:544678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34887587", "class_list": "", "function": "As part of the central apparatus of the cilium axoneme may play a role in cilium movement. May play an important role in sperm architecture and function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AD78;A4QMY6;F6VQ96;Q14DK1;Q8BI90", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UY96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0B4-1", "uniprot_id": "CFA65_MOUSE", "mass": 209134.0, "length": 1847, "protein_name": "Cilia- and flagella-associated protein 65", "gene_name": "Cfap65", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 65", "refseq_ac": "NP_001034584", "gene_names_uniprotkb": "Cfap65; Ccdc108", "gene_names_refseq": "A230051F10; B230363K08Rik; Ccdc108; Cfap65", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 65; Coiled-coil domain-containing protein 108", "protein_names_refseq": "cilia- and flagella-associated protein 65; coiled-coil domain containing 108; coiled-coil domain-containing protein 108", "tax_id": 10090, "disease": "spermatogenic failure 40 (Disease Ontology:DOID:0111918)", "pathway": " (mmu:241116)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;31413122;31501240;31571197;33472045;34231842;39853433", "class_list": "", "function": "Biallelic mutations in CFAP65 cause male infertility with multiple morphological abnormalities of the sperm flagella in humans and mice., [RefSeq, PubMed]; CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis., [RefSeq, PubMed]; Ccdc108 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Plays a role in flagellar formation and sperm motility (PubMed:31501240). Essential for acrosome formation, manchette organization, spermatid head morphogenesis and mitochondrial sheath assembly within the sperm flagellum during spermiogenesis (PubMed:34231842). Also required for proper assembly and stabilization of the C2a projection, a structural subunit of the central pair apparatus within the axoneme of motile cilia and flagella (PubMed:39853433)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:0003341 cilium movement;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V0B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497N7-1", "uniprot_id": "TEX56_MOUSE", "mass": 26076.0, "length": 227, "protein_name": "Testis expressed protein 56", "gene_name": "Tex56", "organism": "Mouse", "refseq_name": "testis expressed protein 56", "refseq_ac": "NP_080026", "gene_names_uniprotkb": "Tex56", "gene_names_refseq": "4933417A18Rik; Tex56", "protein_names_uniprotkb": "Testis expressed protein 56", "protein_names_refseq": "testis expressed protein 56; uncharacterized protein C6orf201 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66761)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27357688", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D433;Q9D460", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q497N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q569L8-1", "uniprot_id": "CPAP_MOUSE", "mass": 153079.0, "length": 1344, "protein_name": "Centrosomal P4.1-associated protein", "gene_name": "Cpap", "organism": "Mouse", "refseq_name": "centrosomal P4.1-associated protein isoform 1", "refseq_ac": "NP_001014996", "gene_names_uniprotkb": "Cpap; Cenpj", "gene_names_refseq": "4932437H03Rik; Cenpj; Cpap; Gm81; LAP; LIP1; Sas4", "protein_names_uniprotkb": "Centrosomal P4.1-associated protein; CENP-J; Centromere protein J; Centrosome assembly and centriole elongation protein", "protein_names_refseq": "CENP-J; centromere protein J; centrosomal P4.1-associated protein isoform 1; centrosomal P4.1-associated protein", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Seckel syndrome 4 (Disease Ontology:DOID:0070010); primary autosomal recessive microcephaly 6 (Disease Ontology:DOID:0070290); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:219103); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6804115); (R-MMU-8854518)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "21750661;23166506;31219806;34940974;39627609", "class_list": "", "function": "Microcephaly gene Cenpj regulates axonal growth in cortical neurons through microtubule destabilization., [RefSeq, PubMed]; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity)., [UniProtKB, UniProtKB]; We have developed a mouse (Cenpj(tm/tm)) that recapitulates many of the clinical features of Seckel syndrome, thus providing clear confirmation that specific mutations of CENPJ can cause Seckel syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLP3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0001669 acrosomal vesicle;GO:0005814 centriole", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0046785 microtubule polymerization;GO:1905832 positive regulation of spindle assembly;GO:1904951 positive regulation of establishment of protein localization;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q569L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JV7-1", "uniprot_id": "CH058_MOUSE", "mass": 40582.0, "length": 365, "protein_name": "Uncharacterized protein C8orf58 homolog", "gene_name": "9930012K11Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C8orf58 homolog isoform 1", "refseq_ac": "NP_001004155", "gene_names_uniprotkb": "9930012K11Rik", "gene_names_refseq": "9930012K11Rik", "protein_names_uniprotkb": "Uncharacterized protein C8orf58 homolog", "protein_names_refseq": "uncharacterized protein C8orf58 homolog isoform 1; uncharacterized protein C8orf58 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:268759)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1T6;Q8K281", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66JV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A068-1", "uniprot_id": "CDC5L_MOUSE", "mass": 92190.0, "length": 802, "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5l", "organism": "Mouse", "refseq_name": "cell division cycle 5-like protein", "refseq_ac": "NP_690023", "gene_names_uniprotkb": "Cdc5l; Kiaa0432", "gene_names_refseq": "1200002I02Rik; Cdc5l; PCDC5RP", "protein_names_uniprotkb": "Cell division cycle 5-like protein; Cdc5-like protein", "protein_names_refseq": "cdc5-like protein; cell division cycle 5-like protein; cell division cycle 5-related protein", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteosarcoma (Disease Ontology:DOID:3347); esophagus adenocarcinoma (Disease Ontology:DOID:4914)", "pathway": " (mmu:71702); (R-MMU-72163)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10570151;25428506;30084848;30779550;31219806;34428180;34887587;39627609;40021952", "class_list": "", "function": "DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1J9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6A068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IRU7-1", "uniprot_id": "CEP78_MOUSE", "mass": 86890.0, "length": 790, "protein_name": "Centrosomal protein of 78 kDa", "gene_name": "Cep78", "organism": "Mouse", "refseq_name": "centrosomal protein of 78 kDa", "refseq_ac": "NP_932136", "gene_names_uniprotkb": "Cep78", "gene_names_refseq": "5730599I05Rik; Cep78; D030027P05", "protein_names_uniprotkb": "Centrosomal protein of 78 kDa; Cep78", "protein_names_refseq": "centrosomal protein of 78 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:208518); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "21750661;25428506;27588451;27588452;30084848;34428180;36206347;36756949", "class_list": "", "function": "Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual. Publication Status: Online-Only, [RefSeq, PubMed]; Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:36206347, PubMed:36756949). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (By similarity). Involved in cilium biogenesis and controls cilium length (PubMed:36206347, PubMed:36756949). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:36206347). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (By similarity). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (PubMed:36206347)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Loss-of-function mutations in CEP78 cause male infertility in humans and mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization;GO:0031397 negative regulation of protein ubiquitination;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IRU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1I3-1", "uniprot_id": "KICS2_MOUSE", "mass": 50256.0, "length": 445, "protein_name": "KICSTOR subunit 2", "gene_name": "Kics2", "organism": "Mouse", "refseq_name": "KICSTOR subunit 2 isoform 1", "refseq_ac": "NP_766610", "gene_names_uniprotkb": "Kics2; BC048403", "gene_names_refseq": "E030027L10; Kics2", "protein_names_uniprotkb": "KICSTOR subunit 2", "protein_names_refseq": "KICSTOR complex protein C12orf66 homolog; KICSTOR subunit 2 isoform 1; UPF0536 protein C12orf66 homolog", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 83 (Disease Ontology:DOID:0061114)", "pathway": " (mmu:270802); (R-MMU-9639288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE08;Q3TRB8;Q8C334", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0140007 KICSTOR complex;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0045171 intercellular bridge", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P1I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE87-1", "uniprot_id": "CF206_MOUSE", "mass": 70946.0, "length": 622, "protein_name": "Cilia- and flagella-associated protein 206", "gene_name": "Cfap206", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 206 isoform 1", "refseq_ac": "NP_001333991", "gene_names_uniprotkb": "Cfap206; 1700003M02Rik", "gene_names_refseq": "1700003M02Rik; Cfap206", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 206", "protein_names_refseq": "UPF0704 protein C6orf165 homolog; cilia- and flagella-associated protein 206 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69329)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;21750661;31219806;32376681;34255152;35820727;36210013", "class_list": "", "function": "1700003M02Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons and testis, and is predicted to be important to cilia., [RefSeq, PubMed]; Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse., [RefSeq, PubMed]; Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AT45;A2AT46;A2AT47;Q9DAP6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization;GO:0003341 cilium movement;GO:0003356 regulation of cilium beat frequency", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PE87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X32-1", "uniprot_id": "CE024_MOUSE", "mass": 20139.0, "length": 188, "protein_name": "UPF0461 protein C5orf24 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0461 protein C5orf24 homolog", "refseq_ac": "NP_851795", "gene_names_uniprotkb": "", "gene_names_refseq": "B230219D22Rik; D530037I19Rik", "protein_names_uniprotkb": "UPF0461 protein C5orf24 homolog", "protein_names_refseq": "UPF0461 protein C5orf24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78521)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2G2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80X32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XD1-1", "uniprot_id": "CHIO_MOUSE", "mass": 38218.0, "length": 332, "protein_name": "Beta-chimaerin", "gene_name": "Chn2", "organism": "Mouse", "refseq_name": "beta-chimaerin isoform 3", "refseq_ac": "NP_001298062", "gene_names_uniprotkb": "Chn2; Arhgap3; Bch", "gene_names_refseq": "1700026N20Rik; 4930557O16Rik; ARHGAP3; Bch; Chn2", "protein_names_uniprotkb": "Beta-chimaerin; Beta-chimerin; Rho GTPase-activating protein 3", "protein_names_refseq": "Rho GTPase-activating protein 3; beta-chimaerin isoform 3; beta-chimaerin; chimerin (chimaerin) 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69993); (R-MMU-9013149)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20335173;21750661;27058424;31209021", "class_list": "", "function": "Essential for neural stem cell homeostasis in mouse adult neurogenesis, [RefSeq, PubMed]; GTPase-activating protein for p21-rac., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression., [RefSeq, PubMed]; The Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9W2;Q9ER57", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80XD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YP0-1", "uniprot_id": "CDK3_MOUSE", "mass": 34075.0, "length": 304, "protein_name": "Cyclin-dependent kinase 3", "gene_name": "Cdk3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cdk3; Cdk3-ps; Cdkn3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 3; 2.7.11.22; Cell division protein kinase 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11172011;11733001;11955625", "class_list": "", "function": "Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLP6;Q9D6V6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0007165 signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045746 negative regulation of Notch signaling pathway;GO:0045023 G0 to G1 transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80YP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810P3-1", "uniprot_id": "CDKN3_MOUSE", "mass": 23793.0, "length": 211, "protein_name": "Cyclin-dependent kinase inhibitor 3", "gene_name": "Cdkn3", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase inhibitor 3 isoform 2", "refseq_ac": "NP_082498", "gene_names_uniprotkb": "Cdkn3; Kap", "gene_names_refseq": "2410006H10Rik; Cdkn3; KAP", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 3; 3.1.3.16; 3.1.3.48; CDK2-associated dual-specificity phosphatase; Kinase-associated phosphatase", "protein_names_refseq": "CDK2-associated dual-specificity phosphatase; cyclin-dependent kinase inhibitor 3 isoform 2; kinase-associated phosphatase", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:72391)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;29196103;31219806;31352814;34428180", "class_list": "", "function": "Knockdown of CDKN3 expression inhibited prostate cancer tumor growth in the nude mouse model., [RefSeq, PubMed]; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity)., [UniProtKB, UniProtKB]; NEAT1 may exert a protective effect on HUVECs by regulating the miR-181d-5p/CDKN3A axis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWS3", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q810P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGD8-1", "uniprot_id": "COA6_MOUSE", "mass": 9298.0, "length": 79, "protein_name": "Cytochrome c oxidase assembly factor 6 homolog", "gene_name": "Coa6", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor 6 homolog", "refseq_ac": "NP_778152", "gene_names_uniprotkb": "Coa6", "gene_names_refseq": "1810063B05Rik; Coa6", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 6 homolog", "protein_names_refseq": "cytochrome c oxidase assembly factor 6 homolog", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); COX deficiency, infantile mitochondrial myopathy (Disease Ontology:DOID:0050713); mitochondrial complex IV deficiency nuclear type 13 (Disease Ontology:DOID:0080360); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (mmu:67892)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18614015", "class_list": "", "function": "Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM15-1", "uniprot_id": "CF015_MOUSE", "mass": 36654.0, "length": 349, "protein_name": "Uncharacterized protein C6orf15 homolog", "gene_name": "Stg", "organism": "Mouse", "refseq_name": "uncharacterized protein C6orf15 homolog precursor", "refseq_ac": "NP_780357", "gene_names_uniprotkb": "Stg", "gene_names_refseq": "2300002M23Rik; Stg; emprin", "protein_names_uniprotkb": "Uncharacterized protein C6orf15 homolog; Emprin; Extracellular matrix protein with prion homology; Protein STG", "protein_names_refseq": "extracellular matrix protein with prion homology; uncharacterized protein C6orf15 homolog precursor; uncharacterized protein C6orf15 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69542)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18757743;22645316", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNI3;Q3KNI4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BM15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMK0-1", "uniprot_id": "CEP85_MOUSE", "mass": 85340.0, "length": 761, "protein_name": "Centrosomal protein of 85 kDa", "gene_name": "Cep85", "organism": "Mouse", "refseq_name": "centrosomal protein of 85 kDa", "refseq_ac": "NP_653110", "gene_names_uniprotkb": "Cep85; Ccdc21", "gene_names_refseq": "2410030J07Rik; Ccdc21; Cep85", "protein_names_uniprotkb": "Centrosomal protein of 85 kDa; Cep85; Coiled-coil domain-containing protein 21", "protein_names_refseq": "centrosomal protein of 85 kDa; coiled-coil domain containing 21; coiled-coil domain-containing protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:70012)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20173027;21183079;21750661;22872234;26220856;31219806;34203471;34428180;37828378", "class_list": "", "function": "Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility. Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity., [UniProtKB, UniProtKB]; Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A Erratum:[J Cell Sci. 2015 Oct 15;128(20):3837. doi: 10.1242/jcs.180463. PMID: 26471995], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUF1;Q8K0E6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0001764 neuron migration;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BMK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQH6-2", "uniprot_id": "CDCP2_MOUSE", "mass": 58575.0, "length": 540, "protein_name": "CUB domain-containing protein 2", "gene_name": "Cdcp2", "organism": "Mouse", "refseq_name": "CUB domain-containing protein 2 precursor", "refseq_ac": "NP_766461", "gene_names_uniprotkb": "Cdcp2", "gene_names_refseq": "Cdcp2; D030010E02Rik", "protein_names_uniprotkb": "CUB domain-containing protein 2", "protein_names_refseq": "CUB domain-containing protein 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:242603)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A1Y7VJ18", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQH6-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR90-1", "uniprot_id": "RIMC1_MOUSE", "mass": 33471.0, "length": 294, "protein_name": "RAB7A-interacting MON1-CCZ1 complex subunit 1", "gene_name": "Rimoc1", "organism": "Mouse", "refseq_name": "RAB7A-interacting MON1-CCZ1 complex subunit 1", "refseq_ac": "NP_666042", "gene_names_uniprotkb": "Rimoc1; AW549877", "gene_names_refseq": "Rimoc1", "protein_names_uniprotkb": "RAB7A-interacting MON1-CCZ1 complex subunit 1; UPF0600 protein C5orf51 homolog", "protein_names_refseq": "RAB7A-interacting MON1-CCZ1 complex subunit 1; UPF0600 protein C5orf51 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:106064)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A (By similarity). Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YM1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BR90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRU4-1", "uniprot_id": "CLC9A_MOUSE", "mass": 27014.0, "length": 238, "protein_name": "C-type lectin domain family 9 member A", "gene_name": "Clec9a", "organism": "Mouse", "refseq_name": "C-type lectin domain family 9 member A isoform 1", "refseq_ac": "NP_001192292", "gene_names_uniprotkb": "Clec9a; Dngr-1", "gene_names_refseq": "9830005G06Rik; Clec9a; DNGR-1", "protein_names_uniprotkb": "C-type lectin domain family 9 member A; Dendritic cell natural killer lectin group receptor 1", "protein_names_refseq": "C-type lectin domain family 9 member A isoform 1; dendritic cell natural killer lectin group receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232414)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18408006;18497879;18669894;19219027;22483802", "class_list": "glycogene", "function": "Analysis of differences between mouse and human Clec9A, [RefSeq, PubMed]; CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens, [RefSeq, PubMed]; CLEC9A functions as an activation receptor, [RefSeq, PubMed]; DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group GeneRIF: characterization of human and mouse CLEC9A (a.k.a DNGR-1), [RefSeq, PubMed]; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0ZBM3;B0ZBM5;B0ZBM6;B0ZBM7;Q5M8M6;Q8CBB4", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BRU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BT51-1", "uniprot_id": "COA4_MOUSE", "mass": 10135.0, "length": 87, "protein_name": "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial", "gene_name": "COA4", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor 4 homolog, mitochondrial", "refseq_ac": "NP_899093", "gene_names_uniprotkb": "COA4; Chchd8", "gene_names_refseq": "5330414O08Rik; Chchd8; Coa4; E2ig2", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 8", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain containing 8; coiled-coil-helix-coiled-coil-helix domain-containing protein 8; cytochrome c oxidase assembly factor 4 homolog, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68185)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Putative COX assembly factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA04", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BT51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTU1-1", "uniprot_id": "CFA20_MOUSE", "mass": 22748.0, "length": 193, "protein_name": "Cilia- and flagella-associated protein 20", "gene_name": "Cfap20", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 20", "refseq_ac": "NP_032213", "gene_names_uniprotkb": "Cfap20; Gtl3", "gene_names_refseq": "2600014O15Rik; Cfap20; Gtl3; T10-2A2", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 20; Gene trap locus 3 protein", "protein_names_refseq": "UPF0468 protein C16orf80 homolog; cilia- and flagella-associated protein 20; gene trap locus 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14894)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15803458;21750661;37295417;37865089;37989994;39853433;8688464", "class_list": "", "function": "Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:37295417, PubMed:37865089, PubMed:37989994). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417). Involved in the regulation of the size and morphology of cilia (By similarity). Required for axonemal microtubules polyglutamylation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70212;Q3T9D6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:2000253 positive regulation of feeding behavior;GO:2000147 positive regulation of cell motility;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BTU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60322-1", "uniprot_id": "NANO2_MOUSE", "mass": 15597.0, "length": 136, "protein_name": "Nanos homolog 2", "gene_name": "Nanos2", "organism": "Mouse", "refseq_name": "nanos homolog 2", "refseq_ac": "NP_918953", "gene_names_uniprotkb": "Nanos2; Nos2", "gene_names_refseq": "Nanos2; nos2", "protein_names_uniprotkb": "Nanos homolog 2; NOS-2", "protein_names_refseq": "NOS-2; nanos homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:378430)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12947200;14656712;16806845;17138666;18281459;19745153;20133598;25428506;35705038", "class_list": "", "function": "A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1., [RefSeq, PubMed]; Both in baseline conditions and during endotoxemia, the absence of NOS2 upregulated NOS1 and/or NOS3, which increased intestinal metabolism., [RefSeq, PubMed]; Cloning and functional analyses of nanos2 and nanos3; demonstrated an evolutionarily conserved function of nanos proteins in germ cell development [nanos2] [nanos3], [RefSeq, PubMed]; Nanos2 plays a role in the maintenance and differentiation of gonocytes/spermatogonia in neonatal testes, [RefSeq, PubMed]; Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ09", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0048477 oogenesis;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60322-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YV3-1", "uniprot_id": "TRRAP_MOUSE", "mass": 291557.0, "length": 2565, "protein_name": "Transformation/transcription domain-associated protein", "gene_name": "Trrap", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Trrap", "gene_names_refseq": "", "protein_names_uniprotkb": "Transformation/transcription domain-associated protein; Tra1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); autosomal dominant nonsyndromic deafness 75 (Disease Ontology:DOID:0112166)", "pathway": " (mmu:100683)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11544477;18299400;20173027;21750661;22872234;25605945;29187734;31219806;31231791;34428180;35820727;36210013", "class_list": "", "function": "Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0Z5;Q8K104", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80YV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27512-1", "uniprot_id": "TNR5_MOUSE", "mass": 32093.0, "length": 289, "protein_name": "Tumor necrosis factor receptor superfamily member 5", "gene_name": "Cd40", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 5 isoform 1 precursor", "refseq_ac": "NP_035741", "gene_names_uniprotkb": "Cd40; Tnfrsf5", "gene_names_refseq": "Bp50; Cd40; GP39; HIGM1; IGM; IMD3; T-BAM; TRAP; Tnfrsf5; p50", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor", "protein_names_refseq": "B-cell surface antigen CD40; CD40L receptor; T-cell differentiation antigen; tumor necrosis factor receptor superfamily member 5 isoform 1 precursor; tumor necrosis factor receptor superfamily member 5", "tax_id": 10090, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); tick-borne encephalitis (Disease Ontology:DOID:0050175); erythema multiforme (Disease Ontology:DOID:0050185); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); follicular lymphoma (Disease Ontology:DOID:0050873); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); immunodeficiency with hyper IgM type 3 (Disease Ontology:DOID:0060023); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colitis (Disease Ontology:DOID:0060180); atrial fibrillation (Disease Ontology:DOID:0060224); dermatomyositis (Disease Ontology:DOID:10223); pre-eclampsia (Disease Ontology:DOID:10591); membranous glomerulonephritis (Disease Ontology:DOID:10976); Graves' disease (Disease Ontology:DOID:12361); dilated cardiomyopathy (Disease Ontology:DOID:12930); Kawasaki disease (Disease Ontology:DOID:13378); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); hyperimmunoglobulin syndrome (Disease Ontology:DOID:2959); renal artery obstruction (Disease Ontology:DOID:2972); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); acute myocarditis (Disease Ontology:DOID:3951); allergic rhinitis (Disease Ontology:DOID:4481); Ehrlich tumor carcinoma (Disease Ontology:DOID:5050); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pulmonary hypertension (Disease Ontology:DOID:6432); B-cell lymphoma (Disease Ontology:DOID:707); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Burkitt lymphoma (Disease Ontology:DOID:8584); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); plasma cell leukemia (Disease Ontology:DOID:9513); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21939); (R-MMU-198933); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11172023;1281194;12881420;1370315;21750661;7533327;8790348", "class_list": "", "function": "Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420)., [UniProtKB, PubMed, UniProtKB]; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS33;Q3TSL2;Q3U799;Q3U7C9;Q3UBH3;Q542B1;Q8K2X6;Q99NE0;Q99NE1;Q99NE2;Q99NE3", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0003823 antigen binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002637 regulation of immunoglobulin production;GO:0023035 CD40 signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P27512-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10417-1", "uniprot_id": "BCL2_MOUSE", "mass": 26407.0, "length": 236, "protein_name": "Apoptosis regulator Bcl-2", "gene_name": "Bcl2", "organism": "Mouse", "refseq_name": "apoptosis regulator Bcl-2 isoform 1", "refseq_ac": "NP_033871", "gene_names_uniprotkb": "Bcl2; Bcl-2", "gene_names_refseq": "Bcl-2; Bcl2; C430015F12Rik; D630044D05Rik; D830018M01Rik", "protein_names_uniprotkb": "Apoptosis regulator Bcl-2", "protein_names_refseq": "apoptosis regulator Bcl-2 isoform 1; apoptosis regulator Bcl-2", "tax_id": 10090, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); follicular lymphoma (Disease Ontology:DOID:0050873); ductal carcinoma in situ (Disease Ontology:DOID:0060074); brain glioma (Disease Ontology:DOID:0060108); oligomeganephronia (Disease Ontology:DOID:0111142); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); dementia (Disease Ontology:DOID:1307); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); post-traumatic stress disorder (Disease Ontology:DOID:2055); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); transitional cell carcinoma (Disease Ontology:DOID:2671); bilirubin metabolic disorder (Disease Ontology:DOID:2741); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); plasmacytoma (Disease Ontology:DOID:3721); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intestinal disease (Disease Ontology:DOID:5295); lung small cell carcinoma (Disease Ontology:DOID:5409); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); retinal degeneration (Disease Ontology:DOID:8466); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); nasopharynx carcinoma (Disease Ontology:DOID:9261); priapism (Disease Ontology:DOID:9286); type 2 diabetes mellitus (Disease Ontology:DOID:9352); oral mucosa leukoplakia (Disease Ontology:DOID:9655); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12043); (R-MMU-111447); (R-MMU-111453); (R-MMU-844455)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "1508712;15781622;16509771;17418785;19606213;21502331;23223177;29020630;29915306;3032455;34428180;35183115;35702893;35820727;9115213;9738012;9852076", "class_list": "", "function": "Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)., [UniProtKB, PubMed, UniProtKB]; This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P10418;Q4VBF6", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0002360 T cell lineage commitment;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P10417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70326-1", "uniprot_id": "TBX5_MOUSE", "mass": 57832.0, "length": 518, "protein_name": "T-box transcription factor TBX5", "gene_name": "Tbx5", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX5", "refseq_ac": "NP_035667", "gene_names_uniprotkb": "Tbx5", "gene_names_refseq": "Tbx5", "protein_names_uniprotkb": "T-box transcription factor TBX5; T-box protein 5", "protein_names_refseq": "T-box protein 5; T-box transcription factor TBX5", "tax_id": 10090, "disease": "Holt-Oram syndrome (Disease Ontology:DOID:0060468); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:21388); (R-MMU-2032785)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10373308;21750661;35820727;8853987;8878690", "class_list": "", "function": "DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R003", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0003166 bundle of His development;GO:0060929 atrioventricular node cell fate commitment;GO:0051891 positive regulation of cardioblast differentiation;GO:0003167 atrioventricular bundle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YUJ3-1", "uniprot_id": "CCYL1_MOUSE", "mass": 41600.0, "length": 367, "protein_name": "Cyclin-Y-like protein 1", "gene_name": "Ccnyl1", "organism": "Mouse", "refseq_name": "cyclin-Y-like protein 1", "refseq_ac": "NP_001091113", "gene_names_uniprotkb": "Ccnyl1", "gene_names_refseq": "9630037P07Rik; Ccnyl1", "protein_names_uniprotkb": "Cyclin-Y-like protein 1", "protein_names_refseq": "cyclin-Y-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227210)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21750661;26305884;26590424;27203244;34431536", "class_list": "", "function": "CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16. Erratum:[PLoS Genet. 2019 Mar 4;15(3):e1008021. doi: 10.1371/journal.pgen.1008021. PMID: 30830908] Publication Status: Online-Only, [RefSeq, PubMed]; Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5 Publication Status: Online-Only, [RefSeq, PubMed]; Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development (PubMed:26305884, PubMed:26590424, PubMed:34431536). Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation (PubMed:26305884, PubMed:26590424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q226", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0016055 Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3YUJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMA4-1", "uniprot_id": "FFAR4_MOUSE", "mass": 40813.0, "length": 361, "protein_name": "Free fatty acid receptor 4", "gene_name": "Ffar4", "organism": "Mouse", "refseq_name": "free fatty acid receptor 4", "refseq_ac": "NP_861413", "gene_names_uniprotkb": "Ffar4; Gpr120; O3far1", "gene_names_refseq": "Ffa4; Ffar4; GT01; Gpr120; Gpr129; KPG_013; O3far1; Pgr4", "protein_names_uniprotkb": "Free fatty acid receptor 4; G protein-coupled receptor 120; G protein-coupled receptor GT01; Omega-3 fatty acid receptor 1", "protein_names_refseq": "G-protein coupled receptor 120; G-protein-coupled receptor GT01; free fatty acid receptor 4; omega-3 fatty acid receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107221); (R-MMU-381771); (R-MMU-416476)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "14623098;15619630;15774482;17250804;19071193;20573884;20813258;22343897;24222669;24663807;24742677;25535828;26365922;26873857;27852822;27853148;29343498;31761534;38760332", "class_list": "", "function": "G protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G protein and beta-arrestin pathways (PubMed:26873857, PubMed:27852822). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:26873857, PubMed:27852822). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:26873857, PubMed:27852822). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (PubMed:17250804, PubMed:22343897, PubMed:27853148, PubMed:29343498, PubMed:31761534). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (PubMed:31761534). Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone (PubMed:27853148, PubMed:29343498). Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue (PubMed:27853148, PubMed:29343498). Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (PubMed:29343498). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (PubMed:29343498). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (PubMed:26365922). In response to dietary fats regulates hormone secretion and appetite (PubMed:15619630, PubMed:24222669, PubMed:24663807, PubMed:24742677, PubMed:25535828). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (PubMed:15619630, PubMed:24742677, PubMed:25535828). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (PubMed:24663807). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (PubMed:24222669). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (PubMed:20573884). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (PubMed:20813258). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (PubMed:20813258). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (PubMed:15774482). Mediates VLCFAs-dependent liver-to-adipose tissue signaling and adipose tissue thermogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Regulates adipogenic processes such as adipocyte development and differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005504 fatty acid binding;GO:1990763 arrestin family protein binding;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q7TMA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35305-1", "uniprot_id": "TNR11_MOUSE", "mass": 66621.0, "length": 625, "protein_name": "Tumor necrosis factor receptor superfamily member 11A", "gene_name": "Tnfrsf11a", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 11A precursor", "refseq_ac": "NP_033425", "gene_names_uniprotkb": "Tnfrsf11a; Rank", "gene_names_refseq": "Ly109; ODFR; OFE; Rank; TRANCE-R; Tnfrsf11a; mRANK", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 11A; ODFR; Osteoclast differentiation factor receptor; Receptor activator of NF-KB", "protein_names_refseq": "osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of NF-kappaB; tumor necrosis factor receptor superfamily member 11A precursor", "tax_id": 10090, "disease": "bone development disease (Disease Ontology:DOID:0080006); Paget's disease of bone 2 (Disease Ontology:DOID:0081365); autosomal recessive osteopetrosis 7 (Disease Ontology:DOID:0110946); familial expansile osteolysis (Disease Ontology:DOID:0111542); stomach cancer (Disease Ontology:DOID:10534); osteoporosis (Disease Ontology:DOID:11476); Paget's disease of bone (Disease Ontology:DOID:5408); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:21934); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;20483727;23039992;23478294;29348675;9367155;9878548", "class_list": "", "function": "Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:20483727, PubMed:23478294, PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Involved in the regulation of interactions between T-cells and dendritic cells (PubMed:9367155)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCT7", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005031 tumor necrosis factor receptor activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0060086 circadian temperature homeostasis;GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPI1-1", "uniprot_id": "KTU_MOUSE", "mass": 88327.0, "length": 814, "protein_name": "Protein kintoun", "gene_name": "Dnaaf2", "organism": "Mouse", "refseq_name": "protein kintoun", "refseq_ac": "NP_081545", "gene_names_uniprotkb": "Dnaaf2; Ktu", "gene_names_refseq": "Dnaaf2; Ktu; TU54; kintoun; mknt", "protein_names_uniprotkb": "Protein kintoun; Dynein assembly factor 2, axonemal", "protein_names_refseq": "dynein assembly factor 2, axonemal; protein kintoun", "tax_id": 10090, "disease": "primary ciliary dyskinesia 10 (Disease Ontology:DOID:0110612)", "pathway": " (mmu:109065)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19052621;19224205;20173027;23525783;31107948;34418053", "class_list": "", "function": "Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment, [RefSeq, PubMed]; Observation of cilia orientation based on basal foot directions revealed that ciliary motility was not required in the alignment of airway cilia, whereas a strong requirement was observed in brain ependymal cells., [RefSeq, PubMed]; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [UniProtKB, HAMAP]; These findings support studies indicating that hypomorphic mutations of human DNAAF2 can result in ciliary dyskinesia and identify Dnaaf2 as an essential component of cilia function in vivo., [RefSeq, PubMed]; This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in the human gene have been associated with primary ciliary dyskinesia. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9I8;Q3U4G5;Q6P5G9;Q9CZC7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0032526 response to retinoic acid;GO:0036158 outer dynein arm assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BPI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97458-1", "uniprot_id": "PROP1_MOUSE", "mass": 25025.0, "length": 223, "protein_name": "Homeobox protein prophet of Pit-1", "gene_name": "Prop1", "organism": "Mouse", "refseq_name": "homeobox protein prophet of Pit-1", "refseq_ac": "NP_032962", "gene_names_uniprotkb": "Prop1; Prop-1", "gene_names_refseq": "Prop-1; Prop1; df", "protein_names_uniprotkb": "Homeobox protein prophet of Pit-1; PROP-1; Pituitary-specific homeodomain factor", "protein_names_refseq": "Ames dwarf; homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; prophet of Pit-1", "tax_id": 10090, "disease": "combined pituitary hormone deficiency 2 (Disease Ontology:DOID:0061020); hypogonadism (Disease Ontology:DOID:1924); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (mmu:19127)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10946881;21750661;8934515", "class_list": "", "function": "Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCG9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0060126 somatotropin secreting cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35917-1", "uniprot_id": "VGFR3_MOUSE", "mass": 153016.0, "length": 1363, "protein_name": "Vascular endothelial growth factor receptor 3", "gene_name": "Flt4", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor receptor 3 precursor", "refseq_ac": "NP_032055", "gene_names_uniprotkb": "Flt4; Flt-4; Vegfr3", "gene_names_refseq": "Chy; Flt-4; Flt4; VEGFR-3; VEGFR3", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 3; 2.7.10.1; FLT-4; Fms-like tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4; VEGFR-3", "protein_names_refseq": "chylous ascites; receptor protein tyrosine kinase; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3 precursor; vascular endothelial growth factor receptor 3", "tax_id": 10090, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); hereditary lymphedema IA (Disease Ontology:DOID:0070210); lymphangioma (Disease Ontology:DOID:1475); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (mmu:14257); (R-MMU-195399)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;1319394;16944957;18594512;20445537;20697430;21481239;21909098;28179430;31599954;34428180;8393164;9794766", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 88, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0003016 respiratory system process;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQF3-1", "uniprot_id": "CPSF5_MOUSE", "mass": 26240.0, "length": 227, "protein_name": "Cleavage and polyadenylation specificity factor subunit 5", "gene_name": "Nudt21", "organism": "Mouse", "refseq_name": "cleavage and polyadenylation specificity factor subunit 5", "refseq_ac": "NP_080899", "gene_names_uniprotkb": "Nudt21; Cpsf5", "gene_names_refseq": "25kDa; 3110048P04Rik; 5730530J16Rik; Cpsf5; Nudt21", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 5; Nucleoside diphosphate-linked moiety X motif 21; Nudix hydrolase 21; Nudix motif 21", "protein_names_refseq": "cleavage and polyadenylation specific factor 5, 25 kD subunit; cleavage and polyadenylation specificity factor subunit 5; nucleoside diphosphate-linked moiety X motif 21; nudix (nucleoside diphosphate linked moiety X)-type motif 21; nudix motif 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:68219); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11716503;18032416;21750661;23806337;24129315;29249356;31219806", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Pre-messenger RNA cleavage factor I (CFIm): potential role in alternative polyadenylation during spermatogenesis. GeneRIF: Here we report that the CFIm subunits NUDT21/CPSF5 and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJK1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016604 nuclear body;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0051262 protein tetramerization;GO:0010608 post-transcriptional regulation of gene expression;GO:0051290 protein heterotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03146-1", "uniprot_id": "DDR1_MOUSE", "mass": 101161.0, "length": 911, "protein_name": "Epithelial discoidin domain-containing receptor 1", "gene_name": "Ddr1", "organism": "Mouse", "refseq_name": "epithelial discoidin domain-containing receptor 1 isoform 1 precursor", "refseq_ac": "NP_001185760", "gene_names_uniprotkb": "Ddr1; Cak; Eddr1; Mpk6", "gene_names_refseq": "6030432F18; CD167a; Cak; Ddr1; Nep; PTK3A", "protein_names_uniprotkb": "Epithelial discoidin domain-containing receptor 1; 2.7.10.1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Protein-tyrosine kinase MPK-6; Tyrosine kinase DDR; Tyrosine-protein kinase CAK", "protein_names_refseq": "CD167 antigen-like family member A; cell adhesion kinase; discoidin receptor tyrosine kinase; epithelial discoidin domain receptor 1; epithelial discoidin domain-containing receptor 1 isoform 1 precursor; epithelial discoidin domain-containing receptor 1; protein-tyrosine kinase MPK-6; tyrosine kinase DDR; tyrosine-protein kinase CAK", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); alcoholic hepatitis (Disease Ontology:DOID:12351); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:12305); (R-MMU-3000171)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11283268;12065315;1281307;15200417;18026164;21750661;37201403;37373466;37709489;8622863", "class_list": "", "function": "Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer., [RefSeq, PubMed]; Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration., [RefSeq, PubMed]; Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0038062 protein tyrosine kinase collagen receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0061302 smooth muscle cell-matrix adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q03146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35144-1", "uniprot_id": "TERF2_MOUSE", "mass": 60263.0, "length": 541, "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "Terf2", "organism": "Mouse", "refseq_name": "telomeric repeat-binding factor 2 isoform 2", "refseq_ac": "NP_001076587", "gene_names_uniprotkb": "Terf2; Trf2", "gene_names_refseq": "TRF2; Terf2", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein", "protein_names_refseq": "TTAGGG repeat-binding factor 2; telomeric DNA-binding protein; telomeric repeat-binding factor 2 isoform 2", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427)", "pathway": " (mmu:21750); (R-MMU-110330); (R-MMU-110331); (R-MMU-171319); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174430); (R-MMU-174437); (R-MMU-2559586); (R-MMU-9670095)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;20339076;20619712;20622870;21183079;21750661;28216226;30084848;31219806;34428180;34883513;39128227;9326950", "class_list": "", "function": "Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:20339076, PubMed:20619712, PubMed:20622870, PubMed:28216226). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (By similarity). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (By similarity). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (By similarity). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:28216226). Preferentially binds to positive supercoiled DNA (By similarity). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (By similarity). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (PubMed:20339076, PubMed:20619712, PubMed:20622870)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat., [UniProtKB, UniProtKB]; Role of the telomeric factor TRF2 in post-hypoxic brain damages., [RefSeq, PubMed]; TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YVG5;Q80VE2;Q8BQJ9", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0042162 telomeric DNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon;GO:0016604 nuclear body;GO:0000783 nuclear telomere cap complex", "go_biological_process": "GO:0032205 negative regulation of telomere maintenance;GO:0032204 regulation of telomere maintenance;GO:1904430 negative regulation of t-circle formation;GO:0001701 in utero embryonic development;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35144-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLV5-1", "uniprot_id": "CUL3_MOUSE", "mass": 88948.0, "length": 768, "protein_name": "Cullin-3", "gene_name": "Cul3", "organism": "Mouse", "refseq_name": "cullin-3 isoform 2 precursor", "refseq_ac": "NP_001300657", "gene_names_uniprotkb": "Cul3", "gene_names_refseq": "Cul3; KIAA0617", "protein_names_uniprotkb": "Cullin-3; CUL-3", "protein_names_refseq": "cullin-3 isoform 2 precursor", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with or without autism or seizures (Disease Ontology:DOID:0061147); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (mmu:26554); (R-MMU-4641258); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-8951664); (R-MMU-9013418); (R-MMU-9013422); (R-MMU-9706019); (R-MMU-9755511); (R-MMU-983168); (R-MMU-9929491)", "pathway_count": 11, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10500095;12193649;14764894;15282312;16162871;16790436;17339333;21750661;22358839;22645316;24788674;25605945;27697860;27708159;28135057;30779550;31219806;34203471;34428180;34491895;36210013;37507081;37558490;37913946;39430237", "class_list": "", "function": "Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component (By similarity). BCR(KLHL42) is involved in ubiquitination of KATNA1 (By similarity). BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3 (By similarity). Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity (By similarity). BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4 (By similarity). The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (By similarity). The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity). The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway (By similarity). The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) (By similarity). The BCR(KLHL25) ubiquitin ligase complex is also involved in lipid synthesis by mediating ubiquitination and degradation of ACLY (PubMed:34491895). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (By similarity). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:12193649, PubMed:14764894, PubMed:15282312). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (By similarity). The BCR(KBTBD4) E3 ubiquitin ligase complex targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation with RCOR1 likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (By similarity). It also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 with degradation being dependent on the presence of an ELM2 domain in the target proteins (By similarity). The BCR(ARMC5) complex mediates premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation by mediating ubiquitination of Pol II subunit POLR2A (By similarity). Required for 'Lys-63'-linked ubiquitination of large ribosomal subunit protein MRPL12 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination., [RefSeq, PubMed]; Data show that the constitutive degradation pathway for cyclin E that is regulated by the Cullin3-based E3 ligase is essential to maintain quiescence in mammalian cells., [RefSeq, PubMed]; Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons., [RefSeq, PubMed]; PRDX1 inhibits ferroptosis by binding to Cullin-3 as a molecular chaperone in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0005112 Notch binding;GO:0061630 ubiquitin protein ligase activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1900076 regulation of cellular response to insulin stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9JLV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U595-1", "uniprot_id": "CV039_MOUSE", "mass": 12503.0, "length": 105, "protein_name": "Synaptic plasticity regulator PANTS", "gene_name": "2510002D24Rik", "organism": "Mouse", "refseq_name": "synaptic plasticity regulator PANTS", "refseq_ac": "NP_001028336", "gene_names_uniprotkb": "2510002D24Rik", "gene_names_refseq": "2410043I01Rik; 2510002D24Rik; DXMgi27; Pants", "protein_names_uniprotkb": "Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short", "protein_names_refseq": "UPF0545 protein C22orf39 homolog; plasticity-associated neural transcript; synaptic plasticity regulator PANTS", "tax_id": 10090, "disease": "", "pathway": " (mmu:72307)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29571919;35771867", "class_list": "", "function": "Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867). Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867). Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:1900272 negative regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0D0-1", "uniprot_id": "CDK17_MOUSE", "mass": 59506.0, "length": 523, "protein_name": "Cyclin-dependent kinase 17", "gene_name": "Cdk17", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 17", "refseq_ac": "NP_666351", "gene_names_uniprotkb": "Cdk17; Pctaire2; Pctk2", "gene_names_refseq": "6430598J10Rik; Cdk17; Pctk2", "protein_names_uniprotkb": "Cyclin-dependent kinase 17; 2.7.11.22; Cell division protein kinase 17; PCTAIRE-motif protein kinase 2; Serine/threonine-protein kinase PCTAIRE-2", "protein_names_refseq": "PCTAIRE-motif protein kinase 2; Pctaire2; cell division protein kinase 17; cyclin-dependent kinase 17; serine/threonine-protein kinase PCTAIRE-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:237459)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11527406;19144319;21183079;21750661;26885753", "class_list": "", "function": "May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1901987 regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K0D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHC7-1", "uniprot_id": "DAB2P_MOUSE", "mass": 131726.0, "length": 1189, "protein_name": "Disabled homolog 2-interacting protein", "gene_name": "Dab2ip", "organism": "Mouse", "refseq_name": "disabled homolog 2-interacting protein isoform 3", "refseq_ac": "NP_001001602", "gene_names_uniprotkb": "Dab2ip; Kiaa1743", "gene_names_refseq": "2310011D08Rik; Aip1; Dab2ip; mKIAA1743", "protein_names_uniprotkb": "Disabled homolog 2-interacting protein; ASK-interacting protein 1; DAB2-interacting protein; DOC-2/DAB-2 interactive protein", "protein_names_refseq": "ASK-interacting protein 1; ASK1-interacting protein 1; DAB2-interacting protein; DOC-2/DAB-2 interactive protein; disabled 2 interacting protein long form; disabled homolog 2-interacting protein isoform 3; disabled homolog 2-interacting protein", "tax_id": 10090, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); developmental disorder of mental health (Disease Ontology:DOID:0060037); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (mmu:69601); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 35, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;12877983;16629596;18281285;18299400;19033661;19903888;19948740;20080667;20154697;20173027;21183079;21700930;21750661;22645316;22696229;22872234;23056358;23326475;25428506;30084848;30779550;33166004;33789142;34203471;34428180;34678516;35524333;35820727;35822049;36210013;36852467;36947637;40885482", "class_list": "", "function": "AIP1 is essential for transducing the IRE1-mediated endoplasmic reticulum stress response., [RefSeq, PubMed]; AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model. Publication Status: Online-Only, [RefSeq, PubMed]; Astaxanthin mediated regulation of VEGF through HIF1alpha and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model., [RefSeq, PubMed]; DAB2IP-knocking down resulted in radio-resistance of breast cancer cells is associated with increased hypoxia and vasculogenic mimicry formation., [RefSeq, PubMed]; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and gammaH2A.X phosphorylation., [RefSeq, PubMed]; This study suggests that Dab2IP may function as a downstream effector in the Reelin signaling pathway that influences Ras signaling during brain development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AUW9;A2AUX2;A5X2X2;B7ZD28;Q3TPD5;Q3UH44;Q6JTV1;Q6Y636;Q80T97", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0010633 negative regulation of epithelial cell migration;GO:0046580 negative regulation of Ras protein signal transduction;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "Q3UHC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TUL7-1", "uniprot_id": "DCA17_MOUSE", "mass": 58400.0, "length": 519, "protein_name": "DDB1- and CUL4-associated factor 17", "gene_name": "Dcaf17", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 17 isoform a", "refseq_ac": "NP_001159452", "gene_names_uniprotkb": "Dcaf17", "gene_names_refseq": "2810055O12Rik; 4833418A01Rik; A030004A10Rik; A930009G19Rik; Dcaf17", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 17", "protein_names_refseq": "DDB1- and CUL4-associated factor 17 isoform a", "tax_id": 10090, "disease": "Woodhouse-Sakati syndrome (Disease Ontology:DOID:0112264)", "pathway": " (mmu:75763); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19026396;21750661;29178422;29907856;34428180;36509865", "class_list": "", "function": "A mouse model mimicking loss of function in exon 2 of Dcaf17 was generated using CRISPR/Cas9 and showed female subfertility and male infertility., [RefSeq, PubMed]; Disruption of Dcaf17 caused asymmetric acrosome capping, impaired nuclear compaction and abnormal round spermatid to elongated spermatid transition. For the first time, these data indicate that DCAF17 is essential for spermiogenesis. Erratum:[Sci Rep. 2018 Aug 1;8(1):11779. doi: 10.1038/s41598-018-29836-2. PMID: 30068992] Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of male fertility-critical Dcaf17 dysregulates mouse testis transcriptome. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUU6;Q8C002;Q8K0F5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0000902 cell morphogenesis;GO:0016567 protein ubiquitination;GO:0001675 acrosome assembly;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TUL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMT4-1", "uniprot_id": "LRC33_MOUSE", "mass": 77140.0, "length": 693, "protein_name": "Transforming growth factor beta activator LRRC33", "gene_name": "Nrros", "organism": "Mouse", "refseq_name": "transforming growth factor beta activator LRRC33 isoform 2 precursor", "refseq_ac": "NP_001334110", "gene_names_uniprotkb": "Nrros; Lrrc33", "gene_names_refseq": "E430025L02Rik; Lrcc33; Lrrc33; Nrros", "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species", "protein_names_refseq": "leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; transforming growth factor beta activator LRRC33 isoform 2 precursor; transforming growth factor beta activator LRRC33", "tax_id": 10090, "disease": "", "pathway": " (mmu:224109)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24550525;24739962;25605945;26740625;27802388;28011936;28459434;28935714;29909984;30084848;30779550;31219806;32100099;34428180", "class_list": "", "function": "Biallelic mutations in NRROS cause an early onset lethal microgliopathy., [RefSeq, PubMed]; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (PubMed:29909984). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (PubMed:29909984). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (PubMed:29909984). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage, [RefSeq, PubMed]; Results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIA8;Q8BTT4;Q8BUI7;Q8BY16;Q8R063", "ec_number_list": "", "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0014005 microglia development;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q8BMT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27699-1", "uniprot_id": "CREM_MOUSE", "mass": 38516.0, "length": 357, "protein_name": "cAMP-responsive element modulator", "gene_name": "Crem", "organism": "Mouse", "refseq_name": "cAMP-responsive element modulator isoform 4", "refseq_ac": "NP_001104320", "gene_names_uniprotkb": "Crem", "gene_names_refseq": "Crem; ICERI; ICER", "protein_names_uniprotkb": "cAMP-responsive element modulator; ICER; Inducible cAMP early repressor", "protein_names_refseq": "cAMP responsive element moderator; cAMP-responsive element modulator isoform 4; inducible cAMP early repressor", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:12916)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10086359;1370576;16059773;16595651;1847666;21183079;21750661;23443664;26940607;31219806;34428180;35820727;38199433;39177342;40997131;8252624", "class_list": "", "function": "Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation., [RefSeq, PubMed]; Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter., [UniProtKB, PubMed, PubMed]; This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]., [RefSeq]; Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651)., [UniProtKB, PubMed]; [Expression of the CREM gene in the semen and testis of miR-199b-5p knockout male mice]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27698;Q5XTP8;Q5XTP9;Q5XTQ0;Q5XTQ1;Q5XTQ2;Q5XTQ3;Q99JF1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P27699-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESN5-1", "uniprot_id": "CENPK_MOUSE", "mass": 31686.0, "length": 271, "protein_name": "Centromere protein K", "gene_name": "Cenpk", "organism": "Mouse", "refseq_name": "centromere protein K isoform 1", "refseq_ac": "NP_068562", "gene_names_uniprotkb": "Cenpk; Solt", "gene_names_refseq": "B130045K24Rik; C530004N04Rik; Cenp-K; Cenpk; Solt; Solzt", "protein_names_uniprotkb": "Centromere protein K; CENP-K; SoxLZ/Sox6 leucine zipper-binding protein in testis", "protein_names_refseq": "SoxLZ/Sox6 leucine zipper binding protein in testis; centromere protein K isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:60411); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "10996314;21750661", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXA9;Q569Q3;Q8C469", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2V6-1", "uniprot_id": "HDAC5_MOUSE", "mass": 120942.0, "length": 1113, "protein_name": "Histone deacetylase 5", "gene_name": "Hdac5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Hdac5", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase 5; 3.5.1.98; HD5; Histone deacetylase mHDA1", "protein_names_refseq": "", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-MMU-350054)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10640276;10984530;11022042;15060175;15140878;15546868;15601857;17468767;17949687;18711143;21454484;21750661;22730529;23624624;34428180;39659899;9891014", "class_list": "", "function": "In vitro, it deacetylates core histones (PubMed:10984530, PubMed:9891014). Deacetylates lysine residues on the N-terminal part of the histones H2A, H2B, H3 and H4 (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). Serves as a corepressor of RARA and causes its deacetylation (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL73", "ec_number_list": "3.5.1.-;3.5.1.98;3.5.1.48;3.5.1.62", "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:2000648 positive regulation of stem cell proliferation;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0048742 regulation of skeletal muscle fiber development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9Z2V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3L8-1", "uniprot_id": "CDK8_MOUSE", "mass": 53210.0, "length": 464, "protein_name": "Cyclin-dependent kinase 8", "gene_name": "Cdk8", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 8 isoform 1", "refseq_ac": "NP_705827", "gene_names_uniprotkb": "Cdk8", "gene_names_refseq": "Cdk8", "protein_names_uniprotkb": "Cyclin-dependent kinase 8; 2.7.11.22; 2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8", "protein_names_refseq": "cell division protein kinase 8; cyclin-dependent kinase 8 isoform 1; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:264064); (R-MMU-2173796)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;23352233;29237092;31219806;32782141;32848054;36852467;37235474;39390295;40885482", "class_list": "", "function": "Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity). Selectively regulates the interferon response by phosphorylating the transcription factor STAT1 transactivation domain (PubMed:23352233)., [UniProtKB, UniProtKB, PubMed]; Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.3.1.48;2.3.1.-;3.1.13.1;3.6.4.13;5.6.2.6;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;1.14.11.68;2.7.11.2;2.7.11.10;3.5.1.-;3.5.1.98;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;1.14.19.1;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;6.2.1.3;6.2.1.24;6.2.1.15;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;6.2.1.1;6.2.1.17;2.7.11.31;3.6.5.-;2.3.1.15;2.1.1.364;4.1.1.32;2.3.1.199;2.7.11.38;2.3.1.51;3.6.1.-;3.6.-.-;2.3.1.20;2.3.1.76;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000151 ubiquitin ligase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090209 negative regulation of triglyceride metabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R3L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXV9-1", "uniprot_id": "DCNL5_MOUSE", "mass": 27579.0, "length": 237, "protein_name": "DCN1-like protein 5", "gene_name": "Dcun1d5", "organism": "Mouse", "refseq_name": "DCN1-like protein 5 isoform 2", "refseq_ac": "NP_084051", "gene_names_uniprotkb": "Dcun1d5; SCCRO5", "gene_names_refseq": "3110001A18Rik; 4833420K19Rik; D430047L21Rik; DCNL5; Dcun1d5", "protein_names_uniprotkb": "DCN1-like protein 5; DCNL5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5; Squamous cell carcinoma-related oncogene 5", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 5; DCN1-like protein 5 isoform 2; DCN1-like protein 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; squamous cell carcinoma-related oncogene 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76863); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;26792857;26906416;29958295;31219806", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26792857). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XKI2;Q9CUS4", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CXV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7W7-1", "uniprot_id": "DCR1B_MOUSE", "mass": 61069.0, "length": 541, "protein_name": "5' exonuclease Apollo", "gene_name": "Dclre1b", "organism": "Mouse", "refseq_name": "5' exonuclease Apollo isoform b", "refseq_ac": "NP_001020483", "gene_names_uniprotkb": "Dclre1b; Snm1b", "gene_names_refseq": "Apollo; Dclre1b; SNMIB; mSNM1B", "protein_names_uniprotkb": "5' exonuclease Apollo; 3.1.-.-; 3.5.2.6; Beta-lactamase MBLAC2; DNA cross-link repair 1B protein; SNM1 homolog B", "protein_names_refseq": "5' exonuclease Apollo isoform b; 5' exonuclease Apollo; DNA cross-link repair 1B protein; DNA cross-link repair 1B, PSO2 homolog; SNM1 homolog B; beta-lactamase MBLAC2", "tax_id": 10090, "disease": "dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (mmu:140917); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20551906;20619712;20854421;21750661;22748632;31219806;34428180", "class_list": "", "function": "5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication., [RefSeq, PubMed]; Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated., [RefSeq, PubMed]; TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion., [RefSeq, PubMed]; The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLW2;B0V3N9;B0V3P0;Q3U4P2;Q3UUC7;Q3UV92;Q6NXL4;Q8BN95;Q8BQS8;Q921S0", "ec_number_list": "3.4.13.19;3.5.2.6;3.1.21.-;3.1.4.1;3.6.4.13;3.4.19.12;3.1.2.2;3.1.-.-;3.1.22.-;2.3.2.27", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016604 nuclear body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0031848 protection from non-homologous end joining at telomere;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C7W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09793-1", "uniprot_id": "CTLA4_MOUSE", "mass": 24993.0, "length": 223, "protein_name": "Cytotoxic T-lymphocyte protein 4", "gene_name": "Ctla4", "organism": "Mouse", "refseq_name": "cytotoxic T-lymphocyte protein 4 isoform 1 precursor", "refseq_ac": "NP_033973", "gene_names_uniprotkb": "Ctla4; Cd152", "gene_names_refseq": "Cd152; Ctla-4; Ctla4; Ly-56", "protein_names_uniprotkb": "Cytotoxic T-lymphocyte protein 4; CTLA-4; Cytotoxic T-lymphocyte-associated antigen 4", "protein_names_refseq": "CD152 antigen; cytotoxic T-lymphocyte protein 4 isoform 1 precursor; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated antigen 4", "tax_id": 10090, "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); latent autoimmune diabetes in adults (Disease Ontology:DOID:0080846); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); silicosis (Disease Ontology:DOID:10325); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); hepatitis A (Disease Ontology:DOID:12549); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); urinary schistosomiasis (Disease Ontology:DOID:1394); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune hemolytic anemia (Disease Ontology:DOID:718); autoimmune thyroiditis (Disease Ontology:DOID:7188); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:12477); (R-MMU-389356); (R-MMU-389513)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10493833;11052947;11465105;1713603;21750661;23400950;3496540;39456030;9256472;9712716", "class_list": "", "function": "High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The soluble isoform of CTLA-4 is a regulator of T-cell responses., [RefSeq, PubMed]; This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 49, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZZ7", "ec_number_list": "", "go_molecular_function": "GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0045334 clathrin-coated endocytic vesicle", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0006974 DNA damage response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09158-1", "uniprot_id": "CP3AP_MOUSE", "mass": 58122.0, "length": 503, "protein_name": "Cytochrome P450 3A25", "gene_name": "Cyp3a25", "organism": "Mouse", "refseq_name": "cytochrome P450 3A25", "refseq_ac": "NP_062766", "gene_names_uniprotkb": "Cyp3a25", "gene_names_refseq": "Cyp3a25", "protein_names_uniprotkb": "Cytochrome P450 3A25; 1.14.14.1; CYPIIIA25", "protein_names_refseq": "CYPIIIA25; cytochrome P450 3A25; cytochrome P450, 3a25", "tax_id": 10090, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); oral submucous fibrosis (Disease Ontology:DOID:5773); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:56388); (R-MMU-211945); (R-MMU-211958); (R-MMU-211981); (R-MMU-5423646); (R-MMU-9027307); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "21750661;30084848;34428180", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009617 response to bacterium;GO:0070989 oxidative demethylation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O09158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSG2-1", "uniprot_id": "CTDP1_MOUSE", "mass": 104554.0, "length": 960, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "gene_name": "Ctdp1", "organism": "Mouse", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "refseq_ac": "NP_080571", "gene_names_uniprotkb": "Ctdp1; Fcp1", "gene_names_refseq": "4930563P03Rik; Ctdp1", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase; 3.1.3.16; TFIIF-associating CTD phosphatase", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; RNA polymerase II subunit A C-terminal domain phosphatase; TFIIF-associating CTD phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67655); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;23806337;33408128;34428180;39627609", "class_list": "", "function": "Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Publication Status: Online-Only, [RefSeq, PubMed]; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSS7;Q9D4S8", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;5.6.2.4;3.1.3.74;3.1.3.53;2.7.11.22;2.7.11.23;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0030957 Tat protein binding;GO:0001096 TFIIF-class transcription factor complex binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0051301 cell division;GO:0006470 protein dephosphorylation;GO:0010458 exit from mitosis;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TSG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZN9-1", "uniprot_id": "CX6B2_MOUSE", "mass": 10521.0, "length": 88, "protein_name": "Cytochrome c oxidase subunit 6B2", "gene_name": "Cox6b2", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 6B2 isoform 1", "refseq_ac": "NP_001276777", "gene_names_uniprotkb": "Cox6b2", "gene_names_refseq": "1700067P11Rik; COXVIB2; Cox6b2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6B2; COX VIb-2; Cytochrome c oxidase subunit VIb isoform 2; Cytochrome c oxidase subunit VIb, testis-specific isoform", "protein_names_refseq": "cytochrome c oxidase subunit 6B2 isoform 1; cytochrome c oxidase subunit VIb polypeptide 2", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:333182); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12874793;21750661;37423748", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]; Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNG2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045277 respiratory chain complex IV;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0030154 cell differentiation;GO:0006754 ATP biosynthetic process;GO:0001890 placenta development;GO:0006119 oxidative phosphorylation;GO:0017145 stem cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80ZN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TT8-1", "uniprot_id": "CUL9_MOUSE", "mass": 282499.0, "length": 2530, "protein_name": "Cullin-9", "gene_name": "Cul9", "organism": "Mouse", "refseq_name": "cullin-9", "refseq_ac": "NP_001074804", "gene_names_uniprotkb": "Cul9; Kiaa0708; Parc", "gene_names_refseq": "1810035I07Rik; Cul-9; Cul9; Parc; mKIAA0708", "protein_names_uniprotkb": "Cullin-9; CUL-9; p53-associated parkin-like cytoplasmic protein", "protein_names_refseq": "cullin-9; p53-associated parkin-like cytoplasmic protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78309)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15964813;16672220;21487039;21750661;24793696;27678504;33037272", "class_list": "", "function": "Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of the Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (By similarity). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity and the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (By similarity). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (By similarity). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (By similarity). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Dimerization of Cul7 and Parc is not required for all Cul7 functions and mouse development., [RefSeq, PubMed]; FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2, [RefSeq, PubMed]; The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKL9;Q8CGC0;Q8R363;S4R1Y1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031461 cullin-RING ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000226 microtubule cytoskeleton organization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80TT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ07-1", "uniprot_id": "DPOLN_MOUSE", "mass": 96675.0, "length": 864, "protein_name": "DNA polymerase nu", "gene_name": "Poln", "organism": "Mouse", "refseq_name": "DNA polymerase nu isoform 3", "refseq_ac": "NP_001276733", "gene_names_uniprotkb": "Poln", "gene_names_refseq": "POL4P; Poln", "protein_names_uniprotkb": "DNA polymerase nu; 2.7.7.7", "protein_names_refseq": "DNA polymerase nu isoform 3; DNA-directed DNA polymerase nu", "tax_id": 10090, "disease": "", "pathway": " (mmu:272158); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12794064;21750661;28570559;31219806;35820727", "class_list": "", "function": "DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence. May play a role in TLS during interstrand cross-link (ICL) repair. May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links., [UniProtKB, UniProtKB]; Identification as homolog to Mus308, [RefSeq, PubMed]; Inactivation of Poln in mouse embryonic fibroblasts did not alter cellular sensitivity to mitomycin C, cisplatin, or aldehydes. Pol nu-defective mice had no alteration in DNA end-joining during immunoglobulin class-switching. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0L3", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;2.7.7.7;4.2.99.-;2.7.7.102;3.6.4.13;5.6.2.-;4.2.99.18;2.3.2.27", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006302 double-strand break repair;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0019985 translesion synthesis;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TQ07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL95-1", "uniprot_id": "CF298_MOUSE", "mass": 33190.0, "length": 290, "protein_name": "Cilia- and flagella-associated protein 298", "gene_name": "Cfap298", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 298", "refseq_ac": "NP_080778", "gene_names_uniprotkb": "Cfap298", "gene_names_refseq": "1110004E09Rik; Cfap298", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 298; Protein kurly homolog", "protein_names_refseq": "UPF0769 protein C21orf59 homolog; cilia- and flagella-associated protein 298; protein kurly homolog", "tax_id": 10090, "disease": "primary ciliary dyskinesia 26 (Disease Ontology:DOID:0110627)", "pathway": " (mmu:68001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCL7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0036064 ciliary basal body;GO:0097228 sperm principal piece", "go_biological_process": "GO:0060271 cilium assembly;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BL95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BV13-1", "uniprot_id": "CSN7B_MOUSE", "mass": 29689.0, "length": 264, "protein_name": "COP9 signalosome complex subunit 7b", "gene_name": "Cops7b", "organism": "Mouse", "refseq_name": "COP9 signalosome complex subunit 7b isoform a", "refseq_ac": "NP_766562", "gene_names_uniprotkb": "Cops7b; Csn7b", "gene_names_refseq": "Cops7b; D1Wsu66e; E130114M23", "protein_names_uniprotkb": "COP9 signalosome complex subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 7b; COP9 complex S7b; COP9 signalosome complex subunit 7b isoform a; COP9 signalosome complex subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b", "tax_id": 10090, "disease": "", "pathway": " (mmu:26895); (R-MMU-5696394); (R-MMU-6781823); (R-MMU-8856825); (R-MMU-8951664)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "21750661;25428506;28528544;30779550;34428180;37507081;9707402", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88547;Q3TGG7;Q921G4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0010387 COP9 signalosome assembly;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BV13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35347-1", "uniprot_id": "DGCR6_MOUSE", "mass": 22837.0, "length": 198, "protein_name": "Protein DGCR6", "gene_name": "Dgcr6", "organism": "Mouse", "refseq_name": "protein DGCR6 isoform 1", "refseq_ac": "NP_001276742", "gene_names_uniprotkb": "Dgcr6", "gene_names_refseq": "Dgcr6", "protein_names_uniprotkb": "Protein DGCR6; DiGeorge syndrome critical region 6 homolog", "protein_names_refseq": "DiGeorge syndrome chromosome region 6; diGeorge syndrome critical region 6 homolog; protein DGCR6 isoform 1; protein DGCR6", "tax_id": 10090, "disease": "", "pathway": " (mmu:13353)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;9605865", "class_list": "", "function": "May have a role in early embryogenesis., [UniProtKB]; This gene encodes a protein that is similar to the gonadal protein in Drosophila (fruit fly). The encoded protein is thought to play a role in migration of neural crest cells during development. Deletions in the human gene are associated with DiGeorge syndrome (or velocardiofacial syndrome) which has many clinical features including cardiac abnormalities, cleft palate, atypical facial features, hypocalcemia, hypoparathyroidism and defective development or congenital absence of the thymus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D2P5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1D6-1", "uniprot_id": "CTHR1_MOUSE", "mass": 26460.0, "length": 245, "protein_name": "Collagen triple helix repeat-containing protein 1", "gene_name": "Cthrc1", "organism": "Mouse", "refseq_name": "collagen triple helix repeat-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_081054", "gene_names_uniprotkb": "Cthrc1", "gene_names_refseq": "1110014B07Rik; Cthrc1", "protein_names_uniprotkb": "Collagen triple helix repeat-containing protein 1", "protein_names_refseq": "collagen triple helix repeat-containing protein 1 isoform 1 precursor; collagen triple helix repeat-containing protein 1", "tax_id": 10090, "disease": "Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:68588)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16678498;18606138;21750661", "class_list": "", "function": "Cthrc1 expression overlaps considerably with those reported for TGF-beta family members and interstitial collagens., [RefSeq, PubMed]; Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex., [RefSeq, PubMed]; May act as a negative regulator of collagen matrix deposition., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAP6", "ec_number_list": "", "go_molecular_function": "GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0005109 frizzled binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0043005 neuron projection", "go_biological_process": "GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0033690 positive regulation of osteoblast proliferation;GO:0060071 Wnt signaling pathway, planar cell polarity pathway;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH19-1", "uniprot_id": "CS2IP_MOUSE", "mass": 79205.0, "length": 720, "protein_name": "Casein kinase II subunit alpha'-interacting protein", "gene_name": "Csnk2a2ip", "organism": "Mouse", "refseq_name": "casein kinase II subunit alpha'-interacting protein", "refseq_ac": "NP_001355650", "gene_names_uniprotkb": "Csnk2a2ip; Ckt2; Csnka2ip", "gene_names_refseq": "Ckt2; Csnk2a2ip; Csnka2ip", "protein_names_uniprotkb": "Casein kinase II subunit alpha'-interacting protein; CK2 target protein 2; Casein kinase 2 alpha prime interacting protein", "protein_names_refseq": "CK2 target protein 2; casein kinase II subunit alpha'-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:224291)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19273531;21750661", "class_list": "", "function": "May play a role in chromatin regulation of male germ cells., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B0GSC5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CH19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61488-1", "uniprot_id": "DHH_MOUSE", "mass": 43542.0, "length": 396, "protein_name": "Desert hedgehog protein", "gene_name": "Dhh", "organism": "Mouse", "refseq_name": "desert hedgehog protein preproprotein", "refseq_ac": "NP_031883", "gene_names_uniprotkb": "Dhh", "gene_names_refseq": "Dhh", "protein_names_uniprotkb": "Desert hedgehog protein; 3.1.-.-; DHH; HHG-3", "protein_names_refseq": "HHG-3; desert hedgehog protein preproprotein; desert hedgehog protein", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); 46,XY gonadal dysgenesis with minifascicular neuropathy (Disease Ontology:DOID:0051055); 46,XY sex reversal 7 (Disease Ontology:DOID:0111774); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448)", "pathway": " (mmu:13363); (R-MMU-5358346); (R-MMU-5362798); (R-MMU-5632681); (R-MMU-5635838)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10482238;11090455;21750661;32151560;33063110;34428180;40494346;7720571;7916661;8805249;9811851", "class_list": "", "function": "Precursor of desert hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:40494346). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, desert hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (DHH-N) (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, DHH-N acts as a morphogen, while the C-product is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB, PubMed]; The dually lipidated desert hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:40494346). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (PubMed:33063110, PubMed:40494346, PubMed:9811851). In the absence of DHH, patched represses the constitutive signaling activity of SMO (By similarity). DHH plays a key role in male gonad development (spermatogenesis) and the formation of Schwann cells (PubMed:10482238, PubMed:11090455, PubMed:8805249). Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (PubMed:11090455, PubMed:8805249). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (PubMed:10482238). May induce motor neurons in lateral neural tube and may have a polarizing activity (By similarity). Involved in tissue regeneration: secreted from epithelial neuroendocrine cells and elicits a regenerative response from mesenchymal cells (PubMed:40494346). Functions in cell-cell mediated juxtacrine signaling (By similarity). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (PubMed:32151560). Promotes endothelium integrity (PubMed:33063110)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.4.25.1;5.3.4.1;3.6.4.-;3.1.-.-;3.6.4.6;2.3.1.-;3.1.1.98;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0007267 cell-cell signaling;GO:0042552 myelination;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61488-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YW0-1", "uniprot_id": "CYH4_MOUSE", "mass": 45285.0, "length": 393, "protein_name": "Cytohesin-4", "gene_name": "Cyth4", "organism": "Mouse", "refseq_name": "cytohesin-4", "refseq_ac": "NP_082471", "gene_names_uniprotkb": "Cyth4; Pscd4", "gene_names_refseq": "2510004M07Rik; 5830469K17Rik; Cyth4; Pscd4; mFLJ00017", "protein_names_uniprotkb": "Cytohesin-4; PH, SEC7 and coiled-coil domain-containing protein 4", "protein_names_refseq": "PH, SEC7 and coiled-coil domain-containing protein 4; cytohesin-4; pleckstrin homology, Sec7 and coiled/coil domains 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72318); (R-MMU-6811438)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0045171 intercellular bridge;GO:0034451 centriolar satellite", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0M3-1", "uniprot_id": "CY1_MOUSE", "mass": 35328.0, "length": 325, "protein_name": "Cytochrome c1, heme protein, mitochondrial", "gene_name": "Cyc1", "organism": "Mouse", "refseq_name": "cytochrome c1, heme protein, mitochondrial", "refseq_ac": "NP_079843", "gene_names_uniprotkb": "Cyc1", "gene_names_refseq": "2610002H19Rik; Cyc1; Cyct1", "protein_names_uniprotkb": "Cytochrome c1, heme protein, mitochondrial; 7.1.1.8; Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Cytochrome c-1; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit", "protein_names_refseq": "complex III subunit 4; complex III subunit IV; cytochrome b-c1 complex subunit 4; cytochrome c1, heme protein, mitochondrial; ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 6 (Disease Ontology:DOID:0080115)", "pathway": " (mmu:66445); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "19026783;21750661;25428506;25605945;26495903;30084848;31219806;32973183;34428180;34616041;36288343;37453647;37507081;38575788", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDC5;Q3UAN2;Q63ZW4;Q9DCG0", "ec_number_list": "7.1.1.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity;GO:0009055 electron transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0016020 membrane", "go_biological_process": "GO:0033762 response to glucagon;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D0M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQA0-1", "uniprot_id": "CENPM_MOUSE", "mass": 20039.0, "length": 180, "protein_name": "Centromere protein M", "gene_name": "Cenpm", "organism": "Mouse", "refseq_name": "centromere protein M isoform 3", "refseq_ac": "NP_001073627", "gene_names_uniprotkb": "Cenpm; Pane1", "gene_names_refseq": "2610019I03Rik; Cenpm; Pane1", "protein_names_uniprotkb": "Centromere protein M; CENP-M; Proliferation-associated nuclear element protein 1", "protein_names_refseq": "CENP-M; centromere protein M isoform 3; proliferation associated nuclear element 1; proliferation-associated nuclear element protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66570); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "12881717;21750661;21952136;25428506;30779550;35820727", "class_list": "", "function": "A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity)., [UniProtKB]; This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THN3;Q91VS6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W50-1", "uniprot_id": "CSDE1_MOUSE", "mass": 88791.0, "length": 798, "protein_name": "Cold shock domain-containing protein E1", "gene_name": "Csde1", "organism": "Mouse", "refseq_name": "cold shock domain-containing protein E1 isoform 1", "refseq_ac": "NP_659150", "gene_names_uniprotkb": "Csde1; D3Jfr1", "gene_names_refseq": "Csde1; D3Jfr1; mKIAA0885; unr", "protein_names_uniprotkb": "Cold shock domain-containing protein E1", "protein_names_refseq": "NRAS-related; cold shock domain-containing protein E1 isoform 1; cold shock domain-containing protein E1; upstream of NRAS", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:229663)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;20173027;21750661;22645316;25153642;25428506;28135057;28315936;28528544;30084848;30779550;31219806;34428180;36724242;37828378;40684658", "class_list": "", "function": "Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells., [RefSeq, PubMed]; RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0035613 RNA stem-loop binding;GO:0140517 protein-RNA adaptor activity;GO:0106222 lncRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000932 P-body", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0075522 IRES-dependent viral translational initiation;GO:0045727 positive regulation of translation;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91W50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C166-1", "uniprot_id": "CPNE1_MOUSE", "mass": 58887.0, "length": 536, "protein_name": "Copine-1", "gene_name": "Cpne1", "organism": "Mouse", "refseq_name": "copine-1", "refseq_ac": "NP_733467", "gene_names_uniprotkb": "Cpne1", "gene_names_refseq": "1810028N16Rik; Cpne1; mKIAA4108", "protein_names_uniprotkb": "Copine-1; Copine I", "protein_names_refseq": "copine-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:266692); (R-MMU-1483206); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11471062;17114649;21750661;23806337;25428506;28528544;34428180;34767734;36525128;37454492;38062811", "class_list": "", "function": "CPNE1 mediates glycolysis and metastasis of breast cancer through activation of PI3K/AKT/HIF-1alpha signaling., [RefSeq, PubMed]; CPNE1 regulates myogenesis through the PERK-eIF2alpha pathway mediated by endoplasmic reticulum stress., [RefSeq, PubMed]; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Methylprednisolone Attenuates Lipopolysaccharide-Induced Sepsis by Modulating the Small Nucleolar RNA Host Gene 5/Copine 1 Pathway., [RefSeq, PubMed]; Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer., [RefSeq, PubMed]; This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q925K4;Q925K5", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0010629 negative regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6K9-1", "uniprot_id": "CERS5_MOUSE", "mass": 48167.0, "length": 414, "protein_name": "Ceramide synthase 5", "gene_name": "Cers5", "organism": "Mouse", "refseq_name": "ceramide synthase 5", "refseq_ac": "NP_082291", "gene_names_uniprotkb": "Cers5; Lass5; Trh4", "gene_names_refseq": "2310081H14Rik; Cers5; Lass5; Trh4", "protein_names_uniprotkb": "Ceramide synthase 5; 2.3.1.24; 2.3.1.291; CerS5; LAG1 longevity assurance homolog 5; Sphingoid base N-palmitoyltransferase CERS5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; Translocating chain-associating membrane protein homolog 4", "protein_names_refseq": "LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; TRAM homolog 4; ceramide synthase 5; sphingoid base N-palmitoyltransferase CERS5; sphingosine N-acyltransferase CERS5; translocating chain-associating membrane protein homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71949); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12912983;15772421;15823095;16100120;17609214;17977534;21750661;25428506;25605945;26853464;30084848;31150623;31219806;34428180;38961186;39182597", "class_list": "glycogene", "function": "Ceramide synthase that catalyzes the transfer of the fatty acyl chain from fatty acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:12912983, PubMed:15823095, PubMed:16100120, PubMed:17609214, PubMed:17977534, PubMed:26853464, PubMed:38961186). Can use different sphingoid bases as substrates for ceramide synthesis, such as sphinganine in de novo synthesis, and sphing-4E-enine (sphingosine), (4R)-hydroxysphinganine (phytosphingosine) or sphinga-4E,14Z-dienine in salvage pathways (By similarity) (PubMed:12912983, PubMed:15772421, PubMed:15823095, PubMed:17977534). Other fatty acyl-CoAs such as long-chain saturated stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA), myristoyl-CoA (tetradecanoyl-CoA; C14:0-CoA), and monounsaturated oleoyl-CoA (9Z-octadecenoyl-CoA; C18:1-CoA) can also act as acyl donors, but with less efficiency than hexadecanoyl-CoA (PubMed:15823095). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (PubMed:15772421)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LASS5 is the major ceramide synthase gene product involved in sphingolipid production that may also regulate phosphatidylcholine metabolism in pulmonary epithelia, [RefSeq, PubMed]; Lack of ceramide synthase 5 protects retinal ganglion cells from ocular hypertensive injury., [RefSeq, PubMed]; Lag1p family members trh1 and trh4 regulate (dihydro)ceramide synthases responsible for production of sphingolipids containing different fatty acids, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL17;Q80YB2;Q8BPH6;Q921T8;Q924Z3", "ec_number_list": "2.3.1.24;2.3.1.299;2.3.1.298;2.3.1.297;2.3.1.-;2.3.1.291", "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D6K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64735-1", "uniprot_id": "CR1L_MOUSE", "mass": 53763.0, "length": 483, "protein_name": "Complement component receptor 1-like protein", "gene_name": "Cr1l", "organism": "Mouse", "refseq_name": "complement component receptor 1-like protein isoform 1 precursor", "refseq_ac": "NP_038527", "gene_names_uniprotkb": "Cr1l; Crry; Cry", "gene_names_refseq": "Cr1l; Crry; Mcp; mCRY", "protein_names_uniprotkb": "Complement component receptor 1-like protein; Complement regulatory protein Crry; Protein p65", "protein_names_refseq": "complement component (3b/4b) receptor 1-like; complement component receptor 1-like protein isoform 1 precursor; complement component receptor 1-like protein; complement receptor related protein; complement regulatory protein Crry; protein p65", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365)", "pathway": " (mmu:12946); (R-MMU-6798695); (R-MMU-977606)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10642554;10779754;11986227;12767833;17242355;1730912;19144319;21183079;21750661;2307848;28348233;2911011;30217731;31219806;34428180;34709768;36450590;7528766;7691944", "class_list": "", "function": "Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; CRRY role in the retinal epithelium and photoreceptor degeneration, [RefSeq, PubMed]; Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction., [RefSeq, PubMed]; Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones., [RefSeq, PubMed]; Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QL18;Q3TV30;Q58E68;Q61447;Q61449;Q8CF59;Q8K328", "ec_number_list": "", "go_molecular_function": "GO:0001851 complement component C3b binding;GO:0001855 complement component C4b binding;GO:0001861 complement component C4b receptor activity;GO:0004877 complement component C3b receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0045087 innate immune response;GO:0071456 cellular response to hypoxia;GO:0007565 female pregnancy;GO:0045959 negative regulation of complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q64735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWQ4-1", "uniprot_id": "CMTR2_MOUSE", "mass": 87143.0, "length": 767, "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2", "gene_name": "Cmtr2", "organism": "Mouse", "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2", "refseq_ac": "NP_666327", "gene_names_uniprotkb": "Cmtr2; Ftsjd1", "gene_names_refseq": "C730036L12Rik; Cmtr2; Ftsjd1; MTr2", "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; 2.1.1.296; Cap methyltransferase 2; Cap2 2'O-ribose methyltransferase 2; FtsJ methyltransferase domain-containing protein 1; MTr2", "protein_names_refseq": "FtsJ methyltransferase domain containing 1; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; cap2 2'O-ribose methyltransferase 2; ftsJ methyltransferase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234728)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;31219806;34428180;39094818", "class_list": "", "function": "An essential role for Cmtr2 in mammalian embryonic development., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYT6;Q8R3E7", "ec_number_list": "2.1.1.296", "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0120550 methyltransferase cap2 activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BWQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2X8-1", "uniprot_id": "CH076_MOUSE", "mass": 41643.0, "length": 372, "protein_name": "Uncharacterized protein C8orf76 homolog", "gene_name": "9130401M01Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C8orf76 homolog", "refseq_ac": "NP_083694", "gene_names_uniprotkb": "9130401M01Rik", "gene_names_refseq": "9130401M01Rik", "protein_names_uniprotkb": "Uncharacterized protein C8orf76 homolog", "protein_names_refseq": "uncharacterized protein C8orf76 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75758)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20173027;21750661;25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHW3-1", "uniprot_id": "CCG6_MOUSE", "mass": 28145.0, "length": 260, "protein_name": "Voltage-dependent calcium channel gamma-6 subunit", "gene_name": "Cacng6", "organism": "Mouse", "refseq_name": "voltage-dependent calcium channel gamma-6 subunit", "refseq_ac": "NP_573446", "gene_names_uniprotkb": "Cacng6", "gene_names_refseq": "2310033H20Rik; Cacng6", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-6 subunit; Neuronal voltage-gated calcium channel gamma-6 subunit", "protein_names_refseq": "neuronal voltage-gated calcium channel gamma-6 subunit; voltage-dependent calcium channel gamma-6 subunit", "tax_id": 10090, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822)", "pathway": " (mmu:54378); (R-MMU-5576892); (R-MMU-5576893)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11738816;21127204;21750661;22534482", "class_list": "", "function": "Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonistrated that Cacng6 gene expression in mouse dorsal raphe nucleus, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:1990454 L-type voltage-gated calcium channel complex;GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB34-1", "uniprot_id": "CHM2A_MOUSE", "mass": 25134.0, "length": 222, "protein_name": "Charged multivesicular body protein 2a", "gene_name": "Chmp2a", "organism": "Mouse", "refseq_name": "charged multivesicular body protein 2a isoform a", "refseq_ac": "NP_081161", "gene_names_uniprotkb": "Chmp2a", "gene_names_refseq": "1500016L11Rik; Chmp2a; mVps2", "protein_names_uniprotkb": "Charged multivesicular body protein 2a; CHMP2a; Chromatin-modifying protein 2a; Vacuolar protein sorting-associated protein 2; mVps2", "protein_names_refseq": "charged multivesicular body protein 2a isoform a; chromatin modifying protein 2A; chromatin-modifying protein 2a; vacuolar protein sorting-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68953); (R-MMU-1632852); (R-MMU-432720); (R-MMU-5620971); (R-MMU-917729); (R-MMU-9668328)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15173323;16452087;21750661;34428180;34789720;38702144", "class_list": "", "function": "CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma model. Publication Status: Online-Only, [RefSeq, PubMed]; PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure. Publication Status: Online-Only, [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0031210 phosphatidylcholine binding;GO:0180020 membrane bending activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010324 membrane invagination;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DB34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQA6-1", "uniprot_id": "CHCH1_MOUSE", "mass": 13608.0, "length": 118, "protein_name": "Small ribosomal subunit protein mS37", "gene_name": "Chchd1", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS37", "refseq_ac": "NP_079642", "gene_names_uniprotkb": "Chchd1; Mrps37", "gene_names_refseq": "1110001O19Rik; 2400010G13Rik; Chchd1; MRP-S37", "protein_names_uniprotkb": "Small ribosomal subunit protein mS37; 28S ribosomal protein S37, mitochondrial; Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; MRP-S37", "protein_names_refseq": "28S ribosomal protein S37, mitochondrial; coiled-coil-helix-coiled-coil-helix domain-containing protein 1; small ribosomal subunit protein mS37", "tax_id": 10090, "disease": "", "pathway": " (mmu:66121); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q56A12", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVV7-1", "uniprot_id": "CEP95_MOUSE", "mass": 95210.0, "length": 827, "protein_name": "Centrosomal protein of 95 kDa", "gene_name": "Cep95", "organism": "Mouse", "refseq_name": "centrosomal protein of 95 kDa isoform 1", "refseq_ac": "NP_796062", "gene_names_uniprotkb": "Cep95; Ccdc45", "gene_names_refseq": "4732496G21Rik; AI118346; Ccdc45; Cep95; D330027A14Rik; F630025I20Rik", "protein_names_uniprotkb": "Centrosomal protein of 95 kDa; Cep95; Coiled-coil domain-containing protein 45", "protein_names_refseq": "centrosomal protein of 95 kDa isoform 1; centrosomal protein of 95 kDa; coiled-coil domain containing 45; coiled-coil domain-containing protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:320162)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5Z8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BVV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0M2-1", "uniprot_id": "CDCA7_MOUSE", "mass": 43837.0, "length": 382, "protein_name": "Cell division cycle-associated protein 7", "gene_name": "Cdca7", "organism": "Mouse", "refseq_name": "cell division cycle-associated protein 7 isoform a", "refseq_ac": "NP_080142", "gene_names_uniprotkb": "Cdca7", "gene_names_refseq": "2310021G01Rik; Cdca7; JPO1", "protein_names_uniprotkb": "Cell division cycle-associated protein 7", "protein_names_refseq": "c-Myc target JPO1; cell division cycle-associated protein 7 isoform a; cell division cycle-associated protein 7", "tax_id": 10090, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome 3 (Disease Ontology:DOID:0090010)", "pathway": " (mmu:66953)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;15994934;16580749;21183079;21750661;31226215;31970665;34428180;38335290", "class_list": "", "function": "CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses., [RefSeq, PubMed]; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity)., [UniProtKB, PubMed, UniProtKB]; The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation., [RefSeq, PubMed]; The results demonstrated that the C382Y and C407G mutations in mouse ZBTB24 abolish specific DNA binding and fail to induce Cdca7 expression, modeling the events in immunodeficiency-centromeric instability-facial anomalies syndrome in humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIS1;Q3U511;Q6NZE5;Q8C1A0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044729 hemi-methylated DNA-binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D0M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0E2-1", "uniprot_id": "CHRD_MOUSE", "mass": 101513.0, "length": 948, "protein_name": "Chordin", "gene_name": "Chrd", "organism": "Mouse", "refseq_name": "chordin isoform 2 precursor", "refseq_ac": "NP_001264970", "gene_names_uniprotkb": "Chrd", "gene_names_refseq": "Chd; Chrd", "protein_names_uniprotkb": "Chordin", "protein_names_refseq": "chordin isoform 2 precursor", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (mmu:12667)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11260715;15381701;21750661;32105677;9782094", "class_list": "", "function": "Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes., [UniProtKB]; Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0045545 syndecan binding;GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0098793 presynapse", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0000578 embryonic axis specification;GO:0021513 spinal cord dorsal/ventral patterning;GO:0014029 neural crest formation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z0E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1K9-1", "uniprot_id": "CETN2_MOUSE", "mass": 19797.0, "length": 172, "protein_name": "Centrin-2", "gene_name": "Cetn2", "organism": "Mouse", "refseq_name": "centrin-2", "refseq_ac": "NP_062278", "gene_names_uniprotkb": "Cetn2; Calt", "gene_names_refseq": "1110034A02Rik; Calt; Cetn2; caltractin", "protein_names_uniprotkb": "Centrin-2; Caltractin isoform 1", "protein_names_refseq": "caltractin, 20 kDa calcium binding protein; centrin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26370); (R-MMU-2565942); (R-MMU-3108214); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-8854518)", "pathway_count": 11, "publication_count": 5, "publication_id_list": "10854409;11250075;21183079;21750661;30647131", "class_list": "", "function": "As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores., [UniProtKB, UniProtKB]; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Rad23b appears to stabilize Xpc. In vitro, stimulates DNA binding of the Xpc:Rad23b dimer (By similarity)., [UniProtKB]; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity)., [UniProtKB]; Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22)., [RefSeq, PubMed]; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUQ6;B1AUQ8;Q3UBB4;Q9CWM0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0032795 heterotrimeric G-protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005929 cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0015031 protein transport;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R1K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1K4-1", "uniprot_id": "CENPI_MOUSE", "mass": 85403.0, "length": 746, "protein_name": "Centromere protein I", "gene_name": "Cenpi", "organism": "Mouse", "refseq_name": "centromere protein I", "refseq_ac": "NP_001292560", "gene_names_uniprotkb": "Cenpi; Fshprh1", "gene_names_refseq": "CENP-I; Cenpi; Fshprh1", "protein_names_uniprotkb": "Centromere protein I; CENP-I; FSH primary response protein 1; Follicle-stimulating hormone primary response protein", "protein_names_refseq": "FSH primary response protein 1; centromere protein I; follicle-stimulating hormone primary response protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:102920); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "21750661;34203471;34428180", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity)., [UniProtKB]; This gene encodes a protein that may be constitutively associated with centromeres and might be involved in recruiting centromere protein A to the centromere for kinetochore assembly. A similar gene in human is involved in the response of gonadal tissues to follicle-stimulating hormone. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXU9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0034080 CENP-A containing chromatin assembly;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LU8-1", "uniprot_id": "CF062_MOUSE", "mass": 27083.0, "length": 229, "protein_name": "Uncharacterized protein C6orf62 homolog", "gene_name": "BC005537", "organism": "Mouse", "refseq_name": "uncharacterized protein C6orf62 homolog", "refseq_ac": "NP_077793", "gene_names_uniprotkb": "BC005537", "gene_names_refseq": "8030460C05Rik; BC005537", "protein_names_uniprotkb": "Uncharacterized protein C6orf62 homolog", "protein_names_refseq": "uncharacterized protein C6orf62 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:79555)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99LU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XA9-1", "uniprot_id": "CHIA_MOUSE", "mass": 52003.0, "length": 473, "protein_name": "Acidic mammalian chitinase", "gene_name": "Chia1; Chia", "organism": "Mouse", "refseq_name": "acidic mammalian chitinase precursor", "refseq_ac": "NP_075675", "gene_names_uniprotkb": "Chia1; Chia; Chia1; Chia", "gene_names_refseq": "2200003E03Rik; AMCase; Chia1; Chia; YNL", "protein_names_uniprotkb": "Acidic mammalian chitinase; 3.2.1.14; AMCase; YNL", "protein_names_refseq": "acidic chitinase; acidic mammalian chitinase precursor; acidic mammalian chitinase", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); silicosis (Disease Ontology:DOID:10325); cryptococcosis (Disease Ontology:DOID:12053); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); neuromyelitis optica (Disease Ontology:DOID:8869)", "pathway": " (mmu:81600); (R-MMU-189085)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11085997;12133911;12971947;15192232;16556727;18294964;18824549;19076793;21750661;38884443", "class_list": "glycogene;glycosylhydrolase", "function": "AMCase provides the first positive molecular marker of distal Clara cell secretory protein-expressing cells under these conditions., [RefSeq, PubMed]; Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Findings show that acidic mammalian chitinase is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13)-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model, [RefSeq, PubMed]; Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0T468;B8K282;Q3TVE7;Q99PH2;Q9D803;Q9JLN1", "ec_number_list": "3.2.1.14", "go_molecular_function": "GO:0004568 chitinase activity;GO:0008843 endochitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0032722 positive regulation of chemokine production;GO:0000272 polysaccharide catabolic process;GO:0002532 production of molecular mediator involved in inflammatory response;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91XA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCC3-1", "uniprot_id": "CL056_MOUSE", "mass": 59886.0, "length": 530, "protein_name": "Uncharacterized protein C12orf56 homolog", "gene_name": "D930020B18Rik", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "D930020B18Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein C12orf56 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:216393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CCC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3A2-1", "uniprot_id": "CDPF1_MOUSE", "mass": 13300.0, "length": 119, "protein_name": "Cysteine-rich DPF motif domain-containing protein 1", "gene_name": "Cdpf1", "organism": "Mouse", "refseq_name": "cysteine-rich DPF motif domain-containing protein 1", "refseq_ac": "NP_001158097", "gene_names_uniprotkb": "Cdpf1; 2210021J22Rik", "gene_names_refseq": "2210021J22Rik; Cdpf1", "protein_names_uniprotkb": "Cysteine-rich DPF motif domain-containing protein 1", "protein_names_refseq": "UPF0595 protein C22orf40 homolog; cysteine-rich DPF motif domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72355)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PUA4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R3A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2R6-1", "uniprot_id": "COA3_MOUSE", "mass": 11987.0, "length": 108, "protein_name": "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial", "gene_name": "Coa3", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor 3 homolog, mitochondrial", "refseq_ac": "NP_080894", "gene_names_uniprotkb": "Coa3; Ccdc56", "gene_names_refseq": "1810033A19Rik; Ccdc56; Coa3; D11Ertd99e; HSPC009", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Coiled-coil domain-containing protein 56", "protein_names_refseq": "coiled-coil domain containing 56; coiled-coil domain-containing protein 56; cytochrome c oxidase assembly factor 3 homolog, mitochondrial; cytochrome c oxidase assembly protein 3 homolog, mitochondrial", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 14 (Disease Ontology:DOID:0070499)", "pathway": " (mmu:52469); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16625196;21750661;31219806;34428180;36288343;37507081", "class_list": "", "function": "Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for assembly of cytochrome c oxidase (complex IV)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4J6", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D2R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZX2-1", "uniprot_id": "CEP89_MOUSE", "mass": 90320.0, "length": 791, "protein_name": "Centrosomal protein of 89 kDa", "gene_name": "Cep89", "organism": "Mouse", "refseq_name": "centrosomal protein of 89 kDa", "refseq_ac": "NP_082396", "gene_names_uniprotkb": "Cep89; Ccdc123", "gene_names_refseq": "2610507L03Rik; Ccdc123; Cep89", "protein_names_uniprotkb": "Centrosomal protein of 89 kDa; Cep89; Coiled-coil domain-containing protein 123", "protein_names_refseq": "centrosomal protein of 89 kDa; coiled-coil domain containing 123; coiled-coil domain-containing protein 123, mitochondrial", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (mmu:72140); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19144319;21750661;34428180;35820727", "class_list": "", "function": "Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C127", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005758 mitochondrial intermembrane space;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0060271 cilium assembly;GO:0007005 mitochondrion organization;GO:1905515 non-motile cilium assembly;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CZX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUT7-1", "uniprot_id": "CCR9_MOUSE", "mass": 41913.0, "length": 369, "protein_name": "C-C chemokine receptor type 9", "gene_name": "Ccr9", "organism": "Mouse", "refseq_name": "C-C chemokine receptor type 9", "refseq_ac": "NP_001160097", "gene_names_uniprotkb": "Ccr9; Cmkbr10", "gene_names_refseq": "A130091K22Rik; Ccr9; Cmkbr10; GPR-9-6", "protein_names_uniprotkb": "C-C chemokine receptor type 9; C-C CKR-9; CC-CKR-9; CCR-9; Chemokine C-C receptor 10", "protein_names_refseq": "C-C CKR-9; C-C chemokine receptor type 9; CC-CKR-9; CCR-9; chemokine (C-C motif) receptor 9; chemokine C-C receptor 10", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:12769); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10229797;10602049;11751956;21750661;35943802;37620389;39337509", "class_list": "", "function": "CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury. Publication Status: Online-Only, [RefSeq, PubMed]; Characterization of CCR9 expression during T cell development, [RefSeq, PubMed]; Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4[+] T-Cells to Infiltrate the Colonic Mucosa. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of chemokine receptor 9 facilitates CD4[+]CD8alphaalpha[+] intraepithelial lymphocyte development. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level., [UniProtKB]; This gene is a mouse CCR9. See also GenBank files AJ132336 and AJ131357., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RSM5;Q543I4", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WUT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2I2-1", "uniprot_id": "CCHCR_MOUSE", "mass": 87105.0, "length": 770, "protein_name": "Coiled-coil alpha-helical rod protein 1", "gene_name": "Cchcr1", "organism": "Mouse", "refseq_name": "coiled-coil alpha-helical rod protein 1 isoform 2", "refseq_ac": "NP_666360", "gene_names_uniprotkb": "Cchcr1; Hcr", "gene_names_refseq": "Cchcr1; Hcr", "protein_names_uniprotkb": "Coiled-coil alpha-helical rod protein 1; Alpha-helical coiled-coil rod protein", "protein_names_refseq": "HCR (a-helix coiled-coil rod homolog); alpha-helical coiled-coil rod protein; coiled-coil alpha-helical rod protein 1 isoform 2", "tax_id": 10090, "disease": "alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:240084)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;32580135", "class_list": "", "function": "Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss., [RefSeq, PubMed]; May be a regulator of keratinocyte proliferation or differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UWG0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0030154 cell differentiation;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTW8-1", "uniprot_id": "CK5P1_MOUSE", "mass": 66110.0, "length": 588, "protein_name": "Mitochondrial tRNA methylthiotransferase CDK5RAP1", "gene_name": "Cdk5rap1", "organism": "Mouse", "refseq_name": "mitochondrial tRNA methylthiotransferase CDK5RAP1", "refseq_ac": "NP_080152", "gene_names_uniprotkb": "Cdk5rap1", "gene_names_refseq": "2310066P17Rik; Cdk5rap1", "protein_names_uniprotkb": "Mitochondrial tRNA methylthiotransferase CDK5RAP1; 2.8.4.3; CDK5 activator-binding protein C42; CDK5 regulatory subunit-associated protein 1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase", "protein_names_refseq": "CDK5 activator-binding protein C42; mitochondrial tRNA methylthiotransferase CDK5RAP1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66971)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25738458;34001214;37258461", "class_list": "", "function": "Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:25738458). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:25738458). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (PubMed:25738458)., [UniProtKB, UniProtKB, PubMed]; Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6Q4", "ec_number_list": "2.8.4.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0044877 protein-containing complex binding;GO:0035597 tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0009451 RNA modification;GO:0070131 positive regulation of mitochondrial translation;GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVC4-1", "uniprot_id": "CCD68_MOUSE", "mass": 37992.0, "length": 333, "protein_name": "Coiled-coil domain-containing protein 68", "gene_name": "Ccdc68", "organism": "Mouse", "refseq_name": "coiled-coil domain-containing protein 68", "refseq_ac": "NP_958750", "gene_names_uniprotkb": "Ccdc68", "gene_names_refseq": "Ccdc68", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 68", "protein_names_refseq": "coiled-coil domain-containing protein 68", "tax_id": 10090, "disease": "", "pathway": " (mmu:381175)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28422092", "class_list": "", "function": "Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VD6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0034454 microtubule anchoring at centrosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYH8-1", "uniprot_id": "CHD9_MOUSE", "mass": 323860.0, "length": 2885, "protein_name": "ATP-dependent chromatin remodeler CHD9", "gene_name": "Chd9", "organism": "Mouse", "refseq_name": "ATP-dependent chromatin remodeler CHD9 isoform 1", "refseq_ac": "NP_001297459", "gene_names_uniprotkb": "Chd9; Kiaa0308; Pric320", "gene_names_refseq": "1810014J18Rik; 9030205D12Rik; A330063D19Rik; AD013; Chd9; PRIC320; mKIAA0308", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD9; 3.6.4.-; CHD-9; Chromo domain-containing protein 9; PPAR-alpha-interacting complex protein 320 kDa; Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD9 isoform 1; ATP-dependent chromatin remodeler CHD9; ATP-dependent helicase CHD9; PPAR-alpha-interacting complex protein 320 kDa; chromo domain-containing protein 9; ciprofibrate-bound protein PRIC320; peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein", "tax_id": 10090, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:109151); (R-MMU-400206); (R-MMU-9707564)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16419031;16523501;16554032;21750661;29665362;30059200;31219806;32453735;34428180;35820727;36210013", "class_list": "", "function": "A loosened chromatin structure, which is mediated by Chd9, is a prerequisite for the acquisition of totipotency after fertilization., [RefSeq, PubMed]; CReMM is a chromodomain helicase-DNA-binding protein expressed by osteoprogenitors[CReMM], [RefSeq, PubMed]; Gene expression regulation by the Chromodomain helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development. Publication Status: Online-Only, [RefSeq, PubMed]; Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA (By similarity). Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis., [UniProtKB]; Results imply that in osteogenic cells CReMM/CHD9 selectively interacts with promoters activated in the tissue at the appropriate time of embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMV5;Q8BJG8;Q8BZJ2;Q8CHG8", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.5.1.-;3.5.1.98;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.3.1.48;2.3.1.-;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;2.1.1.-;2.1.1.319", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BYH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZJ8-1", "uniprot_id": "CH034_MOUSE", "mass": 51086.0, "length": 459, "protein_name": "Uncharacterized protein C8orf34 homolog", "gene_name": "A830018L16Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C8orf34 homolog isoform 1", "refseq_ac": "NP_001153841", "gene_names_uniprotkb": "A830018L16Rik", "gene_names_refseq": "A830018L16Rik", "protein_names_uniprotkb": "Uncharacterized protein C8orf34 homolog", "protein_names_refseq": "uncharacterized protein C8orf34 homolog isoform 1; uncharacterized protein C8orf34 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:320492)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVZ9;Q8BJN6;Q8BUZ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0C4-1", "uniprot_id": "CCSE1_MOUSE", "mass": 98217.0, "length": 895, "protein_name": "Serine-rich coiled-coil domain-containing protein 1", "gene_name": "Ccser1", "organism": "Mouse", "refseq_name": "serine-rich coiled-coil domain-containing protein 1", "refseq_ac": "NP_001157788", "gene_names_uniprotkb": "Ccser1; Fam190a; Kiaa1680", "gene_names_refseq": "6230405M12Rik; C130092O11Rik; Ccser1; Fam190a", "protein_names_uniprotkb": "Serine-rich coiled-coil domain-containing protein 1; Coiled-coil serine-rich protein 1", "protein_names_refseq": "coiled-coil serine-rich protein 1; family with sequence similarity 190, member A; protein FAM190A; serine-rich coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:232035)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;37653038", "class_list": "", "function": "CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90beta complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KN97;Q69ZD5;Q8C822", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0072376 protein activation cascade;GO:0050821 protein stabilization;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB62-1", "uniprot_id": "CNTRB_MOUSE", "mass": 99404.0, "length": 887, "protein_name": "Centrobin", "gene_name": "Cntrob", "organism": "Mouse", "refseq_name": "centrobin", "refseq_ac": "NP_766148", "gene_names_uniprotkb": "Cntrob; Lip8", "gene_names_refseq": "9830165K03Rik; Cntrob; Lip8; Nip2", "protein_names_uniprotkb": "Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8", "protein_names_refseq": "LYST-interacting protein 8; centrobin; centrosomal BRCA2-interacting protein", "tax_id": 10090, "disease": "male infertility due to acephalic spermatozoa (Disease Ontology:DOID:0112311)", "pathway": " (mmu:216846)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19117032;19533028;20569513;21750661;26083938;34428180", "class_list": "", "function": "Centrobin may be a possible substrate of Nek2 responsible for the meiotic spindle assembly in the mouse oocytes., [RefSeq, PubMed]; Cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle, [RefSeq, PubMed]; Data show that a residual amount of centrobin was detected at the centrosomes of the resting cells, suggesting its role for maintaining integrity of the centrosome, especially of the daughter centriole in the cells., [RefSeq, PubMed]; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis (By similarity)., [UniProtKB]; The phenotypic similarities of the Nip2/centrobin- and Nek2-suppressed embryos suggest that Nip2/centrobin may be a substrate of Nek2 that is required for mitotic spindle assembly in early mouse embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0QZN4;Q5NCF3", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902017 regulation of cilium assembly;GO:0007099 centriole replication;GO:0051299 centrosome separation;GO:1902410 mitotic cytokinetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CB62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIN6-1", "uniprot_id": "CELF3_MOUSE", "mass": 50520.0, "length": 465, "protein_name": "CUGBP Elav-like family member 3", "gene_name": "Celf3", "organism": "Mouse", "refseq_name": "CUGBP Elav-like family member 3 isoform 1", "refseq_ac": "NP_001276542", "gene_names_uniprotkb": "Celf3; Tnrc4", "gene_names_refseq": "4930415M08Rik; BRUNOL1; CAGH4; Celf3; ERDA4; ETR-1; Tnrc4", "protein_names_uniprotkb": "CUGBP Elav-like family member 3; Bruno-like protein 1; CELF-3; CUG-BP- and ETR-3-like factor 3; ELAV-type RNA-binding protein 1; ETR-1; RNA-binding protein BRUNOL-1; Trinucleotide repeat-containing gene 4 protein", "protein_names_refseq": "CUG-BP- and ETR-3-like factor 3; CUGBP Elav-like family member 3 isoform 1; ELAV-type RNA-binding protein 1; RNA-binding protein BRUNOL-1; VCUGBP, Elav-like family member 3; bruno-like protein 1; trinucleotide repeat containing 4; trinucleotide repeat-containing gene 4 protein", "tax_id": 10090, "disease": "myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (mmu:78784)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17393433;21750661", "class_list": "", "function": "Brunol1 might be nonessential protein for mouse embryonic development and spermatogenesis., [RefSeq, PubMed]; RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFH2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0097322 7SK snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0008380 RNA splicing;GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CIN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K015-1", "uniprot_id": "CENPO_MOUSE", "mass": 34154.0, "length": 298, "protein_name": "Centromere protein O", "gene_name": "Cenpo", "organism": "Mouse", "refseq_name": "centromere protein O isoform 1", "refseq_ac": "NP_598807", "gene_names_uniprotkb": "Cenpo; Mcm21r", "gene_names_refseq": "2810429O05Rik; 8430427C03Rik; Cenpo; D12Ertd482e", "protein_names_uniprotkb": "Centromere protein O; CENP-O", "protein_names_refseq": "centromere protein O isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52504); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "19224205;20173027;21750661;25428506;25605945;27802388;30084848;30779550;31219806;34428180", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R587;Q9CYY6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0031511 Mis6-Sim4 complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K015-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2Q5-1", "uniprot_id": "CHCH7_MOUSE", "mass": 10102.0, "length": 85, "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "gene_name": "Chchd7", "organism": "Mouse", "refseq_name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "refseq_ac": "NP_001177251", "gene_names_uniprotkb": "Chchd7", "gene_names_refseq": "1810049H20Rik; Chchd7", "protein_names_uniprotkb": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGP4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDS7-3", "uniprot_id": "CE57L_MOUSE", "mass": 46790.0, "length": 400, "protein_name": "Centrosomal protein CEP57L1", "gene_name": "Cep57l1", "organism": "Mouse", "refseq_name": "centrosomal protein CEP57L1 isoform 3", "refseq_ac": "NP_001230003", "gene_names_uniprotkb": "Cep57l1; Cep57r", "gene_names_refseq": "2410017P07Rik; 4930484D11Rik; Cep57l1; cep57R", "protein_names_uniprotkb": "Centrosomal protein CEP57L1; Centrosomal protein 57kDa-like protein 1; Centrosomal protein of 57 kDa-related protein; Cep57-related protein; Cep57R", "protein_names_refseq": "centrosomal protein 57kDa-like protein 1; centrosomal protein CEP57L1 isoform 3; centrosomal protein CEP57L1; centrosomal protein of 57 kDa-related protein; cep57-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:103268)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "Centrosomal protein which may be required for microtubule attachment to centrosomes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZE0;Q9D5A1", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDS7-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE95-1", "uniprot_id": "CH082_MOUSE", "mass": 24330.0, "length": 218, "protein_name": "UPF0598 protein C8orf82 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "UPF0598 protein C8orf82 homolog isoform 1", "refseq_ac": "NP_663447", "gene_names_uniprotkb": "", "gene_names_refseq": "1110033I13Rik; C030006K11Rik", "protein_names_uniprotkb": "UPF0598 protein C8orf82 homolog", "protein_names_refseq": "UPF0598 protein C8orf82 homolog isoform 1; UPF0598 protein C8orf82 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:223665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK86", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VE95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V57-1", "uniprot_id": "CHIN_MOUSE", "mass": 53193.0, "length": 459, "protein_name": "N-chimaerin", "gene_name": "Chn1", "organism": "Mouse", "refseq_name": "N-chimaerin isoform 3", "refseq_ac": "NP_001106717", "gene_names_uniprotkb": "Chn1; Arhgap2", "gene_names_refseq": "0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik; ARHGAP2; Chn1", "protein_names_uniprotkb": "N-chimaerin; A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2", "protein_names_refseq": "A-chimaerin; N-chimaerin isoform 3; N-chimaerin; N-chimerin; NC; alpha-chimerin; alpha1 chimaerin; alpha2 chimaerin; alpha3-chimerin; chimerin (chimaerin) 1; rho GTPase-activating protein 2", "tax_id": 10090, "disease": "Duane retraction syndrome 2 (Disease Ontology:DOID:0061028); Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (mmu:108699); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11471062;15447672;16446429;17719550;17785183;21750661;31757963", "class_list": "", "function": "Chimaerin, one of the Rho GTPase activating proteins, is transcriptionally up-regulated after exposure to neurotrophins in post-natal cerebellar neurons., [RefSeq, PubMed]; GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms (By similarity). Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance., [UniProtKB, PubMed]; Lpha1-chimaerin is an activity-regulated Rho GTPase regulator that is activated by phospholipase Cbeta-coupled cell surface receptors and contributes to pruning of dendritic arbors, [RefSeq, PubMed]; Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of Efnb3 forward signaling, [RefSeq, PubMed]; Rac1 activation and expression of alpha2-chimaerin are stimulated by single-trial contextual fear conditioning. The balance between activated Rac1 and expressed alpha2-chimaerin defines dynamic long-term memory maintenance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATM0;Q3UGY3;Q7TQE5;Q8BWU6;Q9D9B3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046875 ephrin receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91V57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WU0-1", "uniprot_id": "EST1F_MOUSE", "mass": 61612.0, "length": 561, "protein_name": "Carboxylesterase 1F", "gene_name": "Ces1f", "organism": "Mouse", "refseq_name": "carboxylesterase 1F precursor", "refseq_ac": "NP_659179", "gene_names_uniprotkb": "Ces1f; CesML1", "gene_names_refseq": "Ces1f; CesML1; TGH-2", "protein_names_uniprotkb": "Carboxylesterase 1F; 3.1.1.1; Carboxylic ester hydrolase; TGH-2; Triacylglycerol hydrolase 2", "protein_names_refseq": "carboxylesterase 1F precursor; carboxylic ester hydrolase; liver carboxylesterase B-1; triacylglycerol hydrolase 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:234564)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16804080;34428180;37400381;37453647", "class_list": "glycogene", "function": "Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters (By similarity). Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis., [UniProtKB, PubMed, UniProtKB]; [Effects of in vivo targeted carboxylesterase 1f gene knockdown on the Kupffer cells polarization activity in mice with acute liver failure]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6RHA4;Q3UWB1", "ec_number_list": "3.1.1.1;3.1.1.-;3.1.1.23;3.1.1.79;3.1.1.3;3.1.1.88;3.1.1.13;3.1.1.67;3.1.1.28", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0030855 epithelial cell differentiation;GO:0071397 cellular response to cholesterol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91WU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z98-1", "uniprot_id": "CHIL4_MOUSE", "mass": 44975.0, "length": 402, "protein_name": "Chitinase-like protein 4", "gene_name": "Chil4", "organism": "Mouse", "refseq_name": "chitinase-like protein 4 precursor", "refseq_ac": "NP_660108", "gene_names_uniprotkb": "Chil4; Chi3l4; Ym2", "gene_names_refseq": "Chi3l4; Chil4; Ym2", "protein_names_uniprotkb": "Chitinase-like protein 4; Chitinase-3-like protein 4; Secreted protein Ym2", "protein_names_refseq": "chitinase 3-like 4, Chil4; chitinase-3-like protein 4; chitinase-like protein 4 precursor; chitinase-like protein 4; secreted protein Ym2", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); neuromyelitis optica (Disease Ontology:DOID:8869)", "pathway": " (mmu:104183)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11141507;11553626;15148607;16174095;30084848;34016714;9828134", "class_list": "glycogene;glycosylhydrolase", "function": "Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation., [RefSeq, PubMed]; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity., [UniProtKB, PubMed]; Induced only in the presence of IL-4., [RefSeq, PubMed]; The eosinophilic protein Ym2 (chitinase 3-like 4) was isolated from characteristic hyaline gastric lesion mainly found in female CYP1A2-null mice. The relation between Ym2 and CYP1A2 is unknown., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 89, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2C9;Q8VH43;Q8VHG1", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding;GO:0004568 chitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0032722 positive regulation of chemokine production;GO:0002532 production of molecular mediator involved in inflammatory response;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91Z98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Q9-1", "uniprot_id": "CHID1_MOUSE", "mass": 44906.0, "length": 393, "protein_name": "Chitinase domain-containing protein 1", "gene_name": "Chid1", "organism": "Mouse", "refseq_name": "chitinase domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_001136153", "gene_names_uniprotkb": "Chid1", "gene_names_refseq": "3110023E09Rik; Chid1", "protein_names_uniprotkb": "Chitinase domain-containing protein 1", "protein_names_refseq": "chitinase domain-containing protein 1 isoform 1 precursor; chitinase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68038); (R-MMU-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "glycogene", "function": "Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVF7;Q6P8U4;Q8C7C5;Q9CXR7", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0012505 endomembrane system;GO:0005770 late endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045087 innate immune response;GO:0005975 carbohydrate metabolic process;GO:1900016 negative regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q922Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925P2-1", "uniprot_id": "CEAM2_MOUSE", "mass": 57202.0, "length": 520, "protein_name": "Cell adhesion molecule CEACAM2", "gene_name": "Ceacam2", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM2 isoform a precursor", "refseq_ac": "NP_001106839", "gene_names_uniprotkb": "Ceacam2; Bgp2", "gene_names_refseq": "Bgp2; Ceacam2-L; Ceacam2", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM2; BGP-2; Biliary glycoprotein 2; CEA-related cell adhesion molecule 2; Carcinoembryonic antigen-related cell adhesion molecule 2", "protein_names_refseq": "BGP-2; CEA-related cell adhesion molecule 2; biliary glycoprotein 2; carcinoembryonic antigen-related cell adhesion molecule 2- Long; cell adhesion molecule CEACAM2 isoform a precursor; cell adhesion molecule CEACAM2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26367); (R-MMU-163125); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10491101;11284729;19349973;20381490;20410265;22159884;23070997;24948196;25085348;26586918;27161904;34428180;8207827;9696818", "class_list": "", "function": "CEACAM2 regulates insulin secretion, at least in part, by a GLP-1-mediated mechanism, independent of confounding metabolic factors., [RefSeq, PubMed]; Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus., [UniProtKB]; Disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2 is essential to maintain a normal integrin alphaIIbbeta3-mediated platelet function., [RefSeq, PubMed]; Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling, [RefSeq, PubMed]; Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium., [UniProtKB]; Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR-CEACAM2-L interaction in mouse testis, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "D0VY57;E9QLI9;I7HDK2;Q61349;Q8R1N5", "ec_number_list": "", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:2000252 negative regulation of feeding behavior;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q925P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KU6-1", "uniprot_id": "CF089_MOUSE", "mass": 39486.0, "length": 348, "protein_name": "Bombesin receptor-activated protein C6orf89 homolog", "gene_name": "BC004004", "organism": "Mouse", "refseq_name": "bombesin receptor-activated protein C6orf89 homolog isoform 1", "refseq_ac": "NP_085038", "gene_names_uniprotkb": "BC004004", "gene_names_refseq": "2400006G15Rik; BC004004", "protein_names_uniprotkb": "Bombesin receptor-activated protein C6orf89 homolog", "protein_names_refseq": "bombesin receptor-activated protein C6orf89 homolog isoform 1; bombesin receptor-activated protein C6orf89 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:80748)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20173027;21750661;25428506;25605945;27802388;30084848;33649389;34428180;36520154", "class_list": "", "function": "Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells., [UniProtKB, UniProtKB]; Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDQ4;Q7TSE2;Q7TSE4;Q8BST4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045787 positive regulation of cell cycle;GO:0042060 wound healing;GO:0050673 epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99KU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPQ5-1", "uniprot_id": "CENPQ_MOUSE", "mass": 30501.0, "length": 267, "protein_name": "Centromere protein Q", "gene_name": "Cenpq", "organism": "Mouse", "refseq_name": "centromere protein Q", "refseq_ac": "NP_114069", "gene_names_uniprotkb": "Cenpq", "gene_names_refseq": "2610528M18Rik; Cenpq", "protein_names_uniprotkb": "Centromere protein Q; CENP-Q", "protein_names_refseq": "CENP-Q; centromere protein Q", "tax_id": 10090, "disease": "", "pathway": " (mmu:83815); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "21750661;22299025", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2G4;Q8VEF8;Q9CX70", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:1905342 positive regulation of protein localization to kinetochore;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQA8-1", "uniprot_id": "CEP19_MOUSE", "mass": 19170.0, "length": 163, "protein_name": "Centrosomal protein of 19 kDa", "gene_name": "Cep19", "organism": "Mouse", "refseq_name": "centrosomal protein of 19 kDa", "refseq_ac": "NP_080168", "gene_names_uniprotkb": "Cep19", "gene_names_refseq": "1500031L02Rik; Cep19", "protein_names_uniprotkb": "Centrosomal protein of 19 kDa; Cep19", "protein_names_refseq": "centrosomal protein of 19 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:66994)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24268657", "class_list": "", "function": "Loss of the ciliary protein CEP19 in humans and mice causes morbid obesity., [RefSeq, PubMed]; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0034454 microtubule anchoring at centrosome;GO:0097712 vesicle targeting, trans-Golgi to periciliary membrane compartment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQC3-1", "uniprot_id": "CFA95_MOUSE", "mass": 26594.0, "length": 228, "protein_name": "Cilia- and flagella-associated protein 95", "gene_name": "Cfap95", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 95", "refseq_ac": "NP_080464", "gene_names_uniprotkb": "Cfap95", "gene_names_refseq": "1700028P14Rik; Cfap95", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 95", "protein_names_refseq": "cilia- and flagella-associated protein 95; protein CFAP95; uncharacterized protein C9orf135 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67483)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;28345668;37295417;37865089;37989994", "class_list": "", "function": "1700028P14Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQE8-1", "uniprot_id": "RTRAF_MOUSE", "mass": 28152.0, "length": 244, "protein_name": "tRNA-splicing ligase complex subunit RTRAF", "gene_name": "RTRAF", "organism": "Mouse", "refseq_name": "tRNA-splicing ligase complex subunit RTRAF", "refseq_ac": "NP_080804", "gene_names_uniprotkb": "RTRAF", "gene_names_refseq": "2700060E02Rik; Rtraf", "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit RTRAF; RNA transcription, translation and transport factor protein", "protein_names_refseq": "RNA transcription, translation and transport factor protein; UPF0568 protein C14orf166 homolog; tRNA-splicing ligase complex subunit RTRAF", "tax_id": 10090, "disease": "", "pathway": " (mmu:68045)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29187734;31219806;34428180", "class_list": "", "function": "Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Could also play a role in RNA transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQP3-1", "uniprot_id": "CHCH5_MOUSE", "mass": 12326.0, "length": 110, "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5", "gene_name": "Chchd5", "organism": "Mouse", "refseq_name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 5", "refseq_ac": "NP_079671", "gene_names_uniprotkb": "Chchd5", "gene_names_refseq": "1110027L01Rik; Chchd5", "protein_names_uniprotkb": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66170)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWM2-1", "uniprot_id": "CDCA4_MOUSE", "mass": 26107.0, "length": 237, "protein_name": "Cell division cycle-associated protein 4", "gene_name": "Cdca4", "organism": "Mouse", "refseq_name": "cell division cycle-associated protein 4", "refseq_ac": "NP_082299", "gene_names_uniprotkb": "Cdca4; Hepp", "gene_names_refseq": "2410018C03Rik; Cdca4; HEPP; SEI-3", "protein_names_uniprotkb": "Cell division cycle-associated protein 4; Hematopoietic progenitor protein", "protein_names_refseq": "cell division cycle-associated protein 4; hematopoietic progenitor protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71963)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11482882;16546331;31219806;34428180;37949419", "class_list": "", "function": "ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4., [RefSeq, PubMed]; May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation., [UniProtKB]; The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1C0;Q921E8;Q99MP6", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CWM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZW2-1", "uniprot_id": "CENPN_MOUSE", "mass": 39240.0, "length": 337, "protein_name": "Centromere protein N", "gene_name": "Cenpn", "organism": "Mouse", "refseq_name": "centromere protein N", "refseq_ac": "NP_082407", "gene_names_uniprotkb": "Cenpn", "gene_names_refseq": "2610510J17Rik; Cenpn", "protein_names_uniprotkb": "Centromere protein N; CENP-N", "protein_names_refseq": "CENP-N; centromere protein N", "tax_id": 10090, "disease": "", "pathway": " (mmu:72155); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-606279); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE73;Q8R2W7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0007059 chromosome segregation;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D180-1", "uniprot_id": "CFA57_MOUSE", "mass": 144934.0, "length": 1249, "protein_name": "Cilia- and flagella-associated protein 57", "gene_name": "Cfap57", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 57", "refseq_ac": "NP_081065", "gene_names_uniprotkb": "Cfap57; Wdr65", "gene_names_refseq": "1110020C03Rik; C130004B06Rik; Cfap57; Gm1363; Wdr65", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 57; WD repeat-containing protein 65", "protein_names_refseq": "WD repeat domain 65; WD repeat-containing protein 65; cilia- and flagella-associated protein 57", "tax_id": 10090, "disease": "spermatogenic failure 95 (Disease Ontology:DOID:0070594); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:68625)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;21574244;31219806;36752199", "class_list": "", "function": "1110020C03Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Associates with components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility, and might act as an inner dynein arm (IDA) hub or linkage., [UniProtKB, UniProtKB]; Loss-of-function mutations in CFAP57 cause multiple morphological abnormalities of the flagella in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007338 single fertilization;GO:0044782 cilium organization;GO:0070286 axonemal dynein complex assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1L0-1", "uniprot_id": "CHCH2_MOUSE", "mass": 15661.0, "length": 153, "protein_name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2", "gene_name": "Chchd2", "organism": "Mouse", "refseq_name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor", "refseq_ac": "NP_077128", "gene_names_uniprotkb": "Chchd2", "gene_names_refseq": "Chchd2; Etohi6", "protein_names_uniprotkb": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 2 precursor; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial; ethanol induced 6", "tax_id": 10090, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 2 (Disease Ontology:DOID:0060214); Parkinson's disease 22 (Disease Ontology:DOID:0080504); spinal muscular atrophy, Jokela type (Disease Ontology:DOID:0081356); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:14004)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22872234;25428506;30084848;36288343;38341417", "class_list": "", "function": "CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUG8", "ec_number_list": "", "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0007005 mitochondrion organization;GO:1900037 regulation of cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D1L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4W2-1", "uniprot_id": "MFI_MOUSE", "mass": 36933.0, "length": 315, "protein_name": "Protein MFI", "gene_name": "Mfi", "organism": "Mouse", "refseq_name": "protein MFI isoform 1", "refseq_ac": "NP_083523", "gene_names_uniprotkb": "Mfi", "gene_names_refseq": "4930550C14Rik; Mfi", "protein_names_uniprotkb": "Protein MFI; Mitochondrial fission factor interactor; Protein C11orf65 homolog", "protein_names_refseq": "mitochondrial fission factor interactor; protein MFI isoform 1; protein MFI; uncharacterized protein C11orf65 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75311)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30059978", "class_list": "", "function": "Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5F8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:1903215 negative regulation of protein targeting to mitochondrion;GO:0090258 negative regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6G9-1", "uniprot_id": "CKLF5_MOUSE", "mass": 17389.0, "length": 156, "protein_name": "CKLF-like MARVEL transmembrane domain-containing protein 5", "gene_name": "Cmtm5", "organism": "Mouse", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 5 isoform 2", "refseq_ac": "NP_080342", "gene_names_uniprotkb": "Cmtm5; Cklfsf5", "gene_names_refseq": "1500005P16Rik; 2900052H21Rik; Cklfsf5; Cmtm5", "protein_names_uniprotkb": "CKLF-like MARVEL transmembrane domain-containing protein 5; Chemokine-like factor superfamily member 5", "protein_names_refseq": "CKLF-like MARVEL transmembrane domain-containing protein 5 isoform 2; CKLF-like MARVEL transmembrane domain-containing protein 5; chemokine-like factor super family 5; chemokine-like factor superfamily 5; chemokine-like factor superfamily member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67272)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "35274615;35820727;37626895", "class_list": "", "function": "Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB66", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0045662 negative regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7Q1-1", "uniprot_id": "CHIT1_MOUSE", "mass": 51112.0, "length": 464, "protein_name": "Chitotriosidase-1", "gene_name": "Chit1", "organism": "Mouse", "refseq_name": "chitotriosidase-1 isoform 2 precursor", "refseq_ac": "NP_001271453", "gene_names_uniprotkb": "Chit1", "gene_names_refseq": "2300002L19Rik; Chit1", "protein_names_uniprotkb": "Chitotriosidase-1; 3.2.1.14; Chitinase-1", "protein_names_refseq": "chitinase 1 (chitotriosidase); chitotriosidase-1 isoform 2 precursor; chitotriosidase-1", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); leprosy (Disease Ontology:DOID:1024); asbestosis (Disease Ontology:DOID:10320); silicosis (Disease Ontology:DOID:10325); sarcoidosis (Disease Ontology:DOID:11335); allergic disease (Disease Ontology:DOID:1205); aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); candidiasis (Disease Ontology:DOID:1508); Gaucher's disease (Disease Ontology:DOID:1926); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481); neuromyelitis optica (Disease Ontology:DOID:8869); intrinsic asthma (Disease Ontology:DOID:9360); allergic asthma (Disease Ontology:DOID:9415); bronchiectasis (Disease Ontology:DOID:9563)", "pathway": " (mmu:71884); (R-MMU-189085); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15923370;16005164;23685110;25605945;26079949;29891554;32853624;35984892", "class_list": "glycogene;glycosylhydrolase", "function": "CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages., [RefSeq, PubMed]; Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity., [RefSeq, PubMed]; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity)., [UniProtKB, PubMed]; No significant differences were observed between experimental autoimmune encephalitis and control groups for CHIT-1 expression., [RefSeq, PubMed]; These data show a detrimental role of chit1 in Klebsiella pneumoniae lung infections, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 38, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QJD2", "ec_number_list": "3.2.1.18;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;3.4.23.5;3.3.2.6;3.4.11.4;3.1.3.48;3.4.24.35;3.5.4.5;3.6.5.2;3.4.21.37;3.5.3.1;3.2.1.166;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.7.10.2;2.3.2.5;5.4.2.2;3.1.21.-;3.2.1.14;3.5.1.3;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0004568 chitinase activity;GO:0008843 endochitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0000272 polysaccharide catabolic process;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D7Q1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D871-1", "uniprot_id": "CEA18_MOUSE", "mass": 42215.0, "length": 376, "protein_name": "Cell adhesion molecule CEACAM18", "gene_name": "Ceacam18", "organism": "Mouse", "refseq_name": "cell adhesion molecule CEACAM18 isoform 1 precursor", "refseq_ac": "NP_082512", "gene_names_uniprotkb": "Ceacam18", "gene_names_refseq": "2010110O04Rik; Ceacam18", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM18; CEA cell adhesion molecule 18; Carcinoembryonic antigen-related cell adhesion molecule 18", "protein_names_refseq": "CEA-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 18; carcinoembryonic antigen-related cell adhesion molecule 1; cell adhesion molecule CEACAM18 isoform 1 precursor; cell adhesion molecule CEACAM18", "tax_id": 10090, "disease": "", "pathway": " (mmu:72431)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16139472;31219806", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8Q6-1", "uniprot_id": "OCAT1_MOUSE", "mass": 31376.0, "length": 287, "protein_name": "POU domain class 2-associating factor 2", "gene_name": "Pou2af2", "organism": "Mouse", "refseq_name": "POU domain class 2-associating factor 2 isoform 4", "refseq_ac": "NP_081493", "gene_names_uniprotkb": "Pou2af2", "gene_names_refseq": "1810046K07Rik; Oca-t1; Pou2af2", "protein_names_uniprotkb": "POU domain class 2-associating factor 2; Oct coactivator from tuft cells 1; POU class 2 homeobox-associating factor 2; Protein OCA-T1", "protein_names_refseq": "OCA-B homolog; POU class 2 homeobox-associating factor 2; POU domain class 2-associating factor 2 isoform 4; oct coactivator from tuft cells 1; protein POU2AF2; uncharacterized protein C11orf53 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69809)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35576971", "class_list": "", "function": "OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage., [RefSeq, PubMed]; Transcriptional coactivator of POU2F3 (By similarity). This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A5K1VW51", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043565 sequence-specific DNA binding;GO:0070974 POU domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D8Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9G3-1", "uniprot_id": "CHIC2_MOUSE", "mass": 19282.0, "length": 165, "protein_name": "Cysteine-rich hydrophobic domain-containing protein 2", "gene_name": "Chic2", "organism": "Mouse", "refseq_name": "cysteine-rich hydrophobic domain-containing protein 2", "refseq_ac": "NP_083126", "gene_names_uniprotkb": "Chic2", "gene_names_refseq": "1700081B18Rik; 4930502K01Rik; BTL; Chic2", "protein_names_uniprotkb": "Cysteine-rich hydrophobic domain-containing protein 2", "protein_names_refseq": "cysteine-rich hydrophobic domain 2 protein; cysteine-rich hydrophobic domain-containing protein 2", "tax_id": 10090, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:74277)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VG23;Q3T9U2;Q80ZT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane", "go_biological_process": "GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9G3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAR0-1", "uniprot_id": "CFA90_MOUSE", "mass": 20848.0, "length": 182, "protein_name": "Cilia- and flagella-associated protein 90", "gene_name": "Cfap90", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 90", "refseq_ac": "NP_081311", "gene_names_uniprotkb": "Cfap90", "gene_names_refseq": "1700001L19Rik; Cfap90", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 90; Y regulated sperm protein", "protein_names_refseq": "Y regulated sperm protein; cilia- and flagella-associated protein 90; uncharacterized protein C5orf49 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69315)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;37295417", "class_list": "", "function": "1700001L19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAU1-1", "uniprot_id": "CNPY3_MOUSE", "mass": 30538.0, "length": 276, "protein_name": "Protein canopy homolog 3", "gene_name": "Cnpy3", "organism": "Mouse", "refseq_name": "protein canopy homolog 3 isoform 2 precursor", "refseq_ac": "NP_001292917", "gene_names_uniprotkb": "Cnpy3; Prat4a; Tnrc5", "gene_names_refseq": "1600025D17Rik; 2410050O22Rik; CAG4A; Cnpy3; ERDA5; PRAT4A; Tnrc5", "protein_names_uniprotkb": "Protein canopy homolog 3; Protein associated with Tlr4; Trinucleotide repeat-containing gene 5 protein", "protein_names_refseq": "canopy 3 homolog; protein associated with Tlr4; protein associated with toll-like receptor 4; protein canopy homolog 3 isoform 2 precursor; protein canopy homolog 3; trinucleotide repeat-containing gene 5 protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 60 (Disease Ontology:DOID:0080432)", "pathway": " (mmu:72029); (R-MMU-1679131)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;12511604;16338228;16849487;17998391;18780723;19120473;20865800;21750661;29394991;30059200;30899004;31103627;36931208;37012514;40885482", "class_list": "", "function": "A novel rare variant of CNPY3 from familial NMOSD impairs the TLR-mediated immune response., [RefSeq, PubMed]; Association with PRAT4A is required for ligand-induced trafficking of TLR9 to endolysosomes Review article, [RefSeq, PubMed]; HuR regulates Paneth cell function by modulating TLR2 localization via posttranscriptional control of CNPY3 expression., [RefSeq, PubMed]; PRAT4A is a novel protein associated with toll-like receptor (TLR) 4 that regulates cell surface expression of receptor complex TLR4/MD-2., [RefSeq, PubMed]; PRAT4A regulates the subcellular distribution and response of multiple toll-like recaptors and is required for both innate and adaptive immune responses, [RefSeq, PubMed]; Single base mutant associates preferentially with TLR9, and differentially interacts with TLR2, 4 and 9, [RefSeq, PubMed]; The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells., [RefSeq, PubMed]; This gene encodes a member of the canopy family of proteins. The encoded protein may play a role in the maturation of toll-like receptors. Homozygous knockout mice for this gene show reduced cell surface expression of toll-like receptors and an impaired immune response including reduced production of cytokines in a mouse model of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q571I0;Q8BUS5;Q8BUV5;Q8C0C5", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9DAU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP78-1", "uniprot_id": "CHST7_MOUSE", "mass": 54767.0, "length": 484, "protein_name": "Carbohydrate sulfotransferase 7", "gene_name": "Chst7", "organism": "Mouse", "refseq_name": "carbohydrate sulfotransferase 7 precursor", "refseq_ac": "NP_068361", "gene_names_uniprotkb": "Chst7; Gst5", "gene_names_refseq": "2600013M07Rik; C6ST-2; Chst7; GST5; Gn6st-4; glcNAc6ST-4", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 7; 2.8.2.-; 2.8.2.17; C6ST-2; Chondroitin 6-sulfotransferase 2; GST-5; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; GlcNAc6ST-4; Gn6st-4; N-acetylglucosamine 6-O-sulfotransferase 4; mC6ST-2", "protein_names_refseq": "N-acetylglucosamine 6-O-sulfotransferase 1; N-acetylglucosamine 6-O-sulfotransferase 4; carbohydrate (N-acetylglucosamino) sulfotransferase 7; carbohydrate sulfotransferase 7 precursor; chondroitin 6-sulfotransferase 2; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:60322); (R-MMU-2022870)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;10913333;10956661", "class_list": "glycogene", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q99NB0", "ec_number_list": "2.8.2.17;2.8.2.21;2.8.2.-", "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008459 chondroitin 6-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EP78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHU3-1", "uniprot_id": "CDK20_MOUSE", "mass": 38379.0, "length": 346, "protein_name": "Cyclin-dependent kinase 20", "gene_name": "Cdk20", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase 20", "refseq_ac": "NP_444410", "gene_names_uniprotkb": "Cdk20; Ccrk; Cdch", "gene_names_refseq": "4932702G04Rik; CDCH; Ccrk; Cdk20; PNQLARE; p42", "protein_names_uniprotkb": "Cyclin-dependent kinase 20; 2.7.11.22; CAK-kinase p42; CDK-activating kinase p42; CDK-related protein kinase PNQLARE; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42", "protein_names_refseq": "CAK-kinase p42; CDK-activating kinase p42; CDK-related protein kinase PNQLARE; cell cycle-related kinase; cell division protein kinase 20; cyclin-dependent kinase 20; cyclin-dependent protein kinase H; cyclin-kinase-activating kinase p42", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:105278)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16552187;18508765;20159594;21747169;21750661;28939663;34428180", "class_list": "", "function": "Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis, [RefSeq, PubMed]; Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point., [RefSeq, PubMed]; Heart expresses a splice variant of CCRK, which promotes cardiac cell growth and survival; differs from the generic isoform in protein-protein interactions, substrate specificity and regulation of cell cycle; and is down-regulated in heart failure, [RefSeq, PubMed]; Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling., [UniProtKB, PubMed]; Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EDC2", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0097228 sperm principal piece", "go_biological_process": "GO:0021508 floor plate formation;GO:0051301 cell division;GO:0001843 neural tube closure;GO:0031076 embryonic camera-type eye development;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIL2-1", "uniprot_id": "CCL28_MOUSE", "mass": 14570.0, "length": 130, "protein_name": "C-C motif chemokine 28", "gene_name": "Ccl28", "organism": "Mouse", "refseq_name": "C-C motif chemokine 28 precursor", "refseq_ac": "NP_064675", "gene_names_uniprotkb": "Ccl28; Scya28", "gene_names_refseq": "CCK1; Ccl28; MEC; Scya28", "protein_names_uniprotkb": "C-C motif chemokine 28; Small-inducible cytokine A28", "protein_names_refseq": "C-C motif chemokine 28 precursor; C-C motif chemokine 28; chemokine (C-C motif) ligand 28; small-inducible cytokine A28", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); atopic dermatitis (Disease Ontology:DOID:3310); lymphopenia (Disease Ontology:DOID:614)", "pathway": " (mmu:56838); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10781587;12538707;33910988;34939465;37222480;38992792", "class_list": "", "function": "CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge. Publication Status: Online-Only, [RefSeq, PubMed]; CCL28 Downregulation Attenuates Pancreatic Cancer Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms., [RefSeq, PubMed]; CCL28 has dual functions in mucosal immunity as a chemokine attracting cells expressing CCR10 and/or CCR3 and also as an apically secreted molecule with a potent antimicrobial activity against a broad spectrum of microbes., [RefSeq, PubMed]; Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner., [UniProtKB]; Chronic stress induces wide-spread hyperalgesia: The involvement of spinal CCK1 receptors., [RefSeq, PubMed]; Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUK0-1", "uniprot_id": "CDKL2_MOUSE", "mass": 64056.0, "length": 568, "protein_name": "Cyclin-dependent kinase-like 2", "gene_name": "Cdkl2", "organism": "Mouse", "refseq_name": "cyclin-dependent kinase-like 2 isoform 2", "refseq_ac": "NP_001263244", "gene_names_uniprotkb": "Cdkl2; Kkiamre; Kkm", "gene_names_refseq": "5330436L21Rik; Cdkl2; KKIAMRE; Kkm", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 2; 2.7.11.22; Serine/threonine-protein kinase KKIAMRE", "protein_names_refseq": "cyclin dependent kinase like 2 (CDC2 related kinase); cyclin-dependent kinase-like 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:53886)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14605869;21750661;34428180", "class_list": "", "function": "Cdkl2 functions mainly in mature neurons and that mechanisms governing regulation of this gene expression in mice are distinct from those of immediate-early genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL60;Q3V3X7;Q9QYI1;Q9QYI2", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QUK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXS8-1", "uniprot_id": "CMLO5_MOUSE", "mass": 25735.0, "length": 227, "protein_name": "Probable N-acetyltransferase family 8 member 5", "gene_name": "Nat8f5", "organism": "Mouse", "refseq_name": "probable N-acetyltransferase family 8 member 5", "refseq_ac": "NP_075982", "gene_names_uniprotkb": "Nat8f5; Cml5", "gene_names_refseq": "1810018F03Rik; Cml5; Nat8f5", "protein_names_uniprotkb": "Probable N-acetyltransferase family 8 member 5; 2.3.1.-; Camello-like protein 5; Probable N-acetyltransferase CML5", "protein_names_refseq": "camello-like 5; camello-like protein 5; probable N-acetyltransferase CML5; probable N-acetyltransferase family 8 member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69049)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11397015;30084848;31599954;34428180", "class_list": "", "function": "May play a role in regulation of gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1G0;Q9D8Z0", "ec_number_list": "", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0001702 gastrulation with mouth forming second;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QXS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1R4-1", "uniprot_id": "CF047_MOUSE", "mass": 32015.0, "length": 293, "protein_name": "Uncharacterized protein C6orf47 homolog", "gene_name": "D17h6s53e", "organism": "Mouse", "refseq_name": "uncharacterized protein C6orf47 homolog", "refseq_ac": "NP_258438", "gene_names_uniprotkb": "D17h6s53e", "gene_names_refseq": "D17H6S53E; G4; NG34", "protein_names_uniprotkb": "Uncharacterized protein C6orf47 homolog", "protein_names_refseq": "uncharacterized protein C6orf47 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:114585)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14656967;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1E4-1", "uniprot_id": "CRTP1_MOUSE", "mass": 15108.0, "length": 142, "protein_name": "Cysteine-rich tail protein 1", "gene_name": "Cysrt1", "organism": "Mouse", "refseq_name": "cysteine-rich tail protein 1", "refseq_ac": "NP_080691", "gene_names_uniprotkb": "Cysrt1", "gene_names_refseq": "2310002J15Rik; Cysrt1", "protein_names_uniprotkb": "Cysteine-rich tail protein 1", "protein_names_refseq": "UPF0574 protein C9orf169 homolog; cysteine-rich tail protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67859)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7M7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0001533 cornified envelope", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D1E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q816-1", "uniprot_id": "CP2W1_MOUSE", "mass": 54438.0, "length": 493, "protein_name": "Cytochrome P450 2W1", "gene_name": "Cyp2w1", "organism": "Mouse", "refseq_name": "cytochrome P450 2W1 precursor", "refseq_ac": "NP_001153737", "gene_names_uniprotkb": "Cyp2w1", "gene_names_refseq": "Cyp2w1; Gm455", "protein_names_uniprotkb": "Cytochrome P450 2W1; 1.14.14.-", "protein_names_refseq": "cytochrome P450 2W1 precursor; cytochrome P450 2W1", "tax_id": 10090, "disease": "", "pathway": " (mmu:545817); (R-MMU-211958); (R-MMU-211981)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;21920951;25844926", "class_list": "", "function": "A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism. Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates. Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids. May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Results show the developmental expression of CYP2W1 in the GI tract mediated by epigenetic modifications, its specific location, and regulation by anticancer drugs which can be considered as an adjuvant therapy of colon and hepatic cancers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;1.14.13.n7;1.14.13.-;4.2.1.152;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0005503 all-trans retinal binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006644 phospholipid metabolic process;GO:0006082 organic acid metabolic process;GO:0034653 retinoic acid catabolic process;GO:0046222 aflatoxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LJ0-1", "uniprot_id": "CT2NL_MOUSE", "mass": 69841.0, "length": 638, "protein_name": "CTTNBP2 N-terminal-like protein", "gene_name": "Cttnbp2nl", "organism": "Mouse", "refseq_name": "CTTNBP2 N-terminal-like protein", "refseq_ac": "NP_001156804", "gene_names_uniprotkb": "Cttnbp2nl; Kiaa1433", "gene_names_refseq": "Cttnbp2nl; mKIAA1433", "protein_names_uniprotkb": "CTTNBP2 N-terminal-like protein", "protein_names_refseq": "CTTNBP2 N-terminal-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:80281)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15345747;19144319;21183079;21750661;23015759;28528544;32782141;32848054;34678516;34887587", "class_list": "", "function": "Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPR0;Q8BSV1;Q922L8", "ec_number_list": "", "go_molecular_function": "GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber;GO:0090443 FAR/SIN/STRIPAK complex;GO:0005737 cytoplasm", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:0032410 negative regulation of transporter activity;GO:0034763 negative regulation of transmembrane transport;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99LJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q09143-1", "uniprot_id": "CTR1_MOUSE", "mass": 67092.0, "length": 622, "protein_name": "High affinity cationic amino acid transporter 1", "gene_name": "Slc7a1", "organism": "Mouse", "refseq_name": "high affinity cationic amino acid transporter 1", "refseq_ac": "NP_001288353", "gene_names_uniprotkb": "Slc7a1; Atrc1; Rec-1", "gene_names_refseq": "4831426K01Rik; Atrc-1; Atrc1; CAT-1; Cat1; ERR; EcoR; Rec-1; Rev-1; Slc7a1; mCAT-1", "protein_names_uniprotkb": "High affinity cationic amino acid transporter 1; CAT-1; CAT1; ERR; EcoR; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; Solute carrier family 7 member 1; System Y+ basic amino acid transporter", "protein_names_refseq": "cationic amino acid transporter 1; ecotropic retroviral leukemia receptor; ecotropic retrovirus receptor; high affinity cationic amino acid transporter 1; solute carrier family 7 member 1; system Y+ basic amino acid transporter", "tax_id": 10090, "disease": "proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Disease Ontology:DOID:0111666)", "pathway": " (mmu:11987); (R-MMU-352230)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "16075062;1652100;1908564;19144319;21183079;21750661;22081021;2541919;25683716;26495903;28973536;31219806;33034619;34203471;34428180;36253807;38547677;9174363", "class_list": "", "function": "(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus., [UniProtKB, PubMed, PubMed]; Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure., [RefSeq, PubMed]; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues., [UniProtKB, PubMed, PubMed, PubMed]; The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P30824", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0001618 virus receptor activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0042102 positive regulation of T cell proliferation;GO:0032006 regulation of TOR signaling;GO:0097638 L-arginine import across plasma membrane;GO:0015819 lysine transport;GO:1903810 L-histidine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q09143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03940-1", "uniprot_id": "CP21A_MOUSE", "mass": 55328.0, "length": 487, "protein_name": "Steroid 21-hydroxylase", "gene_name": "Cyp21a1; Cyp21", "organism": "Mouse", "refseq_name": "steroid 21-hydroxylase", "refseq_ac": "NP_034125", "gene_names_uniprotkb": "Cyp21a1; Cyp21; Cyp21a-1; Cyp21a1", "gene_names_refseq": "21-OH; 21OHA; 21OHB; 21OH; CYP21OH-A; Cyp21-ps1; Cyp21B; Cyp21a1; Cyp21a2-ps; Cyp21a2ps; Cyp21; Oh21-1; Oh21-2", "protein_names_uniprotkb": "Steroid 21-hydroxylase; 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21", "protein_names_refseq": "21-OHase; 21-hydroxylase; cytochrome P-450c21; cytochrome P-450; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450 hydroxylase A; cytochrome P450, 21, pseudogene; cytochrome P450, 21, steroid 21 hydroxylase; cytochrome P450, family 21, subfamily a, polypeptide 2, pseudogene; cytochrome P450-C21; steroid 21-hydroxylase", "tax_id": 10090, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811)", "pathway": " (mmu:13079); (R-MMU-193993); (R-MMU-194002); (R-MMU-211976)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14656967;1918990;21750661;3491986;38171371;3874401", "class_list": "", "function": "A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JP50;O88304;Q64510;Q9QX14", "ec_number_list": "1.14.14.16", "go_molecular_function": "GO:0005506 iron ion binding;GO:0005496 steroid binding;GO:0020037 heme binding;GO:0004509 steroid 21-monooxygenase activity;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006704 glucocorticoid biosynthetic process;GO:0006705 mineralocorticoid biosynthetic process;GO:0008202 steroid metabolic process;GO:0034651 cortisol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1RLL3-1", "uniprot_id": "CPNE9_MOUSE", "mass": 61852.0, "length": 553, "protein_name": "Copine-9", "gene_name": "Cpne9", "organism": "Mouse", "refseq_name": "copine-9", "refseq_ac": "NP_733773", "gene_names_uniprotkb": "Cpne9", "gene_names_refseq": "A730016F12Rik; Cpne9; mKIAA4217", "protein_names_uniprotkb": "Copine-9; Copine IX", "protein_names_refseq": "copine IX; copine-9", "tax_id": 10090, "disease": "", "pathway": " (mmu:211232)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C990", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RLL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88962-1", "uniprot_id": "CP8B1_MOUSE", "mass": 57706.0, "length": 500, "protein_name": "7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase", "gene_name": "Cyp8b1", "organism": "Mouse", "refseq_name": "7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase", "refseq_ac": "NP_034142", "gene_names_uniprotkb": "Cyp8b1; Cyp12", "gene_names_refseq": "Cyp8b1", "protein_names_uniprotkb": "7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; 1.14.14.139; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; CYPVIIIB1; Cytochrome P450 8B1; Sterol 12-alpha-hydroxylase", "protein_names_refseq": "7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase", "tax_id": 10090, "disease": "extrahepatic cholestasis (Disease Ontology:DOID:13619)", "pathway": " (mmu:13124); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807); (R-MMU-211979); (R-MMU-211994); (R-MMU-2162123)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10051404;12393855;21750661;28377401;29066462;30084848;33016185;34428180;37453647", "class_list": "", "function": "Cyp8b1(-/-) mice were resistant to Western diet-induced body weight gain, hepatic steatosis, and insulin resistance., [RefSeq, PubMed]; Feedback regulation of the rate-limiting biosynthetic enzyme CYP7A1 is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism., [RefSeq, PubMed]; Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features., [RefSeq, PubMed]; Sterol 12-alpha-hydroxylase involved in primary bile acid biosynthesis by catalyzing the 12alpha-hydroxylation of key intermediates including 7alpha-hydroxycholest-4-en-3-one, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate and chenodeoxycholate along the classic pathway (By similarity). May also hydroxylate 5beta-cholestane-3alpha,7alpha-diol. Functions as a monooxygenase, inserting one atom of molecular oxygen into substrates while reducing the second to water, using electrons supplied by NADPH via cytochrome P450 reductase (CPR) (By similarity). Controls biliary balance of cholic acid and chenodeoxycholic acid, thereby regulating intestinal absorption of dietary lipids (PubMed:12393855, PubMed:28377401)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The altered bile acid composition of Cyp8b1(-/-) mice preserves metabolic and respiratory function by repressing hepatic De Novo lipogenesis and driving favorable changes in gut antimicrobial responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R217", "ec_number_list": "5.3.99.4;4.2.1.152;1.14.14.139", "go_molecular_function": "GO:0008397 sterol 12-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0045797 positive regulation of intestinal cholesterol absorption", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60753-1", "uniprot_id": "CTF1_MOUSE", "mass": 21509.0, "length": 203, "protein_name": "Cardiotrophin-1", "gene_name": "Ctf1", "organism": "Mouse", "refseq_name": "cardiotrophin-1 isoform 1", "refseq_ac": "NP_031821", "gene_names_uniprotkb": "Ctf1", "gene_names_refseq": "CT-1; Ctf1", "protein_names_uniprotkb": "Cardiotrophin-1; CT-1", "protein_names_refseq": "cardiotrophin-1 isoform 1", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13019); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;33047392;35722965;7738033;7862649;8625793;9030543;9050750", "class_list": "", "function": "Cardiotrophin-1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting-induced fatty acid mobilization., [RefSeq, PubMed]; Functions as a cytokine that binds to the LIF receptor complex (PubMed:7738033, PubMed:9030543). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:7738033, PubMed:9030543). Functionnally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (PubMed:7862649, PubMed:8625793, PubMed:9050750). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (PubMed:9030543). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:9030543). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (PubMed:9030543)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor., [UniProtKB, UniProtKB, UniProtKB]; Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development;GO:0048666 neuron development;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0007259 cell surface receptor signaling pathway via JAK-STAT;GO:0048861 leukemia inhibitory factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33267-1", "uniprot_id": "CP2F2_MOUSE", "mass": 55949.0, "length": 491, "protein_name": "Cytochrome P450 2F2", "gene_name": "Cyp2f2", "organism": "Mouse", "refseq_name": "cytochrome P450 2F2", "refseq_ac": "NP_031843", "gene_names_uniprotkb": "Cyp2f2; Cyp2f-2", "gene_names_refseq": "Cyp2f2; Cyp2f", "protein_names_uniprotkb": "Cytochrome P450 2F2; 1.14.14.-; CYPIIF2; Cytochrome P450-NAH-2; Naphthalene dehydrogenase; Naphthalene hydroxylase", "protein_names_refseq": "CYPIIF2; cytochrome P450 2F2; cytochrome P450, 2f2; cytochrome P450-NAH-2; naphthalene dehydrogenase; naphthalene hydroxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:13107); (R-MMU-211935); (R-MMU-211981); (R-MMU-211999)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "16479539;1742282;1981702;21750661;25428506;30084848;34428180;36210013;37453647", "class_list": "", "function": "Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or club cells in lung., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;1.14.13.n7;4.2.1.152;5.3.99.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009636 response to toxic substance;GO:0019373 epoxygenase P450 pathway;GO:0018979 trichloroethylene metabolic process;GO:1901170 naphthalene catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P33267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56392-1", "uniprot_id": "CX7A1_MOUSE", "mass": 8986.0, "length": 80, "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "Cox7a1", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 7A1, mitochondrial isoform 2 precursor", "refseq_ac": "NP_034074", "gene_names_uniprotkb": "Cox7a1; Cox7ah; Cox7a", "gene_names_refseq": "COX7AH; COX7AM; COX7A; Cox7a1", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A1, mitochondrial; Cytochrome c oxidase subunit VIIa-H; Cytochrome c oxidase subunit VIIa-M; Cytochrome c oxidase subunit VIIa-heart; Cytochrome c oxidase subunit VIIa-muscle", "protein_names_refseq": "cytochrome c oxidase subunit 7A1, mitochondrial isoform 2 precursor; cytochrome c oxidase subunit 7A1, mitochondrial; cytochrome c oxidase subunit VIIa 1; cytochrome c oxidase subunit VIIa-H; cytochrome c oxidase subunit VIIa-M; cytochrome c oxidase subunit VIIa-heart; cytochrome c oxidase subunit VIIa-muscle", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (mmu:12865); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12853116;21750661;22119795;22869013;26635001;34428180;36288343;37507081;9615220", "class_list": "", "function": "A significasnt decrease in COX7AH polypeptide was observed in the myocardium of infected mice at 110 dpi, the repression being amplified with chronic disease development (330 dpi)., [RefSeq, PubMed]; Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:22119795, PubMed:22869013). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (PubMed:26635001)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation;GO:1902600 proton transmembrane transport;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P56392-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59054-1", "uniprot_id": "CSRN1_MOUSE", "mass": 62525.0, "length": 583, "protein_name": "Cysteine/serine-rich nuclear protein 1", "gene_name": "Csrnp1", "organism": "Mouse", "refseq_name": "cysteine/serine-rich nuclear protein 1", "refseq_ac": "NP_695019", "gene_names_uniprotkb": "Csrnp1; Axud1; Taip3", "gene_names_refseq": "4931429D10Rik; Axud1; CSRNP-1; Csrnp1; URAX1; taip-3", "protein_names_uniprotkb": "Cysteine/serine-rich nuclear protein 1; Axin-1 up-regulated gene 1 protein; CSRNP-1; TAIP-3; TGF-beta-induced apoptosis protein 3", "protein_names_refseq": "AXIN1 up-regulated 1; TGF-beta induced apoptosis protein 3; axin-1 up-regulated gene 1 protein; cysteine/serine-rich nuclear protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215418)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17726538;21750661;23533084;28830684;31219806;31599954;34428180", "class_list": "", "function": "Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis., [UniProtKB, PubMed]; Significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USP7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28649-1", "uniprot_id": "CP19A_MOUSE", "mass": 58015.0, "length": 503, "protein_name": "Aromatase", "gene_name": "Cyp19a1", "organism": "Mouse", "refseq_name": "aromatase", "refseq_ac": "NP_001335100", "gene_names_uniprotkb": "Cyp19a1; Arom; Cyp19", "gene_names_refseq": "ArKO; Ar; Cyp19a1; Cyp19; Int-5; Int5; p450arom", "protein_names_uniprotkb": "Aromatase; 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase", "protein_names_refseq": "CYPXIX; aromatase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase; estrogen synthase", "tax_id": 10090, "disease": "aromatase excess syndrome (Disease Ontology:DOID:0090122); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:13075); (R-MMU-193144); (R-MMU-211976)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1897929;21750661;39183304", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;4.2.1.152;1.14.14.14", "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043197 dendritic spine;GO:0043679 axon terminus", "go_biological_process": "GO:0002677 negative regulation of chronic inflammatory response;GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0097720 calcineurin-mediated signaling;GO:0030540 female genitalia development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ16-1", "uniprot_id": "CXCR6_MOUSE", "mass": 40468.0, "length": 351, "protein_name": "C-X-C chemokine receptor type 6", "gene_name": "Cxcr6", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 6", "refseq_ac": "NP_109637", "gene_names_uniprotkb": "Cxcr6", "gene_names_refseq": "BONZO; Cxcr6; STRL33", "protein_names_uniprotkb": "C-X-C chemokine receptor type 6; CXC-R6; CXCR-6", "protein_names_refseq": "C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; chemokine (C-X-C motif) receptor 6", "tax_id": 10090, "disease": "systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:80901); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11017100;21750661;30084848;34428180;36210013;36383116", "class_list": "", "function": "Receptor for the C-X-C chemokine CXCL16., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA95;Q9ERH5", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019958 C-X-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQ16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFG8-1", "uniprot_id": "CS1B_MOUSE", "mass": 76700.0, "length": 688, "protein_name": "Complement C1s-1 subcomponent", "gene_name": "C1s2", "organism": "Mouse", "refseq_name": "complement C1s-1 subcomponent precursor", "refseq_ac": "NP_776289", "gene_names_uniprotkb": "C1s2; C1sb; C1s; Gm5077", "gene_names_refseq": "C1s2; C1sb; EG317677; Gm5077", "protein_names_uniprotkb": "Complement C1s-1 subcomponent; 3.4.21.42; C1 esterase; Complement C1s-B subcomponent; Complement component 1 subcomponent s-B; Complement component 1, S subcomponent 2", "protein_names_refseq": "C1 esterase; complement C1s-1 subcomponent precursor; complement C1s-1 subcomponent; complement C1s-B subcomponent; complement component 1 subcomponent s-B; complement component 1, s-B subcomponent; complement component C1SB", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome periodontal type 2 (Disease Ontology:DOID:0080987)", "pathway": " (mmu:317677); (R-MMU-173623); (R-MMU-977606)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12513694;21750661", "class_list": "", "function": "Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.42;3.4.21.41", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005602 complement component C1 complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJQ3-1", "uniprot_id": "D19L4_MOUSE", "mass": 83604.0, "length": 722, "protein_name": "Probable C-mannosyltransferase DPY19L4", "gene_name": "Dpy19l4", "organism": "Mouse", "refseq_name": "probable C-mannosyltransferase DPY19L4", "refseq_ac": "NP_001074670", "gene_names_uniprotkb": "Dpy19l4; Gm1023", "gene_names_refseq": "Dpy19l4; Gm1023; Narg3", "protein_names_uniprotkb": "Probable C-mannosyltransferase DPY19L4; 2.4.1.-; Dpy-19-like protein 4; Protein dpy-19 homolog 4", "protein_names_refseq": "NMDA receptor-regulated gene 3; dpy-19-like protein 4; probable C-mannosyltransferase DPY19L4; protein dpy-19 homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:381510)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31219806;34428180;36210013", "class_list": "glycogene;glycosyltransferase", "function": "Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RW18;Q3T9A8", "ec_number_list": "", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "A2AJQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B9EJR8-1", "uniprot_id": "DAAF5_MOUSE", "mass": 93851.0, "length": 853, "protein_name": "Dynein axonemal assembly factor 5", "gene_name": "Dnaaf5", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 5 isoform 1", "refseq_ac": "NP_001074734", "gene_names_uniprotkb": "Dnaaf5; Heatr2", "gene_names_refseq": "Dnaaf5; Heatr2", "protein_names_uniprotkb": "Dynein axonemal assembly factor 5; HEAT repeat-containing protein 2", "protein_names_refseq": "HEAT repeat-containing protein 2; dynein assembly factor 5, axonemal; dynein axonemal assembly factor 5 isoform 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia 18 (Disease Ontology:DOID:0110604); male infertility (Disease Ontology:DOID:12336); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:433956)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25232951;25428506;31219806;34428180;39627609", "class_list": "", "function": "Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0072686 mitotic spindle", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B9EJR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K353-1", "uniprot_id": "CYTM1_MOUSE", "mass": 11402.0, "length": 104, "protein_name": "Cysteine-rich transmembrane module-containing protein 1", "gene_name": "Cystm1", "organism": "Mouse", "refseq_name": "cysteine-rich transmembrane module-containing protein 1 isoform 1", "refseq_ac": "NP_001355566", "gene_names_uniprotkb": "Cystm1; 0610010O12Rik", "gene_names_refseq": "0610010O12Rik; Cystm1", "protein_names_uniprotkb": "Cysteine-rich transmembrane module-containing protein 1", "protein_names_refseq": "UPF0467 protein C5orf32 homolog; cysteine-rich and transmembrane domain-containing protein 1; cysteine-rich transmembrane module-containing protein 1 isoform 1; cysteine-rich transmembrane module-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66060); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMU1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1Y2-1", "uniprot_id": "MERB1_MOUSE", "mass": 23465.0, "length": 203, "protein_name": "bMERB domain-containing protein 1", "gene_name": "Bmerb1", "organism": "Mouse", "refseq_name": "bMERB domain-containing protein 1", "refseq_ac": "NP_653101", "gene_names_uniprotkb": "Bmerb1; 2900011O08Rik", "gene_names_refseq": "2900011O08Rik; Bmerb1; MINP", "protein_names_uniprotkb": "bMERB domain-containing protein 1; Uncharacterized protein C16orf45 homolog", "protein_names_refseq": "bMERB domain-containing protein 1; migration inhibitory protein; uncharacterized protein C16orf45 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67254)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25099998;34428180", "class_list": "", "function": "The newly identified migration inhibitory protein (MINP) regulates the radial migration in the developing neocortex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVX0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0021822 negative regulation of cell motility involved in cerebral cortex radial glia guided migration;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R1Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z070-1", "uniprot_id": "CS081_MOUSE", "mass": 22145.0, "length": 196, "protein_name": "Putative uncharacterized protein C19orf81 homolog", "gene_name": "1700008O03Rik", "organism": "Mouse", "refseq_name": "putative uncharacterized protein C19orf81 homolog", "refseq_ac": "NP_081325", "gene_names_uniprotkb": "1700008O03Rik", "gene_names_refseq": "1700008O03Rik", "protein_names_uniprotkb": "Putative uncharacterized protein C19orf81 homolog", "protein_names_refseq": "putative uncharacterized protein C19orf81 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69349)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAJ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJU9-1", "uniprot_id": "CRBB3_MOUSE", "mass": 24291.0, "length": 211, "protein_name": "Beta-crystallin B3", "gene_name": "Crybb3", "organism": "Mouse", "refseq_name": "beta-crystallin B3", "refseq_ac": "NP_001153122", "gene_names_uniprotkb": "Crybb3", "gene_names_refseq": "Crybb3", "protein_names_uniprotkb": "Beta-crystallin B3; Beta-B3 crystallin", "protein_names_refseq": "beta-B3 crystallin; beta-crystallin B3", "tax_id": 10090, "disease": "cataract 22 multiple types (Disease Ontology:DOID:0110268)", "pathway": " (mmu:12962)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30646012", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4A3-1", "uniprot_id": "DACT1_MOUSE", "mass": 84306.0, "length": 778, "protein_name": "Dapper homolog 1", "gene_name": "Dact1", "organism": "Mouse", "refseq_name": "dapper homolog 1 isoform 2", "refseq_ac": "NP_067507", "gene_names_uniprotkb": "Dact1; Thyex3", "gene_names_refseq": "4921528D17Rik; DAPPER1; DAPPER; Dact1; FRODO; Frd1; Frodo1; MDpr1; MTNG3; THYEX3", "protein_names_uniprotkb": "Dapper homolog 1; Dapper antagonist of catenin 1; Frodo homolog; MDpr1; Thymus-expressed novel gene 3 protein", "protein_names_refseq": "dapper 1; dapper antagonist of catenin 1; dapper homolog 1 isoform 2; dapper homolog 1, antagonist of beta-catenin; frodo homolog; thymus expressed gene 3; thymus-expressed novel gene 3 protein", "tax_id": 10090, "disease": "Townes-Brocks syndrome (Disease Ontology:DOID:0050887)", "pathway": " (mmu:59036); (R-MMU-4641258)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11970895;14636582;16278878;16881060;17197390;19073771;19701191;20145239;20335472;21718540;21750661;30684546;31978940", "class_list": "", "function": "Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy., [RefSeq, PubMed]; Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis, [RefSeq, PubMed]; High DACT1 expression is associated with type 2 diabetes mellitus., [RefSeq, PubMed]; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VG9;Q8BP49;Q9JK89", "ec_number_list": "", "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0005080 protein kinase C binding;GO:0008013 beta-catenin binding;GO:0051018 protein kinase A binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:1904864 negative regulation of beta-catenin-TCF complex assembly;GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R4A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922R1-1", "uniprot_id": "PHAF1_MOUSE", "mass": 47416.0, "length": 422, "protein_name": "Phagosome assembly factor 1", "gene_name": "Phaf1", "organism": "Mouse", "refseq_name": "phagosome assembly factor 1 isoform 2", "refseq_ac": "NP_663579", "gene_names_uniprotkb": "Phaf1; D230025D16Rik", "gene_names_refseq": "D230025D16Rik; Lin10; Mytho; Phaf1", "protein_names_uniprotkb": "Phagosome assembly factor 1", "protein_names_refseq": "UPF0183 protein C16orf70 homolog; lin-10 homolog; phagosome assembly factor 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234678)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;31599954;38869949", "class_list": "", "function": "C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PER2", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0030425 dendrite;GO:0030672 synaptic vesicle membrane;GO:0005802 trans-Golgi network;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q922R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1L6-1", "uniprot_id": "CP074_MOUSE", "mass": 11870.0, "length": 111, "protein_name": "Uncharacterized protein C16orf74 homolog", "gene_name": "Clmb", "organism": "Mouse", "refseq_name": "uncharacterized protein C16orf74 homolog", "refseq_ac": "NP_932105", "gene_names_uniprotkb": "Clmb; 1190005I06Rik", "gene_names_refseq": "1190005I06Rik; Clmb; Mict1", "protein_names_uniprotkb": "Uncharacterized protein C16orf74 homolog", "protein_names_refseq": "uncharacterized protein C16orf74 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68918)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PUE0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K1L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K199-1", "uniprot_id": "COXM2_MOUSE", "mass": 9419.0, "length": 79, "protein_name": "COX assembly mitochondrial protein 2 homolog", "gene_name": "Cmc2", "organism": "Mouse", "refseq_name": "COX assembly mitochondrial protein 2 homolog", "refseq_ac": "NP_081120", "gene_names_uniprotkb": "Cmc2; 2310061C15Rik", "gene_names_refseq": "1110046L09Rik; 2310061C15Rik; Cmc2; DC13", "protein_names_uniprotkb": "COX assembly mitochondrial protein 2 homolog", "protein_names_refseq": "COX assembly mitochondrial protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66531)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36288343", "class_list": "", "function": "May be involved in cytochrome c oxidase biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEV6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56567-1", "uniprot_id": "CYTA_MOUSE", "mass": 10929.0, "length": 97, "protein_name": "Cystatin-A", "gene_name": "Csta1; Csta", "organism": "Mouse", "refseq_name": "cystatin-A", "refseq_ac": "NP_001028411", "gene_names_uniprotkb": "Csta1; Csta; Csta1; Csta", "gene_names_refseq": "Csta1; Csta", "protein_names_uniprotkb": "Cystatin-A; Cystatin-A1; Stefin-A", "protein_names_refseq": "cystatin-A; stefin-A", "tax_id": 10090, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523)", "pathway": " (mmu:209294)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19838297;21750661;25785582;37118283", "class_list": "", "function": "A novel pathway of CSTA regulation involving Dsg2 Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1 Publication Status: Online-Only, [RefSeq, PubMed]; Skin chronological aging drives age-related bone loss via secretion of cystatin-A. Erratum:[Nat Aging. 2023 Aug;3(8):1037. doi: 10.1038/s43587-023-00458-2. PMID: 37365344], [RefSeq, PubMed]; This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV05", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56567-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVJ5-1", "uniprot_id": "CRBB1_MOUSE", "mass": 28003.0, "length": 250, "protein_name": "Beta-crystallin B1", "gene_name": "Crybb1", "organism": "Mouse", "refseq_name": "beta-crystallin B1", "refseq_ac": "NP_001299822", "gene_names_uniprotkb": "Crybb1", "gene_names_refseq": "3110006K12Rik; BB1CRY; Crybb1", "protein_names_uniprotkb": "Beta-crystallin B1; Beta-B1 crystallin", "protein_names_refseq": "beta-crystallin B1", "tax_id": 10090, "disease": "cataract 17 multiple types (Disease Ontology:DOID:0110270); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12960)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WVJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIW9-1", "uniprot_id": "CTF18_MOUSE", "mass": 108137.0, "length": 969, "protein_name": "Chromosome transmission fidelity protein 18 homolog", "gene_name": "Chtf18", "organism": "Mouse", "refseq_name": "chromosome transmission fidelity protein 18 homolog isoform 2", "refseq_ac": "NP_663384", "gene_names_uniprotkb": "Chtf18; Ctf18", "gene_names_refseq": "6030457M03Rik; CTF18; Chl12; Chtf18", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 18 homolog", "protein_names_refseq": "CTF18, chromosome transmission fidelity factor 18 homolog; Chl12 homolog; chromosome transmission fidelity protein 18 homolog isoform 2; chromosome transmission fidelity protein 18 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:214901); (R-MMU-174411)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18299400;21750661;21952136;23133398;25153642;25428506;30084848;32219340", "class_list": "", "function": "CHTF18 ensures the quantity and quality of the ovarian reservedagger., [RefSeq, PubMed]; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1R7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:0007140 male meiotic nuclear division;GO:0048468 cell development;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BIW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61476-1", "uniprot_id": "DAF2_MOUSE", "mass": 44511.0, "length": 407, "protein_name": "Complement decay-accelerating factor transmembrane isoform", "gene_name": "Cd55b", "organism": "Mouse", "refseq_name": "complement decay-accelerating factor transmembrane isoform isoform 2 precursor", "refseq_ac": "NP_001304290", "gene_names_uniprotkb": "Cd55b; Daf2", "gene_names_refseq": "Cd55b; Daf-TM; Daf2; Daf; TM-DAF", "protein_names_uniprotkb": "Complement decay-accelerating factor transmembrane isoform; DAF-TM", "protein_names_refseq": "complement decay-accelerating factor transmembrane isoform isoform 2 precursor; complement-transmembrane; decay accelerating factor 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); protein-losing enteropathy (Disease Ontology:DOID:10611); breast cancer (Disease Ontology:DOID:1612); endometrial adenocarcinoma (Disease Ontology:DOID:2870); cervical cancer (Disease Ontology:DOID:4362); proteinuria (Disease Ontology:DOID:576); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:13137)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;7545711", "class_list": "", "function": "This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]., [RefSeq]; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLT3", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0008289 lipid binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045087 innate immune response;GO:0002726 positive regulation of T cell cytokine production;GO:0045916 negative regulation of complement activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61476-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJV0-1", "uniprot_id": "CRBA4_MOUSE", "mass": 22469.0, "length": 196, "protein_name": "Beta-crystallin A4", "gene_name": "Cryba4", "organism": "Mouse", "refseq_name": "beta-crystallin A4 isoform 2", "refseq_ac": "NP_001299813", "gene_names_uniprotkb": "Cryba4", "gene_names_refseq": "Cryba4", "protein_names_uniprotkb": "Beta-crystallin A4; Beta-A4 crystallin", "protein_names_refseq": "beta-A4 crystallin; beta-crystallin A4 isoform 2; beta-crystallin A4", "tax_id": 10090, "disease": "cataract 23 (Disease Ontology:DOID:0110271); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12959)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29683234;30646012", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]; Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon-aponeurosis hyperplasia. Erratum:[Oral Dis. 2023 Mar;29(2):854. doi: 10.1111/odi.13956. PMID: 34450689], [RefSeq, PubMed]; The current study shows for the first time that two highly expressed lens crystallin genes, Cryba4 and Crybb1, can be simultaneously transcribed from adjacent bidirectional promoters and do not show nuclear accumulation., [RefSeq, PubMed]; This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. Certain mutations in the human ortholog of this gene are associated with cataract and bilateral microphthalmia. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QMW4-1", "uniprot_id": "CP096_MOUSE", "mass": 127660.0, "length": 1145, "protein_name": "Uncharacterized protein C16orf96 homolog", "gene_name": "4930562C15Rik", "organism": "Mouse", "refseq_name": "uncharacterized protein C16orf96 homolog", "refseq_ac": "NP_084468", "gene_names_uniprotkb": "4930562C15Rik", "gene_names_refseq": "4930562C15Rik", "protein_names_uniprotkb": "Uncharacterized protein C16orf96 homolog", "protein_names_refseq": "uncharacterized protein C16orf96 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78809)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V087", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9QMW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61475-1", "uniprot_id": "DAF1_MOUSE", "mass": 42618.0, "length": 390, "protein_name": "Complement decay-accelerating factor, GPI-anchored", "gene_name": "Cd55", "organism": "Mouse", "refseq_name": "complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein", "refseq_ac": "NP_034146", "gene_names_uniprotkb": "Cd55; Cd55a; Daf1; Daf", "gene_names_refseq": "Cd55; Daf-GPI; Daf1; Daf; GPI-DAF", "protein_names_uniprotkb": "Complement decay-accelerating factor, GPI-anchored; DAF-GPI", "protein_names_refseq": "CD55 antigen; Cromer blood group; GPI anchor addition signal; complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein; complement decay-accelerating factor, GPI-anchored; complement-glycosylphosphatidylinositol; decay accelerating factor 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); protein-losing enteropathy (Disease Ontology:DOID:10611); breast cancer (Disease Ontology:DOID:1612); endometrial adenocarcinoma (Disease Ontology:DOID:2870); cervical cancer (Disease Ontology:DOID:4362); proteinuria (Disease Ontology:DOID:576); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (mmu:13136); (R-MMU-373080); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-977606)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10417349;21750661;32152506;34428180;38372645;39342308;7545711;8671624;9435343", "class_list": "", "function": "Critical Role of CD55 in Controlling Wound Healing., [RefSeq, PubMed]; Exercise training upregulates CD55 to suppress complement-mediated synaptic phagocytosis in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]., [RefSeq]; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97732;Q3TU32;Q4FJS4;Q61397;Q76N72;Q921P0;Q9R1C1", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0008289 lipid binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045087 innate immune response;GO:0002726 positive regulation of T cell cytokine production;GO:0045916 negative regulation of complement activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61475-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71B07-1", "uniprot_id": "D19L3_MOUSE", "mass": 82990.0, "length": 716, "protein_name": "Protein C-mannosyl-transferase DPY19L3", "gene_name": "Dpy19l3", "organism": "Mouse", "refseq_name": "protein C-mannosyl-transferase DPY19L3", "refseq_ac": "NP_848819", "gene_names_uniprotkb": "Dpy19l3", "gene_names_refseq": "6030410G08; 9330164H19Rik; Dpy19l3", "protein_names_uniprotkb": "Protein C-mannosyl-transferase DPY19L3; 2.4.1.-; Dpy-19-like protein 3; Protein dpy-19 homolog 3", "protein_names_refseq": "dpy-19-like 3; dpy-19-like protein 3; probable C-mannosyltransferase DPY19L3; protein C-mannosyl-transferase DPY19L3; protein dpy-19 homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:233115)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19224205;20173027;21750661;25428507;25605945;28202721;31219806;34428180;34577156;35820727;37828378", "class_list": "glycogene;glycosyltransferase", "function": "C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:28202721). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (By similarity). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (PubMed:28202721)., [UniProtKB, UniProtKB, PubMed]; Involvement of DPY19L3 in Myogenic Differentiation of C2C12 Myoblasts. Erratum:[Molecules. 2022 May 31;27(11):3534. doi: 10.3390/molecules27113534. PMID: 35684584] Publication Status: Online-Only, [RefSeq, PubMed]; Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PB46;Q80W29;Q8BLA9;Q8BZL3;Q8BZW5", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q71B07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58465-1", "uniprot_id": "CTDSL_MOUSE", "mass": 31156.0, "length": 276, "protein_name": "CTD small phosphatase-like protein", "gene_name": "Ctdspl", "organism": "Mouse", "refseq_name": "CTD small phosphatase-like protein", "refseq_ac": "NP_598471", "gene_names_uniprotkb": "Ctdspl; Nif1; Nifl", "gene_names_refseq": "2810418J22Rik; Ctdspl; HYA22; SCP3", "protein_names_uniprotkb": "CTD small phosphatase-like protein; 3.1.3.16; CTDSP-like; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; SCP3; Small C-terminal domain phosphatase 3; Small CTD phosphatase 3", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein; CTDSP-like; NIF-like protein; NLI-interacting factor 1; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; nuclear LIM interactor-interacting factor 1; small C-terminal domain phosphatase 3; small CTD phosphatase 3", "tax_id": 10090, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:69274)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KL5", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D665-1", "uniprot_id": "D42E1_MOUSE", "mass": 43894.0, "length": 394, "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "Sdr42e1", "organism": "Mouse", "refseq_name": "short-chain dehydrogenase/reductase family 42E member 1", "refseq_ac": "NP_083001", "gene_names_uniprotkb": "Sdr42e1", "gene_names_refseq": "4632417N05Rik; Sdr42e1", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 42E member 1; 1.1.1.-", "protein_names_refseq": "short-chain dehydrogenase/reductase family 42E member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74032)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCV0", "ec_number_list": "", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIH7-1", "uniprot_id": "CYYR1_MOUSE", "mass": 18044.0, "length": 165, "protein_name": "Cysteine and tyrosine-rich protein 1", "gene_name": "Cyyr1", "organism": "Mouse", "refseq_name": "cysteine and tyrosine-rich protein 1 precursor", "refseq_ac": "NP_659102", "gene_names_uniprotkb": "Cyyr1", "gene_names_refseq": "Cyyr1", "protein_names_uniprotkb": "Cysteine and tyrosine-rich protein 1; Proline-rich domain-containing protein", "protein_names_refseq": "cysteine and tyrosine-rich protein 1 precursor; proline-rich domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:224405)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12036297;12062809;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499D9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VIH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CG15-1", "uniprot_id": "CTF8_MOUSE", "mass": 13228.0, "length": 121, "protein_name": "Chromosome transmission fidelity protein 8 homolog", "gene_name": "Chtf8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Chtf8; Ctf8", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 8 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:214987); (R-MMU-174411)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P0C6T0;Q8BHM2;Q8R5A5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0CG15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSU2-1", "uniprot_id": "CXL16_MOUSE", "mass": 26896.0, "length": 246, "protein_name": "C-X-C motif chemokine 16", "gene_name": "Cxcl16", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 16 precursor", "refseq_ac": "NP_075647", "gene_names_uniprotkb": "Cxcl16; Srpsox", "gene_names_refseq": "0910001K24Rik; CXCL16v1; CXCL16v2; Cxcl16; SR-PSOX; Zmynd15; b2b498Clo", "protein_names_uniprotkb": "C-X-C motif chemokine 16; SR-PSOX; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Small-inducible cytokine B16; Transmembrane chemokine CXCL16", "protein_names_refseq": "C-X-C motif chemokine 16 precursor; C-X-C motif chemokine 16; Cxc chemokine ligand 16; SR-PSOX/CXCL16; chemokine (C-X-C motif) ligand 16; scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; small-inducible cytokine B16; transmembrane chemokine CXCL16; zinc finger, MYND-type containing 15", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:66102); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11017100;11060282;14699018;20675388;21750661", "class_list": "", "function": "Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis., [UniProtKB, PubMed]; SR-PSOX/CXCL16 may be involved in CD8+ T cell recruitment through VLA-4 activation and stimulation of IFN-[gamma] production by CD8+ T cells during inflammatory valvular heart disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD70;Q5F2D5;Q8VE25;Q9EPB3", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity;GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0034612 response to tumor necrosis factor;GO:0071222 cellular response to lipopolysaccharide;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BSU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXI8-1", "uniprot_id": "CXXC4_MOUSE", "mass": 20978.0, "length": 198, "protein_name": "CXXC-type zinc finger protein 4", "gene_name": "Cxxc4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cxxc4; Idax", "gene_names_refseq": "", "protein_names_uniprotkb": "CXXC-type zinc finger protein 4; Inhibition of the Dvl and axin complex protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:319478)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11113207;21750661", "class_list": "", "function": "Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (PubMed:11113207). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding;GO:0008327 methyl-CpG binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NXI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35728-1", "uniprot_id": "CP4AE_MOUSE", "mass": 58720.0, "length": 507, "protein_name": "Cytochrome P450 4A14", "gene_name": "Cyp4a14", "organism": "Mouse", "refseq_name": "cytochrome P450 4A14", "refseq_ac": "NP_031848", "gene_names_uniprotkb": "Cyp4a14", "gene_names_refseq": "Cyp4a14", "protein_names_uniprotkb": "Cytochrome P450 4A14; CYPIVA14; Lauric acid hydroxylase", "protein_names_refseq": "CYPIVA14; cytochrome P450 4A14; cytochrome P450, 4a14; cytochrome P450-LA-omega 3; lauric acid hydroxylase; lauric acid omega-hydroxylase 3; long-chain fatty acid omega-monooxygenase", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:13119); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "17112342;28270609;28912346;29277328;30084848;34428180;37453647;37659685;9271096", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids (PubMed:17112342). May act as a major omega- and ommega-1 hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic acid (PubMed:17112342)., [UniProtKB, PubMed]; CYP4A14 may represent a useful target for the treatment of AngII-associated renal damage., [RefSeq, PubMed]; H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection., [RefSeq, PubMed]; Hypertension in Cyp4a14(-/-) male mice was accompanied by decreased renal perfusion and reduced glomerular filtration rates, [RefSeq, PubMed]; This study provides a link between CYP4A14 and NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced NASH. Erratum:[Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2315591120. doi: 10.1073/pnas.2315591120. PMID: 37824533], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A975;Q3UER2;Q5EBH0", "ec_number_list": "1.14.14.1;1.14.14.80;1.14.13.n7;1.14.14.79", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050544 arachidonate binding;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process;GO:0019369 arachidonate metabolic process;GO:0048252 lauric acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54983-1", "uniprot_id": "CRYM_MOUSE", "mass": 33523.0, "length": 313, "protein_name": "Ketimine reductase mu-crystallin", "gene_name": "Crym", "organism": "Mouse", "refseq_name": "ketimine reductase mu-crystallin", "refseq_ac": "NP_057878", "gene_names_uniprotkb": "Crym", "gene_names_refseq": "Crym", "protein_names_uniprotkb": "Ketimine reductase mu-crystallin; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase; 1.5.1.1; 1.5.1.25; NADP-regulated thyroid-hormone-binding protein; P2C/Pyr2C reductase", "protein_names_refseq": "1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase; NADP-regulated thyroid-hormone-binding protein; P2C/Pyr2C reductase; ketimine reductase mu-crystallin; mu-crystallin homolog; thiomorpholine-carboxylate dehydrogenase", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 40 (Disease Ontology:DOID:0110566)", "pathway": " (mmu:12971); (R-MMU-71064)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16740909;24467707;33300544;38418885", "class_list": "", "function": "Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (By similarity). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Crym-positive striatal astrocytes gate perseverative behaviour., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.25;1.5.1.1", "go_molecular_function": "GO:0047127 thiomorpholine-carboxylate dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0042562 hormone binding;GO:0070324 thyroid hormone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006839 mitochondrial transport;GO:0007605 sensory perception of sound;GO:0042403 thyroid hormone metabolic process;GO:0070327 thyroid hormone transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55071-1", "uniprot_id": "CP2BJ_MOUSE", "mass": 55997.0, "length": 492, "protein_name": "Cytochrome P450 2B19", "gene_name": "Cyp2b19", "organism": "Mouse", "refseq_name": "cytochrome P450 2B19", "refseq_ac": "NP_031840", "gene_names_uniprotkb": "Cyp2b19", "gene_names_refseq": "CYPIIB19; Cyp2b19", "protein_names_uniprotkb": "Cytochrome P450 2B19; 1.14.14.1; CYPIIB19", "protein_names_refseq": "cytochrome P450 2B19; cytochrome P450, 2b19", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13090)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12840027;15680914;22083726;30084848;9799616", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes., [RefSeq, PubMed]; This enzyme is a keratinocyte-specific arachidonic acid epoxygenase expressed in the granular cell layer of mouse epidermis., [RefSeq, PubMed]; We conclude that while mouse epidermis likely expresses multiple cytochrome P450 enzymes, existing evidence supports native CYP2B19 as being the major source of epidermal EET formation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQK1", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0008202 steroid metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88456-1", "uniprot_id": "CPNS1_MOUSE", "mass": 28406.0, "length": 268, "protein_name": "Calpain small subunit 1", "gene_name": "Capns1", "organism": "Mouse", "refseq_name": "calpain small subunit 1", "refseq_ac": "NP_033925", "gene_names_uniprotkb": "Capns1; Capn4", "gene_names_refseq": "Capa-4; Capa4; Capn4; Capns1; Cdps; Css1; D7Ertd146e", "protein_names_uniprotkb": "Calpain small subunit 1; CANP small subunit; CDPS; CSS1; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain regulatory subunit", "protein_names_refseq": "CANP small subunit; calcium-activated neutral proteinase small subunit; calcium-dependent protease small subunit 1; calpain 4; calpain regulatory subunit; calpain small subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12336); (R-MMU-1474228); (R-MMU-9856530); (R-MMU-9860927)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10825211;21750661;26495903;34678516;35729674;37660839;9774740", "class_list": "", "function": "Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype., [RefSeq, PubMed]; Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (PubMed:10825211)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IZW8;D3YW48;Q3V0X5;Q5BKQ2;Q8CEI2;Q8VEK4;Q9R1C5", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0110158 calpain complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88456-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02525-1", "uniprot_id": "CRBA1_MOUSE", "mass": 23401.0, "length": 198, "protein_name": "Beta-crystallin A1", "gene_name": "Cryba1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cryba1", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-crystallin A1; Beta-A1-crystallin", "protein_names_refseq": "", "tax_id": 10090, "disease": "age related macular degeneration 1 (Disease Ontology:DOID:0110014); cataract 10 multiple types (Disease Ontology:DOID:0110258); microphthalmia (Disease Ontology:DOID:10629); retinal detachment (Disease Ontology:DOID:5327); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "6835368;6896514", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006909 phagocytosis;GO:0007601 visual perception;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032007 negative regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CW70-1", "uniprot_id": "D19L2_MOUSE", "mass": 89882.0, "length": 773, "protein_name": "Probable C-mannosyltransferase DPY19L2", "gene_name": "Dpy19l2", "organism": "Mouse", "refseq_name": "probable C-mannosyltransferase DPY19L2", "refseq_ac": "NP_001159679", "gene_names_uniprotkb": "Dpy19l2", "gene_names_refseq": "4932443J21Rik; Dpy19l2; Gm18376", "protein_names_uniprotkb": "Probable C-mannosyltransferase DPY19L2; 2.4.1.-; Dpy-19-like protein 2; Protein dpy-19 homolog 2", "protein_names_refseq": "dpy-19-like protein 2; probable C-mannosyltransferase DPY19L2; protein dpy-19 homolog 2", "tax_id": 10090, "disease": "spermatogenic failure 9 (Disease Ontology:DOID:0111156)", "pathway": " (mmu:320752)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21397064;22764053;25775128;34471926", "class_list": "glycogene;glycosyltransferase", "function": "Absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina and the junction between the acroplaxome and the nuclear envelope in spermatids. Consequently, the acrosome and the manchette fail to be linked to the nucleus., [RefSeq, PubMed]; In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome. Erratum:[PLoS One. 2015 Apr 10;10(4):e0125452. doi: 10.1371/journal.pone.0125452. Nahed, Roland Abi [corrected to Abi Nahed, Roland]. PMID: 25860994] Publication Status: Online-Only, [RefSeq, PubMed]; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins., [UniProtKB, UniProtKB]; Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CW70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10889-1", "uniprot_id": "CXCL2_MOUSE", "mass": 10621.0, "length": 100, "protein_name": "C-X-C motif chemokine 2", "gene_name": "Cxcl2", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 2 precursor", "refseq_ac": "NP_033166", "gene_names_uniprotkb": "Cxcl2; Mip-2; Mip2; Scyb2", "gene_names_refseq": "CINC-2a; Cxcl2; GROb; Gro2; MIP-2a; MIP-2; Mgsa-b; Mip2; Scyb2; Scyb", "protein_names_uniprotkb": "C-X-C motif chemokine 2; MIP2; Macrophage inflammatory protein 2", "protein_names_refseq": "C-X-C motif chemokine 2 precursor; C-X-C motif chemokine 2; chemokine (C-X-C motif) ligand 2; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2", "tax_id": 10090, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); viral pneumonia (Disease Ontology:DOID:10533); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain edema (Disease Ontology:DOID:4724); pneumonia (Disease Ontology:DOID:552); periodontitis (Disease Ontology:DOID:824); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); hyperhomocysteinemia (Disease Ontology:DOID:9279); cholangitis (Disease Ontology:DOID:9446)", "pathway": " (mmu:20310); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "2201751;25428506;2643119;38758783;39135337;9622482", "class_list": "", "function": "Brain border-derived CXCL2[+] neutrophils drive NET formation and impair vascular reperfusion following ischemic stroke., [RefSeq, PubMed]; Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst., [UniProtKB]; Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010332 response to gamma radiation;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12791-1", "uniprot_id": "CP2BA_MOUSE", "mass": 56744.0, "length": 500, "protein_name": "Cytochrome P450 2B10", "gene_name": "Cyp2b10", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp2b10; Cyp2b-10; Cyp2b20", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2B10; 1.14.14.1; CYPIIB10; CYPIIB20; Cytochrome P450 2B20; Cytochrome P450 clone PF3/46; Cytochrome P450-16-alpha; P24; Testosterone 16-alpha hydroxylase", "protein_names_refseq": "", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); depressive disorder (Disease Ontology:DOID:1596); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-MMU-211935); (R-MMU-211945); (R-MMU-211981); (R-MMU-211999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;2779523;3219345;36210013;8831708", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62397", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14847-1", "uniprot_id": "CRP_MOUSE", "mass": 25360.0, "length": 225, "protein_name": "C-reactive protein", "gene_name": "Crp", "organism": "Mouse", "refseq_name": "C-reactive protein precursor", "refseq_ac": "NP_031794", "gene_names_uniprotkb": "Crp; Ptx1", "gene_names_refseq": "Crp", "protein_names_uniprotkb": "C-reactive protein", "protein_names_refseq": "C-reactive protein precursor; C-reactive protein, petaxin related", "tax_id": 10090, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); pelvic inflammatory disease (Disease Ontology:DOID:1003); bacterial infectious disease (Disease Ontology:DOID:104); interstitial nephritis (Disease Ontology:DOID:1063); renal hypertension (Disease Ontology:DOID:1073); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); heart disease (Disease Ontology:DOID:114); pyelonephritis (Disease Ontology:DOID:11400); hypertensive retinopathy (Disease Ontology:DOID:11561); familial hyperlipidemia (Disease Ontology:DOID:1168); iron deficiency anemia (Disease Ontology:DOID:11758); vestibular neuronitis (Disease Ontology:DOID:12683); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); aspergillosis (Disease Ontology:DOID:13564); pharyngoconjunctival fever (Disease Ontology:DOID:13801); interstitial cystitis (Disease Ontology:DOID:13949); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); mouth disease (Disease Ontology:DOID:403); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); acute stress disorder (Disease Ontology:DOID:6088); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); otitis externa (Disease Ontology:DOID:9463); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12944); (R-MMU-173623)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2310378;3190681;36946778;37844994;38308931", "class_list": "", "function": "C-reactive protein impairs immune response of CD8[+] T cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma. Erratum:[J Immunother Cancer. 2023 Dec 14;11(12):e007593corr1. doi: 10.1136/jitc-2023-007593corr1. PMID: 38101865], [RefSeq, PubMed]; Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells., [UniProtKB]; Innate Immune Zonation in the Liver: NF-kappaB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific., [RefSeq, PubMed]; The cAMP receptor protein gene contributes to growth, stress resistance, and colonization of Actinobacillus pleuropneumoniae., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 85, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PZ20", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0005509 calcium ion binding;GO:0015485 cholesterol binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030426 growth cone;GO:0030175 filopodium", "go_biological_process": "GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P14847-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28229-1", "uniprot_id": "CXG1_MOUSE", "mass": 45666.0, "length": 396, "protein_name": "Gap junction gamma-1 protein", "gene_name": "Gjc1", "organism": "Mouse", "refseq_name": "gap junction gamma-1 protein", "refseq_ac": "NP_001152854", "gene_names_uniprotkb": "Gjc1; Cxn-45; Gja7", "gene_names_refseq": "C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7; Gja7; Gjc1", "protein_names_uniprotkb": "Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein", "protein_names_refseq": "connexin q; connexin-45; gap junction alpha-7 protein; gap junction gamma-1 protein; gap junction membrane channel protein alpha 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:14615); (R-MMU-112303); (R-MMU-190861)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12168774;1322300;19864490;37828378;39074069", "class_list": "", "function": "Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005921 gap junction", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0045087 innate immune response;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28229-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28230-1", "uniprot_id": "CXB1_MOUSE", "mass": 32004.0, "length": 283, "protein_name": "Gap junction beta-1 protein", "gene_name": "Gjb1", "organism": "Mouse", "refseq_name": "gap junction beta-1 protein", "refseq_ac": "NP_001289425", "gene_names_uniprotkb": "Gjb1; Cxn-32", "gene_names_refseq": "Cnx32; Cx32; Cxng; Gjb1; connexin-32", "protein_names_uniprotkb": "Gap junction beta-1 protein; Connexin-32; Cx32", "protein_names_refseq": "connexin 32; connexin g; connexin-43; gap junction beta-1 protein; gap junction membrane channel protein beta 1", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease X-linked dominant 1 (Disease Ontology:DOID:0110209); extrahepatic cholestasis (Disease Ontology:DOID:13619); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:14618); (R-MMU-190704)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12843301;1322820;18630941;19864490;2060697;30084848;34428180;37507007;38347637", "class_list": "", "function": "Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; This gene is a member of the gap junction protein (connexin) family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of ions and small molecules between cells. Mutations in a similar gene in human cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016328 lateral plasma membrane;GO:0005921 gap junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0015868 purine ribonucleotide transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P28230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28231-1", "uniprot_id": "CXB3_MOUSE", "mass": 30902.0, "length": 270, "protein_name": "Gap junction beta-3 protein", "gene_name": "Gjb3", "organism": "Mouse", "refseq_name": "gap junction beta-3 protein", "refseq_ac": "NP_001153484", "gene_names_uniprotkb": "Gjb3; Cxn-31", "gene_names_refseq": "Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3; Gjb3", "protein_names_uniprotkb": "Gap junction beta-3 protein; Connexin-31; Cx31", "protein_names_refseq": "connexin c; connexin-31; gap junction beta-3 protein; gap junction membrane channel protein beta 3", "tax_id": 10090, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal dominant nonsyndromic deafness 2A (Disease Ontology:DOID:0110558); autosomal dominant nonsyndromic deafness 2B (Disease Ontology:DOID:0110559); erythrokeratodermia variabilis et progressiva 1 (Disease Ontology:DOID:0111195)", "pathway": " (mmu:14620); (R-MMU-190861)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1322300;19864490;25428506;30084848;33066499;34428180;38956497", "class_list": "", "function": "Comparative Analysis of Cx31 and Cx43 in Differentiation-Competent Rodent Keratinocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Impairment of alpha-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion. Publication Status: Online-Only, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0030054 cell junction;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28236-1", "uniprot_id": "CXA8_MOUSE", "mass": 49598.0, "length": 440, "protein_name": "Gap junction alpha-8 protein", "gene_name": "Gja8", "organism": "Mouse", "refseq_name": "gap junction alpha-8 protein", "refseq_ac": "NP_032149", "gene_names_uniprotkb": "Gja8", "gene_names_refseq": "Aey5; Cnx50; Cx50; Cxnl; Gja8; Lop10; dcm", "protein_names_uniprotkb": "Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70", "protein_names_refseq": "alpha 8 connexin; connexin l; connexin-50; gap junction alpha-8 protein; gap junction membrane channel protein alpha 8; lens fiber protein MP70; lens opacity 10", "tax_id": 10090, "disease": "cataract 1 multiple types (Disease Ontology:DOID:0110231); microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:14616); (R-MMU-190861)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1325220;35820727;36139360", "class_list": "", "function": "Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of eye lens gap junctions (PubMed:1325220). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:1325220)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye;GO:1990349 gap junction-mediated intercellular transport;GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35173-1", "uniprot_id": "CYT3_MOUSE", "mass": 11640.0, "length": 103, "protein_name": "Stefin-3", "gene_name": "Stfa3", "organism": "Mouse", "refseq_name": "stefin-3", "refseq_ac": "NP_079564", "gene_names_uniprotkb": "Stfa3; Stf-3; Stf3", "gene_names_refseq": "Stf3; Stfa3", "protein_names_uniprotkb": "Stefin-3", "protein_names_refseq": "stefin-3", "tax_id": 10090, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523)", "pathway": " (mmu:20863)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16143425;8468045", "class_list": "", "function": "Stefin A3 is involved in infection and inflammation in primary cultured glial cells., [RefSeq, PubMed]; This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540I0", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001533 cornified envelope", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0018149 peptide cross-linking;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35175-1", "uniprot_id": "CYT1_MOUSE", "mass": 11007.0, "length": 97, "protein_name": "Stefin-1", "gene_name": "Stfa1", "organism": "Mouse", "refseq_name": "stefin-1", "refseq_ac": "NP_001076012", "gene_names_uniprotkb": "Stfa1; Stf-1; Stf1", "gene_names_refseq": "Stefin-3; Stf-3; Stf1; Stf3; Stfa1; Stfa3", "protein_names_uniprotkb": "Stefin-1", "protein_names_refseq": "stefin-1", "tax_id": 10090, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523)", "pathway": " (mmu:20861)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21458245;21750661;8468045", "class_list": "", "function": "In non-lesional HPV8-CER transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8, [RefSeq, PubMed]; This is an intracellular thiol proteinase inhibitor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004866 endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001533 cornified envelope", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0018149 peptide cross-linking;GO:0010951 negative regulation of endopeptidase activity;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43024-1", "uniprot_id": "CX6A1_MOUSE", "mass": 12352.0, "length": 111, "protein_name": "Cytochrome c oxidase subunit 6A1, mitochondrial", "gene_name": "Cox6a1", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 6A1, mitochondrial", "refseq_ac": "NP_031774", "gene_names_uniprotkb": "Cox6a1; Cox6al", "gene_names_refseq": "Cox6a1; VIaL", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A1, mitochondrial; Cytochrome c oxidase polypeptide VIa-liver", "protein_names_refseq": "cytochrome c oxidase polypeptide VIa-liver; cytochrome c oxidase subunit 6A1, mitochondrial; cytochrome c oxidase subunit VIa polypeptide 1; subunit VIaL (liver-type)", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease recessive intermediate D (Disease Ontology:DOID:0110203); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:12861); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10657640;21913724;22645316;25152455;25428506;26495903;28011936;30084848;31219806;32152506;34428180;35984892;37828378;7873616", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043209 myelin sheath;GO:0097228 sperm principal piece", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47941-1", "uniprot_id": "CRKL_MOUSE", "mass": 33830.0, "length": 303, "protein_name": "Crk-like protein", "gene_name": "Crkl", "organism": "Mouse", "refseq_name": "crk-like protein isoform 2", "refseq_ac": "NP_001264160", "gene_names_uniprotkb": "Crkl; Crkol", "gene_names_refseq": "1110025F07Rik; Crkl; Crkol; snoop", "protein_names_uniprotkb": "Crk-like protein", "protein_names_refseq": "crk-like protein isoform 2; crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog-like", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung carcinoma (Disease Ontology:DOID:3905); skin cancer (Disease Ontology:DOID:4159); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:12929); (R-MMU-170968); (R-MMU-186763); (R-MMU-8875555); (R-MMU-8875656); (R-MMU-9027284); (R-MMU-912631)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "11031258;11242111;15345747;18034455;21540332;21750661;26495903;28011936;31219806;34203471;34428180;36210013;37702066;37828378;7478571;9053848", "class_list": "", "function": "Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development., [RefSeq, PubMed]; Crkol is essential for cranial and cardiac neural crest development. The chromosomal location of the human CRKL gene (22q11.21) and the phenotype of Crkol mutant mice suggest that defects in CRKL-mediated pathways underlie DiGeorge syndrome., [RefSeq, PubMed]; May mediate the transduction of intracellular signals., [UniProtKB]; This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In certain mouse genetic backgrounds this protein is essential for embryonic development. It is important for neural crest cell differentiation and survival and is proposed to play an important role in transducing the oncogenic signal of Bcr/Abl. Deletion of this gene in mouse mimics the phenotype of DiGeorge/velocardiofacial syndrome in human. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ18;Q8BGC5", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0035591 signaling adaptor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0098890 extrinsic component of postsynaptic membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:1904888 cranial skeletal system development;GO:0086100 endothelin receptor signaling pathway;GO:0060017 parathyroid gland development;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56593-1", "uniprot_id": "CP2AC_MOUSE", "mass": 56179.0, "length": 492, "protein_name": "Cytochrome P450 2A12", "gene_name": "Cyp2a12", "organism": "Mouse", "refseq_name": "cytochrome P450 2A12", "refseq_ac": "NP_598418", "gene_names_uniprotkb": "Cyp2a12", "gene_names_refseq": "Cyp2a12", "protein_names_uniprotkb": "Cytochrome P450 2A12; 1.14.14.1; CYPIIA12; Steroid hormones 7-alpha-hydroxylase; Testosterone 7-alpha-hydroxylase", "protein_names_refseq": "CYPIIA12; cytochrome P450 2A12; cytochrome P450, 2a12; steroid hormones 7-alpha-hydroxylase; testosterone 7-alpha-hydroxylase", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); warfarin resistance (Disease Ontology:DOID:0080665); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (mmu:13085); (R-MMU-211935); (R-MMU-211981); (R-MMU-211999); (R-MMU-5423646)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "30084848;31645370;34428180;37453647;8484736", "class_list": "", "function": "Highly active in the 7-alpha-hydroxylation of testosterone., [UniProtKB]; Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCW9", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0009804 coumarin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56654-1", "uniprot_id": "CP237_MOUSE", "mass": 55606.0, "length": 490, "protein_name": "Cytochrome P450 2C37", "gene_name": "Cyp2c37", "organism": "Mouse", "refseq_name": "cytochrome P450 2C37 precursor", "refseq_ac": "NP_034131", "gene_names_uniprotkb": "Cyp2c37", "gene_names_refseq": "Cyp2c37", "protein_names_uniprotkb": "Cytochrome P450 2C37; 1.14.14.1; CYPIIC37", "protein_names_refseq": "CYPIIC37; cytochrome P450 2C37 precursor; cytochrome P450 2C37; cytochrome P450, 2c37", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:13096)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;36210013;9721182", "class_list": "", "function": "A cytochrome P450 monooxygenase that metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to primarily produce 12-hydroxyeicosatetraenoic acid (12-HETE). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKN4", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56654-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56655-1", "uniprot_id": "CP238_MOUSE", "mass": 56229.0, "length": 490, "protein_name": "Cytochrome P450 2C38", "gene_name": "Cyp2c38", "organism": "Mouse", "refseq_name": "cytochrome P450 2C38 isoform 1 precursor", "refseq_ac": "NP_034132", "gene_names_uniprotkb": "Cyp2c38", "gene_names_refseq": "Cyp2c38", "protein_names_uniprotkb": "Cytochrome P450 2C38; 1.14.14.1; CYPIIC38", "protein_names_refseq": "CYPIIC38; cytochrome P450 2C38 isoform 1 precursor; cytochrome P450 2C38; cytochrome P450, 2c38", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:13097)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19358898;34428180;9721182", "class_list": "", "function": "A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 11,12-epoxyeicosatrienoic acid (11,12-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase)., [UniProtKB, PubMed]; By comparison of active site architectures between CYP2C38 and CYP2C39, the possible reasons affecting their substrate binding were proposed, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWV4;F8VPK7", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56656-1", "uniprot_id": "CP239_MOUSE", "mass": 55827.0, "length": 490, "protein_name": "Cytochrome P450 2C39", "gene_name": "Cyp2c39", "organism": "Mouse", "refseq_name": "cytochrome P450 2C39 isoform 1 precursor", "refseq_ac": "NP_034133", "gene_names_uniprotkb": "Cyp2c39", "gene_names_refseq": "CYPIIC39; Cyp2c39", "protein_names_uniprotkb": "Cytochrome P450 2C39; 1.14.14.1; CYPIIC39", "protein_names_refseq": "cytochrome P450 2C39 isoform 1 precursor; cytochrome P450 2C39; cytochrome P450, 2c39", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:13098)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14623888;19358898;25428506;28011936;34428180;36210013;9721182", "class_list": "", "function": "A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 and 14,15 double bonds of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 11,12- and 14,15-epoxyeicosatrienoic acids (11,12- and 14,15-EET) regioisomers. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase)., [UniProtKB, PubMed]; By comparison of active site architectures between CYP2C38 and CYP2C39, the possible reasons affecting their substrate binding were proposed, [RefSeq, PubMed]; CYP2C39 is a novel retinoic acid 4-hydroxylase, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EIA6;G5E854", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62696-1", "uniprot_id": "CRBB2_MOUSE", "mass": 23381.0, "length": 205, "protein_name": "Beta-crystallin B2", "gene_name": "Crybb2", "organism": "Mouse", "refseq_name": "beta-crystallin B2", "refseq_ac": "NP_031799", "gene_names_uniprotkb": "Crybb2", "gene_names_refseq": "Cryb-2; Crybb2", "protein_names_uniprotkb": "Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp", "protein_names_refseq": "beta-crystallin B2; beta-crystallin Bp", "tax_id": 10090, "disease": "cataract 3 multiple types (Disease Ontology:DOID:0110269); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:12961)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;1707874;29864422;30291584;37103007", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Endoplasmic Reticulum Stress and the Lysosomal Pathway Play Crucial Roles in the Progression of betaB2-Crystallin Mutation-Induced Congenital Cataracts in Mice., [RefSeq, PubMed]; Mutated Crybb2 is implicated in the development of schizophrenia., [RefSeq, PubMed]; This gene is a member of the beta-crystallin family. Beta crystallins, along with alpha and gamma crystallins, are the major proteins found in the eye lens. These proteins maintain the refractive index of the lens whilst also maintaining its transparency. Since lens central fiber cells lose their nuclei during development, crystallins are made and then retained throughout life, making them extremely stable proteins. Beta and gamma crystallins are considered be a superfamily and have a similar domain architecture, including four Greek Key motifs. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. The protein encoded by this gene may have Ca2+-binding activity and could be associated with potential functions in the hippocampus and in sperm. Targeted knockout of this gene in mouse induces age-related cataract. A chain-terminating mutation in a similar gene in human was found to cause type 2 cerulean cataracts. [provided by RefSeq, Feb 2015]., [RefSeq]; Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P19942;P26775;Q0VGT6", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62696-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02739-1", "uniprot_id": "CXB5_MOUSE", "mass": 31195.0, "length": 271, "protein_name": "Gap junction beta-5 protein", "gene_name": "Gjb5", "organism": "Mouse", "refseq_name": "gap junction beta-5 protein", "refseq_ac": "NP_034421", "gene_names_uniprotkb": "Gjb5; Cxn-31.1", "gene_names_refseq": "Cnx31.1; Cx31.1; Cxna; Gjb-5; Gjb5", "protein_names_uniprotkb": "Gap junction beta-5 protein; Connexin-31.1; Cx31.1", "protein_names_refseq": "connexin a; connexin-31.1; gap junction beta-5 protein; gap junction membrane channel protein beta 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:14622); (R-MMU-190861)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1512260;24866916;25428506", "class_list": "", "function": "Findings show delayed differentiation of connexin31.1 (Gjb5)-deficient trophoblast stem cell., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0060708 spongiotrophoblast differentiation;GO:0060707 trophoblast giant cell differentiation;GO:0060713 labyrinthine layer morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AM7-1", "uniprot_id": "HAPR1_MOUSE", "mass": 30940.0, "length": 275, "protein_name": "HUWE1-associated protein modifying stress responses", "gene_name": "Hapstr1", "organism": "Mouse", "refseq_name": "HUWE1-associated protein modifying stress responses", "refseq_ac": "NP_001074869", "gene_names_uniprotkb": "Hapstr1; 1810013L24Rik", "gene_names_refseq": "1110017P05Rik; 1810013L24Rik; 3010002C02Rik; Gm19906; Hapstr1; Tapr1", "protein_names_uniprotkb": "HUWE1-associated protein modifying stress responses", "protein_names_refseq": "HUWE1-associated protein modifying stress responses; UPF0472 protein C16orf72 homolog; telomere attrition and p53 response 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69053)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38453366", "class_list": "", "function": "Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1., [UniProtKB, UniProtKB]; Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D905", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0080135 regulation of cellular response to stress;GO:1901797 negative regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14AM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UYV8-1", "uniprot_id": "DAAF3_MOUSE", "mass": 64613.0, "length": 586, "protein_name": "Dynein axonemal assembly factor 3", "gene_name": "Dnaaf3", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 3", "refseq_ac": "NP_001028720", "gene_names_uniprotkb": "Dnaaf3", "gene_names_refseq": "6030429G01Rik; Dnaaf3; b2b1739Clo", "protein_names_uniprotkb": "Dynein axonemal assembly factor 3", "protein_names_refseq": "UPF0470 protein C19orf51 homolog; dynein assembly factor 3, axonemal; dynein axonemal assembly factor 3", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 2 (Disease Ontology:DOID:0110626)", "pathway": " (mmu:436022)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX55", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0030324 lung development;GO:0000902 cell morphogenesis;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UYV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0P1-1", "uniprot_id": "CPXCR_MOUSE", "mass": 37706.0, "length": 322, "protein_name": "CPX chromosomal region candidate gene 1 protein homolog", "gene_name": "Cpxcr1", "organism": "Mouse", "refseq_name": "CPX chromosomal region candidate gene 1 protein homolog", "refseq_ac": "NP_001028643", "gene_names_uniprotkb": "Cpxcr1; Gm1143", "gene_names_refseq": "Cpxcr1; Gm1143", "protein_names_uniprotkb": "CPX chromosomal region candidate gene 1 protein homolog", "protein_names_refseq": "CPX chromosomal region candidate gene 1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:382239)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BEE6;B2RW29", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V0P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62426-1", "uniprot_id": "CYTB_MOUSE", "mass": 11046.0, "length": 98, "protein_name": "Cystatin-B", "gene_name": "Cstb", "organism": "Mouse", "refseq_name": "cystatin-B", "refseq_ac": "NP_031819", "gene_names_uniprotkb": "Cstb; Cst6; Stfb", "gene_names_refseq": "Cstb; Stfb", "protein_names_uniprotkb": "Cystatin-B; Stefin-B", "protein_names_refseq": "cystatin-B; stefin-B", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 1A (Disease Ontology:DOID:0111452); Unverricht-Lundborg syndrome (Disease Ontology:DOID:3535)", "pathway": " (mmu:13014); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "22645316;25153642;28135057;28528544;31219806;37453647;37507081;8938434", "class_list": "", "function": "This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAW2", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004866 endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:1990000 amyloid fibril formation;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64459-1", "uniprot_id": "CP3AB_MOUSE", "mass": 57855.0, "length": 504, "protein_name": "Cytochrome P450 3A11", "gene_name": "Cyp3a11", "organism": "Mouse", "refseq_name": "cytochrome P450 3A11", "refseq_ac": "NP_031844", "gene_names_uniprotkb": "Cyp3a11; Cyp3a-11", "gene_names_refseq": "Cyp3a11; Cyp3a; IIIAm1; Pcn", "protein_names_uniprotkb": "Cytochrome P450 3A11; 1.14.14.1; CYPIIIA11; Cytochrome P-450IIIAM1; Cytochrome P-450UT", "protein_names_refseq": "CYPIIIA11; cytochrome P-450IIIAM1; cytochrome P-450UT; cytochrome P450 3A11; cytochrome P450, steroid inducible 3a11; steroid inducible", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13112); (R-MMU-211945); (R-MMU-211958); (R-MMU-211981); (R-MMU-5423646); (R-MMU-9027307); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "1339292;2402224;30084848;31633069;34428180;37258238", "class_list": "", "function": "Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation., [UniProtKB]; Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby impacting drug detoxification as a function of daily time. Publication Status: Online-Only, [RefSeq, PubMed]; Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0002933 lipid hydroxylation;GO:0008210 estrogen metabolic process;GO:0009617 response to bacterium;GO:0042573 retinoic acid metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64505-1", "uniprot_id": "CP7A1_MOUSE", "mass": 57262.0, "length": 503, "protein_name": "Cytochrome P450 7A1", "gene_name": "Cyp7a1", "organism": "Mouse", "refseq_name": "cytochrome P450 7A1", "refseq_ac": "NP_031850", "gene_names_uniprotkb": "Cyp7a1; Cyp7", "gene_names_refseq": "CYPVIIc; CYPVII; Cyp7a1", "protein_names_uniprotkb": "Cytochrome P450 7A1; 1.14.14.23; 1.14.14.26; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase", "protein_names_refseq": "24-hydroxycholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cytochrome P450, 7a1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619)", "pathway": " (mmu:13122); (R-MMU-192105); (R-MMU-193368); (R-MMU-193807); (R-MMU-211976)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "14522988;17636037;34428180;35287950;35605662;36868469;8088795", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity)., [UniProtKB, PubMed, UniProtKB]; MiR-194 Up-Regulates Cholesterol 7 Alpha-Hydroxylase Expression via beta-Catenin Signaling and Aggravates Cholestatic Liver Diseases., [RefSeq, PubMed]; MicroRNA-185 modulates CYP7A1 mediated cholesterol-bile acid metabolism through post-transcriptional and post-translational regulation of FoxO1., [RefSeq, PubMed]; Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFR7", "ec_number_list": "2.3.1.48;1.14.14.26;1.14.14.29;1.14.14.23", "go_molecular_function": "GO:0008123 cholesterol 7-alpha-monooxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0033782 24S-hydroxycholesterol 7-alpha-hydroxylase activity", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0070859 positive regulation of bile acid biosynthetic process;GO:0006699 bile acid biosynthetic process;GO:0045471 response to ethanol;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q64505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1H1-1", "uniprot_id": "CYAC3_MOUSE", "mass": 27086.0, "length": 242, "protein_name": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "gene_name": "Cyb561a3", "organism": "Mouse", "refseq_name": "lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1", "refseq_ac": "NP_001268993", "gene_names_uniprotkb": "Cyb561a3; Cybasc3", "gene_names_refseq": "2310004G04Rik; Cyb561a3; Cybasc3; Lcytb", "protein_names_uniprotkb": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; 7.2.1.3; Cytochrome b ascorbate-dependent protein 3; Cytochrome b561 family member A3; LCytb; Lysosomal cytochrome b", "protein_names_refseq": "cytochrome b ascorbate-dependent protein 3; lysosomal cytochrome b; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:225912)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16911521;16996694;21750661", "class_list": "", "function": "Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome (PubMed:16911521). Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters (Probable). It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVE2;Q3V3G2", "ec_number_list": "7.2.1.3", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P1H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAC3-1", "uniprot_id": "DCA13_MOUSE", "mass": 51456.0, "length": 445, "protein_name": "DDB1- and CUL4-associated factor 13", "gene_name": "Dcaf13", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 13 isoform 1", "refseq_ac": "NP_941008", "gene_names_uniprotkb": "Dcaf13; Gm83; Wdsof1", "gene_names_refseq": "Dcaf13; Gm83; Wdsof1", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 13; WD repeat and SOF domain-containing protein 1", "protein_names_refseq": "DDB1- and CUL4-associated factor 13 isoform 1; WD repeat and SOF domain-containing protein 1; WD repeats and SOF domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223499); (R-MMU-6791226); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "21952136;25428506;25605945;30084848;30111536;30283081;30779550;31000741;31492966;34428180;35178836;35820727;35932979", "class_list": "", "function": "CRL4-DCAF13-mediated SUV39H1 degradation is an essential step for progressive genome reprogramming during preimplantation embryonic development., [RefSeq, PubMed]; Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081)., [UniProtKB, UniProtKB, PubMed]; Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (PubMed:31000741). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (PubMed:35178836)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The DCAF13-dependent PTEN degradation mechanism fits in as a missing link between CRL4 ubiquitin E3 ligase and PI3K pathway, both of which are crucial for translational activation during oocyte germinal vesicle -metaphase of meiosis II transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPL0", "ec_number_list": "", "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006364 rRNA processing;GO:0046697 decidualization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6PAC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PFH3-1", "uniprot_id": "DCA15_MOUSE", "mass": 66643.0, "length": 600, "protein_name": "DDB1- and CUL4-associated factor 15", "gene_name": "Dcaf15", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 15 isoform 1", "refseq_ac": "NP_766090", "gene_names_uniprotkb": "Dcaf15", "gene_names_refseq": "6720484B16; Dcaf15", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 15", "protein_names_refseq": "DDB1- and CUL4-associated factor 15 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212123)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;30779550;34428180", "class_list": "", "function": "Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U305;Q8BMB2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0002376 immune system process;GO:0032814 regulation of natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PFH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6W5C0-1", "uniprot_id": "CXCL3_MOUSE", "mass": 10686.0, "length": 100, "protein_name": "C-X-C motif chemokine 3", "gene_name": "Cxcl3", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 3 precursor", "refseq_ac": "NP_976065", "gene_names_uniprotkb": "Cxcl3; Dcip1; Gm1960", "gene_names_refseq": "Cxcl3; Dcip1; Gm1960", "protein_names_uniprotkb": "C-X-C motif chemokine 3; Dendritic cell inflammatory protein 1", "protein_names_refseq": "C-X-C motif chemokine 3 precursor; C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; dendritic cell inflammatory protein 1", "tax_id": 10090, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); common cold (Disease Ontology:DOID:10459); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bacterial pneumonia (Disease Ontology:DOID:874); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:330122); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14764687;23115191;32948685;37073091;38617547", "class_list": "", "function": "A Critical Role for the CXCL3/CXCL5/CXCR2 Neutrophilic Chemotactic Axis in the Regulation of Type 2 Responses in a Model of Rhinoviral-Induced Asthma Exacerbation., [RefSeq, PubMed]; CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway., [RefSeq, PubMed]; DCIP-1 interacts with chemokine CXCR2 and mediates human neutrophil chemotaxis, consistent with its role during the early proinflammatory phase of dendritic cell maturation., [RefSeq, PubMed]; Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion., [UniProtKB, PubMed, UniProtKB]; TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-kappaB/CXCL3 axis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]., [RefSeq]; Tis21 induces migration of cerebellar granule neuron precursor cells through Cxcl3, which may represent a novel target for medulloblastoma therapy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNK9", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0071222 cellular response to lipopolysaccharide;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6W5C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6X893-1", "uniprot_id": "CTL1_MOUSE", "mass": 73067.0, "length": 653, "protein_name": "Choline transporter-like protein 1", "gene_name": "Slc44a1", "organism": "Mouse", "refseq_name": "choline transporter-like protein 1 isoform A", "refseq_ac": "NP_598652", "gene_names_uniprotkb": "Slc44a1; Cd92; Cdw92; Ctl1", "gene_names_refseq": "2210409B22Rik; 4833416H08Rik; CHTL1; CTL1; Cdw92; Slc44a1", "protein_names_uniprotkb": "Choline transporter-like protein 1; Solute carrier family 44 member 1", "protein_names_refseq": "CDW92 antigen; choline transporter-like protein 1 isoform A; choline transporter-like protein 1", "tax_id": 10090, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:100434); (R-MMU-1483191); (R-MMU-6798163); (R-MMU-9958517)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15474312;19357133;21750661;30776907;30899004;34428180", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter (PubMed:15474312, PubMed:19357133). Also acts as a high-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (By similarity). Involved in membrane synthesis and myelin production (PubMed:15474312, PubMed:19357133)., [UniProtKB, PubMed, PubMed, UniProtKB]; SLC44A1 acts as a choline transporter both in the plasma membrane and in the mitochondria. Novel aspects of choline transport regulation in the muscle, nervous system, and cancer are reviewed. Review. Review article, [RefSeq, PubMed]; SLC44A1 mRNA and protein expression were down-regulated during choline deficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14DK0;Q6X894;Q8R0Y4;Q91Z29", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6X893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPS2-1", "uniprot_id": "CRNS1_MOUSE", "mass": 89281.0, "length": 827, "protein_name": "Carnosine synthase 1", "gene_name": "Carns1", "organism": "Mouse", "refseq_name": "carnosine synthase 1 isoform 2", "refseq_ac": "NP_001390976", "gene_names_uniprotkb": "Carns1; Atpgd1; Kiaa1394", "gene_names_refseq": "Atpgd1; Carns1; mKIAA1394", "protein_names_uniprotkb": "Carnosine synthase 1; 6.3.2.11; ATP-grasp domain-containing protein 1", "protein_names_refseq": "ATP-grasp domain containing 1; ATP-grasp domain-containing protein 1; carnosine synthase 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107239); (R-MMU-70921)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20097752;21750661;25428506;30084848;33040025", "class_list": "", "function": "Carnosine synthase deficiency is compatible with normal skeletal muscle and olfactory function but causes reduced olfactory sensitivity in aging mice., [RefSeq, PubMed]; Carnosine synthase is identified as ATP-grasp domain-containing protein 1, [RefSeq, PubMed]; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIK7;Q8VE56", "ec_number_list": "6.3.2.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0047730 carnosine synthase activity;GO:0102102 homocarnosine synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0035499 carnosine biosynthetic process;GO:1901652 response to peptide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6ZPS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76LW6-1", "uniprot_id": "DAND5_MOUSE", "mass": 19772.0, "length": 185, "protein_name": "DAN domain family member 5", "gene_name": "Dand5", "organism": "Mouse", "refseq_name": "DAN domain family member 5 precursor", "refseq_ac": "NP_957679", "gene_names_uniprotkb": "Dand5; Cerl2; Coco; Sp1", "gene_names_refseq": "Cerl-2; Cerl2; Cerr2; Dand5; Dte; GREM3; coco", "protein_names_uniprotkb": "DAN domain family member 5; Cerberus-like protein 2; Cerl-2", "protein_names_refseq": "DAN domain family member 5 precursor; DAN domain family, member 5; cerberus-like protein 2; dante", "tax_id": 10090, "disease": "visceral heterotaxy 13 (Disease Ontology:DOID:0051027)", "pathway": " (mmu:23863)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15466485;25033293;29125738;33587337;34210974;34260942;34531379", "class_list": "", "function": "Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (PubMed:15466485). Antagonist of BMP4 signaling (PubMed:15466485). Antagonist of TGF-beta signaling (By similarity). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (PubMed:25033293). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation (PubMed:33587337). Once internalized by endothelial cells, may alter their redox and glycolytic balance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038100 nodal binding;GO:0016015 morphogen activity;GO:0140311 protein sequestering activity;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:1900108 negative regulation of nodal signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0003281 ventricular septum development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q76LW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN08-1", "uniprot_id": "DACT2_MOUSE", "mass": 81668.0, "length": 757, "protein_name": "Dapper homolog 2", "gene_name": "Dact2", "organism": "Mouse", "refseq_name": "dapper homolog 2", "refseq_ac": "NP_766414", "gene_names_uniprotkb": "Dact2; Dpr2; Frd2", "gene_names_refseq": "2900084M21Rik; A630024E20; Dact2; Dpr2; Frd2; dapper2", "protein_names_uniprotkb": "Dapper homolog 2; Dapper antagonist of catenin 2; mDpr2", "protein_names_refseq": "dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper homolog 2; dapper, antagonist of beta-catenin, homolog 2; mDpr2", "tax_id": 10090, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); bile duct carcinoma (Disease Ontology:DOID:4897); pancreatic carcinoma (Disease Ontology:DOID:4905)", "pathway": " (mmu:240025)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16881060;17197390;18716284;20685821;21718540;21750661;29199082;37603122", "class_list": "", "function": "Dact2 expression is most prominent during organogenesis of the thymus, kidneys, and salivary glands, with much lower levels in the somites and in the developing CNS., [RefSeq, PubMed]; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling., [UniProtKB, PubMed, PubMed, PubMed]; Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis., [RefSeq, PubMed]; Our findings provide a novel DACT2 demethylating stimulator to verify and expand previously established link between DACT2 and colorectal cancer (CRC), suggesting DACT2 demethylation is strongly correlated with CRC prognosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDF4;Q8BHZ7", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0008134 transcription factor binding;GO:0008013 beta-catenin binding;GO:0051018 protein kinase A binding;GO:0070097 delta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0007162 negative regulation of cell adhesion;GO:0043588 skin development;GO:0072061 inner medullary collecting duct development;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TN08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80U19-1", "uniprot_id": "DAAM2_MOUSE", "mass": 128370.0, "length": 1115, "protein_name": "Disheveled-associated activator of morphogenesis 2", "gene_name": "Daam2", "organism": "Mouse", "refseq_name": "disheveled-associated activator of morphogenesis 2 isoform 1", "refseq_ac": "NP_001008232", "gene_names_uniprotkb": "Daam2; Kiaa0381", "gene_names_refseq": "2310016D11Rik; Daam2", "protein_names_uniprotkb": "Disheveled-associated activator of morphogenesis 2", "protein_names_refseq": "disheveled-associated activator of morphogenesis 2 isoform 1; disheveled-associated activator of morphogenesis 2", "tax_id": 10090, "disease": "nephrotic syndrome type 24 (Disease Ontology:DOID:0061194)", "pathway": " (mmu:76441)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15464228;15533824;22227309;22299025;24091014;25754822;26526197;33300544;34428180;35820727", "class_list": "", "function": "Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development., [RefSeq, PubMed]; Involved in pivotal steps in neuronal cell differentiation and movement, [RefSeq, PubMed]; Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (PubMed:26526197). Is a regulator of actin nucleation and elongation, filopodia formation and podocyte migration (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNU9;Q6TAB7;Q810J5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80U19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W99-1", "uniprot_id": "CTSR3_MOUSE", "mass": 45486.0, "length": 395, "protein_name": "Cation channel sperm-associated protein 3", "gene_name": "Catsper3", "organism": "Mouse", "refseq_name": "cation channel sperm-associated protein 3 isoform 1", "refseq_ac": "NP_001239416", "gene_names_uniprotkb": "Catsper3", "gene_names_refseq": "4921522D01Rik; CACRC; Catsper3", "protein_names_uniprotkb": "Cation channel sperm-associated protein 3; CatSper3", "protein_names_refseq": "cation channel sperm-associated protein 3 isoform 1; cation channel sperm-associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76856); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12932298;16107607;17227845;17344468;17347248;21224844;21412339;29371110;34225353;34998468", "class_list": "", "function": "CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility, [RefSeq, PubMed]; Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions., [RefSeq, PubMed]; Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase., [RefSeq, PubMed]; Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWA9;Q9D5T9", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005783 endoplasmic reticulum;GO:0001669 acrosomal vesicle;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80W99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y72-1", "uniprot_id": "CSTL1_MOUSE", "mass": 16199.0, "length": 140, "protein_name": "Cystatin-like 1", "gene_name": "Cstl1", "organism": "Mouse", "refseq_name": "cystatin-like 1 isoform 2 precursor", "refseq_ac": "NP_808323", "gene_names_uniprotkb": "Cstl1; Rcet1", "gene_names_refseq": "Cstl1; RCET1; RCET2; RCET3", "protein_names_uniprotkb": "Cystatin-like 1", "protein_names_refseq": "cystatin-like 1 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:228756)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18300157;21750661", "class_list": "", "function": "Primarily expressed in mouse male reproductive tract; may play important roles in mouse spermatocyte and spermatid development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2I7;Q64FK4;Q64FK5", "ec_number_list": "", "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0140448 signaling receptor ligand precursor processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80Y72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZN5-1", "uniprot_id": "CST13_MOUSE", "mass": 16825.0, "length": 141, "protein_name": "Cystatin-13", "gene_name": "Cst13", "organism": "Mouse", "refseq_name": "cystatin-13 precursor", "refseq_ac": "NP_081300", "gene_names_uniprotkb": "Cst13; Cymg1", "gene_names_refseq": "1700006C19Rik; Cst13; Cymg1; Mtcg1", "protein_names_uniprotkb": "Cystatin-13; Cystatin-T", "protein_names_refseq": "cystatin-13 precursor; cystatin-T", "tax_id": 10090, "disease": "", "pathway": " (mmu:69294)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15645076;15689628", "class_list": "", "function": "Cymg1 expression level varied in the different developmental stages of mouse testis, and were coincidental with spermatogenesis and sex maturation., [RefSeq, PubMed]; Cymg1 might play an important role in mouse spermatogenesis and sexual maturation, [RefSeq, PubMed]; May perform a specialized role during sperm development and maturation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAP1", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIQ5-1", "uniprot_id": "CSTF2_MOUSE", "mass": 61341.0, "length": 580, "protein_name": "Cleavage stimulation factor subunit 2", "gene_name": "Cstf2", "organism": "Mouse", "refseq_name": "cleavage stimulation factor subunit 2 isoform 3", "refseq_ac": "NP_001277328", "gene_names_uniprotkb": "Cstf2", "gene_names_refseq": "C630034J23Rik; Cstf2; Cstf64; mir-3112", "protein_names_uniprotkb": "Cleavage stimulation factor subunit 2; CF-1 64 kDa subunit; CSTF 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; CstF-64", "protein_names_refseq": "CF-1 64 kDa subunit; CSTF 64 kDa subunit; cleavage stimulation factor subunit 2 isoform 3; cleavage stimulation factor subunit 2; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776)", "pathway": " (mmu:108062); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11369601;14681198;21750661;25428506;30084848;31219806;32816001;34428180;9736695", "class_list": "", "function": "One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AEJ9;A2AEK0;Q8K1Y6;Q9ERC2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0071920 cleavage body", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BIQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7E9-1", "uniprot_id": "CSTFT_MOUSE", "mass": 65862.0, "length": 632, "protein_name": "Cleavage stimulation factor subunit 2 tau variant", "gene_name": "Cstf2t", "organism": "Mouse", "refseq_name": "cleavage stimulation factor subunit 2 tau variant", "refseq_ac": "NP_112539", "gene_names_uniprotkb": "Cstf2t; Kiaa0689", "gene_names_refseq": "64kDa; Cstf2t; tCstF-64; tauCstF-64", "protein_names_uniprotkb": "Cleavage stimulation factor subunit 2 tau variant; CF-1 64 kDa subunit tau variant; CSTF 64 kDa subunit tau variant; Cleavage stimulation factor 64 kDa subunit tau variant; TauCstF-64", "protein_names_refseq": "CF-1 64 kDa subunit, tau; CSTF 64 kDa subunit, tau; cleavage stimulation factor 64 kDa subunit, tau; cleavage stimulation factor subunit 2 tau variant; cleavage stimulation factor subunit 2 tau; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau", "tax_id": 10090, "disease": "", "pathway": " (mmu:83410); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11113135;14681198;21183079;21489638;23110235;25428506;26700942;27812195;29673127;30084848;34428180", "class_list": "", "function": "Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice Publication Status: Online-Only, [RefSeq, PubMed]; Cstf2t may control other reproductive functions that are not directly linked to the formation of 3' ends of mature polyadenylated mRNAs during male germ cell formation., [RefSeq, PubMed]; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs., [UniProtKB, PubMed]; Primarily supports spermatogenesis, but only incidently supports immune cell function, [RefSeq, PubMed]; The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes., [RefSeq, PubMed]; This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A016;Q8BHH7;Q8C3W7;Q8R2Y1;Q9EPU3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C7E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDS7-1", "uniprot_id": "FA243_MOUSE", "mass": 29348.0, "length": 251, "protein_name": "Uncharacterized protein C21orf140 homolog", "gene_name": "Fam243", "organism": "Mouse", "refseq_name": "uncharacterized protein C21orf140 homolog", "refseq_ac": "NP_083528", "gene_names_uniprotkb": "Fam243; Fam243a", "gene_names_refseq": "4930563D23Rik; Fam243", "protein_names_uniprotkb": "Uncharacterized protein C21orf140 homolog; Protein FAM243A", "protein_names_refseq": "protein FAM243A; uncharacterized protein C21orf140 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:75328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CDS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH20-1", "uniprot_id": "CYPT1_MOUSE", "mass": 18957.0, "length": 168, "protein_name": "Cysteine-rich perinuclear theca protein 1", "gene_name": "Cypt1", "organism": "Mouse", "refseq_name": "cysteine-rich perinuclear theca protein 1 isoform 2", "refseq_ac": "NP_001297390", "gene_names_uniprotkb": "Cypt1; Ckt1r3; Cypt5", "gene_names_refseq": "4931420D14Rik; Ckt1r3; Cypt1; Cypt5; Cypt6; TISP55", "protein_names_uniprotkb": "Cysteine-rich perinuclear theca protein 1", "protein_names_refseq": "basic protein CKT1R3; cysteine-rich perinuclear theca 5; cysteine-rich perinuclear theca 6; cysteine-rich perinuclear theca protein 1 isoform 2; cysteine-rich perinuclear theca protein 1; cysteine-rich postacrosomal PT protein; cysteine-rich postacrosomal perinuclear theca protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15286030;16477651;17342728", "class_list": "", "function": "CYPT1 and the proteins of the paralogous genes constitute a novel, basic cysteine-rich sperm protein family that may contribute to the function of the postacrosomal PT during nuclear shaping., [RefSeq, PubMed]; Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AX51;Q3MSD0;Q3MSD1;Q6P8T4;Q9D4K2;Q9D9I2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0033011 perinuclear theca", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CH20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K129-1", "uniprot_id": "CTXN1_MOUSE", "mass": 9059.0, "length": 82, "protein_name": "Cortexin-1", "gene_name": "Ctxn1", "organism": "Mouse", "refseq_name": "cortexin-1", "refseq_ac": "NP_899138", "gene_names_uniprotkb": "Ctxn1; Ctxn", "gene_names_refseq": "Ctxn1; Ctxn", "protein_names_uniprotkb": "Cortexin-1", "protein_names_refseq": "cortexin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:330695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May mediate extracellular or intracellular signaling of cortical neurons during forebrain development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K129-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZT4-1", "uniprot_id": "CRUM3_MOUSE", "mass": 11921.0, "length": 113, "protein_name": "Protein crumbs homolog 3", "gene_name": "Crb3", "organism": "Mouse", "refseq_name": "protein crumbs homolog 3 isoform 2", "refseq_ac": "NP_001334337", "gene_names_uniprotkb": "Crb3", "gene_names_refseq": "5730439B18; Crb3", "protein_names_uniprotkb": "Protein crumbs homolog 3", "protein_names_refseq": "protein crumbs homolog 3 isoform 2; protein crumbs homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:224912)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12527193;17920587;21145499;21750661;26404741;37737843", "class_list": "", "function": "CRB3 navigates Rab11 trafficking vesicles to promote gammaTuRC assembly during ciliogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (PubMed:21145499). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJV6", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0072659 protein localization to plasma membrane;GO:0045216 cell-cell junction organization;GO:1901890 positive regulation of cell junction assembly;GO:0120193 tight junction organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE73-1", "uniprot_id": "CUL7_MOUSE", "mass": 192292.0, "length": 1689, "protein_name": "Cullin-7", "gene_name": "Cul7", "organism": "Mouse", "refseq_name": "cullin-7", "refseq_ac": "NP_079887", "gene_names_uniprotkb": "Cul7; Kiaa0076", "gene_names_refseq": "2510004L20Rik; C230011P08Rik; Cul7; p185; p193", "protein_names_uniprotkb": "Cullin-7; CUL-7; p185; p193", "protein_names_refseq": "CUL-7; cullin-7", "tax_id": 10090, "disease": "3-M syndrome (Disease Ontology:DOID:0060241)", "pathway": " (mmu:66515); (R-MMU-983168)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12904573;14990695;15142950;16880526;21750661;25428506;30084848;31092637;31219806;31599954;33351822;34203471;34428180;34887587;35820727;38367951", "class_list": "", "function": "Antagonization of p193 and p53 activity relaxes the otherwise stringent regulation of cardiomyocyte cell cycle reentry in the injured adult heart., [RefSeq, PubMed]; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (By similarity). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (By similarity). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (By similarity). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (By similarity). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (By similarity). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (By similarity). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (By similarity). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (PubMed:12904573)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Longitudinal skeletal growth and growth plate morphological characteristics of chondro-tissue specific CUL7 knockout mice., [RefSeq, PubMed]; Role of binding of Cul7 to simian virus 40 large T antigen in cell transformation; may also regulate an important growth control pathway, [RefSeq, PubMed]; This study shows that CUL7 mediates the degradation of activation-Induced Cytidine Deaminase and regulates the Ig class switch recombination in B lymphocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHY3;Q497I2;Q6A0D6;Q6PB63;Q8R3W4;Q9CVD5", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0001570 vasculogenesis;GO:0001890 placenta development;GO:0016567 protein ubiquitination;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8VE73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VII3-1", "uniprot_id": "CSTD1_MOUSE", "mass": 15077.0, "length": 130, "protein_name": "Cystatin domain-containing protein 1", "gene_name": "Cstdc1", "organism": "Mouse", "refseq_name": "cystatin domain-containing protein 1 precursor", "refseq_ac": "NP_084411", "gene_names_uniprotkb": "Cstdc1; Cst14", "gene_names_refseq": "8030411F24Rik; Cst14; Cstdc1", "protein_names_uniprotkb": "Cystatin domain-containing protein 1; Cystatin SC; Cystatin-14", "protein_names_refseq": "cystatin SC; cystatin domain-containing protein 1 precursor; cystatin domain-containing protein 1; cystatin-14", "tax_id": 10090, "disease": "", "pathway": " (mmu:78609)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12444065", "class_list": "", "function": "May play a specialized role in spermatogenesis., [UniProtKB, PubMed]; Unusual amino acid sequence and highly restricted expression suggests that cystatins SC and TE-1 play a very specialized role in the testis and epididymis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX46", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VII3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VY6-1", "uniprot_id": "CYTIP_MOUSE", "mass": 40143.0, "length": 359, "protein_name": "Cytohesin-interacting protein", "gene_name": "Cytip", "organism": "Mouse", "refseq_name": "cytohesin-interacting protein", "refseq_ac": "NP_631939", "gene_names_uniprotkb": "Cytip; Pscdbp", "gene_names_refseq": "A130053M09Rik; Cbp; Cybr; Cytip; Pscdbp", "protein_names_uniprotkb": "Cytohesin-interacting protein; Cbp HE; Cytohesin-binding protein HE; Pleckstrin homology Sec7 and coiled-coil domains-binding protein", "protein_names_refseq": "cbp HE; cytohesin binding protein; cytohesin-binding protein HE; cytohesin-interacting protein; pleckstrin homology, Sec7 and coiled-coil domains, binding protein; tamalin", "tax_id": 10090, "disease": "", "pathway": " (mmu:227929)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11850456;12909129;16809763;16914744;22488362;31219806;31599954;34428180;36210013", "class_list": "", "function": "By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm., [UniProtKB]; Data suggest a suppressive function for Cytip in mouse dendritic cells in limiting immune responses., [RefSeq, PubMed]; Expression in vivo is differentially modulated by type 1 cytokines during lymphocyte maturation, [RefSeq, PubMed]; These data suggest that Cybr is not absolutely required for hematopoietic cell development or function, but stem cells lacking Cybr are at a developmental disadvantage compared to wild-type cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AS77;Q3TZH1;Q8R4T4;Q9QZA9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91VY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WA4-1", "uniprot_id": "CXXC5_MOUSE", "mass": 32812.0, "length": 317, "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "Cxxc5", "organism": "Mouse", "refseq_name": "CXXC-type zinc finger protein 5", "refseq_ac": "NP_598448", "gene_names_uniprotkb": "Cxxc5", "gene_names_refseq": "4930415K17Rik; Cxxc5", "protein_names_uniprotkb": "CXXC-type zinc finger protein 5", "protein_names_refseq": "CXXC-type zinc finger protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67393)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19001364;21750661;24136587;26056233;37355147;37524876;38167023;40885482", "class_list": "", "function": "CXXC5 is a transcriptional activator for Flk-1, mediating BMP signaling for differentiation and migration of endothelial cell and vessel formation., [RefSeq, PubMed]; CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair., [RefSeq, PubMed]; Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]; May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0R4;Q8CES6;Q8CF49", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043467 regulation of generation of precursor metabolites and energy", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91WA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WL5-1", "uniprot_id": "CP4CA_MOUSE", "mass": 58350.0, "length": 508, "protein_name": "Cytochrome P450 4A12A", "gene_name": "Cyp4a12a", "organism": "Mouse", "refseq_name": "cytochrome P450 4A12A precursor", "refseq_ac": "NP_803125", "gene_names_uniprotkb": "Cyp4a12a; Cyp4a12", "gene_names_refseq": "Cyp4a12a; Cyp4a12", "protein_names_uniprotkb": "Cytochrome P450 4A12A; 1.14.14.1; CYPIVA12", "protein_names_refseq": "CYPIVA12; cytochrome P450 4A12A precursor; cytochrome P450 4A12A; cytochrome P450, family 4, subfamily a, polypeptide 12", "tax_id": 10090, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:277753); (R-MMU-211935); (R-MMU-211958); (R-MMU-211979); (R-MMU-2142691)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "17112342;31219806;34428180", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:17112342). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Further catalyzes successive omega-oxidations of 20-HETE to the corresponding dicarboxylic acid, and may contribute to the degradation of PUFA by chain shortening (PubMed:17112342). Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA). Catalyzes stereoselective epoxidation of the last double bond of EPA, displaying a strong preference for the (R,S) stereoisomer (PubMed:17112342). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:17112342)., [UniProtKB, PubMed]; Enzyme is the predominant 20-hydroxyeicosatetraenoic synthase in mouse kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A973;Q3UNE4;Q6P931;Q8N7N3", "ec_number_list": "1.14.14.1;1.14.14.-;1.14.14.80;4.2.1.152;1.14.13.n7;1.14.14.79;5.3.99.5;1.14.14.94", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008392 arachidonate epoxygenase activity;GO:0004497 monooxygenase activity;GO:0050051 leukotriene-B4 20-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0046456 icosanoid biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0001822 kidney development;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X77-1", "uniprot_id": "CY250_MOUSE", "mass": 55765.0, "length": 490, "protein_name": "Cytochrome P450 2C50", "gene_name": "Cyp2c50", "organism": "Mouse", "refseq_name": "cytochrome P450 2C50 isoform 2", "refseq_ac": "NP_001161347", "gene_names_uniprotkb": "Cyp2c50", "gene_names_refseq": "Cyp2c50", "protein_names_uniprotkb": "Cytochrome P450 2C50; 1.14.14.1; CYPIIC50", "protein_names_refseq": "CYPIIC50; cytochrome P450 2C50 isoform 2; cytochrome P450 2C50; cytochrome P450, 2c50", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:107141)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15102943;34428180;35820727;36210013;38740087", "class_list": "", "function": "Metabolizes arachidonic acid to several midchain and omega-terminal hydroxyeicosatetraenoic acids (HETE)., [UniProtKB, PubMed]; Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPJ0;Q6XVG3;Q80X43", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0071614 linoleic acid epoxygenase activity;GO:0101020 estrogen 16-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91X77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZR5-1", "uniprot_id": "CTSR1_MOUSE", "mass": 78706.0, "length": 686, "protein_name": "Cation channel sperm-associated protein 1", "gene_name": "Catsper1", "organism": "Mouse", "refseq_name": "cation channel sperm-associated protein 1", "refseq_ac": "NP_647462", "gene_names_uniprotkb": "Catsper1", "gene_names_refseq": "Catsper1; Catsper; KSper", "protein_names_uniprotkb": "Cation channel sperm-associated protein 1; CatSper1", "protein_names_refseq": "cation channel sperm-associated protein 1; sperm calcium channel 1; sperm ion channel; sperm protein CATSPER1", "tax_id": 10090, "disease": "spermatogenic failure 7 (Disease Ontology:DOID:0070173)", "pathway": " (mmu:225865); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11595941;14657352;14688170;15930155;16036917;16467839;17174296;17227845;17347248;17478420;19516020;21224844;21412339;21750661;34225353;34998468;35248021", "class_list": "", "function": "Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population. Publication Status: Online-Only, [RefSeq, PubMed]; CatSper1 and CatSper2 null sperm show identical phenotypes in mice, [RefSeq, PubMed]; CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization, [RefSeq, PubMed]; Catsper1's function in sperm physiology and role in sperm competition using rodent models, [RefSeq, PubMed]; Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Potential role for CatSper in sperm motility and fertility in mouse and human. CatSper is therefore implicated as a potential target to explore the molecular mechanisms of male infertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PZC3;Q4PZC4;Q4PZC5;Q4PZC6;Q4PZD2", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005886 plasma membrane;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0006816 calcium ion transport;GO:0030317 flagellated sperm motility;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91ZR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925G2-1", "uniprot_id": "CYBR1_MOUSE", "mass": 31844.0, "length": 290, "protein_name": "Plasma membrane ascorbate-dependent reductase CYBRD1", "gene_name": "Cybrd1", "organism": "Mouse", "refseq_name": "plasma membrane ascorbate-dependent reductase CYBRD1", "refseq_ac": "NP_082869", "gene_names_uniprotkb": "Cybrd1; Dcytb", "gene_names_refseq": "2210407P13Rik; Cybrd1; Dcytb", "protein_names_uniprotkb": "Plasma membrane ascorbate-dependent reductase CYBRD1; 7.2.1.3; Cytochrome b reductase 1; Duodenal cytochrome b", "protein_names_refseq": "duodenal cytochrome b; plasma membrane ascorbate-dependent reductase CYBRD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73649); (R-MMU-917937)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11230685;12377801;12547225;12704390;15469906;15764147;15961514;16326980;17068337;18498772;30084848;34428180", "class_list": "", "function": "Dcytb, DMT1, Ireg1 and transferrin receptor 1 have roles in iron transport and hemolysis Erratum:[Biochim Biophys Acta. 2005 Apr 15;1740(1):91], [RefSeq, PubMed]; Iron absorption genes(Dcytb,IREG1,DMT1)were expressed at lower levels in mouse caecum and colon than in the duodenum. They are regulated by body iron requirements., [RefSeq, PubMed]; Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:17068337). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:11230685, PubMed:12547225). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (PubMed:18498772)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in hemochromatosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AUU8;Q9D7U1", "ec_number_list": "7.2.1.3", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0016722 oxidoreductase activity, acting on metal ions;GO:0140575 transmembrane monodehydroascorbate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0010039 response to iron ion;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q925G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925Q8-1", "uniprot_id": "DACH2_MOUSE", "mass": 68588.0, "length": 634, "protein_name": "Dachshund homolog 2", "gene_name": "Dach2", "organism": "Mouse", "refseq_name": "dachshund homolog 2 isoform 1", "refseq_ac": "NP_001136042", "gene_names_uniprotkb": "Dach2", "gene_names_refseq": "9430028N04Rik; Dach2", "protein_names_uniprotkb": "Dachshund homolog 2; Dach2", "protein_names_refseq": "Dach2fiveprime; Dach2threeprime; dachshund 2; dachshund homolog 2 isoform 1; dachshund homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:93837)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11287190;12112464;12130660;21750661", "class_list": "", "function": "Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression also seems to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMA0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0046545 development of primary female sexual characteristics", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q925Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99388-1", "uniprot_id": "CSPRS_MOUSE", "mass": 24061.0, "length": 208, "protein_name": "Component of Sp100-rs", "gene_name": "Csprs", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Csprs; D1Lub1", "gene_names_refseq": "", "protein_names_uniprotkb": "Component of Sp100-rs", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2005907;20173027;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99388-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J10-1", "uniprot_id": "CTU1_MOUSE", "mass": 43823.0, "length": 420, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 1", "gene_name": "Ctu1", "organism": "Mouse", "refseq_name": "cytoplasmic tRNA 2-thiolation protein 1", "refseq_ac": "NP_663557", "gene_names_uniprotkb": "Ctu1; Atpbd3; Ncs6", "gene_names_refseq": "Atpbd3; Ctu1", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 1; 2.7.7.-; ATP-binding domain-containing protein 3; Cytoplasmic tRNA adenylyltransferase 1", "protein_names_refseq": "ATP binding domain 3; ATP-binding domain-containing protein 3; cytoplasmic tRNA 2-thiolation protein 1; cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:233189)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0002144 cytosolic tRNA wobble base thiouridylase complex", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99J10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQT9-1", "uniprot_id": "RCAF1_MOUSE", "mass": 14825.0, "length": 129, "protein_name": "GEL complex subunit OPTI", "gene_name": "Rab5if", "organism": "Mouse", "refseq_name": "GEL complex subunit OPTI", "refseq_ac": "NP_080400", "gene_names_uniprotkb": "Rab5if; Rcaf1", "gene_names_refseq": "1110008F13Rik; RCAF1; RIP5; Rab5if", "protein_names_uniprotkb": "GEL complex subunit OPTI; Obligate partner of TMCO1 insertase; RCAF1; RIP5; Rab5-interacting protein; Respirasome Complex Assembly Factor 1", "protein_names_refseq": "GEL complex subunit OPTI; novel transcript; obligate partner of TMCO1 insertase; rab5-interacting protein; respirasome Complex Assembly Factor 1; uncharacterized protein C20orf24 homolog", "tax_id": 10090, "disease": "craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2 (Disease Ontology:DOID:0081125)", "pathway": " (mmu:67388); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "25428506;27802388;30084848;31536960;34428180", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0097250 mitochondrial respirasome assembly;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWW7-1", "uniprot_id": "CXXC1_MOUSE", "mass": 76167.0, "length": 660, "protein_name": "CXXC-type zinc finger protein 1", "gene_name": "Cxxc1", "organism": "Mouse", "refseq_name": "CXXC-type zinc finger protein 1 isoform 1", "refseq_ac": "NP_083144", "gene_names_uniprotkb": "Cxxc1; Cgbp; Pccx1", "gene_names_refseq": "2410002I16Rik; 5830420C16Rik; Cfp1; Cgbp; Cxxc1; PHF18", "protein_names_uniprotkb": "CXXC-type zinc finger protein 1; CpG-binding protein; PHD finger and CXXC domain-containing protein 1", "protein_names_refseq": "CXXC finger 1 (PHD domain); CXXC-type zinc finger protein 1 isoform 1; CXXC-type zinc finger protein 1; CpG binding protein; PHD finger and CXXC domain-containing protein 1; cpG-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74322); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15923607;27932493;29187734;30365547;34887587;37270588", "class_list": "", "function": "CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis. Publication Status: Online-Only, [RefSeq, PubMed]; Findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development, [RefSeq, PubMed]; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0045322 unmethylated CpG binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CWW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX98-1", "uniprot_id": "CP2U1_MOUSE", "mass": 60578.0, "length": 530, "protein_name": "Cytochrome P450 2U1", "gene_name": "Cyp2u1", "organism": "Mouse", "refseq_name": "cytochrome P450 2U1", "refseq_ac": "NP_082092", "gene_names_uniprotkb": "Cyp2u1", "gene_names_refseq": "8430436A10Rik; Cyp2u1", "protein_names_uniprotkb": "Cytochrome P450 2U1; 1.14.14.80; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 2U1; cytochrome P450, 2u1; long-chain fatty acid omega-monooxygenase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 56 (Disease Ontology:DOID:0110808)", "pathway": " (mmu:71519); (R-MMU-211958); (R-MMU-2142816)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15752708;23176821", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIM3", "ec_number_list": "1.14.14.1;1.14.14.80;4.2.1.152;1.14.14.94", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0052869 arachidonate omega-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CX98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1F3-1", "uniprot_id": "EOLA1_MOUSE", "mass": 18059.0, "length": 157, "protein_name": "Protein EOLA1", "gene_name": "Eola1", "organism": "Mouse", "refseq_name": "protein EOLA1", "refseq_ac": "NP_081063", "gene_names_uniprotkb": "Eola1", "gene_names_refseq": "1110012L19Rik; Eola1", "protein_names_uniprotkb": "Protein EOLA1; Endothelial-overexpressed lipopolysaccharide-associated factor 1; Endothelium and lymphocyte associated ASCH domain 1", "protein_names_refseq": "endothelial-overexpressed lipopolysaccharide-associated factor 1; protein EOLA1; uncharacterized protein CXorf40 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AF50;Q3TDX9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D1F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D269-1", "uniprot_id": "CST11_MOUSE", "mass": 16217.0, "length": 139, "protein_name": "Cystatin-11", "gene_name": "Cst11", "organism": "Mouse", "refseq_name": "cystatin-11 precursor", "refseq_ac": "NP_084335", "gene_names_uniprotkb": "Cst11; CSTE1; Cres2", "gene_names_refseq": "9230101F08Rik; CRES2; Cst11; mCSTE1", "protein_names_uniprotkb": "Cystatin-11; Cystatin-E1; Cystatin-related epididymal spermatogenic protein 2", "protein_names_refseq": "cystatin E1; cystatin-11 precursor; cystatin-related epididymal spermatogenic protein 2; mCST E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78240)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12586767;12700194", "class_list": "", "function": "CRES2 and CRES3 represent new members of a subgroup of cystatin family 2 proteins that likely carry out tissue-specific functions distinct from that of typical cystatins CRES2, CRES3], [RefSeq, PubMed]; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization., [UniProtKB, UniProtKB]; Identification and characterization; investigated the tissue distribution and localization of the corresponding mRNA and examined its regulation in the epididymis by testosterone and/or 17ss-estradiol, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M731", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0030521 androgen receptor signaling pathway;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3S9-1", "uniprot_id": "CPVL_MOUSE", "mass": 54763.0, "length": 478, "protein_name": "Probable serine carboxypeptidase CPVL", "gene_name": "Cpvl", "organism": "Mouse", "refseq_name": "probable serine carboxypeptidase CPVL isoform 1 precursor", "refseq_ac": "NP_001276642", "gene_names_uniprotkb": "Cpvl", "gene_names_refseq": "4933436L16Rik; Cpvl; HVLP", "protein_names_uniprotkb": "Probable serine carboxypeptidase CPVL; 3.4.16.-", "protein_names_refseq": "probable serine carboxypeptidase CPVL isoform 1 precursor; probable serine carboxypeptidase CPVL", "tax_id": 10090, "disease": "", "pathway": " (mmu:71287)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38182149", "class_list": "", "function": "Carboxypeptidase Vitellogenic-Like Promotes the Proliferation and Metastasis of Osteosarcoma through the TGF-beta/Smad Signaling Pathway., [RefSeq, PubMed]; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation., [UniProtKB]; This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RQB1", "ec_number_list": "", "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D3S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D816-1", "uniprot_id": "CP255_MOUSE", "mass": 56096.0, "length": 490, "protein_name": "Cytochrome P450 2C55", "gene_name": "Cyp2c55", "organism": "Mouse", "refseq_name": "cytochrome P450 2C55", "refseq_ac": "NP_082365", "gene_names_uniprotkb": "Cyp2c55; Cyp2c-55", "gene_names_refseq": "2010318C06Rik; CYPIIC55; Cyp2c55", "protein_names_uniprotkb": "Cytochrome P450 2C55; 1.14.14.1; CYPIIC55", "protein_names_refseq": "cytochrome P450 2C55; cytochrome P450, 2c55", "tax_id": 10090, "disease": "", "pathway": " (mmu:72082); (R-MMU-211981)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15102943;18794335;30084848;34428180;39432326", "class_list": "", "function": "Metabolizes arachidonic acid mainly to 19-hydroxyeicosatetraenoic acid (HETE)., [UniProtKB, PubMed]; The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation., [RefSeq, PubMed]; The mechanism of regulation of CYP2C55 and other detoxifying systems in Cyp3a(-/-) mice is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.-;4.2.1.152;1.14.13.n7;5.3.99.5", "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0071614 linoleic acid epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0042573 retinoic acid metabolic process;GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA42-1", "uniprot_id": "CMIP1_MOUSE", "mass": 15588.0, "length": 136, "protein_name": "Ciliary microtubule inner protein 1", "gene_name": "Cimip1", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 1", "refseq_ac": "NP_082434", "gene_names_uniprotkb": "Cimip1", "gene_names_refseq": "1700021F07Rik; Cimip1", "protein_names_uniprotkb": "Ciliary microtubule inner protein 1; Uncharacterized protein C20orf85 homolog", "protein_names_refseq": "ciliary microtubule inner protein 1; uncharacterized protein C20orf85 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YT4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DA42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBW0-1", "uniprot_id": "CP4V2_MOUSE", "mass": 60939.0, "length": 525, "protein_name": "Cytochrome P450 4V2", "gene_name": "Cyp4v2", "organism": "Mouse", "refseq_name": "cytochrome P450 4V2", "refseq_ac": "NP_598730", "gene_names_uniprotkb": "Cyp4v2; Cyp4v3", "gene_names_refseq": "Cyp4v2; Cyp4v3", "protein_names_uniprotkb": "Cytochrome P450 4V2; 1.14.14.79; 1.14.14.80; Docosahexaenoic acid omega-hydroxylase CYP4V2; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 4V2; cytochrome P450 4V3; docosahexaenoic acid omega-hydroxylase CYP4V2; long-chain fatty acid omega-monooxygenase", "tax_id": 10090, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (mmu:102294); (R-MMU-211976); (R-MMU-2453902)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17242355;21540332;24066149;30084848;34428180", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Data conclude that within the mouse F11, Klkb1, Cyp4v3 gene cluster, F11 and Cyp4v3 frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.1;1.14.14.80;1.14.14.79", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0102033 long-chain fatty acid omega-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010430 fatty acid omega-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIQ3-1", "uniprot_id": "DBLOH_MOUSE", "mass": 26820.0, "length": 237, "protein_name": "Diablo IAP-binding mitochondrial protein", "gene_name": "Diablo", "organism": "Mouse", "refseq_name": "diablo IAP-binding mitochondrial protein precursor", "refseq_ac": "NP_075721", "gene_names_uniprotkb": "Diablo; Smac", "gene_names_refseq": "0610041G12Rik; 1700006L01Rik; Diablo; Smac", "protein_names_uniprotkb": "Diablo IAP-binding mitochondrial protein; Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac", "protein_names_refseq": "diablo IAP-binding mitochondrial protein precursor; diablo homolog, mitochondrial; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 64 (Disease Ontology:DOID:0110585); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:66593); (R-MMU-111457); (R-MMU-111463); (R-MMU-111464); (R-MMU-111469); (R-MMU-9627069)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10929712;11971981;12011074;15178455;21183079;21750661;23479728;25428506;36063885;36288343;37507081", "class_list": "", "function": "Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice., [RefSeq, PubMed]; Data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function., [RefSeq, PubMed]; Mitochondrial activation by Bid is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release, [RefSeq, PubMed]; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542V8;Q9CZD1;Q9DCD3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JIQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLL0-1", "uniprot_id": "CRIM1_MOUSE", "mass": 114066.0, "length": 1037, "protein_name": "Cysteine-rich motor neuron 1 protein", "gene_name": "Crim1", "organism": "Mouse", "refseq_name": "cysteine-rich motor neuron 1 protein isoform 1 precursor", "refseq_ac": "NP_056615", "gene_names_uniprotkb": "Crim1", "gene_names_refseq": "Crim1", "protein_names_uniprotkb": "Cysteine-rich motor neuron 1 protein; CRIM-1", "protein_names_refseq": "CRIM-1; cysteine rich transmembrane BMP regulator 1 (chordin like); cysteine-rich motor neuron 1 protein isoform 1 precursor; cysteine-rich motor neuron 1 protein", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:50766)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10642437;10842084;11084657;12464430;21750661;25428506;30899004;31219806;34686337", "class_list": "", "function": "CRIM1 has a role in capillary formation and maintainance during angiogenesis, [RefSeq, PubMed]; Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting., [RefSeq, PubMed]; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q497W4", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JLL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUS4-1", "uniprot_id": "CXA10_MOUSE", "mass": 57127.0, "length": 505, "protein_name": "Gap junction alpha-10 protein", "gene_name": "Gja10", "organism": "Mouse", "refseq_name": "gap junction alpha-10 protein", "refseq_ac": "NP_001398782", "gene_names_uniprotkb": "Gja10", "gene_names_refseq": "Cx-57; Cx59; Cxnn; Gja10; cx57", "protein_names_uniprotkb": "Gap junction alpha-10 protein; Connexin-57; Cx57", "protein_names_refseq": "connexin n; connexin-57; gap junction alpha-10 protein; gap junction membrane channel protein alpha 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:14610); (R-MMU-112303); (R-MMU-190861)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10329667;12881038;15147297;16820008;17681699;18320035;39627609", "class_list": "", "function": "Cx57 is the first connexin identified in mammalian horizontal cells and the first connexin whose expression is apparently restricted to only one type of neuron., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANV0", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007416 synapse assembly;GO:0009416 response to light stimulus;GO:0050908 detection of light stimulus involved in visual perception;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WUS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYC6-1", "uniprot_id": "DCP2_MOUSE", "mass": 48380.0, "length": 422, "protein_name": "m7GpppN-mRNA hydrolase", "gene_name": "Dcp2", "organism": "Mouse", "refseq_name": "m7GpppN-mRNA hydrolase", "refseq_ac": "NP_081766", "gene_names_uniprotkb": "Dcp2", "gene_names_refseq": "2410015D23Rik; 5730537H01Rik; Dcp2", "protein_names_uniprotkb": "m7GpppN-mRNA hydrolase; 3.6.1.62; mRNA-decapping enzyme 2", "protein_names_refseq": "DCP2 decapping enzyme homolog; m7GpppN-mRNA hydrolase; mRNA-decapping enzyme 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70640); (R-MMU-430039); (R-MMU-450385); (R-MMU-450513); (R-MMU-450604)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "17242355;21070968;21183079;21750661;22252322;23136299;37097350", "class_list": "", "function": "Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (By similarity). Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (By similarity)., [UniProtKB, UniProtKB, PubMed]; In this study the increase in Irf-7 mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 mRNA, suggesting that Dcp2 normally modulates Irf-7 mRNA stability., [RefSeq, PubMed]; Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis., [RefSeq, PubMed]; Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia., [RefSeq, PubMed]; The results showed that DCP1A and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLD9", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.4.13;3.1.13.-;3.1.13.4;3.1.26.-;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004534 5'-3' RNA exonuclease activity;GO:0070034 telomerase RNA binding;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030054 cell junction;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0043488 regulation of mRNA stability;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CYC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V82-1", "uniprot_id": "DEFB8_MOUSE", "mass": 6760.0, "length": 60, "protein_name": "Beta-defensin 8", "gene_name": "Defb8", "organism": "Mouse", "refseq_name": "beta-defensin 8 precursor", "refseq_ac": "NP_694748", "gene_names_uniprotkb": "Defb8", "gene_names_refseq": "BD-8; Defb8; Defr1", "protein_names_uniprotkb": "Beta-defensin 8; BD-8; Defensin, beta 8; Defensin-related peptide; Defr1; mBD-8", "protein_names_refseq": "beta-defensin 8 precursor; beta-defensin 8; defensin related 1; defensin-related peptide", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:244334)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11714914;12226710;21750661", "class_list": "", "function": "A synthetic peptide displays antimicrobial activities against S.aureus, P.aeruginosa, E.coli and B.cepacia. The antimicrobial activity against S.aureus, E.coli and B.cepacia is reduced in raised concentration of NaCl, but its action against P.aeruginosa is independent of NaCl concentration., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R556", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91V82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70KL2-1", "uniprot_id": "DFB40_MOUSE", "mass": 8616.0, "length": 73, "protein_name": "Beta-defensin 40", "gene_name": "Defb40", "organism": "Mouse", "refseq_name": "beta-defensin 40 precursor", "refseq_ac": "NP_898860", "gene_names_uniprotkb": "Defb40", "gene_names_refseq": "BD-40; Defb40", "protein_names_uniprotkb": "Beta-defensin 40; BD-40; Defensin, beta 40; mBD-40", "protein_names_refseq": "beta-defensin 40 precursor; beta-defensin 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:360217)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14718547;21750661", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNV5", "ec_number_list": "", "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q70KL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZG4-1", "uniprot_id": "DDIAS_MOUSE", "mass": 99945.0, "length": 898, "protein_name": "DNA damage-induced apoptosis suppressor protein", "gene_name": "Ddias", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ddias; 4632434I11Rik; Noxin", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA damage-induced apoptosis suppressor protein; Nitric oxide-inducible gene protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:74041)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17515607;21750661;30084848", "class_list": "", "function": "May be an anti-apoptotic protein involved in DNA repair or cell survival., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2T1E9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006915 apoptotic process;GO:0007286 spermatid development;GO:0006974 DNA damage response;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NZG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56391-1", "uniprot_id": "CX6B1_MOUSE", "mass": 10071.0, "length": 86, "protein_name": "Cytochrome c oxidase subunit 6B1", "gene_name": "Cox6b1", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 6B1", "refseq_ac": "NP_079904", "gene_names_uniprotkb": "Cox6b1; Cox6b", "gene_names_refseq": "2010000G05Rik; COX VIb-1; Cox6b1; Cox6b", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6B1; COX VIb-1; Cytochrome c oxidase subunit VIb isoform 1", "protein_names_refseq": "cytochrome c oxidase subunit 6B1; cytochrome c oxidase, subunit VIb polypeptide 1", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 7 (Disease Ontology:DOID:0070494); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:110323); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "16291927;21750661;23576753;25605945;31219806;32848054;34428180;34616041;36288343;37453647;37507081;38575788;39927985;40885482", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:34616041, PubMed:38575788). Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water (PubMed:34616041, PubMed:38575788). Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)) (PubMed:34616041, PubMed:38575788). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:34616041, PubMed:38575788)., [UniProtKB, PubMed, PubMed]; Gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q545A3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0097228 sperm principal piece;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P56391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60925-1", "uniprot_id": "DBP_MOUSE", "mass": 34380.0, "length": 325, "protein_name": "D site-binding protein", "gene_name": "Dbp", "organism": "Mouse", "refseq_name": "D site-binding protein isoform 1", "refseq_ac": "NP_058670", "gene_names_uniprotkb": "Dbp", "gene_names_refseq": "Dbp", "protein_names_uniprotkb": "D site-binding protein; Albumin D box-binding protein; Albumin D-element-binding protein", "protein_names_refseq": "D site-binding protein isoform 1; albumin D box-binding protein; albumin D-element-binding protein; d site-binding protein", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13170)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15175240;21183079;21750661;34428180;36241625;8617210", "class_list": "", "function": "Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. [provided by RefSeq, Feb 2014]., [RefSeq]; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCX3", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q60925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12399-1", "uniprot_id": "CTL2A_MOUSE", "mass": 15883.0, "length": 137, "protein_name": "Protein CTLA-2-alpha", "gene_name": "Ctla2a", "organism": "Mouse", "refseq_name": "protein CTLA-2-alpha isoform a precursor", "refseq_ac": "NP_031822", "gene_names_uniprotkb": "Ctla2a", "gene_names_refseq": "Ctla-2a; Ctla2a", "protein_names_uniprotkb": "Protein CTLA-2-alpha; Cytotoxic T-lymphocyte-associated protein 2-alpha", "protein_names_refseq": "protein CTLA-2-alpha isoform a precursor; protein CTLA-2-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:13024)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11829493;21750661;25514977;27586811;2786470;28759565", "class_list": "", "function": "CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP Publication Status: Online-Only, [RefSeq, PubMed]; Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta., [RefSeq, PubMed]; Not known, expressed in activated T-cell., [UniProtKB]; That the fine equilibrium between synthesis and secretion of cathespin L and CTLA-2alpha is part of the brain processes to maintain normal growth and development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91V07", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030425 dendrite", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0045589 regulation of regulatory T cell differentiation;GO:0010955 negative regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12399-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12400-1", "uniprot_id": "CTL2B_MOUSE", "mass": 13122.0, "length": 113, "protein_name": "Protein CTLA-2-beta", "gene_name": "Ctla2b", "organism": "Mouse", "refseq_name": "protein CTLA-2-beta isoform b", "refseq_ac": "NP_001139273", "gene_names_uniprotkb": "Ctla2b", "gene_names_refseq": "Ctla-2b; Ctla2b", "protein_names_uniprotkb": "Protein CTLA-2-beta; Cytotoxic T-lymphocyte-associated protein 2-beta", "protein_names_refseq": "protein CTLA-2-beta isoform b; protein CTLA-2-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:13025)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11829493;14681235;21750661;2786470;28759565", "class_list": "", "function": "CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP Publication Status: Online-Only, [RefSeq, PubMed]; Expression of CTLA-2beta in the decidua may regulate implantation of the embryo by neutralizing the activities of one or more proteases generated by the proliferating trophoblast, [RefSeq, PubMed]; Not known, expressed in activated T-cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBK9;Q541S2", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LC2-1", "uniprot_id": "CSTF1_MOUSE", "mass": 48382.0, "length": 431, "protein_name": "Cleavage stimulation factor subunit 1", "gene_name": "Cstf1", "organism": "Mouse", "refseq_name": "cleavage stimulation factor subunit 1", "refseq_ac": "NP_077161", "gene_names_uniprotkb": "Cstf1", "gene_names_refseq": "1700057K18Rik; Cstf1", "protein_names_uniprotkb": "Cleavage stimulation factor subunit 1; CF-1 50 kDa subunit; CSTF 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; CstF-50", "protein_names_refseq": "CF-1 50 kDa subunit; CSTF 50 kDa subunit; cleavage stimulation factor 50 kDa subunit; cleavage stimulation factor subunit 1; cstF-50", "tax_id": 10090, "disease": "", "pathway": " (mmu:67337); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;25428506;31219806;34203471;34428180", "class_list": "", "function": "One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMB8;Q8BJW1;Q9CSU8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005848 mRNA cleavage stimulating factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99LC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6X919-1", "uniprot_id": "D19L1_MOUSE", "mass": 84187.0, "length": 746, "protein_name": "Protein C-mannosyl-transferase DPY19L1", "gene_name": "Dpy19l1", "organism": "Mouse", "refseq_name": "protein C-mannosyl-transferase DPY19L1", "refseq_ac": "NP_766508", "gene_names_uniprotkb": "Dpy19l1", "gene_names_refseq": "1100001I19Rik; 6030402K12; Dpy19l1", "protein_names_uniprotkb": "Protein C-mannosyl-transferase DPY19L1; 2.4.1.-; Dpy-19-like protein 1; Protein dpy-19 homolog 1", "protein_names_refseq": "dpy-19-like 1; dpy-19-like protein 1; probable C-mannosyltransferase DPY19L1; protein C-mannosyl-transferase DPY19L1; protein dpy-19 homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:244745)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;22028030;27959946;28202721", "class_list": "glycogene;glycosyltransferase", "function": "C-mannosyltransferase that mediates the C-mannosylation tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW consensus sequence (PubMed:28202721). C-mannosylates the first two tryptophans in the WxxWxxWxxC sequence motif in thrombospondin (TSP) type-1 repeats of UNC5A (PubMed:28202721). Regulates neurite extension during development (PubMed:27959946, PubMed:28202721)., [UniProtKB, PubMed, PubMed]; Dpy19L1 is localized to the ER membrane and regulates neurite extension during development. Publication Status: Online-Only, [RefSeq, PubMed]; Dpy19l1 is required for the proper radial migration of glutamatergic neurons, an evolutionarily conserved role for the Dpy19 family in neuronal migration. Erratum:[Development. 2012 Mar;139(6):1225], [RefSeq, PubMed]; Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP31;Q8CD79", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0018103 protein C-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6X919-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWS0-1", "uniprot_id": "DDAH1_MOUSE", "mass": 31381.0, "length": 285, "protein_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "gene_name": "Ddah1", "organism": "Mouse", "refseq_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "refseq_ac": "NP_081269", "gene_names_uniprotkb": "Ddah1", "gene_names_refseq": "2410006N07Rik; 2510015N06Rik; Ddah1", "protein_names_uniprotkb": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; 3.5.3.18; DDAH-1; DDAHI; Dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1", "protein_names_refseq": "DDAH-1; DDAHI; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; dimethylargininase-1", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:69219); (R-MMU-203615)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17273169;21493890;21750661;22645316;32848054;34428180;36792833;37296100;37453647;38354630;40021952;40885482", "class_list": "", "function": "DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., [RefSeq, PubMed]; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation., [UniProtKB, PubMed, PubMed, PubMed]; Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF65", "ec_number_list": "3.5.3.18", "go_molecular_function": "GO:0016403 dimethylargininase activity;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0030235 nitric-oxide synthase regulator activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0043116 negative regulation of vascular permeability;GO:0045766 positive regulation of angiogenesis;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CWS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AI0-1", "uniprot_id": "DCC1_MOUSE", "mass": 45522.0, "length": 399, "protein_name": "Sister chromatid cohesion protein DCC1", "gene_name": "DSCC1; Dscc1", "organism": "Mouse", "refseq_name": "sister chromatid cohesion protein DCC1 isoform 2", "refseq_ac": "NP_898912", "gene_names_uniprotkb": "DSCC1; Dscc1; DCC1", "gene_names_refseq": "2010006I05Rik; 2600005O03Rik; Dcc1; Dscc1", "protein_names_uniprotkb": "Sister chromatid cohesion protein DCC1; Defective in sister chromatid cohesion protein 1 homolog", "protein_names_refseq": "defective in sister chromatid cohesion 1 homolog; defective in sister chromatid cohesion protein 1 homolog; sister chromatid cohesion protein DCC1 isoform 2; sister chromatid cohesion protein DCC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72107); (R-MMU-174411)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZL5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006275 regulation of DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0034088 maintenance of mitotic sister chromatid cohesion;GO:0034421 post-translational protein acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14AI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17515-1", "uniprot_id": "CXL10_MOUSE", "mass": 10789.0, "length": 98, "protein_name": "C-X-C motif chemokine 10", "gene_name": "Cxcl10", "organism": "Mouse", "refseq_name": "C-X-C motif chemokine 10 precursor", "refseq_ac": "NP_067249", "gene_names_uniprotkb": "Cxcl10; Crg2; Ifi10; Inp10; Scyb10", "gene_names_refseq": "C7; CRG-2; Cxcl10; INP10; IP-10; IP10; Ifi10; Scyb10; gIP-10; mob-1", "protein_names_uniprotkb": "C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; C7; Gamma-IP10; IP-10; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10", "protein_names_refseq": "10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10 precursor; C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; gamma-IP10; interferon activated gene 10; interferon-gamma induced protein CRG-2; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small-inducible cytokine B10", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); common cold (Disease Ontology:DOID:10459); adult respiratory distress syndrome (Disease Ontology:DOID:11394); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); interstitial cystitis (Disease Ontology:DOID:13949); thoracic aortic aneurysm (Disease Ontology:DOID:14004); renovascular hypertension (Disease Ontology:DOID:1591); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); hepatocellular carcinoma (Disease Ontology:DOID:684); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); encephalitis (Disease Ontology:DOID:9588); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:15945); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15456824;18560148;18624292;19017990;2118520;21750661;2189406;28468883;28623423;8145049;8454640", "class_list": "", "function": "Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed:28623423). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed:18624292, PubMed:19017990, PubMed:28468883). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed:15456824)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWX9-1", "uniprot_id": "DDX47_MOUSE", "mass": 50639.0, "length": 455, "protein_name": "Probable ATP-dependent RNA helicase DDX47", "gene_name": "Ddx47", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX47", "refseq_ac": "NP_080636", "gene_names_uniprotkb": "Ddx47", "gene_names_refseq": "4930588A18Rik; Ddx47", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX47; 3.6.4.13; DEAD box protein 47", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; DEAD box protein 47; probable ATP-dependent RNA helicase DDX47", "tax_id": 10090, "disease": "", "pathway": " (mmu:67755); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18299400;21750661;21952136;25428507;25605945;28528544;31219806", "class_list": "", "function": "Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;2.1.1.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.1.13.-;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CWX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0V2-1", "uniprot_id": "DCNL3_MOUSE", "mass": 34439.0, "length": 304, "protein_name": "DCN1-like protein 3", "gene_name": "Dcun1d3", "organism": "Mouse", "refseq_name": "DCN1-like protein 3", "refseq_ac": "NP_001157175", "gene_names_uniprotkb": "Dcun1d3; SCCRO3", "gene_names_refseq": "1700020A13Rik; DCNL3; Dcun1d3; SCCRO3", "protein_names_uniprotkb": "DCN1-like protein 3; DCNL3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3; SCCRO3; Squamous cell carcinoma-related oncogene 3", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 3; DCN1-like protein 3; DCUN1 domain-containing protein 3; defective in cullin neddylation protein 1-like protein 3; squamous cell carcinoma-related oncogene 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:233805); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;26792857;34428180", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010332 response to gamma radiation;GO:0043065 positive regulation of apoptotic process;GO:0030308 negative regulation of cell growth;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:2000435 negative regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K0V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70694-1", "uniprot_id": "DHB5_MOUSE", "mass": 37048.0, "length": 323, "protein_name": "Estradiol 17 beta-dehydrogenase 5", "gene_name": "Akr1c6", "organism": "Mouse", "refseq_name": "estradiol 17 beta-dehydrogenase 5 isoform 1", "refseq_ac": "NP_085114", "gene_names_uniprotkb": "Akr1c6; Hsd17b5", "gene_names_refseq": "3alpha-HSD; Akr1c1; Akr1c6; Hsd17b5", "protein_names_uniprotkb": "Estradiol 17 beta-dehydrogenase 5; 1.1.1.-; 17-beta-HSD 5", "protein_names_refseq": "17-beta-HSD 5; 17HSD type 5; aldo-keto reductase family 1, member C1 (aldehyde reductase); estradiol 17 beta-dehydrogenase 5 isoform 1; estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); hydroxysteroid 17-beta dehydrogenase 5", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:83702); (R-MMU-193368); (R-MMU-193775); (R-MMU-193807); (R-MMU-2162123); (R-MMU-5365859); (R-MMU-975634); (R-MMU-9757110)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "10500239;21750661;26160177;30084848;34428180;37453647;7737980", "class_list": "", "function": "A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified., [RefSeq, PubMed]; Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a-stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.21;1.1.1.-;1.1.1.149;1.1.-.-;1.1.1.209", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0031406 carboxylic acid binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0047787 Delta4-3-oxosteroid 5beta-reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0006693 prostaglandin metabolic process;GO:0006694 steroid biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VA1-1", "uniprot_id": "CTL4_MOUSE", "mass": 78723.0, "length": 707, "protein_name": "Choline transporter-like protein 4", "gene_name": "Slc44a4", "organism": "Mouse", "refseq_name": "choline transporter-like protein 4", "refseq_ac": "NP_076046", "gene_names_uniprotkb": "Slc44a4; Ctl4; Ng22; TPPT1", "gene_names_refseq": "2210409B01Rik; NG22; Slc44a4; mTPPT1", "protein_names_uniprotkb": "Choline transporter-like protein 4; Solute carrier family 44 member 4; Thiamine pyrophosphate transporter 1; mTPPT1", "protein_names_refseq": "choline transporter-like protein 4; thiamine pyrophosphate transporter 1", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 72 (Disease Ontology:DOID:0080268); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:70129); (R-MMU-1483191); (R-MMU-9958517)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14656967;19349973;21750661;24379411;26901654;30084848;38713615", "class_list": "", "function": "Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology., [RefSeq, PubMed]; Epigenetic mechanisms (histone modifications) play a role in determining the tissue-specific pattern of expression of the TPPT along the GI tract. Erratum:[PLoS One. 2017 Oct 11;12(10):e0186550. doi: 10.1371/journal.pone.0186550. PMID: 29020075] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ02;Q9CVA7", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0090422 thiamine pyrophosphate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport;GO:0030974 thiamine pyrophosphate transmembrane transport;GO:0032475 otolith formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91VA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61093-1", "uniprot_id": "CY24B_MOUSE", "mass": 65305.0, "length": 570, "protein_name": "NADPH oxidase 2", "gene_name": "Cybb", "organism": "Mouse", "refseq_name": "NADPH oxidase 2", "refseq_ac": "NP_031833", "gene_names_uniprotkb": "Cybb; Cgd", "gene_names_refseq": "CGD91-phox; Cgd; Cybb; Cyd; Nox2; gp91-1; gp91phox", "protein_names_uniprotkb": "NADPH oxidase 2; 1.6.3.-; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome", "protein_names_refseq": "NADPH oxidase 2; cytochrome b-245 heavy chain; cytochrome b558 subunit beta; heme-binding membrane glycoprotein gp91phox; neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); X-linked chronic granulomatous disease (Disease Ontology:DOID:0070195); immunodeficiency 34 (Disease Ontology:DOID:0112000); hypertension (Disease Ontology:DOID:10763); chronic granulomatous disease (Disease Ontology:DOID:3265); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:13058); (R-MMU-1222556); (R-MMU-1236973); (R-MMU-3299685); (R-MMU-4420097); (R-MMU-5668599); (R-MMU-6798695); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "21551061;21750661;23118986;24739962;26194095;26740625;28351984;31219806;34428180;8634451", "class_list": "", "function": "A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages, [RefSeq, PubMed]; Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (PubMed:24739962)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;2.7.1.153;2.7.1.137;1.1.1.-;2.7.11.13;3.2.1.20;3.1.4.4;2.7.10.1;3.4.24.-;2.3.1.78;2.7.10.2;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;1.6.3.1;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0006952 defense response;GO:0006954 inflammatory response;GO:0007584 response to nutrient;GO:0045087 innate immune response;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0Y1-1", "uniprot_id": "DCTN3_MOUSE", "mass": 20978.0, "length": 186, "protein_name": "Dynactin subunit 3", "gene_name": "Dctn3", "organism": "Mouse", "refseq_name": "dynactin subunit 3 isoform B", "refseq_ac": "NP_001153037", "gene_names_uniprotkb": "Dctn3", "gene_names_refseq": "Dctn3; p24", "protein_names_uniprotkb": "Dynactin subunit 3; Dynactin light chain p24", "protein_names_refseq": "dynactin light chain (P24); dynactin light chain p24; dynactin subunit 3 isoform B; dynactin subunit 3; p24 dynactin light chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:53598); (R-MMU-2132295); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-8854518)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "21750661;34428180;9786090", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR43;Q9D039", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0061640 cytoskeleton-dependent cytokinesis;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z0Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPL9-1", "uniprot_id": "DDX55_MOUSE", "mass": 68465.0, "length": 600, "protein_name": "ATP-dependent RNA helicase DDX55", "gene_name": "Ddx55", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX55 isoform 1", "refseq_ac": "NP_080685", "gene_names_uniprotkb": "Ddx55; Kiaa1595", "gene_names_refseq": "2810021H22Rik; Ddx55; mKIAA1595", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX55; 3.6.4.13; DEAD box protein 55", "protein_names_refseq": "ATP-dependent RNA helicase DDX55 isoform 1; ATP-dependent RNA helicase DDX55; DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; DEAD box protein 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:67848)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661;29187734;31219806;34428180", "class_list": "", "function": "Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q149H5;Q3U460;Q8BZR1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0070180 large ribosomal subunit rRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZPL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3V6-1", "uniprot_id": "CUED1_MOUSE", "mass": 42780.0, "length": 388, "protein_name": "CUE domain-containing protein 1", "gene_name": "Cuedc1", "organism": "Mouse", "refseq_name": "CUE domain-containing protein 1 isoform 1", "refseq_ac": "NP_932130", "gene_names_uniprotkb": "Cuedc1", "gene_names_refseq": "C330016O16Rik; Cuedc1", "protein_names_uniprotkb": "CUE domain-containing protein 1", "protein_names_refseq": "CUE domain-containing protein 1 isoform 1; CUE domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103841)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SXC2", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R3V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70298-1", "uniprot_id": "CUX2_MOUSE", "mass": 154664.0, "length": 1426, "protein_name": "Homeobox protein cut-like 2", "gene_name": "Cux2", "organism": "Mouse", "refseq_name": "homeobox protein cut-like 2 isoform 1", "refseq_ac": "NP_001299837", "gene_names_uniprotkb": "Cux2; Cutl2", "gene_names_refseq": "1700051K22Rik; Cutl2; Cux-2; Cux2", "protein_names_uniprotkb": "Homeobox protein cut-like 2; Homeobox protein Cux-2", "protein_names_refseq": "homeobox protein Cux-2; homeobox protein cut-like 2 isoform 1; homeobox protein cut-like 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 67 (Disease Ontology:DOID:0112203); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (mmu:13048)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18033766;20510857;21750661;25428506;8798433", "class_list": "", "function": "This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain (PubMed:18033766, PubMed:20510857). Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III (PubMed:20510857). Binds to DNA in a sequence-specific manner., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P1E6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K363-1", "uniprot_id": "DDX18_MOUSE", "mass": 74181.0, "length": 660, "protein_name": "ATP-dependent RNA helicase DDX18", "gene_name": "Ddx18", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX18", "refseq_ac": "NP_080136", "gene_names_uniprotkb": "Ddx18", "gene_names_refseq": "2310005B10Rik; Ddx18", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX18; 3.6.4.13; DEAD box protein 18", "protein_names_refseq": "ATP-dependent RNA helicase DDX18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; DEAD box protein 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:66942)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;25428506;30084848;30779550;31219806;31914400;34418053;34428180;34887587;35820727", "class_list": "", "function": "ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (By similarity). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells (PubMed:31914400). Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (PubMed:31914400)., [UniProtKB, UniProtKB, PubMed]; DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation., [RefSeq, PubMed]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3MIB0;Q8BVZ2;Q9D2E0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0071392 cellular response to estradiol stimulus;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K363-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5V5-1", "uniprot_id": "CUL5_MOUSE", "mass": 90974.0, "length": 780, "protein_name": "Cullin-5", "gene_name": "Cul5", "organism": "Mouse", "refseq_name": "cullin-5 isoform 2", "refseq_ac": "NP_001155090", "gene_names_uniprotkb": "Cul5", "gene_names_refseq": "4921514I20Rik; 8430423K24Rik; C030032G03Rik; C330021I08Rik; Cul5; VACM-1; VACM1", "protein_names_uniprotkb": "Cullin-5; CUL-5", "protein_names_refseq": "CUL-5; cullin-5 isoform 2; vasopressin-activated calcium-mobilizing receptor protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75717); (R-MMU-8863795); (R-MMU-8951664); (R-MMU-9705462); (R-MMU-983168)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17974915;21750661;23806657;24210661;31219806;33300544;34428180;37507081;38177117;38242867;39627609", "class_list": "", "function": "Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17974915, PubMed:23806657, PubMed:24210661). Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component (By similarity). Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (PubMed:17974915, PubMed:24210661). ECS(SOCS1) seems to direct ubiquitination of JAK2 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (By similarity). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (By similarity). ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (By similarity). The ECS(ASB9) complex mediates ubiquitination and degradation of CKB (By similarity). As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC (By similarity). As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby regulating protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration (By similarity). As part of the ECS(RAB40B) complex, mediates LIMA1/EPLIN and RAP2 ubiquitination, thereby regulating actin cytoskeleton dynamics and stress fiber formation during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). May form a cell surface vasopressin receptor (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Publication Status: Online-Only, [RefSeq, PubMed]; The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8[+] T cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMQ6;Q8BV53;Q8C098", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0090734 site of DNA damage", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0021799 cerebral cortex radially oriented cell migration;GO:0016477 cell migration;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D5V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28312-1", "uniprot_id": "DEFA5_MOUSE", "mass": 10519.0, "length": 93, "protein_name": "Alpha-defensin 5", "gene_name": "Defa5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Defa5; Defcr5", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-defensin 5; Defensin-related cryptdin-5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:13239); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1500431;21750661;8188287", "class_list": "", "function": "Probably contributes to the antimicrobial barrier function of the small bowel mucosa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64382", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09035-1", "uniprot_id": "DBIL5_MOUSE", "mass": 9865.0, "length": 87, "protein_name": "Diazepam-binding inhibitor-like 5", "gene_name": "Dbil5", "organism": "Mouse", "refseq_name": "diazepam-binding inhibitor-like 5", "refseq_ac": "NP_067269", "gene_names_uniprotkb": "Dbil5", "gene_names_refseq": "Dbil5; ELP", "protein_names_uniprotkb": "Diazepam-binding inhibitor-like 5; ELP; Endozepine-like peptide", "protein_names_refseq": "diazepam-binding inhibitor-like 5; endozepine-like peptide", "tax_id": 10090, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287)", "pathway": " (mmu:13168)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10951202;40885482;8898349", "class_list": "", "function": "May be involved in the energy metabolism of the mature sperm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O09035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70279-1", "uniprot_id": "ESS2_MOUSE", "mass": 52604.0, "length": 479, "protein_name": "Splicing factor ESS-2 homolog", "gene_name": "Ess2", "organism": "Mouse", "refseq_name": "splicing factor ESS-2 homolog isoform 2", "refseq_ac": "NP_001075102", "gene_names_uniprotkb": "Ess2; Dgcr14; Dgsi; Es2el; Es2", "gene_names_refseq": "D16H22S1269E; Dgcr14; Dgcr1; Dgsi; ES2; Es2el; Ess2", "protein_names_uniprotkb": "Splicing factor ESS-2 homolog; ES2 protein; Expressed sequence 2 embryonic lethal", "protein_names_refseq": "DiGeorge syndrome critical region gene 14; DiGeorge syndrome critical region protein 14; diGeorge syndrome critical region 14 homolog; protein DGCR14; splicing factor ESS-2 homolog isoform 2; splicing factor ESS-2 homolog", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": " (mmu:27886)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20921407;21183079;29187734;31219806;32848054;34428180;35933014;36852467;9037598;9499415", "class_list": "", "function": "May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]; Results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep, [RefSeq, PubMed]; The human ortholog of this gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of human chromosome band 22q11.2. The encoded protein localizes to the nucleus, and the orthologous protein in humans co-purifies with C complex spliceosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional coregulator Ess2 controls survival of post-thymic CD4(+) T cells through the Myc and IL-7 signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91YX1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0007399 nervous system development;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70279-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89098-1", "uniprot_id": "CYTF_MOUSE", "mass": 16380.0, "length": 144, "protein_name": "Cystatin-F", "gene_name": "Cst7", "organism": "Mouse", "refseq_name": "cystatin-F precursor", "refseq_ac": "NP_034107", "gene_names_uniprotkb": "Cst7", "gene_names_refseq": "Cmap; Cst7", "protein_names_uniprotkb": "Cystatin-F; CMAP; Cystatin-7; Cystatin-like metastasis-associated protein; Leukocystatin", "protein_names_refseq": "cystatin-7; cystatin-F precursor; cystatin-F; cystatin-like metastasis-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:13011)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "32947653;38085657;38730470;38879499;9632704", "class_list": "", "function": "Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene., [RefSeq, PubMed]; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system., [UniProtKB]; Monocytes release cystatin F dimer to associate with Abeta and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0030414 peptidase inhibitor activity;GO:0042803 protein homodimerization activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:0006955 immune response;GO:1905146 lysosomal protein catabolic process;GO:0031643 positive regulation of myelination;GO:0002577 regulation of antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00158-1", "uniprot_id": "CYB_MOUSE", "mass": 43210.0, "length": 381, "protein_name": "Cytochrome b", "gene_name": "Mt-Cyb", "organism": "Mouse", "refseq_name": "cytochrome b", "refseq_ac": "NP_904340", "gene_names_uniprotkb": "Mt-Cyb; Cob; Cytb; Mtcyb; mt-Cytb", "gene_names_refseq": "CYTB", "protein_names_uniprotkb": "Cytochrome b; Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit", "protein_names_refseq": "cytochrome b", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:17711); (R-MMU-5419276); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12954771;2176148;25428506;30084848;33300544;34428180;34616041;38575788;6326133;7332926", "class_list": "", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0045471 response to ethanol;GO:0051592 response to calcium ion;GO:0001666 response to hypoxia;GO:0046686 response to cadmium ion;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11477-1", "uniprot_id": "DEFA1_MOUSE", "mass": 10461.0, "length": 93, "protein_name": "Alpha-defensin 1", "gene_name": "Defa1", "organism": "Mouse", "refseq_name": "alpha-defensin 1 precursor", "refseq_ac": "NP_034161", "gene_names_uniprotkb": "Defa1; Defcr1; Defcr", "gene_names_refseq": "Defa1; Defcr1; Defcr", "protein_names_uniprotkb": "Alpha-defensin 1; Cryptdin-1; Defensin-related cryptdin peptide", "protein_names_refseq": "alpha-defensin 1 precursor; alpha-defensin 1; cryptdin-1; defensin related cryptdin peptide 1; defensin-1; defensin-related cryptdin peptide", "tax_id": 10090, "disease": "", "pathway": " (mmu:13216)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1500431;1618314;2351676;2715173;28622386;30718392;31053533;8188287", "class_list": "", "function": "Mouse adenovirus 2 infection was enhanced by enteric alpha-defensins. Publication Status: Online-Only, [RefSeq, PubMed]; Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium., [UniProtKB]; The authors show that the antimicrobial peptide alpha-defensin is functionally sustained during nutrient deprivation because of regulation of the defensin-processing enzyme MMP7 by microbiota- and host-derived factors. Sustained Mmp7 expression requires the microbiota and is mediated by de-repression of the transcription activator Atoh1 upon attenuation of the transcriptional repressor Hes1 in intestinal epithelial cells., [RefSeq, PubMed]; We engineered a monoclonal antibody against HNP-1 to block the interaction with P2X7 and found that the blocking antibody protected mice carrying high copy number of DEFA1/DEFA3 from lethal sepsis. We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information. Erratum:[Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2121889119. doi: 10.1073/pnas.2121889119. PMID: 35074923], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61448", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35174-1", "uniprot_id": "CYT2_MOUSE", "mass": 11842.0, "length": 103, "protein_name": "Stefin-2", "gene_name": "Stfa2", "organism": "Mouse", "refseq_name": "stefin-2", "refseq_ac": "NP_001076014", "gene_names_uniprotkb": "Stfa2; Stf-2; Stf2", "gene_names_refseq": "Stf2; Stfa2", "protein_names_uniprotkb": "Stefin-2", "protein_names_refseq": "stefin-2", "tax_id": 10090, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523)", "pathway": " (mmu:20862); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8468045", "class_list": "", "function": "This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQN4;E9QMN6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004866 endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001533 cornified envelope", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0018149 peptide cross-linking;GO:0010951 negative regulation of endopeptidase activity;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35343-1", "uniprot_id": "CXCR2_MOUSE", "mass": 40425.0, "length": 359, "protein_name": "C-X-C chemokine receptor type 2", "gene_name": "Cxcr2", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 2", "refseq_ac": "NP_034039", "gene_names_uniprotkb": "Cxcr2; Cmkar2; Gpcr16; Il8rb", "gene_names_refseq": "CD128; CDw128; Cmkar2; Cxcr2; Gpcr16; IL-8Rh; IL-8rb; IL8RA; Il8rb; mIL-8RH", "protein_names_uniprotkb": "C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B", "protein_names_refseq": "C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; IL-8 receptor alpha chain; IL-8R B; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor, beta; interleukin-8 receptor type B", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); WHIM syndrome 2 (Disease Ontology:DOID:0060973); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); demyelinating disease (Disease Ontology:DOID:3213); acute pyelonephritis (Disease Ontology:DOID:559); end stage renal disease (Disease Ontology:DOID:783); periapical periodontitis (Disease Ontology:DOID:823); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:12765); (R-MMU-380108); (R-MMU-418594); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "14764687;20947763;30084848;30779550;34428180;7518426;7636264;7961909;8194768;8288218;8288247", "class_list": "", "function": "Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site (PubMed:20947763)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53X27", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35343-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43023-1", "uniprot_id": "CX6A2_MOUSE", "mass": 10749.0, "length": 97, "protein_name": "Cytochrome c oxidase subunit 6A2, mitochondrial", "gene_name": "Cox6a2", "organism": "Mouse", "refseq_name": "cytochrome c oxidase subunit 6A2, mitochondrial precursor", "refseq_ac": "NP_034073", "gene_names_uniprotkb": "Cox6a2", "gene_names_refseq": "Cox6a2; CoxVIaH; VIaH", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A2, mitochondrial; COXVIAH; Cytochrome c oxidase polypeptide VIa-heart", "protein_names_refseq": "cytochrome c oxidase polypeptide VIa-heart; cytochrome c oxidase subunit 6A2, mitochondrial precursor; cytochrome c oxidase subunit 6A2, mitochondrial; cytochrome c oxidase subunit VIa polypeptide 2; subunit VIaH (heart-type)", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 18 (Disease Ontology:DOID:0070503); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:12862); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564); (R-MMU-9864848)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "18250455;26495903;28935714;31155743;34616041;38575788;7592858", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:31155743, PubMed:34616041, PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:31155743, PubMed:34616041, PubMed:38575788). Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (PubMed:31155743)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P43023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48320-1", "uniprot_id": "DCE2_MOUSE", "mass": 65224.0, "length": 585, "protein_name": "Glutamate decarboxylase 2", "gene_name": "Gad2", "organism": "Mouse", "refseq_name": "glutamate decarboxylase 2", "refseq_ac": "NP_032104", "gene_names_uniprotkb": "Gad2; Gad65", "gene_names_refseq": "6330404F12Rik; GAD(65); GAD65; Gad-2; Gad2", "protein_names_uniprotkb": "Glutamate decarboxylase 2; 4.1.1.15; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform", "protein_names_refseq": "65 kDa glutamic acid decarboxylase; GAD-65; glutamate decarboxylase 2", "tax_id": 10090, "disease": "spastic cerebral palsy (Disease Ontology:DOID:0050669); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); gestational diabetes (Disease Ontology:DOID:11714); Stiff-Person syndrome (Disease Ontology:DOID:13366); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); type 1 diabetes mellitus (Disease Ontology:DOID:9744); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14417); (R-MMU-888568); (R-MMU-888590)", "pathway_count": 3, "publication_count": 34, "publication_id_list": "10912505;11106373;11207247;11466400;12186840;12445737;12657523;12796471;14530340;15322170;15763918;15814672;16517713;16641112;16979383;17174605;17336387;17376837;17718717;18395850;19180473;19535636;20406664;20540111;26973647;27069933;28344989;30454875;31274300;33300544;8218409;8243324;8816972;8954991", "class_list": "", "function": "Catalyzes the production of GABA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35519", "ec_number_list": "4.1.1.15;3.6.5.2;3.6.4.10", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0044877 protein-containing complex binding;GO:0004351 glutamate decarboxylase activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0006540 gamma-aminobutyrate shunt;GO:0009449 gamma-aminobutyric acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P48320-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50716-1", "uniprot_id": "DAR12_MOUSE", "mass": 10146.0, "length": 91, "protein_name": "Alpha-defensin-related sequence 12", "gene_name": "Defa-rs12", "organism": "Mouse", "refseq_name": "alpha-defensin-related sequence 12 precursor", "refseq_ac": "NP_031872", "gene_names_uniprotkb": "Defa-rs12; Defcr-rs12", "gene_names_refseq": "CRS4C-5; Defa-rs12; Defcr-rs12", "protein_names_uniprotkb": "Alpha-defensin-related sequence 12; CRS4C5; Cryptdin-related protein 4C-5; Defensin-related cryptdin-related sequence 12", "protein_names_refseq": "alpha-defensin-related sequence 12 precursor; alpha-defensin-related sequence 12; cryptdin-related protein 4C-5; cysteine-rich cryptdin-1-like protein; defensin related cryptdin, related sequence 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:13221)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7896294", "class_list": "", "function": "Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64110", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52950-1", "uniprot_id": "DBX1_MOUSE", "mass": 36334.0, "length": 335, "protein_name": "Homeobox protein DBX1", "gene_name": "Dbx1", "organism": "Mouse", "refseq_name": "homeobox protein DBX1", "refseq_ac": "NP_001005232", "gene_names_uniprotkb": "Dbx1; Dbx", "gene_names_refseq": "Dbx1; Dbx", "protein_names_uniprotkb": "Homeobox protein DBX1; Developing brain homeobox protein 1", "protein_names_refseq": "Mmox C; developing brain homeobox protein 1; homeobox protein DBX1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13172)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11239429;35820727;40885482;7811640", "class_list": "", "function": "Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYQ7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0021521 ventral spinal cord interneuron specification;GO:0021515 cell differentiation in spinal cord", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57757-1", "uniprot_id": "CTNS_MOUSE", "mass": 42203.0, "length": 367, "protein_name": "Cystinosin", "gene_name": "Ctns", "organism": "Mouse", "refseq_name": "cystinosin precursor", "refseq_ac": "NP_112541", "gene_names_uniprotkb": "Ctns", "gene_names_refseq": "Ctns", "protein_names_uniprotkb": "Cystinosin", "protein_names_refseq": "cystinosin precursor; cystinosin", "tax_id": 10090, "disease": "Fanconi syndrome (Disease Ontology:DOID:1062); cystinosis (Disease Ontology:DOID:1064)", "pathway": " (mmu:83429); (R-MMU-5223345); (R-MMU-9959399)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11121245;12370309;17597652;17977621;19349973;21897743;22649030;26449607;28465352", "class_list": "glycogene", "function": "CTNS has a role in proper functioning of the retina and bones, and in mouse behavior, [RefSeq, PubMed]; Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:12370309). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (PubMed:26449607). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (PubMed:28465352)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Temporospatial pattern of cystine accumulation in Ctns-/- mice parallels that of patients and validates the mice as a model for the ocular anomalies of cystinosis. Erratum:[Pediatr Res. 2007 Nov;62(5):558], [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015295 solute:proton symporter activity;GO:0015184 L-cystine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1904263 positive regulation of TORC1 signaling;GO:0030878 thyroid gland development;GO:0035623 renal D-glucose absorption;GO:0010730 negative regulation of hydrogen peroxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P57757-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61963-1", "uniprot_id": "DCAF7_MOUSE", "mass": 38926.0, "length": 342, "protein_name": "DDB1- and CUL4-associated factor 7", "gene_name": "Dcaf7", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 7", "refseq_ac": "NP_082222", "gene_names_uniprotkb": "Dcaf7; Han11; Wdr68", "gene_names_refseq": "1700012F10Rik; 2610037L01Rik; Dcaf7; HAN11; Wdr68", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog", "protein_names_refseq": "DDB1- and CUL4-associated factor 7; WD repeat domain 68; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog; WD-repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71833); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16887337;29187734;34428180", "class_list": "", "function": "Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O15491;Q3TMV9;Q9DAE4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P61963-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70658-1", "uniprot_id": "CXCR4_MOUSE", "mass": 40426.0, "length": 359, "protein_name": "C-X-C chemokine receptor type 4", "gene_name": "Cxcr4", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor type 4 isoform 1", "refseq_ac": "NP_034041", "gene_names_uniprotkb": "Cxcr4; Cmkar4; Lestr; Sdf1r", "gene_names_refseq": "CD184; CXC-R4; CXCR-4; Cmkar4; Cxcr4; LESTR; PB-CKR; PBSF/SDF-1; Sdf1r; b2b220Clo", "protein_names_uniprotkb": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; LESTR; Leukocyte-derived seven transmembrane domain receptor; PB-CKR; Pre-B-cell-derived chemokine receptor; SDF-1 receptor; Stromal cell-derived factor 1 receptor", "protein_names_refseq": "C-X-C chemokine receptor type 4 isoform 1; C-X-C chemokine receptor type 4; SDF-1 receptor; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; pre-B-cell-derived chemokine receptor; stromal cell-derived factor 1 receptor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); WHIM syndrome 1 (Disease Ontology:DOID:0060591); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); osteoporosis (Disease Ontology:DOID:11476); rectum cancer (Disease Ontology:DOID:1993); larynx cancer (Disease Ontology:DOID:2596); laryngeal carcinoma (Disease Ontology:DOID:2600); temporal lobe epilepsy (Disease Ontology:DOID:3328); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hemangioblastoma (Disease Ontology:DOID:5241); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); congestive heart failure (Disease Ontology:DOID:6000); leukopenia (Disease Ontology:DOID:615); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:12767); (R-MMU-376176); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "10479460;17322886;18227060;18299400;21183079;21750661;21952136;25605945;26495903;27802388;30084848;30779550;31599954;34428180;8955194;8962122;9103415;9295051;9634237;9634238;9689100;9879064", "class_list": "glycogene", "function": "Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9103415, PubMed:9295051). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing (By similarity). Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (PubMed:9634238, PubMed:9689100)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O09059;O09062;P70233;P70346;Q4KMW1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0050792 regulation of viral process;GO:1903861 positive regulation of dendrite extension;GO:0035470 positive regulation of vascular wound healing;GO:0001934 positive regulation of protein phosphorylation;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P70658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82019-1", "uniprot_id": "DEFB4_MOUSE", "mass": 7129.0, "length": 63, "protein_name": "Beta-defensin 4", "gene_name": "Defb4", "organism": "Mouse", "refseq_name": "beta-defensin 4 precursor", "refseq_ac": "NP_062702", "gene_names_uniprotkb": "Defb4; Bdef4", "gene_names_refseq": "2310001F05Rik; BD-4; Defb4", "protein_names_uniprotkb": "Beta-defensin 4; BD-4; Defensin, beta 4; mBD-4", "protein_names_refseq": "beta-defensin 4 precursor; beta-defensin 4", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:56519); (R-MMU-1461957); (R-MMU-1461973)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10922379;12612195;16897670;20068036;23670560;28270138", "class_list": "", "function": "Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to mouse (but not human) CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036)., [UniProtKB, PubMed]; Murine beta-defensins-1 and -4 were present in newborn skin, [RefSeq, PubMed]; Mycobacterial infection induces the expression of mBD3 and mBD4, and both might participate in the control of mycobacterial growth., [RefSeq, PubMed]; The time course of MBD-4 levels in plasma of trauma mice has a similar trend to the HBD-2 levels in plasma of multiple injured patients. MBD-4 expression is induced in liver tissue after multiple trauma. Publication Status: Online-Only, [RefSeq, PubMed]; This investigation revealed an indispensable role for BD3, BD4, and CRAMP in defense against F. solani-induced keratitis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P82019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01231-1", "uniprot_id": "CXA5_MOUSE", "mass": 40413.0, "length": 358, "protein_name": "Gap junction alpha-5 protein", "gene_name": "Gja5", "organism": "Mouse", "refseq_name": "gap junction alpha-5 protein", "refseq_ac": "NP_001258557", "gene_names_uniprotkb": "Gja5; Cxn-40", "gene_names_refseq": "5730555N10Rik; Cnx40; Cx40; Cxni; Gja-5; Gja5", "protein_names_uniprotkb": "Gap junction alpha-5 protein; Connexin-40; Cx40", "protein_names_refseq": "connexin i; connexin-40; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); overactive bladder syndrome (Disease Ontology:DOID:0070355); atrial standstill 1 (Disease Ontology:DOID:0080662); hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591); glomerulonephritis (Disease Ontology:DOID:2921); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14613); (R-MMU-190861)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1318884;26269457;28179430;28935953;31599954", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071253 connexin binding;GO:0097718 disordered domain specific binding;GO:0055077 gap junction hemi-channel activity;GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling;GO:0086076 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0042995 cell projection;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q01231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0V8T7-1", "uniprot_id": "CTP5C_MOUSE", "mass": 146242.0, "length": 1305, "protein_name": "Contactin-associated protein like 5-3", "gene_name": "Cntnap5c", "organism": "Mouse", "refseq_name": "contactin-associated protein like 5-3 precursor", "refseq_ac": "NP_001075122", "gene_names_uniprotkb": "Cntnap5c; Caspr5-3", "gene_names_refseq": "Caspr5-3; Cntnap5c; EG620292; Gm325", "protein_names_uniprotkb": "Contactin-associated protein like 5-3; Cell recognition molecule Caspr5-3; Cell recognition molecule Caspr5c; Contactin-associated protein-like 5c", "protein_names_refseq": "cell recognition molecule Caspr5-3; cell recognition molecule Caspr5c; contactin-associated protein like 5-3 precursor; contactin-associated protein like 5-3; contactin-associated protein-like 5c", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (mmu:620292)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16845472;30899004;35820727", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]; The three Caspr5 genes are located on chromosomes 1 & 17; all three paralogs are expressed; common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and & in the adult stage, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0043005 neuron projection", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q0V8T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U564-1", "uniprot_id": "DCP1B_MOUSE", "mass": 62720.0, "length": 578, "protein_name": "mRNA-decapping enzyme 1B", "gene_name": "Dcp1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dcp1b", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA-decapping enzyme 1B; 3.6.1.62", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-430039)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;30084848;34428180", "class_list": "", "function": "May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUI2;Q3V333", "ec_number_list": "3.6.1.62;3.6.1.64;3.6.4.13;3.6.1.59;3.6.1.52;3.6.1.10;3.6.1.61", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0034504 protein localization to nucleus;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0097398 cellular response to interleukin-17", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U564-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V2K1-1", "uniprot_id": "CX065_MOUSE", "mass": 21587.0, "length": 191, "protein_name": "Uncharacterized protein CXorf65 homolog", "gene_name": "Gm614", "organism": "Mouse", "refseq_name": "uncharacterized protein CXorf65 homolog isoform 1", "refseq_ac": "NP_001028534", "gene_names_uniprotkb": "Gm614", "gene_names_refseq": "Gm614", "protein_names_uniprotkb": "Uncharacterized protein CXorf65 homolog", "protein_names_refseq": "uncharacterized protein CXorf65 homolog isoform 1; uncharacterized protein CXorf65 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:245536)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33193409", "class_list": "", "function": "Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V2K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DU00-1", "uniprot_id": "DCDC2_MOUSE", "mass": 51953.0, "length": 475, "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "Dcdc2a; Dcdc2", "organism": "Mouse", "refseq_name": "doublecortin domain-containing protein 2 isoform 2", "refseq_ac": "NP_001182546", "gene_names_uniprotkb": "Dcdc2a; Dcdc2; Dcdc2a; Kiaa1154", "gene_names_refseq": "AW492955; Dcdc2a; Dcdc2; RU2", "protein_names_uniprotkb": "Doublecortin domain-containing protein 2", "protein_names_refseq": "doublecortin domain-containing protein 2 isoform 2; doublecortin domain-containing protein 2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 66 (Disease Ontology:DOID:0110517); nephronophthisis 19 (Disease Ontology:DOID:0111126); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sclerosing cholangitis (Disease Ontology:DOID:14268); dyslexia (Disease Ontology:DOID:4428)", "pathway": " (mmu:195208)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21689730;21750661;21883923;25557784;25601850;29232042;38658618", "class_list": "", "function": "DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/beta-catenin signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Dcdc2 KOs displayed deficits on the Pairwise Discrimination task specifically as motion was added to visual stimuli., [RefSeq, PubMed]; Heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits, [RefSeq, PubMed]; Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length., [UniProtKB, UniProtKB]; These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin., [RefSeq, PubMed]; This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZU0;Q80Y99", "ec_number_list": "", "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0005930 axoneme", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0030111 regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5DU00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5G866-1", "uniprot_id": "DFA23_MOUSE", "mass": 10510.0, "length": 93, "protein_name": "Alpha-defensin 23", "gene_name": "Defa23", "organism": "Mouse", "refseq_name": "alpha-defensin 23 precursor", "refseq_ac": "NP_001012307", "gene_names_uniprotkb": "Defa23; Defcr23", "gene_names_refseq": "Defa23; Defcr23", "protein_names_uniprotkb": "Alpha-defensin 23; Defensin-related cryptdin-23", "protein_names_refseq": "alpha-defensin 23 precursor; alpha-defensin 23; defensin-related cryptdin-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:13226); (mmu:497114); (R-MMU-1461973); (R-MMU-1462054); (R-MMU-6798695)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15494476", "class_list": "", "function": "May have microbicidal activities., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059S0", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030496 midbody", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5G866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64263-1", "uniprot_id": "DAR10_MOUSE", "mass": 9777.0, "length": 91, "protein_name": "Alpha-defensin-related sequence 10", "gene_name": "Defa-rs10", "organism": "Mouse", "refseq_name": "alpha-defensin-related sequence 10 precursor", "refseq_ac": "NP_031871", "gene_names_uniprotkb": "Defa-rs10; Defcr-rs10", "gene_names_refseq": "CRS4C-4; Defa-rs10; Defcr-rs10", "protein_names_uniprotkb": "Alpha-defensin-related sequence 10; CRS4C-4; Cryptdin-related protein 4C-4; Defensin-related cryptdin-related sequence 10", "protein_names_refseq": "alpha-defensin-related sequence 10 precursor; alpha-defensin-related sequence 10; cryptdin-related protein 4C-4; defensin related cryptdin, related sequence 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:13219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7896294", "class_list": "", "function": "Apparent precursor of a secreted, cationic, proline- and cysteine-rich peptide that contains Cys-Pro-Xaa repeats. Unlike cryptdin, the proposed mature peptide region lacks the structural motif characteristic of defensins. It may have microbicidal activities (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDL7", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PJN8-1", "uniprot_id": "DALD3_MOUSE", "mass": 58733.0, "length": 538, "protein_name": "DALR anticodon-binding domain-containing protein 3", "gene_name": "Dalrd3", "organism": "Mouse", "refseq_name": "DALR anticodon-binding domain-containing protein 3", "refseq_ac": "NP_080654", "gene_names_uniprotkb": "Dalrd3", "gene_names_refseq": "6330580J24Rik; Dalrd3; mir-425", "protein_names_uniprotkb": "DALR anticodon-binding domain-containing protein 3", "protein_names_refseq": "DALR anticodon-binding domain-containing protein 3", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 86 (Disease Ontology:DOID:0112220)", "pathway": " (mmu:67789)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19224205;20173027;21750661;21952136;25428506;30084848;30779550;31599954;34428180;35820727", "class_list": "", "function": "Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1T1;Q9D1L6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation;GO:0106217 tRNA C3-cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PJN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810A7-1", "uniprot_id": "DDX42_MOUSE", "mass": 101965.0, "length": 929, "protein_name": "ATP-dependent RNA helicase DDX42", "gene_name": "Ddx42", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase DDX42 isoform a", "refseq_ac": "NP_082350", "gene_names_uniprotkb": "Ddx42", "gene_names_refseq": "1810047H21Rik; B430002H05Rik; Ddx42; RHELP; RNAHP; SF3b125", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX42; 3.6.4.13; DEAD box protein 42", "protein_names_refseq": "ATP-dependent RNA helicase DDX42 isoform a; ATP-dependent RNA helicase DDX42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; DEAD box protein 42; RNA helicase-related protein", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908)", "pathway": " (mmu:72047); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "15345747;17242355;17622165;19144319;21183079;24129315;25605945;31219806;34428180;36852467;39627609;40997131", "class_list": "", "function": "ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAN3;Q3TE60;Q8BWZ7;Q9D8Q2", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.2.1.8;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.1.3.16;3.1.3.53;3.6.1.15;3.1.4.-;5.6.2.-;3.4.19.12;7.2.2.-;7.6.2.16;2.7.11.1;2.7.7.19;3.4.21.53;2.7.7.7;2.7.7.49;2.7.7.52;2.7.4.3;2.7.1.78;3.1.27.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q810A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGC9-1", "uniprot_id": "CREG2_MOUSE", "mass": 31764.0, "length": 288, "protein_name": "Protein CREG2", "gene_name": "Creg2", "organism": "Mouse", "refseq_name": "protein CREG2 precursor", "refseq_ac": "NP_733485", "gene_names_uniprotkb": "Creg2", "gene_names_refseq": "A830098L22Rik; Creg2", "protein_names_uniprotkb": "Protein CREG2; Cellular repressor of E1A-stimulated genes 2", "protein_names_refseq": "protein CREG2 precursor; protein CREG2", "tax_id": 10090, "disease": "", "pathway": " (mmu:263764)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12408961;30899004", "class_list": "", "function": "CREG2 are putative secreted glycoproteins and may be novel neuronal extracellular molecules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14AL7;Q8BL64;Q8BX89;Q8K049", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGW4-1", "uniprot_id": "DC122_MOUSE", "mass": 51623.0, "length": 469, "protein_name": "DDB1- and CUL4-associated factor 12-like protein 2", "gene_name": "Dcaf12l2", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 12-like protein 2", "refseq_ac": "NP_780748", "gene_names_uniprotkb": "Dcaf12l2; Wdr40c", "gene_names_refseq": "A130007F10Rik; Dcaf12l2; Wdr40c", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 12-like protein 2; WD repeat-containing protein 40C", "protein_names_refseq": "DDB1- and CUL4-associated factor 12-like protein 2; WD repeat domain 40C; WD repeat-containing protein 40C; WD40 domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:245403)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGZ3-1", "uniprot_id": "DCA12_MOUSE", "mass": 50459.0, "length": 453, "protein_name": "DDB1- and CUL4-associated factor 12", "gene_name": "Dcaf12", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 12", "refseq_ac": "NP_081169", "gene_names_uniprotkb": "Dcaf12; Kiaa1892; Wdr40a", "gene_names_refseq": "1500001L20Rik; 5830424K06Rik; Dcaf12; Wdr40a", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 12; WD repeat-containing protein 40A", "protein_names_refseq": "DDB1- and CUL4-associated factor 12; WD repeat domain 40A; WD repeat-containing protein 40A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68970)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25428506;25605945;30084848;34065512;34428180;37828378", "class_list": "", "function": "Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:34065512). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (By similarity). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z77;Q8BN60;Q8C1Y4;Q9DB95", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0010506 regulation of autophagy;GO:0042110 T cell activation;GO:0016567 protein ubiquitination;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BGZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSD4-1", "uniprot_id": "CXD4_MOUSE", "mass": 40042.0, "length": 364, "protein_name": "Gap junction delta-4 protein", "gene_name": "Gjd4", "organism": "Mouse", "refseq_name": "gap junction delta-4 protein", "refseq_ac": "NP_694726", "gene_names_uniprotkb": "Gjd4", "gene_names_refseq": "9430022F06Rik; Cx39; Cxnu; Gjd4", "protein_names_uniprotkb": "Gap junction delta-4 protein; Connexin-39; Cx39", "protein_names_refseq": "connexin u; connexin-39; connexin39; gap junction delta-4 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:225152); (R-MMU-190861)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12108537;15466892;16613780;21272575", "class_list": "", "function": "Connexin39 gene is expressed in developing striated muscle fibers, [RefSeq, PubMed]; Data show that myogenesis in Cx39 KO mice is accelerated by increased myogenin expression on ED13.5 and 16.5 and increased Cx43 in developing skeletal muscle, and suggest that Cx43 may compensate for loss of Cx39 during myogenesis and regeneration., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; Upon differentiation into myotubes, Cx39 expression increased in mouse embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQL7;Q8C6W6;Q91YD0", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BSD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWQ5-1", "uniprot_id": "DCLK3_MOUSE", "mass": 88228.0, "length": 790, "protein_name": "Serine/threonine-protein kinase DCLK3", "gene_name": "Dclk3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase DCLK3", "refseq_ac": "NP_766516", "gene_names_uniprotkb": "Dclk3; Dcamkl3", "gene_names_refseq": "C730036H08; Dcamkl3; Dclk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK3; 2.7.11.1; CLICK-I and II-related; CLr; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3", "protein_names_refseq": "CLICK-I and II-related; CLr; Click-I, -II related; doublecortin and CaM kinase-like 3; doublecortin-like and CAM kinase-like 3; serine/threonine-protein kinase DCLK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:245038)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16684769;25428506;29534157;30779550", "class_list": "", "function": "This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]., [RefSeq]; This study suggest that the presence of DCLK3 in striatal neurons may play a key role in transcription regulation and chromatin remodelling in these brain cells, and show that reduced expression of the kinase in Huntington's disease could render the striatum highly vulnerable to neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1A748", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BWQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BY89-1", "uniprot_id": "CTL2_MOUSE", "mass": 80110.0, "length": 706, "protein_name": "Choline transporter-like protein 2", "gene_name": "Slc44a2", "organism": "Mouse", "refseq_name": "choline transporter-like protein 2 isoform 1", "refseq_ac": "NP_001186115", "gene_names_uniprotkb": "Slc44a2; Ctl2", "gene_names_refseq": "1110028E10Rik; CTL2; Slc44a2", "protein_names_uniprotkb": "Choline transporter-like protein 2; Solute carrier family 44 member 2", "protein_names_refseq": "choline transporter-like protein 2 isoform 1; choline transporter-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68682); (R-MMU-1483191); (R-MMU-6798163); (R-MMU-6798695); (R-MMU-9958517)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;20665236;21750661;21986210;24846273;30312801;30899004;32135565;32297475;32661250;33300544;34371293;39627609", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter, mainly in mitochondria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway., [UniProtKB, UniProtKB]; Mice lacking SLC44A2 are normal for several hemostasis parameters. Lower levels of circulating plasma VWF are measured in SLC44A2 deficient mice., [RefSeq, PubMed]; Plasma Protein Signatures of a Murine Venous Thrombosis Model and Slc44a2 Knockout Mice Using Quantitative-Targeted Proteomics., [RefSeq, PubMed]; Report age related changes between the two isoforms of CTL2/SLC44A2 in the inner ear., [RefSeq, PubMed]; SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis., [RefSeq, PubMed]; Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells., [RefSeq, PubMed]; The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; The findings show that, for binding to CTL2, Type 2 HNA-3a antibodies require nonpolymorphic amino acid residues in the third, and possibly the second, EC loops of CTL2, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2F1", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BY89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBW4-1", "uniprot_id": "DC121_MOUSE", "mass": 54366.0, "length": 501, "protein_name": "DDB1- and CUL4-associated factor 12-like protein 1", "gene_name": "Dcaf12l1", "organism": "Mouse", "refseq_name": "DDB1- and CUL4-associated factor 12-like protein 1", "refseq_ac": "NP_001177647", "gene_names_uniprotkb": "Dcaf12l1; Wdr40b", "gene_names_refseq": "9330180J20; A230038L21Rik; Dcaf12l1; Decaf12l1; Wdr40b", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 12-like protein 1; WD repeat-containing protein 40B", "protein_names_refseq": "DDB1- and CUL4-associated factor 12-like protein 1; WD repeat domain 40B; WD repeat-containing protein 40B", "tax_id": 10090, "disease": "", "pathway": " (mmu:245404)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17660561;35850260", "class_list": "", "function": "DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NV47;Q8C8E2;Q8CA30;Q8CAL3;Q8CBX8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CBW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1L0-1", "uniprot_id": "CREB5_MOUSE", "mass": 39955.0, "length": 357, "protein_name": "Cyclic AMP-responsive element-binding protein 5", "gene_name": "Creb5", "organism": "Mouse", "refseq_name": "cyclic AMP-responsive element-binding protein 5 isoform 1", "refseq_ac": "NP_001314750", "gene_names_uniprotkb": "Creb5", "gene_names_refseq": "9430076C15Rik; CRE-BPa; Creb5; Crebpa; D430026C09Rik", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 5; CRE-BPa; CREB-5; cAMP-responsive element-binding protein 5", "protein_names_refseq": "cyclic AMP-responsive element-binding protein 5 isoform 1; cyclic AMP-responsive element-binding protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:231991)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;36542062;38424407", "class_list": "", "function": "Binds to the cAMP response element and activates transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent Spontaneous Abortion., [RefSeq, PubMed]; TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCE1;Q3U228;Q8BWH8", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0035497 cAMP response element binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K1L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2D6-1", "uniprot_id": "DCTD_MOUSE", "mass": 20059.0, "length": 178, "protein_name": "Deoxycytidylate deaminase", "gene_name": "Dctd", "organism": "Mouse", "refseq_name": "deoxycytidylate deaminase", "refseq_ac": "NP_001154987", "gene_names_uniprotkb": "Dctd", "gene_names_refseq": "6030466N05Rik; Dctd", "protein_names_uniprotkb": "Deoxycytidylate deaminase; 3.5.4.12; dCMP deaminase", "protein_names_refseq": "deoxycytidylate deaminase", "tax_id": 10090, "disease": "", "pathway": " (mmu:320685); (R-MMU-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP55", "ec_number_list": "3.5.4.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0043174 nucleoside salvage;GO:0009165 nucleotide biosynthetic process;GO:0006220 pyrimidine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1Q8-1", "uniprot_id": "DC1L1_MOUSE", "mass": 56614.0, "length": 523, "protein_name": "Cytoplasmic dynein 1 light intermediate chain 1", "gene_name": "Dync1li1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 1", "refseq_ac": "NP_666341", "gene_names_uniprotkb": "Dync1li1; Dncli1; Dnclic1", "gene_names_refseq": "1110053F02Rik; Dlic1; Dnclic1; Dync1li1; LIC-1", "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 1; DLC-A; Dynein light chain A; Dynein light intermediate chain 1, cytosolic", "protein_names_refseq": "DLC-A; cytoplasmic dynein 1 light intermediate chain 1; dynein light chain A; dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235661); (R-MMU-141430); (R-MMU-141444); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-5663220); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811436); (R-MMU-68877); (R-MMU-9646399); (R-MMU-9648025)", "pathway_count": 14, "publication_count": 23, "publication_id_list": "10.3389/fragi.2021.757801;15345747;16452087;17114649;17242355;19131326;19144319;21183079;22645316;27510948;28135057;30084848;31219806;32782141;32848054;33300544;35727824;35820727;35822049;36210013;36288343;36852467;40885482", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity). Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (By similarity)., [UniProtKB, UniProtKB]; Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. Publication Status: Online-Only, [RefSeq, PubMed]; The DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0030666 endocytic vesicle membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0051301 cell division;GO:1990090 cellular response to nerve growth factor stimulus;GO:0060627 regulation of vesicle-mediated transport;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8R1Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDF3-1", "uniprot_id": "DAPK2_MOUSE", "mass": 42778.0, "length": 370, "protein_name": "Death-associated protein kinase 2", "gene_name": "Dapk2", "organism": "Mouse", "refseq_name": "death-associated protein kinase 2 isoform 2", "refseq_ac": "NP_034149", "gene_names_uniprotkb": "Dapk2", "gene_names_refseq": "Dapk2", "protein_names_uniprotkb": "Death-associated protein kinase 2; 2.7.11.1; DAP kinase 2; DAP-kinase-related protein 1; DRP-1", "protein_names_refseq": "DAP kinase 2; DRP-1; death-associated kinase 2; death-associated protein kinase 2 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13143)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10376525;10629061;17242355;18535204;21183079;21408167;21497605;21750661;24163421;24906443;25428506;26038578;26047703;27653365;30084848", "class_list": "", "function": "Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421)., [UniProtKB, UniProtKB, PubMed]; DAPK2 was substantially up-modulated during late erythropoiesis, [RefSeq, PubMed]; This study links adipocyte expression of an autophagy-regulating kinase, lysosome-mediated clearance and fat cell lipid accumulation; it demonstrates obesity-related attenuated autophagy in adipocytes, and identifies DAPK2 dependence in this regulation., [RefSeq, PubMed]; Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88861;Q9QYM4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle;GO:0034423 autophagosome lumen", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0043276 anoikis;GO:2001242 regulation of intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VDF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDP2-1", "uniprot_id": "STEEP_MOUSE", "mass": 25594.0, "length": 222, "protein_name": "STING ER exit protein", "gene_name": "Steep1", "organism": "Mouse", "refseq_name": "STING ER exit protein", "refseq_ac": "NP_084227", "gene_names_uniprotkb": "Steep1; C330007P06Rik", "gene_names_refseq": "C330007P06Rik; STEEP; Steep1", "protein_names_uniprotkb": "STING ER exit protein; STEEP", "protein_names_refseq": "STING ER exit protein; UPF0428 protein CXorf56 homolog", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 107 (Disease Ontology:DOID:0112054)", "pathway": " (mmu:77644); (R-MMU-72163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;29374277;31219806;32690950;34428180;36210013", "class_list": "", "function": "Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (PubMed:32690950)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A3V4;Q3URC0;Q8C8Z1;Q9CWC1", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0032481 positive regulation of type I interferon production;GO:0032527 protein exit from endoplasmic reticulum;GO:0140896 cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VDP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VD6-1", "uniprot_id": "DEFB6_MOUSE", "mass": 6977.0, "length": 63, "protein_name": "Beta-defensin 6", "gene_name": "Defb6", "organism": "Mouse", "refseq_name": "beta-defensin 6 precursor", "refseq_ac": "NP_473415", "gene_names_uniprotkb": "Defb6", "gene_names_refseq": "BD-6; Defb6", "protein_names_uniprotkb": "Beta-defensin 6; BD-6; Defensin, beta 6; mBD-6", "protein_names_refseq": "beta-defensin 6 precursor; beta-defensin 6", "tax_id": 10090, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (mmu:116746)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11408484;12193721;17215327", "class_list": "", "function": "Has potent antibacterial activity against E.coli (ATCC 25922)., [UniProtKB, PubMed]; The epididymis-specific expression pattern of the beta-defensin isoform mBD-6 has been characterized., [RefSeq, PubMed]; The present findings may unravel a concealed linkage between the innate immune system and the pathophysiology of degenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91VD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921C1-1", "uniprot_id": "CXG3_MOUSE", "mass": 30293.0, "length": 269, "protein_name": "Gap junction gamma-3 protein", "gene_name": "Gjc3", "organism": "Mouse", "refseq_name": "gap junction gamma-3 protein", "refseq_ac": "NP_536698", "gene_names_uniprotkb": "Gjc3; Cx29; Gje1", "gene_names_refseq": "Cx29; Cxnp1; Gjc3; Gje1", "protein_names_uniprotkb": "Gap junction gamma-3 protein; Connexin-29; Cx29; Gap junction epsilon-1 protein", "protein_names_refseq": "connexin p1; connexin-29; gap junction epsilon-1 protein; gap junction gamma-3 protein; gap junction membrane channel protein epsilon 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:118446)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11501764;12151525;12372015;12900929;16926269;20926974;21183079", "class_list": "", "function": "Comparative mapping of Y1 and Y5 receptor subtypes within cell bodies and nerve fibers in the brain. Together with physiological and electrophysiological studies, provides better understanding of NPY neural circuitries., [RefSeq, PubMed]; Cx29 is a second connexin expressed in Schwann cells of sciatic nerve., [RefSeq, PubMed]; Induction of Cxs 29 and 32 in the injury border suggests that altered Cx expression may contribute to the propagation of injury-related and/or regeneration signals after acute brain injury., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZP5;Q8BHJ3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0043209 myelin sheath;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0042552 myelination;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q921C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921V7-1", "uniprot_id": "CTL3_MOUSE", "mass": 73414.0, "length": 656, "protein_name": "Choline transporter-like protein 3", "gene_name": "Slc44a3", "organism": "Mouse", "refseq_name": "choline transporter-like protein 3", "refseq_ac": "NP_663369", "gene_names_uniprotkb": "Slc44a3; Ctl3", "gene_names_refseq": "Slc44a3", "protein_names_uniprotkb": "Choline transporter-like protein 3; Solute carrier family 44 member 3", "protein_names_refseq": "choline transporter-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:213603); (R-MMU-1483191); (R-MMU-9958517)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G5E8A3", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q921V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LI7-1", "uniprot_id": "CSTF3_MOUSE", "mass": 82877.0, "length": 717, "protein_name": "Cleavage stimulation factor subunit 3", "gene_name": "Cstf3", "organism": "Mouse", "refseq_name": "cleavage stimulation factor subunit 3 isoform 1", "refseq_ac": "NP_663504", "gene_names_uniprotkb": "Cstf3", "gene_names_refseq": "4732468G05Rik; CstF-77; Cstf3", "protein_names_uniprotkb": "Cleavage stimulation factor subunit 3; CF-1 77 kDa subunit; CSTF 77 kDa subunit; Cleavage stimulation factor 77 kDa subunit; CstF-77", "protein_names_refseq": "CF-1 77 kDa subunit; CSTF 77 kDa subunit; cleavage stimulation factor 77 kDa subunit; cleavage stimulation factor subunit 3 isoform 1; cleavage stimulation factor subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:228410); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "17242355;17386263;19144319;21183079;21606357;25428506;31219806;34428180;36210013", "class_list": "", "function": "Crystal structure of the HAT (half a TPR) domain of murine CstF-77, as well as its C-terminal subdomain., [RefSeq, PubMed]; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005848 mRNA cleavage stimulating factor complex", "go_biological_process": "GO:0031123 RNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99LI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXX9-1", "uniprot_id": "CUED2_MOUSE", "mass": 31852.0, "length": 284, "protein_name": "CUE domain-containing protein 2", "gene_name": "Cuedc2", "organism": "Mouse", "refseq_name": "CUE domain-containing protein 2 isoform a", "refseq_ac": "NP_001157762", "gene_names_uniprotkb": "Cuedc2", "gene_names_refseq": "3010002G01Rik; Cuedc2", "protein_names_uniprotkb": "CUE domain-containing protein 2", "protein_names_refseq": "CUE domain-containing protein 2 isoform a; CUE domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67116)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;24882011;26182901;27286733;31219806;32393737;34203471;34428180;36210013;37036350", "class_list": "", "function": "CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis., [RefSeq, PubMed]; Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation., [UniProtKB]; Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis., [RefSeq, PubMed]; Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33)-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation. Publication Status: Online-Only, [RefSeq, PubMed]; These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB and STAT3 signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99LC1", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0051775 response to redox state;GO:0009611 response to wounding;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CXX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYA0-1", "uniprot_id": "CREL2_MOUSE", "mass": 38220.0, "length": 350, "protein_name": "Protein disulfide isomerase Creld2", "gene_name": "Creld2", "organism": "Mouse", "refseq_name": "protein disulfide isomerase Creld2 precursor", "refseq_ac": "NP_083996", "gene_names_uniprotkb": "Creld2", "gene_names_refseq": "5730592L21Rik; Creld2", "protein_names_uniprotkb": "Protein disulfide isomerase Creld2; 5.3.4.1; Cysteine-rich with EGF-like domain protein 2", "protein_names_refseq": "cysteine-rich with EGF-like domain protein 2; protein disulfide isomerase Creld2 precursor; protein disulfide isomerase Creld2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76737)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19615339;21106106;23956175;24019898;26495903;28011936;30899004;31219806;34549824;39196188;40997131", "class_list": "", "function": "CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases., [RefSeq, PubMed]; Creld2 function during unfolded protein response is essential for liver metabolism homeostasis., [RefSeq, PubMed]; Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair., [RefSeq, PubMed]; Protein disulfide isomerase (Probable). Might play a role in the unfolded protein response (Probable). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results strongly suggest that Creld2 may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation Publication Status: Online-Only, [RefSeq, PubMed]; These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0035264 multicellular organism growth;GO:0006457 protein folding;GO:0060348 bone development;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CYA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ00-1", "uniprot_id": "DBND1_MOUSE", "mass": 17479.0, "length": 160, "protein_name": "Dysbindin domain-containing protein 1", "gene_name": "Dbndd1", "organism": "Mouse", "refseq_name": "dysbindin domain-containing protein 1 isoform 2", "refseq_ac": "NP_001164446", "gene_names_uniprotkb": "Dbndd1", "gene_names_refseq": "2810427I04Rik; D8Ertd590e; Dbndd1", "protein_names_uniprotkb": "Dysbindin domain-containing protein 1", "protein_names_refseq": "dysbindin (dystrobrevin binding protein 1) domain containing 1; dysbindin domain-containing protein 1 isoform 2; dysbindin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72185)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XJ9;Q8BMU4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZ00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBB8-1", "uniprot_id": "DHDH_MOUSE", "mass": 36301.0, "length": 333, "protein_name": "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase", "gene_name": "Dhdh", "organism": "Mouse", "refseq_name": "trans-1,2-dihydrobenzene-1,2-diol dehydrogenase", "refseq_ac": "NP_082179", "gene_names_uniprotkb": "Dhdh", "gene_names_refseq": "1300018L09Rik; B830008H07Rik; Dhdh; Xld-1; Xld1", "protein_names_uniprotkb": "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 1.1.1.-; 1.1.1.115; 1.1.1.119; 1.1.1.120; 1.1.1.179; 1.3.1.20; D-arabinose 1-dehydrogenase; D-galactose 1-dehydrogenase; D-glucose 1-dehydrogenase; D-ribose 1-dehydrogenase; D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Dimeric dihydrodiol dehydrogenase", "protein_names_refseq": "D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; dihydrodiol dehydrogenase (dimeric); dimeric dihydrodiol dehydrogenase; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; xylose dehydrogenase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71755)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26495903", "class_list": "", "function": "Catalyzes the NADP(+)-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols. It also catalyzes the oxidation of several pentoses and hexoses. In the reverse reaction in the presence of NADPH, it acts as NADPH-linked reductase on a broad range of substrates including aldehydes, chetones, and alpha-dicarbonyl compounds such as 3-deoxyglucosone, camphorquinone and methylglyoxal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B09", "ec_number_list": "3.1.1.31;1.1.1.47;1.1.1.363;1.1.1.-;1.3.1.20;1.1.1.179;1.1.1.115;1.1.1.119;1.1.1.120", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity", "go_cellular_component": "", "go_biological_process": "GO:0042843 D-xylose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DBB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBF7-1", "uniprot_id": "CWC25_MOUSE", "mass": 48811.0, "length": 416, "protein_name": "Pre-mRNA-splicing factor CWC25 homolog", "gene_name": "Cwc25", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor CWC25 homolog", "refseq_ac": "NP_080462", "gene_names_uniprotkb": "Cwc25; Ccdc49", "gene_names_refseq": "1300013D05Rik; Ccdc49; Cwc25", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC25 homolog; Coiled-coil domain-containing protein 49; Spliceosome-associated protein homolog CWC25", "protein_names_refseq": "CWC25 spliceosome-associated protein homolog; coiled-coil domain containing 49; coiled-coil domain-containing protein 49; pre-mRNA-splicing factor CWC25 homolog; spliceosome-associated protein homolog CWC25", "tax_id": 10090, "disease": "", "pathway": " (mmu:67480); (R-MMU-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6F4;Q6AXH2;Q7TSF8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DBF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBN9-1", "uniprot_id": "DDX59_MOUSE", "mass": 68234.0, "length": 619, "protein_name": "Probable ATP-dependent RNA helicase DDX59", "gene_name": "Ddx59", "organism": "Mouse", "refseq_name": "probable ATP-dependent RNA helicase DDX59", "refseq_ac": "NP_080776", "gene_names_uniprotkb": "Ddx59; Znhit5", "gene_names_refseq": "1210002B07Rik; 4833411G06Rik; Ddx59", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX59; 3.6.4.13; DEAD box protein 59; Zinc finger HIT domain-containing protein 5", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 59; DEAD box protein 59; probable ATP-dependent RNA helicase DDX59; zinc finger HIT domain-containing protein 5", "tax_id": 10090, "disease": "orofaciodigital syndrome V (Disease Ontology:DOID:0060375)", "pathway": " (mmu:67997)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;23972372", "class_list": "", "function": "These data strongly implicate DDX59 RNA helicase family member in the pathogenesis of orofaciodigital syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C667;Q9CSD1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPL2-1", "uniprot_id": "CSTN1_MOUSE", "mass": 108900.0, "length": 979, "protein_name": "Calsyntenin-1", "gene_name": "Clstn1", "organism": "Mouse", "refseq_name": "calsyntenin-1 isoform 2 precursor", "refseq_ac": "NP_001277918", "gene_names_uniprotkb": "Clstn1; Cs1; Cstn1; Kiaa0911", "gene_names_refseq": "1810034E21Rik; Clstn1; Cst-1; Cstn1", "protein_names_uniprotkb": "Calsyntenin-1; Alc-alpha; Alcadein-alpha; C-terminal fragment 1-alpha", "protein_names_refseq": "alc-alpha; alcadein alpha; calsyntenin-1 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:65945)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11161476;12498782;12972431;15037614;16760430;17332754;22872234;24613359;25428506;25605945;26495903;32467230;34428180;35279170;37585286", "class_list": "", "function": "Amyloidogenic processing of amyloid beta protein precursor (APP) is enhanced in the brains of alcadein alpha-deficient mice., [RefSeq, PubMed]; As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding., [UniProtKB, PubMed, PubMed]; Axonal transport of Frizzled5 by Alcadein alpha-containing vesicles is associated with kinesin-1., [RefSeq, PubMed]; In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP., [UniProtKB, PubMed, PubMed]; Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:11161476, PubMed:24613359). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:17332754). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:11161476, PubMed:12972431)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A800;B2KFP1;B2KFP2;Q69ZV9;Q7TS67;Q8K103", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding;GO:0019894 kinesin binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042988 X11-like protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0006874 intracellular calcium ion homeostasis;GO:0007268 chemical synaptic transmission;GO:0001558 regulation of cell growth;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EPL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER65-1", "uniprot_id": "CSTN2_MOUSE", "mass": 107887.0, "length": 966, "protein_name": "Calsyntenin-2", "gene_name": "Clstn2", "organism": "Mouse", "refseq_name": "calsyntenin-2 isoform 1 precursor", "refseq_ac": "NP_071714", "gene_names_uniprotkb": "Clstn2; Cs2; Cstn2; Kiaa4134", "gene_names_refseq": "2900042C18Rik; CSTN2; Clstn2; Cs2; Cst-2; mKIAA4134", "protein_names_uniprotkb": "Calsyntenin-2", "protein_names_refseq": "alc-gamma; alcadein-gamma; calsyntenin-2 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:64085)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12498782;22872234;24613359;26171716;28647593;30899004;31529526;34182007;35279170", "class_list": "", "function": "Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (PubMed:24613359, PubMed:26171716, PubMed:31529526). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Vocal and physical phenotypes of calsyntenin2 knockout mouse pups model early-life symptoms of the autism spectrum disorder., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTM0;Q6P565;Q8C858", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0008306 associative learning;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050806 positive regulation of synaptic transmission;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9ER65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHR6-1", "uniprot_id": "DPYD_MOUSE", "mass": 111253.0, "length": 1025, "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]", "gene_name": "Dpyd", "organism": "Mouse", "refseq_name": "dihydropyrimidine dehydrogenase [NADP(+)]", "refseq_ac": "NP_740748", "gene_names_uniprotkb": "Dpyd", "gene_names_refseq": "DHPDHase; DPD; Dpyd; E330028L06Rik", "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase", "protein_names_refseq": "dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase", "tax_id": 10090, "disease": "dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:99586); (R-MMU-73621)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12527935;17242355;21183079;21750661;25428506;30084848;30779550;34428180;34653361;37453647;40885482", "class_list": "", "function": "DPD gene expression is regulated first at the mRNA level when the hepatocytes enter the cell cycle. There is little regulation at the translational level. Cell proliferation rate is influences the enzyme activity modification., [RefSeq, PubMed]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil., [UniProtKB, UniProtKB]; The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.2", "go_molecular_function": "GO:0002058 uracil binding;GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006145 purine nucleobase catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CHR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXK5-1", "uniprot_id": "DUS11_MOUSE", "mass": 37851.0, "length": 321, "protein_name": "RNA/RNP complex-1-interacting phosphatase", "gene_name": "Dusp11", "organism": "Mouse", "refseq_name": "RNA/RNP complex-1-interacting phosphatase", "refseq_ac": "NP_082375", "gene_names_uniprotkb": "Dusp11; Pir1", "gene_names_refseq": "2010300F21Rik; Dusp11", "protein_names_uniprotkb": "RNA/RNP complex-1-interacting phosphatase; 3.1.3.-; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1", "protein_names_refseq": "RNA/RNP complex-1-interacting phosphatase; phosphatase that interacts with RNA/RNP complex 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22872234", "class_list": "", "function": "Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTR4;Q8BYE4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016791 phosphatase activity;GO:0004651 polynucleotide 5'-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0001650 fibrillar center;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NXK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KE3-1", "uniprot_id": "DOK4_MOUSE", "mass": 37040.0, "length": 325, "protein_name": "Docking protein 4", "gene_name": "Dok4", "organism": "Mouse", "refseq_name": "docking protein 4", "refseq_ac": "NP_444476", "gene_names_uniprotkb": "Dok4", "gene_names_refseq": "Dok4", "protein_names_uniprotkb": "Docking protein 4; Downstream of tyrosine kinase 4", "protein_names_refseq": "docking protein 4; downstream of tyrosine kinase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:114255); (R-MMU-8853659)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11470823;14963042;21750661;22982678;28275114;34428180", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity)., [UniProtKB]; Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization. Publication Status: Online-Only, [RefSeq, PubMed]; Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase signaling in epithelial cells., [RefSeq, PubMed]; The current study have explored in more detail the structure and function of the Dok-4 PTB domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0X3", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99KE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLI4-1", "uniprot_id": "DSE_MOUSE", "mass": 109755.0, "length": 958, "protein_name": "Dermatan-sulfate epimerase", "gene_name": "Dse", "organism": "Mouse", "refseq_name": "dermatan-sulfate epimerase precursor", "refseq_ac": "NP_766096", "gene_names_uniprotkb": "Dse; Sart2", "gene_names_refseq": "6030499O08; B130024B19Rik; DS-epi1; Dse; Sart2", "protein_names_uniprotkb": "Dermatan-sulfate epimerase; 5.1.3.19; Chondroitin-glucuronate 5-epimerase; DS epimerase; SART-2; Squamous cell carcinoma antigen recognized by T-cells 2", "protein_names_refseq": "DS epimerase; chondroitin-glucuronate 5-epimerase; dermatan-sulfate epimerase precursor; squamous cell carcinoma antigen recognized by T cells 2", "tax_id": 10090, "disease": "Ehlers-Danlos syndrome musculocontractural type 2 (Disease Ontology:DOID:0080737)", "pathway": " (mmu:212898); (R-MMU-2022923)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19687302;21750661;25186462;26488883;26495903;30084848;37828378", "class_list": "glycogene", "function": "Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate., [UniProtKB, UniProtKB]; DS-epi1-deficient mice show chondroitin sulfate /dermatan sulfate with a marked deficiency in iduronic acid-containing structures., [RefSeq, PubMed]; Data show that dermatan sulfate is completely absent in dermatan sulfate epimerase 1 and 2 double knockout (DKO) mice. Publication Status: Online-Only, [RefSeq, PubMed]; The combination of defective collagen structure in the dermis and imbalanced keratinocyte maturation could be responsible for the observed developmental defects in DS-epi1-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3U620", "ec_number_list": "5.1.-.-;5.1.3.19", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047757 chondroitin-glucuronate 5-epimerase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0050654 chondroitin sulfate proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BLI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YA7-1", "uniprot_id": "DPP8_MOUSE", "mass": 102186.0, "length": 892, "protein_name": "Dipeptidyl peptidase 8", "gene_name": "Dpp8", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 8", "refseq_ac": "NP_083182", "gene_names_uniprotkb": "Dpp8", "gene_names_refseq": "2310004I03Rik; 4932434F09Rik; DP8; DPP VIII; Dpp8", "protein_names_uniprotkb": "Dipeptidyl peptidase 8; 3.4.14.5; DP8; DPP VIII; Dipeptidyl peptidase VIII", "protein_names_refseq": "dipeptidyl peptidase 8; dipeptidyl peptidase VIII", "tax_id": 10090, "disease": "", "pathway": " (mmu:74388)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19581630;21750661;23704821;25428506;26242871;27820798;29396289;29693275;30084848;31219806;34428180", "class_list": "", "function": "Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; DP8 and DP9 tissue and cellular expression, [RefSeq, PubMed]; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (By similarity). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29396289). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (By similarity). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis., [RefSeq, PubMed]; The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4G6", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904784 NLRP1 inflammasome complex assembly;GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0051604 protein maturation;GO:0140633 CARD8 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80YA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921R4-1", "uniprot_id": "DJC14_MOUSE", "mass": 78919.0, "length": 703, "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "Dnajc14", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 14", "refseq_ac": "NP_083149", "gene_names_uniprotkb": "Dnajc14", "gene_names_refseq": "5730551F12Rik; DNAJ; DRIP78; Dnajc14; HDJ3; LIP6", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 14", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 14; dnaJ homolog subfamily C member 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:74330)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29540721", "class_list": "", "function": "Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface., [UniProtKB]; The study indicates that DRiP78 levels are elevated in mice that express higher general cognitive ability, raising the possibility that a larger pool of sequestered D1 receptors is available for insertion into the membrane in response to cognitive demands. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX73;Q8BUU3;Q9CYB7", "ec_number_list": "", "go_molecular_function": "GO:0050780 dopamine receptor binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q921R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61616-1", "uniprot_id": "DRD1_MOUSE", "mass": 49612.0, "length": 446, "protein_name": "D(1A) dopamine receptor", "gene_name": "Drd1", "organism": "Mouse", "refseq_name": "D(1A) dopamine receptor", "refseq_ac": "NP_001278730", "gene_names_uniprotkb": "Drd1; Drd1a; Gpcr15", "gene_names_refseq": "C030036C15Rik; Drd-1; Drd1a; Drd1; Gpcr15", "protein_names_uniprotkb": "D(1A) dopamine receptor; Dopamine D1 receptor", "protein_names_refseq": "D(1A) dopamine receptor; D1A dopamine receptor; G protein-coupled receptor DRD1; dopamine D1 receptor; dopamine receptor D1A", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); tracheal stenosis (Disease Ontology:DOID:3227); hyperglycemia (Disease Ontology:DOID:4195); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13488); (R-MMU-390651); (R-MMU-418555)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11901220;21183079;21750661;25865831;35820727;37248637;40523512;8288218", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RPW8;Q8C8P8", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0051117 ATPase binding;GO:0032795 heterotrimeric G-protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0030432 peristalsis;GO:0046959 habituation;GO:0042321 negative regulation of circadian sleep/wake cycle, sleep;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0035106 operant conditioning", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q61616-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0D4-1", "uniprot_id": "DIM1_MOUSE", "mass": 35274.0, "length": 313, "protein_name": "Dimethyladenosine transferase", "gene_name": "Dimt1", "organism": "Mouse", "refseq_name": "dimethyladenosine transferase", "refseq_ac": "NP_079723", "gene_names_uniprotkb": "Dimt1; Dimt1l", "gene_names_refseq": "1500031M22Rik; Dimt1l; Dimt1", "protein_names_uniprotkb": "Dimethyladenosine transferase; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; 2.1.1.183; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase", "protein_names_refseq": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase; 18S rRNA dimethylase; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; dimethyladenosine transferase; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase; probable 18S rRNA dimethylase; probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; probable dimethyladenosine transferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66254)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;29187734", "class_list": "", "function": "Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTJ5;Q8BVH8", "ec_number_list": "2.1.1.183", "go_molecular_function": "GO:0003723 RNA binding;GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032040 small-subunit processome", "go_biological_process": "GO:0031167 rRNA methylation;GO:2000234 positive regulation of rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D0D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK84-1", "uniprot_id": "DUS29_MOUSE", "mass": 24192.0, "length": 215, "protein_name": "Dual specificity phosphatase 29", "gene_name": "Dusp29", "organism": "Mouse", "refseq_name": "dual specificity phosphatase 29", "refseq_ac": "NP_001013848", "gene_names_uniprotkb": "Dusp29; Dupd1; Dusp27", "gene_names_refseq": "Dupd1; Dusp29; EG435391", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "dual specificity phosphatase 29; dual specificity phosphatase DUPD1; dual specificity phosphatase and pro isomerase domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:435391)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17498703;21750661;30201684;32639872", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (PubMed:30201684). Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (PubMed:32639872)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RW26", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0042692 muscle cell differentiation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BK84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A9I7-1", "uniprot_id": "DMRTB_MOUSE", "mass": 38424.0, "length": 359, "protein_name": "Doublesex- and mab-3-related transcription factor B1", "gene_name": "Dmrtb1", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor B1", "refseq_ac": "NP_063925", "gene_names_uniprotkb": "Dmrtb1; Dmrt6", "gene_names_refseq": "Dmrt6; Dmrtb1; Prp13", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor B1; Doublesex- and mab-3-related transcription factor 6", "protein_names_refseq": "doublesex and mab-3 related transcription factor 6; doublesex- and mab-3-related transcription factor B1; proline-rich protein 13", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:56296)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12609607;21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGW8", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2A9I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ALW5-1", "uniprot_id": "DJC25_MOUSE", "mass": 41937.0, "length": 357, "protein_name": "DnaJ homolog subfamily C member 25", "gene_name": "Dnajc25", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 25 precursor", "refseq_ac": "NP_001028337", "gene_names_uniprotkb": "Dnajc25", "gene_names_refseq": "2010109C08Rik; 2010203O07Rik; Dnajc25", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 25", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 25; dnaJ homolog subfamily C member 25 precursor; dnaJ homolog subfamily C member 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:72429)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22872234;31219806;34428180;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALW4;Q0VBC8;Q3UWH0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2ALW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62627-1", "uniprot_id": "DLRB1_MOUSE", "mass": 10990.0, "length": 96, "protein_name": "Dynein light chain roadblock-type 1", "gene_name": "Dynlrb1", "organism": "Mouse", "refseq_name": "dynein light chain roadblock-type 1 isoform b", "refseq_ac": "NP_080223", "gene_names_uniprotkb": "Dynlrb1; Dncl2a; Dnlc2a", "gene_names_refseq": "2010012N15Rik; 2010320M17Rik; 9430076K19Rik; DNLC2A; Dncl2a; Dynlrb1; km23-1", "protein_names_uniprotkb": "Dynein light chain roadblock-type 1; Dynein light chain 2A, cytoplasmic", "protein_names_refseq": "dynein light chain 2A, cytoplasmic; dynein light chain roadblock-type 1 isoform b; dynein, cytoplasmic, light chain 2A; dynein, cytoplasmic, light polypeptide 2A", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:67068); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14752807;16289575;17346231;21750661;32796833;34428180;36288343;36973253", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules., [UniProtKB, UniProtKB]; Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Publication Status: Online-Only, [RefSeq, PubMed]; N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Publication Status: Online-Only, [RefSeq, PubMed]; The presence of an N-terminal tag on dynein light-chain Roadblock/LC7 affects its interaction with a functional partner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVR8;O88567;Q4FZJ8;Q9D812", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0007632 visual behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KFU9-1", "uniprot_id": "DISP3_MOUSE", "mass": 148446.0, "length": 1347, "protein_name": "Protein dispatched homolog 3", "gene_name": "Disp3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Disp3; Kiaa1337; Ptchd2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein dispatched homolog 3; Patched domain-containing protein 2; RND-type protein RNDEu-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:242748)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;19179482;21750661;25428506", "class_list": "", "function": "Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q0EEE3;Q69ZL6;Q6GQX3;Q6NS63", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0030154 cell differentiation;GO:0045665 negative regulation of neuron differentiation;GO:2000179 positive regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A3KFU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYC5-1", "uniprot_id": "DSN1_MOUSE", "mass": 39553.0, "length": 348, "protein_name": "Kinetochore-associated protein DSN1 homolog", "gene_name": "Dsn1", "organism": "Mouse", "refseq_name": "kinetochore-associated protein DSN1 homolog", "refseq_ac": "NP_080129", "gene_names_uniprotkb": "Dsn1", "gene_names_refseq": "1700022L09Rik; Dsn1", "protein_names_uniprotkb": "Kinetochore-associated protein DSN1 homolog", "protein_names_refseq": "DSN1, MIND kinetochore complex component, homolog; kinetochore-associated protein DSN1 homolog", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66934); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-6798695); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "21183079;21750661;23861669", "class_list": "", "function": "Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis., [UniProtKB, UniProtKB]; We demonstrate that interaction of monopolin subunit Csm1 with the N-terminal domain of MIND complex subunit Dsn1, is essential for both the association of monopolin with kinetochores and for monopolar attachment of sister kinetochores during meiosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYF2;Q9DA26", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0014841 skeletal muscle satellite cell proliferation;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CYC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V91-1", "uniprot_id": "DTX3_MOUSE", "mass": 37982.0, "length": 347, "protein_name": "E3 ubiquitin-protein ligase DTX3", "gene_name": "Dtx3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DTX3 isoform 1", "refseq_ac": "NP_109639", "gene_names_uniprotkb": "Dtx3", "gene_names_refseq": "Deltex3; Dtx3; mg310", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX3; 2.3.2.27; Deltex3; Protein deltex-3; RING-type E3 ubiquitin transferase DTX3; mDTX3", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX3 isoform 1; RING-type E3 ubiquitin transferase DTX3; deltex 3 homolog; mDTX3; probable E3 ubiquitin-protein ligase DTX3; protein deltex-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:80904)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11226752;21750661;34428180", "class_list": "", "function": "Functions as an ubiquitin ligase protein, and regulates Notch signaling. By promoting the ubiquitination and subsequent degradation of target proteins, it can block activation of the Notch signaling pathway, potentially acting as a tumor suppressor in human cancers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZD3;Q9ER06", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80V91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCE1-1", "uniprot_id": "DJC28_MOUSE", "mass": 44873.0, "length": 385, "protein_name": "DnaJ homolog subfamily C member 28", "gene_name": "Dnajc28", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 28 isoform 2", "refseq_ac": "NP_619605", "gene_names_uniprotkb": "Dnajc28; ORF28", "gene_names_refseq": "Dnajc28; ORF28", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 28", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 28; dnaJ homolog subfamily C member 28 isoform 2; dnaJ homolog subfamily C member 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:246738)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May have a role in protein folding or as a chaperone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JX0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6F1-1", "uniprot_id": "DYH2_MOUSE", "mass": 511565.0, "length": 4456, "protein_name": "Dynein axonemal heavy chain 2", "gene_name": "Dnah2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dnah2; Dnahc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 2; Axonemal beta dynein heavy chain 2; Ciliary dynein heavy chain 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "spermatogenic failure 45 (Disease Ontology:DOID:0112163)", "pathway": " (mmu:327954)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22872234;25428506;30060180;30084848;34428180;9373155", "class_list": "", "function": "As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30060180). Expressed in sperm flagellum, it is required for sperm motility (By similarity). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30060180)., [UniProtKB, UniProtKB, PubMed]; As part of the axonemal inner dynein arm complex plays a central role in ciliary beat. Expressed in sperm flagellum, it is required for sperm motility. Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AR18;O08826;Q8C0U5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly;GO:0060285 cilium-dependent cell motility;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0C6F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q8D0-1", "uniprot_id": "DJC21_MOUSE", "mass": 61735.0, "length": 531, "protein_name": "DnaJ homolog subfamily C member 21", "gene_name": "Dnajc21", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 21", "refseq_ac": "NP_084322", "gene_names_uniprotkb": "Dnajc21", "gene_names_refseq": "4930461P20Rik; 9930116P15Rik; Dnajc21", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 21", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 21; dnaJ homolog subfamily C member 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:78244)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17242355;21183079", "class_list": "", "function": "May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USP3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q8D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97399-1", "uniprot_id": "DSPP_MOUSE", "mass": 93903.0, "length": 934, "protein_name": "Dentin sialophosphoprotein", "gene_name": "Dspp", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dspp; Dmp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Dentin sialophosphoprotein; DMP-3; DPP; Dentin matrix protein 3; Dentin phosphophoryn", "protein_names_refseq": "", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476); periodontal disease (Disease Ontology:DOID:3388); dentinogenesis imperfecta (Disease Ontology:DOID:4154)", "pathway": " (mmu:666279); (R-MMU-3000178)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11175790;17699513;21750661;24028588;8995371;9395101;9545272", "class_list": "", "function": "DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O70567", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0097187 dentinogenesis;GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:1903011 negative regulation of bone development;GO:0042476 odontogenesis;GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97399-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50172-1", "uniprot_id": "DHI1_MOUSE", "mass": 32364.0, "length": 292, "protein_name": "11-beta-hydroxysteroid dehydrogenase 1", "gene_name": "Hsd11b1", "organism": "Mouse", "refseq_name": "11-beta-hydroxysteroid dehydrogenase 1 isoform 1", "refseq_ac": "NP_001038216", "gene_names_uniprotkb": "Hsd11b1; Hsd11", "gene_names_refseq": "Hsd11b1", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase 1; 1.1.1.146; 1.1.1.201; 11-DH; 11-beta-HSD1A/MCR; 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase; 11beta-HSD1A; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1; liver-type 11-beta-HSD", "protein_names_refseq": "11-beta-HSD1A/MCR; 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1 isoform 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase; 11beta-HSD-1; 11beta-HSD1A; 11beta-hydroxysteroid dehydrogenase type 1; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); corticosteroid 11-beta-dehydrogenase isozyme 1; liver-type 11-beta-HSD", "tax_id": 10090, "disease": "cortisone reductase deficiency (Disease Ontology:DOID:0090139); cortisone reductase deficiency 2 (Disease Ontology:DOID:0090140); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); status epilepticus (Disease Ontology:DOID:1824); coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15483); (R-MMU-194002); (R-MMU-9757110)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;15865440;21750661;23415904;30084848;30899004;30902677;34428180;36210013;37453647;38805506;39302000;39362888;40885482;7851387;7873449;8973338;9405715", "class_list": "", "function": "Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:23415904, PubMed:30902677, PubMed:9405715). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (PubMed:9405715). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:23415904). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:23415904). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:23415904). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Deletion of Hsd11b1 suppresses caloric restriction-induced bone marrow adiposity in male but not female mice. Publication Status: Online-Only, [RefSeq, PubMed]; Glucocorticoid excess alters metabolic rate and substrate utilisation via 11beta-HSD1. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting osteoblastic 11beta-HSD1 to combat high-fat diet-induced bone loss and obesity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.146;1.1.1.201;1.1.1.-", "go_molecular_function": "GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0050661 NADP binding;GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043456 regulation of pentose-phosphate shunt;GO:0006713 glucocorticoid catabolic process;GO:0030324 lung development;GO:0006704 glucocorticoid biosynthetic process;GO:0006706 steroid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P50172-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0B3-1", "uniprot_id": "DHR11_MOUSE", "mass": 28274.0, "length": 260, "protein_name": "Dehydrogenase/reductase SDR family member 11", "gene_name": "Dhrs11", "organism": "Mouse", "refseq_name": "dehydrogenase/reductase SDR family member 11 precursor", "refseq_ac": "NP_808232", "gene_names_uniprotkb": "Dhrs11; Sdr24c1", "gene_names_refseq": "Dhrs11", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 11; 1.1.1.270; 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; Estradiol 17-beta-dehydrogenase; Short-chain dehydrogenase/reductase family 24C member 1", "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; dehydrogenase/reductase (SDR family) member 11; dehydrogenase/reductase SDR family member 11 precursor; estradiol 17-beta-dehydrogenase; short-chain dehydrogenase/reductase family 24C member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192970)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SXB3;Q8R249", "ec_number_list": "1.1.1.330;1.1.1.62;1.1.1.270;1.1.1.210;1.1.1.145;5.3.3.1;1.1.1.51;1.1.1.64;1.3.1.3;1.1.1.239;1.1.1.105;1.1.1.209;1.1.1.53", "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0000166 nucleotide binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U0B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZF0-1", "uniprot_id": "DJC24_MOUSE", "mass": 16922.0, "length": 148, "protein_name": "DnaJ homolog subfamily C member 24", "gene_name": "Dnajc24", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 24", "refseq_ac": "NP_081268", "gene_names_uniprotkb": "Dnajc24; Dph4; Zcsl3", "gene_names_refseq": "1700030A21Rik; 2610027M02Rik; Dnajc24; Dph4; MmDjC7; Zcsl3", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 24; CSL-type zinc finger-containing protein 3; Diphthamide biosynthesis protein 4; J domain protein DjC7", "protein_names_refseq": "CSL-type zinc finger-containing protein 3; DPH4 homolog (JJJ3, S. cerevisiae); DnaJ (Hsp40) homolog, subfamily C, member 24; diphthamide biosynthesis protein 4; dnaJ homolog subfamily C member 24; j domain protein DjC7; zinc finger, CSL-type containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:99349); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11595173;18765564;21750661;35820727", "class_list": "", "function": "A mouse that was mutant for the gene, Dph4, was identified., [RefSeq, PubMed]; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9S7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0001671 ATPase activator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032781 positive regulation of ATP-dependent activity;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70152-1", "uniprot_id": "DPM1_MOUSE", "mass": 29175.0, "length": 260, "protein_name": "Dolichol-phosphate mannosyltransferase subunit 1", "gene_name": "Dpm1", "organism": "Mouse", "refseq_name": "dolichol-phosphate mannosyltransferase subunit 1 isoform 2", "refseq_ac": "NP_001297013", "gene_names_uniprotkb": "Dpm1", "gene_names_refseq": "Dpm1", "protein_names_uniprotkb": "Dolichol-phosphate mannosyltransferase subunit 1; 2.4.1.83; DPM synthase subunit 1; Dolichol-phosphate mannose synthase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; MPD synthase; Mannose-P-dolichol synthase subunit 1", "protein_names_refseq": "DPM synthase subunit 1; MPD synthase; dolichol-phosphate (beta-D) mannosyltransferase 1; dolichol-phosphate mannose synthase subunit 1; dolichol-phosphate mannosyltransferase subunit 1 isoform 2; dolichyl-phosphate beta-D-mannosyltransferase subunit 1; mannose-P-dolichol synthase subunit 1", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ie (Disease Ontology:DOID:0080557)", "pathway": " (mmu:13480); (R-MMU-162699)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;26495903;29187734;30084848;34428180;37453647;37828378;9535917", "class_list": "glycogene;glycosyltransferase", "function": "Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D829", "ec_number_list": "2.4.1.83", "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006506 GPI anchor biosynthetic process;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0T2-1", "uniprot_id": "DUS12_MOUSE", "mass": 37159.0, "length": 339, "protein_name": "Dual specificity protein phosphatase 12", "gene_name": "Dusp12", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 12 isoform 1", "refseq_ac": "NP_075662", "gene_names_uniprotkb": "Dusp12", "gene_names_refseq": "1190004O14Rik; Dusp12; ESTM36; LMW-DSP4; T-DSP4; VH1; mVH1", "protein_names_uniprotkb": "Dual specificity protein phosphatase 12; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase T-DSP4; Dual specificity phosphatase VH1", "protein_names_refseq": "dual specificity phosphatase T-DSP4; dual specificity phosphatase VH1; dual specificity protein phosphatase 12 isoform 1; dual specificity protein phosphatase 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:80915)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11130991;21750661;27702885;31219806;32803262;33416082;36108935;38721693", "class_list": "", "function": "DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway., [RefSeq, PubMed]; DUSP12 protects against hepatic ischemia-reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo., [RefSeq, PubMed]; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dual-specificity phosphatase 12 attenuates oxidative stress injury and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38 signaling pathway., [RefSeq, PubMed]; Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway., [RefSeq, PubMed]; The regulatory role of DUSP12 is primarily through c-Jun N-terminal kinase (JNK) inhibition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQD3", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019900 kinase binding;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D0T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZY3-1", "uniprot_id": "DPPA3_MOUSE", "mass": 17670.0, "length": 150, "protein_name": "Developmental pluripotency-associated protein 3", "gene_name": "Dppa3", "organism": "Mouse", "refseq_name": "developmental pluripotency-associated protein 3", "refseq_ac": "NP_631964", "gene_names_uniprotkb": "Dppa3; Cap1p; Crg1; Pgc7", "gene_names_refseq": "2410075G02Rik; Dppa3; PCG7; PGC7; Stella", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 3; Compaction-associated protein 1; Primordial germ cell protein 7; Stella", "protein_names_refseq": "compaction-associated protein 1; developmental pluripotency-associated protein 3; primordial germ cell 7; primordial germ cell protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:73708)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11900980;12124616;12620990;14654002;14684992;15018652;17143267;21407207;21750661;22034526;22722204", "class_list": "glycogene", "function": "Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6S6F5", "ec_number_list": "", "go_molecular_function": "GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001939 female pronucleus", "go_biological_process": "GO:0040016 embryonic cleavage;GO:0044726 epigenetic programing of female pronucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8QZY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55111-1", "uniprot_id": "DSG2_MOUSE", "mass": 122385.0, "length": 1122, "protein_name": "Desmoglein-2", "gene_name": "Dsg2", "organism": "Mouse", "refseq_name": "desmoglein-2 preproprotein", "refseq_ac": "NP_031909", "gene_names_uniprotkb": "Dsg2", "gene_names_refseq": "D18Ertd293e; Dsg2", "protein_names_uniprotkb": "Desmoglein-2", "protein_names_refseq": "desmoglein-2 preproprotein", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); arrhythmogenic right ventricular dysplasia 10 (Disease Ontology:DOID:0110081); dilated cardiomyopathy 1BB (Disease Ontology:DOID:0110458); dilated cardiomyopathy (Disease Ontology:DOID:12930); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:13511); (R-MMU-351906); (R-MMU-6805567); (R-MMU-6809371); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11222147;12494996;12787123;19349973;19635863;21183079;26085008;26495903;27338829;29910125;30059200;34428180;34678516;35820727;36268721;36309486;36852467;37507081;38395410;39227800;9404003;9864371", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (PubMed:12494996). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (By similarity). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Promotes cardiomyocyte cell homeostasis and desmosome junction formation at intercalated disks, as a result plays a role in the maintenance of cardiac conduction and heart chamber integrity (PubMed:19635863, PubMed:26085008, PubMed:36268721). Positively regulates pancreatic islet development and maintenance of endothelial cell barrier integrity in the pancreas, therefore involved in the controlled release of insulin from islet cells into the circulation in response to glucose (PubMed:36309486). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). Acts as a positive modulator of CSK and EGFR activation via sequestering them away from lipid rafts, this is independent of its role in desmosome cell junctions (By similarity). Also disrupts the localization of CAV1 to lipid rafts resulting in its distribution throughout the cytoplasm (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Hyperactivation of ATF4/TGF-beta1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 6, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A2RRJ0;Q8K069;Q8R517", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030054 cell junction;GO:0014704 intercalated disc", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:1902459 positive regulation of stem cell population maintenance;GO:0007155 cell adhesion;GO:0043066 negative regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "O55111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55188-1", "uniprot_id": "DMP1_MOUSE", "mass": 53965.0, "length": 503, "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "Dmp1", "organism": "Mouse", "refseq_name": "dentin matrix acidic phosphoprotein 1 precursor", "refseq_ac": "NP_058059", "gene_names_uniprotkb": "Dmp1; Dmp", "gene_names_refseq": "AG1; DMP-1; Dmp1; Dmp; PP", "protein_names_uniprotkb": "Dentin matrix acidic phosphoprotein 1; AG1; DMP-1; Dentin matrix protein 1", "protein_names_refseq": "dentin matrix acidic phosphoprotein 1 precursor; dentin matrix acidic phosphoprotein 1; serine rich acidic phosphoprotein", "tax_id": 10090, "disease": "autosomal recessive hypophosphatemic rickets (Disease Ontology:DOID:0050949)", "pathway": " (mmu:13406); (R-MMU-3000178); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "17033621;24028588;26634432;28822114;29148101;9525343", "class_list": "", "function": "May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZB6", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0070173 regulation of enamel mineralization;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0031214 biomineral tissue development;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70566-1", "uniprot_id": "DIAP2_MOUSE", "mass": 124871.0, "length": 1098, "protein_name": "Protein diaphanous homolog 2", "gene_name": "Diaph2", "organism": "Mouse", "refseq_name": "protein diaphanous homolog 2 isoform X2", "refseq_ac": "XP_006528645", "gene_names_uniprotkb": "Diaph2; Diap2", "gene_names_refseq": "Dia3; Diap2; Diaph2; Drf2; E430022I22Rik", "protein_names_uniprotkb": "Protein diaphanous homolog 2; DRF2; Diaphanous-related formin-2; mDia3", "protein_names_refseq": "protein diaphanous homolog 2 isoform X2", "tax_id": 10090, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); primary ovarian insufficiency 2A (Disease Ontology:DOID:0080858); microcephaly (Disease Ontology:DOID:10907); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (R-MMU-5663220); (R-MMU-9035034)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15311282;25428506;27802388;30084848;31219806;34428180;36210013;9497258", "class_list": "", "function": "May be involved in oogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2G8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005884 actin filament", "go_biological_process": "GO:0016199 axon midline choice point recognition;GO:0048013 ephrin receptor signaling pathway;GO:0008104 intracellular protein localization;GO:0030041 actin filament polymerization;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88516-1", "uniprot_id": "DLL3_MOUSE", "mass": 62069.0, "length": 592, "protein_name": "Delta-like protein 3", "gene_name": "Dll3", "organism": "Mouse", "refseq_name": "delta-like protein 3 precursor", "refseq_ac": "NP_031892", "gene_names_uniprotkb": "Dll3", "gene_names_refseq": "Dll3; pudgy; pu", "protein_names_uniprotkb": "Delta-like protein 3; Delta3; Drosophila Delta homolog 3; M-Delta-3", "protein_names_refseq": "M-Delta-3; delta-like 3; delta-like protein 3 precursor; delta-like protein 3; delta3; drosophila Delta homolog 3", "tax_id": 10090, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (mmu:13389)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "38252118;9272948;9662403", "class_list": "", "function": "Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm., [UniProtKB]; Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35675;Q80W06;Q9QWL9;Q9QWZ7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0001501 skeletal system development;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28078-1", "uniprot_id": "DMA_MOUSE", "mass": 28950.0, "length": 261, "protein_name": "Class II histocompatibility antigen, M alpha chain", "gene_name": "H2-DMa", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-DMa; H2-Ma; Ma", "gene_names_refseq": "", "protein_names_uniprotkb": "Class II histocompatibility antigen, M alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-2132295)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1922366;21750661;37828378;9768758", "class_list": "", "function": "Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0015031 protein transport;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002636 positive regulation of germinal center formation;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28078-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28843-1", "uniprot_id": "DPP4_MOUSE", "mass": 87437.0, "length": 760, "protein_name": "Dipeptidyl peptidase 4", "gene_name": "Dpp4", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 4 isoform 2", "refseq_ac": "NP_001153015", "gene_names_uniprotkb": "Dpp4; Cd26", "gene_names_refseq": "Cd26; Dpp-4; Dpp4; THAM", "protein_names_uniprotkb": "Dipeptidyl peptidase 4; 3.4.14.5; DPP IV; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase IV; T-cell activation antigen CD26; THAM; Thymocyte-activating molecule", "protein_names_refseq": "DPP IV; T-cell activation antigen CD26; dipeptidyl peptidase 4 isoform 2; dipeptidyl peptidase IV; thymocyte-activating molecule", "tax_id": 10090, "disease": "Middle East respiratory syndrome (Disease Ontology:DOID:0080642); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:13482); (R-MMU-381771); (R-MMU-400511)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;1370813;1712807;19349973;26495903;26740625;28011936;29187734;32123820;32152506;34428180;37453647;39627609;7999781", "class_list": "glycogene", "function": "Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3U514", "ec_number_list": "3.4.14.5", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045121 membrane raft", "go_biological_process": "GO:0002717 positive regulation of natural killer cell mediated immunity;GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P28843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33611-1", "uniprot_id": "DPOA2_MOUSE", "mass": 66214.0, "length": 600, "protein_name": "DNA polymerase alpha subunit B", "gene_name": "Pola2", "organism": "Mouse", "refseq_name": "DNA polymerase alpha subunit B isoform 1", "refseq_ac": "NP_032919", "gene_names_uniprotkb": "Pola2", "gene_names_refseq": "Pola2", "protein_names_uniprotkb": "DNA polymerase alpha subunit B; DNA polymerase alpha 70 kDa subunit", "protein_names_refseq": "DNA polymerase alpha 2, 68 kDa; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit B isoform 1; DNA polymerase alpha subunit B", "tax_id": 10090, "disease": "", "pathway": " (mmu:18969); (R-MMU-113501); (R-MMU-174411); (R-MMU-174430); (R-MMU-68952); (R-MMU-68962); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;31219806;34428180;40885482;8463324", "class_list": "", "function": "Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDR3", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P33611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35737-1", "uniprot_id": "DMB_MOUSE", "mass": 28899.0, "length": 261, "protein_name": "Class II histocompatibility antigen, M beta 1 chain", "gene_name": "H2-DMb1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-DMb1; H-2Mb1; Mb", "gene_names_refseq": "", "protein_names_uniprotkb": "Class II histocompatibility antigen, M beta 1 chain; H2-M beta 1 chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:14999); (R-MMU-2132295)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1922366;21750661;34428180;7584146;8575819", "class_list": "", "function": "Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0006457 protein folding;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51436-1", "uniprot_id": "DRD4_MOUSE", "mass": 41487.0, "length": 387, "protein_name": "D(4) dopamine receptor", "gene_name": "Drd4", "organism": "Mouse", "refseq_name": "D(4) dopamine receptor isoform 1", "refseq_ac": "NP_031904", "gene_names_uniprotkb": "Drd4", "gene_names_refseq": "D4R; Drd-4; Drd4", "protein_names_uniprotkb": "D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor", "protein_names_refseq": "D(4) dopamine receptor isoform 1; d(2C) dopamine receptor; d(4) dopamine receptor; dopamine receptor 4", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); pervasive developmental disorder (Disease Ontology:DOID:0060040); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); opioid abuse (Disease Ontology:DOID:11206); pathological gambling (Disease Ontology:DOID:12399); conduct disorder (Disease Ontology:DOID:12995); alcohol use disorder (Disease Ontology:DOID:1574); substance abuse (Disease Ontology:DOID:302); dyslexia (Disease Ontology:DOID:4428); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); cannabis abuse (Disease Ontology:DOID:9505); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:13491); (R-MMU-390651); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18303015;24048828;30084848;37103560;7698326;8584230", "class_list": "", "function": "Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells. Erratum:[Pflugers Arch. 2023 Jun;475(6):775. doi: 10.1007/s00424-023-02819-7. PMID: 37138189], [RefSeq, PubMed]; Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (By similarity). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (PubMed:24048828)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35838;Q7TT80;Q8BXS4", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0034776 response to histamine;GO:0050709 negative regulation of protein secretion;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0060406 positive regulation of penile erection;GO:0098828 modulation of inhibitory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55292-1", "uniprot_id": "DSC2_MOUSE", "mass": 99961.0, "length": 902, "protein_name": "Desmocollin-2", "gene_name": "Dsc2", "organism": "Mouse", "refseq_name": "desmocollin-2 isoform Dsc2a preproprotein", "refseq_ac": "NP_001304294", "gene_names_uniprotkb": "Dsc2; Dsc3", "gene_names_refseq": "Dsc2", "protein_names_uniprotkb": "Desmocollin-2; Epithelial type 2 desmocollin", "protein_names_refseq": "desmocollin-2 isoform Dsc2a preproprotein; epithelial type 2 desmocollin", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 11 (Disease Ontology:DOID:0110082); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (mmu:13506); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;26763450;27033150;30084848;31967937;33596089;34428180;35820727;38395410;7711832;7959727;9864371", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (By similarity). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (PubMed:26763450)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the desmocollin protein subfamily. Desmocollins are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q64734", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0014704 intercalated disc;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0086091 regulation of heart rate by cardiac conduction;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:1900745 positive regulation of p38MAPK cascade;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P55292-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55849-1", "uniprot_id": "DSC1_MOUSE", "mass": 98938.0, "length": 886, "protein_name": "Desmocollin-1", "gene_name": "Dsc1", "organism": "Mouse", "refseq_name": "desmocollin-1 isoform 1 preproprotein", "refseq_ac": "NP_001278733", "gene_names_uniprotkb": "Dsc1", "gene_names_refseq": "1110020A10Rik; Dsc1", "protein_names_uniprotkb": "Desmocollin-1", "protein_names_refseq": "desmocollin-1 isoform 1 preproprotein", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431)", "pathway": " (mmu:13505); (R-MMU-6798695); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11714727;16170054;21750661;31302121;34428180;38395410;8823356", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:11714727). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (PubMed:11714727). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (PubMed:11714727)., [UniProtKB, PubMed]; Depot-medroxyprogesterone acetate reduces genital cell-cell adhesion molecule expression and increases genital herpes simplex virus type 2 infection susceptibility in a dose-dependent fashion., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epidermal fragility together with defects of epidermal barrier and differentiation. The neonatal mice lacking the encoded protein exhibit epidermal lesions and older mice develop chronic dermatitis. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QJX2", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0061436 establishment of skin barrier;GO:0050680 negative regulation of epithelial cell proliferation;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59041-1", "uniprot_id": "DJC30_MOUSE", "mass": 24762.0, "length": 219, "protein_name": "DnaJ homolog subfamily C member 30, mitochondrial", "gene_name": "Dnajc30", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 30, mitochondrial precursor", "refseq_ac": "NP_079638", "gene_names_uniprotkb": "Dnajc30; Wbscr18", "gene_names_refseq": "1300007M11Rik; Dnajc30; Wbscr18", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 30, mitochondrial; Williams-Beuren syndrome chromosomal region 18 protein homolog", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 30; Williams-Beuren syndrome chromosome region 18 homolog; Williams-Beuren syndrome critical region 18; dnaJ homolog subfamily C member 30, mitochondrial precursor; dnaJ homolog subfamily C member 30, mitochondrial; williams-Beuren syndrome chromosomal region 18 protein homolog", "tax_id": 10090, "disease": "chromosomal deletion syndrome (Disease Ontology:DOID:0060388); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:66114)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12073013;30318146;31219806", "class_list": "", "function": "DNAJC30 is an auxiliary component of ATP-synthase machinery. Removal of Dnajc30 in mice resulted in phenotype reminiscent of Williams syndrome., [RefSeq, PubMed]; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (PubMed:30318146). Associates with the ATP synthase complex and facilitates ATP synthesis (PubMed:30318146). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0007420 brain development;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70436-1", "uniprot_id": "DLX4_MOUSE", "mass": 26579.0, "length": 240, "protein_name": "Homeobox protein DLX-4", "gene_name": "Dlx4", "organism": "Mouse", "refseq_name": "homeobox protein DLX-4", "refseq_ac": "NP_031893", "gene_names_uniprotkb": "Dlx4; Dlx7", "gene_names_refseq": "Dlx-4; Dlx4; Dlx7", "protein_names_uniprotkb": "Homeobox protein DLX-4; Homeobox protein DLX-7", "protein_names_refseq": "DII D; distal-less homeo box 7; homeobox protein DLX-4; homeobox protein DLX-7", "tax_id": 10090, "disease": "orofacial cleft 15 (Disease Ontology:DOID:0080408)", "pathway": " (mmu:13394)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11792834;20173027;25954033;8975708", "class_list": "", "function": "May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM51;Q8R4I3", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P85965-1", "uniprot_id": "DPA5B_MOUSE", "mass": 13948.0, "length": 119, "protein_name": "Developmental pluripotency-associated protein 5B/5C", "gene_name": "Dppa5b; Dppa5c", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dppa5b; Dppa5c", "gene_names_refseq": "", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 5B/5C", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17913455", "class_list": "", "function": "Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97386-1", "uniprot_id": "DNLI3_MOUSE", "mass": 113072.0, "length": 1015, "protein_name": "DNA ligase 3", "gene_name": "Lig3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lig3", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA ligase 3; 6.5.1.1; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 20 (Disease Ontology:DOID:0070451); pancreatic cancer (Disease Ontology:DOID:1793); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (R-MMU-110381); (R-MMU-5649702); (R-MMU-5685939); (R-MMU-6782210)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "17242355;19144319;21183079;21750661;28528544;31219806;36852467;9001252", "class_list": "", "function": "The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QL81;P97385", "ec_number_list": "3.6.4.-;5.6.2.3;3.1.13.-;2.7.7.48;2.7.7.6;6.5.1.1;5.6.2.4;2.7.7.7;3.1.11.-;2.3.2.27;2.3.2.32;3.6.-.-;2.7.11.22;2.7.11.23;2.7.11.24;3.1.-.-;3.4.19.12;4.2.99.18;3.2.2.-;3.6.4.13;4.2.99.-;5.2.1.8", "go_molecular_function": "GO:0003909 DNA ligase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0070421 DNA ligase III-XRCC1 complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UIR3-1", "uniprot_id": "DTX3L_MOUSE", "mass": 83044.0, "length": 748, "protein_name": "E3 ubiquitin-protein ligase DTX3L", "gene_name": "Dtx3l", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase DTX3L", "refseq_ac": "NP_001013389", "gene_names_uniprotkb": "Dtx3l; Bbap", "gene_names_refseq": "Dtx3l", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DTX3L; 2.3.2.27; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX3L; RING-type E3 ubiquitin transferase DTX3L", "tax_id": 10090, "disease": "", "pathway": " (mmu:209200); (R-MMU-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18069692;22645316;25605945;26479788;34428180", "class_list": "", "function": "Data indicate that PARP polymerase PARP9-E3 ligase DTX3L interacts with STAT1 transcription factor and enhances translocation of STAT1 to the nucleus., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN11", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:2000646 positive regulation of receptor catabolic process;GO:0007219 Notch signaling pathway;GO:0015031 protein transport;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UIR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3USZ8-1", "uniprot_id": "DIK2A_MOUSE", "mass": 49463.0, "length": 430, "protein_name": "Divergent protein kinase domain 2A", "gene_name": "Dipk2a", "organism": "Mouse", "refseq_name": "divergent protein kinase domain 2A precursor", "refseq_ac": "NP_001028317", "gene_names_uniprotkb": "Dipk2a", "gene_names_refseq": "1190002N15Rik; Dipk2a; GoPro49; HASF", "protein_names_uniprotkb": "Divergent protein kinase domain 2A; Deleted in autism protein 1 homolog; GoPro49; Golgi Protein of 49 kDa; HASF; Hypoxia and AKT-induced stem cell factor", "protein_names_refseq": "Golgi Protein of 49 kDa; Golgi protein GoPro49; UPF0672 protein C3orf58 homolog; deleted in autism protein 1 homolog; divergent protein kinase domain 2A precursor; hypoxia and AKT-induced stem cell factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68861)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18651652;19587158;23784961;24269490;28096202;34203471", "class_list": "", "function": "A novel, specific marker for the dental follicle, [RefSeq, PubMed]; GoPro49 is a new gene expressed specifically in mesenchymal and cartilaginous tissues during development, [RefSeq, PubMed]; HASF (GoPro49) is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection., [RefSeq, PubMed]; HASF is a novel ligand of IGF1R. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q9E9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030137 COPI-coated vesicle;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0034392 negative regulation of smooth muscle cell apoptotic process;GO:0060038 cardiac muscle cell proliferation;GO:0048199 vesicle targeting, to, from or within Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3USZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61880-1", "uniprot_id": "DMC1_MOUSE", "mass": 37821.0, "length": 340, "protein_name": "Meiotic recombination protein DMC1 homolog", "gene_name": "Dmc1", "organism": "Mouse", "refseq_name": "meiotic recombination protein DMC1/LIM15 homolog isoform 1", "refseq_ac": "NP_034189", "gene_names_uniprotkb": "Dmc1; Dmc1h; Lim15", "gene_names_refseq": "Dmc1h; Dmc1; Lim15; Mei11; sgdp", "protein_names_uniprotkb": "Meiotic recombination protein DMC1 homolog; 3.6.4.-", "protein_names_refseq": "DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination; disrupted meiotic cDNA 1 homolog; meiotic recombination protein DMC1/LIM15 homolog isoform 1; meiotic recombination protein DMC1/LIM15 homolog", "tax_id": 10090, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457)", "pathway": " (mmu:13404); (R-MMU-912446)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15834424;17639081;21307306;21750661;22549958;30084848;30746471;30760716;30949703;32463460;32610038;37891173;8581742;8602360;9660953;9660954", "class_list": "", "function": "Homologous DNA recombinase that catalyzes strand exchange during meiotic recombination (PubMed:17639081, PubMed:32610038, PubMed:37891173, PubMed:9660953, PubMed:9660954). Specifically required for meiotic recombination, facilitating the search and repair of DNA using the homolog rather than the sister chromatid, and can tolerate mismatches in heteroduplex DNA, unlike the higher-fidelity RAD51 (PubMed:17639081, PubMed:32610038)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;5.6.2.1;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;2.7.11.22;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;2.7.11.1;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:0006312 mitotic recombination;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0001541 ovarian follicle development;GO:0001556 oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NT99-1", "uniprot_id": "DUS23_MOUSE", "mass": 16637.0, "length": 150, "protein_name": "Dual specificity protein phosphatase 23", "gene_name": "Dusp23", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 23", "refseq_ac": "NP_081001", "gene_names_uniprotkb": "Dusp23; Ldp3", "gene_names_refseq": "1300005N15Rik; Dusp23; LDP-3", "protein_names_uniprotkb": "Dual specificity protein phosphatase 23; 3.1.3.16; 3.1.3.48; LDP-3; Low molecular mass dual specificity phosphatase 3", "protein_names_refseq": "dual specificity protein phosphatase 23; low molecular mass dual specificity phosphatase 3; low-molecular-mass dual-specificity phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68440)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15281913;27255161", "class_list": "", "function": "Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14)., [UniProtKB, PubMed]; Results show that DUSP23 controls the association between alpha- and beta-catenin by promoting dephosphorylation of Tyr142 and identify a previously unrecognized role for DUSP23 in regulating E-cadherin adherens junctions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW48", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NT99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P253-1", "uniprot_id": "DMKN_MOUSE", "mass": 51661.0, "length": 517, "protein_name": "Dermokine", "gene_name": "Dmkn", "organism": "Mouse", "refseq_name": "dermokine isoform d precursor", "refseq_ac": "NP_001159646", "gene_names_uniprotkb": "Dmkn", "gene_names_refseq": "1110014F24Rik; C130074A08; Dmkn; SK30; SK89; cI-36", "protein_names_uniprotkb": "Dermokine; Epidermis-specific secreted protein SK30/SK89", "protein_names_refseq": "dermokine isoform d precursor; epidermis-specific secreted protein SK30/SK89", "tax_id": 10090, "disease": "", "pathway": " (mmu:73712)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15234001;15256262;17330888;17380110;21750661;23428944;24794495;28011936;34428180;35981655", "class_list": "", "function": "Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification., [RefSeq, PubMed]; Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex., [RefSeq, PubMed]; Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice., [RefSeq, PubMed]; Identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis, [RefSeq, PubMed]; May act as a soluble regulator of keratinocyte differentiation., [UniProtKB]; Overexpression of Dermokine-alpha enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells., [RefSeq, PubMed]; These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6E0U6;Q6SZJ9;Q9D1D0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030154 cell differentiation;GO:0061436 establishment of skin barrier;GO:0043588 skin development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P253-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6V3W6-1", "uniprot_id": "DRC7_MOUSE", "mass": 103269.0, "length": 876, "protein_name": "Dynein regulatory complex subunit 7", "gene_name": "Drc7", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 7", "refseq_ac": "NP_001036180", "gene_names_uniprotkb": "Drc7; Ccdc135; Gm770; Srgl", "gene_names_refseq": "Ccdc135; Drc7; Gm770; SRG-L; SRG-S", "protein_names_uniprotkb": "Dynein regulatory complex subunit 7; Coiled-coil domain-containing protein 135; Coiled-coil domain-containing protein lobo homolog; Spermatogenesis-related gene in late stages of spermatogenesis cells protein", "protein_names_refseq": "coiled-coil domain containing 135; coiled-coil domain-containing protein 135; coiled-coil domain-containing protein lobo homolog; dynein regulatory complex subunit 7; spermatogenesis-related gene in late stages of spermatogenesis cells protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:330830)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15156272;16804880;17971504;25428506;28630322;31961863;35820727", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (PubMed:31961863). Not required for ciliogenesis in the brain and trachea (PubMed:31961863)., [UniProtKB, UniProtKB, PubMed]; Drc7 KO male mice were infertile due to their short immotile spermatozoa. Drc7 is essential for the correct assembly of the N-DRC and flagella. Publication Status: Online-Only, [RefSeq, PubMed]; Gm770 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; SRG-L (Spermatogenesis Related Gene expressed in late stages of spermatogenic cells) may play definite roles regulating differentiation of germ cells during spermatogenesis, particularly during meiosis and spermiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9B0;Q148T2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6V3W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQJ5-1", "uniprot_id": "DNA2_MOUSE", "mass": 119447.0, "length": 1062, "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "Dna2", "organism": "Mouse", "refseq_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "refseq_ac": "NP_796346", "gene_names_uniprotkb": "Dna2; Dna2l; Kiaa0083", "gene_names_refseq": "Dna2l; Dna2; E130315B21Rik", "protein_names_uniprotkb": "DNA replication ATP-dependent helicase/nuclease DNA2; DNA 5'-3' helicase DNA2; DNA replication ATP-dependent helicase-like homolog", "protein_names_refseq": "DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2-like helicase", "tax_id": 10090, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); Seckel syndrome 8 (Disease Ontology:DOID:0070009); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (Disease Ontology:DOID:0111519); cancer (Disease Ontology:DOID:162); Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:327762); (R-MMU-174437); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69166); (R-MMU-69473)", "pathway_count": 12, "publication_count": 5, "publication_id_list": "21572043;23604072;26491943;29187734;34428180", "class_list": "", "function": "Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2., [RefSeq, PubMed]; DNA2 helicase cleaves G-quadruplex DNA and is required for telomere integrity.DNA2 reduces replication stress at telomeres, thereby preserving genome stability and suppressing cancer development., [RefSeq, PubMed]; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is absent to weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity)., [UniProtKB, UniProtKB]; The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BM9;Q8BSZ0;Q8R3J3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6ZQJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78YY6-1", "uniprot_id": "DJC15_MOUSE", "mass": 15953.0, "length": 149, "protein_name": "DnaJ homolog subfamily C member 15", "gene_name": "Dnajc15", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily C member 15", "refseq_ac": "NP_079660", "gene_names_uniprotkb": "Dnajc15; Dnajd1", "gene_names_refseq": "1110003P16Rik; Dnajc15; Dnajd1; MCJ", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 15", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 15; DnaJ (Hsp40) homolog, subfamily D, member 1; dnaJ homolog subfamily C member 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:66148)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23530063", "class_list": "", "function": "Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By similarity). Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP., [UniProtKB, PubMed]; DNAJC15 localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer chain.DnaJC15 functions as a negative regulator of mitochondrial membrane potential and ATP production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0019216 regulation of lipid metabolic process;GO:0031333 negative regulation of protein-containing complex assembly;GO:0009267 cellular response to starvation;GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78YY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMD7-1", "uniprot_id": "DSG4_MOUSE", "mass": 114449.0, "length": 1041, "protein_name": "Desmoglein-4", "gene_name": "Dsg4", "organism": "Mouse", "refseq_name": "desmoglein-4 preproprotein", "refseq_ac": "NP_853543", "gene_names_uniprotkb": "Dsg4", "gene_names_refseq": "CDHF13; Dsg4; lah", "protein_names_uniprotkb": "Desmoglein-4", "protein_names_refseq": "desmoglein-4 preproprotein", "tax_id": 10090, "disease": "hypotrichosis 6 (Disease Ontology:DOID:0110703); hypotrichosis (Disease Ontology:DOID:4535); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:16769); (R-MMU-6805567); (R-MMU-6809371)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12705872;12787123;16382669;18677469;18692037;19683850;25428506", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:12705872). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (PubMed:12705872). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity)., [UniProtKB, PubMed, UniProtKB]; Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development., [RefSeq, PubMed]; Mast cell hyperplasia is associated with Dsg4-deficient hypotrichosis mice., [RefSeq, PubMed]; Show that HOXC13, LEF1 and FOXN1 repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch pathway with the activation and/or maintenance of DSG4 expression in the hair follicle., [RefSeq, PubMed]; Smad4 loss-associated Dsg4 depletion contributed, at least in part, to hair follicles degeneration in Smad4 deficient skin., [RefSeq, PubMed]; The abnormal hair follicles in the mutant mice develop an amorphous keratinized bleb at the bulb of the hair follicle., [RefSeq, PubMed]; This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. This gene is expressed in the suprabasal epidermis and hair follicle. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the lanceolate hair phenotype in mice. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0030509 BMP signaling pathway;GO:0001942 hair follicle development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TMD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG36-1", "uniprot_id": "DMRT2_MOUSE", "mass": 61641.0, "length": 561, "protein_name": "Doublesex- and mab-3-related transcription factor 2", "gene_name": "Dmrt2", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor 2", "refseq_ac": "NP_665830", "gene_names_uniprotkb": "Dmrt2", "gene_names_refseq": "Dmrt2; Terra", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 2; Doublesex-like 2 protein; Terra", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 2; doublesex-like 2 protein; terra homolog", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:226049)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10021344;10857744;12609607;16387292;17605809;17974128;20368965;21203428;37713629", "class_list": "", "function": "Dmrt2 is involved in somite development and provide evidence that DM domain genes have been co-opted into other critical developmental pathways distinct from that of sex determination or differentiation., [RefSeq, PubMed]; TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans., [RefSeq, PubMed]; Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USI4;Q3USI7;Q8K185;Q9JJU0;Q9JJU3;Q9WVM0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2000287 positive regulation of myotome development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BG36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGS1-1", "uniprot_id": "E41L5_MOUSE", "mass": 81636.0, "length": 731, "protein_name": "Band 4.1-like protein 5", "gene_name": "Epb41l5", "organism": "Mouse", "refseq_name": "band 4.1-like protein 5 isoform 2", "refseq_ac": "NP_001106887", "gene_names_uniprotkb": "Epb41l5; Epb4.1l5; Kiaa1548", "gene_names_refseq": "1700030C16Rik; BE37; E230025E14Rik; Epb4.1l5; Epb41l5; Lulu1; NBL5", "protein_names_uniprotkb": "Band 4.1-like protein 5; Erythrocyte membrane protein band 4.1-like 5", "protein_names_refseq": "band 4.1-like protein 5 isoform 2; band 4.1-like protein 5; erythrocyte protein band 4.1-like 5", "tax_id": 10090, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:226352); (R-MMU-6794361)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17507402;17920587;21750661;24129315;25428506;30084848;30779550;33761352;34203471;34428180;40997131", "class_list": "", "function": "EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission., [RefSeq, PubMed]; Lulu mutation in Epb4.1l5 helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis., [RefSeq, PubMed]; Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJG0;Q69ZG8;Q8BSC9;Q99KZ8", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0010608 post-transcriptional regulation of gene expression;GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0022408 negative regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BGS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPA8-1", "uniprot_id": "DPCD_MOUSE", "mass": 23034.0, "length": 203, "protein_name": "Protein DPCD", "gene_name": "Dpcd", "organism": "Mouse", "refseq_name": "protein DPCD isoform 1", "refseq_ac": "NP_766227", "gene_names_uniprotkb": "Dpcd", "gene_names_refseq": "Dpcd; Gm17018; Ndac", "protein_names_uniprotkb": "Protein DPCD", "protein_names_refseq": "neighbor of Dac; protein DPCD isoform 1; protein DPCD", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:226162)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20080492;21750661", "class_list": "", "function": "May play a role in the formation or function of ciliated cells., [UniProtKB]; Situs inversus in Dpcd/Poll-/- knockout mice, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1L8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BPA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0M8-1", "uniprot_id": "DNAI1_MOUSE", "mass": 79758.0, "length": 701, "protein_name": "Dynein axonemal intermediate chain 1", "gene_name": "Dnai1", "organism": "Mouse", "refseq_name": "dynein axonemal intermediate chain 1", "refseq_ac": "NP_780347", "gene_names_uniprotkb": "Dnai1; Dnaic1", "gene_names_refseq": "1110066F04Rik; Dnai1; Dnaic1; b2b1526Clo", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 1; Axonemal dynein intermediate chain 1", "protein_names_refseq": "axonemal dynein intermediate chain 1; dynein axonemal intermediate chain 1; dynein intermediate chain 1, axonemal", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 1 (Disease Ontology:DOID:0110594)", "pathway": " (mmu:68922)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19675306;26501274;30059200;33347437;37352829;37458246", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]; Dnaic1 deletion in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKY5", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0030317 flagellated sperm motility;GO:0008286 insulin receptor signaling pathway;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C0M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE22-1", "uniprot_id": "DMTF1_MOUSE", "mass": 84644.0, "length": 761, "protein_name": "Cyclin-D-binding Myb-like transcription factor 1", "gene_name": "Dmtf1", "organism": "Mouse", "refseq_name": "cyclin-D-binding Myb-like transcription factor 1 isoform 2", "refseq_ac": "NP_001103797", "gene_names_uniprotkb": "Dmtf1; Dmp1", "gene_names_refseq": "Dimp; Dmp1; Dmtf1", "protein_names_uniprotkb": "Cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; mDmp1", "protein_names_refseq": "D-interacting myb-like protein; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin-D-binding Myb-like transcription factor 1 isoform 2; cyclin-D-binding Myb-like transcription factor 1; cyclin-D-interacting Myb-like protein 1; mDmp1", "tax_id": 10090, "disease": "", "pathway": " (mmu:23857)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10097151;10898794;11711428;15601844;16878159;17546045;17936562;21750661;23938323;28406729;8887674;9488476;9786929", "class_list": "", "function": "Dmp1 (Dmp1alpha) physically interacts with p53, stabilizes p53's binding to its target genes, and increases the transcriptional activity of p53., [RefSeq, PubMed]; This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer., [RefSeq, PubMed]; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70413;Q3TUR9;Q80VR8;Q8BQX6;Q8CA56;Q8CCZ0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8CE22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFG4-1", "uniprot_id": "DMRTA_MOUSE", "mass": 52653.0, "length": 490, "protein_name": "Doublesex- and mab-3-related transcription factor A1", "gene_name": "Dmrta1", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor A1", "refseq_ac": "NP_783578", "gene_names_uniprotkb": "Dmrta1; Dmrt4", "gene_names_refseq": "Dmrt4; Dmrta1", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A1; Doublesex- and mab-3-related transcription factor 4", "protein_names_refseq": "doublesex and mab-3 related transcription factor 4; doublesex- and mab-3-related transcription factor A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242523)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12609607;16982677", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AL09", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060179 male mating behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001541 ovarian follicle development;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGW9-1", "uniprot_id": "DMRTD_MOUSE", "mass": 39095.0, "length": 370, "protein_name": "Doublesex- and mab-3-related transcription factor C2", "gene_name": "Dmrtc2", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor C2", "refseq_ac": "NP_082008", "gene_names_uniprotkb": "Dmrtc2; Dmrt7", "gene_names_refseq": "4933432E21Rik; Dmrt7; Dmrtc2", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor C2; Doublesex- and mab-3-related transcription factor 7", "protein_names_refseq": "doublesex and mab-3 related transcription factor 7; doublesex- and mab-3-related transcription factor C2", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:71241)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12609607;17098235;17447844", "class_list": "", "function": "DMRT7 may help control the transition from meiotic sex chromosome inactivation to postmeiotic sex chromatin in males., [RefSeq, PubMed]; Decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice., [RefSeq, PubMed]; May be involved in sexual development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6T0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001741 XY body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007548 sex differentiation;GO:0007141 male meiosis I;GO:0070828 heterochromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CGW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0W9-1", "uniprot_id": "DPH3_MOUSE", "mass": 9286.0, "length": 82, "protein_name": "Diphthamide biosynthesis protein 3", "gene_name": "Dph3", "organism": "Mouse", "refseq_name": "diphthamide biosynthesis protein 3 isoform 2", "refseq_ac": "NP_001040898", "gene_names_uniprotkb": "Dph3; Desr1; Zcsl2", "gene_names_refseq": "DELGIP1; DelgipP1; Desr1; Dph3; KTI11; Zcsl2", "protein_names_uniprotkb": "Diphthamide biosynthesis protein 3; CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1", "protein_names_refseq": "CSL-type zinc finger-containing protein 2; DPH3 homolog (KTI11, S. cerevisiae); delGEF-interacting protein 1; diphthamide biosynthesis protein 3 isoform 2; diphthamide biosynthesis protein 3; zinc finger, CSL domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:105638); (R-MMU-5358493)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14527407;16648478;21750661;23185508", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine)., [UniProtKB, UniProtKB]; We found that Dph3 promotes melanoma migration and invasion through the AKT signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0009055 electron transfer activity;GO:0008198 ferrous iron binding;GO:0034986 iron chaperone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0017183 protein histidyl modification to diphthamide;GO:0051099 positive regulation of binding;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1E3-1", "uniprot_id": "DLK2_MOUSE", "mass": 40404.0, "length": 382, "protein_name": "Protein delta homolog 2", "gene_name": "Dlk2", "organism": "Mouse", "refseq_name": "protein delta homolog 2 precursor", "refseq_ac": "NP_001272942", "gene_names_uniprotkb": "Dlk2; Egfl9", "gene_names_refseq": "DLK-2; Dlk2; Egfl9", "protein_names_uniprotkb": "Protein delta homolog 2; DLK-2; EGF-like protein 9; Endothelial cell-specific protein S-1; Epidermal growth factor-like protein 9", "protein_names_refseq": "EGF-like protein 9; EGF-like-domain, multiple 9; delta-like 2 homolog; endothelial cell-specific protein S-1; epidermal growth factor-like protein 9; protein delta homolog 2 precursor; protein delta homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:106565)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17320102;21419176;21750661;22185379;22306741;25428506;29057471;30888503;37669921", "class_list": "", "function": "Adipogenesis may be modulated by the coordinated expression of Dlk1 and EGFL9/Dlk2., [RefSeq, PubMed]; Data show that DLK1 and DLK2 act as inhibitory non-canonical protein ligands for the NOTCH1 receptor that modulate NOTCH signaling., [RefSeq, PubMed]; Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation. Publication Status: Online-Only, [RefSeq, PubMed]; KLF4 mediates the transcriptional regulation of Dlk2 in response to IBMX during the early stages of adipogenesis, [RefSeq, PubMed]; Our results provide the first characterization of Dlk2 transcripts, map the location of the Dlk2 core promoter, and show the role of Sp1 as a key regulator of Dlk2 transcription Publication Status: Online-Only, [RefSeq, PubMed]; Regulates adipogenesis., [UniProtKB, PubMed]; The expression of the Dlk2 protein in the limb bud could be detected at embryonic day 11.5., [RefSeq, PubMed]; The expression pattern of DLK2 indicates that both proteins could play a synergistic role during cell differentiation. Erratum:[Histochem Cell Biol. 2019 Jul;152(1):61-62. doi: 10.1007/s00418-019-01790-8. PMID: 31093774], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5B9L4;Q0IIP7;Q148N7;Q9QYP3", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045746 negative regulation of Notch signaling pathway;GO:0045598 regulation of fat cell differentiation;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K1E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4T5-1", "uniprot_id": "DUS19_MOUSE", "mass": 24181.0, "length": 220, "protein_name": "Dual specificity protein phosphatase 19", "gene_name": "Dusp19", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Dusp19; Skrp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity protein phosphatase 19; 3.1.3.16; 3.1.3.48; Protein phosphatase SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11959861", "class_list": "", "function": "Has a dual specificity toward Ser/Thr and Tyr-containing proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0008579 JUN kinase phosphatase activity;GO:0030295 protein kinase activator activity;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0007254 JNK cascade;GO:0006470 protein dephosphorylation;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R242-1", "uniprot_id": "DIAC_MOUSE", "mass": 41295.0, "length": 366, "protein_name": "Di-N-acetylchitobiase", "gene_name": "Ctbs", "organism": "Mouse", "refseq_name": "di-N-acetylchitobiase isoform 1 precursor", "refseq_ac": "NP_001280601", "gene_names_uniprotkb": "Ctbs", "gene_names_refseq": "2210401K11Rik; CTB; Ctbs", "protein_names_uniprotkb": "Di-N-acetylchitobiase; 3.2.1.-", "protein_names_refseq": "chitobiase, di-N-acetyl-; di-N-acetylchitobiase isoform 1 precursor; di-N-acetylchitobiase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74245)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;18440730;21750661;22465033;26192747;30779550;32799730;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals., [RefSeq, PubMed]; Reducing-end exoglycosidase involved in glycan degradation (PubMed:18440730, PubMed:22465033, PubMed:32799730). Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (PubMed:18440730, PubMed:32799730). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q102J0;Q9D7V4", "ec_number_list": "3.2.1.-", "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0004568 chitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0006032 chitin catabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCR2-1", "uniprot_id": "DHB13_MOUSE", "mass": 33458.0, "length": 304, "protein_name": "17-beta-hydroxysteroid dehydrogenase 13", "gene_name": "Hsd17b13", "organism": "Mouse", "refseq_name": "17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor", "refseq_ac": "NP_001156958", "gene_names_uniprotkb": "Hsd17b13; Scdr9", "gene_names_refseq": "Hsd17b13; PAN1B-like; Pan1b", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase 13; 1.1.1.-; 1.1.1.105; 1.1.1.62; 17-beta-HSD 13; Alcohol dehydrogenase PAN1B-like; Hepatic retinol/retinal dehydrogenase; Short-chain dehydrogenase/reductase 9", "protein_names_refseq": "17-beta-HSD 13; 17-beta-hydroxysteroid dehydrogenase 13 isoform 1 precursor; 17-beta-hydroxysteroid dehydrogenase 13; hepatic retinol/retinal dehydrogenase; short-chain dehydrogenase/reductase 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:243168); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17242355;18359291;21750661;23576753;29401633;30084848;34428180;36323699;37453647;38779753", "class_list": "", "function": "17betaHSD type 13 may have a distinct physiological role as a lipid droplet-associated protein in the liver., [RefSeq, PubMed]; Data indicate that disruption of Hsd17b13 impairs hepatic-lipid metabolism in mice, resulting in liver steatosis and inflammation, but the enzyme does not play a major role in the regulation of reproductive functions., [RefSeq, PubMed]; Expression and localization of HSD17B13 along mouse urinary tract., [RefSeq, PubMed]; Phosphorylation of 17beta-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8Y5N6;Q8CIU2", "ec_number_list": "1.1.1.300;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.1.1.330;1.2.1.36;1.2.1.19;1.2.1.3;1.2.1.28;1.1.1.n12;1.1.1.51;1.1.1.105;1.1.1.209;1.1.1.1;1.1.1.66;1.1.1.-;1.7.1.-", "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0046889 positive regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VCR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEJ3-1", "uniprot_id": "DKK4_MOUSE", "mass": 24261.0, "length": 221, "protein_name": "Dickkopf-related protein 4", "gene_name": "Dkk4", "organism": "Mouse", "refseq_name": "dickkopf-related protein 4 precursor", "refseq_ac": "NP_663567", "gene_names_uniprotkb": "Dkk4", "gene_names_refseq": "Dkk-4; Dkk4", "protein_names_uniprotkb": "Dickkopf-related protein 4; Dickkopf-4; Dkk-4", "protein_names_refseq": "dickkopf homolog 4; dickkopf-4; dickkopf-related protein 4 precursor; dickkopf-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:234130); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17143291;17397822;25428506", "class_list": "", "function": "Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)., [UniProtKB]; Dkk4 acts in a negative feedback loop to attenuate canonical Wnt signaling and may facilitate a switch to the non-canonical Wnt planar cell polarity pathway that is involved in cell movements during morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0061170 negative regulation of hair follicle placode formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VEJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZM9-1", "uniprot_id": "DOK5_MOUSE", "mass": 35453.0, "length": 306, "protein_name": "Docking protein 5", "gene_name": "Dok5", "organism": "Mouse", "refseq_name": "docking protein 5 isoform 2", "refseq_ac": "NP_001157158", "gene_names_uniprotkb": "Dok5", "gene_names_refseq": "2700055C10Rik; Dok5", "protein_names_uniprotkb": "Docking protein 5; Downstream of tyrosine kinase 5", "protein_names_refseq": "docking protein 5 isoform 2; downstream of tyrosine kinase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76829); (R-MMU-8853659)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11470823;19800350;23954828;24551065;30515784;35234166", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation., [UniProtKB, PubMed]; Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis, [RefSeq, PubMed]; Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/beta-catenin signaling., [RefSeq, PubMed]; FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5., [RefSeq, PubMed]; IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; The study suggests that miR-141-3p inhibits retinal neovascularization in glaucoma mice by impeding the activation of the DOK5-mediated MAPK signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRI3;Q9CSM6", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0030182 neuron differentiation;GO:0051386 regulation of neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91ZM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J47-1", "uniprot_id": "PEXRP_MOUSE", "mass": 34987.0, "length": 323, "protein_name": "Peroxisomal reductase activating PPAR-gamma", "gene_name": "Dhrs7b", "organism": "Mouse", "refseq_name": "peroxisomal reductase activating PPAR-gamma isoform 1", "refseq_ac": "NP_001165583", "gene_names_uniprotkb": "Dhrs7b; Sdr32c1", "gene_names_refseq": "Dhrs7b; PexRAP", "protein_names_uniprotkb": "Peroxisomal reductase activating PPAR-gamma; 1.1.1.101; Dehydrogenase/reductase SDR family member 7B; PexRAP; Protein SDR32C1; Short-chain dehydrogenase/reductase family 32C member 1", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 7B; peroxisomal reductase activating PPAR-gamma isoform 1; peroxisomal reductase activating PPAR-gamma; short-chain dehydrogenase/reductase family 32C member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:216820); (R-MMU-75896)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;22863804;28930673;31219806;34428180", "class_list": "", "function": "PexRAP also interacts with PPARgamma, as well as PRDM16, a critical transcriptional regulator of thermogenesis, and disrupts the PRDM16-PPARgamma complex, providing a potential mechanism for PexRAP-mediated inhibition of adipocyte browning., [RefSeq, PubMed]; PexRAP knockdown in mice decreased expression of PPARgamma-dependent genes and reduced diet-induced adiposity., [RefSeq, PubMed]; Reductase required for adipogenesis and activation of PPARG nuclear receptor (PubMed:22863804, PubMed:28930673). Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG (PubMed:22863804). Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes (PubMed:28930673)., [UniProtKB, PubMed, PubMed]; Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNS3;Q5NCT5", "ec_number_list": "1.1.1.101", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000140 acylglycerone-phosphate reductase (NADP+) activity;GO:0140297 DNA-binding transcription factor binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0008611 ether lipid biosynthetic process;GO:0050873 brown fat cell differentiation;GO:0060612 adipose tissue development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99J47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KK7-1", "uniprot_id": "DPP3_MOUSE", "mass": 82898.0, "length": 738, "protein_name": "Dipeptidyl peptidase 3", "gene_name": "Dpp3", "organism": "Mouse", "refseq_name": "dipeptidyl peptidase 3", "refseq_ac": "NP_598564", "gene_names_uniprotkb": "Dpp3", "gene_names_refseq": "4930533O14Rik; DPP III; Dpp3", "protein_names_uniprotkb": "Dipeptidyl peptidase 3; 3.4.14.4; DPP III; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; Enkephalinase B", "protein_names_refseq": "dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase 3; dipeptidyl peptidase III; dipeptidyl-peptidase 3; dipeptidylpeptidase III; enkephalinase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:75221)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;24216478;31295380;32546481;33812256;34428180;36382663;37453647;37507081;37828378;39627609;40885482", "class_list": "", "function": "Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss., [RefSeq, PubMed]; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro)., [UniProtKB, UniProtKB]; DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma., [RefSeq, PubMed]; Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice., [RefSeq, PubMed]; Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling., [RefSeq, PubMed]; The cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0I6", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99KK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KV1-1", "uniprot_id": "DJB11_MOUSE", "mass": 40555.0, "length": 358, "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "Dnajb11", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 11 precursor", "refseq_ac": "NP_001177733", "gene_names_uniprotkb": "Dnajb11", "gene_names_refseq": "1810031F23Rik; ABBP-2; Dj9; Dnajb11; ERdj3; ERj3p", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 11; ABBP-2; APOBEC1-binding protein 2; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; ER-resident protein ERdj3; ERdj3; ERj3p; Endoplasmic reticulum DNA J domain-containing protein 3", "protein_names_refseq": "APOBEC1-binding protein 2; DnaJ (Hsp40) homolog, subfamily B, member 11; ER-associated Hsp40 co-chaperone; ER-associated dnaJ protein 3; ER-resident protein ERdj3; dnaJ homolog subfamily B member 11 precursor; dnaJ homolog subfamily B member 11; endoplasmic reticulum DNA J domain-containing protein 3", "tax_id": 10090, "disease": "polycystic kidney disease 6 (Disease Ontology:DOID:0060951)", "pathway": " (mmu:67838)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11584023;12475965;15525676;19224205;20173027;21750661;22872234;25428506;26740625;30084848;30779550;32152506;34428180;35820727", "class_list": "", "function": "As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6X957;Q543I7;Q8BK79;Q8VCY1;Q8VHB1", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051082 unfolded protein binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016556 mRNA modification;GO:0006457 protein folding;GO:0032781 positive regulation of ATP-dependent activity;GO:0050768 negative regulation of neurogenesis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99KV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MU3-1", "uniprot_id": "DSRAD_MOUSE", "mass": 130447.0, "length": 1178, "protein_name": "Double-stranded RNA-specific adenosine deaminase", "gene_name": "Adar", "organism": "Mouse", "refseq_name": "double-stranded RNA-specific adenosine deaminase isoform 3", "refseq_ac": "NP_001139768", "gene_names_uniprotkb": "Adar", "gene_names_refseq": "Adar1p110; Adar1p150; Adar1; Adar; DRADA; mZaADAR", "protein_names_uniprotkb": "Double-stranded RNA-specific adenosine deaminase; 3.5.4.37; DRADA; RNA adenosine deaminase 1", "protein_names_refseq": "RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form; double-stranded RNA-specific adenosine deaminase isoform 3; double-stranded RNA-specific adenosine deaminase", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); dyschromatosis symmetrica hereditaria (Disease Ontology:DOID:0060257); stomach cancer (Disease Ontology:DOID:10534); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:56417); (R-MMU-75102); (R-MMU-77042); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12618436;12709013;12954622;14613934;14615479;15556947;16055709;17079286;17369310;21182352;21183079;22645316;24129315;28960389;31219806;34428180;36210013", "class_list": "", "function": "ADAR1 functions other than RNA editing are reviewed. Review article, [RefSeq, PubMed]; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70375;Q80UZ6;Q8C222;Q99MU2;Q99MU4;Q99MU7", "ec_number_list": "2.7.10.2;2.7.11.1;3.5.4.37", "go_molecular_function": "GO:0003692 left-handed Z-DNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99MU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ00-1", "uniprot_id": "DMAC1_MOUSE", "mass": 11344.0, "length": 111, "protein_name": "Distal membrane-arm assembly complex protein 1", "gene_name": "Dmac1", "organism": "Mouse", "refseq_name": "distal membrane-arm assembly complex protein 1", "refseq_ac": "NP_080125", "gene_names_uniprotkb": "Dmac1; Tmem261", "gene_names_refseq": "1700027K24Rik; 3110001D03Rik; Dmac1; Tmem261", "protein_names_uniprotkb": "Distal membrane-arm assembly complex protein 1; Transmembrane protein 261", "protein_names_refseq": "distal membrane-arm assembly complex protein 1; transmembrane protein 261; transmembrane protein C9orf123 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66928); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQ00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQS7-1", "uniprot_id": "DPA5A_MOUSE", "mass": 13810.0, "length": 118, "protein_name": "Developmental pluripotency-associated protein 5A", "gene_name": "Dppa5a", "organism": "Mouse", "refseq_name": "developmental pluripotency-associated protein 5A", "refseq_ac": "NP_079550", "gene_names_uniprotkb": "Dppa5a; Dppa5; Ecat2; Esg1; Ph34", "gene_names_refseq": "Dppa5a; Dppa5; Esg1; ecat2", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 5A; ES cell-associated transcript 2 protein; ESG-1; Embryonal stem cell-specific gene 1 protein; Protein pH 34; mDppa5", "protein_names_refseq": "ES cell-associated transcript 2 protein; ESG-1; developmental pluripotency associated 5; developmental pluripotency-associated protein 5A; embryonal stem cell specific gene 1; embryonal stem cell-specific gene 1 protein; mDppa5; protein pH 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:434423)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12466296;12620990;15790765;16166252;16504174;16872451;17913455;2044862;38227647;8123591", "class_list": "", "function": "Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of germ cells. Associates with specific target mRNAs., [UniProtKB, PubMed]; Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CQS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NCS9-1", "uniprot_id": "MID49_MOUSE", "mass": 49624.0, "length": 454, "protein_name": "Mitochondrial dynamics protein MID49", "gene_name": "Mief2", "organism": "Mouse", "refseq_name": "mitochondrial dynamics protein MID49", "refseq_ac": "NP_001009927", "gene_names_uniprotkb": "Mief2; Gm11; Mid49; Smcr7", "gene_names_refseq": "Gm11; Mief2; Smcr7", "protein_names_uniprotkb": "Mitochondrial dynamics protein MID49; Mitochondrial dynamics protein of 49 kDa homolog; Mitochondrial elongation factor 2; Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog", "protein_names_refseq": "mitochondrial dynamic protein MID49; mitochondrial dynamic protein of 49 kDa homolog; mitochondrial dynamics protein MID49; mitochondrial dynamics protein of 49 kDa homolog; smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 49 (Disease Ontology:DOID:0112110)", "pathway": " (mmu:237781)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23283981;23921378;24508339;25581164;26101352;27076521;31219806;34428180;36210013", "class_list": "", "function": "Determined the crystal structure and fperformed unctional analysis of mouse MiD49., [RefSeq, PubMed]; MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria., [RefSeq, PubMed]; MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity., [RefSeq, PubMed]; Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity., [UniProtKB, PubMed, PubMed]; This paper combines confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the endoplasmic reticulum in mitochondrial fission., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0090314 positive regulation of protein targeting to membrane;GO:0010821 regulation of mitochondrion organization;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5NCS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHR0-1", "uniprot_id": "PCD18_MOUSE", "mass": 125420.0, "length": 1134, "protein_name": "Protocadherin 18", "gene_name": "Pcdh18", "organism": "Mouse", "refseq_name": "protocadherin 18 isoform 1 precursor", "refseq_ac": "NP_569715", "gene_names_uniprotkb": "Pcdh18; Kiaa1562", "gene_names_refseq": "3110038E07Rik; PCDH68L; Pcdh18", "protein_names_uniprotkb": "Protocadherin 18", "protein_names_refseq": "protocadherin 18 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73173)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11716507;21750661;34428180", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZG2;Q80VY4;Q8CB88", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0N8-1", "uniprot_id": "TMM88_MOUSE", "mass": 17358.0, "length": 159, "protein_name": "Transmembrane protein 88", "gene_name": "Tmem88", "organism": "Mouse", "refseq_name": "transmembrane protein 88", "refseq_ac": "NP_080191", "gene_names_uniprotkb": "Tmem88", "gene_names_refseq": "2600017H02Rik; Tmem88", "protein_names_uniprotkb": "Transmembrane protein 88", "protein_names_refseq": "transmembrane protein 88", "tax_id": 10090, "disease": "", "pathway": " (mmu:67020)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21044957;32451556", "class_list": "", "function": "Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity)., [UniProtKB]; TMEM88 associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner, [RefSeq, PubMed]; TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497Z2;Q8BRC2", "ec_number_list": "", "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0050821 protein stabilization;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBG9-1", "uniprot_id": "TX1B3_MOUSE", "mass": 13723.0, "length": 124, "protein_name": "Tax1-binding protein 3", "gene_name": "Tax1bp3", "organism": "Mouse", "refseq_name": "tax1-binding protein 3", "refseq_ac": "NP_083840", "gene_names_uniprotkb": "Tax1bp3", "gene_names_refseq": "1300011C24Rik; TIP-1; Tax1bp3", "protein_names_uniprotkb": "Tax1-binding protein 3; TIP-1; Tax interaction protein 1", "protein_names_refseq": "tax interaction protein 1; tax1-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76281)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12874278;18835279;21750661;30016717;32782141;32848054;36892460;37209886", "class_list": "", "function": "Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury., [RefSeq, PubMed]; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity)., [UniProtKB, PubMed]; Tax1 binding protein 3 regulates osteogenic and adipogenic differentiation through inactivating Wnt/beta-catenin signalling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0001650 fibrillar center", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0007266 Rho protein signal transduction;GO:0032489 regulation of Cdc42 protein signal transduction;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DBG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVN3-1", "uniprot_id": "CTSR4_MOUSE", "mass": 51130.0, "length": 442, "protein_name": "Cation channel sperm-associated protein 4", "gene_name": "Catsper4", "organism": "Mouse", "refseq_name": "cation channel sperm-associated protein 4 isoform 2", "refseq_ac": "NP_001123502", "gene_names_uniprotkb": "Catsper4", "gene_names_refseq": "4933412L05; Catsper4", "protein_names_uniprotkb": "Cation channel sperm-associated protein 4; CatSper4", "protein_names_refseq": "cation channel of sperm 4; cation channel sperm-associated protein 4 isoform 2; cation channel sperm-associated protein 4; channel, sperm associated 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:329954); (R-MMU-1300642)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12932298;16107607;17227845;17344468;17347248;18607386;21224844;21412339;21750661;25428506;34225353", "class_list": "", "function": "CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility, [RefSeq, PubMed]; Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions., [RefSeq, PubMed]; Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4., [RefSeq, PubMed]; Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9K6", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0036128 CatSper complex;GO:0001669 acrosomal vesicle;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BVN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925B0-1", "uniprot_id": "PAWR_MOUSE", "mass": 35908.0, "length": 333, "protein_name": "PRKC apoptosis WT1 regulator protein", "gene_name": "Pawr", "organism": "Mouse", "refseq_name": "PRKC apoptosis WT1 regulator protein", "refseq_ac": "NP_473397", "gene_names_uniprotkb": "Pawr; Par4", "gene_names_refseq": "2310001G03Rik; PAR4; Par-4; Pawr", "protein_names_uniprotkb": "PRKC apoptosis WT1 regulator protein; Par-4; Prostate apoptosis response 4 protein", "protein_names_refseq": "PRKC apoptosis WT1 regulator protein; prostate apoptosis response 4 protein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:114774)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15606896;16369487;16520897;20561531;22645316;28528544;29695515;34203471", "class_list": "", "function": "Lack of Par-4 increased the expression of p21 and delayed chronic lymphocytic leukemia (CLL) growth in Emu-Tcl1 mice., [RefSeq, PubMed]; Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0ZHI4;Q2HYJ1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0005080 protein kinase C binding;GO:0043522 leucine zipper domain binding;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0060450 positive regulation of hindgut contraction;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q925B0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61092-1", "uniprot_id": "SIA1A_MOUSE", "mass": 31137.0, "length": 282, "protein_name": "E3 ubiquitin-protein ligase SIAH1A", "gene_name": "Siah1a", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SIAH1A", "refseq_ac": "NP_033198", "gene_names_uniprotkb": "Siah1a", "gene_names_refseq": "Siah1a; Sinh1a", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SIAH1A; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1A; Seven in absentia homolog 1a; Siah-1a; Siah1a; mSiah-1a", "protein_names_refseq": "E3 ubiquitin-protein ligase SIAH1A; RING-type E3 ubiquitin transferase SIAH1A; mSiah-1a; seven in absentia 1A; seven in absentia homolog 1a; siah-1a", "tax_id": 10090, "disease": "", "pathway": " (mmu:20437); (R-MMU-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10681424;11742346;11884614;12417719;12646221;16615911;24809345;25561546;28546513;28843785;34428180;37078793;8404535", "class_list": "", "function": "Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction., [RefSeq, PubMed]; Depletion of KDM3A coincided with the loss of SIAH1 induction and the accumulation of dimethylated H3K9 surrounding the SIAH1 promoter. Interestingly, KDM3A expression was also up-regulated by nutritional stress in a HIF-1alpha dependent manner., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF signaling. Has some overlapping function with SIAH2 (By similarity). Required for completion of meiosis I in males (PubMed:11884614). Induces apoptosis in cooperation with PEG3 (PubMed:10681424). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (PubMed:24809345). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06984", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0040014 regulation of multicellular organism growth;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P61092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70371-1", "uniprot_id": "TERF1_MOUSE", "mass": 48224.0, "length": 421, "protein_name": "Telomeric repeat-binding factor 1", "gene_name": "Terf1", "organism": "Mouse", "refseq_name": "telomeric repeat-binding factor 1 isoform 1", "refseq_ac": "NP_033378", "gene_names_uniprotkb": "Terf1; Trf1", "gene_names_refseq": "Pin2; Terf1; Trbf1; Trf1", "protein_names_uniprotkb": "Telomeric repeat-binding factor 1; TTAGGG repeat-binding factor 1", "protein_names_refseq": "TTAGGG repeat-binding factor 1; telomeric repeat-binding factor 1 isoform 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:21749); (R-MMU-110330); (R-MMU-110331); (R-MMU-171319); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174430); (R-MMU-174437); (R-MMU-2559586); (R-MMU-9670095)", "pathway_count": 11, "publication_count": 11, "publication_id_list": "12944479;14559908;19487455;22872234;22932806;24413433;29040668;31219806;31273934;37598977;9002672", "class_list": "", "function": "Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways., [UniProtKB, PubMed]; Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (day 5 to 6 postcoitus) embryonic lethality.These data suggest that murine Trf1 has an essential function that is independent of telomere length regulation, [RefSeq, PubMed]; Loss of TRF1 leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita., [RefSeq, PubMed]; Mouse HP1gamma regulates TRF1 expression and telomere stability., [RefSeq, PubMed]; TRF1 interacts with other telomere-binding molecules and integrates into the functional telomere structure, [RefSeq, PubMed]; This gene encodes a protein that binds to repeats in telomeres to form a nucleoprotein complex that protects against the degradation of chromosomal ends. The encoded protein regulates the length of telomeres and is an integral structural component of the functional telomere. This protein is thought to play a role in spindle formation in mitosis. Mutations in this gene are associated with bone marrow failure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY71", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0098505 G-rich strand telomeric DNA binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005819 spindle;GO:0001650 fibrillar center", "go_biological_process": "GO:0051301 cell division;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0061820 telomeric D-loop disassembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P70371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02591-1", "uniprot_id": "GSC_MOUSE", "mass": 27980.0, "length": 256, "protein_name": "Homeobox protein goosecoid", "gene_name": "Gsc", "organism": "Mouse", "refseq_name": "homeobox protein goosecoid", "refseq_ac": "NP_034481", "gene_names_uniprotkb": "Gsc", "gene_names_refseq": "Gsc", "protein_names_uniprotkb": "Homeobox protein goosecoid", "protein_names_refseq": "homeobox protein goosecoid", "tax_id": 10090, "disease": "", "pathway": " (mmu:14836)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1352187;14973294;24290375;9417125", "class_list": "glycogene", "function": "Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0030178 negative regulation of Wnt signaling pathway;GO:0042474 middle ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SV77-1", "uniprot_id": "GGNB2_MOUSE", "mass": 78970.0, "length": 696, "protein_name": "Gametogenetin-binding protein 2", "gene_name": "Ggnbp2", "organism": "Mouse", "refseq_name": "gametogenetin-binding protein 2 isoform 3", "refseq_ac": "NP_694784", "gene_names_uniprotkb": "Ggnbp2; Zfp403; Znf403", "gene_names_refseq": "D330017P12Rik; DIF-3; Ggnbp2; Zfp403", "protein_names_uniprotkb": "Gametogenetin-binding protein 2; DIF-3; Dioxin-inducible factor 3; Protein ZNF403", "protein_names_refseq": "dioxin inducible factor 3; gametogenetin-binding protein 2 isoform 3; gametogenin binding protein 2; zinc finger protein 403", "tax_id": 10090, "disease": "", "pathway": " (mmu:217039)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11728448;15642376;21183079;21750661;22645316;30055035;31219806;34428180;36127399;39109527", "class_list": "", "function": "Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation., [RefSeq, PubMed]; GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis., [RefSeq, PubMed]; Ggnbp2 is mainly expressed in the testis. Its protein product interacted with GGN1 and could be involved in intracellular trafficking., [RefSeq, PubMed]; May be involved in spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4QPD5;B7ZP33;Q5SV75;Q5SV76;Q5SV78;Q6GVH6;Q6P9J4;Q920N4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0061099 negative regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SV77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NY15-1", "uniprot_id": "TSG10_MOUSE", "mass": 81262.0, "length": 697, "protein_name": "Testis-specific gene 10 protein", "gene_name": "Tsga10", "organism": "Mouse", "refseq_name": "testis-specific gene 10 protein isoform 2", "refseq_ac": "NP_001277649", "gene_names_uniprotkb": "Tsga10", "gene_names_refseq": "4933432N21Rik; Gm217; Mtsga10; Tsga10", "protein_names_uniprotkb": "Testis-specific gene 10 protein", "protein_names_refseq": "testis-specific gene 10 protein isoform 2; testis-specific gene 10 protein", "tax_id": 10090, "disease": "spermatogenic failure 26 (Disease Ontology:DOID:0111924)", "pathway": " (mmu:211484)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14585816;16643851;16777103;21750661;26791599;32790169;34428180", "class_list": "", "function": "HIF-1alpha nuclear localization and HIF-1 transcriptional activity were significantly affected by overexpressed TSGA10, [RefSeq, PubMed]; Plays a role in spermatogenesis (PubMed:14585816). When overexpressed, prevents nuclear localization of HIF1A (PubMed:16777103)., [UniProtKB, PubMed, PubMed]; This study also shows that Tsga10 expression protects sperm dysfunction in formalin plus manganese-exposed mice resulting in better preservation of spermatozoa and improvement of male fertility., [RefSeq, PubMed]; Tsga10 expression starts in 4.5-7.5 dpc mouse embryos and continues throughout embryogenesis., [RefSeq, PubMed]; Tsga10 is essential for arrangement of mitochondrial sheath and male fertility in mice., [RefSeq, PubMed]; Tsga10 plays a role in the sperm tail fibrous sheath., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68RJ4;Q8K3V2", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0043005 neuron projection;GO:0005814 centriole;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0030031 cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NY15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3X4-1", "uniprot_id": "GUF1_MOUSE", "mass": 72463.0, "length": 651, "protein_name": "Translation factor Guf1, mitochondrial", "gene_name": "Guf1", "organism": "Mouse", "refseq_name": "translation factor Guf1, mitochondrial isoform 2", "refseq_ac": "NP_001297560", "gene_names_uniprotkb": "Guf1", "gene_names_refseq": "4631409J12; EF-4; Guf1; mtEF4", "protein_names_uniprotkb": "Translation factor Guf1, mitochondrial; 3.6.5.-; EF-4; Elongation factor 4 homolog; GTPase Guf1; Ribosomal back-translocase", "protein_names_refseq": "GTP-binding protein GUF1 homolog; GUF1 GTPase homolog; elongation factor 4 homolog; ribosomal back-translocase; translation factor Guf1, mitochondrial isoform 2; translation factor Guf1, mitochondrial", "tax_id": 10090, "disease": "West syndrome (Disease Ontology:DOID:0050562); developmental and epileptic encephalopathy 40 (Disease Ontology:DOID:0080427)", "pathway": " (mmu:231279)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27065197;33109704;35820727", "class_list": "", "function": "Genetic ablation of mitochondrial EF4 (mtEF4) in mice causes testis-specific dysfunction in oxidative phosphorylation, leading to male infertility., [RefSeq, PubMed]; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEN7;Q8BPS6", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C3X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7MCT6-1", "uniprot_id": "EKI2_MOUSE", "mass": 44567.0, "length": 385, "protein_name": "Ethanolamine kinase 2", "gene_name": "Etnk2", "organism": "Mouse", "refseq_name": "ethanolamine kinase 2 isoform 1", "refseq_ac": "NP_780652", "gene_names_uniprotkb": "Etnk2; Tuc1", "gene_names_refseq": "4933417N20Rik; EKI 2; Eki2; Etnk2; Tuc1", "protein_names_uniprotkb": "Ethanolamine kinase 2; 2.7.1.82; EKI 2; Ethanolamine kinase-like protein", "protein_names_refseq": "ethanolamine kinase 2 isoform 1; ethanolamine kinase-like protein; putative ethanolamine kinase", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:214253); (R-MMU-1483213)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15161093;16861741;18755794;21750661;34428180", "class_list": "", "function": "Catalyzes the ATP-dependent phosphorylation of ethanolamine to phosphoethanolamine (PubMed:16861741). Highly specific for ethanolamine phosphorylation and does not exhibit choline kinase activity (PubMed:16861741)., [UniProtKB, PubMed]; Expression restricted to the Sertoli cells of the developing testis., [RefSeq, PubMed]; No abnormalities were detected in the Eki2-deficient mice with regard to embryonic and adult testis morphology, differentiation, function, or fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNN6;D3Z771;Q6XRG2", "ec_number_list": "2.7.1.82;2.7.1.32", "go_molecular_function": "GO:0005524 ATP binding;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0035264 multicellular organism growth;GO:0001890 placenta development;GO:0009791 post-embryonic development;GO:0016310 phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A7MCT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AKM2-1", "uniprot_id": "HACD4_MOUSE", "mass": 27235.0, "length": 232, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "gene_name": "Hacd4", "organism": "Mouse", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a", "refseq_ac": "NP_080036", "gene_names_uniprotkb": "Hacd4; Hcad4; Ptplad2", "gene_names_refseq": "4933428I03Rik; Hacd4; Hcad4; Ptplad2", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; 4.2.1.134; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2", "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 2; protein tyrosine phosphatase-like protein PTPLAD2; protein-tyrosine phosphatase-like A domain-containing protein 2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform a; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66775); (R-MMU-75876)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKM1;Q8BG85;Q9CPS2", "ec_number_list": "4.2.1.134;1.1.1.n12;4.2.1.107;4.2.1.119", "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AKM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08580-1", "uniprot_id": "ERR1_MOUSE", "mass": 45464.0, "length": 422, "protein_name": "Steroid hormone receptor ERR1", "gene_name": "Esrra", "organism": "Mouse", "refseq_name": "steroid hormone receptor ERR1 isoform 1", "refseq_ac": "NP_031979", "gene_names_uniprotkb": "Esrra; Err1; Estrra; Nr3b1", "gene_names_refseq": "ERRalpha; Err1; Esrra; Estrra; Nr3b1", "protein_names_uniprotkb": "Steroid hormone receptor ERR1; ERR-alpha; Estrogen receptor-like 1; Estrogen-related receptor alpha; Nuclear receptor subfamily 3 group B member 1", "protein_names_refseq": "ERR-alpha; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1); estrogen receptor related 1; estrogen receptor-like 1; nuclear receptor subfamily 3 group B member 1; steroid hormone receptor ERR1 isoform 1", "tax_id": 10090, "disease": "azoospermia (Disease Ontology:DOID:14227); cancer (Disease Ontology:DOID:162); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:26379); (R-MMU-383280)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14585956;17242355;18063693;20484414;21183079;21190936;21750661;28572090;30084848;34428180;40997131;9271417;9460651", "class_list": "", "function": "Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRU9;Q3U110", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O08580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZI6-1", "uniprot_id": "GUCD1_MOUSE", "mass": 27264.0, "length": 239, "protein_name": "Protein GUCD1", "gene_name": "Gucd1", "organism": "Mouse", "refseq_name": "protein GUCD1 isoform 2", "refseq_ac": "NP_001334130", "gene_names_uniprotkb": "Gucd1; 1110038D17Rik", "gene_names_refseq": "1110038D17Rik; Gucd1", "protein_names_uniprotkb": "Protein GUCD1; Guanylyl cyclase domain-containing protein 1; Protein LLN4", "protein_names_refseq": "guanylyl cyclase domain-containing protein 1; protein GUCD1 isoform 2; protein GUCD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68778)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q147V8;Q3TZX7;Q80XN8;Q8BLZ0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D882-1", "uniprot_id": "F241B_MOUSE", "mass": 13118.0, "length": 120, "protein_name": "Protein FAM241B", "gene_name": "Fam241b", "organism": "Mouse", "refseq_name": "protein FAM241B", "refseq_ac": "NP_081527", "gene_names_uniprotkb": "Fam241b; 2010107G23Rik", "gene_names_refseq": "2010107G23Rik; Fam241b", "protein_names_uniprotkb": "Protein FAM241B", "protein_names_refseq": "protein FAM241B; uncharacterized protein C10orf35 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:69894)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in lysosome homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2A1-1", "uniprot_id": "GULP1_MOUSE", "mass": 34470.0, "length": 304, "protein_name": "PTB domain-containing engulfment adapter protein 1", "gene_name": "Gulp1", "organism": "Mouse", "refseq_name": "PTB domain-containing engulfment adapter protein 1", "refseq_ac": "NP_082726", "gene_names_uniprotkb": "Gulp1; Ced6", "gene_names_refseq": "3110030A04Rik; 5730529O06Rik; CED-6; Ced6; GULP; Gulp-2; Gulp1", "protein_names_uniprotkb": "PTB domain-containing engulfment adapter protein 1; Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP", "protein_names_refseq": "CED 6; PTB domain adapter protein CED-6; PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:70676)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11729193;12583998;17007823;17398097;18230608;19122200;21750661;35820727;36870066;38214103;38553249;38696649", "class_list": "", "function": "CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans., [RefSeq, PubMed]; GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells., [RefSeq, PubMed]; Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17beta-estradiol levels., [RefSeq, PubMed]; Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-beta/SMAD2/3 pathway., [RefSeq, PubMed]; In this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function, [RefSeq, PubMed]; Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6., [UniProtKB, PubMed]; Phosphatidylserine-recognizing SR-BI activates associated GULP; activated GULP induces MAPK phosphorylation; activated MAPK increases GTP-bound Rac1; and activated Rac1 induces a rearrangement of the actin cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CRV4;Q9CYD2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006869 lipid transport;GO:0006911 phagocytosis, engulfment;GO:0006915 apoptotic process;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K2A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03249-1", "uniprot_id": "GALT_MOUSE", "mass": 43232.0, "length": 379, "protein_name": "Galactose-1-phosphate uridylyltransferase", "gene_name": "Galt", "organism": "Mouse", "refseq_name": "galactose-1-phosphate uridylyltransferase isoform 1", "refseq_ac": "NP_057867", "gene_names_uniprotkb": "Galt", "gene_names_refseq": "Galt", "protein_names_uniprotkb": "Galactose-1-phosphate uridylyltransferase; 2.7.7.12; Gal-1-P uridylyltransferase; UDP-glucose--hexose-1-phosphate uridylyltransferase", "protein_names_refseq": "UDP-glucose--hexose-1-phosphate uridylyltransferase; gal-1-P uridylyltransferase; galactose-1-phosphate uridylyltransferase isoform 1; galactose-1-phosphate uridylyltransferase", "tax_id": 10090, "disease": "classic galactosemia (Disease Ontology:DOID:0111459); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (mmu:14430); (R-MMU-70370)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1427861;15862277;17433749;17975019;21750661;33199205", "class_list": "glycogene", "function": "Data show that PRL signals through the short form of PRL receptor RL, and causes, iin the absence of RL, a severe ovarian pathology by repressing the expression of FOXO3 and that of its target gene Galt. Erratum:[Mol Endocrinol. 2008 Dec;22(12):2766], [RefSeq, PubMed]; Effects of GALT deficiency and dietary galactose on UDP-glucose pyrophosphorylase and UDP-galactose pyrophosphorylase activity and uridine diphosphate glucose expression in liver of mice with homozygous deletion of the critical regions of galt., [RefSeq, PubMed]; Gray and white matter are both affected in classical galactosemia: An explorative study on the association between neuroimaging and clinical outcome., [RefSeq, PubMed]; Plays an important role in galactose metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The finding is consistent with the function of UDP galactose pyrophosphorylase as an alternate pathway of galactose metabolism., [RefSeq, PubMed]; The protein encoded by this gene is the second enzyme in the Leloir pathway, the metabolic pathway for D-galactose catabolism. It catalyzes the conversion of galactose-1-phosphate and uridine diphosphate-glucose to glucose-1-phosphate and uridine diphosphate galactose. Deficiency of this enzyme causes the genetic metabolic disorder galactosemia. Mice lacking this protein accumulate high levels of galactose and galactose-1 phosphate but are viable and fertile. This protein is negatively regulated through signaling by the polypeptide hormone prolactin, specifically via the short isoform of the prolactin receptor and the transcription factor Forkhead box O3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VQ7", "ec_number_list": "2.7.7.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061623 glycolytic process from galactose;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYY1-1", "uniprot_id": "I36RA_MOUSE", "mass": 17136.0, "length": 156, "protein_name": "Interleukin-36 receptor antagonist protein", "gene_name": "Il36rn", "organism": "Mouse", "refseq_name": "interleukin-36 receptor antagonist protein", "refseq_ac": "NP_001139559", "gene_names_uniprotkb": "Il36rn; Fil1d; Il1f5; Il1h3; Il1hy1", "gene_names_refseq": "Fil1delta; IL-36Ra; If36rn; Il-1h3; Il1f5; Il1hy1; Il36rn", "protein_names_uniprotkb": "Interleukin-36 receptor antagonist protein; IL-1 delta; IL-1F5; IL-1H3; IL-1HY1; IL-1L1; IL-36Ra; Interleukin-1 HY1; Interleukin-1 delta; Interleukin-1 family member 5; Interleukin-1 homolog 3; Interleukin-1-like protein 1", "protein_names_refseq": "IL-1 delta; IL-1F5; IL-1HY1; IL-1L1; interleukin 1 family, member 5 (delta); interleukin 1 receptor antagonist homolog 1; interleukin-1 HY1; interleukin-1 delta; interleukin-1 family member 5; interleukin-1 homolog 3; interleukin-1-like protein 1; interleukin-36 receptor antagonist protein", "tax_id": 10090, "disease": "pustular psoriasis 14 (Disease Ontology:DOID:0080474)", "pathway": " (mmu:54450); (R-MMU-9014826)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10744718;11093146;11466363;12974628;17908936;18284608;21750661;21860022;21965679;34428180;34699104", "class_list": "", "function": "Cutaneous ischemia-reperfusion injury is exacerbated by IL-36 receptor antagonist deficiency., [RefSeq, PubMed]; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIG2", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0032700 negative regulation of interleukin-17 production;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0019732 antifungal humoral response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QYY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1L3C1-1", "uniprot_id": "GAR5A_MOUSE", "mass": 24172.0, "length": 212, "protein_name": "Golgi-associated RAB2 interactor protein 5A", "gene_name": "Garin5a", "organism": "Mouse", "refseq_name": "Golgi-associated RAB2 interactor protein 5A isoform 1", "refseq_ac": "NP_082445", "gene_names_uniprotkb": "Garin5a; Fam71e1; Garil5", "gene_names_refseq": "0610007G24Rik; 1700021N13Rik; 1700021P22Rik; Fam71e1; GARI-L5; GARIL5; Garin5a", "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 5A; GARIL5; Golgi-associated RAB2B interactor-like 5", "protein_names_refseq": "Golgi associated RAB2 interactor protein 5A; Golgi-associated RAB2 interactor protein 5A isoform 1; Golgi-associated Rab2B interactor-like 5; Protein FAM71E1; family with sequence similarity 71, member E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75538)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28742876;28930687", "class_list": "", "function": "RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis., [UniProtKB, PubMed]; The RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKI6;Q0P5X9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0030317 flagellated sperm motility;GO:0000902 cell morphogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1L3C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIH5-1", "uniprot_id": "PLCG2_MOUSE", "mass": 147592.0, "length": 1265, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "gene_name": "Plcg2", "organism": "Mouse", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2", "refseq_ac": "NP_758489", "gene_names_uniprotkb": "Plcg2", "gene_names_refseq": "PLC-gamma-2; PLCgamma2; Plcg-2; Plcg2", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 3.1.4.11; PLC-gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-gamma-2", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C-gamma-2", "tax_id": 10090, "disease": "autoinflammation, antibody deficiency, and immune dysregulation syndrome (Disease Ontology:DOID:0070615); familial cold autoinflammatory syndrome 3 (Disease Ontology:DOID:0090064)", "pathway": " (mmu:234779); (R-MMU-114604); (R-MMU-166016); (R-MMU-1855204); (R-MMU-202433); (R-MMU-2029485); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-5607764); (R-MMU-5621480); (R-MMU-983695)", "pathway_count": 12, "publication_count": 12, "publication_id_list": "17947660;22291096;23478294;25988959;27609517;27992403;28368423;30237801;31249969;34428180;39627609;9312046", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBA8;Q3UQT0;Q8VE69", "ec_number_list": "3.1.4.11;2.7.1.153;2.7.1.137;2.7.11.1;2.7.10.2;2.7.10.1;2.3.2.27;3.1.3.48;3.6.5.5;3.6.5.2;3.1.3.86;3.1.3.56;3.1.3.36", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0019901 protein kinase binding;GO:0004629 phospholipase C activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:0032747 positive regulation of interleukin-23 production;GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0001878 response to yeast;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CIH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08537-1", "uniprot_id": "ESR2_MOUSE", "mass": 59070.0, "length": 530, "protein_name": "Estrogen receptor beta", "gene_name": "Esr2", "organism": "Mouse", "refseq_name": "estrogen receptor beta isoform 2", "refseq_ac": "NP_034287", "gene_names_uniprotkb": "Esr2; Estrb; Nr3a2", "gene_names_refseq": "ER[b]; ERbeta; Esr2; Estrb", "protein_names_uniprotkb": "Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2", "protein_names_refseq": "ER-beta; estrogen receptor beta isoform 2; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); ovarian dysgenesis 8 (Disease Ontology:DOID:0080500); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myasthenia gravis (Disease Ontology:DOID:437); pulmonary hypertension (Disease Ontology:DOID:6432); adenoma (Disease Ontology:DOID:657); rheumatoid arthritis (Disease Ontology:DOID:7148); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:13983); (R-MMU-1257604); (R-MMU-383280); (R-MMU-6811558); (R-MMU-8939211); (R-MMU-9009391)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10230404;10788465;10995228;11150304;11704680;11878304;21750661;30084848;9058381;9192892;9280064;9607809;9685228", "class_list": "", "function": "Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 39, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RUC6;E9QKX7;O35635;O70519;Q8BG65;Q91Z86", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0043025 neuronal cell body", "go_biological_process": "GO:0060743 epithelial cell maturation involved in prostate gland development;GO:2000252 negative regulation of feeding behavior;GO:0048521 negative regulation of behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O08537-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKN5-1", "uniprot_id": "GCP5_MOUSE", "mass": 117977.0, "length": 1024, "protein_name": "Gamma-tubulin complex component 5", "gene_name": "Tubgcp5", "organism": "Mouse", "refseq_name": "gamma-tubulin complex component 5 isoform 1", "refseq_ac": "NP_666302", "gene_names_uniprotkb": "Tubgcp5; Kiaa1899", "gene_names_refseq": "B130010C12Rik; GCP5; Tubgcp5; mKIAA1899", "protein_names_uniprotkb": "Gamma-tubulin complex component 5; GCP-5", "protein_names_refseq": "gamma-tubulin complex component 5 isoform 1; gamma-tubulin complex component 5; tubulin, gamma complex associated protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:233276); (R-MMU-380270); (R-MMU-380320)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14508708;21750661", "class_list": "", "function": "Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB]; Indentification on mouse chromosome 7C, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8X5;Q69Z75;Q8BLJ9;Q8C083", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BKN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TNH5-1", "uniprot_id": "ARB2A_MOUSE", "mass": 48072.0, "length": 417, "protein_name": "Cotranscriptional regulator ARB2A", "gene_name": "Arb2a", "organism": "Mouse", "refseq_name": "cotranscriptional regulator ARB2A isoform 3", "refseq_ac": "NP_001156892", "gene_names_uniprotkb": "Arb2a; Fam172a", "gene_names_refseq": "1110033M05Rik; 2610318O14Rik; 53-E6; 9430037D06Rik; Arb2a; Fam172a; pEN87", "protein_names_uniprotkb": "Cotranscriptional regulator ARB2A; Cotranscriptional regulator FAM172A; Protein FAM172A", "protein_names_refseq": "cotranscriptional regulator ARB2A isoform 3; cotranscriptional regulator ARB2A; cotranscriptional regulator FAM172A; family with sequence similarity 172, member A; protein FAM172A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68675)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;26495903;29311329;34428180;35129866", "class_list": "", "function": "CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms., [RefSeq, PubMed]; Key role in the regulation of cotranscriptional alternative splicing in CHARGE syndrome model, [RefSeq, PubMed]; Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface (PubMed:29311329). May have hydrolase activity (PubMed:29311329)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLW0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0014032 neural crest cell development;GO:0031048 regulatory ncRNA-mediated heterochromatin formation;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TNH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D733-1", "uniprot_id": "GP2_MOUSE", "mass": 59154.0, "length": 531, "protein_name": "Pancreatic secretory granule membrane major glycoprotein GP2", "gene_name": "Gp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:67133); (R-MMU-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19907495;21750661", "class_list": "", "function": "Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue;GO:1990266 neutrophil migration;GO:0002251 organ or tissue specific immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WJ1-1", "uniprot_id": "GGN_MOUSE", "mass": 68892.0, "length": 673, "protein_name": "Gametogenetin", "gene_name": "Ggn", "organism": "Mouse", "refseq_name": "gametogenetin isoform 1", "refseq_ac": "NP_874353", "gene_names_uniprotkb": "Ggn", "gene_names_refseq": "Ggn", "protein_names_uniprotkb": "Gametogenetin", "protein_names_refseq": "gametogenetin isoform 1", "tax_id": 10090, "disease": "spermatogenic failure 69 (Disease Ontology:DOID:0070568)", "pathway": " (mmu:243897)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12574169;15642376;15892049;21750661;23451117;25428506;30055035", "class_list": "", "function": "May be involved in spermatogenesis., [UniProtKB, PubMed]; Results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos., [RefSeq, PubMed]; These data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBP4;Q80WI9;Q80WJ0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006302 double-strand break repair;GO:0008104 intracellular protein localization;GO:0007566 embryo implantation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80WJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43883-1", "uniprot_id": "PLIN2_MOUSE", "mass": 46646.0, "length": 425, "protein_name": "Perilipin-2", "gene_name": "Plin2", "organism": "Mouse", "refseq_name": "perilipin-2 isoform 1", "refseq_ac": "NP_031434", "gene_names_uniprotkb": "Plin2; Adfp; Adrp", "gene_names_refseq": "ADPH; Adfp; Adrp; Plin2", "protein_names_uniprotkb": "Perilipin-2; ADRP; Adipophilin; Adipose differentiation-related protein", "protein_names_refseq": "adipophilin; adipose differentiation-related protein; perilipin-2 isoform 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11520)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11978849;12562852;1518805;21750661;25428506;30016717;30084848;31219806;32782141;34428180;36084651;36210013;36852467;37195149;37453647;8325636;9392423", "class_list": "", "function": "Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3Q8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:0015909 long-chain fatty acid transport;GO:1905691 lipid droplet disassembly", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P43883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47856-1", "uniprot_id": "GFPT1_MOUSE", "mass": 78539.0, "length": 697, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "gene_name": "Gfpt1", "organism": "Mouse", "refseq_name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "refseq_ac": "NP_038556", "gene_names_uniprotkb": "Gfpt1; Gfpt", "gene_names_refseq": "2810423A18Rik; GFAT1m; GFAT1; GFAT; GFA; Gfpt1; Gfpt", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; 2.6.1.16; D-fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Glutamine:fructose-6-phosphate amidotransferase 1; Hexosephosphate aminotransferase 1", "protein_names_refseq": "D-fructose-6-phosphate amidotransferase 1; GFAT 1; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine:fructose-6-phosphate amidotransferase 1; hexosephosphate aminotransferase 1", "tax_id": 10090, "disease": "congenital myasthenic syndrome 12 (Disease Ontology:DOID:0110660); familial hyperlipidemia (Disease Ontology:DOID:1168); Machado-Joseph disease (Disease Ontology:DOID:1440); hyperinsulinism (Disease Ontology:DOID:2018); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14583); (R-MMU-446210)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11679416;15133036;17242355;18630941;21183079;21750661;23395176;25153642;25428506;28528544;31219806;32019926;34428180;35820727;38903011;39456185;8144040", "class_list": "glycogene", "function": "A Deficiency in Glutamine-Fructose-6-Phosphate Transaminase 1 (Gfpt1) in Skeletal Muscle Results in Reduced Glycosylation of the Delta Subunit of the Nicotinic Acetylcholine Receptor (AChRdelta). Publication Status: Online-Only, [RefSeq, PubMed]; Muscle-specific lack of Gfpt1 triggers ER stress to alleviate misfolded protein accumulation., [RefSeq, PubMed]; Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:23395176). Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop (PubMed:32019926). Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling (By similarity). Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (PubMed:23395176)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XG9;Q99LP7;Q99MJ4", "ec_number_list": "2.6.1.16", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0030246 carbohydrate binding;GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:0006042 glucosamine biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0032922 circadian regulation of gene expression;GO:0006047 UDP-N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P47856-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0D2-1", "uniprot_id": "HABP2_MOUSE", "mass": 62357.0, "length": 558, "protein_name": "Factor VII-activating protease", "gene_name": "Habp2", "organism": "Mouse", "refseq_name": "factor VII-activating protease isoform 2 precursor", "refseq_ac": "NP_666213", "gene_names_uniprotkb": "Habp2", "gene_names_refseq": "FSAP; HABP; HGFAL; Habp2; PHBP", "protein_names_uniprotkb": "Factor VII-activating protease; 3.4.21.-; FSAP; FVII activator; Hepatocyte growth factor activator-like protein; Hyaluronan-binding protein 2; PHBP; Plasma hyaluronan-binding protein", "protein_names_refseq": "FVII activator; factor VII-activating protease isoform 2 precursor; factor VII-activating protease; hepatocyte growth factor activator-like protein; hyaduronic acid-binding protein 2; hyaluronan-binding protein 2; plasma hyaluronan-binding protein", "tax_id": 10090, "disease": "thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:226243)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;37294185;9401717", "class_list": "glycogene", "function": "Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K0D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51163-1", "uniprot_id": "HEM4_MOUSE", "mass": 28504.0, "length": 265, "protein_name": "Uroporphyrinogen-III synthase", "gene_name": "Uros", "organism": "Mouse", "refseq_name": "uroporphyrinogen-III synthase isoform 1", "refseq_ac": "NP_001289014", "gene_names_uniprotkb": "Uros; Uros3", "gene_names_refseq": "UROIIIS; Uros3; Uros", "protein_names_uniprotkb": "Uroporphyrinogen-III synthase; 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; UROIIIS; UROS; Uroporphyrinogen-III cosynthase", "protein_names_refseq": "URO-synthase; hydroxymethylbilane hydrolyase (cyclizing); uroporphyrinogen-III cosynthase; uroporphyrinogen-III cosynthetase; uroporphyrinogen-III synthase isoform 1", "tax_id": 10090, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271)", "pathway": " (mmu:22276); (R-MMU-189451)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21365124;21750661;24145442;7607680;7873885", "class_list": "", "function": "Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:7607680). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data show that in adult UROS C73R mice, spleen and liver weights were 8.2- and 1.5-fold increased, respectively., [RefSeq, PubMed]; The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.75", "go_molecular_function": "GO:0005542 folic acid binding;GO:0004852 uroporphyrinogen-III synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0070541 response to platinum ion;GO:0071243 cellular response to arsenic-containing substance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14432-1", "uniprot_id": "HA1T_MOUSE", "mass": 43479.0, "length": 384, "protein_name": "H-2 class I histocompatibility antigen, TLA(B) alpha chain", "gene_name": "H2-T3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-T3", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, TLA(B) alpha chain; MHC thymus leukemia antigen", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1236974); (R-MMU-1236977); (R-MMU-198933); (R-MMU-6798695); (R-MMU-983170)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1339405;21750661;2410925;34428180;3456611;3894562", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P14433;Q31194;Q31203", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09172-1", "uniprot_id": "GSH0_MOUSE", "mass": 30535.0, "length": 274, "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "Gclm", "organism": "Mouse", "refseq_name": "glutamate--cysteine ligase regulatory subunit", "refseq_ac": "NP_032155", "gene_names_uniprotkb": "Gclm; Glclr", "gene_names_refseq": "Gclm; Gcmc; Glclr", "protein_names_uniprotkb": "Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit", "protein_names_refseq": "GCS light chain; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; glutamate--cysteine ligase regulatory subunit", "tax_id": 10090, "disease": "myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:14630); (R-MMU-174403)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21540332;21750661;22645316;25153642;28135057;28528544;35820727;37453647;38340316;9294003", "class_list": "", "function": "Nuclear factor erythroid 2-related factor 2 promotes radioresistance by regulating glutamate-cysteine ligase modifier subunit and its unique immunoinvasive pattern. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035226 glutamate-cysteine ligase catalytic subunit binding;GO:0044877 protein-containing complex binding;GO:0004357 glutamate-cysteine ligase activity;GO:1990609 glutamate-cysteine ligase regulator activity", "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0051900 regulation of mitochondrial depolarization;GO:0097069 cellular response to thyroxine stimulus;GO:0035733 hepatic stellate cell activation;GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O09172-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9R9-1", "uniprot_id": "F186A_MOUSE", "mass": 194550.0, "length": 1790, "protein_name": "Protein FAM186A", "gene_name": "FAM186A; Fam186a", "organism": "Mouse", "refseq_name": "protein FAM186A isoform 2", "refseq_ac": "NP_082456", "gene_names_uniprotkb": "FAM186A; Fam186a; Gm920", "gene_names_refseq": "1700030F18Rik; Fam186a; Gm920", "protein_names_uniprotkb": "Protein FAM186A", "protein_names_refseq": "protein FAM186A isoform 2; protein FAM186A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72277)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 27, "predicted_n_glycosites": 0, "predicted_o_glycosites": 27, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 27, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D9R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1F8-1", "uniprot_id": "EPHX3_MOUSE", "mass": 41853.0, "length": 367, "protein_name": "Epoxide hydrolase 3", "gene_name": "Ephx3", "organism": "Mouse", "refseq_name": "epoxide hydrolase 3 isoform 1", "refseq_ac": "NP_001028335", "gene_names_uniprotkb": "Ephx3; Abhd9", "gene_names_refseq": "2310063B19Rik; Abhd9; EH3; Ephx3", "protein_names_uniprotkb": "Epoxide hydrolase 3; 3.3.2.10; Abhydrolase domain-containing protein 9; EH3", "protein_names_refseq": "abhydrolase domain-containing protein 9; epoxide hydrolase 3 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71932)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22798687;28384353;33334892", "class_list": "", "function": "Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin., [UniProtKB, UniProtKB]; Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function., [RefSeq, PubMed]; Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.3.2.10;3.1.3.76;3.3.2.9", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004301 epoxide hydrolase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0097176 epoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V1F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61626-1", "uniprot_id": "GRIK5_MOUSE", "mass": 109276.0, "length": 979, "protein_name": "Glutamate receptor ionotropic, kainate 5", "gene_name": "Grik5", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, kainate 5 isoform 1 precursor", "refseq_ac": "NP_032194", "gene_names_uniprotkb": "Grik5", "gene_names_refseq": "GluK5; GluRgamma2; Grik5; KA2", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 5; GluK5; GluR gamma-2; Glutamate receptor KA-2; Glutamate receptor gamma-2; KA2", "protein_names_refseq": "gluR gamma-2; glutamate receptor KA-2; glutamate receptor gamma-2; glutamate receptor ionotropic, kainate 5 isoform 1 precursor; glutamate receptor ionotropic, kainate 5", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (mmu:14809); (R-MMU-451308)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12954862;1310861;21750661;33300544;35820727", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK2 subunit (PubMed:1310861). Can form functional heteromeric receptors with GRIK1 and GRIK3 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "G5E822", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0060079 excitatory postsynaptic potential;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q61626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC19-1", "uniprot_id": "HEM1_MOUSE", "mass": 71018.0, "length": 642, "protein_name": "5-aminolevulinate synthase, non-specific, mitochondrial", "gene_name": "Alas1", "organism": "Mouse", "refseq_name": "5-aminolevulinate synthase, non-specific, mitochondrial precursor", "refseq_ac": "NP_001278764", "gene_names_uniprotkb": "Alas1", "gene_names_refseq": "ALAS-N; ALAS; Alas-1; Alas-h; Alas1", "protein_names_uniprotkb": "5-aminolevulinate synthase, non-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 1; ALAS-H; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1", "protein_names_refseq": "5-aminolevulinate synthase, non-specific, mitochondrial precursor; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; aminolevulinate synthase H; delta-ALA synthase 1; delta-aminolevulinate synthase 1; succinyl-CoA: glycine C-succinyl transferase", "tax_id": 10090, "disease": "porphyria (Disease Ontology:DOID:13268); erythropoietic protoporphyria (Disease Ontology:DOID:13270); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:11655); (R-MMU-189451); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12881517;21750661;22872234;24821812;31219806;33307066;34428180", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver., [RefSeq, PubMed]; Identified a drug-responsive enhancer in the ALAS1 gene, [RefSeq, PubMed]; RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64453", "ec_number_list": "3.5.3.1;1.8.1.4;5.3.3.21;3.1.2.-;3.1.2.2;3.4.21.92;1.1.1.37;2.3.1.37;4.98.1.1;1.2.4.1;3.6.4.10;5.3.3.8;1.2.1.3;1.1.1.42;7.1.2.2;5.6.1.7;4.2.1.2;1.2.4.2;1.1.1.35;1.1.1.30;2.7.11.2;2.3.1.9;7.1.1.2;1.1.1.38;4.2.1.3;1.2.1.36;1.7.1.-;1.2.1.28;2.3.3.1;2.8.3.5;2.3.1.41;1.1.1.41;1.3.8.5;6.2.1.-;6.2.1.4", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0003870 5-aminolevulinate synthase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0051591 response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VC19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHG0-1", "uniprot_id": "FMO4_MOUSE", "mass": 63792.0, "length": 560, "protein_name": "Dimethylaniline monooxygenase [N-oxide-forming] 4", "gene_name": "Fmo4", "organism": "Mouse", "refseq_name": "dimethylaniline monooxygenase [N-oxide-forming] 4", "refseq_ac": "NP_659127", "gene_names_uniprotkb": "Fmo4", "gene_names_refseq": "D1Ertd532e; Fmo4", "protein_names_uniprotkb": "Dimethylaniline monooxygenase [N-oxide-forming] 4; 1.14.13.8; Dimethylaniline oxidase 4; FMO 4; Hepatic flavin-containing monooxygenase 4", "protein_names_refseq": "FMO 4; dimethylaniline monooxygenase [N-oxide-forming] 4; dimethylaniline oxidase 4; hepatic flavin-containing monooxygenase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:226564)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19307449;21750661;24792439", "class_list": "", "function": "Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT)., [RefSeq, PubMed]; Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes., [RefSeq, PubMed]; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.-.-.-;1.14.13.148;1.14.13.8;1.14.13.32;1.6.3.1", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0097009 energy homeostasis;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZJ5-1", "uniprot_id": "EREP3_MOUSE", "mass": 72016.0, "length": 669, "protein_name": "Protein ENTREP3", "gene_name": "Entrep3", "organism": "Mouse", "refseq_name": "protein ENTREP3 isoform 1", "refseq_ac": "NP_001014995", "gene_names_uniprotkb": "Entrep3; Fam189b", "gene_names_refseq": "1110013L07Rik; Entrep3; Fam189b", "protein_names_uniprotkb": "Protein ENTREP3; Endosomal transmembrane epsin interactor 3", "protein_names_refseq": "family with sequence similarity 189, member B; protein ENTREP3 isoform 1; protein ENTREP3; protein FAM189B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68521)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5HZJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXP4-1", "uniprot_id": "DONS_MOUSE", "mass": 61987.0, "length": 560, "protein_name": "Protein downstream neighbor of Son", "gene_name": "Donson", "organism": "Mouse", "refseq_name": "protein downstream neighbor of Son", "refseq_ac": "NP_068366", "gene_names_uniprotkb": "Donson; ORF60", "gene_names_refseq": "1110025J21Rik; Donson; ORF60", "protein_names_uniprotkb": "Protein downstream neighbor of Son; Protein 3SG", "protein_names_refseq": "protein 3SG; protein downstream neighbor of Son", "tax_id": 10090, "disease": "microcephaly, short stature, and limb abnormalities (Disease Ontology:DOID:0081431); microcephaly-micromelia syndrome (Disease Ontology:DOID:0081432); syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:60364)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10950926;21750661;28630177;33739968", "class_list": "", "function": "Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability., [UniProtKB, UniProtKB]; The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80V93;Q8BV55", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030894 replisome;GO:0005634 nucleus;GO:0005657 replication fork", "go_biological_process": "GO:0006260 DNA replication;GO:0000077 DNA damage checkpoint signaling;GO:0007095 mitotic G2 DNA damage checkpoint signaling;GO:0006270 DNA replication initiation;GO:0033260 nuclear DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QXP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01910-1", "uniprot_id": "HA2K_MOUSE", "mass": 28351.0, "length": 256, "protein_name": "H-2 class II histocompatibility antigen, A-K alpha chain", "gene_name": "H2-Aa", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Aa", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, A-K alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); marginal zone lymphoma (Disease Ontology:DOID:0050748); rheumatic heart disease (Disease Ontology:DOID:0050827); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); stroke (Disease Ontology:DOID:0051061); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); lupus nephritis (Disease Ontology:DOID:0080162); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); stomach cancer (Disease Ontology:DOID:10534); glucose intolerance (Disease Ontology:DOID:10603); celiac disease (Disease Ontology:DOID:10608); hypertension (Disease Ontology:DOID:10763); lepromatous leprosy (Disease Ontology:DOID:10887); membranous glomerulonephritis (Disease Ontology:DOID:10976); IgA vasculitis (Disease Ontology:DOID:11123); rhinoscleroma (Disease Ontology:DOID:11336); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); congenital toxoplasmosis (Disease Ontology:DOID:13336); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); colon carcinoma (Disease Ontology:DOID:1520); diffuse scleroderma (Disease Ontology:DOID:1580); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); multiple sclerosis (Disease Ontology:DOID:2377); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); antiphospholipid syndrome (Disease Ontology:DOID:2988); brain infarction (Disease Ontology:DOID:3454); gastric adenocarcinoma (Disease Ontology:DOID:3717); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); myasthenia gravis (Disease Ontology:DOID:437); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); abdominal aortic aneurysm (Disease Ontology:DOID:7693); arthritis (Disease Ontology:DOID:848); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); psoriasis (Disease Ontology:DOID:8893); visceral leishmaniasis (Disease Ontology:DOID:9146); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14960); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-2132295); (R-MMU-389948)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12589760;18250455;1855817;20173027;21750661;2581258;28011936;29187734;3137158;32152506;33725478;34428180;3500915;37507081;3980466;6300851;6309407;9529148", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 67, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042605 peptide antigen binding;GO:0023026 MHC class II protein complex binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0042613 MHC class II protein complex;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002250 adaptive immune response;GO:0045582 positive regulation of T cell differentiation;GO:0002684 positive regulation of immune system process;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P01910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07903-1", "uniprot_id": "ERCC1_MOUSE", "mass": 32910.0, "length": 298, "protein_name": "DNA excision repair protein ERCC-1", "gene_name": "Ercc1", "organism": "Mouse", "refseq_name": "DNA excision repair protein ERCC-1 isoform b", "refseq_ac": "NP_001120796", "gene_names_uniprotkb": "Ercc1; Ercc-1", "gene_names_refseq": "Ercc-1; Ercc1", "protein_names_uniprotkb": "DNA excision repair protein ERCC-1", "protein_names_refseq": "DNA excision repair protein ERCC-1 isoform b; DNA excision repair protein ERCC-1", "tax_id": 10090, "disease": "XFE progeroid syndrome (Disease Ontology:DOID:0060590); cerebrooculofacioskeletal syndrome 4 (Disease Ontology:DOID:0080914); stomach cancer (Disease Ontology:DOID:10534); kidney failure (Disease Ontology:DOID:1074); azoospermia (Disease Ontology:DOID:14227); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myelofibrosis (Disease Ontology:DOID:4971); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13870); (R-MMU-5685938); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6783310)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "21750661;31219806;3290851;38428304;38451018", "class_list": "", "function": "Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response., [RefSeq, PubMed]; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity)., [UniProtKB, UniProtKB]; Podocyte Ercc1 is indispensable for glomerular integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VP3", "ec_number_list": "", "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0001094 TFIID-class transcription factor complex binding;GO:0003697 single-stranded DNA binding;GO:1990841 promoter-specific chromatin binding;GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0070522 ERCC4-ERCC1 complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006312 mitotic recombination;GO:0000720 pyrimidine dimer repair by nucleotide-excision repair;GO:0006949 syncytium formation;GO:0032205 negative regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921M7-1", "uniprot_id": "CYRIB_MOUSE", "mass": 36776.0, "length": 324, "protein_name": "CYFIP-related Rac1 interactor B", "gene_name": "Cyrib", "organism": "Mouse", "refseq_name": "CYFIP-related Rac1 interactor B isoform 1", "refseq_ac": "NP_659095", "gene_names_uniprotkb": "Cyrib; Cyri; Fam49b", "gene_names_refseq": "0910001A06Rik; Cyrib; Fam49b", "protein_names_uniprotkb": "CYFIP-related Rac1 interactor B; Protein FAM49B", "protein_names_refseq": "CYFIP-related Rac1 interactor B isoform 1; family with sequence similarity 49, member B; protein FAM49B", "tax_id": 10090, "disease": "", "pathway": " (mmu:223601); (R-MMU-114608)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22522492;29059164;29187734;30899004;31219806;31285585;34428180;35131594;36210013;38391912;38712822;39158947", "class_list": "", "function": "CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. Publication Status: Online-Only, [RefSeq, PubMed]; Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets. Publication Status: Online-Only, [RefSeq, PubMed]; FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner., [RefSeq, PubMed]; Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (By similarity). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (PubMed:31285585). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0023030 MHC class Ib protein binding, via antigen binding groove", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0050852 T cell receptor signaling pathway;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q921M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R180-1", "uniprot_id": "ERO1A_MOUSE", "mass": 54084.0, "length": 464, "protein_name": "ERO1-like protein alpha", "gene_name": "Ero1a", "organism": "Mouse", "refseq_name": "ERO1-like protein alpha precursor", "refseq_ac": "NP_056589", "gene_names_uniprotkb": "Ero1a; Ero1l", "gene_names_refseq": "ERO1-L; Ero1a; Ero1l", "protein_names_uniprotkb": "ERO1-like protein alpha; 1.8.3.2; ERO1-L-alpha; ERO1-L; Endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; Oxidoreductin-1-L-alpha", "protein_names_refseq": "ERO1-L-alpha; ERO1-like protein alpha precursor; ERO1-like protein alpha; endoplasmic oxidoreductin-1-like protein; endoplasmic reticulum oxidation 1; endoplasmic reticulum oxidoreductase alpha; endoplasmic reticulum oxidoreductin-1-like protein; oxidoreductin-1-L-alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:50527); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10671517;12752442;19752026;20308425;21750661;29858230;30084848;30899004;31219806;35347798;37132383;37828378;38402623", "class_list": "", "function": "A Critical Role for ERO1alpha in Arterial Thrombosis and Ischemic Stroke., [RefSeq, PubMed]; Describes mouse Ero1-l in addition to the human gene., [RefSeq, PubMed]; Homocysteine facilitates endoplasmic reticulum stress and apoptosis of hepatocytes by suppressing ERO1alpha expression via cooperation between DNMT1 and G9a., [RefSeq, PubMed]; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum (PubMed:20308425). Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (By similarity). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1 (PubMed:19752026)., [UniProtKB, PubMed, PubMed, UniProtKB]; Oxygen regulation of ERO1-Lalpha expression likely maintains the transfer rate of oxidizing equivalents to PDI in situations of an altered cellular redox state induced by changes in the cellular oxygen tension, [RefSeq, PubMed]; SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA., [RefSeq, PubMed]; This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV47;Q9QY03", "ec_number_list": "5.3.4.1;1.8.3.2", "go_molecular_function": "GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030198 extracellular matrix organization;GO:0050873 brown fat cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8R180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFT2-1", "uniprot_id": "HAUS4_MOUSE", "mass": 42197.0, "length": 363, "protein_name": "HAUS augmin-like complex subunit 4", "gene_name": "Haus4", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 4", "refseq_ac": "NP_663437", "gene_names_uniprotkb": "Haus4; D14Ertd500e", "gene_names_refseq": "9430093H08Rik; D14Ertd500e; Haus4", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 4", "protein_names_refseq": "HAUS augmin-like complex subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:219072); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KI1", "ec_number_list": "", "go_molecular_function": "GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005813 centrosome;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BFT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI03-1", "uniprot_id": "FWCH1_MOUSE", "mass": 77096.0, "length": 673, "protein_name": "FLYWCH-type zinc finger-containing protein 1", "gene_name": "Flywch1", "organism": "Mouse", "refseq_name": "FLYWCH-type zinc finger-containing protein 1 isoform 2", "refseq_ac": "NP_722486", "gene_names_uniprotkb": "Flywch1; Kiaa1552", "gene_names_refseq": "E030034P13Rik; Flywch1; mKIAA1552", "protein_names_uniprotkb": "FLYWCH-type zinc finger-containing protein 1", "protein_names_refseq": "FLYWCH-type zinc finger-containing protein 1 isoform 2; FLYWCH-type zinc finger-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224613)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;30779550;34428180;40997131", "class_list": "", "function": "Transcription cofactor. Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding. May play a role in DNA-damage response signaling. Binds specifically to DNA sequences at peri-centromeric chromatin loci., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QKQ2;Q3TH83;Q6ZPN0;Q8C792", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005667 transcription regulator complex;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CI03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3V5-1", "uniprot_id": "FSIP1_MOUSE", "mass": 48968.0, "length": 435, "protein_name": "Fibrous sheath-interacting protein 1", "gene_name": "Fsip1", "organism": "Mouse", "refseq_name": "fibrous sheath-interacting protein 1 isoform 2", "refseq_ac": "NP_082035", "gene_names_uniprotkb": "Fsip1", "gene_names_refseq": "1700012M13Rik; 4933432K11Rik; Fsip1", "protein_names_uniprotkb": "Fibrous sheath-interacting protein 1", "protein_names_refseq": "fibrous sheath-interacting protein 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71313)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12606363;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4I9;Q9DAD8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007338 single fertilization;GO:0048873 homeostasis of number of cells within a tissue;GO:0060271 cilium assembly;GO:0006900 vesicle budding from membrane;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VAH7-1", "uniprot_id": "HECA2_MOUSE", "mass": 51421.0, "length": 463, "protein_name": "HEPACAM family member 2", "gene_name": "Hepacam2", "organism": "Mouse", "refseq_name": "HEPACAM family member 2 isoform 1 precursor", "refseq_ac": "NP_849230", "gene_names_uniprotkb": "Hepacam2; Miki", "gene_names_refseq": "Hepacam2", "protein_names_uniprotkb": "HEPACAM family member 2; Mitotic kinetics regulator", "protein_names_refseq": "HEPACAM family member 2 isoform 1 precursor; mitotic kinetics regulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:101202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VAH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTN0-1", "uniprot_id": "GGPPS_MOUSE", "mass": 34707.0, "length": 300, "protein_name": "Geranylgeranyl pyrophosphate synthase", "gene_name": "Ggps1", "organism": "Mouse", "refseq_name": "geranylgeranyl pyrophosphate synthase isoform 1", "refseq_ac": "NP_001318048", "gene_names_uniprotkb": "Ggps1", "gene_names_refseq": "1810026C22Rik; 9530089B04Rik; GGPPS; Ggps1", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.-; 2.5.1.10; 2.5.1.1; 2.5.1.29; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; GGPP synthase; GGPPSase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "(2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPP synthetase; GGPPSase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyltranstransferase; geranylgeranyl pyrophosphate synthase isoform 1; geranylgeranyl pyrophosphate synthase; geranylgeranyl pyrophosphate synthetase; geranyltranstransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:14593); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10101267;16978613;21224049;21750661;32403198;37827345;39229897", "class_list": "", "function": "Catalyzes the trans-addition of the three molecules of isopentenyl diphosphate (IPP) onto dimethylallyl pyrophosphate (DMAPP) to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins., [UniProtKB, UniProtKB]; CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway., [RefSeq, PubMed]; Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease., [RefSeq, PubMed]; GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved., [RefSeq, PubMed]; These results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.1;2.5.1.10;2.5.1.29;2.5.1.-", "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0006720 isoprenoid metabolic process;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WTN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WA3-1", "uniprot_id": "HDA11_MOUSE", "mass": 39157.0, "length": 347, "protein_name": "Histone deacetylase 11", "gene_name": "Hdac11", "organism": "Mouse", "refseq_name": "histone deacetylase 11", "refseq_ac": "NP_659168", "gene_names_uniprotkb": "Hdac11", "gene_names_refseq": "Hdac11", "protein_names_uniprotkb": "Histone deacetylase 11; 3.5.1.98; HD11", "protein_names_refseq": "HD11; histone deacetylase 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:232232); (R-MMU-350054)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16452087;17893925;21750661;36087429;37567072;38110164", "class_list": "", "function": "Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation., [RefSeq, PubMed]; HDAC11 deficiency resists obesity by converting adipose-derived stem cells into brown adipocyte-like cells., [RefSeq, PubMed]; HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3., [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity)., [UniProtKB]; Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.-;3.5.1.98;3.5.1.48;3.5.1.62", "go_molecular_function": "GO:0004407 histone deacetylase activity;GO:0140297 DNA-binding transcription factor binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0040029 epigenetic regulation of gene expression;GO:0014003 oligodendrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91WA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5E4-1", "uniprot_id": "DRC3_MOUSE", "mass": 60827.0, "length": 523, "protein_name": "Dynein regulatory complex subunit 3", "gene_name": "Drc3", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 3", "refseq_ac": "NP_083320", "gene_names_uniprotkb": "Drc3; Lrrc48", "gene_names_refseq": "4930449E07Rik; Drc3; Lrrc48; m6Bei", "protein_names_uniprotkb": "Dynein regulatory complex subunit 3; Leucine-rich repeat-containing protein 48", "protein_names_refseq": "dynein regulatory complex subunit 3; leucine rich repeat containing 48; leucine-rich repeat-containing protein 48; novel Leucine Rich Repeat domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74665)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;25428506;27261005;28630322;31219806;31961863;34428180;36210013;36627292", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations in Lrrc48 cause hydrocephalus, laterality defects, and sinusitis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097545 axonemal doublet microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D5E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UDW8-1", "uniprot_id": "HGNAT_MOUSE", "mass": 72504.0, "length": 656, "protein_name": "Heparan-alpha-glucosaminide N-acetyltransferase", "gene_name": "Hgsnat", "organism": "Mouse", "refseq_name": "heparan-alpha-glucosaminide N-acetyltransferase precursor", "refseq_ac": "NP_084160", "gene_names_uniprotkb": "Hgsnat; D8Ertd354e; Tmem76", "gene_names_refseq": "9430010M12Rik; D8Ertd354e; Hgsnat; Tmem76", "protein_names_uniprotkb": "Heparan-alpha-glucosaminide N-acetyltransferase; 2.3.1.78; Transmembrane protein 76", "protein_names_refseq": "heparan-alpha-glucosaminide N-acetyltransferase precursor; transmembrane protein 76", "tax_id": 10090, "disease": "retinitis pigmentosa 73 (Disease Ontology:DOID:0110389); mucopolysaccharidosis type IIIC (Disease Ontology:DOID:0111393); mucopolysaccharidosis III (Disease Ontology:DOID:12801)", "pathway": " (mmu:52120); (R-MMU-2024096); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16960811;17947660;19349973;21750661;25859010;30899004;34428180", "class_list": "glycogene", "function": "Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QNP9;Q3TWK5;Q8CBU7;Q8CIE1", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;1.1.1.-;3.2.1.20;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0016746 acyltransferase activity;GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0007041 lysosomal transport;GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UDW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97785-1", "uniprot_id": "GFRA1_MOUSE", "mass": 51752.0, "length": 468, "protein_name": "GDNF family receptor alpha-1", "gene_name": "Gfra1", "organism": "Mouse", "refseq_name": "GDNF family receptor alpha-1 isoform 2 precursor", "refseq_ac": "NP_001272386", "gene_names_uniprotkb": "Gfra1; Gdnfra; Trnr1", "gene_names_refseq": "GFRalpha-1; Gfra1", "protein_names_uniprotkb": "GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; TGF-beta-related neurotrophic factor receptor 1", "protein_names_refseq": "GDNF family receptor alpha-1 isoform 2 precursor; GDNF family receptor alpha-1; GDNF receptor alpha 1 (GFRa-1); GDNF receptor alpha 1c; GDNF receptor alpha 1d; GDNF receptor alpha 1e; GDNFR-alpha-1; GFR alpha-1; TGF-beta-related neurotrophic factor receptor 1", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); sciatic neuropathy (Disease Ontology:DOID:11446); renal agenesis (Disease Ontology:DOID:14766); brain ischemia (Disease Ontology:DOID:2316); Churg-Strauss syndrome (Disease Ontology:DOID:3049); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (mmu:14585); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23333276;37828378;9592044", "class_list": "", "function": "Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor., [UniProtKB, UniProtKB]; This gene encodes a transmembrane protein that functions as the receptor for glial cell line derived neurotrophic factor (GDNF). The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the Ret tyrosine kinase in GDNF signaling pathway. Mice lacking the encoded protein exhibit deficits in the kidneys, the enteric nervous system, and spinal motor and sensory neurons similar mice deficient in GDNF or Ret. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35246;O35252", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005030 neurotrophin receptor activity;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71KT5-1", "uniprot_id": "ERG24_MOUSE", "mass": 46521.0, "length": 418, "protein_name": "Delta(14)-sterol reductase TM7SF2", "gene_name": "Tm7sf2", "organism": "Mouse", "refseq_name": "delta(14)-sterol reductase TM7SF2", "refseq_ac": "NP_082730", "gene_names_uniprotkb": "Tm7sf2", "gene_names_refseq": "3110041O18Rik; ANG1; C14SR; Dhcr14; Tm7sf2", "protein_names_uniprotkb": "Delta(14)-sterol reductase TM7SF2; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta-14-SR; Sterol C14-reductase; Transmembrane 7 superfamily member 2", "protein_names_refseq": "3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; delta(14)-sterol reductase TM7SF2; delta-14-SR; sterol C14-reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:73166); (R-MMU-6807047); (R-MMU-6807062)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18785926;21750661;23935851;33121932;34428180", "class_list": "", "function": "Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice, whereas genes involved in xenobiotic metabolism are upregulated., [RefSeq, PubMed]; These results show a significant increase in renal TNFalpha expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice. Publication Status: Online-Only, [RefSeq, PubMed]; Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5LBK0", "ec_number_list": "1.3.1.21;3.3.2.11;1.3.1.70", "go_molecular_function": "GO:0050661 NADP binding;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0033490 cholesterol biosynthetic process via lathosterol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q71KT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHG3-1", "uniprot_id": "GCC2_MOUSE", "mass": 194558.0, "length": 1680, "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "Gcc2", "organism": "Mouse", "refseq_name": "GRIP and coiled-coil domain-containing protein 2", "refseq_ac": "NP_081651", "gene_names_uniprotkb": "Gcc2; Kiaa0336", "gene_names_refseq": "0610043A03Rik; 2210420P05Rik; 2600014C01Rik; Gcc2; mKIAA0336", "protein_names_uniprotkb": "GRIP and coiled-coil domain-containing protein 2; 185 kDa Golgi coiled-coil protein; GCC185", "protein_names_refseq": "185 kDa Golgi coiled-coil protein; GCC185; GRIP and coiled-coil domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:70297); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;30779550", "class_list": "", "function": "Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSU7;Q8BR44;Q8R2Q5;Q9CT45", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0005737 cytoplasm", "go_biological_process": "GO:0006622 protein targeting to lysosome;GO:0042147 retrograde transport, endosome to Golgi;GO:0090161 Golgi ribbon formation;GO:0034067 protein localization to Golgi apparatus;GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CHG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXP9-1", "uniprot_id": "EXO5_MOUSE", "mass": 41624.0, "length": 373, "protein_name": "Exonuclease V", "gene_name": "Exo5", "organism": "Mouse", "refseq_name": "exonuclease V", "refseq_ac": "NP_001153515", "gene_names_uniprotkb": "Exo5; Dem1", "gene_names_refseq": "3110037I16Rik; Dem1; Exo V; Exo5; mExo5", "protein_names_uniprotkb": "Exonuclease V; 3.1.-.-; Defects in morphology protein 1 homolog; Exo V; mExo5", "protein_names_refseq": "defects in morphology 1 homolog; defects in morphology protein 1 homolog; exonuclease V; probable exonuclease V", "tax_id": 10090, "disease": "", "pathway": " (mmu:73172)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23095756", "class_list": "", "function": "Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A767;A2A769", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06194-1", "uniprot_id": "FA8_MOUSE", "mass": 266196.0, "length": 2319, "protein_name": "Coagulation factor VIII", "gene_name": "F8", "organism": "Mouse", "refseq_name": "coagulation factor VIII isoform 1 precursor", "refseq_ac": "NP_032003", "gene_names_uniprotkb": "F8; Cf8; F8c", "gene_names_refseq": "Cf-8; Cf8; F8; FVIII", "protein_names_uniprotkb": "Coagulation factor VIII; Procoagulant component", "protein_names_refseq": "Factor VIII; coagulation factor VIII isoform 1 precursor; procoagulant component", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); factor VIII deficiency (Disease Ontology:DOID:12134); hemarthrosis (Disease Ontology:DOID:801); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14069); (R-MMU-114608); (R-MMU-163841); (R-MMU-204005); (R-MMU-5694530); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "21750661;31219806;34418053;8314577", "class_list": "", "function": "Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa., [UniProtKB]", "predicted_glycosites": 26, "predicted_n_glycosites": 26, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 28, "binding_glycan_count": 0, "secondary_ac_list": "A2AN88", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007597 blood coagulation, intrinsic pathway;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q06194-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZM3-1", "uniprot_id": "ETKMT_MOUSE", "mass": 28639.0, "length": 255, "protein_name": "Electron transfer flavoprotein beta subunit lysine methyltransferase", "gene_name": "Etfbkmt", "organism": "Mouse", "refseq_name": "electron transfer flavoprotein beta subunit lysine methyltransferase isoform a", "refseq_ac": "NP_001239023", "gene_names_uniprotkb": "Etfbkmt; 4833442J19Rik; Mettl20", "gene_names_refseq": "4833442J19Rik; ETFB-KMT; Etfbkmt; Mettl20", "protein_names_uniprotkb": "Electron transfer flavoprotein beta subunit lysine methyltransferase; 2.1.1.-; ETFB lysine methyltransferase; ETFB-KMT; Protein N-lysine methyltransferase METTL20", "protein_names_refseq": "ETFB lysine methyltransferase; electron transfer flavoprotein beta subunit lysine methyltransferase isoform a; methyltransferase like 20; methyltransferase-like protein 20; protein N-lysine methyltransferase METTL20", "tax_id": 10090, "disease": "", "pathway": " (mmu:320204); (R-MMU-8876725)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25023281;29352221;34428180", "class_list": "", "function": "Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases., [UniProtKB, PubMed]; These results further indicate that METTL20-mediated protein methylation is not essential in humans but more likely modulates energy production during fasting or under other metabolic conditions where beta-oxidation is up-regulated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JKU7;Q3V219;Q8VEL3", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904736 negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0018023 peptidyl-lysine trimethylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPX5-1", "uniprot_id": "PLAT5_MOUSE", "mass": 29866.0, "length": 270, "protein_name": "Phospholipase A and acyltransferase 5", "gene_name": "Plaat5", "organism": "Mouse", "refseq_name": "phospholipase A and acyltransferase 5 isoform 1", "refseq_ac": "NP_080007", "gene_names_uniprotkb": "Plaat5; Hrasls5; Hrlp5", "gene_names_refseq": "1700055A14Rik; 1700086E08Rik; 4921526K24Rik; HRSL5; Hrasls5; Plaat5; iNAT", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 5; 2.3.1.-; 3.1.1.32; 3.1.1.4; Ca(2+)-independent N-acyltransferase; H-rev107-like protein 5; HRAS-like suppressor 5; HRSL5; iNAT", "protein_names_refseq": "Ca(2+)-independent N-acyltransferase; Ca-independent N-acyltransferase; H-rev107-like protein 5; HRAS-like suppressor 5; HRAS-like suppressor family, member 5; phospholipase A and acyltransferase 5 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66727); (R-MMU-1482839)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19000777;21750661", "class_list": "", "function": "Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8Y6;Q9CVQ2;Q9CVS0", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;3.1.1.32;3.1.1.34;3.1.1.3;3.1.2.2;2.3.1.-;3.1.1.111;3.1.1.118;3.1.1.-;2.3.1.51", "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity;GO:0016787 hydrolase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070292 N-acylphosphatidylethanolamine metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CPX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26928-1", "uniprot_id": "HGFL_MOUSE", "mass": 80619.0, "length": 716, "protein_name": "Hepatocyte growth factor-like protein", "gene_name": "Mst1", "organism": "Mouse", "refseq_name": "hepatocyte growth factor-like protein precursor", "refseq_ac": "NP_032269", "gene_names_uniprotkb": "Mst1; Hgfl", "gene_names_refseq": "D3F15S2h; D9H3F15S2; DNF15S2h; Hgfl; Mst1", "protein_names_uniprotkb": "Hepatocyte growth factor-like protein; MSP; Macrophage stimulatory protein", "protein_names_refseq": "MSP; hepatocyte growth factor-like protein precursor; hepatocyte growth factor-like protein; macrophage stimulatory protein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:15235); (R-MMU-8852405)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1832957;21750661;38898027;39253972", "class_list": "", "function": "Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTL1", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030971 receptor tyrosine kinase binding;GO:0035173 histone kinase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005773 vacuole;GO:0005576 extracellular region", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X78-1", "uniprot_id": "ERLN1_MOUSE", "mass": 39182.0, "length": 348, "protein_name": "Erlin-1", "gene_name": "Erlin1", "organism": "Mouse", "refseq_name": "erlin-1", "refseq_ac": "NP_001157831", "gene_names_uniprotkb": "Erlin1; Keo4; Spfh1", "gene_names_refseq": "2810439N09Rik; Erlin1; Keo4; Spfh1", "protein_names_uniprotkb": "Erlin-1; Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04 homolog; SPFH domain-containing protein 1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1", "protein_names_refseq": "SPFH domain family, member 1; SPFH domain-containing protein 1; endoplasmic reticulum lipid raft-associated protein 1; erlin-1; protein KE04 homolog; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 62 (Disease Ontology:DOID:0110813); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:226144); (R-MMU-382556); (R-MMU-9931269)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21610068;21750661;22020079;30135210;30899004;31219806;33300544", "class_list": "", "function": "2 MDa erlin1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic residues., [RefSeq, PubMed]; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity)., [UniProtKB, UniProtKB]; Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The erlin2 threonine to isoleucine 65 substitution inhibits erlin1/erlin2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J1G5;Q3UKI9;Q8CIH7", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0036503 ERAD pathway;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91X78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R316-1", "uniprot_id": "HBP1_MOUSE", "mass": 57645.0, "length": 516, "protein_name": "HMG box-containing protein 1", "gene_name": "Hbp1", "organism": "Mouse", "refseq_name": "HMG box-containing protein 1 isoform 1", "refseq_ac": "NP_694878", "gene_names_uniprotkb": "Hbp1", "gene_names_refseq": "1700058O05Rik; C330012F01Rik; Hbp1", "protein_names_uniprotkb": "HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1", "protein_names_refseq": "HMG box transcription factor 1; HMG box-containing protein 1 isoform 1; HMG box-containing protein 1", "tax_id": 10090, "disease": "osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:73389)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14872137;15235594;21750661;31219806;34428180;35848933;36326689;36852467;38924383;9178770", "class_list": "", "function": "HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene., [RefSeq, PubMed]; MicroRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1., [RefSeq, PubMed]; Overexpression of macrophage migration inhibitory factor protects against pressure overload-induced cardiac hypertrophy through regulating the miR-29b-3p/HBP1 axis., [RefSeq, PubMed]; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0I4;Q8BUS3;Q8C199", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043268 positive regulation of potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09602-1", "uniprot_id": "HMGN2_MOUSE", "mass": 9423.0, "length": 90, "protein_name": "Non-histone chromosomal protein HMG-17", "gene_name": "Hmgn2", "organism": "Mouse", "refseq_name": "non-histone chromosomal protein HMG-17", "refseq_ac": "NP_058653", "gene_names_uniprotkb": "Hmgn2; Hmg-17; Hmg17", "gene_names_refseq": "HMG-17; Hmg17; Hmgn2", "protein_names_uniprotkb": "Non-histone chromosomal protein HMG-17; High mobility group nucleosome-binding domain-containing protein 2", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 2; high mobility group protein 17; non-histone chromosomal protein HMG-17", "tax_id": 10090, "disease": "Axenfeld-Rieger syndrome type 1 (Disease Ontology:DOID:0110120)", "pathway": " (mmu:15331)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23806337;26495903;31219806;3194220;3342876;34428180;37828378;37950483", "class_list": "", "function": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P09602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWU3-1", "uniprot_id": "F131A_MOUSE", "mass": 39033.0, "length": 361, "protein_name": "Protein FAM131A", "gene_name": "Fam131a", "organism": "Mouse", "refseq_name": "protein FAM131A", "refseq_ac": "NP_598539", "gene_names_uniprotkb": "Fam131a", "gene_names_refseq": "2900046G09Rik; Fam131a", "protein_names_uniprotkb": "Protein FAM131A", "protein_names_refseq": "protein FAM131A", "tax_id": 10090, "disease": "", "pathway": " (mmu:78408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KY5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BWU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6U8-1", "uniprot_id": "F162A_MOUSE", "mass": 17725.0, "length": 155, "protein_name": "Protein FAM162A", "gene_name": "Fam162a", "organism": "Mouse", "refseq_name": "protein FAM162A", "refseq_ac": "NP_081618", "gene_names_uniprotkb": "Fam162a; E2ig5", "gene_names_refseq": "2310056P07Rik; Fam162a; HGTD-P", "protein_names_uniprotkb": "Protein FAM162A; E2-induced gene 5 protein homolog; Growth and transformation-dependent protein; HGTD-P", "protein_names_refseq": "E2-induced gene 5 protein homolog; growth and transformation-dependent protein; protein FAM162A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70186)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15082785;17316997;21750661;28528544;30059200;36288343;37507081", "class_list": "", "function": "Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0071456 cellular response to hypoxia;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D6U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3LHH8-1", "uniprot_id": "ESP1_MOUSE", "mass": 11346.0, "length": 102, "protein_name": "Exocrine gland-secreted peptide 1", "gene_name": "Esp1", "organism": "Mouse", "refseq_name": "exocrine gland-secreted peptide 1 precursor", "refseq_ac": "NP_001033589", "gene_names_uniprotkb": "Esp1; Gm6084", "gene_names_refseq": "EG619517; Esp1; Gm6084", "protein_names_uniprotkb": "Exocrine gland-secreted peptide 1", "protein_names_refseq": "exocrine gland-secreted peptide 1 precursor; exocrine gland-secreting peptide 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:619517)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16208374;17935991;20596023;21750661;23576433;29033330;40885482", "class_list": "", "function": "Charge-charge interactions determine the specificity of ESP1 binding to V2Rp5 in the large extracellular region characteristic of class C GPCRs., [RefSeq, PubMed]; ESP1 is a crucial male pheromone that regulates female reproductive behaviour through a specific receptor in the mouse vomeronasal system., [RefSeq, PubMed]; Identification of a male-specific 7-kDa peptide secreted from the extraorbital lacrimal gland; ESP1 is secreted from the eyes and is transferred to the female vomeronasal organ, where it stimulates pheromone receptor-expressing vomeronasal sensory neurons, [RefSeq, PubMed]; Male-specific phermone which is recognized by the Vmn2r116/V2rp5 receptor in the vomeronasal organ (VNO) and enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The male pheromone exocrine gland-secreting peptide 1 (ESP1) is one of the key factors that causes pregnancy block. Female mice exhibited high pregnancy failure rates upon encountering males that secreted different levels of ESP1 compared to the mated male., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005186 pheromone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045925 positive regulation of female receptivity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3LHH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBG5-1", "uniprot_id": "PLIN3_MOUSE", "mass": 47262.0, "length": 437, "protein_name": "Perilipin-3", "gene_name": "Plin3", "organism": "Mouse", "refseq_name": "perilipin-3", "refseq_ac": "NP_080112", "gene_names_uniprotkb": "Plin3; M6prbp1; Tip47", "gene_names_refseq": "1300012C15Rik; M6prbp1; Plin3; Tip47", "protein_names_uniprotkb": "Perilipin-3; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1", "protein_names_refseq": "cargo selection protein TIP47; mannose-6-phosphate receptor binding protein 1; perilipin-3", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:66905); (R-MMU-6811440); (R-MMU-9706019)", "pathway_count": 3, "publication_count": 30, "publication_id_list": "10.3389/fragi.2021.757801;15242596;15731108;17322886;21750661;22517741;22645316;23443134;23806337;25153642;27941027;28011936;28135057;28528544;29440067;30059200;31119787;31219806;32782141;32848054;34428180;34678516;35820727;35822049;36084651;36107452;36852467;37507081;40021952;40885482", "class_list": "", "function": "Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice., [RefSeq, PubMed]; Our studies demonstrate that the lipid droplets (LDs) scaffold protein, PLIN3, is essential for HCV core-induced hepatic steatosis and provide new insights into the pathogenesis of HCV., [RefSeq, PubMed]; Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum., [RefSeq, PubMed]; Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network., [UniProtKB, UniProtKB]; The non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess, [RefSeq, PubMed]; These data suggest that Plin3 acts as an intrinsic protective factor preventing futile beige adipocyte formation by limiting lipid metabolism and thermogenic gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK05;Q8BKV9;Q9CZK1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:1905691 lipid droplet disassembly", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q9DBG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDK3-1", "uniprot_id": "ELF5_MOUSE", "mass": 29873.0, "length": 253, "protein_name": "ETS-related transcription factor Elf-5", "gene_name": "Elf5", "organism": "Mouse", "refseq_name": "ETS-related transcription factor Elf-5", "refseq_ac": "NP_001139285", "gene_names_uniprotkb": "Elf5", "gene_names_refseq": "ESE-2; ESE-5.; ESE-5; Elf5", "protein_names_uniprotkb": "ETS-related transcription factor Elf-5; E74-like factor 5", "protein_names_refseq": "ETS-related transcription factor Elf-5; Epithelium specific Ets-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:13711)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15650748;15655699;15829518;16229011;16704374;21750661;9840936", "class_list": "", "function": "Demonstrated for the first time that Elf5 protein is localised to epithelium of exocrine glands including the kidney, mammary gland, stomach and the submandibular salivary gland, [RefSeq, PubMed]; Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy, [RefSeq, PubMed]; KRF is a novel transcription factor that is restricted to nuclear extracts isolated from keratinocytes and that binds to unique DNA sequences, which do not resemble any known consensus binding motif for transcription factors.[KRF], [RefSeq, PubMed]; Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning., [RefSeq, PubMed]; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921H5;Q9Z2K6", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007398 ectoderm development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VDK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESS0-1", "uniprot_id": "DUS10_MOUSE", "mass": 52532.0, "length": 483, "protein_name": "Dual specificity protein phosphatase 10", "gene_name": "Dusp10", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 10", "refseq_ac": "NP_071302", "gene_names_uniprotkb": "Dusp10; Mkp5", "gene_names_refseq": "2610306G15Rik; Dusp10; MKP-5; MKP5", "protein_names_uniprotkb": "Dual specificity protein phosphatase 10; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 5; MKP-5; Mitogen-activated protein kinase phosphatase 5", "protein_names_refseq": "MAP kinase phosphatase 5; dual specificity protein phosphatase 10; mitogen-activated protein kinase phosphatase 5", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (mmu:63953); (R-MMU-112409); (R-MMU-5675221)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11060451;15306813;21750661;34782469;34992607;37164190;37429895", "class_list": "", "function": "DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway., [RefSeq, PubMed]; De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes., [RefSeq, PubMed]; MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases, [RefSeq, PubMed]; Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3L3;Q9CZY9", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0016311 dephosphorylation;GO:0032496 response to lipopolysaccharide;GO:0050680 negative regulation of epithelial cell proliferation;GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYI4-1", "uniprot_id": "DJB12_MOUSE", "mass": 41988.0, "length": 376, "protein_name": "DnaJ homolog subfamily B member 12", "gene_name": "Dnajb12", "organism": "Mouse", "refseq_name": "dnaJ homolog subfamily B member 12 isoform 2", "refseq_ac": "NP_064349", "gene_names_uniprotkb": "Dnajb12", "gene_names_refseq": "Dj10; Dnajb12; mDj10", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 12; mDj10", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 12; DnaJ homolog 10; dnaJ homolog subfamily B member 12 isoform 2; dnaJ homolog subfamily B member 12", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:56709)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11147971;21750661", "class_list": "", "function": "Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K037", "ec_number_list": "", "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0036503 ERAD pathway;GO:0071218 cellular response to misfolded protein;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z324-1", "uniprot_id": "DPM2_MOUSE", "mass": 9376.0, "length": 84, "protein_name": "Dolichol phosphate-mannose biosynthesis regulatory protein", "gene_name": "Dpm2", "organism": "Mouse", "refseq_name": "dolichol phosphate-mannose biosynthesis regulatory protein", "refseq_ac": "NP_034203", "gene_names_uniprotkb": "Dpm2", "gene_names_refseq": "Dpm2", "protein_names_uniprotkb": "Dolichol phosphate-mannose biosynthesis regulatory protein; DPM synthase subunit 2; Dolichol-phosphate mannose synthase subunit 2", "protein_names_refseq": "DPM synthase subunit 2; dolichol phosphate-mannose biosynthesis regulatory protein; dolichol-phosphate (beta-D) mannosyltransferase 2; dolichol-phosphate mannose synthase subunit 2", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Iu (Disease Ontology:DOID:0080571)", "pathway": " (mmu:13481); (R-MMU-162699); (R-MMU-162710)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;9724629", "class_list": "glycogene", "function": "Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0008047 enzyme activator activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006506 GPI anchor biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D113-1", "uniprot_id": "DNLZ_MOUSE", "mass": 19403.0, "length": 177, "protein_name": "DNL-type zinc finger protein", "gene_name": "Dnlz", "organism": "Mouse", "refseq_name": "DNL-type zinc finger protein isoform 2", "refseq_ac": "NP_001132975", "gene_names_uniprotkb": "Dnlz; D2Bwg1335e", "gene_names_refseq": "1110034G11Rik; D2Bwg1335e; Dnlz; HEP1", "protein_names_uniprotkb": "DNL-type zinc finger protein; HEP1; Hsp70-escort protein 1; mtHsp70-escort protein", "protein_names_refseq": "DNL-type zinc finger protein isoform 2; DNL-type zinc finger protein; hsp70-escort protein 1; mtHsp70-escort protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:52838)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTG5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1Q4-1", "uniprot_id": "DPM3_MOUSE", "mass": 10139.0, "length": 92, "protein_name": "Dolichol-phosphate mannosyltransferase subunit 3", "gene_name": "Dpm3", "organism": "Mouse", "refseq_name": "dolichol-phosphate mannosyltransferase subunit 3", "refseq_ac": "NP_081043", "gene_names_uniprotkb": "Dpm3", "gene_names_refseq": "1110001H19Rik; Dpm3", "protein_names_uniprotkb": "Dolichol-phosphate mannosyltransferase subunit 3; DPM synthase subunit 3; Dolichol-phosphate mannose synthase subunit 3; Dolichyl-phosphate beta-D-mannosyltransferase subunit 3; MPD synthase subunit 3; Mannose-P-dolichol synthase subunit 3", "protein_names_refseq": "DPM synthase complex subunit 3; DPM synthase subunit 3; MPD synthase subunit 3; dolichol-phosphate mannose synthase subunit 3; dolichol-phosphate mannosyltransferase subunit 3; dolichyl-phosphate beta-D-mannosyltransferase subunit 3; mannose-P-dolichol synthase subunit 3", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); muscular dystrophy-dystroglycanopathy type B15 (Disease Ontology:DOID:0112376)", "pathway": " (mmu:68563); (R-MMU-162699)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30084848", "class_list": "glycogene", "function": "Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D1Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D700-1", "uniprot_id": "DUS26_MOUSE", "mass": 23946.0, "length": 211, "protein_name": "Dual specificity protein phosphatase 26", "gene_name": "Dusp26", "organism": "Mouse", "refseq_name": "dual specificity protein phosphatase 26", "refseq_ac": "NP_080145", "gene_names_uniprotkb": "Dusp26; Skrp3", "gene_names_refseq": "2310043K02Rik; Dusp26; Skrp3", "protein_names_uniprotkb": "Dual specificity protein phosphatase 26; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase SKRP3", "protein_names_refseq": "dual specificity phosphatase 26 (putative); dual specificity protein phosphatase 26; dual-specificity phosphatase SKRP3", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:66959)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16581800;17001450;24548998;26247726;30582764;31599954;31700183", "class_list": "", "function": "DUSP26 down-regulation is an effective antineoplastic neuroblastoma strategy through activation of the p53 and p38 MAPK tumor-suppressor pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Expression decreased in the liver tissue of mice with hepatic steatosis and genetically obese mice, [RefSeq, PubMed]; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity., [UniProtKB]; Results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth., [RefSeq, PubMed]; These data suggest that adipsin/C3a and DUSP26-directed therapies may represent a novel approach to achieve beta cell health to treat and prevent type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCZ5", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.5;3.1.3.21;3.1.3.18;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0002039 p53 binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045785 positive regulation of cell adhesion;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8U7-1", "uniprot_id": "DTWD1_MOUSE", "mass": 34734.0, "length": 304, "protein_name": "tRNA-uridine aminocarboxypropyltransferase 1", "gene_name": "Dtwd1", "organism": "Mouse", "refseq_name": "tRNA-uridine aminocarboxypropyltransferase 1", "refseq_ac": "NP_081257", "gene_names_uniprotkb": "Dtwd1", "gene_names_refseq": "1810033A06Rik; Dtwd1", "protein_names_uniprotkb": "tRNA-uridine aminocarboxypropyltransferase 1; 2.5.1.25; DTW domain-containing protein 1", "protein_names_refseq": "DTW domain-containing protein 1; tRNA-uridine aminocarboxypropyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69185)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20))., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.25", "go_molecular_function": "GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D8U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9R7-1", "uniprot_id": "DMRTC_MOUSE", "mass": 19230.0, "length": 182, "protein_name": "Doublesex- and mab-3-related transcription factor C1", "gene_name": "Dmrtc1a; Dmrtc1", "organism": "Mouse", "refseq_name": "doublesex- and mab-3-related transcription factor C1 isoform c", "refseq_ac": "NP_001033705", "gene_names_uniprotkb": "Dmrtc1a; Dmrtc1; Dmrt8.1; Dmrtc1a", "gene_names_refseq": "1700030H14Rik; 4921520P21Rik; DMRTC1; Dmrt8.1; Dmrtc1a", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor C1; Doublesex- and mab-3-related transcription factor 8.1", "protein_names_refseq": "doublesex and mab-3 related transcription factor 8.1; doublesex- and mab-3-related transcription factor C1 isoform c; doublesex- and mab-3-related transcription factor C1; likely ortologue to human doublesex-and mab-3-related transcription factor C1 (Dmrtc1)", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:70887)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16488114;21183079;21750661", "class_list": "", "function": "Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AX31;B1AX32;Q2PMY0;Q9D5U3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAJ5-1", "uniprot_id": "DLRB2_MOUSE", "mass": 10876.0, "length": 96, "protein_name": "Dynein light chain roadblock-type 2", "gene_name": "Dynlrb2", "organism": "Mouse", "refseq_name": "dynein light chain roadblock-type 2", "refseq_ac": "NP_083573", "gene_names_uniprotkb": "Dynlrb2; Dncl2b; Dnlc2b", "gene_names_refseq": "1700009A04Rik; DNLC2B; Dncl2b; Dynlrb2", "protein_names_uniprotkb": "Dynein light chain roadblock-type 2; Dynein light chain 2B, cytoplasmic", "protein_names_refseq": "dynein light chain 2B, cytoplasmic; dynein light chain roadblock-type 2; dynein, cytoplasmic, light chain 2B; dynein, cytoplasmic, light polypeptide 2B", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:75465); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14752807;36973253", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules., [UniProtKB]; Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC23-1", "uniprot_id": "DJC10_MOUSE", "mass": 90583.0, "length": 793, "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10", "gene_name": "Dnajc10", "organism": "Mouse", "refseq_name": "endoplasmic reticulum disulfide reductase DNAJC10 precursor", "refseq_ac": "NP_077143", "gene_names_uniprotkb": "Dnajc10; Erdj5; Jpdi", "gene_names_refseq": "1200006L06Rik; D2Ertd706e; Dnajc10; ERdj5; JPDI", "protein_names_uniprotkb": "Endoplasmic reticulum disulfide reductase DNAJC10; 1.8.4.2; DnaJ homolog subfamily C member 10; ER-resident protein ERdj5; Endoplasmic reticulum DNA J domain-containing protein 5; Endoplasmic reticulum DnaJ-PDI fusion protein 1; J domain-containing PDI-like protein; J domain-containing protein disulfide isomerase-like protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 10; ER-resident protein ERdj5; dnaJ homolog subfamily C member 10; endoplasmic reticulum DNA J domain-containing protein 5; endoplasmic reticulum DnaJ-PDI fusion protein 1; endoplasmic reticulum disulfide reductase DNAJC10 precursor; endoplasmic reticulum disulfide reductase DNAJC10; j domain-containing PDI-like protein; j domain-containing protein disulfide isomerase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66861)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12411443;12446677;18653895;19788412;21329881;21952136;22645316;26740625;34203471;34428180;35390453;36759578;37496439", "class_list": "", "function": "DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. Publication Status: Online-Only, [RefSeq, PubMed]; ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions., [RefSeq, PubMed]; Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins (PubMed:12411443, PubMed:12446677, PubMed:18653895, PubMed:21329881). Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process (By similarity). In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation (PubMed:18653895, PubMed:21329881). Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds, [RefSeq, PubMed]; Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2., [RefSeq, PubMed]; Study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASA2;Q71S84;Q8CH78;Q8CIB0;Q99LV4", "ec_number_list": "1.8.4.2", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0036503 ERAD pathway;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034976 response to endoplasmic reticulum stress;GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DC23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI44-1", "uniprot_id": "DMAP1_MOUSE", "mass": 53130.0, "length": 468, "protein_name": "DNA methyltransferase 1-associated protein 1", "gene_name": "Dmap1", "organism": "Mouse", "refseq_name": "DNA methyltransferase 1-associated protein 1", "refseq_ac": "NP_075667", "gene_names_uniprotkb": "Dmap1; Mmtr", "gene_names_refseq": "1500016M21Rik; DNMAP1; DNMTAP1; Dmap1; Dmtap1; mKIAA1425", "protein_names_uniprotkb": "DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1; MAT1-mediated transcriptional repressor", "protein_names_refseq": "DNA methyltransferase 1-associated protein 1; DNMT1 associated protein-1; MAT1-mediated transcriptional repressor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66233)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10888872;14978102;15345747;30932271;32403252", "class_list": "", "function": "In this study, two-hybrid screening leads to the identification of DNMT1 associated protein, DMAP1, as a Daax-interacting protein., [RefSeq, PubMed]; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity)., [UniProtKB, PubMed]; MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins. Publication Status: Online-Only, [RefSeq, PubMed]; The results establish Dmap1 as a modulator of cardiac reprogramming and myocytic induction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99LM0;Q9CSS9;Q9DB33", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JI44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QX60-1", "uniprot_id": "DGUOK_MOUSE", "mass": 32281.0, "length": 277, "protein_name": "Deoxyguanosine kinase, mitochondrial", "gene_name": "Dguok", "organism": "Mouse", "refseq_name": "deoxyguanosine kinase, mitochondrial isoform 1", "refseq_ac": "NP_038792", "gene_names_uniprotkb": "Dguok; Dgk", "gene_names_refseq": "Dguok; dGK1; dGK2; dGK3; dGK", "protein_names_uniprotkb": "Deoxyguanosine kinase, mitochondrial; 2.7.1.113; 2.7.1.76; Deoxyadenosine kinase, mitochondrial", "protein_names_refseq": "deoxyadenosine kinase, mitochondrial; deoxyguanosine kinase, mitochondrial isoform 1; deoxyguanosine kinase, mitochondrial", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 (Disease Ontology:DOID:0111516); portal hypertension (Disease Ontology:DOID:10762); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:27369); (R-MMU-74217)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10455141;21750661;31127938;36709400", "class_list": "", "function": "Deoxyguanosine kinase mutation F180S is associated with a lean phenotype in mice., [RefSeq, PubMed]; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:10455141). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (PubMed:10455141). Widely used as target of antiviral and chemotherapeutic agents., [UniProtKB, PubMed, UniProtKB]; We conclude that Dguok has a major role for the synthesis of deoxyribonucleotides for mtDNA replication particularly in the liver, similar to the human disorder. Our data also show a catabolic lipid metabolism in liver tissue of Dguok-/-., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBU2;Q9R0Y2;Q9WUT9", "ec_number_list": "2.7.1.113;2.7.1.76;2.7.1.74", "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0005524 ATP binding;GO:0019136 deoxynucleoside kinase activity;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046070 dGTP metabolic process;GO:0046122 purine deoxyribonucleoside metabolic process;GO:0006468 protein phosphorylation;GO:0010977 negative regulation of neuron projection development;GO:0032261 purine nucleotide salvage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QX60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXE2-1", "uniprot_id": "DPOLL_MOUSE", "mass": 62943.0, "length": 573, "protein_name": "DNA polymerase lambda", "gene_name": "Poll", "organism": "Mouse", "refseq_name": "DNA polymerase lambda isoform 1", "refseq_ac": "NP_001317435", "gene_names_uniprotkb": "Poll; Polk", "gene_names_refseq": "1110003P06Rik; Poll", "protein_names_uniprotkb": "DNA polymerase lambda; 2.7.7.7; 4.2.99.-; DNA polymerase kappa; Pol Lambda", "protein_names_refseq": "DNA polymerase lambda isoform 1; DNA polymerase lambda; pol Lambda", "tax_id": 10090, "disease": "", "pathway": " (mmu:56626); (R-MMU-5693571)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10982892;11909969;11937519;30763888;31219806;34428180;35820727", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB]; DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair, [RefSeq, PubMed]; Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome., [RefSeq, PubMed]; Pol lambda is not required for normal Ig gene hypermutation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTJ1", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;4.2.99.18;5.6.2.4;2.7.7.7;4.2.99.-;2.7.11.1;2.7.7.102;6.5.1.1;5.6.2.-;3.1.-.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006287 base-excision repair, gap-filling;GO:0006260 DNA replication;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXE2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZD8-1", "uniprot_id": "DIC_MOUSE", "mass": 31715.0, "length": 287, "protein_name": "Mitochondrial dicarboxylate carrier", "gene_name": "Slc25a10", "organism": "Mouse", "refseq_name": "mitochondrial dicarboxylate carrier", "refseq_ac": "NP_038798", "gene_names_uniprotkb": "Slc25a10; Dic", "gene_names_refseq": "Dic; Slc25a10", "protein_names_uniprotkb": "Mitochondrial dicarboxylate carrier; DIC; Solute carrier family 25 member 10", "protein_names_refseq": "adenine nucleotide translocator), member 10; dicarboxylate ion carrier; mitochondrial dicarboxylate carrier; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 10", "tax_id": 10090, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 19 (Disease Ontology:DOID:0070450)", "pathway": " (mmu:27376); (R-MMU-1614517); (R-MMU-428643)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10567211;16027120;23576753;30943427;33746082;34428180;37453647;39409161", "class_list": "", "function": "Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:33746082). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:16027120, PubMed:30943427, PubMed:33746082). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (PubMed:33746082)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import. Publication Status: Online-Only, [RefSeq, PubMed]; Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and its inhibition might effectively reduce lipid accumulation in adipose tissues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543J6;Q99LJ9;Q9D8G8", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0005310 dicarboxylic acid transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0006869 lipid transport;GO:0006094 gluconeogenesis;GO:0006817 phosphate ion transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QZD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04744-1", "uniprot_id": "EMX2_MOUSE", "mass": 28374.0, "length": 253, "protein_name": "Homeobox protein EMX2", "gene_name": "Emx2", "organism": "Mouse", "refseq_name": "homeobox protein EMX2", "refseq_ac": "NP_034262", "gene_names_uniprotkb": "Emx2; Emx-2", "gene_names_refseq": "Emx2; Pdo", "protein_names_uniprotkb": "Homeobox protein EMX2; Empty spiracles homolog 2; Empty spiracles-like protein 2", "protein_names_refseq": "empty spiracles homolog 2; empty spiracles-like protein 2; homeobox protein EMX2", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stomach cancer (Disease Ontology:DOID:10534); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:13797)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12573261;1352754;1353865;15147765;15247416;21750661;34001891", "class_list": "", "function": "Transcription factor, which in cooperation with EMX1, acts to generate the boundary between the roof and archipallium in the developing brain (PubMed:1352754). May function in combination with OTX1/2 to specify cell fates in the developing central nervous system. In the inner ear, it controls the distribution of GPR156 at hair cell boundaries, and regulates the organization of stereociliary bundles in opposite orientations across the line of polarity reversal (LPR) (PubMed:34001891)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9A6;Q80UE7", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0021987 cerebral cortex development;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70265-1", "uniprot_id": "F262_MOUSE", "mass": 59925.0, "length": 519, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2", "gene_name": "Pfkfb2", "organism": "Mouse", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform 1", "refseq_ac": "NP_032851", "gene_names_uniprotkb": "Pfkfb2", "gene_names_refseq": "4930568D07Rik; Pfkfb2", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; PFK/FBPase 2", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; PFK-2/FBPase-2 gene B; PFK/FBPase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18640); (R-MMU-9634600)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31219806;31599954;34428180;36210013;38451470;38533937;38813509;8814283", "class_list": "glycogene", "function": "Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart., [RefSeq, PubMed]; MTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells., [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEI9", "ec_number_list": "2.7.1.105;3.1.3.46", "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0032024 positive regulation of insulin secretion;GO:0006094 gluconeogenesis;GO:0009749 response to glucose;GO:0006000 fructose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70265-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55196-1", "uniprot_id": "ENAM_MOUSE", "mass": 140954.0, "length": 1274, "protein_name": "Enamelin", "gene_name": "Enam", "organism": "Mouse", "refseq_name": "enamelin precursor", "refseq_ac": "NP_059496", "gene_names_uniprotkb": "Enam", "gene_names_refseq": "Enam; abte", "protein_names_uniprotkb": "Enamelin", "protein_names_refseq": "enamelin precursor", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1B (Disease Ontology:DOID:0110052); amelogenesis imperfecta type 1C (Disease Ontology:DOID:0110056)", "pathway": " (mmu:13801); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11062988;15345747;21285247;21750661;35820561;37191055;38716742", "class_list": "", "function": "ENAM Mutations Can Cause Hypomaturation Amelogenesis Imperfecta., [RefSeq, PubMed]; Enam expression is regulated by Msx2., [RefSeq, PubMed]; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030345 structural constituent of tooth enamel", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0042475 odontogenesis of dentin-containing tooth;GO:0031214 biomineral tissue development;GO:0022604 regulation of cell morphogenesis;GO:0070175 positive regulation of enamel mineralization;GO:0097186 amelogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WL0-1", "uniprot_id": "ES8L3_MOUSE", "mass": 68216.0, "length": 600, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 3", "gene_name": "Eps8l3", "organism": "Mouse", "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 3", "refseq_ac": "NP_598628", "gene_names_uniprotkb": "Eps8l3; Eps8r3", "gene_names_refseq": "Eps8l3; Eps8r3", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8-like protein 3; EPS8-related protein 3; Epidermal growth factor receptor pathway substrate 8-related protein 3", "protein_names_refseq": "EPS8-like protein 3; EPS8-related protein 3; ESP8-like 3; epidermal growth factor receptor kinase substrate 8-like protein 3; epidermal growth factor receptor pathway substrate 8 related protein 3", "tax_id": 10090, "disease": "hypotrichosis 5 (Disease Ontology:DOID:0110702)", "pathway": " (mmu:99662)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12620401;14565974;21750661;25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ14", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0042634 regulation of hair cycle;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91WL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924X1-1", "uniprot_id": "EPGN_MOUSE", "mass": 16799.0, "length": 152, "protein_name": "Epigen", "gene_name": "Epgn", "organism": "Mouse", "refseq_name": "epigen precursor", "refseq_ac": "NP_444317", "gene_names_uniprotkb": "Epgn", "gene_names_refseq": "2310069M11Rik; Epgn; epigen", "protein_names_uniprotkb": "Epigen; EPG; Epithelial mitogen", "protein_names_refseq": "EPG; epigen precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71920); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-212718); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9009391)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "11278323;15611079;21750661;24891618", "class_list": "", "function": "Activation of the EGFR by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density., [RefSeq, PubMed]; EPG is an EGF-like growth factor and a low affinity ligand, [RefSeq, PubMed]; Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEX5", "ec_number_list": "", "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q924X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMF2-1", "uniprot_id": "ERI1_MOUSE", "mass": 39493.0, "length": 345, "protein_name": "3'-5' exoribonuclease 1", "gene_name": "Eri1", "organism": "Mouse", "refseq_name": "3'-5' exoribonuclease 1", "refseq_ac": "NP_080343", "gene_names_uniprotkb": "Eri1; 3'exo; Thex1", "gene_names_refseq": "3'hexo; 3110010F15Rik; Eri1; Thex1; eri-1", "protein_names_uniprotkb": "3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; 3.1.13.1; Eri-1 homolog; Histone mRNA 3'-exonuclease 1", "protein_names_refseq": "3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; enhanced RNAi protein 1; eri-1 homolog; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-exonuclease 1; three prime histone mRNA exonuclease 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67276); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16004606;18438418;19470752;21750661;22613798;23202588;31160785;31219806;34428180;35820727;37352860", "class_list": "", "function": "7SB ribosomal RNA can be oligoadenylated by an unknown enzyme and/or oligouridylated by TUT4/7 and subsequently processed by Dis3l2 and Eri1., [RefSeq, PubMed]; Data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure, [RefSeq, PubMed]; Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery., [RefSeq, PubMed]; Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity., [RefSeq, PubMed]; RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs (By similarity). Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA (PubMed:18438418). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. In vitro, does not have sequence specificity. In vitro, has weak DNA exonuclease activity. In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (By similarity). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860)., [UniProtKB, PubMed, UniProtKB, PubMed]; The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA98;Q3TNT0;Q80UN4;Q8BWR6;Q9CQ63", "ec_number_list": "3.1.-.-;3.1.13.-;2.7.1.78;3.1.13.1;3.1.26.-;3.6.4.13;3.4.22.-", "go_molecular_function": "GO:0071207 histone pre-mRNA stem-loop binding;GO:0008859 exoribonuclease II activity;GO:0046872 metal ion binding;GO:0008408 3'-5' exonuclease activity;GO:0019843 rRNA binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031125 rRNA 3'-end processing;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0000460 maturation of 5.8S rRNA;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TMF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91UZ4-1", "uniprot_id": "EGLN3_MOUSE", "mass": 27302.0, "length": 239, "protein_name": "Prolyl hydroxylase EGLN3", "gene_name": "Egln3", "organism": "Mouse", "refseq_name": "prolyl hydroxylase EGLN3", "refseq_ac": "NP_082409", "gene_names_uniprotkb": "Egln3", "gene_names_refseq": "2610021G09Rik; Egln3; Hif-p4h-3; Phd3; SM-20", "protein_names_uniprotkb": "Prolyl hydroxylase EGLN3; 1.14.11.-; 1.14.11.29; Egl nine homolog 3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 3; PHD3; Prolyl hydroxylase domain-containing protein 3; SM-20", "protein_names_refseq": "HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; prolyl hydroxylase EGLN3; prolyl hydroxylase domain-containing protein 3", "tax_id": 10090, "disease": "acute kidney failure (Disease Ontology:DOID:3021); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:112407); (R-MMU-1234176)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10543731;11574160;12234095;18332118;19584355;19720742;21317538;21750661;24809345;34428180;38755642", "class_list": "", "function": "Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4, GPX4 and HIF1A (PubMed:24809345). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (By similarity). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity). Also hydroxylates HIF2A (By similarity). Has a preference for the CODD site for both HIF1A and HIF2A (By similarity). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (By similarity). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity). Acts as an inhibitor of ferroptosis by mediating hydroxylation of GPX4, thereby preventing GPX4 degradation via chaperone-mediated autophagy (By similarity). GPX4 hydroxylation is promoted by PSAT1, which provides 2-oxoglutarate substrate to EGLN3 (By similarity). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia (By similarity). Also hydroxylates PKM in hypoxia, limiting glycolysis (By similarity). Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis (By similarity). In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (By similarity). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (By similarity). Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (PubMed:24809345)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCG8;Q8C8M6;Q8CCA8;Q8R5C7", "ec_number_list": "3.4.19.12;3.4.25.1;2.3.2.24;2.3.2.23;2.3.2.27;2.3.2.32;1.14.11.29;1.14.11.-", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0031543 peptidyl-proline dioxygenase activity;GO:0031545 peptidyl-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0071456 cellular response to hypoxia;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91UZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPG7-1", "uniprot_id": "TAFA2_MOUSE", "mass": 14647.0, "length": 131, "protein_name": "Chemokine-like protein TAFA-2", "gene_name": "Tafa2", "organism": "Mouse", "refseq_name": "chemokine-like protein TAFA-2 isoform 2 precursor", "refseq_ac": "NP_001239316", "gene_names_uniprotkb": "Tafa2; Fam19a2", "gene_names_refseq": "6330575M02; FAM19A2 TAFA-2; Fam19a2; Sam2; Tafa-2; Tafa2", "protein_names_uniprotkb": "Chemokine-like protein TAFA-2", "protein_names_refseq": "chemokine-like protein TAFA-2 isoform 2 precursor; chemokine-like protein TAFA-2; family with sequence similarity 19, member A2; protein FAM19A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:268354)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15028294;21750661;30137205;37944639", "class_list": "", "function": "Chemokine-like protein TAFA-2, [RefSeq, PubMed]; Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions., [UniProtKB, PubMed]; Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway., [RefSeq, PubMed]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9Q3", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TPG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMV3-1", "uniprot_id": "FAKD5_MOUSE", "mass": 86600.0, "length": 762, "protein_name": "Non-canonical pre-mRNAs endonuclease FASTKD5, mitochondrial", "gene_name": "Fastkd5", "organism": "Mouse", "refseq_name": "FAST kinase domain-containing protein 5, mitochondrial", "refseq_ac": "NP_001139556", "gene_names_uniprotkb": "Fastkd5; Kiaa1792", "gene_names_refseq": "Fastkd5; mKIAA1792", "protein_names_uniprotkb": "Non-canonical pre-mRNAs endonuclease FASTKD5, mitochondrial; 3.1.27.-; FAST kinase domain-containing protein 5, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 5, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:380601)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20869947;21750661;31219806", "class_list": "", "function": "Required for the processing of non-canonical mitochondrial pre-mRNAs within the primary mitochondrial polycistronic transcript, i.e. pre-mRNA sequences that are not flanked by tRNA (tRNA punctuation) (By similarity). Has endoribonuclease activity and processes MT-CO1, MT-CO3 and MT-CYB pre-mRNAs, generating products with 3'/2'-phosphate or a 2',3'-cyclic phosphodiester at the 3'-end (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNY5;Q5DTV0", "ec_number_list": "4.6.1.19;3.1.27.-;6.5.1.8", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006397 mRNA processing;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TMV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZV6-1", "uniprot_id": "F161A_MOUSE", "mass": 55357.0, "length": 475, "protein_name": "Protein FAM161A", "gene_name": "Fam161a", "organism": "Mouse", "refseq_name": "protein FAM161A isoform 2", "refseq_ac": "NP_082948", "gene_names_uniprotkb": "Fam161a", "gene_names_refseq": "4930430E16Rik; Fam161a", "protein_names_uniprotkb": "Protein FAM161A", "protein_names_refseq": "protein FAM161A isoform 2; protein FAM161A", "tax_id": 10090, "disease": "retinitis pigmentosa 28 (Disease Ontology:DOID:0110365)", "pathway": " (mmu:73873)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20705278;20705279;21750661;22791751;22940612;33479377", "class_list": "", "function": "A new mouse model for retinal degeneration due to Fam161a deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; FAM161A-associated RP can be considered as a novel retinal ciliopathy and that its molecular pathogenesis may be related to other ciliopathies., [RefSeq, PubMed]; Involved in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Null mutations in FAM161A are responsible for the RP28-associated autosomal-recessive retinitis pigmentosa., [RefSeq, PubMed]; These data suggest a pivotal role for FAM161A in photoreceptors and reveal that FAM161A loss-of-function mutations are a major cause of autosomal-recessive Retinitis pigmentosa., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0000235 astral microtubule;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0060271 cilium assembly;GO:0044782 cilium organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41158-1", "uniprot_id": "ELK4_MOUSE", "mass": 46826.0, "length": 430, "protein_name": "ETS domain-containing protein Elk-4", "gene_name": "Elk4", "organism": "Mouse", "refseq_name": "ETS domain-containing protein Elk-4 isoform 1", "refseq_ac": "NP_031949", "gene_names_uniprotkb": "Elk4; Sap1", "gene_names_refseq": "2310011G17Rik; A130026I01Rik; Elk4; SAP-1; Sap1", "protein_names_uniprotkb": "ETS domain-containing protein Elk-4; SAP-1; SRF accessory protein 1; Serum response factor accessory protein 1", "protein_names_refseq": "ELK4, member of ETS oncogene family; ETS domain-containing protein Elk-4 isoform 1; ETS domain-containing protein Elk-4; SRF accessory protein 1; serum response factor accessory protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:13714)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14770179;21750661;30084848;34428180;39173777;7958835", "class_list": "", "function": "ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea., [RefSeq, PubMed]; Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously (By similarity)., [UniProtKB]; SAP-1 is required for Erk-mediated transcriptional events in thymocyte development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H693", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2E9-1", "uniprot_id": "ERO1B_MOUSE", "mass": 53518.0, "length": 467, "protein_name": "ERO1-like protein beta", "gene_name": "Ero1b", "organism": "Mouse", "refseq_name": "ERO1-like protein beta isoform 2 precursor", "refseq_ac": "NP_080460", "gene_names_uniprotkb": "Ero1b; Ero1lb", "gene_names_refseq": "1300013B24Rik; 1700065B09Rik; Ero1b; Ero1lb; ero1-beta", "protein_names_uniprotkb": "ERO1-like protein beta; 1.8.3.2; ERO1-L-beta; Endoplasmic reticulum oxidoreductase beta; Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta", "protein_names_refseq": "ERO1-L-beta; ERO1-like beta; ERO1-like protein beta isoform 2 precursor; ERO1-like protein beta; endoplasmic oxidoreductase 1 beta; endoplasmic oxidoreductin-1-like protein B; endoplasmic reticulum oxidoreductase beta; endoplasmic reticulum oxidoreductin-1-like protein B; oxidoreductin-1-L-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:67475); (R-MMU-264876)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16012172;20308425;21540283;21750661;29187734;30899004;34428180", "class_list": "", "function": "An unexpectedly selective function for ERO1-beta in oxidative protein folding in insulin-producing cells that is required for glucose homeostasis in vivo. Erratum:[J Cell Biol. 2010 May 17;189(4):769], [RefSeq, PubMed]; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo., [UniProtKB, PubMed]; Several lines of evidence suggest that ERO1lbeta is involved in maintaining insulin content of pancreatic beta cells and in regulating beta cell survival during ER oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q14DN0", "ec_number_list": "5.3.4.1;1.8.3.2", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0071949 FAD binding;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0042593 glucose homeostasis;GO:0045454 cell redox homeostasis;GO:0051604 protein maturation;GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8R2E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2Y9-1", "uniprot_id": "ELOV7_MOUSE", "mass": 33479.0, "length": 281, "protein_name": "Very long chain fatty acid elongase 7", "gene_name": "Elovl7", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 7", "refseq_ac": "NP_083277", "gene_names_uniprotkb": "Elovl7", "gene_names_refseq": "9130013K24Rik; Elovl7", "protein_names_uniprotkb": "Very long chain fatty acid elongase 7; 2.3.1.199; 3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; ELOVL fatty acid elongase 7; Elongation of very long chain fatty acids protein 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl7; ELOVL FA elongase 7; ELOVL family member 7, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 7; elongation of very long chain fatty acids-like 7; very long chain 3-ketoacyl-CoA synthase 7; very long chain 3-oxoacyl-CoA synthase 7; very long chain fatty acid elongase 7", "tax_id": 10090, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (mmu:74559); (R-MMU-75876)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;29059155;33069870;34428180", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]; High Elovl7 expression is associated with progression of castration-resistant prostate cancer., [RefSeq, PubMed]; Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX38;Q8BYY8", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97805-1", "uniprot_id": "FAM3D_MOUSE", "mass": 24988.0, "length": 223, "protein_name": "Protein FAM3D", "gene_name": "Fam3d", "organism": "Mouse", "refseq_name": "protein FAM3D precursor", "refseq_ac": "NP_666162", "gene_names_uniprotkb": "Fam3d; Oit1", "gene_names_refseq": "2310076N21Rik; EF-7; Fam3d; Oit1", "protein_names_uniprotkb": "Protein FAM3D; Oncoprotein-induced protein 1; Protein EF-7", "protein_names_refseq": "oncoprotein induced transcript 1; oncoprotein-induced protein 1; protein EF-7; protein FAM3D precursor; protein FAM3D", "tax_id": 10090, "disease": "", "pathway": " (mmu:18300)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22226334;29853563;37301198;37328068;37454871;9032278", "class_list": "", "function": "FAM3D, as a dual agonist of FPR1 and FPR2, induced Mac-1-mediated neutrophil recruitment and aggravated abdominal aortic aneurysm development through FPR-related Gi protein and beta-arrestin signaling., [RefSeq, PubMed]; FAM3D: A gut secreted protein and its potential in the regulation of glucose metabolism., [RefSeq, PubMed]; Fam3D is a gut-derived protein that is expressed and secreted in a nutritional status-dependent manner, [RefSeq, PubMed]; Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation., [RefSeq, PubMed]; Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R009;Q8R1F2", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007165 signal transduction;GO:0046676 negative regulation of insulin secretion;GO:0035904 aorta development;GO:0001780 neutrophil homeostasis;GO:1990266 neutrophil migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC03-1", "uniprot_id": "EMAL3_MOUSE", "mass": 95695.0, "length": 897, "protein_name": "Echinoderm microtubule-associated protein-like 3", "gene_name": "Eml3", "organism": "Mouse", "refseq_name": "echinoderm microtubule-associated protein-like 3 isoform 1", "refseq_ac": "NP_659121", "gene_names_uniprotkb": "Eml3", "gene_names_refseq": "Emap-3; Eml3", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 3; EMAP-3", "protein_names_refseq": "echinoderm microtubule-associated protein-like 3 isoform 1", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:225898)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;17242355;21183079;21750661", "class_list": "", "function": "Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (By similarity). Required for proper alignnment of chromosomes during metaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1S1", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0007080 mitotic metaphase chromosome alignment;GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VC03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIB9-1", "uniprot_id": "ESCO2_MOUSE", "mass": 67273.0, "length": 592, "protein_name": "N-acetyltransferase ESCO2", "gene_name": "Esco2", "organism": "Mouse", "refseq_name": "N-acetyltransferase ESCO2", "refseq_ac": "NP_082315", "gene_names_uniprotkb": "Esco2", "gene_names_refseq": "2410004I17Rik; D030072L07Rik; Esco2", "protein_names_uniprotkb": "N-acetyltransferase ESCO2; 2.3.1.-; ECO1 homolog 2; Establishment of cohesion 1 homolog 2", "protein_names_refseq": "ECO1 homolog 2; N-acetyltransferase ESCO2; establishment of cohesion 1 homolog 2", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); lung adenocarcinoma (Disease Ontology:DOID:3910); Roberts syndrome (Disease Ontology:DOID:5325); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:71988); (R-MMU-2468052)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;31219806;32255174;34428180;36210013;37968576", "class_list": "", "function": "Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3., [UniProtKB, UniProtKB]; ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMT6;Q6IQX5;Q8BNG9;Q8BQF8;Q9CRI8", "ec_number_list": "2.3.1.48;2.3.1.-;2.7.11.1;2.3.1.259;2.3.1.57;2.3.1.80;4.2.1.-", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0016407 acetyltransferase activity;GO:0004468 L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0030054 cell junction;GO:0000785 chromatin", "go_biological_process": "GO:0007059 chromosome segregation;GO:0006302 double-strand break repair;GO:0006275 regulation of DNA replication;GO:0002244 hematopoietic progenitor cell differentiation;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A9G7-1", "uniprot_id": "SHL2A_MOUSE", "mass": 20106.0, "length": 189, "protein_name": "Protein shisa-like-2A", "gene_name": "Shisal2a", "organism": "Mouse", "refseq_name": "protein shisa-like-2A", "refseq_ac": "NP_001092773", "gene_names_uniprotkb": "Shisal2a; Fam159a", "gene_names_refseq": "Fam159a; Shisal2a", "protein_names_uniprotkb": "Protein shisa-like-2A", "protein_names_refseq": "family with sequence similarity 159, member A; membrane protein FAM159A; protein shisa-like-2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:545667)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A9G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AIP0-1", "uniprot_id": "CMI2B_MOUSE", "mass": 30251.0, "length": 273, "protein_name": "Ciliary microtubule inner protein 2B", "gene_name": "Cimip2b", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 2B isoform 2", "refseq_ac": "NP_001155853", "gene_names_uniprotkb": "Cimip2b; Fam166b", "gene_names_refseq": "4833436C18Rik; Cimip2b; Fam166b", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2B", "protein_names_refseq": "ciliary microtubule inner protein 2B isoform 2; family with sequence similarity 166, member B; protein FAM166B", "tax_id": 10090, "disease": "", "pathway": " (mmu:329831)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37865089", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIP2;B0R005;B0R006;Q8C6T2;Q8CDW8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AIP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H5Z3-1", "uniprot_id": "EXC6B_MOUSE", "mass": 94130.0, "length": 810, "protein_name": "Exocyst complex component 6B", "gene_name": "Exoc6b", "organism": "Mouse", "refseq_name": "exocyst complex component 6B", "refseq_ac": "NP_796051", "gene_names_uniprotkb": "Exoc6b; Sec15b; Sec15l2", "gene_names_refseq": "4930569O18Rik; Exoc6b; G430127E12Rik; Sec15b; Sec15l2; mKIAA0919", "protein_names_uniprotkb": "Exocyst complex component 6B; Exocyst complex component Sec15B; SEC15-like protein 2", "protein_names_refseq": "SEC15-like 2; SEC15-like protein 2; exocyst complex component 6B; exocyst complex component Sec15B", "tax_id": 10090, "disease": "spondyloepimetaphyseal dysplasia with joint laxity type 3 (Disease Ontology:DOID:0112200)", "pathway": " (mmu:75914)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25428506;25605945;29187734;30084848;31219806;34428180", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN15", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000145 exocyst", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0090148 membrane fission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A6H5Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8R0V4-1", "uniprot_id": "ESP22_MOUSE", "mass": 12570.0, "length": 111, "protein_name": "Exocrine gland-secreted peptide 22", "gene_name": "Esp22", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Esp22", "gene_names_refseq": "", "protein_names_uniprotkb": "Exocrine gland-secreted peptide 22", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17935991;24089208", "class_list": "", "function": "Pheromone produced by juveniles which activates a small number of vomeronasal organ sensory neurons and exhibits a powerful inhibitory effect on adult male mating behavior., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005186 pheromone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1902436 negative regulation of male mating behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8R0V4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L85-1", "uniprot_id": "ELP5_MOUSE", "mass": 33498.0, "length": 300, "protein_name": "Elongator complex protein 5", "gene_name": "Elp5", "organism": "Mouse", "refseq_name": "elongator complex protein 5 isoform 1", "refseq_ac": "NP_061210", "gene_names_uniprotkb": "Elp5; Derp6; Rai12", "gene_names_refseq": "Derp6; Elp5; Rai12", "protein_names_uniprotkb": "Elongator complex protein 5; Dermal papilla-derived protein 6 homolog; Retinoic acid-induced protein 12", "protein_names_refseq": "dermal papilla-derived protein 6 homolog; elongator complex protein 5 isoform 1; elongator complex protein 5; retinoic acid induced 12; retinoic acid-induced protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:54351)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22854966;30097576;9371513", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (PubMed:22854966)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08973;Q9CUX2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0006400 tRNA modification;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99L85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2KGE5-1", "uniprot_id": "F229A_MOUSE", "mass": 13171.0, "length": 128, "protein_name": "Protein FAM229A", "gene_name": "Fam229a", "organism": "Mouse", "refseq_name": "protein FAM229A", "refseq_ac": "NP_001078960", "gene_names_uniprotkb": "Fam229a", "gene_names_refseq": "1700125D06Rik; Fam229a", "protein_names_uniprotkb": "Protein FAM229A", "protein_names_refseq": "protein FAM229A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68233)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2KGE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYH2-1", "uniprot_id": "PXL2A_MOUSE", "mass": 24395.0, "length": 218, "protein_name": "Peroxiredoxin-like 2A", "gene_name": "Prxl2a", "organism": "Mouse", "refseq_name": "peroxiredoxin-like 2A isoform a", "refseq_ac": "NP_001303661", "gene_names_uniprotkb": "Prxl2a; 5730469M10Rik; Fam213a; Pamm", "gene_names_refseq": "5730469M10Rik; Adrx; Fam213a; Pamm; Prxl2a", "protein_names_uniprotkb": "Peroxiredoxin-like 2A; Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM; Redox-regulatory protein FAM213A", "protein_names_refseq": "Adiporedoxin; UPF0765 protein C10orf58 homolog; family with sequence similarity 213, member A; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2A isoform a; redox-regulatory protein FAM213A; redox-regulatory protein PAMM", "tax_id": 10090, "disease": "", "pathway": " (mmu:70564)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19951071;21750661;26438880", "class_list": "", "function": "Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)., [UniProtKB, UniProtKB, PubMed]; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway., [RefSeq, PubMed]; The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0045670 regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CYH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2L9-1", "uniprot_id": "F111A_MOUSE", "mass": 69949.0, "length": 613, "protein_name": "Serine protease FAM111A", "gene_name": "Fam111a", "organism": "Mouse", "refseq_name": "serine protease FAM111A isoform 2", "refseq_ac": "NP_001333474", "gene_names_uniprotkb": "Fam111a", "gene_names_refseq": "4632417K18Rik; Fam111a", "protein_names_uniprotkb": "Serine protease FAM111A; 3.4.21.-", "protein_names_refseq": "protein FAM111A; serine protease FAM111A isoform 2; serine protease FAM111A", "tax_id": 10090, "disease": "Kenny-Caffey syndrome type 2 (Disease Ontology:DOID:0080723)", "pathway": " (mmu:107373)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20173027;21750661;25428506;25605945;28315936;30084848;35715480", "class_list": "", "function": "FAM111A is dispensable for electrolyte homeostasis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9N2;Q8BLH2;Q8CI07;Q8VE75;Q9CU11", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin", "go_biological_process": "GO:0006508 proteolysis;GO:0045071 negative regulation of viral genome replication;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88947-1", "uniprot_id": "FA10_MOUSE", "mass": 54018.0, "length": 481, "protein_name": "Coagulation factor X", "gene_name": "F10", "organism": "Mouse", "refseq_name": "coagulation factor X isoform 2 preproprotein", "refseq_ac": "NP_031998", "gene_names_uniprotkb": "F10", "gene_names_refseq": "Cf10; F10; fX", "protein_names_uniprotkb": "Coagulation factor X; 3.4.21.6; Stuart factor", "protein_names_refseq": "coagulation factor X isoform 2 preproprotein; stuart factor", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); factor X deficiency (Disease Ontology:DOID:2222); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:14058); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10823271;16944957;21750661;22383955;34428180;37469515;9684791;9783672", "class_list": "", "function": "Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity)., [UniProtKB, UniProtKB]; This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O54740;Q99L32", "ec_number_list": "3.4.21.6;3.4.21.22;3.4.21.5;3.4.21.75;3.4.21.21;4.1.1.90", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:1905370 serine-type endopeptidase complex;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0032008 positive regulation of TOR signaling;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8N2-1", "uniprot_id": "DEN10_MOUSE", "mass": 40421.0, "length": 357, "protein_name": "DENN domain-containing protein 10", "gene_name": "Dennd10", "organism": "Mouse", "refseq_name": "DENN domain-containing protein 10 isoform 2", "refseq_ac": "NP_001161301", "gene_names_uniprotkb": "Dennd10; Fam45a", "gene_names_refseq": "1810055E12Rik; Dennd10; Fam45a", "protein_names_uniprotkb": "DENN domain-containing protein 10; Protein FAM45A", "protein_names_refseq": "DENN domain-containing protein 10 isoform 2; DENN domain-containing protein 10; family with sequence similarity 45, member A; protein FAM45A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67894)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL11;Q91WS5", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005770 late endosome", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0015031 protein transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D8N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8T0-1", "uniprot_id": "FAM3A_MOUSE", "mass": 25394.0, "length": 230, "protein_name": "Protein FAM3A", "gene_name": "Fam3a", "organism": "Mouse", "refseq_name": "protein FAM3A isoform 1 precursor", "refseq_ac": "NP_001300654", "gene_names_uniprotkb": "Fam3a", "gene_names_refseq": "1810037C20Rik; Fam3a", "protein_names_uniprotkb": "Protein FAM3A", "protein_names_refseq": "family with sequence similarity 3, member A; protein FAM3A isoform 1 precursor; protein FAM3A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66294)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "21750661;24806753;25428506;26939760;28515350;28562339;30084848;30996264;31219806;37014466;37660071;38875957;38937853;39182087", "class_list": "", "function": "Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; FAM3A Deficiency - Induced Mitochondrial Dysfunction Underlies Post-Infarct Mortality and Heart Failure., [RefSeq, PubMed]; FAM3A enhances the adipogenesis of preadipocytes by activating ATP-P2 receptor-Akt pathway. Under obese condition, a decrease in FAM3A expression in adipose tissues plays important roles in the development of adipose dysfunction and type 2 diabetes., [RefSeq, PubMed]; FAM3A has a protective role against cytotoxicity via regulating the CHOP-Wnt pathway in mitochondria., [RefSeq, PubMed]; FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury., [RefSeq, PubMed]; FAM3A plays crucial roles in the regulation of glucose and lipid metabolism in the liver, where it activates the PI3K-Akt signaling pathway by way of a Ca(2+) /CaM-dependent mechanism, [RefSeq, PubMed]; FAM3A protects against liver IRI by activating Akt survival pathways, repressing inflammation and attenuating oxidative stress. Moreover, the protective effects of PPARgamma agonist(s) on liver IRI are dependent on FAM3A-ATP-Akt pathway., [RefSeq, PubMed]; FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination. Publication Status: Online-Only, [RefSeq, PubMed]; PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Study identified Fam3a, a cytokine-like protein, as a major Stat3 downstream effector in muscle stem cells and demonstrated that Fam3a is required for muscle stem cell commitment and skeletal muscle development. These findings indicate that Fam3a is a Stat3-regulated secreted factor that promotes muscle stem cell oxidative metabolism and differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:1905035 negative regulation of antifungal innate immune response;GO:0007165 signal transduction;GO:0019732 antifungal humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006754 ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D8T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505K2-1", "uniprot_id": "FHI1A_MOUSE", "mass": 120219.0, "length": 1081, "protein_name": "FHF complex subunit HOOK-interacting protein 1A", "gene_name": "Fhip1a", "organism": "Mouse", "refseq_name": "FHF complex subunit HOOK-interacting protein 1A", "refseq_ac": "NP_766270", "gene_names_uniprotkb": "Fhip1a; Fam160a1", "gene_names_refseq": "9930021J17Rik; Fam160a1; Fhip1a", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 1A", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 1A; family with sequence similarity 160, member A1; protein FAM160A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:229488)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;34428180;36210013", "class_list": "", "function": "Probable component of the FTS/Hook/FHIP complex (FHF complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ23", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:1905719 protein localization to perinuclear region of cytoplasm", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q505K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P539-1", "uniprot_id": "F222B_MOUSE", "mass": 59616.0, "length": 562, "protein_name": "Protein FAM222B", "gene_name": "Fam222b", "organism": "Mouse", "refseq_name": "protein FAM222B isoform 1", "refseq_ac": "NP_663405", "gene_names_uniprotkb": "Fam222b; BC017647", "gene_names_refseq": "9630020I17Rik; Fam222b", "protein_names_uniprotkb": "Protein FAM222B", "protein_names_refseq": "protein FAM222B isoform 1; protein FAM222B; uncharacterized protein C17orf63 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:216971)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22872234;32782141", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV50;Q8VD11", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6P539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08811-1", "uniprot_id": "ERCC2_MOUSE", "mass": 86842.0, "length": 760, "protein_name": "General transcription and DNA repair factor IIH helicase subunit XPD", "gene_name": "Ercc2", "organism": "Mouse", "refseq_name": "general transcription and DNA repair factor IIH helicase subunit XPD isoform 1", "refseq_ac": "NP_031975", "gene_names_uniprotkb": "Ercc2; Xpd", "gene_names_refseq": "CXPD; Ercc-2; Ercc2; Mhdarco15; RCO015; XPD", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase subunit XPD; 5.6.2.3; CXPD; DNA 5'-3' helicase XPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; TFIIH subunit XPD; Xeroderma pigmentosum group D-complementing protein", "protein_names_refseq": "DNA 5'-3' helicase XPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; TFIIH basal transcription factor complex helicase XPD subunit; general transcription and DNA repair factor IIH helicase subunit XPD isoform 1; general transcription and DNA repair factor IIH helicase subunit XPD; xeroderma pigmentosum group D-complementing protein", "tax_id": 10090, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal recessive congenital ichthyosis (Disease Ontology:DOID:0060655); cerebrooculofacioskeletal syndrome 2 (Disease Ontology:DOID:0080912); xeroderma pigmentosum group D (Disease Ontology:DOID:0110845); photosensitive trichothiodystrophy 1 (Disease Ontology:DOID:0111873); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); acoustic neuroma (Disease Ontology:DOID:12689); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); ovary epithelial cancer (Disease Ontology:DOID:2152); photosensitive trichothiodystrophy (Disease Ontology:DOID:2960); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); skin disease (Disease Ontology:DOID:37); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:13871); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 6, "publication_id_list": "19892989;21750661;31219806;34428180;35984892;9426063", "class_list": "", "function": "ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C487;Q9DC01", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;2.7.7.6;7.6.2.1;3.4.-.-;3.6.1.5;2.4.2.-;2.4.2.30;3.4.24.-;3.6.-.-;3.1.13.-;2.7.7.48;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;6.5.1.1;3.6.4.6;2.7.7.7;3.1.11.-;1.14.11.-;2.3.2.23;3.6.5.-;2.3.2.32;2.3.1.48;3.6.1.15;3.1.4.-;2.7.11.22;2.7.11.23;2.7.11.24;5.6.2.-;7.2.2.-;7.6.2.16;3.4.19.12;3.1.3.16;2.7.11.1;3.4.21.53;2.7.7.49;2.7.4.3;2.1.1.56;5.2.1.8", "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0043249 erythrocyte maturation;GO:0048820 hair follicle maturation;GO:0001701 in utero embryonic development;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08811-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BP22-1", "uniprot_id": "CBAR1_MOUSE", "mass": 33119.0, "length": 286, "protein_name": "CBY1-interacting BAR domain-containing protein 1", "gene_name": "Cibar1", "organism": "Mouse", "refseq_name": "CBY1-interacting BAR domain-containing protein 1 isoform 2", "refseq_ac": "NP_001297672", "gene_names_uniprotkb": "Cibar1; Fam92a1; Fam92a", "gene_names_refseq": "6720467C03Rik; Cibar1; Fam92a1; Fam92a", "protein_names_uniprotkb": "CBY1-interacting BAR domain-containing protein 1", "protein_names_refseq": "CBY1-interacting BAR domain-containing protein 1 isoform 2; CBY1-interacting BAR domain-containing protein 1; family with sequence similarity 92, member A; protein FAM92A1", "tax_id": 10090, "disease": "polydactyly (Disease Ontology:DOID:1148)", "pathway": " (mmu:68099)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17557235;21750661;27528616;29459677;30395363;30404948;38197861", "class_list": "", "function": "A new nonsyndromic autosomal recessive nonsyndromic postaxial polydactyly type A ciliopathy due to a loss-of-function variant in FAM92A., [RefSeq, PubMed]; Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (PubMed:29459677). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Protein expression, expressing profile and subcellular localization of AK078438 gene set the basis for further exploration of its functions.[AK078438], [RefSeq, PubMed]; The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVA5;A2AVA6;A2AVA7;Q7TNQ9;Q8C2F8;Q8VDU6;Q9D2J3", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0097749 membrane tubulation;GO:0045880 positive regulation of smoothened signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BP22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41971-1", "uniprot_id": "ELK3_MOUSE", "mass": 44414.0, "length": 409, "protein_name": "ETS domain-containing protein Elk-3", "gene_name": "Elk3", "organism": "Mouse", "refseq_name": "ETS domain-containing protein Elk-3 isoform Elk3c", "refseq_ac": "NP_001309194", "gene_names_uniprotkb": "Elk3; Erp; Net", "gene_names_refseq": "D430049E23Rik; Elk3; Erp; Etrp; Net; Sap-2", "protein_names_uniprotkb": "ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET", "protein_names_refseq": "ELK3, member of ETS oncogene family; ETS domain-containing protein Elk-3 isoform Elk3c; ETS domain-containing protein Elk-3; ETS-domain protein ELK-3; ETS-related protein ERP; ETS-related protein NET", "tax_id": 10090, "disease": "congenital chylothorax (Disease Ontology:DOID:0060646)", "pathway": " (mmu:13713)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;30084848;31219806;35953472;37400491;38071773;7909357;7958835;8892757", "class_list": "", "function": "Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5., [RefSeq, PubMed]; May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element., [UniProtKB]; The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97747;Q62346;Q8BWH1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41971-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49749-1", "uniprot_id": "EVX2_MOUSE", "mass": 47902.0, "length": 475, "protein_name": "Homeobox even-skipped homolog protein 2", "gene_name": "Evx2", "organism": "Mouse", "refseq_name": "homeobox even-skipped homolog protein 2", "refseq_ac": "NP_031993", "gene_names_uniprotkb": "Evx2; Evx-2", "gene_names_refseq": "Evx-2; Evx2", "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 2; EVX-2", "protein_names_refseq": "even skipped homeotic gene 2 homolog; homeobox even-skipped homolog protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14029)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1349539;21750661", "class_list": "", "function": "This gene is located at the 5' end of the Hoxd gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. The encoded protein plays a role in limb morphogenesis. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VU0-1", "uniprot_id": "FAM3C_MOUSE", "mass": 24753.0, "length": 227, "protein_name": "Protein FAM3C", "gene_name": "Fam3c", "organism": "Mouse", "refseq_name": "protein FAM3C precursor", "refseq_ac": "NP_613053", "gene_names_uniprotkb": "Fam3c; D6Wsu176e; Ilei", "gene_names_refseq": "D6Wsu176e; Fam3c; Ilei", "protein_names_uniprotkb": "Protein FAM3C; Interleukin-like EMT inducer", "protein_names_refseq": "family with sequence similarity 3, member C; interleukin-like EMT inducer; protein FAM3C precursor; protein FAM3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:27999); (R-MMU-114608)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15194199;16959614;17322886;19015638;20059962;20154680;21750661;28751379;29871931;34428180;36632230;37226685;37828378", "class_list": "", "function": "Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness., [RefSeq, PubMed]; FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites. Publication Status: Online-Only, [RefSeq, PubMed]; FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis, [RefSeq, PubMed]; FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice., [RefSeq, PubMed]; ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1., [RefSeq, PubMed]; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YY7;Q7TML1;Q9CTB4", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0030223 neutrophil differentiation;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91VU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W54-1", "uniprot_id": "FACE1_MOUSE", "mass": 54735.0, "length": 475, "protein_name": "CAAX prenyl protease 1 homolog", "gene_name": "Zmpste24", "organism": "Mouse", "refseq_name": "CAAX prenyl protease 1 homolog", "refseq_ac": "NP_766288", "gene_names_uniprotkb": "Zmpste24; Face1", "gene_names_refseq": "A530043O15Rik; D030046F19; FACE1; Face-1; MADB; STE24; Ste24p; Zmpste24", "protein_names_uniprotkb": "CAAX prenyl protease 1 homolog; 3.4.24.84; FACE-1; Farnesylated proteins-converting enzyme 1; Prenyl protein-specific endoprotease 1; Zinc metalloproteinase Ste24 homolog", "protein_names_refseq": "CAAX prenyl protease 1 homolog; farnesylated-proteins converting enzyme 1; prenyl protein-specific endoprotease 1; zinc metallopeptidase, STE24 homolog; zinc metalloproteinase, STE24 homolog", "tax_id": 10090, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); restrictive dermopathy (Disease Ontology:DOID:0060762); restrictive dermopathy 1 (Disease Ontology:DOID:0070369); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); mandibuloacral dysplasia type B lipodystrophy (Disease Ontology:DOID:0081129); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); progeria (Disease Ontology:DOID:3911); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:230709)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11399759;11923874;12235369;15608054;17652517;21750661;27462105;28246125;30084848;34428180;37217512", "class_list": "", "function": "Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice., [RefSeq, PubMed]; The progeria-like phenotypes caused by the lack of Zmpste24 in knockout mice is eliminated by heterozygosity for Lmna, [RefSeq, PubMed]; Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:11923874, PubMed:12235369, PubMed:17652517, PubMed:27462105). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:11399759, PubMed:17652517). Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses (PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:28246125)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Zmpste24 has a role in processing of prelamin A and lack of Zmpste24 results in a brittle bone phenotype, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJK4;Q8K569", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:1903799 negative regulation of miRNA processing;GO:0060993 kidney morphogenesis;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0003231 cardiac ventricle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80W54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55026-1", "uniprot_id": "ENTP2_MOUSE", "mass": 54319.0, "length": 495, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 2", "gene_name": "Entpd2", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 2", "refseq_ac": "NP_033979", "gene_names_uniprotkb": "Entpd2; Cd39l1", "gene_names_refseq": "Cd39l1; Entpd2; NTPDase2", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 2; 3.6.1.5; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2; NTPDase 2", "protein_names_refseq": "CD39 antigen-like 1; NTPDase 2; ecto-ATP diphosphohydrolase 2; ecto-ATPDase 2; ecto-ATPase 2; ectonucleoside triphosphate diphosphohydrolase 2", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (mmu:12496); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11929769;18404504;19349973;30899004;33300544;9271669;9624117", "class_list": "", "function": "Catalytic properties and vascular topography have implications for thromboregulation, [RefSeq, PubMed]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:18404504, PubMed:9624117). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:18404504, PubMed:9624117). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:18404504, PubMed:9624117). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:18404504, PubMed:9624117). All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35928;Q9DCR9", "ec_number_list": "3.6.5.-;3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.6.5.2;3.6.1.62;3.6.1.64;3.1.13.1;5.6.2.6;3.6.5.3;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;3.6.5.4;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.5.5;3.6.4.6;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;3.6.1.6;2.7.11.1;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.1.16;3.6.1.53;3.6.1.42", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044297 cell body;GO:0005604 basement membrane;GO:0031253 cell projection membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030168 platelet activation;GO:0009203 ribonucleoside triphosphate catabolic process;GO:0071354 cellular response to interleukin-6;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "O55026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07321-1", "uniprot_id": "EPO_MOUSE", "mass": 21365.0, "length": 192, "protein_name": "Erythropoietin", "gene_name": "Epo", "organism": "Mouse", "refseq_name": "erythropoietin isoform 1 precursor", "refseq_ac": "NP_031968", "gene_names_uniprotkb": "Epo", "gene_names_refseq": "Epo", "protein_names_uniprotkb": "Erythropoietin", "protein_names_refseq": "erythropoietin isoform 1 precursor", "tax_id": 10090, "disease": "limb ischemia (Disease Ontology:DOID:0050852); familial erythrocytosis 5 (Disease Ontology:DOID:0080290); Alzheimer's disease (Disease Ontology:DOID:10652); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); porphyria (Disease Ontology:DOID:13268); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); placental insufficiency (Disease Ontology:DOID:3891); macular retinal edema (Disease Ontology:DOID:4449); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:13856); (R-MMU-9027276); (R-MMU-9027284)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11239002;3022133;3773894;9365246", "class_list": "", "function": "Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3., [UniProtKB, UniProtKB]; This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005128 erythropoietin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0044297 cell body", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11370-1", "uniprot_id": "ENV2_MOUSE", "mass": 74453.0, "length": 679, "protein_name": "Retrovirus-related Env polyprotein from Fv-4 locus", "gene_name": "Fv4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fv4; Env", "gene_names_refseq": "", "protein_names_uniprotkb": "Retrovirus-related Env polyprotein from Fv-4 locus", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "22589728;22872234;2304138;25428506;2991595;30779550;33725478;34203471;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61529", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41164-1", "uniprot_id": "ETV1_MOUSE", "mass": 55041.0, "length": 477, "protein_name": "ETS translocation variant 1", "gene_name": "Etv1", "organism": "Mouse", "refseq_name": "ETS translocation variant 1 isoform a", "refseq_ac": "NP_031986", "gene_names_uniprotkb": "Etv1; Er81; Etsrp81", "gene_names_refseq": "ER81; Etsrp81; Etv1", "protein_names_uniprotkb": "ETS translocation variant 1; Ets-related protein 81", "protein_names_refseq": "ETS translocation variant 1 isoform a; ets variant gene 1; ets-related protein 81", "tax_id": 10090, "disease": "bipolar disorder (Disease Ontology:DOID:3312); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14009)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1340465;19287374;21750661", "class_list": "", "function": "Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:1340465). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (PubMed:19287374)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41969-1", "uniprot_id": "ELK1_MOUSE", "mass": 45271.0, "length": 429, "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "Elk1", "organism": "Mouse", "refseq_name": "ETS domain-containing protein Elk-1", "refseq_ac": "NP_031948", "gene_names_uniprotkb": "Elk1", "gene_names_refseq": "Elk-1; Elk1", "protein_names_uniprotkb": "ETS domain-containing protein Elk-1", "protein_names_refseq": "ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:13712)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11050086;35820727;36852467;38310670;7889942;7958835;8863747", "class_list": "", "function": "ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury., [RefSeq, PubMed]; Characterizes an orthologous rat short isoform derived from an in-frame downstream start codon., [RefSeq, PubMed]; This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene may produce multiple isoforms by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]., [RefSeq]; Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1M9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030425 dendrite;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49222-1", "uniprot_id": "EPB42_MOUSE", "mass": 76756.0, "length": 691, "protein_name": "Protein 4.2", "gene_name": "Epb42", "organism": "Mouse", "refseq_name": "protein 4.2", "refseq_ac": "NP_038541", "gene_names_uniprotkb": "Epb42; Epb4.2", "gene_names_refseq": "Epb4.2; Epb42", "protein_names_uniprotkb": "Protein 4.2; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; P4.2", "protein_names_refseq": "P4.2; erythrocyte protein 4.2; erythrocyte protein band 4.2; protein 4.2", "tax_id": 10090, "disease": "hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); hereditary spherocytosis type 5 (Disease Ontology:DOID:0110920); hereditary spherocytosis (Disease Ontology:DOID:12971)", "pathway": " (mmu:13828)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;25428506;7919657;7959722", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane., [UniProtKB, UniProtKB]; The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP33", "ec_number_list": "", "go_molecular_function": "GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030863 cortical cytoskeleton;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0000902 cell morphogenesis;GO:0020027 hemoglobin metabolic process;GO:0048536 spleen development;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49222-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52019-1", "uniprot_id": "ERG1_MOUSE", "mass": 63770.0, "length": 572, "protein_name": "Squalene monooxygenase", "gene_name": "Sqle", "organism": "Mouse", "refseq_name": "squalene monooxygenase", "refseq_ac": "NP_033296", "gene_names_uniprotkb": "Sqle; Erg1", "gene_names_refseq": "Sqle", "protein_names_uniprotkb": "Squalene monooxygenase; 1.14.14.17; SE; Squalene epoxidase", "protein_names_refseq": "SE; squalene monooxygenase", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20775); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15598878;25428506;30084848;7873613", "class_list": "", "function": "Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis., [UniProtKB, UniProtKB]; Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.17", "go_molecular_function": "GO:0071949 FAD binding;GO:0004506 squalene monooxygenase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0042127 regulation of cell population proliferation;GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70695-1", "uniprot_id": "F16P2_MOUSE", "mass": 36947.0, "length": 339, "protein_name": "Fructose-1,6-bisphosphatase isozyme 2", "gene_name": "Fbp2", "organism": "Mouse", "refseq_name": "fructose-1,6-bisphosphatase isozyme 2", "refseq_ac": "NP_032020", "gene_names_uniprotkb": "Fbp2", "gene_names_refseq": "Fbp-1; Fbp1; Fbp2; Rae-30", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase isozyme 2; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; Muscle FBPase; RAE-30", "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; FBPase muscle; fructose-1,6-bisphosphatase isozyme 2; muscle FBPase", "tax_id": 10090, "disease": "", "pathway": " (mmu:14120); (R-MMU-70263)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10773464;11250076;32492972;32962293;33946543;37507081;37828378;8034042", "class_list": "glycogene", "function": "Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate., [UniProtKB, PubMed]; Cobalt Regulates Activation of Camk2alpha in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Fbp2, a Newly Discovered Constituent of Memory Formation Mechanisms, Is Regulated by Astrocyte-Neuron Crosstalk. Publication Status: Online-Only, [RefSeq, PubMed]; Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X26;Q9JK01;Q9JK02;Q9JK03;Q9JK04;Q9JK05;Q9JK06;Q9JK07;Q9JK08;Q9JK09;Q9QXB4;Q9QXB5;Q9QXB6;Q9QXD7", "ec_number_list": "3.1.3.11", "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030018 Z disc", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00558-1", "uniprot_id": "HAP40_MOUSE", "mass": 40474.0, "length": 381, "protein_name": "40-kDa huntingtin-associated protein", "gene_name": "F8a1", "organism": "Mouse", "refseq_name": "40-kDa huntingtin-associated protein", "refseq_ac": "NP_032004", "gene_names_uniprotkb": "F8a1; F8a; Hap40", "gene_names_refseq": "DXUcsf1; F8a1; F8a", "protein_names_uniprotkb": "40-kDa huntingtin-associated protein; CpG island protein; Factor VIII intron 22 protein", "protein_names_refseq": "40-kDa huntingtin-associated protein; Factor VIII associated protein; cpG island protein; factor VIII intron 22 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14070)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11035034;1639415;16476778;23749422;35820727;38744826", "class_list": "", "function": "HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice. Publication Status: Online-Only, [RefSeq, PubMed]; RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLS9;Q9JJQ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0016604 nuclear body", "go_biological_process": "GO:1901799 negative regulation of proteasomal protein catabolic process;GO:0099518 vesicle cytoskeletal trafficking", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0KK56-1", "uniprot_id": "F184B_MOUSE", "mass": 107601.0, "length": 942, "protein_name": "Protein FAM184B", "gene_name": "Fam184b", "organism": "Mouse", "refseq_name": "protein FAM184B", "refseq_ac": "NP_067391", "gene_names_uniprotkb": "Fam184b; Kiaa1276; MNCb-2622", "gene_names_refseq": "9630031F12Rik; Fam184b", "protein_names_uniprotkb": "Protein FAM184B", "protein_names_refseq": "protein FAM184B", "tax_id": 10090, "disease": "", "pathway": " (mmu:58227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16807365", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KK51;Q76KB4;Q7TNB6;Q9JJG2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0KK56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VAY3-1", "uniprot_id": "F187B_MOUSE", "mass": 40957.0, "length": 358, "protein_name": "Protein FAM187B", "gene_name": "Fam187b", "organism": "Mouse", "refseq_name": "protein FAM187B isoform 1 precursor", "refseq_ac": "NP_780449", "gene_names_uniprotkb": "Fam187b; Tmem162", "gene_names_refseq": "1700020B09Rik; Fam187b; Tmem162", "protein_names_uniprotkb": "Protein FAM187B; Transmembrane protein 162", "protein_names_refseq": "protein FAM187B isoform 1 precursor; protein FAM187B; transmembrane protein 162", "tax_id": 10090, "disease": "", "pathway": " (mmu:76415)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFH7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VAY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TCT4-1", "uniprot_id": "ENTP7_MOUSE", "mass": 68974.0, "length": 606, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 7", "gene_name": "Entpd7", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 7", "refseq_ac": "NP_444333", "gene_names_uniprotkb": "Entpd7; Kiaa4066; Lalp1", "gene_names_refseq": "1810012B13Rik; 1810020C02Rik; 2810003F23Rik; Entpd7; LALP1; Lysal2", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 7; 3.6.1.15; Lysosomal apyrase-like protein 1; NTPDase 7", "protein_names_refseq": "NTPDase 7; ectonucleoside triphosphate diphosphohydrolase 7; lysosomal apyrase-like 2; lysosomal apyrase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:93685); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11278936;23241884;34428180", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes nucleoside diphosphates only to a minor extent (By similarity). In contrast to its human ortholog is able to hydrolyze ATP. In the epithelial cells of small intestine controls luminal ATP levels, therefore regulating Th17-cell development (PubMed:23241884)., [UniProtKB, UniProtKB, PubMed]; ENTPDase7 controls the luminal ATP level and, thereby, regulates Th17 cell development in the small intestine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EHD3;Q3TM04;Q571A5;Q9ET10", "ec_number_list": "3.6.5.-;3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.6.5.2;3.1.13.1;5.6.2.6;3.6.5.3;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;3.6.5.4;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.5.5;3.6.4.6;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;2.7.11.1;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.1.6;3.6.1.42", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0034656 nucleobase-containing small molecule catabolic process;GO:0050776 regulation of immune response;GO:0046039 GTP metabolic process;GO:0072539 T-helper 17 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TCT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVG3-1", "uniprot_id": "F91A1_MOUSE", "mass": 93464.0, "length": 837, "protein_name": "Protein FAM91A1", "gene_name": "Fam91a1", "organism": "Mouse", "refseq_name": "protein FAM91A1 isoform 1", "refseq_ac": "NP_666071", "gene_names_uniprotkb": "Fam91a1; D15Ertd621e; Kiaa0493", "gene_names_refseq": "D15Ertd621e; Fam91a1; SKIN; mKIAA0493", "protein_names_uniprotkb": "Protein FAM91A1", "protein_names_refseq": "protein FAM91A1 isoform 1; protein FAM91A1; skeletal muscle cells re-entry induced", "tax_id": 10090, "disease": "", "pathway": " (mmu:210998); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21183079;25428506;29084197;30059200;30084848;30779550;34203471;34428180;35820727", "class_list": "", "function": "As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80TZ0;Q8K077", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099041 vesicle tethering to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UVG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1V3-1", "uniprot_id": "ESF1_MOUSE", "mass": 98048.0, "length": 845, "protein_name": "ESF1 homolog", "gene_name": "Esf1", "organism": "Mouse", "refseq_name": "ESF1 homolog", "refseq_ac": "NP_001074559", "gene_names_uniprotkb": "Esf1; Abtap", "gene_names_refseq": "2610101J03Rik; ABTAP; Esf1", "protein_names_uniprotkb": "ESF1 homolog; ABT1-associated protein", "protein_names_refseq": "ABT1-associated protein; ESF1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66580)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15660422;19131326;19144319;21183079;22872234;25428506;31219806;34428180;34887587;36210013", "class_list": "", "function": "May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)., [UniProtKB]; The Rattus rattus ABT1-associated protein formed a complex with ABT1 and suppressed activation of Pol II-directed transcription in mammalian cells. It binds and negatively regulates ABT1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3V1V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZN08-1", "uniprot_id": "F220A_MOUSE", "mass": 27752.0, "length": 260, "protein_name": "Protein FAM220A", "gene_name": "Fam220a", "organism": "Mouse", "refseq_name": "protein FAM220A", "refseq_ac": "NP_080326", "gene_names_uniprotkb": "Fam220a; Acpin1; Sipar", "gene_names_refseq": "1500026F15Rik; 2810453I06Rik; Acpin1; Fam220a; Sipar", "protein_names_uniprotkb": "Protein FAM220A; Acrosomal protein ACPIN1; STAT3-interacting protein as a repressor", "protein_names_refseq": "STAT3-interacting protein as a repressor; acrosomal protein ACPIN1; protein FAM220A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67238)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19659802;23917203;26026268;30731284", "class_list": "", "function": "Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2 (PubMed:23917203, PubMed:26026268). This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity (PubMed:23917203, PubMed:26026268). May be required for spermiogenesis or sperm function (PubMed:19659802)., [UniProtKB, PubMed, PubMed, PubMed]; Results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus, [RefSeq, PubMed]; SIPAR, functioning as a new negative regulator, inhibits STAT3 activity by enhancing its dephosphorylation and represses melanoma progression., [RefSeq, PubMed]; Tgfb2 and Fam220a were identified as putative targets of miR-489-3p and miR-92a-3p, respectively; inhibition endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis, [RefSeq, PubMed]; The two ORFs on the Acpin1 mRNA are independently translated in differentiated cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVG9;Q8BPE1;Q99JV7;Q9D5Z1", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3ZN08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497Q6-1", "uniprot_id": "F228B_MOUSE", "mass": 27823.0, "length": 232, "protein_name": "Protein FAM228B", "gene_name": "Fam228b", "organism": "Mouse", "refseq_name": "protein FAM228B isoform b", "refseq_ac": "NP_780640", "gene_names_uniprotkb": "Fam228b", "gene_names_refseq": "A830093I24Rik; Fam228b", "protein_names_uniprotkb": "Protein FAM228B", "protein_names_refseq": "UPF0638 protein B; protein FAM228B isoform b; protein FAM228B", "tax_id": 10090, "disease": "", "pathway": " (mmu:207921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLM3;Q8BWN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q497Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5MPP0-1", "uniprot_id": "FA2H_MOUSE", "mass": 42981.0, "length": 372, "protein_name": "Fatty acid 2-hydroxylase", "gene_name": "Fa2h", "organism": "Mouse", "refseq_name": "fatty acid 2-hydroxylase", "refseq_ac": "NP_835187", "gene_names_uniprotkb": "Fa2h; Faah", "gene_names_refseq": "FAAH; Fa2h; Faxdc1; G630055L08Rik", "protein_names_uniprotkb": "Fatty acid 2-hydroxylase; 1.14.18.-; Fatty acid alpha-hydroxylase", "protein_names_refseq": "fatty acid 2-hydroxylase; fatty acid alpha-hydroxylase; fatty acid hydroxylase domain containing 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 35 (Disease Ontology:DOID:0110786)", "pathway": " (mmu:338521); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15658937;16998236;18815260;21628453;22517924;25428506;34428180;35445918;36274060", "class_list": "", "function": "Age-Dependent Increase in Schmidt-Lanterman Incisures and a Cadm4-Associated Membrane Skeletal Complex in Fatty Acid 2-hydroxylase Deficient Mice: a Mouse Model of Spastic Paraplegia SPG35., [RefSeq, PubMed]; Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15658937, PubMed:16998236, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:15658937, PubMed:18815260). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (PubMed:21628453). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (PubMed:22517924)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. Erratum:[Signal Transduct Target Ther. 2025 Sep 7;10(1):305. doi: 10.1038/s41392-025-02379-5. PMID: 40915995] Publication Status: Online-Only, [RefSeq, PubMed]; FA2H is the enzyme responsible for the formation of alpha-hydroxylated ceramide in oligodendrocytes of the mammalian brain., [RefSeq, PubMed]; FA2H is the major fatty acid 2-hydroxylase in brain, and 2-hydroxylation of free fatty acids is the first step in the synthesis of 2-hydroxy galactolipids, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2M0;Q5RL53;Q8BTH1;Q8R0M0;Q8R0V1", "ec_number_list": "1.14.18.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0080132 fatty acid 2-hydroxylase activity;GO:0120520 free fatty acid 2-hydroxylase activity;GO:0120521 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0042127 regulation of cell population proliferation;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5MPP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NC57-1", "uniprot_id": "CF144_MOUSE", "mass": 16125.0, "length": 135, "protein_name": "Cilia- and flagella-associated protein 144", "gene_name": "Cfap144", "organism": "Mouse", "refseq_name": "cilia- and flagella-associated protein 144 isoform 2", "refseq_ac": "NP_001156350", "gene_names_uniprotkb": "Cfap144; Fam183b; Theg6", "gene_names_refseq": "3100002J23Rik; Cfap144; Fam183b; Theg6", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 144; Testis highly expressed protein 6", "protein_names_refseq": "cilia- and flagella-associated protein 144 isoform 2; family with sequence similarity 183, member B; protein FAM183B; testis highly expressed protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:75429)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;27914912;30279523;37295417", "class_list": "", "function": "Surprisingly, mice homozygous for a null allele did not display any defects indicative of disrupted motile ciliary function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2D553;Q3TZB7;Q9CXW5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0005879 axonemal microtubule;GO:0097546 ciliary base", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5NC57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SVT3-1", "uniprot_id": "ETAA1_MOUSE", "mass": 96552.0, "length": 877, "protein_name": "Ewing's tumor-associated antigen 1 homolog", "gene_name": "Etaa1", "organism": "Mouse", "refseq_name": "ewing's tumor-associated antigen 1 homolog isoform 1", "refseq_ac": "NP_080852", "gene_names_uniprotkb": "Etaa1", "gene_names_refseq": "5730466H23Rik; Etaa1", "protein_names_uniprotkb": "Ewing's tumor-associated antigen 1 homolog", "protein_names_refseq": "ewing's tumor-associated antigen 1 homolog isoform 1; ewing's tumor-associated antigen 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68145)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28607084;34428180", "class_list": "", "function": "ETAA1 deficiency decreased clonal expansion cell autonomously within the responding T cells, causing no decrease in their division rate but increasing TP53-induced mRNAs and phosphorylation of H2AX, a marker of DNA replication stress induced by the ATM and ATR kinases., [RefSeq, PubMed]; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZM6;Q8K332;Q9CS19;Q9D2Z9", "ec_number_list": "", "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006281 DNA repair;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006974 DNA damage response;GO:0071902 positive regulation of protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SVT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SWY7-1", "uniprot_id": "FA83G_MOUSE", "mass": 89830.0, "length": 812, "protein_name": "Protein FAM83G", "gene_name": "Fam83g", "organism": "Mouse", "refseq_name": "protein FAM83G", "refseq_ac": "NP_848733", "gene_names_uniprotkb": "Fam83g", "gene_names_refseq": "2310040C09Rik; Fam83g; Sack1g; wly", "protein_names_uniprotkb": "Protein FAM83G", "protein_names_refseq": "family with sequence similarity 83, member G; protein FAM83G", "tax_id": 10090, "disease": "", "pathway": " (mmu:69640)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23656696;25428506;27802388;29963719;34144502;34428180;35820727", "class_list": "", "function": "FAM83G promotes proliferation, invasion, and metastasis by regulating PI3K/AKT signaling in hepatocellular carcinoma cells., [RefSeq, PubMed]; In this study, we demonstrate that FAM83G/Fam83g is associated with hair morphogenesis, differentiation and cycling and provide first insights into functional consequences of FAM83G/Fam83g variants., [RefSeq, PubMed]; Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways., [UniProtKB, UniProtKB]; Suggest that this mutation in Fam83g is the likely basis of the mouse wooly phenotype Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U437;Q8C1B0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5SWY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQV1-1", "uniprot_id": "INY2B_MOUSE", "mass": 59102.0, "length": 535, "protein_name": "INSYN2B protein", "gene_name": "Insyn2b", "organism": "Mouse", "refseq_name": "INSYN2B protein", "refseq_ac": "NP_001020553", "gene_names_uniprotkb": "Insyn2b; Fam196b", "gene_names_refseq": "EG574403; Fam196b; Gm6041; Insyn2b", "protein_names_uniprotkb": "INSYN2B protein; Inhibitory synaptic factor family member 2B", "protein_names_refseq": "INSYN2B protein; family with sequence similarity 196, member B; protein FAM196B", "tax_id": 10090, "disease": "", "pathway": " (mmu:574403)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GQV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGF7-1", "uniprot_id": "EXOC8_MOUSE", "mass": 81035.0, "length": 716, "protein_name": "Exocyst complex component 8", "gene_name": "Exoc8", "organism": "Mouse", "refseq_name": "exocyst complex component 8", "refseq_ac": "NP_932771", "gene_names_uniprotkb": "Exoc8", "gene_names_refseq": "EXO84; Exo84p; Exoc8; SEC84", "protein_names_uniprotkb": "Exocyst complex component 8; Exocyst complex 84 kDa subunit", "protein_names_refseq": "exocyst complex 84 kDa subunit; exocyst complex component 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:102058); (R-MMU-264876); (R-MMU-5620916)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15345747;25428506;28325821;32848054", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Data show that TBK1 directly interacts with Exo84 through the coiled-coil domain of TBK1 and helical domain of Exo84, and knockdown of TBK1 blocked insulin-stimulated glucose uptake and GLUT4 translocation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0015031 protein transport;GO:0022617 extracellular matrix disassembly;GO:0007032 endosome organization;GO:0000281 mitotic cytokinesis;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PGF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6SP97-1", "uniprot_id": "ENKUR_MOUSE", "mass": 29527.0, "length": 255, "protein_name": "Enkurin", "gene_name": "Enkur", "organism": "Mouse", "refseq_name": "enkurin", "refseq_ac": "NP_082004", "gene_names_uniprotkb": "Enkur", "gene_names_refseq": "4933434I06Rik; Enkur", "protein_names_uniprotkb": "Enkurin", "protein_names_refseq": "enkurin", "tax_id": 10090, "disease": "", "pathway": " (mmu:71233)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15385169;17971504;29733335;34428180;37295417;37865089;37989994", "class_list": "", "function": "4933434I06Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (PubMed:15385169). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data suggest that enkurin is an adaptor that functions to localize a Ca2+ sensitive signal transduction machinery in sperm to a Ca2+-permeable ion channel [enkurin], [RefSeq, PubMed]; Sperm flagella of mice homozygous for a mutated allele displayed only asymmetric bending, nonprogressive motility, and a loss of Ca2+-responsiveness following demembranation. We propose that Enkurin is part of a flagellar Ca2+-sensor that regulates bending and that the motility defects following mutation of the locus are the proximate cause of subfertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6SP97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNT2-1", "uniprot_id": "FACR2_MOUSE", "mass": 59167.0, "length": 515, "protein_name": "Fatty acyl-CoA reductase 2", "gene_name": "Far2", "organism": "Mouse", "refseq_name": "fatty acyl-CoA reductase 2 isoform 1", "refseq_ac": "NP_001334445", "gene_names_uniprotkb": "Far2", "gene_names_refseq": "A230046P18; Far2; Mlstd1", "protein_names_uniprotkb": "Fatty acyl-CoA reductase 2; 1.2.1.84; Far2", "protein_names_refseq": "fatty acyl-CoA reductase 2 isoform 1; male sterility domain-containing protein 1", "tax_id": 10090, "disease": "dry eye syndrome (Disease Ontology:DOID:10140); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:330450); (R-MMU-9640463)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15220348;15220349;20173027;24009241;30084848;34428180;35238077", "class_list": "", "function": "Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348). A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). Can produce very long-chain and ultra long-chain FAls, regardless of whether they have a straight or branched chain (PubMed:35238077). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (PubMed:35238077)., [UniProtKB, PubMed, PubMed]; Fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids, [RefSeq, PubMed]; Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention., [RefSeq, PubMed]; Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it., [RefSeq, PubMed]; Wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KFC6;Q3TTT7;Q8BH72;Q8CAK7", "ec_number_list": "1.2.1.84", "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0010025 wax biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TNT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPD2-1", "uniprot_id": "F185A_MOUSE", "mass": 39992.0, "length": 378, "protein_name": "Protein FAM185A", "gene_name": "Fam185a", "organism": "Mouse", "refseq_name": "protein FAM185A isoform 1", "refseq_ac": "NP_808537", "gene_names_uniprotkb": "Fam185a", "gene_names_refseq": "4631428I10; Fam185a", "protein_names_uniprotkb": "Protein FAM185A", "protein_names_refseq": "protein FAM185A isoform 1; protein FAM185A", "tax_id": 10090, "disease": "", "pathway": " (mmu:330050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6A4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TPD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80V62-1", "uniprot_id": "FACD2_MOUSE", "mass": 163618.0, "length": 1450, "protein_name": "Fanconi anemia group D2 protein homolog", "gene_name": "Fancd2", "organism": "Mouse", "refseq_name": "Fanconi anemia group D2 protein homolog isoform 1", "refseq_ac": "NP_001028416", "gene_names_uniprotkb": "Fancd2", "gene_names_refseq": "2410150O07Rik; FA-D2; FA4; FACD; FAD; FANCD; Fancd2", "protein_names_uniprotkb": "Fanconi anemia group D2 protein homolog; Protein FACD2", "protein_names_refseq": "Fanconi anemia group D2 protein homolog isoform 1; fanconi anemia group D2 protein homolog", "tax_id": 10090, "disease": "Fanconi anemia complementation group D2 (Disease Ontology:DOID:0111083); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:211651); (R-MMU-6783310)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12893777;15199141;15377654;21750661;21764741;22872234;25605945;30084848;30779550;34428180;38229567;39627609", "class_list": "", "function": "FANCD2 deficiency sensitizes SHH medulloblastoma to radiotherapy via ferroptosis., [RefSeq, PubMed]; FANCD2, which is activated by the Fanconi anemia complex, is required to maintain the G2 checkpoint, [RefSeq, PubMed]; Fanconi anemia complementation group D2 knockout mice develop epithelial cancer., [RefSeq, PubMed]; Required for maintenance of chromosomal stability (PubMed:12893777). Promotes accurate and efficient pairing of homologs during meiosis (By similarity). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (By similarity). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (By similarity). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin (By similarity). May also be involved in B-cell immunoglobulin isotype switching (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results demonstrate that monoubiquitination of FANCD2, which is regulated by the FA pathway, promotes BRCA2 loading into chromatin complexes. These complexes appear to be required for normal homology-directed DNA repair., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWC7", "ec_number_list": "", "go_molecular_function": "GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:2000348 regulation of CD40 signaling pathway;GO:0010332 response to gamma radiation;GO:0006974 DNA damage response;GO:0034599 cellular response to oxidative stress;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80V62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VD1-1", "uniprot_id": "FA98B_MOUSE", "mass": 45349.0, "length": 429, "protein_name": "tRNA-splicing ligase complex subunit FAM98B", "gene_name": "Fam98b", "organism": "Mouse", "refseq_name": "tRNA-splicing ligase complex subunit FAM98B", "refseq_ac": "NP_080896", "gene_names_uniprotkb": "Fam98b", "gene_names_refseq": "2610510H03Rik; Fam98b", "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit FAM98B", "protein_names_refseq": "protein FAM98B; tRNA-splicing ligase complex subunit FAM98B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68215)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "20173027;22645316;25428506;28135057;29187734;30084848;30779550;31219806;34428180;37453647;37919785", "class_list": "", "function": "Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity and may function toward other RNAs. Could regulate the expression of PRMT1, a protein arginine N-methyltransferase., [UniProtKB, UniProtKB]; LncRNA-Gm9866 promotes liver fibrosis by activating TGFbeta/Smad signaling via targeting Fam98b. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ATZ4;Q9CS28;Q9CS37", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0006479 protein methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80VD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VR2-1", "uniprot_id": "ELL3_MOUSE", "mass": 44762.0, "length": 395, "protein_name": "RNA polymerase II elongation factor ELL3", "gene_name": "Ell3", "organism": "Mouse", "refseq_name": "RNA polymerase II elongation factor ELL3", "refseq_ac": "NP_666085", "gene_names_uniprotkb": "Ell3", "gene_names_refseq": "A930015D22Rik; Ell3", "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL3", "protein_names_refseq": "RNA polymerase II elongation factor ELL3", "tax_id": 10090, "disease": "", "pathway": " (mmu:269344); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20159561;22768269;23273992;34428180;37591949", "class_list": "", "function": "Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT)., [UniProtKB, PubMed, PubMed]; Study found that Ell3, a member of the Ell (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II elongation factors, occupies enhancers in embryonic stem cells., [RefSeq, PubMed]; The present results suggest that Ell3 promotes the differentiation of mouse embryonic stem cells by activating the expression of epithelial-mesenchymal transition-related genes and by suppressing p53 expression., [RefSeq, PubMed]; Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naive pluripotency in embryonic stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARQ1", "ec_number_list": "", "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0006366 transcription by RNA polymerase II;GO:2000179 positive regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80VR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XS7-1", "uniprot_id": "FA83E_MOUSE", "mass": 52578.0, "length": 481, "protein_name": "Protein FAM83E", "gene_name": "Fam83e", "organism": "Mouse", "refseq_name": "protein FAM83E", "refseq_ac": "NP_001028342", "gene_names_uniprotkb": "Fam83e", "gene_names_refseq": "4930403C10Rik; Fam83e; Sack1e", "protein_names_uniprotkb": "Protein FAM83E", "protein_names_refseq": "family with sequence similarity 83, member E; protein FAM83E", "tax_id": 10090, "disease": "", "pathway": " (mmu:73813)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "May play a role in MAPK signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIA0;Q3UN25", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80XS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YD3-1", "uniprot_id": "S31F3_MOUSE", "mass": 41486.0, "length": 371, "protein_name": "Protein SPATA31F3", "gene_name": "Spata31f3", "organism": "Mouse", "refseq_name": "protein SPATA31F3 isoform 1", "refseq_ac": "NP_808453", "gene_names_uniprotkb": "Spata31f3; Fam205c", "gene_names_refseq": "4931430D02; FAM205CP; Fam205c; Spata31f3", "protein_names_uniprotkb": "Protein SPATA31F3; Protein FAM205C", "protein_names_refseq": "family with sequence similarity 205, member C; protein FAM205CP homolog; protein SPATA31F3 isoform 1; protein SPATA31F3; transmembrane protein ENSP00000340100 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:277773)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5W8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGB7-1", "uniprot_id": "ENOPH_MOUSE", "mass": 28600.0, "length": 257, "protein_name": "Enolase-phosphatase E1", "gene_name": "Enoph1", "organism": "Mouse", "refseq_name": "enolase-phosphatase E1", "refseq_ac": "NP_001156507", "gene_names_uniprotkb": "Enoph1; Masa", "gene_names_refseq": "2310057D15Rik; Enoph1", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77; MASA homolog", "protein_names_refseq": "2,3-diketo-5-methylthio-1-phosphopentane phosphatase; MASA homolog; enolase-phosphatase E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67870); (R-MMU-1237112)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19139748;24236849;37075968", "class_list": "", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP]; Both single-nucleotide polymorphisms were significantly associated with locomotion-independent trait anxiety, further supporting a functional role of EP for this phenotype., [RefSeq, PubMed]; Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP., [RefSeq, PubMed]; Our result suggests a significant role for enoph1 and polyamines in anxiety and depression-related behaviors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGK8;Q3TXA2;Q3U8Y4;Q8VC92;Q9D6U4", "ec_number_list": "3.1.3.77", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR63-1", "uniprot_id": "F177A_MOUSE", "mass": 23578.0, "length": 207, "protein_name": "Protein FAM177A", "gene_name": "Fam177a2; Fam177a", "organism": "Mouse", "refseq_name": "protein FAM177A1", "refseq_ac": "NP_001093586", "gene_names_uniprotkb": "Fam177a2; Fam177a", "gene_names_refseq": "1700047I17Rik2; Fam177a2", "protein_names_uniprotkb": "Protein FAM177A", "protein_names_refseq": "protein FAM177A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100101807); (mmu:73385)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;25428506;30084848;31219806", "class_list": "", "function": "May act as a negative regulator of the IL-1beta immunogenic cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9M7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BR63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSN9-1", "uniprot_id": "FAKD3_MOUSE", "mass": 75317.0, "length": 661, "protein_name": "FAST kinase domain-containing protein 3, mitochondrial", "gene_name": "Fastkd3", "organism": "Mouse", "refseq_name": "FAST kinase domain-containing protein 3, mitochondrial", "refseq_ac": "NP_001317352", "gene_names_uniprotkb": "Fastkd3", "gene_names_refseq": "2310010B21Rik; Fastkd3", "protein_names_uniprotkb": "FAST kinase domain-containing protein 3, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 3, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:69577)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20869947;21750661;40885482", "class_list": "", "function": "Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity., [UniProtKB, UniProtKB]; These results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XKD3;Q6P9N4;Q8CB52;Q8CCG7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation;GO:0044528 regulation of mitochondrial mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BSN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTJ4-1", "uniprot_id": "ENPP4_MOUSE", "mass": 51611.0, "length": 456, "protein_name": "Bis(5'-adenosyl)-triphosphatase enpp4", "gene_name": "Enpp4", "organism": "Mouse", "refseq_name": "bis(5'-adenosyl)-triphosphatase enpp4 isoform 1 precursor", "refseq_ac": "NP_950181", "gene_names_uniprotkb": "Enpp4; Kiaa0879", "gene_names_refseq": "4933413N07Rik; E-NPP 4; Enpp4; Gm90", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase enpp4; 3.6.1.29; AP3A hydrolase; AP3Aase; E-NPP 4; Ectonucleotide pyrophosphatase/phosphodiesterase family member 4; NPP-4", "protein_names_refseq": "AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase enpp4 isoform 1 precursor; bis(5'-adenosyl)-triphosphatase enpp4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:224794); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;19349973;25428506;25605945;26192747;26495903;26740625;26823374;30899004;31599954;33300544;34428180", "class_list": "", "function": "Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity)., [UniProtKB]; These results indicate that zinc remains inside the ENPP4 protein, a Bacillus Calmette-Guerin activated tumoricidal macrophage protein, throughout the simulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZS2;Q69ZX0;Q8K1L3", "ec_number_list": "2.3.2.27;3.6.1.29;3.9.1.-;2.7.7.51;3.6.2.1;3.6.5.2;3.2.1.20;3.1.3.-;3.1.3.48;3.4.24.-;3.6.1.-;3.1.4.1;3.6.1.9;3.4.16.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0030194 positive regulation of blood coagulation;GO:0046130 purine ribonucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8BTJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUP8-1", "uniprot_id": "FA43A_MOUSE", "mass": 46206.0, "length": 424, "protein_name": "Protein FAM43A", "gene_name": "Fam43a", "organism": "Mouse", "refseq_name": "protein FAM43A", "refseq_ac": "NP_808300", "gene_names_uniprotkb": "Fam43a", "gene_names_refseq": "Fam43a; Tuf1", "protein_names_uniprotkb": "Protein FAM43A", "protein_names_refseq": "protein FAM43A; somitovasculin", "tax_id": 10090, "disease": "", "pathway": " (mmu:224093)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19542019;30084848;31219806;34428180", "class_list": "", "function": "We have shown the participation of a novel transcript (named somitovasculin) in circulatory vessel development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FTY9;Q8R231", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BUP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYI8-1", "uniprot_id": "F234B_MOUSE", "mass": 67031.0, "length": 624, "protein_name": "Protein FAM234B", "gene_name": "Fam234b", "organism": "Mouse", "refseq_name": "protein FAM234B isoform 2", "refseq_ac": "NP_083258", "gene_names_uniprotkb": "Fam234b; 8430419L09Rik; Kiaa1467", "gene_names_refseq": "8430419L09Rik; Fam234b; mKIAA1467", "protein_names_uniprotkb": "Protein FAM234B", "protein_names_refseq": "protein FAM234B isoform 2; protein FAM234B", "tax_id": 10090, "disease": "", "pathway": " (mmu:74525)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;28011936;30899004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE07;Q5DTX5;Q8BYJ4;Q9CXB0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005815 microtubule organizing center", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BYI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C627-1", "uniprot_id": "F221B_MOUSE", "mass": 54292.0, "length": 487, "protein_name": "Protein FAM221B", "gene_name": "Fam221b", "organism": "Mouse", "refseq_name": "protein FAM221B", "refseq_ac": "NP_780726", "gene_names_uniprotkb": "Fam221b", "gene_names_refseq": "4930412F15Rik; Fam221b", "protein_names_uniprotkb": "Protein FAM221B", "protein_names_refseq": "protein FAM221B; uncharacterized protein C9orf128 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:242408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20485683", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VD71;Q8BGP2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB59-1", "uniprot_id": "F161B_MOUSE", "mass": 66969.0, "length": 589, "protein_name": "Protein FAM161B", "gene_name": "Fam161b", "organism": "Mouse", "refseq_name": "protein FAM161B", "refseq_ac": "NP_766169", "gene_names_uniprotkb": "Fam161b", "gene_names_refseq": "9330169D17; 9830169C18Rik; Fam161b", "protein_names_uniprotkb": "Protein FAM161B", "protein_names_refseq": "protein FAM161B", "tax_id": 10090, "disease": "", "pathway": " (mmu:217705)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQX8;Q8BSL9;Q8CBZ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CB59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDM8-1", "uniprot_id": "FHI2A_MOUSE", "mass": 86017.0, "length": 764, "protein_name": "FHF complex subunit HOOK interacting protein 2A", "gene_name": "Fhip2a", "organism": "Mouse", "refseq_name": "FHF complex subunit HOOK interacting protein 2A", "refseq_ac": "NP_663480", "gene_names_uniprotkb": "Fhip2a; Fam160b1; Kiaa1600", "gene_names_refseq": "Fam160b1; Fhip2a; mKIAA1600", "protein_names_uniprotkb": "FHF complex subunit HOOK interacting protein 2A", "protein_names_refseq": "FHF complex subunit HOOK interacting protein 2A; family with sequence similarity 160, member B1; protein FAM160B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:226252)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34678516", "class_list": "", "function": "May be required for proper functioning of the nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9P9;Q68FM8;Q6P5D5;Q80TB5;Q8C8M2;Q8R1V3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CDM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0L2-1", "uniprot_id": "ENTP8_MOUSE", "mass": 54650.0, "length": 497, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 8", "gene_name": "Entpd8", "organism": "Mouse", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 8", "refseq_ac": "NP_082369", "gene_names_uniprotkb": "Entpd8", "gene_names_refseq": "Entpd8", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 8; 3.6.1.5; E-NTPDase 8; NTPDase 8; NTPDase8", "protein_names_refseq": "E-NTPDase 8; NTPDase 8; NTPDase8; ectonucleoside triphosphate diphosphohydrolase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:72090); (R-MMU-8850843)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15122917;20173027;21750661;25605945;33452178;34428180;34548395", "class_list": "", "function": "Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (By similarity). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:15122917). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:15122917). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:15122917). Hydrolyzes ATP, UTP, ADP, and UDP and prefers triphosphonucleosides and adenine over uracil as substrates. Does not hydrolyzes AMP (PubMed:15122917)., [UniProtKB, PubMed, UniProtKB]; Enzymatic properties of NTPDase8 (Entpd8) differ from those of other NTPDases and suggest an alternative way to modulate nucleotide levels and consequently P2Y and P2X receptor activation., [RefSeq, PubMed]; NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD., [RefSeq, PubMed]; The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AJ99;Q6UQ22", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;3.6.1.6;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;3.6.1.16;3.6.1.53;3.6.1.42", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009124 nucleoside monophosphate biosynthetic process;GO:0009133 nucleoside diphosphate biosynthetic process;GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009191 ribonucleoside diphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K0L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1D8-1", "uniprot_id": "ENHO_MOUSE", "mass": 7927.0, "length": 76, "protein_name": "Adropin", "gene_name": "Enho", "organism": "Mouse", "refseq_name": "adropin precursor", "refseq_ac": "NP_081423", "gene_names_uniprotkb": "Enho", "gene_names_refseq": "1110065P19Rik; 2310040A07Rik; Enho", "protein_names_uniprotkb": "Adropin; Energy homeostasis-associated protein", "protein_names_refseq": "adropin precursor; adropin; energy homeostasis-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69638)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19041763;20837912;37654184;37743028", "class_list": "", "function": "A potential endothelial protective role of adropin that is likely mediated via upregulation of endothelial NO synthase expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and VEGFR2-extracellular signal regulated kinase 1/2 pathways. GeneRIF: Adropin has an endothelial protective function mediated via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for limiting diseases characterized by endothelial dysfunction., [RefSeq, PubMed]; Adropin attenuates pancreatitis-associated lung injury through PPARgamma phosphorylation-related macrophage polarization., [RefSeq, PubMed]; Adropin regulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis. GeneRIF: Adropin is the name given to the secreted peptide encoded by human C9orf165. In mice, it is abundant in liver where it is regulated by dietary macronutrients. Adropin regulates expression of genes involved in lipogenesis and adipogenesis., [RefSeq, PubMed]; Involved in the regulation of glucose homeostasis and lipid metabolism., [UniProtKB, PubMed]; Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0097009 energy homeostasis;GO:0045747 positive regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K1D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2D0-1", "uniprot_id": "F199X_MOUSE", "mass": 42839.0, "length": 388, "protein_name": "Protein FAM199X", "gene_name": "Fam199x", "organism": "Mouse", "refseq_name": "protein FAM199X", "refseq_ac": "NP_666373", "gene_names_uniprotkb": "Fam199x", "gene_names_refseq": "Fam199x", "protein_names_uniprotkb": "Protein FAM199X", "protein_names_refseq": "protein FAM199X", "tax_id": 10090, "disease": "", "pathway": " (mmu:245622)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AZH1;Q3U3R2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZW3-1", "uniprot_id": "F151A_MOUSE", "mass": 66681.0, "length": 608, "protein_name": "Protein FAM151A", "gene_name": "Fam151a", "organism": "Mouse", "refseq_name": "protein FAM151A", "refseq_ac": "NP_666261", "gene_names_uniprotkb": "Fam151a", "gene_names_refseq": "2010309H15Rik; Fam151a", "protein_names_uniprotkb": "Protein FAM151A", "protein_names_refseq": "protein FAM151A", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:230579)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8QZW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0W5-1", "uniprot_id": "EST4A_MOUSE", "mass": 62883.0, "length": 563, "protein_name": "Carboxylesterase 4A", "gene_name": "Ces4a", "organism": "Mouse", "refseq_name": "carboxylesterase 4A precursor", "refseq_ac": "NP_666325", "gene_names_uniprotkb": "Ces4a; Ces8", "gene_names_refseq": "Ces4a; Ces8", "protein_names_uniprotkb": "Carboxylesterase 4A; 3.1.1.-", "protein_names_refseq": "carboxylesterase 4A precursor; carboxylesterase 8 (putative)", "tax_id": 10090, "disease": "", "pathway": " (mmu:234677)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Probable carboxylesterase., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3XA24", "ec_number_list": "", "go_molecular_function": "GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R0W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1L4-1", "uniprot_id": "ERD23_MOUSE", "mass": 25111.0, "length": 214, "protein_name": "ER lumen protein-retaining receptor 3", "gene_name": "Kdelr3", "organism": "Mouse", "refseq_name": "ER lumen protein-retaining receptor 3", "refseq_ac": "NP_598851", "gene_names_uniprotkb": "Kdelr3", "gene_names_refseq": "Kdelr3", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3", "protein_names_refseq": "ER lumen protein-retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:105785); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "34428180;36614300", "class_list": "", "function": "E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVS1;Q91X67", "ec_number_list": "", "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network;GO:0030663 COPI-coated vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R1L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDI1-1", "uniprot_id": "ESIP1_MOUSE", "mass": 36098.0, "length": 314, "protein_name": "Epithelial-stromal interaction protein 1", "gene_name": "Epsti1", "organism": "Mouse", "refseq_name": "epithelial-stromal interaction protein 1 isoform a", "refseq_ac": "NP_083771", "gene_names_uniprotkb": "Epsti1", "gene_names_refseq": "2310046K10Rik; 5033415K03Rik; BRESI1; Epsti1", "protein_names_uniprotkb": "Epithelial-stromal interaction protein 1", "protein_names_refseq": "epithelial stromal interaction 1 (breast); epithelial-stromal interaction protein 1 isoform a; epithelial-stromal interaction protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108670); (R-MMU-9696273)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18250455;19144319;21183079;21750661;26495903;28011936;29187734;29217193;30084848;34428180;35778487", "class_list": "", "function": "EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression., [RefSeq, PubMed]; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (PubMed:29217193). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (PubMed:29217193)., [UniProtKB, PubMed]; These findings identify Epsti1 as a modulator of macrophage activation and polarization via the Stat1 and p65 pathways, and suggest a potentially important role of Epsti1 in immunotherapies against inflammatory diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WK5;Q8VDW6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0048873 homeostasis of number of cells within a tissue;GO:0071222 cellular response to lipopolysaccharide;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VDI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE88-1", "uniprot_id": "F1142_MOUSE", "mass": 54045.0, "length": 497, "protein_name": "Protein FAM114A2", "gene_name": "Fam114a2", "organism": "Mouse", "refseq_name": "protein FAM114A2 isoform 2", "refseq_ac": "NP_001162138", "gene_names_uniprotkb": "Fam114a2", "gene_names_refseq": "1810073G14Rik; 9030624B09Rik; Fam114a2", "protein_names_uniprotkb": "Protein FAM114A2", "protein_names_refseq": "protein FAM114A2 isoform 2; protein FAM114A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67726)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;22872234;28528544;31219806;34315090;34428180;36210013", "class_list": "", "function": "The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE42;Q5QNR1;Q9D310", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VE88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE94-1", "uniprot_id": "F110C_MOUSE", "mass": 45319.0, "length": 421, "protein_name": "Protein FAM110C", "gene_name": "Fam110c", "organism": "Mouse", "refseq_name": "protein FAM110C", "refseq_ac": "NP_082104", "gene_names_uniprotkb": "Fam110c", "gene_names_refseq": "9030611O19Rik; Fam110c", "protein_names_uniprotkb": "Protein FAM110C", "protein_names_refseq": "protein FAM110C", "tax_id": 10090, "disease": "", "pathway": " (mmu:104943)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;31219806", "class_list": "", "function": "May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9D322", "ec_number_list": "", "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005938 cell cortex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0060491 regulation of cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VE94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEH5-1", "uniprot_id": "EPMIP_MOUSE", "mass": 70096.0, "length": 606, "protein_name": "EPM2A-interacting protein 1", "gene_name": "Epm2aip1", "organism": "Mouse", "refseq_name": "EPM2A-interacting protein 1", "refseq_ac": "NP_780475", "gene_names_uniprotkb": "Epm2aip1; Kiaa0766", "gene_names_refseq": "A930003G21Rik; Epm2aip1; mKIAA0766", "protein_names_uniprotkb": "EPM2A-interacting protein 1; Laforin-interacting protein", "protein_names_refseq": "EPM2A (laforin) interacting protein 1; EPM2A-interacting protein 1; laforin-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:77781)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;24142699;25428506;28536304;30084848;30779550;31219806;34428180", "class_list": "", "function": "The authors conclude that laforin's principle function is to control glycogen chain lengths, in a malin-dependent fashion, and that loss of this control underlies Lafora disease., [RefSeq, PubMed]; We show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TS4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032868 response to insulin;GO:0045725 positive regulation of glycogen biosynthetic process;GO:2000467 positive regulation of glycogen (starch) synthase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VEH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V16-1", "uniprot_id": "ETFR1_MOUSE", "mass": 10391.0, "length": 86, "protein_name": "Electron transfer flavoprotein regulatory factor 1", "gene_name": "Etfrf1", "organism": "Mouse", "refseq_name": "electron transfer flavoprotein regulatory factor 1", "refseq_ac": "NP_001157100", "gene_names_uniprotkb": "Etfrf1; Lyrm5", "gene_names_refseq": "4930469P12Rik; Etfrf1; Ghiso; Lyrm5", "protein_names_uniprotkb": "Electron transfer flavoprotein regulatory factor 1; Growth hormone-inducible soluble protein; LYR motif-containing protein 5", "protein_names_refseq": "LYR motif containing 5; LYR motif-containing protein 5; electron transfer flavoprotein regulatory factor 1; growth hormone-inducible soluble protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67636)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15064703;37507081", "class_list": "", "function": "Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KFC1;Q675B1;Q8VDL7", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0090324 negative regulation of oxidative phosphorylation;GO:1901856 negative regulation of cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91V16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KI3-1", "uniprot_id": "EMC3_MOUSE", "mass": 29980.0, "length": 261, "protein_name": "ER membrane protein complex subunit 3", "gene_name": "Emc3", "organism": "Mouse", "refseq_name": "ER membrane protein complex subunit 3", "refseq_ac": "NP_780310", "gene_names_uniprotkb": "Emc3; Tmem111", "gene_names_refseq": "0610039A15Rik; Emc3; Pob; Tmem111", "protein_names_uniprotkb": "ER membrane protein complex subunit 3; Transmembrane protein 111", "protein_names_refseq": "ER membrane protein complex subunit 3; partial optokinetic response b; transmembrane protein 111", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:66087); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "29083321;32886670;33785873;34428180", "class_list": "", "function": "EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3., [RefSeq, PubMed]; Emc3 maintains intestinal homeostasis by preserving secretory lineages., [RefSeq, PubMed]; Loss of the ER membrane protein complex subunit Emc3 leads to retinal bipolar cell degeneration in aged mice. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIK3", "ec_number_list": "", "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99KI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR80-1", "uniprot_id": "FA32A_MOUSE", "mass": 13215.0, "length": 112, "protein_name": "Protein FAM32A", "gene_name": "Fam32a", "organism": "Mouse", "refseq_name": "protein FAM32A", "refseq_ac": "NP_080731", "gene_names_uniprotkb": "Fam32a; MNCb-3154; Otag12", "gene_names_refseq": "2510049I19Rik; Fam32a; OTAG-12; Otag12", "protein_names_uniprotkb": "Protein FAM32A; OTAG-12; Ovarian tumor associated gene 12", "protein_names_refseq": "ovarian tumor associated gene-12; protein FAM32A", "tax_id": 10090, "disease": "", "pathway": " (mmu:67922); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21339736;31219806", "class_list": "", "function": "May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth., [UniProtKB, PubMed]; Study showed that hOTAG-12b increases mRNAs of pro-apoptotic genes such as BAD, GADD45alpha and CIEDB, while inhibiting anti-apoptotic NAIP and Akt1 expression, suggesting that hOTAG-12b-induced apoptosis might be p53-independent, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5E4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CR80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CVI2-1", "uniprot_id": "F133B_MOUSE", "mass": 27952.0, "length": 245, "protein_name": "Protein FAM133B", "gene_name": "Fam133b", "organism": "Mouse", "refseq_name": "protein FAM133B", "refseq_ac": "NP_001035966", "gene_names_uniprotkb": "Fam133b", "gene_names_refseq": "2900022K02Rik; 5830415L20Rik; Fam133b", "protein_names_uniprotkb": "Protein FAM133B", "protein_names_refseq": "protein FAM133B", "tax_id": 10090, "disease": "", "pathway": " (mmu:68152)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19224205;20173027;21750661;22872234;30059200;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVR0;Q78HY5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CVI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1Y9-1", "uniprot_id": "SHL2B_MOUSE", "mass": 17448.0, "length": 158, "protein_name": "Protein shisa-like-2B", "gene_name": "Shisal2b", "organism": "Mouse", "refseq_name": "protein shisa-like-2B", "refseq_ac": "NP_084260", "gene_names_uniprotkb": "Shisal2b; Fam159b", "gene_names_refseq": "A930021C24Rik; Fam159b; Shisal2b", "protein_names_uniprotkb": "Protein shisa-like-2B", "protein_names_refseq": "family with sequence similarity 159, member B; membrane protein FAM159B; protein shisa-like-2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:77803)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D1Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D309-1", "uniprot_id": "FAM3B_MOUSE", "mass": 26152.0, "length": 235, "protein_name": "Protein FAM3B", "gene_name": "Fam3b", "organism": "Mouse", "refseq_name": "protein FAM3B precursor", "refseq_ac": "NP_065647", "gene_names_uniprotkb": "Fam3b; ORF9", "gene_names_refseq": "2-21; 9030624C24Rik; D16Jhu19e; Fam3b; ORF9; Pander", "protein_names_uniprotkb": "Protein FAM3B; Cytokine-like protein 2-21; PANDER; Pancreatic-derived factor", "protein_names_refseq": "cytokine-like protein 2-21; family with sequence similarity 3, member B; pancreatic-derived factor; protein FAM3B precursor; protein FAM3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:52793)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11707072;12160727;17962352;21750661;23333428;25679806;26123584;27394190;28549991;9750193", "class_list": "", "function": "F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression Publication Status: Online-Only, [RefSeq, PubMed]; In-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP., [RefSeq, PubMed]; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner., [UniProtKB, PubMed]; PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway., [RefSeq, PubMed]; These findings indicate that intestinal L cells are responsive to PANDER, and elevated PANDER levels impair GLP-1 production in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88417", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005641 nuclear envelope lumen", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA01-1", "uniprot_id": "EPPI_MOUSE", "mass": 15470.0, "length": 134, "protein_name": "Eppin", "gene_name": "Eppin", "organism": "Mouse", "refseq_name": "eppin precursor", "refseq_ac": "NP_083601", "gene_names_uniprotkb": "Eppin; Spinlw1", "gene_names_refseq": "1700024E17Rik; Eppin; Spinlw1", "protein_names_uniprotkb": "Eppin; Epididymal protease inhibitor; Serine protease inhibitor-like with Kunitz and WAP domains 1", "protein_names_refseq": "epididymal protease inhibitor; eppin precursor; serine protease inhibitor-like with Kunitz and WAP domains 1; serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)", "tax_id": 10090, "disease": "", "pathway": " (mmu:75526); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12909348;16166195;21461566;23838579;25289806;32044375;33607572", "class_list": "", "function": "Ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays., [RefSeq, PubMed]; Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa., [RefSeq, PubMed]; Microarray expression profiling of whole adrenal mRNA from ovariectomized vs. intact mice demonstrated selective upregulation of gonadal-like genes including Spinlw1 and Insl3 in GDX-induced adrenocortical tumors of the mouse., [RefSeq, PubMed]; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity)., [UniProtKB]; SiRNA-mediated Eppin testicular silencing causes changes in sperm motility and calcium currents in mice., [RefSeq, PubMed]; The expression of mouse Eppin protein was detected in A1-A4 spermatogonia and the expression of human Eppin was detected in type A spermatogonia as well as in the earliest preleptotene spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5G9", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1901318 negative regulation of flagellated sperm motility;GO:0010466 negative regulation of peptidase activity;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DA01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB54-1", "uniprot_id": "F216A_MOUSE", "mass": 28339.0, "length": 251, "protein_name": "Protein FAM216A", "gene_name": "Fam216a", "organism": "Mouse", "refseq_name": "protein FAM216A", "refseq_ac": "NP_081159", "gene_names_uniprotkb": "Fam216a", "gene_names_refseq": "1500011H22Rik; Fam216a", "protein_names_uniprotkb": "Protein FAM216A", "protein_names_refseq": "protein FAM216A; uncharacterized protein C12orf24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68948)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UD74;Q6PFA4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DB54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQC4-1", "uniprot_id": "ELOV4_MOUSE", "mass": 36506.0, "length": 312, "protein_name": "Very long chain fatty acid elongase 4", "gene_name": "Elovl4", "organism": "Mouse", "refseq_name": "very long chain fatty acid elongase 4", "refseq_ac": "NP_683743", "gene_names_uniprotkb": "Elovl4", "gene_names_refseq": "Elovl4", "protein_names_uniprotkb": "Very long chain fatty acid elongase 4; 2.3.1.199; 3-keto acyl-CoA synthase Elovl4; ELOVL FA elongase 4; ELOVL fatty acid elongase 4; Elongation of very long chain fatty acids protein 4; Very long chain 3-ketoacyl-CoA synthase 4; Very long chain 3-oxoacyl-CoA synthase 4", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl4; ELOVL FA elongase 4; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; elongation of very long chain fatty acids protein 4; very long chain 3-ketoacyl-CoA synthase 4; very long chain 3-oxoacyl-CoA synthase 4; very long chain fatty acid elongase 4", "tax_id": 10090, "disease": "Stargardt disease (Disease Ontology:DOID:0050817); spinocerebellar ataxia 34 (Disease Ontology:DOID:0050981); corneal dystrophy (Disease Ontology:DOID:2566); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:83603)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11138005;12824221;12847421;15028285;18728184;21750661;22158834;22199362;22872234;23479632;23509295;24569140;30899004;33526677;34428180;35820727", "class_list": "glycogene", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; ELOVL4 may play an important role in embryonic development and in maintaining normal physiology of retina and brain at later stages of development, [RefSeq, PubMed]; Elovl4 expression in developing retina follows a dynamic pattern. It switches from predominant ganglion cell expression in embryonic and early postnatal development to predominant expression in the photoreceptor inner segments Publication Status: Online-Only, [RefSeq, PubMed]; Retinal bioavailability and functional effects of a synthetic very-long-chain polyunsaturated fatty acid in mice., [RefSeq, PubMed]; The ELOVL4 gene is highly conserved throughout evolution and is expressed in the photoreceptor cells of the retina in a variety of different species, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZV3", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0007623 circadian rhythm;GO:0006636 unsaturated fatty acid biosynthetic process;GO:1990926 short-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9EQC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1E6-1", "uniprot_id": "ENPP2_MOUSE", "mass": 98885.0, "length": 862, "protein_name": "Autotaxin", "gene_name": "Enpp2", "organism": "Mouse", "refseq_name": "autotaxin isoform 1", "refseq_ac": "NP_001129549", "gene_names_uniprotkb": "Enpp2; Npps2; Pdnp2", "gene_names_refseq": "ATX; E-NPP 2; Enpp2; Npps2; PD-Ialpha; Pdnp2; lysoPLD", "protein_names_uniprotkb": "Autotaxin; 3.1.4.39; 3.1.4.4; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D; LysoPLD", "protein_names_refseq": "autotaxin isoform 1; autotaxin; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2", "tax_id": 10090, "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (mmu:18606)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;10702660;12533192;15700135;17208043;18175805;19329427;21240269;21750661;23027977;23688339;25428506;27780639;28414242;29259743;30899004;31219806;31599954;35820727;38183947", "class_list": "", "function": "Dysregulated autotaxin expression by T cells in multiple sclerosis., [RefSeq, PubMed]; Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization., [RefSeq, PubMed]; Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:27780639, PubMed:28414242). Its major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639). Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition (By similarity). Possible involvement in cell proliferation and adipose tissue development (Probable). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A8UH85;A8UH93;B2ZP54;Q6PDE0;Q99LG9", "ec_number_list": "3.1.4.4;3.1.4.-;3.1.4.39", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0004630 phospholipase D activity;GO:0005044 scavenger receptor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0030149 sphingolipid catabolic process;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9R1E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2E3-1", "uniprot_id": "ERN2_MOUSE", "mass": 101262.0, "length": 911, "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE2", "gene_name": "Ern2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase/endoribonuclease IRE2 isoform 1 precursor", "refseq_ac": "NP_036146", "gene_names_uniprotkb": "Ern2; Ire2", "gene_names_refseq": "Ern1; Ern2; Ire1b; Ire1; ire1-beta; mIre1", "protein_names_uniprotkb": "Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; IRE1b; Inositol-requiring protein 2; Ire1-beta; mIre1", "protein_names_refseq": "endoplasmic reticulum (ER) to nucleus signalling 2; endoplasmic reticulum-to-nucleus signaling 2; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; inositol-requiring protein 2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform 1 precursor; serine/threonine-protein kinase/endoribonuclease IRE2", "tax_id": 10090, "disease": "", "pathway": " (mmu:26918)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11850408;35696049;35727638;36252035;36370432;37070943;9755171", "class_list": "", "function": "Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells., [RefSeq, PubMed]; Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway. Erratum:[Environ Toxicol. 2025 Jan;40(1):152-153. doi: 10.1002/tox.24402. PMID: 39189740], [RefSeq, PubMed]; IRE1-mediated unconventional mRNA splicing is involved in regulating XBP1 in signaling the unfolded protein response., [RefSeq, PubMed]; Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress., [RefSeq, PubMed]; Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein., [UniProtKB, PubMed]; The IRE1/JNK signaling pathway regulates inflammation cytokines and production of glomerular extracellular matrix in the acute kidney injury to chronic kidney disease transition., [RefSeq, PubMed]; The epithelial-specific ER stress sensor ERN2/IRE1beta enables host-microbiota crosstalk to affect colon goblet cell development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5E3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006468 protein phosphorylation;GO:0036498 IRE1-mediated unfolded protein response;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z2E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07235-1", "uniprot_id": "GDN_MOUSE", "mass": 44207.0, "length": 397, "protein_name": "Glia-derived nexin", "gene_name": "Serpine2", "organism": "Mouse", "refseq_name": "glia-derived nexin precursor", "refseq_ac": "NP_033281", "gene_names_uniprotkb": "Serpine2; Pi7; Pn1; Spi4", "gene_names_refseq": "B230326M24Rik; PAI-1; PI-7; PI7; PN-1; Serpine2; Spi4", "protein_names_uniprotkb": "Glia-derived nexin; GDN; PI-7; PN-1; Peptidase inhibitor 7; Protease nexin 1; Protease nexin I; Serine protease-inhibitor 4; Serpin E2", "protein_names_refseq": "GDN; glia-derived nexin precursor; glia-derived nexin; peptidase inhibitor 7; protease nexin 1; protease nexin I; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease-inhibitor 4; serpin E2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain edema (Disease Ontology:DOID:4724)", "pathway": " (mmu:20720); (R-MMU-75205); (R-MMU-9769733); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12542794;21750661;26495903;30084848;30899004;37348749;8491179", "class_list": "", "function": "Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes., [RefSeq, PubMed]; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q921T7", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0060384 innervation;GO:0010466 negative regulation of peptidase activity;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K385-1", "uniprot_id": "FRRS1_MOUSE", "mass": 66047.0, "length": 592, "protein_name": "Ferric reductase 1", "gene_name": "Frrs1", "organism": "Mouse", "refseq_name": "ferric reductase 1 precursor", "refseq_ac": "NP_001106950", "gene_names_uniprotkb": "Frrs1; Sdfr2; Sdr2", "gene_names_refseq": "Frrs1; SDR-2; Sdfr2", "protein_names_uniprotkb": "Ferric reductase 1; 1.-.-.-; Ferric-chelate reductase 1; SDR-2; Stromal cell-derived receptor 2", "protein_names_refseq": "ferric reductase 1 precursor; ferric reductase 1; stromal cell derived factor receptor 2; stromal cell-derived receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20321)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14499595;18250455;19349973;21750661;26495903;28011936;30899004;34428180;34678516;8938438", "class_list": "", "function": "Data show that four members of the b561 family of predicted ferric reductases: mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity., [RefSeq, PubMed]; Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells (PubMed:14499595). The electron donor and therefore the reaction mechanism are not known (PubMed:14499595)., [UniProtKB, PubMed]; Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells. The electron donor and therefore the reaction mechanism are not known., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P97301;Q3TJV0;Q3UMF5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016722 oxidoreductase activity, acting on metal ions", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8K385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3R8-1", "uniprot_id": "GBRL1_MOUSE", "mass": 14044.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "Gabarapl1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor-associated protein-like 1", "refseq_ac": "NP_065615", "gene_names_uniprotkb": "Gabarapl1; Apg8l; Atg8l; Gec1; MNCb-0091", "gene_names_refseq": "3110025G09Rik; 9130422N19Rik; Apg8l; Atg8l; GECI; Gabarapl1; MNCb-0091", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein-like 1; GABA(A) receptor-associated protein-like 1; GEC-1; Glandular epithelial cell protein 1", "protein_names_refseq": "GABA(A) receptor-associated protein like 1; GEC-1; gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1; gamma-aminobutyric acid receptor-associated protein-like 1; glandular epithelial cell protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57436); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11414770;14530254;16704426;21750661;26776506;33795848;34338405;37507081;37828378", "class_list": "", "function": "Expression of mouse Atg8L in HEK293 cells led to cleavage of its C-terminus. (Atg8L/Apg8l)and is the fourth modifier of mammalian Atg8 conjugation. (ATG8L/Apg8L), [RefSeq, PubMed]; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG14;Q3TJB9;Q3TXZ5;Q9JJ97", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0031625 ubiquitin protein ligase binding;GO:0008092 cytoskeletal protein binding;GO:0030957 Tat protein binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0000423 mitophagy;GO:0006995 cellular response to nitrogen starvation;GO:0061723 glycophagy", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R3R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32082-1", "uniprot_id": "GHRHR_MOUSE", "mass": 47004.0, "length": 423, "protein_name": "Growth hormone-releasing hormone receptor", "gene_name": "Ghrhr", "organism": "Mouse", "refseq_name": "growth hormone-releasing hormone receptor precursor", "refseq_ac": "NP_001003685", "gene_names_uniprotkb": "Ghrhr; Grfr", "gene_names_refseq": "Ghrfr; Ghrhr; little; lit", "protein_names_uniprotkb": "Growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR; Growth hormone-releasing factor receptor", "protein_names_refseq": "GHRH receptor; GRF receptor; GRFR; growth hormone-releasing factor receptor; growth hormone-releasing hormone receptor precursor", "tax_id": 10090, "disease": "isolated growth hormone deficiency (Disease Ontology:DOID:0060870); isolated growth hormone deficiency type IB (Disease Ontology:DOID:0060874); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (mmu:14602); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1334535;21750661;8391647", "class_list": "", "function": "Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB62", "ec_number_list": "", "go_molecular_function": "GO:0019838 growth factor binding;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P32082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1HCM0-1", "uniprot_id": "FGFP3_MOUSE", "mass": 26217.0, "length": 245, "protein_name": "Fibroblast growth factor-binding protein 3", "gene_name": "Fgfbp3", "organism": "Mouse", "refseq_name": "fibroblast growth factor-binding protein 3 precursor", "refseq_ac": "NP_082539", "gene_names_uniprotkb": "Fgfbp3", "gene_names_refseq": "2610306H15Rik; Fgf-bp3; Fgfbp3", "protein_names_uniprotkb": "Fibroblast growth factor-binding protein 3; FGF-BP3; FGF-binding protein 3; FGFBP-3", "protein_names_refseq": "FGF-binding protein 3; FGFBP-3; fibroblast growth factor-binding protein 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72514); (R-MMU-190377)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20851768;21750661", "class_list": "", "function": "Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability., [UniProtKB, UniProtKB]; These results demonstrate that FGF-BP3 is a potent mediator of anxiety-related behaviors in mice and suggest that distinct pathways regulate emotional behaviors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNS6;Q8CDW7", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0030534 adult behavior;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043117 positive regulation of vascular permeability;GO:0031646 positive regulation of nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1HCM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35846-1", "uniprot_id": "FOLR1_MOUSE", "mass": 29449.0, "length": 255, "protein_name": "Folate receptor alpha", "gene_name": "Folr1", "organism": "Mouse", "refseq_name": "folate receptor alpha precursor", "refseq_ac": "NP_001239481", "gene_names_uniprotkb": "Folr1; Fbp1; Folbp1", "gene_names_refseq": "FBP1; Folbp-1; Folbp1; Folr1", "protein_names_uniprotkb": "Folate receptor alpha; FR-alpha; Folate receptor 1; Folate-binding protein 1", "protein_names_refseq": "FR-alpha; folate receptor 1 (adult); folate receptor alpha precursor; folate-binding protein 1", "tax_id": 10090, "disease": "cerebral folate receptor alpha deficiency (Disease Ontology:DOID:0050719)", "pathway": " (mmu:14275); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6807878)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10216260;10508523;12854656;1429588;15259034;15703271;17286298;1894617;21750661;38519576", "class_list": "", "function": "Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Role of folate receptor alpha in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 8560, "biomarker_type": "", "glycan_count": 12, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9R222", "ec_number_list": "", "go_molecular_function": "GO:0005542 folic acid binding;GO:0061714 folic acid receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0046654 tetrahydrofolate biosynthetic process;GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P35846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05685-1", "uniprot_id": "FOLR2_MOUSE", "mass": 28821.0, "length": 251, "protein_name": "Folate receptor beta", "gene_name": "Folr2", "organism": "Mouse", "refseq_name": "folate receptor beta precursor", "refseq_ac": "NP_001290160", "gene_names_uniprotkb": "Folr2; Fbp2; Folbp2", "gene_names_refseq": "FBP2; FR-P3; FR-beta; Folbp-2; Folbp2; Folr2", "protein_names_uniprotkb": "Folate receptor beta; FR-beta; Folate receptor 2; Folate-binding protein 2", "protein_names_refseq": "folate binding protein 2; folate receptor 2 (fetal); folate receptor beta precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14276); (R-MMU-163125); (R-MMU-196757); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10508523;15703271;1894617;21750661;31219806;31824505;34428180;34995099;8307991", "class_list": "", "function": "(18)F-AzaFol for Detection of Folate Receptor-beta Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study. Publication Status: Online-Only, [RefSeq, PubMed]; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity)., [UniProtKB]; This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]; Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005542 folic acid binding;GO:0061714 folic acid receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHD2-1", "uniprot_id": "GFOD1_MOUSE", "mass": 43286.0, "length": 390, "protein_name": "Glucose-fructose oxidoreductase domain-containing protein 1", "gene_name": "Gfod1", "organism": "Mouse", "refseq_name": "glucose-fructose oxidoreductase domain-containing protein 1 precursor", "refseq_ac": "NP_001028571", "gene_names_uniprotkb": "Gfod1", "gene_names_refseq": "9630032O13; Gfod1", "protein_names_uniprotkb": "Glucose-fructose oxidoreductase domain-containing protein 1", "protein_names_refseq": "glucose-fructose oxidoreductase domain-containing protein 1 precursor; glucose-fructose oxidoreductase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:328232); (R-MMU-9013406)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Probably catalytically inactive enzyme. Does not bind NAD or NADP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EI39", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UHD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WB0-1", "uniprot_id": "FND11_MOUSE", "mass": 37356.0, "length": 326, "protein_name": "Fibronectin type III domain-containing protein 11", "gene_name": "Fndc11", "organism": "Mouse", "refseq_name": "fibronectin type III domain-containing protein 11 isoform b", "refseq_ac": "NP_955016", "gene_names_uniprotkb": "Fndc11; BC051628", "gene_names_refseq": "1700026M20Rik; Fndc11", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 11", "protein_names_refseq": "fibronectin type III domain-containing protein 11 isoform b; fibronectin type III domain-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:332713)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AS01", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80WB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00612-1", "uniprot_id": "G6PD1_MOUSE", "mass": 59263.0, "length": 515, "protein_name": "Glucose-6-phosphate 1-dehydrogenase X", "gene_name": "G6pdx", "organism": "Mouse", "refseq_name": "glucose-6-phosphate 1-dehydrogenase X", "refseq_ac": "NP_032088", "gene_names_uniprotkb": "G6pdx; G6pd-1; G6pd", "gene_names_refseq": "G28A; G6pdx; G6pd; Gpdx", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase X; 1.-.-.-; 1.1.1.49; G6PD", "protein_names_refseq": "glucose-6-phosphate 1-dehydrogenase X", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); favism (Disease Ontology:DOID:13628); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14381); (R-MMU-5628897); (R-MMU-71336)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "12831846;17947660;1874446;21750661;25428506;31219806;31599954;33964586;34428180;35122041;35272030;36835034;37119432;37507081;39276450;8400362;9330624", "class_list": "glycogene", "function": "Brucella induced upregulation of NO promote macrophages glycolysis through the NF-kappaB/G6PD pathway., [RefSeq, PubMed]; Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis., [RefSeq, PubMed]; G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation., [RefSeq, PubMed]; Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of Arginase II. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.-.-.-;1.1.1.49;3.1.1.31;1.1.1.47;1.1.1.363", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0006739 NADP+ metabolic process;GO:0006741 NADP+ biosynthetic process;GO:0043249 erythrocyte maturation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q00612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSM5-1", "uniprot_id": "GAB3_MOUSE", "mass": 67840.0, "length": 595, "protein_name": "GRB2-associated-binding protein 3", "gene_name": "Gab3", "organism": "Mouse", "refseq_name": "GRB2-associated-binding protein 3", "refseq_ac": "NP_853615", "gene_names_uniprotkb": "Gab3", "gene_names_refseq": "5930433H21Rik; Gab3", "protein_names_uniprotkb": "GRB2-associated-binding protein 3; GRB2-associated binder 3; Growth factor receptor bound protein 2-associated protein 3", "protein_names_refseq": "GRB2-associated binder 3; GRB2-associated-binding protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:210710)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11739737;11997510;12640125;16503986;21750661;30936879;31375526", "class_list": "", "function": "Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8(+) T-Cell Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent, [RefSeq, PubMed]; Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. (Gab3 scaffolding protein), [RefSeq, PubMed]; The Gab3 is a key component required for cytokine-mediated NK cell priming and expansion that is essential for antitumor responses and limits trophoblast cell invasion during pregnancy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q684I9;Q8VH53", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0030225 macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BSM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WJ0-1", "uniprot_id": "FRS3_MOUSE", "mass": 53976.0, "length": 492, "protein_name": "Fibroblast growth factor receptor substrate 3", "gene_name": "Frs3", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor substrate 3", "refseq_ac": "NP_659188", "gene_names_uniprotkb": "Frs3; Frs2b", "gene_names_refseq": "4930417B13Rik; Frs2beta; Frs3; Snt2", "protein_names_uniprotkb": "Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FRS2-beta", "protein_names_refseq": "FGFR substrate 3; FRS2-beta; fibroblast growth factor receptor substrate 3; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)", "tax_id": 10090, "disease": "", "pathway": " (mmu:107971); (R-MMU-5654693); (R-MMU-5654700); (R-MMU-5654706); (R-MMU-5654712); (R-MMU-5673001); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10629055;12586769;12688531;16887332;21750661;22517741;22645316;29155277;32848054;34663724;40885482", "class_list": "", "function": "Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2., [UniProtKB]; Data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes, [RefSeq, PubMed]; FRS2 and FRS3, are together required for postnatal brain development. In the hippocampus, FRS2&3 promote dentate gyrus morphogenesis and dentate granule cell (DGC) maturation during developmental neurogenesis. Frs2,3-double mutants have reduced numbers of dendritic branches and spines in DGCs. Double-mutant mice exhibit fewer excitatory synaptic inputs onto DGCs., [RefSeq, PubMed]; The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91WJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50608-1", "uniprot_id": "FMOD_MOUSE", "mass": 43055.0, "length": 376, "protein_name": "Fibromodulin", "gene_name": "Fmod", "organism": "Mouse", "refseq_name": "fibromodulin precursor", "refseq_ac": "NP_067330", "gene_names_uniprotkb": "Fmod", "gene_names_refseq": "FM; Fmod; SLRR2E", "protein_names_uniprotkb": "Fibromodulin; Collagen-binding 59 kDa protein; FM; KSPG fibromodulin; Keratan sulfate proteoglycan fibromodulin", "protein_names_refseq": "KSPG fibromodulin; collagen-binding 59 kDa protein; fibromodulin precursor; keratan sulfate proteoglycan fibromodulin", "tax_id": 10090, "disease": "gingivitis (Disease Ontology:DOID:3087); periodontitis (Disease Ontology:DOID:824); tendinitis (Disease Ontology:DOID:971)", "pathway": " (mmu:14264); (R-MMU-2022854); (R-MMU-2022857)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11311118;21750661;34428180;37149118;38864941;39927985", "class_list": "glycogene", "function": "Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis., [UniProtKB]; Dark pigmentation and related low FMOD expression increase IL-3 and facilitateplasmacytoid dendritic cell maturation., [RefSeq, PubMed]; FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P50608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQE9-1", "uniprot_id": "FWCH2_MOUSE", "mass": 14458.0, "length": 139, "protein_name": "FLYWCH family member 2", "gene_name": "Flywch2", "organism": "Mouse", "refseq_name": "FLYWCH family member 2", "refseq_ac": "NP_084074", "gene_names_uniprotkb": "Flywch2", "gene_names_refseq": "2810417J12Rik; 3010014L17Rik; Flywch2", "protein_names_uniprotkb": "FLYWCH family member 2", "protein_names_refseq": "FLYWCH family member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76917)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3N7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3Q3-1", "uniprot_id": "FOXN4_MOUSE", "mass": 56121.0, "length": 521, "protein_name": "Forkhead box protein N4", "gene_name": "Foxn4", "organism": "Mouse", "refseq_name": "forkhead box protein N4", "refseq_ac": "NP_683737", "gene_names_uniprotkb": "Foxn4", "gene_names_refseq": "Foxn4", "protein_names_uniprotkb": "Forkhead box protein N4", "protein_names_refseq": "forkhead box protein N4", "tax_id": 10090, "disease": "", "pathway": " (mmu:116810)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11520680;15363391;16020526;17728344;21438071;21750661;22323600;23652001", "class_list": "", "function": "Expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain, [RefSeq, PubMed]; Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord., [RefSeq, PubMed]; Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGP0;Q920C0", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K3Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G5E8F4-1", "uniprot_id": "FPGT_MOUSE", "mass": 65362.0, "length": 590, "protein_name": "Fucose-1-phosphate guanylyltransferase", "gene_name": "Fpgt", "organism": "Mouse", "refseq_name": "fucose-1-phosphate guanylyltransferase", "refseq_ac": "NP_083606", "gene_names_uniprotkb": "Fpgt", "gene_names_refseq": "1700016E03Rik; Fpgt", "protein_names_uniprotkb": "Fucose-1-phosphate guanylyltransferase; 2.7.7.30; GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylase", "protein_names_refseq": "GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylase; fucose-1-phosphate guanylyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75540); (R-MMU-6787639)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14686921;21525387;25428506;30779550;34428180", "class_list": "glycogene", "function": "Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:14686921). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable)., [UniProtKB, PubMed]; Cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase, [RefSeq, PubMed]; Data identified Tnni3k, Fpgt and H28 as likely likely candidates for Vms1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TB53;Q712G7;Q8C1A2", "ec_number_list": "2.7.7.30", "go_molecular_function": "GO:0047341 fucose-1-phosphate guanylyltransferase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0042354 L-fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G5E8F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6XQH0-1", "uniprot_id": "G3ST2_MOUSE", "mass": 46909.0, "length": 394, "protein_name": "Galactose-3-O-sulfotransferase 2", "gene_name": "Gal3st2b; Gal3st2", "organism": "Mouse", "refseq_name": "galactose-3-O-sulfotransferase 2", "refseq_ac": "NP_001192178", "gene_names_uniprotkb": "Gal3st2b; Gal3st2; Gm988", "gene_names_refseq": "Gal3ST-2; Gal3st2b; Gal3st2; Gm988; Gm9994", "protein_names_uniprotkb": "Galactose-3-O-sulfotransferase 2; 2.8.2.-; Beta-galactose-3-O-sulfotransferase 2; Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2; Gal3ST-2", "protein_names_refseq": "beta-galactose-3-O-sulfotransferase 2; gal-beta-1, 3-GalNAc 3'-sulfotransferase 2; galactose-3-O-sulfotransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041596)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15926885;21750661", "class_list": "glycogene", "function": "Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-galactosyl residues (PubMed:15926885). Acts preferentially to core 1 (Gal-beta-1,3-GalNAc-alpha-1-R) and type 2 (Gal-beta-1,4-GlcNAc-R) chains (PubMed:15926885). Displays species-dependent substrate specificity (PubMed:15926885). Participates in galactose sulfation and shows substrate preference for structures such as lacto-N-neotetraose (nLc4), and the Gal-beta-1,4-GlcNAc-beta unit in mucin core-2 (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050694 galactose 3-O-sulfotransferase activity;GO:0001733 galactosylceramide sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0051923 sulfation;GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6XQH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08832-1", "uniprot_id": "GALT4_MOUSE", "mass": 66555.0, "length": 578, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 4", "gene_name": "Galnt4", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 4", "refseq_ac": "NP_056552", "gene_names_uniprotkb": "Galnt4", "gene_names_refseq": "Galnt4", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 4; 2.4.1.41; GalNAc-T4; Polypeptide GalNAc transferase 4; Protein-UDP acetylgalactosaminyltransferase 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; pp-GaNTase 4", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4; galNAc-T4; polypeptide GalNAc transferase 4; polypeptide N-acetylgalactosaminyltransferase 4; pp-GaNTase 4; ppGaNTase-T4; protein-UDP acetylgalactosaminyltransferase 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14426); (R-MMU-913709)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "25428506;26495903;27965094;31209405;34428180;34662438;34974060;9153242", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b., [UniProtKB, PubMed]; GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis., [RefSeq, PubMed]; N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization., [RefSeq, PubMed]; The ppGalNAc-T4 was highly expressed in MC3T3-E1 cells during osteogenesis for the first time; ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoforms play in regulating osteogenesis in vitro, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U681", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.9, "record_id": "O08832-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35409-1", "uniprot_id": "FOLH1_MOUSE", "mass": 84574.0, "length": 752, "protein_name": "Glutamate carboxypeptidase 2", "gene_name": "Folh1", "organism": "Mouse", "refseq_name": "glutamate carboxypeptidase 2 isoform 2", "refseq_ac": "NP_001153178", "gene_names_uniprotkb": "Folh1; Mopsm; Naalad1", "gene_names_refseq": "Folh1; GCP2; mopsm", "protein_names_uniprotkb": "Glutamate carboxypeptidase 2; 3.4.17.21; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen homolog; Pteroylpoly-gamma-glutamate carboxypeptidase; mGCP", "protein_names_refseq": "FGCP; GCPII; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxypeptidase 2 isoform 2; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; mGCP; membrane glutamate carboxypeptidase; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase", "tax_id": 10090, "disease": "cerebral infarction (Disease Ontology:DOID:3526); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:53320); (R-MMU-8963693)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11210180;19267351;30899004;33300544;37349952;38377674;39000003", "class_list": "", "function": "Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC., [UniProtKB]; Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long-term benefits in mice with traumatic brain injury., [RefSeq, PubMed]; GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate., [UniProtKB]; Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDM5;Q9DCC2", "ec_number_list": "3.4.17.21", "go_molecular_function": "GO:1904492 Ac-Asp-Glu binding;GO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0098829 intestinal folate absorption;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0030163 protein catabolic process;GO:0006760 folic acid-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "O35409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70421-1", "uniprot_id": "FZD1_MOUSE", "mass": 71127.0, "length": 642, "protein_name": "Frizzled-1", "gene_name": "Fzd1", "organism": "Mouse", "refseq_name": "frizzled-1 precursor", "refseq_ac": "NP_067432", "gene_names_uniprotkb": "Fzd1", "gene_names_refseq": "FZ-1; Fz1; Fzd1", "protein_names_uniprotkb": "Frizzled-1; Fz-1; mFz1", "protein_names_refseq": "frizzled homolog 1; frizzled-1 precursor; frizzled-1; mFz1", "tax_id": 10090, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (mmu:14362); (R-MMU-4086400); (R-MMU-4608870); (R-MMU-4641262)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11334716;11861511;15923619;26740625;30084848;30779550;31599954", "class_list": "", "function": "Fz-1 is expressed at distinct stages of follicular development., [RefSeq, PubMed]; Receptor for Wnt proteins (PubMed:15923619). Activated by WNT7B (PubMed:15923619). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:15923619). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08974;Q7TS82", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007267 cell-cell signaling;GO:0010976 positive regulation of neuron projection development;GO:0030855 epithelial cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70421-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88470-1", "uniprot_id": "FOXL2_MOUSE", "mass": 38887.0, "length": 375, "protein_name": "Forkhead box protein L2", "gene_name": "Foxl2", "organism": "Mouse", "refseq_name": "forkhead box protein L2", "refseq_ac": "NP_036150", "gene_names_uniprotkb": "Foxl2; Pfrk", "gene_names_refseq": "BPES; Foxl2; P-Frk; PINTO; Pfrk", "protein_names_uniprotkb": "Forkhead box protein L2; P-Frk; Pituitary forkhead factor", "protein_names_refseq": "forkhead box protein L2; pituitary forkhead factor; putative transcription factor foxl2", "tax_id": 10090, "disease": "primary ovarian insufficiency 3 (Disease Ontology:DOID:0080860); blepharophimosis, ptosis, and epicanthus inversus syndrome (Disease Ontology:DOID:14778); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); granulosa cell tumor (Disease Ontology:DOID:2999); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:26927); (R-MMU-3232118)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12471206;12810580;15059956;15944199;16153597;19106105;19797124;20005806;9620855", "class_list": "", "function": "FOXL2 is a highly conserved early regulator of vertebrate ovarian development., [RefSeq, PubMed]; Molecular evolution and expression of FOXL2, [RefSeq, PubMed]; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3X9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090543 Flemming body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88621-1", "uniprot_id": "FOXH1_MOUSE", "mass": 44001.0, "length": 401, "protein_name": "Forkhead box protein H1", "gene_name": "Foxh1", "organism": "Mouse", "refseq_name": "forkhead box protein H1", "refseq_ac": "NP_032015", "gene_names_uniprotkb": "Foxh1; Fast1; Fast2", "gene_names_refseq": "Fast1; Fast2; Foxh1; fast-1; fast-2", "protein_names_uniprotkb": "Forkhead box protein H1; Fast-1; Fast-2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2", "protein_names_refseq": "FAST1 transcription factor; forkhead activin signal transducer 1; forkhead activin signal transducer 2; forkhead box protein H1", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); agnathia-otocephaly complex (Disease Ontology:DOID:0060341)", "pathway": " (mmu:14106)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10349617;27432806;31068365;35820727;9702197;9858566", "class_list": "", "function": "FOXH1 was identified as a critical mediator of mutant p53 function that binds to and regulates stem cell-associated genes and transcriptional programs in the context of mouse model of acute myeloid leukemia., [RefSeq, PubMed]; That FAST2 is expressed in a cell-specific manner during ovarian follicle development, [RefSeq, PubMed]; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZL5;Q9R241", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032444 activin responsive factor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01864-1", "uniprot_id": "GCAB_MOUSE", "mass": 36596.0, "length": 335, "protein_name": "Ig gamma-2A chain C region secreted form", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-2A chain C region secreted form; B allele", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "17330941;25605945;34428180;35820727;35984892;36288343;6170065;6794027", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01865-1", "uniprot_id": "GCAM_MOUSE", "mass": 43949.0, "length": 398, "protein_name": "Immunoglobulin heavy constant gamma 2A", "gene_name": "Ighg2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighg2a; Igh-1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant gamma 2A; Ig gamma-2A chain C region, membrane-bound form", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "17330941;2513486;34428180;35984892;36210013;6262729;6283537", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005771 multivesicular body;GO:0042571 immunoglobulin complex, circulating;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0019731 antibacterial humoral response;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0009617 response to bacterium;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P01865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05524-1", "uniprot_id": "FGF3_MOUSE", "mass": 27214.0, "length": 245, "protein_name": "Fibroblast growth factor 3", "gene_name": "Fgf3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Fgf3; Fgf-3; Int-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor 3; FGF-3; HBGF-3; Heparin-binding growth factor 3; Proto-oncogene Int-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (R-MMU-109704); (R-MMU-1257604); (R-MMU-190370); (R-MMU-190377); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 18, "publication_count": 5, "publication_id_list": "1964688;21750661;2406607;2841106;3013624", "class_list": "glycogene", "function": "Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61736", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001759 organ induction;GO:0048752 semicircular canal morphogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0048538 thymus development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09528-1", "uniprot_id": "FRIH_MOUSE", "mass": 21067.0, "length": 182, "protein_name": "Ferritin heavy chain", "gene_name": "Fth1", "organism": "Mouse", "refseq_name": "ferritin heavy chain", "refseq_ac": "NP_034369", "gene_names_uniprotkb": "Fth1; Fth", "gene_names_refseq": "FHC; Fth1; Fth; HFt; MFH", "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1; Ferritin H subunit; Hft", "protein_names_refseq": "H-ferritin; ferritin H subunit; ferritin heavy chain 1; ferritin heavy chain", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); hemochromatosis type 5 (Disease Ontology:DOID:0111031); candidiasis (Disease Ontology:DOID:1508); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14319); (R-MMU-432722); (R-MMU-6798695); (R-MMU-917937)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10652280;11468145;19154717;21750661;2258056;25327288;26495903;2708374;2798146;30102720;3194211;32647824;33725478;33984504;3410854;34428180;35233453;35984892;36288343;36578473;37258702;37453647;37507081;39277607", "class_list": "", "function": "Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (PubMed:19154717). Mediates iron uptake in capsule cells of the developing kidney (PubMed:19154717). Degraded to release iron upon autophagy activation by nutrient starvation (PubMed:25327288)., [UniProtKB, PubMed, UniProtKB, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI44", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;1.16.3.1;3.4.24.34;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.4.21.4;3.6.4.10;3.4.21.-;3.2.1.17;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.1.3.48;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;1.11.1.27;1.11.1.9;1.16.3.4;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;1.8.3.2;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;3.2.1.14;5.4.2.11;5.4.2.4;2.4.1.1;3.5.1.3;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation;GO:0051259 protein complex oligomerization;GO:0006879 intracellular iron ion homeostasis;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P09528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12804-1", "uniprot_id": "FGL2_MOUSE", "mass": 48951.0, "length": 432, "protein_name": "Fibroleukin", "gene_name": "Fgl2", "organism": "Mouse", "refseq_name": "fibroleukin precursor", "refseq_ac": "NP_032039", "gene_names_uniprotkb": "Fgl2; Fiblp", "gene_names_refseq": "Fgl2; musfiblp", "protein_names_uniprotkb": "Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Prothrombinase", "protein_names_refseq": "associated with MHV-3 induced prothrombinase activity; cytotoxic T-lymphocyte-specific protein; fibroleukin precursor; fibroleukin", "tax_id": 10090, "disease": "autoimmune glomerulonephritis (Disease Ontology:DOID:0040094)", "pathway": " (mmu:14190); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10187767;11465105;26495903;27802388;28011936;28935714;34428180;3550794;35984892;37734200;38056898;38191799;38902261;7609073", "class_list": "", "function": "CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB. Publication Status: Online-Only, [RefSeq, PubMed]; Converts prothrombin to thrombin., [UniProtKB]; FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models. Publication Status: Online-Only, [RefSeq, PubMed]; Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007596 blood coagulation;GO:0031640 killing of cells of another organism;GO:0050687 negative regulation of defense response to virus;GO:0002605 negative regulation of dendritic cell antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P12804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15655-1", "uniprot_id": "FGF2_MOUSE", "mass": 17153.0, "length": 154, "protein_name": "Fibroblast growth factor 2", "gene_name": "Fgf2", "organism": "Mouse", "refseq_name": "fibroblast growth factor 2", "refseq_ac": "NP_032032", "gene_names_uniprotkb": "Fgf2; Fgf-2", "gene_names_refseq": "Fgf-2; Fgf2a; Fgf2; Fgfb; bFGF", "protein_names_uniprotkb": "Fibroblast growth factor 2; Basic fibroblast growth factor; FGF-2; HBGF-2; Heparin-binding growth factor 2; bFGF", "protein_names_refseq": "HBGF-2; basic fibroblast growth factor; fibroblast growth factor 2a; fibroblast growth factor 2; heparin-binding growth factor 2", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); bone disease (Disease Ontology:DOID:0080001); COVID-19 (Disease Ontology:DOID:0080600); Parkinsonism (Disease Ontology:DOID:0080855); multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); corneal neovascularization (Disease Ontology:DOID:11382); leiomyoma (Disease Ontology:DOID:127); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); transitional cell carcinoma (Disease Ontology:DOID:2671); dermatitis (Disease Ontology:DOID:2723); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); bladder disease (Disease Ontology:DOID:365); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); chronic ulcer of skin (Disease Ontology:DOID:8549); decubitus ulcer (Disease Ontology:DOID:8717); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); biliary tract disease (Disease Ontology:DOID:9741); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (mmu:14173); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190370); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-190377); (R-MMU-3000170); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5658623); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-9839397)", "pathway_count": 35, "publication_count": 6, "publication_id_list": "20851768;2318343;28323137;38185886;38762650;9178765", "class_list": "glycogene", "function": "A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice., [RefSeq, PubMed]; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity)., [UniProtKB, UniProtKB]; MiR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0046668 regulation of retinal cell programmed cell death;GO:0001759 organ induction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0009792 embryo development ending in birth or egg hatching", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P15655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21658-1", "uniprot_id": "FGF6_MOUSE", "mass": 22798.0, "length": 208, "protein_name": "Fibroblast growth factor 6", "gene_name": "Fgf6", "organism": "Mouse", "refseq_name": "fibroblast growth factor 6 precursor", "refseq_ac": "NP_034334", "gene_names_uniprotkb": "Fgf6; Fgf-6; Hstf2", "gene_names_refseq": "Fgf-6; Fgf6; Fgf7b; HSTF-2", "protein_names_uniprotkb": "Fibroblast growth factor 6; FGF-6; HBGF-6; HST-2; HSTF-2; Heparin secretory-transforming protein 2; Heparin-binding growth factor 6", "protein_names_refseq": "HBGF-6; HST-2; fibroblast growth factor 6 precursor; fibroblast growth factor 7b; heparin secretory-transforming protein 2; heparin-binding growth factor 6", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:14177); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190373); (R-MMU-190375); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 24, "publication_count": 4, "publication_id_list": "1477139;2193291;34491915;34739848", "class_list": "glycogene", "function": "Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool., [RefSeq, PubMed]; Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration., [UniProtKB]; Skeletal muscle-targeted delivery of Fgf6 protects mice from diet-induced obesity and insulin resistance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0042383 sarcolemma", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21658-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23336-1", "uniprot_id": "GGTA1_MOUSE", "mass": 46475.0, "length": 394, "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase", "gene_name": "Ggta1", "organism": "Mouse", "refseq_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2", "refseq_ac": "NP_001139293", "gene_names_uniprotkb": "Ggta1; Ggta-1", "gene_names_refseq": "GALT; Gal; Ggta-1; Ggta1; Ggta; alpha Gal; alpha3GalT", "protein_names_uniprotkb": "N-acetyllactosaminide alpha-1,3-galactosyltransferase; 2.4.1.87; Galactosyltransferase; UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase", "protein_names_refseq": "N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 2; N-acetyllactosaminide alpha-1,3-galactosyltransferase; UDP-galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; glycoprotein alpha galactosyl transferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14594)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11267031;12626403;1544928;21750661;2510162;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3)., [UniProtKB, PubMed]; This gene encodes a member of the galactosyltransferase family of intracellular, membrane-bound enzymes that are involved in the biosynthesis of glycoproteins and glycolipids. The encoded protein catalyzes the transfer of galactose from UDP-galactose to N-acetyllactosamine in an alpha(1,3) linkage to form galactose alpha(1,3)-galactose. Mice lacking the encoded protein develop cortical cataracts. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91V22", "ec_number_list": "2.4.1.87", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 43, "hit_score": 1.0, "record_id": "P23336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33766-1", "uniprot_id": "FPR1_MOUSE", "mass": 40327.0, "length": 364, "protein_name": "N-formyl peptide receptor 1", "gene_name": "Fpr1", "organism": "Mouse", "refseq_name": "N-formyl peptide receptor 1", "refseq_ac": "NP_038549", "gene_names_uniprotkb": "Fpr1", "gene_names_refseq": "FPR; Fpr1; LXA4R; fMLF-R", "protein_names_uniprotkb": "N-formyl peptide receptor 1; N-formylpeptide chemoattractant receptor; fMLP receptor; fMet-Leu-Phe receptor", "protein_names_refseq": "N-formyl peptide receptor 1; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor; fMLP receptor; fMet-Leu-Phe receptor; lipoxin A4 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14293); (R-MMU-418594); (R-MMU-444473); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "17084101;18606697;19497865;20947763;25605714;26516201;31534221;37979162;38508232;8244972;9989980", "class_list": "", "function": "(Microbial infection) Used by Y. pestis as a receptor on immune cells. Upon infection, Y. pestis releases N-formyl peptides that activate FPR1-mediated immune signaling and chemotaxis. This leads to Y. pestis docking on FPR1 via the lcrV needle cap protein of its type III secretion system (T3SS) followed by the delivery of effector proteins into host immune cells, ultimately triggering immune cell apoptosis., [UniProtKB, PubMed]; Formylpeptide receptor 1 contributes to epidermal barrier dysfunction-induced skin inflammation through NOD-like receptor C4-dependent keratinocyte activation., [RefSeq, PubMed]; Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing., [RefSeq, PubMed]; Pattern recognition G protein-coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis (PubMed:18606697, PubMed:25605714, PubMed:8244972, PubMed:9989980). Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx (By similarity) (PubMed:8244972, PubMed:9989980). Displays two affinity states for peptide agonists, low and high, likely accounting for selective signaling of myeloid cell functions at different phases of the inflammatory response. Subnanomolar concentrations of peptide agonists induce myeloid cell chemotaxis, whereas micromolar concentrations trigger degranulation and superoxide production (By similarity). May recognize a myriad of bacterial signal peptides indicative of an evolutionary conserved detection mechanism in host defense against bacterial infection. Triggers bactericidal functions of neutrophils and phagocytes in response to N-formyl-Met-Leu-Phe (fMLF) which is part of the signal peptide sequences of hundreds distinct bacterial strains (PubMed:18606697, PubMed:25605714, PubMed:9989980). In the homeostatic wound healing response to tissue injury, senses 'necrotaxis' DAMP-type signals released in the form of mitochondria-derived N-formylated peptides and guides neutrophil trafficking toward necrotic cells within the injury site (PubMed:20947763). In the context of antitumor immunity, interacts with ANXA1 and guides dendritic cell positioning in close proximity to necrotic tumor cells, allowing for tumor-associated antigen uptake and cross-presentation to T cells (PubMed:26516201). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing reactive oxygen species (ROS) release (By similarity). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity). Beyond canonical N-terminal formylated peptide agonists, can also be activated by C-terminal amidated peptides, which appear to all share a tripartite structure motif oriented around a carboxyl group (PubMed:25605714). Differential signaling is also defined by receptor oligomerization state. Pro-resolving ligands, such as lipoxin A4 or ANXA1, induce the formation of FPR1:FPR2 heterodimers triggering proapoptotic JNK pathway in neutrophils (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV01", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0005124 scavenger receptor binding;GO:0050786 RAGE receptor binding;GO:0004930 G protein-coupled receptor activity;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P33766-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47212-1", "uniprot_id": "GALA_MOUSE", "mass": 13471.0, "length": 124, "protein_name": "Galanin peptides", "gene_name": "Gal", "organism": "Mouse", "refseq_name": "galanin peptides isoform 1 preproprotein", "refseq_ac": "NP_034383", "gene_names_uniprotkb": "Gal; Galn", "gene_names_refseq": "Galn; Gal", "protein_names_uniprotkb": "Galanin peptides", "protein_names_refseq": "galanin peptides isoform 1 preproprotein; galanin peptides", "tax_id": 10090, "disease": "familial temporal lobe epilepsy 8 (Disease Ontology:DOID:0060754); hypertension (Disease Ontology:DOID:10763); mononeuropathy (Disease Ontology:DOID:1188); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14419); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;8614559;8982069", "class_list": "", "function": "Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3 (By similarity). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a neuroendocrine peptide that is principally produced by a subpopulation of lactotrophs in the pituitary gland. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Mice lacking the encoded protein fail to lactate sufficiently due to abnormalities in the expression of prolactin and lactotroph proliferation, exhibit attenuated chronic neuropathic pain and developmental deficits in the dorsal root ganglion neurons. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature proteins. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031763 galanin receptor binding;GO:0004966 galanin receptor activity;GO:0031764 type 1 galanin receptor binding;GO:0031765 type 2 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0043025 neuronal cell body;GO:0005576 extracellular region", "go_biological_process": "GO:0060746 parental behavior;GO:0031943 regulation of glucocorticoid metabolic process;GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56479-1", "uniprot_id": "GALR1_MOUSE", "mass": 39114.0, "length": 348, "protein_name": "Galanin receptor type 1", "gene_name": "Galr1", "organism": "Mouse", "refseq_name": "galanin receptor type 1", "refseq_ac": "NP_032108", "gene_names_uniprotkb": "Galr1; Galnr1; Galnr", "gene_names_refseq": "Galnr1; Galr1", "protein_names_uniprotkb": "Galanin receptor type 1; GAL1-R; GALR-1", "protein_names_refseq": "GAL1-R; GALR-1; galanin receptor type 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); opioid abuse (Disease Ontology:DOID:11206); opiate dependence (Disease Ontology:DOID:2559)", "pathway": " (mmu:14427); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "31953035;34370270;9271210;9367674", "class_list": "", "function": "Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity., [UniProtKB, UniProtKB, PubMed]; These data demonstrate that Galanin (Gal) contributes not only to cholangiocyte proliferation but also to liver fibrogenesis via the coordinate activation of GalR1 in cholangiocytes and GalR2 in hepatic stellate cells (HSCs)., [RefSeq, PubMed]; Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004966 galanin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56479-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56481-1", "uniprot_id": "GASR_MOUSE", "mass": 49172.0, "length": 453, "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "Cckbr", "organism": "Mouse", "refseq_name": "gastrin/cholecystokinin type B receptor isoform 1", "refseq_ac": "NP_031653", "gene_names_uniprotkb": "Cckbr", "gene_names_refseq": "CCK-BR; CCK2-R; CCK2R; CCKR-2; Cckbr", "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; CCK2-R; Cholecystokinin-2 receptor", "protein_names_refseq": "CCK-B receptor; CCK-B/gastrin receptor; CCK2/gastrin receptor; cholecystokinin-2 receptor; gastrin/cholecystokinin type B receptor isoform 1; gastrin/cholecystokinin type B receptor", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); toxic shock syndrome (Disease Ontology:DOID:14115); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); panic disorder (Disease Ontology:DOID:594)", "pathway": " (mmu:12426); (R-MMU-375276); (R-MMU-416476); (R-MMU-881907)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10860839;37787155;38252699;39721589;39950948", "class_list": "", "function": "CCK2-receptor deficiency impairs immune balance by influencing CD4[+] T cells development by inhibiting cortical-thymic-epithelial-cells., [RefSeq, PubMed]; Implicating the cholecystokinin B receptor in liver stem cell oncogenesis., [RefSeq, PubMed]; Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (By similarity). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (PubMed:39950948). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (PubMed:39721589)., [UniProtKB, UniProtKB, PubMed, PubMed]; This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008188 neuropeptide receptor activity;GO:0015054 gastrin receptor activity;GO:0004951 cholecystokinin receptor activity;GO:0031741 type B gastrin/cholecystokinin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59266-1", "uniprot_id": "FITM2_MOUSE", "mass": 30016.0, "length": 262, "protein_name": "Acyl-coenzyme A diphosphatase FITM2", "gene_name": "Fitm2", "organism": "Mouse", "refseq_name": "acyl-coenzyme A diphosphatase FITM2", "refseq_ac": "NP_775573", "gene_names_uniprotkb": "Fitm2; Fit2", "gene_names_refseq": "D930001I22Rik; Fit2; Fitm2", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase FITM2; 3.6.1.-; Fat storage-inducing transmembrane protein 2; Fat-inducing protein 2", "protein_names_refseq": "acyl-coenzyme A diphosphatase FITM2; fat-inducing protein 2; fat-inducing transcript 2", "tax_id": 10090, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:228859); (R-MMU-8964572)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18160536;20520733;22002063;22106267;26504167;30923760;31219806;35254894;36805337", "class_list": "", "function": "Destabilization of beta Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes., [RefSeq, PubMed]; FIT1 and FIT2 are endoplasmic reticulum resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver., [RefSeq, PubMed]; FIT2 expression in skeletal muscle plays an unexpected function in regulating muscle energy metabolism and indicates an important role for lipid droplet formation in this process, [RefSeq, PubMed]; FIT2 is a 6 transmembrane domain-containing protein whose conformation likely regulates its activity in mediating lipid droplet formation. Publication Status: Online-Only, [RefSeq, PubMed]; Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:18160536, PubMed:26504167). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity) (PubMed:22106267). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]; Findings indicate that lipid droplet (LD)produced by storage-inducing transmembrane proteins 2 (FIT2) were approximately 80% larger than storage-inducing transmembrane proteins 1 (FIT1)., [RefSeq, PubMed]; Fitm2 is required for ER homeostasis and normal function of murine liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHX3;Q5BKP7", "ec_number_list": "3.6.1.-;3.6.1.77", "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0055088 lipid homeostasis;GO:0007010 cytoskeleton organization;GO:0045444 fat cell differentiation;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P59266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61953-1", "uniprot_id": "GBG11_MOUSE", "mass": 8481.0, "length": 73, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "gene_name": "Gng11", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "refseq_ac": "NP_079607", "gene_names_uniprotkb": "Gng11; Gngt11", "gene_names_refseq": "0610037B21Rik; Gng11; Hg3h1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; heterotrimeric guanine nucleotide-binding protein 3h1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:66066); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50152;Q4QRN2", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63080-1", "uniprot_id": "GBRB3_MOUSE", "mass": 54166.0, "length": 473, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3", "gene_name": "Gabrb3", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-3 isoform a precursor", "refseq_ac": "NP_032097", "gene_names_uniprotkb": "Gabrb3; Gabrb-3", "gene_names_refseq": "A230092K12Rik; Cp1; Gabrb-3; Gabrb3; beta3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor subunit beta-3; GABAAR subunit beta-3", "protein_names_refseq": "GABA(A) receptor subunit beta-3; GABAAR subunit beta-3; cleft palate 1; gamma-aminobutyric acid (GABA) A receptor, subunit beta 3; gamma-aminobutyric acid receptor subunit beta-3 isoform a precursor; gamma-aminobutyric acid receptor subunit beta-3", "tax_id": 10090, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 43 (Disease Ontology:DOID:0080447); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14402); (R-MMU-977443)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10670447;21750661;27129275;28978485;30899004;31219806;33300544;7893750;9108119", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:9108119). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:9108119). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:9108119). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs containing alpha-1, beta-3 and epsilon subunits may permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). Plays an important role in somatosensation and in the production of antinociception (PubMed:10670447)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P15433;Q3UHR3", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0035612 AP-2 adaptor complex binding;GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0001964 startle response;GO:0050975 sensory perception of touch;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63080-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70213-1", "uniprot_id": "FV1_MOUSE", "mass": 51997.0, "length": 459, "protein_name": "Friend virus susceptibility protein 1", "gene_name": "Fv1", "organism": "Mouse", "refseq_name": "Friend virus susceptibility protein 1", "refseq_ac": "NP_034374", "gene_names_uniprotkb": "Fv1", "gene_names_refseq": "Fv-1; Fv1d; Fv1; Rv-1; Rv1", "protein_names_uniprotkb": "Friend virus susceptibility protein 1", "protein_names_refseq": "Friend virus susceptibility protein 1; Fv1 gammaretrovirus restriction factor; Fv1 restriction factor; Rauscher leukemia virus susceptibility 1; retrovirus restriction protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14349)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16474118;25605945;27342974;30224488;34428180;34578445;8752279", "class_list": "", "function": "Data indicate that for some but not all Fv1 proteins, gain of restriction activities could be achieved by increasing the expression level of Fv1; however such a concentration dependent effect is not seen with most Fv1s and cannot explain the recently reported activities against non-MLVs Publication Status: Online-Only, [RefSeq, PubMed]; Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors. Publication Status: Online-Only, [RefSeq, PubMed]; Regions of Fv1 adapt cooperatively, highlighting its preference for repeated structures and suggesting that this functionally constrained aspect of the retroviral capsid lattice presents a common target in the evolution of intrinsic immunity., [RefSeq, PubMed]; Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70214", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0051607 defense response to virus;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70419-1", "uniprot_id": "GALT3_MOUSE", "mass": 72932.0, "length": 633, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 3", "gene_name": "Galnt3", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 3", "refseq_ac": "NP_056551", "gene_names_uniprotkb": "Galnt3", "gene_names_refseq": "Galnt3", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 3; 2.4.1.41; GalNAc-T3; Polypeptide GalNAc transferase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3; galNAc-T3; polypeptide GalNAc transferase 3; polypeptide N-acetylgalactosaminyltransferase 3; pp-GaNTase 3; ppGaNTase-T3; protein-UDP acetylgalactosaminyltransferase 3", "tax_id": 10090, "disease": "hyperphosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0111063)", "pathway": " (mmu:14425); (R-MMU-190372); (R-MMU-913709)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19213845;34203471;36162588;36473594;39098533;8912633", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8912633). Has activity toward HIV envelope glycoprotein gp120 (By similarity). Has activity towards EA2, MUC2 and MUC5 (PubMed:8912633). Probably glycosylates fibronectin in vivo (By similarity). Glycosylates FGF23 (By similarity)., [UniProtKB, PubMed, UniProtKB]; GALNT3 protects against phosphate-induced calcification in vascular smooth muscle cells by enhancing active FGF23 and inhibiting the wnt/beta-catenin signaling pathway. Erratum:[Cell Signal. 2025 Aug;132:111853. doi: 10.1016/j.cellsig.2025.111853. PMID: 40348615], [RefSeq, PubMed]; GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells., [RefSeq, PubMed]; Galnt3-deficient mice have a biochemical phenotype of tumoral calcinosis and provide in vivo evidence that Galnt3 plays an essential role in proper secretion of Fgf23 in mice., [RefSeq, PubMed]; In vivo mapping of the mouse Galnt3-specific O-glycoproteome., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXL2;Q80V55", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006493 protein O-linked glycosylation;GO:0006915 apoptotic process;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 7434, "hit_score": 0.7, "record_id": "P70419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82976-1", "uniprot_id": "GBX1_MOUSE", "mass": 43710.0, "length": 418, "protein_name": "Homeobox protein GBX-1", "gene_name": "Gbx1", "organism": "Mouse", "refseq_name": "homeobox protein GBX-1", "refseq_ac": "NP_056554", "gene_names_uniprotkb": "Gbx1", "gene_names_refseq": "Gbx-1; Gbx1", "protein_names_uniprotkb": "Homeobox protein GBX-1; Gastrulation and brain-specific homeobox protein 1", "protein_names_refseq": "gastrulation and brain-specific homeobox protein 1; homeobox protein GBX-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231044)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11801365;12799077;14745958;1720547;40021952", "class_list": "", "function": "Combined expression of Lhx7 and Gbx1 plays a role in the development of the cholinergic system of the basal forebrain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGW5", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007628 adult walking behavior;GO:0021522 spinal cord motor neuron differentiation;GO:0048663 neuron fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P82976-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VAX3-1", "uniprot_id": "FS2P1_MOUSE", "mass": 57082.0, "length": 487, "protein_name": "Fatty acid desaturase 2-like protein FADS2B", "gene_name": "Fads2b", "organism": "Mouse", "refseq_name": "fatty acid desaturase 2-like protein FADS2B", "refseq_ac": "NP_001075133", "gene_names_uniprotkb": "Fads2b", "gene_names_refseq": "4833423E24Rik; Fads2b; Fads2p1; Gm113", "protein_names_uniprotkb": "Fatty acid desaturase 2-like protein FADS2B; Fatty acid desaturase 2B, pseudogene", "protein_names_refseq": "fatty acid desaturase 2-like protein FADS2B; fatty acid desaturase 2-like protein FADS2P1; fatty acid desaturase 2B, pseudogene", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:228151)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VAX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3I5G5-1", "uniprot_id": "FOXI2_MOUSE", "mass": 32784.0, "length": 311, "protein_name": "Forkhead box protein I2", "gene_name": "Foxi2", "organism": "Mouse", "refseq_name": "forkhead box protein I2", "refseq_ac": "NP_899016", "gene_names_uniprotkb": "Foxi2", "gene_names_refseq": "B130055A05Rik; Foxi2", "protein_names_uniprotkb": "Forkhead box protein I2", "protein_names_refseq": "forkhead box protein I2", "tax_id": 10090, "disease": "", "pathway": " (mmu:270004)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15376323;16289364;35856496", "class_list": "", "function": "Examined the expression patterns of the Foxi class genes from embryonic day 6.5 to 10.5; Foxi2 is expressed throughout the cranial ectoderm adjacent to the neural plate from the 4-somite stage, later becoming excluded from the otic placode, [RefSeq, PubMed]; Forkhead Box i2 Transcription Factor Regulates Systemic Energy Metabolism Via Neuropeptide AgRP., [RefSeq, PubMed]; Possible transcriptional activator., [UniProtKB]; We describe the cloning and analysis of the murine Foxi2 gene, coding for a putative 311 amino acid protein, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIK9", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3I5G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TT99-1", "uniprot_id": "GDE6_MOUSE", "mass": 73220.0, "length": 632, "protein_name": "Glycerophosphodiester phosphodiesterase 6", "gene_name": "Gdpd4", "organism": "Mouse", "refseq_name": "glycerophosphodiester phosphodiesterase domain-containing protein 4", "refseq_ac": "NP_808364", "gene_names_uniprotkb": "Gdpd4; Gde6", "gene_names_refseq": "4921513O04; Gdpd4", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 6; 3.1.4.-; Glycerophosphodiester phosphodiesterase domain-containing protein 4", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 6; glycerophosphodiester phosphodiesterase domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:233537)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15276213", "class_list": "", "function": "Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of TRABD2A and TRABD2B, releasing them from the plasma membrane. The release in the extracellular space inactivates these metalloproteases involved in the negative regulation of Wnt signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BI25", "ec_number_list": "3.1.4.-;3.1.4.2;3.1.4.43", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TT99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UM89-1", "uniprot_id": "FOXR2_MOUSE", "mass": 35036.0, "length": 302, "protein_name": "Forkhead box protein R2", "gene_name": "Foxr2", "organism": "Mouse", "refseq_name": "forkhead box protein R2", "refseq_ac": "NP_001030066", "gene_names_uniprotkb": "Foxr2; Foxn6", "gene_names_refseq": "EG436240; Foxn6; Foxr2", "protein_names_uniprotkb": "Forkhead box protein R2; Forkhead box protein N6", "protein_names_refseq": "forkhead box protein N6; forkhead box protein R2", "tax_id": 10090, "disease": "", "pathway": " (mmu:436240)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15202009;30976792", "class_list": "", "function": "FOXN6 gene was identified within genome sequence RP23-180D16 (FOXN6), [RefSeq, PubMed]; Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AG72;B2RXE0", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UM89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMF9-1", "uniprot_id": "FAXC_MOUSE", "mass": 46811.0, "length": 409, "protein_name": "Failed axon connections homolog", "gene_name": "Faxc", "organism": "Mouse", "refseq_name": "failed axon connections homolog", "refseq_ac": "NP_780443", "gene_names_uniprotkb": "Faxc", "gene_names_refseq": "6230409E13Rik; Faxc", "protein_names_uniprotkb": "Failed axon connections homolog", "protein_names_refseq": "failed axon connections homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76132)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "May play a role in axonal development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UMF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60634-1", "uniprot_id": "FLOT2_MOUSE", "mass": 47038.0, "length": 428, "protein_name": "Flotillin-2", "gene_name": "Flot2", "organism": "Mouse", "refseq_name": "flotillin-2 isoform 1", "refseq_ac": "NP_001035493", "gene_names_uniprotkb": "Flot2; Esa1; M17s1", "gene_names_refseq": "Esa; Flot2; reggie-2", "protein_names_uniprotkb": "Flotillin-2; ESA; Epidermal surface antigen; Membrane component chromosome 17 surface marker 1 homolog", "protein_names_refseq": "epidermal surface antigen; flotillin-2 isoform 1; membrane component chromosome 17 surface marker 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:14252); (R-MMU-5213460); (R-MMU-5675482); (R-MMU-8849932); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9696264); (R-MMU-9696273)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "10212252;21750661;22081607;26495903;33300544;36470425;37688314;37828378;7557989;9153235", "class_list": "", "function": "Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock., [RefSeq, PubMed]; Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SS82;Q6NS75", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:1903905 positive regulation of establishment of T cell polarity;GO:0007155 cell adhesion;GO:0010629 negative regulation of gene expression;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q60634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61239-1", "uniprot_id": "FNTA_MOUSE", "mass": 44013.0, "length": 377, "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "Fnta", "organism": "Mouse", "refseq_name": "protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "refseq_ac": "NP_032059", "gene_names_uniprotkb": "Fnta", "gene_names_refseq": "FTA; Fnta", "protein_names_uniprotkb": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; 2.5.1.58; 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha", "protein_names_refseq": "CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:14272); (R-MMU-111465); (R-MMU-2514859); (R-MMU-9648002); (R-MMU-9953170)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;14622576;17652517;28135057;28528544;30084848;32052578;32848054;34315531;34428180;7590362", "class_list": "", "function": "Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion., [RefSeq, PubMed]; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation., [UniProtKB, PubMed, PubMed]; Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q921F7", "ec_number_list": "3.6.5.2;2.5.1.60;3.4.22.56;2.5.1.58;2.5.1.59;3.6.5.-", "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity;GO:0004663 Rab geranylgeranyltransferase activity;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex;GO:0005965 protein farnesyltransferase complex;GO:0005737 cytoplasm;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0018343 protein farnesylation;GO:0045787 positive regulation of cell cycle;GO:0035022 positive regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61585-1", "uniprot_id": "G0S2_MOUSE", "mass": 11118.0, "length": 103, "protein_name": "G0/G1 switch protein 2", "gene_name": "G0s2", "organism": "Mouse", "refseq_name": "G0/G1 switch protein 2", "refseq_ac": "NP_032085", "gene_names_uniprotkb": "G0s2", "gene_names_refseq": "G0s2", "protein_names_uniprotkb": "G0/G1 switch protein 2; G0S2-like protein", "protein_names_refseq": "G0/G1 switch protein 2; G0S2-like protein; putative lymphocyte G0/G1 switch protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14373)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16086669;20197052;21989031;37033250", "class_list": "", "function": "A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized., [RefSeq, PubMed]; Lipolysis is differently regulated between perigonadal and mesenteric adipocytes, and these depot-specific differences might be explained by altered regulation of G0S2 and/or perilipin., [RefSeq, PubMed]; Overexpression of G0S2 diminishes the rate of lipolysis in both adipocytes and adipose tissue explants, [RefSeq, PubMed]; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers., [UniProtKB]; The effect of G0S2 on insulin sensitivity: A proteomic analysis in a G0S2-overexpressed high-fat diet mouse model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0097191 extrinsic apoptotic signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61585-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q684R7-1", "uniprot_id": "FREM1_MOUSE", "mass": 244544.0, "length": 2191, "protein_name": "FRAS1-related extracellular matrix protein 1", "gene_name": "Frem1", "organism": "Mouse", "refseq_name": "FRAS1-related extracellular matrix protein 1 isoform 2 precursor", "refseq_ac": "NP_001185740", "gene_names_uniprotkb": "Frem1", "gene_names_refseq": "D430009N09; D630008K06; Frem1; crf11; eye; eyes2; heb; qbrick", "protein_names_uniprotkb": "FRAS1-related extracellular matrix protein 1; Protein QBRICK", "protein_names_refseq": "FRAS1-related extracellular matrix protein 1 isoform 2 precursor", "tax_id": 10090, "disease": "chromosome 9p deletion syndrome (Disease Ontology:DOID:0060732); Fraser syndrome (Disease Ontology:DOID:0090001); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:329872)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15345741;15878328;21750661;34428180;35820727;36495293", "class_list": "", "function": "Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development., [UniProtKB, PubMed]; Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis., [RefSeq, PubMed]; Frem1 appears to act as a dermal mediator of basement membrane adhesion and is required for epidermal adhesion during embryonic development, [RefSeq, PubMed]; QBRICK is an adhesive ligand of basement membrane distinctively recognized by cells in the embryonic skin and hair follicles through different types of integrins directed to the Arg-Gly-Asp motif., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q5H8C2;Q5M7B3;Q8C732", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0007160 cell-matrix adhesion;GO:0007154 cell communication;GO:0010669 epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q684R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NSQ9-1", "uniprot_id": "G6PC3_MOUSE", "mass": 38782.0, "length": 346, "protein_name": "Glucose-6-phosphatase 3", "gene_name": "G6pc3", "organism": "Mouse", "refseq_name": "glucose-6-phosphatase 3", "refseq_ac": "NP_787949", "gene_names_uniprotkb": "G6pc3; Ugrp", "gene_names_refseq": "0710001K01Rik; G6pc3; UGRP", "protein_names_uniprotkb": "Glucose-6-phosphatase 3; 3.1.3.9; G-6-Pase 3; G6Pase 3; Glc-6-Pase-beta; Ubiquitous glucose-6-phosphatase catalytic subunit-related protein; glucose-6-phosphatase-beta", "protein_names_refseq": "G-6-Pase 3; G6Pase 3; glc-6-Pase-beta; glucose-6-phosphatase 3; glucose-6-phosphatase catalytic subunit-related; glucose-6-phosphatase-beta; ubiquitous glucose-6-phosphatase catalytic subunit-related protein", "tax_id": 10090, "disease": "severe congenital neutropenia 4 (Disease Ontology:DOID:0112136)", "pathway": " (mmu:68401); (R-MMU-70263)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14765991;15087461;15661744;17023421;17318259;23686134;31219806", "class_list": "", "function": "Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-beta (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation., [RefSeq, PubMed]; The absence of G6Pase-beta led to neutropenia, [RefSeq, PubMed]; UGRP/G6Pase is the major glucose-6-phosphatase of physiological importance for glucose homeostasis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TND0;Q811R8", "ec_number_list": "3.1.3.94;3.1.3.25;3.1.3.9", "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0015760 glucose-6-phosphate transport;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6NSQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVD0-1", "uniprot_id": "FREM2_MOUSE", "mass": 350640.0, "length": 3160, "protein_name": "FRAS1-related extracellular matrix protein 2", "gene_name": "Frem2", "organism": "Mouse", "refseq_name": "FRAS1-related extracellular matrix protein 2 precursor", "refseq_ac": "NP_766450", "gene_names_uniprotkb": "Frem2; Nv1", "gene_names_refseq": "6030440P17Rik; 8430406N05Rik; Frem2; Gm409; b2b1562Clo; my; ne; nv1", "protein_names_uniprotkb": "FRAS1-related extracellular matrix protein 2; ECM3 homolog; NV domain-containing protein 1", "protein_names_refseq": "ECM3 homolog; FRAS1-related extracellular matrix protein 2 precursor; FRAS1-related extracellular matrix protein 2; NV domain containing protein NV1; NV domain-containing protein 1", "tax_id": 10090, "disease": "Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 2 (Disease Ontology:DOID:0111407); isolated cryptophthalmia (Disease Ontology:DOID:0111717)", "pathway": " (mmu:242022)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15838507;25428506;30802441;31219806;34418053;34428180;35820727", "class_list": "", "function": "Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:30802441)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q4W2Q5;Q5H8C0;Q811G9;Q8C4G5;Q8CD46", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0001822 kidney development;GO:0007160 cell-matrix adhesion;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q6NVD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PAJ3-1", "uniprot_id": "GARE2_MOUSE", "mass": 93510.0, "length": 880, "protein_name": "GRB2-associated and regulator of MAPK protein 2", "gene_name": "Garem2", "organism": "Mouse", "refseq_name": "GRB2-associated and regulator of MAPK protein 2", "refseq_ac": "NP_001161351", "gene_names_uniprotkb": "Garem2; Fam59b; Gareml; Gm444", "gene_names_refseq": "Fam59b; Garem2; Gareml; Gm444", "protein_names_uniprotkb": "GRB2-associated and regulator of MAPK protein 2; GRB2-associated and regulator of MAPK1-like", "protein_names_refseq": "GRB2 associated, regulator of MAPK1-like; GRB2-associated and regulator of MAPK protein 2; GRB2-associated and regulator of MAPK protein-like; GRB2-associated and regulator of MAPK1-like; family with sequence similarity 59, member B; protein FAM59B", "tax_id": 10090, "disease": "", "pathway": " (mmu:242915)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25605945;31718706", "class_list": "", "function": "GAREM2 may have a common role related to the transduction of Erk signaling in the higher brain functions. Publication Status: Online-Only, [RefSeq, PubMed]; Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14CH4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0050890 cognition;GO:0035176 social behavior;GO:0006950 response to stress;GO:1990138 neuron projection extension", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PAJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PB93-1", "uniprot_id": "GALT2_MOUSE", "mass": 64514.0, "length": 570, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 2", "gene_name": "Galnt2", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 2", "refseq_ac": "NP_644678", "gene_names_uniprotkb": "Galnt2", "gene_names_refseq": "Galnt2", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 2; 2.4.1.41; GalNAc-T2; Polypeptide GalNAc transferase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; pp-GaNTase 2", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2; galNAc-T2; polypeptide GalNAc transferase 2; polypeptide N-acetylgalactosaminyltransferase 2; pp-GaNTase 2; ppGaNTase-T2; protein-UDP acetylgalactosaminyltransferase 2", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIt (Disease Ontology:DOID:0051049)", "pathway": " (mmu:108148); (R-MMU-6811436); (R-MMU-913709)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12651884;18188647;25428506;27508872;31219806;32293671;34428180;36058918;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872)., [UniProtKB, PubMed]; The O-glycosylating enzyme GALNT2 acts as an oncogenic driver in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that the region responsible for the Mvwf1 regulatory switch lies within an approximately 30-kb genomic interval upstream of the B4galnt2 gene., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSI5;Q8BL27;Q922K5;Q99ME1", "ec_number_list": "2.4.1.-;2.4.1.41;3.6.5.-;3.6.5.2", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0051604 protein maturation;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 7434, "hit_score": 1.0, "record_id": "Q6PB93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80T14-1", "uniprot_id": "FRAS1_MOUSE", "mass": 442369.0, "length": 4010, "protein_name": "Extracellular matrix organizing protein FRAS1", "gene_name": "Fras1", "organism": "Mouse", "refseq_name": "extracellular matrix organizing protein FRAS1 precursor", "refseq_ac": "NP_780682", "gene_names_uniprotkb": "Fras1; Kiaa1500", "gene_names_refseq": "E130113P14Rik; Fras1; bl; mKIAA1500", "protein_names_uniprotkb": "Extracellular matrix organizing protein FRAS1", "protein_names_refseq": "Fraser syndrome 1 homolog; Fraser syndrome 1 protein; blebbed; extracellular matrix organizing protein FRAS1 precursor; extracellular matrix organizing protein FRAS1; extracellular matrix protein FRAS1", "tax_id": 10090, "disease": "Fraser syndrome (Disease Ontology:DOID:0090001); Fraser syndrome 1 (Disease Ontology:DOID:0111405); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:231470)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12766769;12766770;17322886;25428506;30899004;31219806;32333816;35820727", "class_list": "", "function": "Behavioural effects of extracellular matrix protein Fras1 depletion in the mouse., [RefSeq, PubMed]; Involved in extracellular matrix organization (PubMed:32333816). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (PubMed:12766769). Involved in brain organization and function (PubMed:32333816)., [UniProtKB, PubMed, PubMed]; Screened DNA from bl/bl mice and identified a premature termination of mouse Fras1. Thus, the bl mouse is a model for Fraser syndrome in humans., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 10, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "E9QPG9;Q80TC7;Q811H8;Q8BPZ4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007160 cell-matrix adhesion;GO:0030326 embryonic limb morphogenesis;GO:0007154 cell communication;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80T14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VA0-1", "uniprot_id": "GALT7_MOUSE", "mass": 75419.0, "length": 657, "protein_name": "N-acetylgalactosaminyltransferase 7", "gene_name": "Galnt7", "organism": "Mouse", "refseq_name": "N-acetylgalactosaminyltransferase 7 isoform 2", "refseq_ac": "NP_001161453", "gene_names_uniprotkb": "Galnt7", "gene_names_refseq": "Galnt7", "protein_names_uniprotkb": "N-acetylgalactosaminyltransferase 7; 2.4.1.41; GalNAc-T7; Polypeptide GalNAc transferase 7; Protein-UDP acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; pp-GaNTase 7", "protein_names_refseq": "N-acetylgalactosaminyltransferase 7 isoform 2; N-acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7; galNAc-T7; polypeptide GalNAc transferase 7; pp-GaNTase 7; ppGaNTase-T7; protein-UDP acetylgalactosaminyltransferase 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:108150); (R-MMU-913709)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10488133;26495903;26740625;30779550;34428180;37828378", "class_list": "glycogene;glycosyltransferase", "function": "Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY62;Q8BZ70;Q8BZW0;Q91VW6;Q99MD7", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.7, "record_id": "Q80VA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WP8-1", "uniprot_id": "GADL1_MOUSE", "mass": 62519.0, "length": 550, "protein_name": "Acidic amino acid decarboxylase GADL1", "gene_name": "Gadl1", "organism": "Mouse", "refseq_name": "acidic amino acid decarboxylase GADL1 isoform 2", "refseq_ac": "NP_082914", "gene_names_uniprotkb": "Gadl1", "gene_names_refseq": "1110027M19Rik; ADC; CSADC; Gadl1", "protein_names_uniprotkb": "Acidic amino acid decarboxylase GADL1; 4.1.1.11; 4.1.1.29; ADC; Aspartate 1-decarboxylase; CSADC; Cysteine sulfinic acid decarboxylase; Glutamate decarboxylase-like protein 1", "protein_names_refseq": "acidic amino acid decarboxylase GADL1 isoform 2; acidic amino acid decarboxylase GADL1; aspartate 1-decarboxylase; cysteine sulfinic acid decarboxylase; glutamate decarboxylase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73748); (R-MMU-1614558); (R-MMU-8963693)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;23038267;26327310;29372909", "class_list": "", "function": "Analysis of the role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis, [RefSeq, PubMed]; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate., [UniProtKB, PubMed]; Taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1), [RefSeq, PubMed]; The crystal structure of GADL1 is described, together with a solution model based on small-angle X-ray scattering data. While the overall fold and the conformation of the bound PLP are similar to those in other PLP-dependent decarboxylases, GADL1 adopts a more loose conformation in solution, which might have functional relevance in ligand binding and catalysis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTD2", "ec_number_list": "4.1.1.29;4.1.1.11", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004782 sulfinoalanine decarboxylase activity;GO:0004068 aspartate 1-decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80WP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKE5-1", "uniprot_id": "FSBP_MOUSE", "mass": 34403.0, "length": 299, "protein_name": "Fibrinogen silencer-binding protein", "gene_name": "Fsbp", "organism": "Mouse", "refseq_name": "fibrinogen silencer-binding protein", "refseq_ac": "NP_001243071", "gene_names_uniprotkb": "Fsbp", "gene_names_refseq": "Fsbp", "protein_names_uniprotkb": "Fibrinogen silencer-binding protein", "protein_names_refseq": "fibrinogen silencer-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJX8", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BKE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLX4-1", "uniprot_id": "FUCT1_MOUSE", "mass": 39967.0, "length": 363, "protein_name": "GDP-fucose transporter 1", "gene_name": "Slc35c1", "organism": "Mouse", "refseq_name": "GDP-fucose transporter 1 isoform 1", "refseq_ac": "NP_997597", "gene_names_uniprotkb": "Slc35c1; Fuct1", "gene_names_refseq": "E430007K15Rik; Slc35c1; fuct1", "protein_names_uniprotkb": "GDP-fucose transporter 1; Solute carrier family 35 member C1", "protein_names_refseq": "GDP-fucose transporter 1 isoform 1; GDP-fucose transporter 1; multispan transmembrane protein fuct1", "tax_id": 10090, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIc (Disease Ontology:DOID:0070255)", "pathway": " (mmu:228368); (R-MMU-6787639); (R-MMU-727802)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18541720;21750661;25605945;34203471", "class_list": "glycogene", "function": "Antiporter specific for GDP-l-fucose and depending on the concomitant reverse transport of GMP. Involved in GDP-fucose import from the cytoplasm into the Golgi lumen., [UniProtKB, UniProtKB]; Slc35c1(-/-) mice show strongly defective leukocyte trafficking but normal lymphocyte homing to the spleen, which may explain normal lymphocyte functions in LAD II., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMP5;Q8BV24", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005457 GDP-fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0042352 GDP-L-fucose salvage;GO:0009247 glycolipid biosynthetic process;GO:0045746 negative regulation of Notch signaling pathway;GO:0036085 GDP-fucose import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BLX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0T1-1", "uniprot_id": "FM1AB_MOUSE", "mass": 72210.0, "length": 654, "protein_name": "Protein fem-1 homolog A-like", "gene_name": "Fem1al", "organism": "Mouse", "refseq_name": "protein fem-1 homolog A-like", "refseq_ac": "NP_789799", "gene_names_uniprotkb": "Fem1al; Fem1ab", "gene_names_refseq": "4931440F15Rik; Fem1ab; Fem1al", "protein_names_uniprotkb": "Protein fem-1 homolog A-like; FEM1-alpha-B; FEM1a-B; Protein fem-1 homolog A-B", "protein_names_refseq": "FEM1-alpha-B; FEM1a-B; protein fem-1 homolog A-B; protein fem-1 homolog A-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:216622)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RT26;Q5RJ26", "ec_number_list": "", "go_molecular_function": "GO:0031867 EP4 subtype prostaglandin E2 receptor binding;GO:0060090 molecular adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000165 MAPK cascade;GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C0T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C102-1", "uniprot_id": "GALT5_MOUSE", "mass": 105780.0, "length": 930, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 5", "gene_name": "Galnt5", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 5", "refseq_ac": "NP_766443", "gene_names_uniprotkb": "Galnt5", "gene_names_refseq": "4832424J23; Galnt5", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 5; 2.4.1.41; GalNAc-T5; Polypeptide GalNAc transferase 5; Protein-UDP acetylgalactosaminyltransferase 5; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5; pp-GaNTase 5", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5; galNAc-T5; polypeptide GalNAc transferase 5; polypeptide N-acetylgalactosaminyltransferase 5; pp-GaNTase 5; ppGaNTase-T5; protein-UDP acetylgalactosaminyltransferase 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:241391); (R-MMU-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11159923", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 69, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2AS75", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "Q8C102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB93-1", "uniprot_id": "GAPT_MOUSE", "mass": 17601.0, "length": 157, "protein_name": "Protein GAPT", "gene_name": "Gapt", "organism": "Mouse", "refseq_name": "protein GAPT", "refseq_ac": "NP_808381", "gene_names_uniprotkb": "Gapt", "gene_names_refseq": "9830130M13Rik; Gapt", "protein_names_uniprotkb": "Protein GAPT; Growth factor receptor-bound protein 2-binding adapter protein, transmembrane", "protein_names_refseq": "growth factor receptor-bound protein 2-binding adapter protein, transmembrane; protein GAPT", "tax_id": 10090, "disease": "", "pathway": " (mmu:238875)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18559951", "class_list": "", "function": "Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0002322 B cell proliferation involved in immune response;GO:0001782 B cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CB93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K025-1", "uniprot_id": "FRAT2_MOUSE", "mass": 23914.0, "length": 231, "protein_name": "GSK-3-binding protein FRAT2", "gene_name": "Frat2", "organism": "Mouse", "refseq_name": "GSK-3-binding protein FRAT2", "refseq_ac": "NP_808271", "gene_names_uniprotkb": "Frat2", "gene_names_refseq": "Frat2", "protein_names_uniprotkb": "GSK-3-binding protein FRAT2; FRAT-2; Frequently rearranged in advanced T-cell lymphomas 2", "protein_names_refseq": "FRAT-2; GSK-3-binding protein FRAT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:212398); (R-MMU-196299); (R-MMU-4641262)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15073180;19802005;23074275;31961879", "class_list": "", "function": "Data show that MLL fusion oncogenes maintain leukemia-associated Rac GTPases activity by regulating Frat gene expression, specifically Frat2., [RefSeq, PubMed]; Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling., [RefSeq, PubMed]; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3., [UniProtKB]; TMEM98 reduces FRAT2 protein levels and, accordingly, inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0046825 regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K025-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2I0-1", "uniprot_id": "FOXE1_MOUSE", "mass": 37768.0, "length": 371, "protein_name": "Forkhead box protein E1", "gene_name": "Foxe1", "organism": "Mouse", "refseq_name": "forkhead box protein E1", "refseq_ac": "NP_899121", "gene_names_uniprotkb": "Foxe1; Titf2", "gene_names_refseq": "Foxe1; TTF-2; Titf2", "protein_names_uniprotkb": "Forkhead box protein E1; TTF-2; Thyroid transcription factor 2", "protein_names_refseq": "forkhead box protein E1; thyroid transcription factor 2", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Bamforth-Lazarus syndrome (Disease Ontology:DOID:0050655); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:110805)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12203737;21177256;22304410;9697704", "class_list": "", "function": "Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis., [RefSeq, PubMed]; Overexpression of TTF-2 during the palatogenesis may contribute to cleft palate., [RefSeq, PubMed]; Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor (PubMed:21177256). Also implicated in thyroid gland morphogenesis (PubMed:9697704). May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AM00", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R2I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XD4-1", "uniprot_id": "FTCD_MOUSE", "mass": 58939.0, "length": 541, "protein_name": "Formimidoyltransferase-cyclodeaminase", "gene_name": "Ftcd", "organism": "Mouse", "refseq_name": "formimidoyltransferase-cyclodeaminase", "refseq_ac": "NP_543121", "gene_names_uniprotkb": "Ftcd", "gene_names_refseq": "Ftcd", "protein_names_uniprotkb": "Formimidoyltransferase-cyclodeaminase; FTCD; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase-cyclodeaminase; Glutamate formiminotransferase; Glutamate formyltransferase", "protein_names_refseq": "formimidoyltransferase-cyclodeaminase; glutamate formiminotransferase", "tax_id": 10090, "disease": "glutamate formiminotransferase deficiency (Disease Ontology:DOID:0111679)", "pathway": " (mmu:14317); (R-MMU-70921)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20232291;31089130;34428180;37453647;38254641", "class_list": "", "function": "Autoreactive B cell response against formiminotransferase-cyclodeaminase correlated with disease activity, possibly linking B-cell autoreactivity and AIH pathogenesis, [RefSeq, PubMed]; Binds and promotes bundling of vimentin filaments originating from the Golgi., [UniProtKB]; Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.2.5;4.3.1.4", "go_molecular_function": "GO:0008017 microtubule binding;GO:0005542 folic acid binding;GO:0030409 glutamate formimidoyltransferase activity;GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0035999 tetrahydrofolate interconversion;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91XD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922E6-1", "uniprot_id": "FAKD2_MOUSE", "mass": 78948.0, "length": 689, "protein_name": "FAST kinase domain-containing protein 2, mitochondrial", "gene_name": "Fastkd2", "organism": "Mouse", "refseq_name": "FAST kinase domain-containing protein 2, mitochondrial", "refseq_ac": "NP_766010", "gene_names_uniprotkb": "Fastkd2", "gene_names_refseq": "2810421I24Rik; Fastkd2", "protein_names_uniprotkb": "FAST kinase domain-containing protein 2, mitochondrial", "protein_names_refseq": "FAST kinase domain-containing protein 2, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 44 (Disease Ontology:DOID:0070424)", "pathway": " (mmu:75619)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18771761;20869947;34428180", "class_list": "", "function": "Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. May play a role in mitochondrial apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLQ2;Q3U526;Q3UFY6;Q8BT79;Q8C3T6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006396 RNA processing;GO:0006915 apoptotic process;GO:0070131 positive regulation of mitochondrial translation;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q922E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923B0-1", "uniprot_id": "GGACT_MOUSE", "mass": 17080.0, "length": 149, "protein_name": "Gamma-glutamylaminecyclotransferase", "gene_name": "Ggact", "organism": "Mouse", "refseq_name": "gamma-glutamylaminecyclotransferase isoform 3", "refseq_ac": "NP_663441", "gene_names_uniprotkb": "Ggact; A2ld1", "gene_names_refseq": "A2ld1; Ggact", "protein_names_uniprotkb": "Gamma-glutamylaminecyclotransferase; 4.3.2.8; AIG2-like domain-containing protein 1; GGACT; Gamma-glutamylamine cyclotransferase", "protein_names_refseq": "AIG2-like domain 1; AIG2-like domain-containing protein 1; gamma-glutamylaminecyclotransferase isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:223267)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16224779;20944236;21750661;34428180", "class_list": "", "function": "Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66JP0", "ec_number_list": "4.3.2.8", "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042219 modified amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923B0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR13-1", "uniprot_id": "FMC1_MOUSE", "mass": 12695.0, "length": 113, "protein_name": "Protein FMC1 homolog", "gene_name": "Fmc1", "organism": "Mouse", "refseq_name": "protein FMC1 homolog", "refseq_ac": "NP_079639", "gene_names_uniprotkb": "Fmc1", "gene_names_refseq": "1110001J03Rik; Fmc1", "protein_names_uniprotkb": "Protein FMC1 homolog; Formation of mitochondrial complex V assembly factor 1", "protein_names_refseq": "UPF0562 protein C7orf55 homolog; formation of mitochondrial complexes 1 homolog; protein FMC1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0050995 negative regulation of lipid catabolic process;GO:0009636 response to toxic substance;GO:0007005 mitochondrion organization;GO:0008637 apoptotic mitochondrial changes;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CR13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX53-1", "uniprot_id": "GEMI6_MOUSE", "mass": 18750.0, "length": 166, "protein_name": "Gem-associated protein 6", "gene_name": "Gemin6", "organism": "Mouse", "refseq_name": "gem-associated protein 6", "refseq_ac": "NP_080329", "gene_names_uniprotkb": "Gemin6", "gene_names_refseq": "2610019B15Rik; 2810470M17Rik; Gemin6", "protein_names_uniprotkb": "Gem-associated protein 6; Gemin-6", "protein_names_refseq": "gem-associated protein 6; gemin-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67242); (R-MMU-191859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17023415;32848054", "class_list": "", "function": "Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIW7;Q9CQI0;Q9CXC5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032797 SMN complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CX53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1H7-1", "uniprot_id": "GET4_MOUSE", "mass": 36525.0, "length": 327, "protein_name": "Golgi to ER traffic protein 4 homolog", "gene_name": "Get4", "organism": "Mouse", "refseq_name": "Golgi to ER traffic protein 4 homolog isoform 2", "refseq_ac": "NP_001156788", "gene_names_uniprotkb": "Get4", "gene_names_refseq": "1110007L15Rik; Cee; Get4", "protein_names_uniprotkb": "Golgi to ER traffic protein 4 homolog", "protein_names_refseq": "Golgi to ER traffic protein 4 homolog isoform 2", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIy (Disease Ontology:DOID:0051052)", "pathway": " (mmu:67604)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78J86", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0031647 regulation of protein stability;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D1H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D799-1", "uniprot_id": "FMT_MOUSE", "mass": 43092.0, "length": 386, "protein_name": "Methionyl-tRNA formyltransferase, mitochondrial", "gene_name": "Mtfmt", "organism": "Mouse", "refseq_name": "methionyl-tRNA formyltransferase, mitochondrial", "refseq_ac": "NP_081410", "gene_names_uniprotkb": "Mtfmt; Fmt", "gene_names_refseq": "2310020P08Rik; Mtfmt", "protein_names_uniprotkb": "Methionyl-tRNA formyltransferase, mitochondrial; 2.1.2.9; MtFMT", "protein_names_refseq": "methionyl-tRNA formyltransferase, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 15 (Disease Ontology:DOID:0111491); nuclear type mitochondrial complex I deficiency 27 (Disease Ontology:DOID:0112090)", "pathway": " (mmu:69606)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30087118;35820727;36983072", "class_list": "", "function": "Here, we generated a Mtfmt-KO mouse fibroblast cell line and demonstrated that N-formylation of the first methionine via fMet-tRNA(Met) by MTFMT is not an absolute requirement for initiation of protein synthesis., [RefSeq, PubMed]; Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation., [UniProtKB, UniProtKB]; Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKZ0;Q8VE89", "ec_number_list": "2.1.2.9", "go_molecular_function": "GO:0004479 methionyl-tRNA formyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHE4-1", "uniprot_id": "G3ST1_MOUSE", "mass": 48968.0, "length": 423, "protein_name": "Galactosylceramide sulfotransferase", "gene_name": "Gal3st1", "organism": "Mouse", "refseq_name": "galactosylceramide sulfotransferase", "refseq_ac": "NP_001171162", "gene_names_uniprotkb": "Gal3st1; Cst; Gcst", "gene_names_refseq": "Cst; Gal3st1; Gcst", "protein_names_uniprotkb": "Galactosylceramide sulfotransferase; 2.8.2.11; 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; Cerebroside sulfotransferase; GalCer sulfotransferase", "protein_names_refseq": "3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase; 3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase; cerebroside sulfotransferase; galactosylceramide sulfotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:53897); (R-MMU-9840309)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10727929;11917099;34203471", "class_list": "glycogene", "function": "Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids (PubMed:11917099). Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (PubMed:11917099). Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro) (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8V6", "ec_number_list": "2.8.2.11", "go_molecular_function": "GO:0001733 galactosylceramide sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006665 sphingolipid metabolic process;GO:0042552 myelination;GO:0009247 glycolipid biosynthetic process;GO:0006682 galactosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JHE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIP6-1", "uniprot_id": "FZD2_MOUSE", "mass": 64059.0, "length": 570, "protein_name": "Frizzled-2", "gene_name": "Fzd2", "organism": "Mouse", "refseq_name": "frizzled-2 precursor", "refseq_ac": "NP_065256", "gene_names_uniprotkb": "Fzd2; Fzd10", "gene_names_refseq": "Fz10; Fzd10; Fzd2; Mfz10a; Mfz10", "protein_names_uniprotkb": "Frizzled-2; Frizzled-10; Fz-10; Fz-2; mFz10; mFz2", "protein_names_refseq": "frizzled homolog 2; frizzled-10; frizzled-2 precursor; frizzled-2; fz-10; fz-2; mFz2", "tax_id": 10090, "disease": "omodysplasia 2 (Disease Ontology:DOID:0080845); leiomyoma (Disease Ontology:DOID:127); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:57265); (R-MMU-4086398); (R-MMU-4608870); (R-MMU-4641262); (R-MMU-5140745)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;10903145;26740625", "class_list": "glycogene", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q810M0;Q9JIP5;Q9WUJ2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0030855 epithelial cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJE7-1", "uniprot_id": "FADS3_MOUSE", "mass": 51469.0, "length": 449, "protein_name": "Fatty acid desaturase 3", "gene_name": "Fads3", "organism": "Mouse", "refseq_name": "fatty acid desaturase 3", "refseq_ac": "NP_068690", "gene_names_uniprotkb": "Fads3; MNCb-0629", "gene_names_refseq": "Fads3", "protein_names_uniprotkb": "Fatty acid desaturase 3; 1.14.19.-; Delta(13) desaturase; Delta(13) fatty acid desaturase; FADS3", "protein_names_refseq": "delta(13) desaturase; delta(13) fatty acid desaturase; fatty acid desaturase 3", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (mmu:60527)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19752397;21750661;25428506;27216536;30084848;30400035;31219806;31862735;34428180", "class_list": "", "function": "Changes in expression patterns and fatty acid profiles suggest that Fads3AT9 may play a role in the regulation and/or biosynthesis of long chain polyunsaturated fatty acids from precursors., [RefSeq, PubMed]; FADS3 does exist under multiple protein isoforms depending on the mammalian tissues., [RefSeq, PubMed]; FADS3 is a Delta14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome., [RefSeq, PubMed]; Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base that comprises mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans (E) desaturation at carbon 4. FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH. Prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates. Capable of metabolizing also the SPH in its free form. SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides. Could be involved in the detoxification of 1-deoxy sphingolipids, by desaturating the cytotoxic 1-deoxysphinganine (1-deoxySA, m18:0), produced under pathological conditions, to 1-deoxysphingenine (1-deoxysphingosine, 1-deoxySO, m18:1). Although prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates, it also exhibits activity toward dihydrosphingosine-containing CERs (N-acylsphinganines) and produces 14Z-SPH-containing sphingolipids. Its desaturase mechanism involves an electron transfer facilitated by cytochrome b5 (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Strongly expressed in the decidual cells at implantation sites, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TND7;Q8C4Y5;Q8CDZ4", "ec_number_list": "1.14.19.-", "go_molecular_function": "GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006665 sphingolipid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0010467 gene expression;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2G1-1", "uniprot_id": "FM1AA_MOUSE", "mass": 72089.0, "length": 654, "protein_name": "Protein fem-1 homolog A-A", "gene_name": "Fem1aa", "organism": "Mouse", "refseq_name": "protein fem-1 homolog A-A", "refseq_ac": "NP_034322", "gene_names_uniprotkb": "Fem1aa; Eprap; Fem1a", "gene_names_refseq": "Eprap; Fem1aa; Fem1a", "protein_names_uniprotkb": "Protein fem-1 homolog A-A; FEM1-alpha-A; FEM1a-A; Prostaglandin E receptor 4-associated protein", "protein_names_refseq": "FEM1-alpha-A; FEM1a-A; feminization 1 homolog a; prostaglandin E receptor 4-associated protein; protein fem-1 homolog A-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:14154); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16254458;18270204;19406122;25428506;26439841;27315781;27799315;28336432;28624505;30084848;30779550;34428180;9828124", "class_list": "", "function": "Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis, [RefSeq, PubMed]; Immunoprecipitation analyses demonstrated that EPRAP associated with PP2A in both MEFs and alveolar macrophages from BLM-treated mice., [RefSeq, PubMed]; Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (PubMed:18270204, PubMed:26439841). Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (PubMed:27315781)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2C2;Q8C4V3;Q8C6D9;Q8CBW9;Q9DBC6", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z2G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5U5-1", "uniprot_id": "HDHD1_MOUSE", "mass": 26161.0, "length": 234, "protein_name": "Pseudouridine-5'-phosphatase", "gene_name": "Pudp", "organism": "Mouse", "refseq_name": "pseudouridine-5'-phosphatase", "refseq_ac": "NP_080384", "gene_names_uniprotkb": "Pudp; Hdhd1a; Hdhd1", "gene_names_refseq": "1700121L12Rik; GS1; Hdhd1a; Hdhd1; Pudp", "protein_names_uniprotkb": "Pseudouridine-5'-phosphatase; 3.1.3.96; 5'-PsiMPase; Haloacid dehalogenase-like hydrolase domain-containing protein 1A; Haloacid dehalogenase-like hydrolase domain-containing protein 1; Pseudouridine-5'-monophosphatase", "protein_names_refseq": "5'-PsiMPase; haloacid dehalogenase-like hydrolase domain containing 1A; haloacid dehalogenase-like hydrolase domain-containing protein 1A; haloacid dehalogenase-like hydrolase domain-containing protein 1; pseudouridine 5-phosphatase; pseudouridine-5'-monophosphatase; pseudouridine-5'-phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67365); (R-MMU-73614)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL33;Q9D9A0", "ec_number_list": "3.1.3.96", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:1990738 pseudouridine 5'-phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D5U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R098-1", "uniprot_id": "HGFA_MOUSE", "mass": 70568.0, "length": 653, "protein_name": "Hepatocyte growth factor activator serine protease", "gene_name": "Hgfac", "organism": "Mouse", "refseq_name": "hepatocyte growth factor activator serine protease preproprotein", "refseq_ac": "NP_062320", "gene_names_uniprotkb": "Hgfac", "gene_names_refseq": "HGFA; Hgfac", "protein_names_uniprotkb": "Hepatocyte growth factor activator serine protease; 3.4.21.-; HGF activator; HGFA serine protease; HGFA; Serine protease HGFAC", "protein_names_refseq": "HGF activator; HGFA serine protease; hepatocyte growth factor activator serine protease preproprotein; hepatocyte growth factor activator serine protease; serine protease HGFAC", "tax_id": 10090, "disease": "", "pathway": " (mmu:54426); (R-MMU-6806942)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10760594;11032833;15521012;16944957;17330941;21750661;34428180;36413406", "class_list": "", "function": "HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth., [RefSeq, PubMed]; HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway., [UniProtKB, PubMed]; This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKV4", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY80-1", "uniprot_id": "HACD1_MOUSE", "mass": 32327.0, "length": 281, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1", "gene_name": "Hacd1", "organism": "Mouse", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform 1", "refseq_ac": "NP_038963", "gene_names_uniprotkb": "Hacd1; Ptpla", "gene_names_refseq": "Hacd1; Ptpla", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; 3-hydroxyacyl-CoA dehydratase 1; 4.2.1.134; HACD1; Protein-tyrosine phosphatase-like member A", "protein_names_refseq": "protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a; protein-tyrosine phosphatase-like member A; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1", "tax_id": 10090, "disease": "congenital myopathy (Disease Ontology:DOID:0081337); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:30963); (R-MMU-75876)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10644438;21750661;22106411;26160855;28784662", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]; Data reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. GeneRIF: Loss of function in myoblasts, knockout mice and spontaneously affected Labrador retrievers leads to reduced myoblast fusion (hypotrophy), associated with modified lipid composition and physical properties of membranes., [RefSeq, PubMed]; Mutations in HACD1 can result in myopathies in humans; knockout mice lacking Hacd1 develop myopathic phenotypes. Data (including data from studies using knockout mice and cultured cells from knockout mice) suggest that HACD1 and HACD2 exhibit overlapping substrate specificities and thus appear to represent redundant activities in skeletal muscle., [RefSeq, PubMed]; Ptpla regulates myogenesis through Myog. Erratum:[Mol Cell Biol. 2017 Jul 28;37(16):e00236-17. doi: 10.1128/MCB.00236-17. PMID: 28754770], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6P7", "ec_number_list": "4.2.1.134;1.1.1.n12;4.2.1.107;4.2.1.119", "go_molecular_function": "GO:0019899 enzyme binding;GO:0046848 hydroxyapatite binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0030148 sphingolipid biosynthetic process;GO:0010811 positive regulation of cell-substrate adhesion;GO:0030497 fatty acid elongation;GO:0071529 cementum mineralization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QY80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06467-1", "uniprot_id": "HBAZ_MOUSE", "mass": 16235.0, "length": 142, "protein_name": "Hemoglobin subunit zeta", "gene_name": "Hba-x; Hbz", "organism": "Mouse", "refseq_name": "hemoglobin subunit zeta isoform 1", "refseq_ac": "NP_034535", "gene_names_uniprotkb": "Hba-x; Hbz; Hba-x; Hbz1", "gene_names_refseq": "Hba-x; Hbz", "protein_names_uniprotkb": "Hemoglobin subunit zeta; Alpha-like embryonic globin chain x; Hemoglobin zeta chain; Zeta-globin", "protein_names_refseq": "alpha-like embryonic globin chain x; hemaglobin zeta; hemoglobin subunit zeta isoform 1; hemoglobin subunit zeta; hemoglobin zeta chain; zeta-globin", "tax_id": 10090, "disease": "", "pathway": " (mmu:15126)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;2444404;25428506;4000117;6084630", "class_list": "", "function": "The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61654", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3SXD3-1", "uniprot_id": "HDDC2_MOUSE", "mass": 22753.0, "length": 199, "protein_name": "5'-deoxynucleotidase HDDC2", "gene_name": "Hddc2", "organism": "Mouse", "refseq_name": "5'-deoxynucleotidase HDDC2 isoform 1", "refseq_ac": "NP_081444", "gene_names_uniprotkb": "Hddc2", "gene_names_refseq": "2310057G13Rik; Hddc2", "protein_names_uniprotkb": "5'-deoxynucleotidase HDDC2; 3.1.3.89; HD domain-containing protein 2", "protein_names_refseq": "5'-deoxynucleotidase HDDC2 isoform 1; 5'-deoxynucleotidase HDDC2; HD domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69692)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CV20", "ec_number_list": "3.1.3.5;3.1.3.89;3.1.3.99;3.1.3.91;3.1.3.35", "go_molecular_function": "GO:0046872 metal ion binding;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3SXD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5Q4-1", "uniprot_id": "GRSF1_MOUSE", "mass": 53076.0, "length": 479, "protein_name": "G-rich sequence factor 1", "gene_name": "Grsf1", "organism": "Mouse", "refseq_name": "G-rich sequence factor 1 isoform 2", "refseq_ac": "NP_001091946", "gene_names_uniprotkb": "Grsf1", "gene_names_refseq": "D5Wsu31e; Grsf1", "protein_names_uniprotkb": "G-rich sequence factor 1; GRSF-1", "protein_names_refseq": "G-rich sequence factor 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231413)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15345747;15857914;21750661;25428506;34078750;34428180;34887587;37861894", "class_list": "", "function": "Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis., [RefSeq, PubMed]; GRSF1 deficiency in skeletal muscle reduces endurance in aged mice., [RefSeq, PubMed]; Grsf1 is important for axial elongation, mid/hindbrain development and axial mesoderm specification., [RefSeq, PubMed]; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BR05;Q8BRG7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0009952 anterior/posterior pattern specification;GO:0016331 morphogenesis of embryonic epithelium;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C5Q4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01896-1", "uniprot_id": "HA1Z_MOUSE", "mass": 20454.0, "length": 185, "protein_name": "H-2 class I histocompatibility antigen, alpha chain", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, alpha chain; Clone PH-2D-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "25605945;26495903;6786753", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q31209", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P01896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01904-1", "uniprot_id": "HA21_MOUSE", "mass": 29117.0, "length": 255, "protein_name": "H-2 class II histocompatibility antigen, E-D alpha chain", "gene_name": "H2-Ea", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Ea; H2-Ea-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, E-D alpha chain; H2-IE-alpha", "protein_names_refseq": "", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); prediabetes syndrome (Disease Ontology:DOID:11716); allergic disease (Disease Ontology:DOID:1205); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); bipolar disorder (Disease Ontology:DOID:3312); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:100504404); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-2132295); (R-MMU-389948)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10903728;15094798;16075062;1656278;21750661;21913724;26495903;26740625;2701937;2769184;3755150;37828378;6296871;6300851;6308570;6403249;6415003;6815800;6937437;7495754", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q31157", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0045622 regulation of T-helper cell differentiation;GO:0050890 cognition;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P01904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02301-1", "uniprot_id": "H3C_MOUSE", "mass": 15315.0, "length": 136, "protein_name": "Histone H3.3C", "gene_name": "H3-5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H3-5; Gm14384; H3f3c", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H3.3C; Embryonic", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "33300544;6457299", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06339-1", "uniprot_id": "HA15_MOUSE", "mass": 40875.0, "length": 357, "protein_name": "H-2 class I histocompatibility antigen, D-37 alpha chain", "gene_name": "H2-T23", "organism": "Mouse", "refseq_name": "H-2 class I histocompatibility antigen, D-37 alpha chain precursor", "refseq_ac": "NP_034528", "gene_names_uniprotkb": "H2-T23", "gene_names_refseq": "37b; 37c; H-2T23; H2-K1; H2-Qa1; H2-T23; Qa-1(b); Qa-1; Qa1; Qed-1; T18c(37); T18c; T23b; T23d", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, D-37 alpha chain", "protein_names_refseq": "H-2 class I histocompatibility antigen, D-37 alpha chain precursor; H-2 class I histocompatibility antigen, D-37 alpha chain; MHC class I antigen Qa1; MHC class II antigen K; MHC classIb Qa1", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:15040)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19144319;28011936;30084848;3036997;34428180;38022509;3838699", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]; The promiscuous development of an unconventional Qa1b-restricted T cell population. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 51, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P06339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06344-1", "uniprot_id": "HB2U_MOUSE", "mass": 30041.0, "length": 263, "protein_name": "H-2 class II histocompatibility antigen, A-U beta chain", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, A-U beta chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "3086866;3500915;35984892", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P06344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19639-1", "uniprot_id": "GSTM3_MOUSE", "mass": 25702.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 3", "gene_name": "Gstm3", "organism": "Mouse", "refseq_name": "glutathione S-transferase Mu 3", "refseq_ac": "NP_034489", "gene_names_uniprotkb": "Gstm3", "gene_names_refseq": "Fsc2; Gstm3; mGSTM5", "protein_names_uniprotkb": "Glutathione S-transferase Mu 3; 2.5.1.18; GST class-mu 3; Glutathione S-transferase GT9.3", "protein_names_refseq": "GST class-mu 3; glutathione S-transferase GT9.3; glutathione S-transferase Mu 3", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); colorectal carcinoma (Disease Ontology:DOID:0080199); erythema nodosum (Disease Ontology:DOID:0080750); graft-versus-host disease (Disease Ontology:DOID:0081267); osteonecrosis (Disease Ontology:DOID:10159); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); lymphoid leukemia (Disease Ontology:DOID:1037); esophageal atresia (Disease Ontology:DOID:10485); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); aplastic anemia (Disease Ontology:DOID:12449); autistic disorder (Disease Ontology:DOID:12849); uterine fibroid (Disease Ontology:DOID:13223); lung cancer (Disease Ontology:DOID:1324); angle-closure glaucoma (Disease Ontology:DOID:13550); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); acute chest syndrome (Disease Ontology:DOID:1584); keratosis (Disease Ontology:DOID:161); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); malignant mesothelioma (Disease Ontology:DOID:1790); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); movement disease (Disease Ontology:DOID:480); small intestine adenocarcinoma (Disease Ontology:DOID:4906); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14864); (R-MMU-156590)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "24859727;25428506;30084848;3417659;34428180;3864155;6822548", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB]; Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 112, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0009617 response to bacterium;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P19639-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2KHK6-1", "uniprot_id": "GSDC2_MOUSE", "mass": 53952.0, "length": 480, "protein_name": "Gasdermin-C2", "gene_name": "Gsdmc2", "organism": "Mouse", "refseq_name": "gasdermin-C2", "refseq_ac": "NP_001161746", "gene_names_uniprotkb": "Gsdmc2", "gene_names_refseq": "9130023H10; Gsdmc2", "protein_names_uniprotkb": "Gasdermin-C2", "protein_names_refseq": "gasdermin-C2", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:331063)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17350798;34290141", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis in response to type-2 immunity (PubMed:34290141). Produced by the cleavage of gasdermin-C2 in response to type-2 immunity following worm infection (PubMed:34290141). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (By similarity). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis and lytic cell death in enterocytes (PubMed:34290141)., [UniProtKB, UniProtKB, PubMed]; This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C2, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHK8;Q8CC94", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0060576 intestinal epithelial cell development;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KHK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32M21-1", "uniprot_id": "GSDA2_MOUSE", "mass": 49844.0, "length": 443, "protein_name": "Gasdermin-A2", "gene_name": "Gsdma2", "organism": "Mouse", "refseq_name": "gasdermin-A2 isoform 1", "refseq_ac": "NP_084003", "gene_names_uniprotkb": "Gsdma2; Gsdm2", "gene_names_refseq": "2200001G21Rik; 2210006M16Rik; 2210009F20Rik; 2210411P14Rik; Gsdm2; GsdmA-2; Gsdma2; Gsdml2", "protein_names_uniprotkb": "Gasdermin-A2; Gasdermin-2", "protein_names_refseq": "gasdermin-2; gasdermin-A2 isoform 1; gasderminA-2", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:76758)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17350798;35110732;35545676;36064721", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage of Gasdermin-A2, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate., [UniProtKB, UniProtKB]; This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon bacterial infection, specifically cleaved by some bacterial effector protein, releasing the N-terminal moiety (Gasdermin-A2, N-terminal) that binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF01;Q9D810", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q32M21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QNS5-1", "uniprot_id": "HAVR1_MOUSE", "mass": 33361.0, "length": 305, "protein_name": "Hepatitis A virus cellular receptor 1 homolog", "gene_name": "Havcr1", "organism": "Mouse", "refseq_name": "hepatitis A virus cellular receptor 1 homolog isoform b precursor", "refseq_ac": "NP_001160103", "gene_names_uniprotkb": "Havcr1; Kim1; Tim1; Timd1", "gene_names_refseq": "Havcr1; KIM-1; TIM-1; Tim1; Timd1", "protein_names_uniprotkb": "Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; KIM-1; Kidney injury molecule 1; T cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin mucin receptor 1; TIM-1; TIMD-1", "protein_names_refseq": "HAVcr-1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin mucin receptor 1; TIMD-1; hepatitis A virus cellular receptor 1 homolog isoform b precursor; hepatitis A virus cellular receptor 1 homolog; kidney injury molecule 1; t cell immunoglobulin and mucin domain-containing protein 1; t cell membrane protein 1", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); acute kidney tubular necrosis (Disease Ontology:DOID:12556); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:171283)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11725301;14534576;15793575;15793576;17363299;21750661;21821911;24703780;25582854;25645598;26726878;32668241;37460623;39145457", "class_list": "", "function": "A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (PubMed:21821911, PubMed:25645598, PubMed:32668241). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (By similarity). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (By similarity). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (By similarity). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Acts as a regulator of T-cell proliferation (PubMed:15793576). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (PubMed:25582854, PubMed:25645598)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Protective effects of hepatitis A virus on atopic disease depends on a common TIM-1 allele, [RefSeq, PubMed]; TIM-1 is a molecule that costimulates T cell activation, [RefSeq, PubMed]; TIM-1-TIM-4 interaction is involved in regulating T cell proliferation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPU2;Q8VIM1;Q8VIM2", "ec_number_list": "", "go_molecular_function": "GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005903 brush border;GO:0009986 cell surface;GO:0031514 motile cilium", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0032496 response to lipopolysaccharide;GO:0009611 response to wounding;GO:0033005 positive regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5QNS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64522-1", "uniprot_id": "H2A2B_MOUSE", "mass": 14013.0, "length": 130, "protein_name": "Histone H2A type 2-B", "gene_name": "H2ac21", "organism": "Mouse", "refseq_name": "histone H2A type 2-B", "refseq_ac": "NP_835585", "gene_names_uniprotkb": "H2ac21; Hist2h2ab", "gene_names_refseq": "EG621893; H2a-613a; H2ac21; Hist2h2ab", "protein_names_uniprotkb": "Histone H2A type 2-B; H2A-clustered histone 21; H2a-613A", "protein_names_refseq": "histone 2, H2ab; histone H2A type 2-B; histone cluster 2, H2ab", "tax_id": 10090, "disease": "", "pathway": " (mmu:621893); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "15509584;15525528;16699504;24352239;24681537;25428506;27105115;30084848;30154464;34428180;36288343;37507081;8858345", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q64522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6I6G8-1", "uniprot_id": "HECW2_MOUSE", "mass": 176235.0, "length": 1578, "protein_name": "E3 ubiquitin-protein ligase HECW2", "gene_name": "Hecw2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase HECW2 isoform 1", "refseq_ac": "NP_001001883", "gene_names_uniprotkb": "Hecw2; Kiaa1301; Nedl2", "gene_names_refseq": "A730039N16Rik; D030049F17Rik; Gm971; Hecw2; Nedl2; mKIAA1301", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECW2; 2.3.2.26; HECT, C2 and WW domain-containing protein 2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2", "protein_names_refseq": "E3 ubiquitin-protein ligase HECW2 isoform 1; E3 ubiquitin-protein ligase HECW2; HECT, C2 and WW domain-containing protein 2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2; NEDD4-related E3 ubiquitin ligase NEDL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:329152); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15284439;21183079;25428506;25555806;27119228;29260931;30084848;31219806", "class_list": "", "function": "Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition., [UniProtKB, UniProtKB]; Grk2 phosphorylates the C terminus of the Na-channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2, [RefSeq, PubMed]; NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway., [RefSeq, PubMed]; That circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5 Erratum:[Autophagy. 2022 Jan;18(1):234. doi: 10.1080/15548627.2020.1751979. PMID: 32286128], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNL8;Q6ZPU4;Q8C956", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0072686 mitotic spindle", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6I6G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1G0-1", "uniprot_id": "HEAT6_MOUSE", "mass": 128922.0, "length": 1184, "protein_name": "HEAT repeat-containing protein 6", "gene_name": "Heatr6", "organism": "Mouse", "refseq_name": "HEAT repeat-containing protein 6", "refseq_ac": "NP_663407", "gene_names_uniprotkb": "Heatr6", "gene_names_refseq": "2700008B19Rik; Heatr6", "protein_names_uniprotkb": "HEAT repeat-containing protein 6", "protein_names_refseq": "HEAT repeat-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:217026)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;30084848;34418053;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUN8;Q99KZ5;Q9CSQ4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P1G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UW0-1", "uniprot_id": "H6ST2_MOUSE", "mass": 69198.0, "length": 612, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 2", "gene_name": "Hs6st2", "organism": "Mouse", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 2 isoform 1", "refseq_ac": "NP_001070670", "gene_names_uniprotkb": "Hs6st2", "gene_names_refseq": "6OST2; Hs6st2", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 2; 2.8.2.-; HS6ST-2; mHS6ST-2", "protein_names_refseq": "heparan-sulfate 6-O-sulfotransferase 2 isoform 1", "tax_id": 10090, "disease": "Paganini-Miozzo syndrome (Disease Ontology:DOID:0111843)", "pathway": " (mmu:50786); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10644753;15499561;34428180;37828378;38015989;38058080", "class_list": "glycogene", "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB]; 6OST2 is more mesenchymal than its isoenzymes during development, [RefSeq, PubMed]; Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration and Invasion in Vivo and in Vitro., [RefSeq, PubMed]; Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2AEM4;Q3TAR0;Q6P4N9;Q8C785;Q9QYK6", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80UW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKT8-1", "uniprot_id": "HAUS7_MOUSE", "mass": 40656.0, "length": 364, "protein_name": "HAUS augmin-like complex subunit 7", "gene_name": "Haus7", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 7 isoform 1", "refseq_ac": "NP_082909", "gene_names_uniprotkb": "Haus7; Uchl5ip; Uip1", "gene_names_refseq": "1110020L19Rik; Haus7; Uchl5ip; Uip1", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein", "protein_names_refseq": "26S proteasome-associated UCH37-interacting protein 1; HAUS augmin-like complex subunit 7 isoform 1; UCHL5-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73738); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "11163772;23182369;31599954", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]; Data suggest Uchl5ip has role in spindle formation in oocyte meiotic maturation; Uchl5ip protein level is consistent during metaphase I/II; Uchl5ip localizes to meiotic spindle; loss of Uchl5ip disrupts localization of gamma-tubulin to spindle poles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIF2;Q924Z7", "ec_number_list": "", "go_molecular_function": "GO:0031996 thioesterase binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0036064 ciliary basal body;GO:0097228 sperm principal piece", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly;GO:0031023 microtubule organizing center organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BKT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW56-1", "uniprot_id": "QTMAN_MOUSE", "mass": 51017.0, "length": 445, "protein_name": "tRNA-queuosine alpha-mannosyltransferase", "gene_name": "Gtdc1; Qtman", "organism": "Mouse", "refseq_name": "tRNA-queuosine alpha-mannosyltransferase", "refseq_ac": "NP_766250", "gene_names_uniprotkb": "Gtdc1; Qtman; Gtdc1", "gene_names_refseq": "E330008O22Rik; Gtdc1; Qtman", "protein_names_uniprotkb": "tRNA-queuosine alpha-mannosyltransferase; 2.4.1.110; Glycosyltransferase-like domain-containing protein 1; QTMAN", "protein_names_refseq": "glycosyltransferase-like domain containing 1; glycosyltransferase-like domain-containing protein 1; tRNA-queuosine alpha-mannosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:227835)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20173027;21750661;34203471;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQR9;A2AQS2;A2AVU2;Q3TQ41;Q80US3;Q8C1B8", "ec_number_list": "2.4.1.110", "go_molecular_function": "GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BW56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCK0-1", "uniprot_id": "H2AW_MOUSE", "mass": 40092.0, "length": 372, "protein_name": "Core histone macro-H2A.2", "gene_name": "Macroh2a2", "organism": "Mouse", "refseq_name": "core histone macro-H2A.2", "refseq_ac": "NP_996883", "gene_names_uniprotkb": "Macroh2a2; H2afy2; H2afy3", "gene_names_refseq": "H2afy2; Macroh2a2", "protein_names_uniprotkb": "Core histone macro-H2A.2; Histone macroH2A2; mH2A2", "protein_names_refseq": "H2A histone family, member Y2; core histone macro-H2A.2; histone macroH2A2; mH2A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:404634)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11262398;11331621;23463008;30084848;37605008", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Nov 2015]., [RefSeq]; MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping., [RefSeq, PubMed]; MacroH2A1 and macroH2A2, together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts. Erratum:[Nat Commun. 2013;4:2090], [RefSeq, PubMed]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JP36;Q3TNT4;Q925I6", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0031490 chromatin DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000786 nucleosome;GO:0001740 Barr body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0006334 nucleosome assembly;GO:0045814 negative regulation of gene expression, epigenetic;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CCK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGP2-1", "uniprot_id": "H2B1P_MOUSE", "mass": 13992.0, "length": 126, "protein_name": "Histone H2B type 1-P", "gene_name": "Hist1h2bp", "organism": "Mouse", "refseq_name": "histone H2B type 1-P isoform 2", "refseq_ac": "NP_001277395", "gene_names_uniprotkb": "Hist1h2bp", "gene_names_refseq": "H2bc22; Hist1h2bp", "protein_names_uniprotkb": "Histone H2B type 1-P", "protein_names_refseq": "histone 1, H2bp; histone H2B type 1-P isoform 2; histone H2B type 1-P; histone cluster 1, H2bp", "tax_id": 10090, "disease": "", "pathway": " (mmu:319188); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 13, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;2707490;27105115;30154464;31645732;32822587;33300544", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64477;Q6P8V8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CGP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WM2-1", "uniprot_id": "HDHD5_MOUSE", "mass": 46306.0, "length": 419, "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing 5", "gene_name": "Hdhd5", "organism": "Mouse", "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing 5 precursor", "refseq_ac": "NP_659064", "gene_names_uniprotkb": "Hdhd5; Cecr5", "gene_names_refseq": "A930002G03Rik; Cecr5; Hdhd5", "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing 5; Cat eye syndrome critical region protein 5 homolog", "protein_names_refseq": "cat eye syndrome chromosome region, candidate 5 homolog; cat eye syndrome critical region protein 5 homolog; haloacid dehalogenase-like hydrolase domain-containing 5 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:214932)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046474 glycerophospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91WM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ70-1", "uniprot_id": "H2AB1_MOUSE", "mass": 12843.0, "length": 111, "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2ab1", "organism": "Mouse", "refseq_name": "histone H2A-Bbd type 1", "refseq_ac": "NP_080903", "gene_names_uniprotkb": "H2ab1; H2afb1; H2al2a", "gene_names_refseq": "1700113O17Rik; H2A.Bbd; H2A.L.2; H2ab1; H2afb1; H2al2a; H2al2; TSEG-1; Tseg1", "protein_names_uniprotkb": "Histone H2A-Bbd type 1; H2A Barr body-deficient; H2A.Bbd; H2A.L.2; H2AL2; Histone H2A-like 2; Histone H2Alike 2; TSEG-1; Testis-specific expressed gene 1 protein", "protein_names_refseq": "H2A Barr body-deficient; H2A histone family, member B1; histone H2A-Bbd type 1; histone H2A-like 2; histone H2Alike 2; histone variant H2al2; testis-specific expressed gene 1 protein; testis-specific expressed protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68231)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17261847;18332006;18703863;19506029;20008104;20188161;25135723;28366643", "class_list": "", "function": "Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643)., [UniProtKB, PubMed, PubMed]; H2AL1 and H2AL2, specifically mark the pericentric regions in condensing spermatids and participate in the formation of new nucleoprotein structures, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]., [RefSeq]; Results indicated that TSEG-1 was cloned from X chromosome, with full-length sequence of 510 bp. The ORF is 336 bp that en-codes a deduced amino acid sequence of 111 residues. It was distinctively expressed in testis, but not in other tissues . : [TSEG-1], [RefSeq, PubMed]; The incorporation of H2A.L.2 initiates and orchestrates a series of successive transitional states that ultimately shift to the fully compacted genome of the mature spermatozoa., [RefSeq, PubMed]; The unusual properties of the H2AL2 nucleosomes suggest a specific role of H2AL2 during mouse spermiogenesis., [RefSeq, PubMed]; These results indicated over-expression of TSEG-1 suppresses the proliferation and induces the apoptosis of GC-1spg cells, which establishes a basis for further study on the function of TSEG-, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9Q5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0042393 histone binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0005721 pericentric heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation;GO:0051276 chromosome organization;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQ70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQS9-1", "uniprot_id": "HAUS2_MOUSE", "mass": 26839.0, "length": 234, "protein_name": "HAUS augmin-like complex subunit 2", "gene_name": "Haus2", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 2 isoform b", "refseq_ac": "NP_001277736", "gene_names_uniprotkb": "Haus2; Cep27", "gene_names_refseq": "1700101G24Rik; 2410007P03Rik; Cep27; Haus2", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 2; Centrosomal protein of 27 kDa; Cep27", "protein_names_refseq": "HAUS augmin-like complex subunit 2 isoform b; centrosomal protein 27; centrosomal protein of 27 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:66296); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKH8;A2AKI1;Q3V1R1;Q9CRI2;Q9D9D0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0007098 centrosome cycle;GO:0051225 spindle assembly;GO:0031023 microtubule organizing center organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2G9-1", "uniprot_id": "HIPL2_MOUSE", "mass": 79998.0, "length": 717, "protein_name": "HHIP-like protein 2", "gene_name": "Hhipl2", "organism": "Mouse", "refseq_name": "HHIP-like protein 2 isoform 2", "refseq_ac": "NP_001294981", "gene_names_uniprotkb": "Hhipl2; Hhip3; Kiaa1822l", "gene_names_refseq": "4930507C10Rik; Hhip3; Hhipl2", "protein_names_uniprotkb": "HHIP-like protein 2", "protein_names_refseq": "HHIP-like protein 2 isoform 2; HHIP-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D2G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3N8-1", "uniprot_id": "GRTP1_MOUSE", "mass": 40628.0, "length": 359, "protein_name": "Growth hormone-regulated TBC protein 1", "gene_name": "Grtp1", "organism": "Mouse", "refseq_name": "growth hormone-regulated TBC protein 1 isoform 1", "refseq_ac": "NP_080044", "gene_names_uniprotkb": "Grtp1; Tbc1d6", "gene_names_refseq": "5430401C05Rik; Grtp1; Tbc1d6", "protein_names_uniprotkb": "Growth hormone-regulated TBC protein 1; TBC1 domain family member 6", "protein_names_refseq": "TBC1 domain family member 6; growth hormone-regulated TBC protein 1 isoform 1; growth hormone-regulated TBC protein 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (mmu:66790)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11564724;21750661;34428180", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUR0;Q8VI03;Q9D3Q5;Q9D8L8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D3N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D786-1", "uniprot_id": "HAUS5_MOUSE", "mass": 69572.0, "length": 619, "protein_name": "HAUS augmin-like complex subunit 5", "gene_name": "Haus5", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 5", "refseq_ac": "NP_082275", "gene_names_uniprotkb": "Haus5; Kiaa0841", "gene_names_refseq": "2310022K01Rik; Haus5", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 5", "protein_names_refseq": "HAUS augmin-like complex subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:71909); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "25428506;30084848;30779550;34428180;35820727", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EB3;Q0VF86;Q5HZI7;Q6ZQ35;Q8CIK2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU63-1", "uniprot_id": "HEBP2_MOUSE", "mass": 23063.0, "length": 205, "protein_name": "Heme-binding protein 2", "gene_name": "Hebp2", "organism": "Mouse", "refseq_name": "heme-binding protein 2", "refseq_ac": "NP_062360", "gene_names_uniprotkb": "Hebp2; Soul", "gene_names_refseq": "Hebp2; SOUL", "protein_names_uniprotkb": "Heme-binding protein 2; Protein SOUL", "protein_names_refseq": "heme-binding protein 2; putative heme-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56016); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10640688;15518569;21750661;30501057", "class_list": "", "function": "Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions (By similarity). May have low affinity for heme (PubMed:15518569)., [UniProtKB, UniProtKB]; Results provide a better understanding of the target recognition mechanism and conformational change of SOUL in the interaction with ALG-2. Publication Status: Online-Only, [RefSeq, PubMed]; The heme-binding properties and coordination structure of SOUL protein are distinct from those of mouse liver p22HBP, despite high sequence homology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WU63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0R0-1", "uniprot_id": "HASP_MOUSE", "mass": 84181.0, "length": 754, "protein_name": "Serine/threonine-protein kinase haspin", "gene_name": "Haspin", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase haspin", "refseq_ac": "NP_034483", "gene_names_uniprotkb": "Haspin; Gsg2", "gene_names_refseq": "Gsg2; Haspin", "protein_names_uniprotkb": "Serine/threonine-protein kinase haspin; 2.7.11.1; Germ cell-specific gene 2 protein; Haploid germ cell-specific nuclear protein kinase", "protein_names_refseq": "germ cell associated 2, haspin; germ cell-specific gene 2 protein; haploid germ cell-specific nuclear protein kinase; serine/threonine-protein kinase haspin", "tax_id": 10090, "disease": "", "pathway": " (mmu:14841)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10358056;11311555;11311556;15681610;21183079;21750661;27562071;34428180;34615946;35694956;39073155;7957958", "class_list": "", "function": "Distinct roles of haspin in stem cell division and male gametogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in mouse embryonic stem cells., [RefSeq, PubMed]; Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis., [RefSeq, PubMed]; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MU9;Q9JJJ4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0003677 DNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0045143 homologous chromosome segregation;GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z0R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKA5-1", "uniprot_id": "GPA33_MOUSE", "mass": 35692.0, "length": 319, "protein_name": "Cell surface A33 antigen", "gene_name": "Gpa33", "organism": "Mouse", "refseq_name": "cell surface A33 antigen isoform 1 precursor", "refseq_ac": "NP_067623", "gene_names_uniprotkb": "Gpa33", "gene_names_refseq": "2010310L10Rik; 2210401D16Rik; Gpa33; mA33", "protein_names_uniprotkb": "Cell surface A33 antigen; Glycoprotein A33; mA33", "protein_names_refseq": "cell surface A33 antigen isoform 1 precursor; cell surface A33 antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:59290)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10960348;12114523;21750661;26035389", "class_list": "", "function": "Cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1, [RefSeq, PubMed]; Gpa33(-/-) mice provide a valuable model to study the mechanisms linking intestinal permeability and multiple inflammatory pathologies., [RefSeq, PubMed]; May play a role in cell-cell recognition and signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q922D5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JKA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R257-1", "uniprot_id": "HEBP1_MOUSE", "mass": 21067.0, "length": 190, "protein_name": "Heme-binding protein 1", "gene_name": "Hebp1", "organism": "Mouse", "refseq_name": "heme-binding protein 1", "refseq_ac": "NP_038574", "gene_names_uniprotkb": "Hebp1; Hbp", "gene_names_refseq": "Hebp1; Hebp; p22HBP", "protein_names_uniprotkb": "Heme-binding protein 1; p22HBP", "protein_names_refseq": "heme-binding protein 1; p22 HBP", "tax_id": 10090, "disease": "", "pathway": " (mmu:15199); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10640688;12413491;15518569;16905148;16905545;20800521;21750661;30084848;33258327;34105348;34428180;35796141;37324943;37828378;9813049", "class_list": "", "function": "Characterization as a tetrapyrrole-binding protein, [RefSeq, PubMed]; Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. Publication Status: Online-Only, [RefSeq, PubMed]; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice., [RefSeq, PubMed]; Results present a systematic molecular modeling study of the binding properties of murine and human p22HBP protein (heme-binding protein) with four tetrapyrrole ring systems belonging to the heme biosynthetic pathway., [RefSeq, PubMed]; The heme-binding properties and coordination structure of mouse liver p22HBP are distinct from those of SOUL protein, despite high sequence homology., [RefSeq, PubMed]; Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88814", "ec_number_list": "", "go_molecular_function": "GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042168 heme metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9R257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28798-1", "uniprot_id": "GRN_MOUSE", "mass": 63458.0, "length": 589, "protein_name": "Progranulin", "gene_name": "Grn", "organism": "Mouse", "refseq_name": "progranulin precursor", "refseq_ac": "NP_032201", "gene_names_uniprotkb": "Grn", "gene_names_refseq": "GP88; Grn; PCDGF; PEPI; Pgrn; epithelin", "protein_names_uniprotkb": "Progranulin; Acrogranin; Epithelin/granulin precursor; GP88; Glycoprotein 88; Glycoprotein of 88 Kda; PC cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin", "protein_names_refseq": "PC cell-derived growth factor; acrogranin; acrogranulin; epithelin/granulin; glycoprotein 88; glycoprotein of 88 Kda; granulins; proepithelin; progranulin precursor; progranulin", "tax_id": 10090, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); frontotemporal dementia 2 (Disease Ontology:DOID:0060672); neuronal ceroid lipofuscinosis 11 (Disease Ontology:DOID:0110732); Alzheimer's disease (Disease Ontology:DOID:10652); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (mmu:14824); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;12524533;12526812;1618805;20026663;21092856;21750661;23041626;26370502;27789271;28073925;28453791;28541286;28728022;28835281;29562282;31616917;32761777;32852886;32929860;34428180;34887587;35820727;37453647;8471244;8482392;8496151", "class_list": "", "function": "Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12524533, PubMed:20026663, PubMed:23041626, PubMed:27789271, PubMed:28073925, PubMed:28453791, PubMed:28541286, PubMed:8496151). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:27789271, PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (PubMed:12524533). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:8496151). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:20026663, PubMed:23041626)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 15, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0060179 male mating behavior;GO:1903979 negative regulation of microglial cell activation;GO:1903334 positive regulation of protein folding;GO:0002265 astrocyte activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P28798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35930-1", "uniprot_id": "GP1BA_MOUSE", "mass": 80055.0, "length": 734, "protein_name": "Platelet glycoprotein Ib alpha chain", "gene_name": "Gp1ba", "organism": "Mouse", "refseq_name": "platelet glycoprotein Ib alpha chain precursor", "refseq_ac": "NP_001418327", "gene_names_uniprotkb": "Gp1ba", "gene_names_refseq": "GP-Ib alpha; GPIbalpha; GPIba; Gp1ba", "protein_names_uniprotkb": "Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha", "protein_names_refseq": "glycoprotein Ibalpha; platelet glycoprotein Ib alpha chain precursor; platelet glycoprotein Ib alpha chain", "tax_id": 10090, "disease": "non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); platelet-type bleeding disorder 3 (Disease Ontology:DOID:0111056); Bernard-Soulier syndrome type A2 (Disease Ontology:DOID:0111059); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); peritoneum cancer (Disease Ontology:DOID:1725); Bernard-Soulier syndrome (Disease Ontology:DOID:2217); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:14723); (R-MMU-430116); (R-MMU-76009); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11858495;12907434;30084848;39627609;9410473", "class_list": "", "function": "GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium., [UniProtKB]", "predicted_glycosites": 23, "predicted_n_glycosites": 0, "predicted_o_glycosites": 23, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q5SX47", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:1990779 glycoprotein Ib-IX-V complex", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54792-1", "uniprot_id": "HES2_MOUSE", "mass": 17259.0, "length": 157, "protein_name": "Transcription factor HES-2", "gene_name": "Hes2", "organism": "Mouse", "refseq_name": "transcription factor HES-2", "refseq_ac": "NP_001288734", "gene_names_uniprotkb": "Hes2", "gene_names_refseq": "HES-2; Hes2", "protein_names_uniprotkb": "Transcription factor HES-2; Hairy and enhancer of split 2", "protein_names_refseq": "hairy and enhancer of split 2; transcription factor HES-2", "tax_id": 10090, "disease": "central nervous system cancer (Disease Ontology:DOID:3620)", "pathway": " (mmu:15206)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24015274;9570950", "class_list": "", "function": "The protein encoded by this gene belongs to the mammalian Hes gene family, the mammalian homologues of Drosophila hairy and Enhancer of split. Hes 2 is a basic helix-loop-helix transcriptional repressor and is an effector of the Notch signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]; The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor of genes that require a bHLH protein for their transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKA6", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O54792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02088-1", "uniprot_id": "HBB1_MOUSE", "mass": 15840.0, "length": 147, "protein_name": "Hemoglobin subunit beta-1", "gene_name": "Hbb-b1", "organism": "Mouse", "refseq_name": "hemoglobin subunit beta-1", "refseq_ac": "NP_001265090", "gene_names_uniprotkb": "Hbb-b1", "gene_names_refseq": "AA409645; Hbb-b1; Hbb1; Hbbt1; Hbbt2; MommeD7; MommeD; beta1", "protein_names_uniprotkb": "Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta-1 chain; Hemoglobin beta-major chain", "protein_names_refseq": "beta major globin; hemoglobin subunit beta-1", "tax_id": 10090, "disease": "autosomal dominant beta thalassemia (Disease Ontology:DOID:0080770); delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell disease (Disease Ontology:DOID:0081445); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 6 (Disease Ontology:DOID:0111632); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Parkinson's disease (Disease Ontology:DOID:14330); acute chest syndrome (Disease Ontology:DOID:1584); anemia (Disease Ontology:DOID:2355); hemoglobin C disease (Disease Ontology:DOID:2859); hemoglobinopathy (Disease Ontology:DOID:2860); congenital hemolytic anemia (Disease Ontology:DOID:589); polycythemia (Disease Ontology:DOID:8432)", "pathway": " (mmu:100503605); (mmu:101488143); (mmu:15129)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10441738;11747442;17242355;21183079;23806337;25428506;264241;273235;277329;2926808;31219806;32152506;34428180;35984892;36288343;36583994;37453647;37828378;3870864;39627609;482942;519759;999642", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]; This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-major adult gene found in the 'diffuse' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54AI0;Q91V86;Q9CRZ2;Q9CXH5;Q9CY12;Q9CY54;Q9R0S6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0030492 hemoglobin binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043209 myelin sheath;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0030097 hemopoiesis;GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0098869 cellular oxidant detoxification;GO:0010999 regulation of eIF2 alpha phosphorylation by heme", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P02088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04230-1", "uniprot_id": "HB21_MOUSE", "mass": 30166.0, "length": 264, "protein_name": "H-2 class II histocompatibility antigen, E-B beta chain", "gene_name": "H2-Eb1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Eb1", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, E-B beta chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); stroke (Disease Ontology:DOID:0051061); latex allergy (Disease Ontology:DOID:0060532); lupus nephritis (Disease Ontology:DOID:0080162); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); sensorineural hearing loss (Disease Ontology:DOID:10003); leprosy (Disease Ontology:DOID:1024); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); Alport syndrome (Disease Ontology:DOID:10983); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); sarcoidosis (Disease Ontology:DOID:11335); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); sympathetic ophthalmia (Disease Ontology:DOID:12029); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); Chagas disease (Disease Ontology:DOID:12140); alveolar echinococcosis (Disease Ontology:DOID:12148); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); paracoccidioidomycosis (Disease Ontology:DOID:12662); autistic disorder (Disease Ontology:DOID:12849); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); temporal arteritis (Disease Ontology:DOID:13375); pure red-cell aplasia (Disease Ontology:DOID:1340); uveoparotid fever (Disease Ontology:DOID:13404); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Addison's disease (Disease Ontology:DOID:13774); polyneuropathy (Disease Ontology:DOID:1389); schistosomiasis (Disease Ontology:DOID:1395); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); urticaria (Disease Ontology:DOID:1555); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); breast carcinoma (Disease Ontology:DOID:3459); mixed connective tissue disease (Disease Ontology:DOID:3492); cerebral infarction (Disease Ontology:DOID:3526); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); autoimmune disease (Disease Ontology:DOID:417); myasthenia gravis (Disease Ontology:DOID:437); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); neuromyelitis optica (Disease Ontology:DOID:8869); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); narcolepsy (Disease Ontology:DOID:8986); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); allergic asthma (Disease Ontology:DOID:9415); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (mmu:14969); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-2132295); (R-MMU-389948)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;14690592;17051151;17174123;1855817;1918991;21750661;24788674;29187734;2986145;3018929;3150763;34428180;3692165;37828378;3980466;6086309", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 95, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O78226", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0042609 CD4 receptor binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0042613 MHC class II protein complex;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002250 adaptive immune response;GO:0034341 response to type II interferon;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0050870 positive regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P04230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10853-1", "uniprot_id": "H2B1F_MOUSE", "mass": 13936.0, "length": 126, "protein_name": "Histone H2B type 1-F/J/L", "gene_name": "H2bc11; H2bc13; H2bc15; H2bc7", "organism": "Mouse", "refseq_name": "histone H2B type 1-F/J/L", "refseq_ac": "NP_835502", "gene_names_uniprotkb": "H2bc11; H2bc13; H2bc15; H2bc7; H2b-f; H2b-j; H2b-l; H2b-n; Hist1h2bf; Hist1h2bj; Hist1h2bl; Hist1h2bn", "gene_names_refseq": "H2bc11; H2bc13; H2bc15; H2bc7; Hist1h2bf", "protein_names_uniprotkb": "Histone H2B type 1-F/J/L; H2B 291A", "protein_names_refseq": "H2B 291A; histone 1, H2bf; histone H2B type 1-F/J/L; histone cluster 1, H2bf", "tax_id": 10090, "disease": "", "pathway": " (mmu:319180); (mmu:319183); (mmu:319185); (mmu:319187); (mmu:665596); (mmu:665622); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 21, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;22645316;24681537;25605945;27105115;28528544;30154464;31219806;31645732;32822587;33219380;34887587;3562244;36288343;39927985;8858344", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZZ3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa;GO:0061644 protein localization to CENP-A containing chromatin", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P10853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14430-1", "uniprot_id": "HA18_MOUSE", "mass": 37411.0, "length": 326, "protein_name": "H-2 class I histocompatibility antigen, Q8 alpha chain", "gene_name": "H2-Q8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Q8", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, Q8 alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "25605945;3004940;30084848", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P14430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20060-1", "uniprot_id": "HEXB_MOUSE", "mass": 61116.0, "length": 536, "protein_name": "Beta-hexosaminidase subunit beta", "gene_name": "Hexb", "organism": "Mouse", "refseq_name": "beta-hexosaminidase subunit beta precursor", "refseq_ac": "NP_034552", "gene_names_uniprotkb": "Hexb", "gene_names_refseq": "Hexb", "protein_names_uniprotkb": "Beta-hexosaminidase subunit beta; 3.2.1.52; Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta", "protein_names_refseq": "N-acetyl-beta-glucosaminidase subunit beta; beta-N-acetylhexosaminidase subunit beta; beta-hexosaminidase subunit beta precursor; beta-hexosaminidase subunit beta; hexosaminidase subunit B", "tax_id": 10090, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); lysosomal storage disease (Disease Ontology:DOID:3211); Sandhoff disease (Disease Ontology:DOID:3323)", "pathway": " (mmu:15212); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-2160916); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;25428506;26495903;26740625;2971567;30084848;30779550;30899004;31219806;33300544;34203471;34428180;36210013;36852467;37828378;40885482;7918686;7959736;8253842", "class_list": "glycogene;glycosylhydrolase", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (PubMed:8253842)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0044877 protein-containing complex binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0001669 acrosomal vesicle;GO:0042582 azurophil granule", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006689 ganglioside catabolic process;GO:0008049 male courtship behavior;GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P20060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64525-1", "uniprot_id": "H2B2B_MOUSE", "mass": 13920.0, "length": 126, "protein_name": "Histone H2B type 2-B", "gene_name": "H2bc18", "organism": "Mouse", "refseq_name": "histone H2B type 2-B", "refseq_ac": "NP_783597", "gene_names_uniprotkb": "H2bc18; Hist2h2bb", "gene_names_refseq": "H2b-616; H2bc18; Hist2h2bb", "protein_names_uniprotkb": "Histone H2B type 2-B; H2B-clustered histone 18; H2b-616", "protein_names_refseq": "H2b 616; histone 2, H2bb; histone H2B type 2-B; histone cluster 2, H2bb", "tax_id": 10090, "disease": "", "pathway": " (mmu:319189); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8866654); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 21, "publication_count": 19, "publication_id_list": "12408966;15197225;16039583;17690254;20647423;21925322;22389435;22967069;23240083;23806337;24681537;27105115;30154464;31645732;32822587;33300544;33725478;35820727;8858345", "class_list": "", "function": "Autoimmunity to isoAsp H2B suggests that this form of the autoantigen may be critical in the induction of anti-histone autoantibodies in murine models of human SLE., [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; H2B plays a very prominent and functionally important role as plasminogen receptor., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Aug 2015]., [RefSeq]; The activity-dependent histone variant H2BE modulates the life span of olfactory neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q64525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZC8-1", "uniprot_id": "GPAM1_MOUSE", "mass": 38955.0, "length": 346, "protein_name": "GPALPP motifs-containing protein 1", "gene_name": "Gpalpp1", "organism": "Mouse", "refseq_name": "GPALPP motifs-containing protein 1", "refseq_ac": "NP_080453", "gene_names_uniprotkb": "Gpalpp1; Kiaa1704", "gene_names_refseq": "1200011I18Rik; Gpalpp1; Kiaa1704", "protein_names_uniprotkb": "GPALPP motifs-containing protein 1", "protein_names_refseq": "GPALPP motifs-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67467)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15345747;17242355;19131326;19144319;21183079;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2V8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q69ZC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFV5-1", "uniprot_id": "HELZ_MOUSE", "mass": 219880.0, "length": 1964, "protein_name": "ATP-dependent RNA helicase with zinc finger domain", "gene_name": "Helz", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase with zinc finger domain isoform 1", "refseq_ac": "NP_938040", "gene_names_uniprotkb": "Helz; Kiaa0054", "gene_names_refseq": "3110078M01Rik; 9430093I07Rik; 9630002H22Rik; DRHC; Helz", "protein_names_uniprotkb": "ATP-dependent RNA helicase with zinc finger domain; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase with zinc finger domain isoform 1; ATP-dependent RNA helicase with zinc finger domain; probable helicase with zinc finger domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:78455)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "17242355;18250455;20305823;21183079;21750661;21765940;25428506;25428507;25605945;30059200;30084848;31219806;32782141;32848054;34043986;34428180;35820727;35822049;36852467;37828378;39927985;40885482", "class_list": "", "function": "ATP-dependent RNA helicase that promotes degradation of mRNAs via its association with the CCR4-NOT deadenylase complex, leading to deadenylation, decapping, and subsequent degradation of target mRNAs. Can repress translation independently of mRNA decay in a manner dependent on both the CCR4-NOT complex and the helicase DDX6. Involved in promoting cell proliferation, translation initiation, and ribosomal protein S6 (RPS6) phosphorylation., [UniProtKB, UniProtKB]; CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart., [RefSeq, PubMed]; Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6., [RefSeq, PubMed]; Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1L4L4;A2AAU4;Q8BZZ6;Q8CHI3;Q8VDI3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0017148 negative regulation of translation;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q6DFV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TL19-1", "uniprot_id": "GUC2G_MOUSE", "mass": 122546.0, "length": 1100, "protein_name": "Guanylate cyclase 2G", "gene_name": "Gucy2g", "organism": "Mouse", "refseq_name": "guanylate cyclase 2G isoform 1 precursor", "refseq_ac": "NP_001074545", "gene_names_uniprotkb": "Gucy2g", "gene_names_refseq": "2410077I05Rik; GC-G; Gucy2g", "protein_names_uniprotkb": "Guanylate cyclase 2G; 4.6.1.2; Guanylyl cyclase receptor G; mGC-G", "protein_names_refseq": "guanylate cyclase 2G isoform 1 precursor; guanylyl cyclase receptor G", "tax_id": 10090, "disease": "", "pathway": " (mmu:73707)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14713286;16857755;25452496;36210013", "class_list": "", "function": "Cloning of a guanylate cyclase receptor, GC-G, that is selective expressed in the testis [GC-G], [RefSeq, PubMed]; It was observed that dimerization/oligomerization of GC-G, a process generally considered as critical for enzymatic activity of GCs, is strongly enhanced by coolness., [RefSeq, PubMed]; MGC-G is a sperm cell surface protein that possibly functions in early signaling event regulating calcium influx/efflux and sperm motility., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWU7", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TL19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK58-1", "uniprot_id": "HBAP1_MOUSE", "mass": 54395.0, "length": 483, "protein_name": "HSPB1-associated protein 1", "gene_name": "Hspbap1", "organism": "Mouse", "refseq_name": "HSPB1-associated protein 1", "refseq_ac": "NP_780320", "gene_names_uniprotkb": "Hspbap1; Pass1", "gene_names_refseq": "3830421G21Rik; Hspbap1", "protein_names_uniprotkb": "HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1", "protein_names_refseq": "27 KdA heat shock protein-associated protein 1; HSPB1-associated protein 1; protein associated with small stress protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66667)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10751411;21750661;28528544;34428180;35820727", "class_list": "", "function": "May play a role in cellular stress response., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QML8", "ec_number_list": "", "go_molecular_function": "GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BK58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMF5-1", "uniprot_id": "GRIK4_MOUSE", "mass": 107264.0, "length": 956, "protein_name": "Glutamate receptor ionotropic, kainate 4", "gene_name": "Grik4", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, kainate 4 precursor", "refseq_ac": "NP_780690", "gene_names_uniprotkb": "Grik4", "gene_names_refseq": "6330551K01Rik; GluK4; GluRgamma1; Grik4; KA-1; KA1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 4; GluK4; Glutamate receptor KA-1; KA1", "protein_names_refseq": "glutamate receptor KA-1; glutamate receptor KA1; glutamate receptor ionotropic, kainate 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:110637); (R-MMU-451308)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12954862;35820727", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "E9QNA2", "ec_number_list": "", "go_molecular_function": "GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BMF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BR93-1", "uniprot_id": "HARB1_MOUSE", "mass": 38713.0, "length": 349, "protein_name": "Putative nuclease HARBI1", "gene_name": "Harbi1", "organism": "Mouse", "refseq_name": "putative nuclease HARBI1 isoform a", "refseq_ac": "NP_848839", "gene_names_uniprotkb": "Harbi1", "gene_names_refseq": "D230010M03Rik; Harbi1", "protein_names_uniprotkb": "Putative nuclease HARBI1; 3.1.-.-; Harbinger transposase-derived nuclease", "protein_names_refseq": "harbinger transposase-derived nuclease; putative nuclease HARBI1 isoform a; putative nuclease HARBI1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241547)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15169610;21750661", "class_list": "", "function": "Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH19;B7ZCF8;Q8BNA8;Q8BNT1;Q8C9N1", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BR93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI52-1", "uniprot_id": "ASTRC_MOUSE", "mass": 76009.0, "length": 662, "protein_name": "Protein Aster-C", "gene_name": "Gramd1c", "organism": "Mouse", "refseq_name": "protein Aster-C isoform 1", "refseq_ac": "NP_001165578", "gene_names_uniprotkb": "Gramd1c", "gene_names_refseq": "4921521N14Rik; Gramd1c", "protein_names_uniprotkb": "Protein Aster-C; GRAM domain-containing protein 1C", "protein_names_refseq": "GRAM domain-containing protein 1C; protein Aster-C isoform 1; protein Aster-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:207798)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30220461;34428180;35820727", "class_list": "", "function": "Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1SSU1;Q8BI24", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site;GO:0016020 membrane", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CI52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZX2-1", "uniprot_id": "HAUS3_MOUSE", "mass": 66308.0, "length": 570, "protein_name": "HAUS augmin-like complex subunit 3", "gene_name": "Haus3", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 3", "refseq_ac": "NP_666271", "gene_names_uniprotkb": "Haus3", "gene_names_refseq": "D4S43h; D5H4S43E; D5H4S43; Haus3", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 3", "protein_names_refseq": "HAUS augmin-like complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:231123); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "20173027;21750661;21952136;25428506;25605945;27802388;30084848;30779550;34428180;35820727;36210013;37828378", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSW5;Q8BQL2;Q8CIH1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly;GO:0031023 microtubule organizing center organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8QZX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQ21-1", "uniprot_id": "HEPC_MOUSE", "mass": 9352.0, "length": 83, "protein_name": "Hepcidin", "gene_name": "Hamp", "organism": "Mouse", "refseq_name": "hepcidin preproprotein", "refseq_ac": "NP_115930", "gene_names_uniprotkb": "Hamp; Hamp1; Hepc1; Hepc", "gene_names_refseq": "Hamp1; Hamp; Hepc1; Hepc", "protein_names_uniprotkb": "Hepcidin", "protein_names_refseq": "hepcidin antimicrobial peptide 1; hepcidin preproprotein", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 2B (Disease Ontology:DOID:0111032); iron deficiency anemia (Disease Ontology:DOID:11758); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); pure red-cell aplasia (Disease Ontology:DOID:1340); extrahepatic cholestasis (Disease Ontology:DOID:13619); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:84506)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11113132;11447267;12370282;12729891;15124018;24880340;30084848;34428180;37585449;37762679;38195497;39278061", "class_list": "", "function": "A Decrease in Maternal Iron Levels Is the Predominant Factor Suppressing Hepcidin during Pregnancy in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes., [UniProtKB, PubMed, PubMed]; P. Gingivalis induce macrophage polarization by regulating hepcidin expression in chronic apical periodontitis., [RefSeq, PubMed]; Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0005507 copper ion binding;GO:0097690 iron ion transmembrane transporter inhibitor activity;GO:0141108 transporter regulator activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0014704 intercalated disc", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:2000646 positive regulation of receptor catabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EQ21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHE6-1", "uniprot_id": "HES6_MOUSE", "mass": 24454.0, "length": 224, "protein_name": "Transcription cofactor HES-6", "gene_name": "Hes6", "organism": "Mouse", "refseq_name": "transcription cofactor HES-6 isoform 1", "refseq_ac": "NP_062352", "gene_names_uniprotkb": "Hes6", "gene_names_refseq": "Hes6; bHLHb41", "protein_names_uniprotkb": "Transcription cofactor HES-6; Hairy and enhancer of split 6", "protein_names_refseq": "transcription cofactor HES-6 isoform 1; transcription cofactor HES-6", "tax_id": 10090, "disease": "coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:55927)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10851137;10906477;11044617;30779550;34428180", "class_list": "", "function": "Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2D7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJC9-1", "uniprot_id": "HERP2_MOUSE", "mass": 44501.0, "length": 404, "protein_name": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "gene_name": "Herpud2", "organism": "Mouse", "refseq_name": "homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "refseq_ac": "NP_065611", "gene_names_uniprotkb": "Herpud2; MNCb-2040", "gene_names_refseq": "5031400M07Rik; Herpud2", "protein_names_uniprotkb": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "protein_names_refseq": "homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:80517)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;30084848;30679156;30779550;34428180", "class_list": "", "function": "Could be involved in the unfolded protein response (UPR) pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2W2;Q9CSZ4;Q9D2D0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NYQ2-1", "uniprot_id": "HAOX2_MOUSE", "mass": 38700.0, "length": 353, "protein_name": "2-Hydroxyacid oxidase 2", "gene_name": "Hao2", "organism": "Mouse", "refseq_name": "2-Hydroxyacid oxidase 2", "refseq_ac": "NP_062418", "gene_names_uniprotkb": "Hao2; Hao3; Haox2", "gene_names_refseq": "Hao-2; Hao2; Hao3; Haox3", "protein_names_uniprotkb": "2-Hydroxyacid oxidase 2; (S)-2-hydroxy-acid oxidase, peroxisomal; 1.1.3.15; HAOX2; Medium chain alpha-hydroxy acid oxidase; Medium-chain L-2-hydroxy acid oxidase", "protein_names_refseq": "(S)-2-hydroxy-acid oxidase, peroxisomal; 2-Hydroxyacid oxidase 2; HAOX2; hydroxyacid oxidase (glycolate oxidase) 3; hydroxyacid oxidase 2, kidney; medium chain alpha-hydroxy acid oxidase; medium-chain 2-hydroxy acid oxidase HAOX3; medium-chain L-2-hydroxy acid oxidase", "tax_id": 10090, "disease": "", "pathway": " (mmu:56185); (R-MMU-390918); (R-MMU-9033241)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10777549;21183079", "class_list": "", "function": "Oxidase that catalyzes the oxidation of medium chain hydroxyacids such as 2-hydroxyoctanoate, to the corresponding 2-oxoacids. Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate, 2-hydroxybutanoate and 2-hydroxyhexadecanoate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHS7;Q9JI00", "ec_number_list": "2.3.2.27;5.1.99.4;2.6.1.51;2.6.1.44;5.3.3.21;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.1.2.-;3.1.2.2;1.1.1.42;3.6.1.-;3.6.1.77;1.4.3.3;1.11.1.6;1.14.13.39;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;2.3.1.137;2.3.1.7;2.3.2.36;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.1.42;1.5.3.13;2.3.1.65;1.4.3.1;4.1.1.9;1.1.1.300;1.1.1.184;1.3.1.38;1.5.3.1;1.5.3.7;3.4.21.-;3.4.21.53;2.5.1.18;1.3.3.6;3.4.24.56;1.1.3.15;4.1.2.63;1.2.3.5;5.3.3.8;1.3.1.124", "go_molecular_function": "GO:0042802 identical protein binding;GO:0010181 FMN binding;GO:0003973 (S)-2-hydroxy-acid oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0018924 mandelate metabolic process;GO:0019395 fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9NYQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1M0-1", "uniprot_id": "HMCES_MOUSE", "mass": 40169.0, "length": 353, "protein_name": "Abasic site processing protein HMCES", "gene_name": "Hmces", "organism": "Mouse", "refseq_name": "abasic site processing protein HMCES isoform a", "refseq_ac": "NP_776098", "gene_names_uniprotkb": "Hmces; Srap1; Srapd1", "gene_names_refseq": "8430410A17Rik; Hmces; Srap1", "protein_names_uniprotkb": "Abasic site processing protein HMCES; 3.4.-.-; 4.-.-.-; ES cell-specific 5hmC-binding protein; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Peptidase HMCES; SRAP domain-containing protein 1", "protein_names_refseq": "ES cell-specific 5hmC-binding protein; SRAP domain-containing protein 1; UPF0361 protein C3orf37 homolog; abasic site processing protein HMCES isoform a; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; peptidase HMCES; putative endonuclease HMCES; putative peptidase SRAPD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:232210)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;23434322;25471351;27097670;29020633;31806351;35450882", "class_list": "", "function": "Correlation analyses showed that 5hmC enrichment in gene body is positively associated with gene expression level in mouse kidney. Moreover, ischemia reperfusion (IR) injury-associated genes (both up- and down-regulated genes during renal IR injury) in mouse kidney exhibit significantly higher 5hmC enrichment in their gene body regions when compared to those un-changed genes., [RefSeq, PubMed]; Further evidence for a specialized role for HMCES in DNA repair. Erratum:[Mol Cell. 2020 Mar 5;77(5):1154. doi: 10.1016/j.molcel.2020.02.008. PMID: 32142687], [RefSeq, PubMed]; HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation., [RefSeq, PubMed]; Inactivation of murine Srap1 results in accumulation of 5hmC in genomic DNA. Srap1 deficient mice display embryonic sublethality and altered DNA methylation., [RefSeq, PubMed]; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (By similarity). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (By similarity). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). The HMCES DNA-protein cross-link is then either reversed or degraded (By similarity). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (By similarity). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (By similarity). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (PubMed:31806351). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (PubMed:29020633)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The findings of this study described in this study emphasise the importance of 5hmC in brain development and ageing and will help to better understand the complexity and plasticity of the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008233 peptidase activity;GO:0003697 single-stranded DNA binding;GO:0140431 DNA-(abasic site) binding;GO:0160129 protein-DNA covalent cross-linking activity", "go_cellular_component": "GO:0005657 replication fork", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R1M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESB3-1", "uniprot_id": "HRG_MOUSE", "mass": 59163.0, "length": 525, "protein_name": "Histidine-rich glycoprotein", "gene_name": "Hrg", "organism": "Mouse", "refseq_name": "histidine-rich glycoprotein precursor", "refseq_ac": "NP_444406", "gene_names_uniprotkb": "Hrg", "gene_names_refseq": "D16jh2; D18020; Hprg; Hrgp; Hrg", "protein_names_uniprotkb": "Histidine-rich glycoprotein; HPRG; Histidine-proline-rich glycoprotein", "protein_names_refseq": "histidine-proline-rich glycoprotein; histidine-rich glycoprotein precursor", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to HRG deficiency (Disease Ontology:DOID:0111903); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (mmu:94175); (R-MMU-114608); (R-MMU-75205); (R-MMU-9855719)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10849117;15220341;15499407;15748999;15869579;17330941;18797515;19903770;21264222;21750661;22374984;26495903;30084848;31211768;36288343;38469298;38605050;39627609", "class_list": "", "function": "CD36 mediates the antiangiogenic effect of thrombospondin-2, which is modulated by histidine-rich glycoprotein, [RefSeq, PubMed]; HRG acts as a soluble adaptor molecule that binds to cells at sites of tissue injury, tumor growth, and angiogenesis, [RefSeq, PubMed]; HRG plays a role as both an anticoagulant and an antifibrinolytic modifier, and may regulate platelet function in vivo, [RefSeq, PubMed]; Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Other HBPs such as alpha 2-HS glycoprotein (AHSG) and histidine-rich glycoprotein (HRG) need further investigation for potential applications in the management of Acute pancreatitis (AP) . Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP. Publication Status: Online-Only, [RefSeq, PubMed]; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis (By similarity). Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6YK32;Q6YKA2;Q99PS5;Q99PS6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:2000504 positive regulation of blood vessel remodeling;GO:0010543 regulation of platelet activation;GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9ESB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P31-1", "uniprot_id": "HPBP1_MOUSE", "mass": 39167.0, "length": 357, "protein_name": "Hsp70-binding protein 1", "gene_name": "Hspbp1", "organism": "Mouse", "refseq_name": "hsp70-binding protein 1", "refseq_ac": "NP_077134", "gene_names_uniprotkb": "Hspbp1; Hspbp", "gene_names_refseq": "1500019G21Rik; Hspbp1", "protein_names_uniprotkb": "Hsp70-binding protein 1; Heat shock protein-binding protein 1; Hsp70-interacting protein 1; HspBP1", "protein_names_refseq": "SPA) binding protein, cytoplasmic cochaperone 1; heat shock protein-binding protein 1; hsp70-binding protein 1; hsp70-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66245)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15665051;21183079;21750661;24899640;32782141;35820727", "class_list": "", "function": "Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Male HSPBP1knockout mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes., [RefSeq, PubMed]; Provides a critical cardioprotective effect in the setting of ischemia-reperfusion injury due in part to increased apoptosis in cardiac cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYV8", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0000774 adenyl-nucleotide exchange factor activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99P31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WM5-1", "uniprot_id": "HPLN3_MOUSE", "mass": 40740.0, "length": 359, "protein_name": "Hyaluronan and proteoglycan link protein 3", "gene_name": "Hapln3", "organism": "Mouse", "refseq_name": "hyaluronan and proteoglycan link protein 3 precursor", "refseq_ac": "NP_839986", "gene_names_uniprotkb": "Hapln3; Lpr3", "gene_names_refseq": "4930554N11Rik; Hapln3; Lpr3", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 3", "protein_names_refseq": "hyaluronan and proteoglycan link protein 3 precursor; link protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67666)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12663660;21750661", "class_list": "glycogene", "function": "May function in hyaluronic acid binding., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVT2;Q80XX3", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net;GO:0140150 gel phase of interstitial matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X72-1", "uniprot_id": "HEMO_MOUSE", "mass": 51318.0, "length": 460, "protein_name": "Hemopexin", "gene_name": "Hpx", "organism": "Mouse", "refseq_name": "hemopexin precursor", "refseq_ac": "NP_059067", "gene_names_uniprotkb": "Hpx; Hpxn", "gene_names_refseq": "Hpxn; Hpx; hx", "protein_names_uniprotkb": "Hemopexin", "protein_names_refseq": "hemopexin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:15458); (R-MMU-2168880)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12393471;16944957;17330941;18556779;21750661;26495903;26740625;28011936;31219806;31361958;34428180;34658156;35984892;36288343;37507081;37899696;39627609;39927985", "class_list": "", "function": "Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation., [UniProtKB]; Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia., [RefSeq, PubMed]; Haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis, [RefSeq, PubMed]; Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease., [RefSeq, PubMed]; The importance of hemopexin in heme detoxification, thus suggesting that drugs mimicking hemopexin activity might be useful to prevent endothelial damage in patients suffering from hemolytic disorders., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P97824;Q3UKP2;Q8WUP0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006879 intracellular iron ion homeostasis;GO:0020027 hemoglobin metabolic process;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q91X72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1K9-1", "uniprot_id": "HINFP_MOUSE", "mass": 58076.0, "length": 503, "protein_name": "Histone H4 transcription factor", "gene_name": "Hinfp", "organism": "Mouse", "refseq_name": "histone H4 transcription factor", "refseq_ac": "NP_751894", "gene_names_uniprotkb": "Hinfp; Mizf", "gene_names_refseq": "HiNF-P; Hinfp; Mizf", "protein_names_uniprotkb": "Histone H4 transcription factor; HiNF-P; Histone nuclear factor P; MBD2-interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein", "protein_names_refseq": "MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein; MBD2-interacting zinc finger protein; histone H4 transcription factor; histone nuclear factor P; methyl-CpG-binding protein 2-interacting zinc finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:102423)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17826007;21605641;21750661;24797072;26030398;27609454;34428180", "class_list": "", "function": "Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage., [RefSeq, PubMed]; Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression., [RefSeq, PubMed]; Simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation., [RefSeq, PubMed]; The dependence of HiNF-P gene transcription on cyclin E/CDK2/p220NPAT signaling defines a novel feed-forward loop that may sustain HiNF-P expression in proliferating cells to support the cell cycle regulated synthesis of histone H4 proteins., [RefSeq, PubMed]; The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development., [RefSeq, PubMed]; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPQ4;Q8BWY0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015030 Cajal body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K1K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RT60-1", "uniprot_id": "HTRA4_MOUSE", "mass": 51988.0, "length": 483, "protein_name": "Serine protease HTRA4", "gene_name": "Htra4", "organism": "Mouse", "refseq_name": "serine protease HTRA4 precursor", "refseq_ac": "NP_001074656", "gene_names_uniprotkb": "Htra4", "gene_names_refseq": "B430206E18Rik; Htra4", "protein_names_uniprotkb": "Serine protease HTRA4; 3.4.21.-; High-temperature requirement factor A4", "protein_names_refseq": "high-temperature requirement factor A4; serine protease HTRA4 precursor; serine protease HTRA4", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:330723)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;26353049", "class_list": "", "function": "Mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia., [RefSeq, PubMed]; Serine protease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2RT60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RXB2-1", "uniprot_id": "HSBPL_MOUSE", "mass": 8101.0, "length": 72, "protein_name": "Heat shock factor-binding protein 1-like protein 1", "gene_name": "Hsbp1l1", "organism": "Mouse", "refseq_name": "heat shock factor-binding protein 1-like protein 1", "refseq_ac": "NP_001129653", "gene_names_uniprotkb": "Hsbp1l1", "gene_names_refseq": "1810005K13Rik; Hsbp1l1", "protein_names_uniprotkb": "Heat shock factor-binding protein 1-like protein 1", "protein_names_refseq": "heat shock factor-binding protein 1-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66255)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0070370 cellular heat acclimation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RXB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35310-1", "uniprot_id": "HS3S1_MOUSE", "mass": 35899.0, "length": 311, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 1", "gene_name": "Hs3st1", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor", "refseq_ac": "NP_034604", "gene_names_uniprotkb": "Hs3st1; 3ost1; 3ost", "gene_names_refseq": "3-Ost; D5Wsu110e; Hs3st1; Hsg3ost", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 1; 2.8.2.23; Heparan sulfate 3-O-sulfotransferase 1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1", "protein_names_refseq": "heparan sulfate 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:15476); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11006120;15060080;21750661;9346953", "class_list": "glycogene", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:15060080, PubMed:9346953). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:15060080, PubMed:9346953). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:15060080, PubMed:9346953)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YGZ1-1", "uniprot_id": "HPSE_MOUSE", "mass": 60066.0, "length": 535, "protein_name": "Heparanase", "gene_name": "Hpse", "organism": "Mouse", "refseq_name": "heparanase preproprotein", "refseq_ac": "NP_690016", "gene_names_uniprotkb": "Hpse; Hpa", "gene_names_refseq": "HSE1; Hpa; Hpr1; Hpse", "protein_names_uniprotkb": "Heparanase; 3.2.1.166; Endo-glucoronidase", "protein_names_refseq": "endo-glucoronidase; endoglycosidase heparanase; heparanase preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:15442); (R-MMU-2024096); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10395326;12460766;12837765;14618334;15677344;15793281;17689495;18589009;21750661;38378682;38581737", "class_list": "glycogene;glycosylhydrolase", "function": "A full-length heparanase gene was cloned from a mouse embryo cDNA library and determined to encode a protein of 535 amino acids. The full-length mouse gene was stably expressed in NS0 myeloma cells., [RefSeq, PubMed]; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Expression of heparanase mRNA and VEGF, and vessel formation in mouse fractured bone, [RefSeq, PubMed]; Heparanase promotes the onset and progression of atherosclerosis in apolipoprotein E gene knockout mice., [RefSeq, PubMed]; Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RS99;Q8K3K3", "ec_number_list": "3.2.1.18;3.4.24.34;3.4.22.15;3.4.21.-;3.2.1.17;3.4.23.5;3.1.3.48;3.6.5.2;3.4.21.37;3.5.3.1;3.2.1.166;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.7.10.2;2.3.2.5;3.1.21.-;3.2.1.14;3.5.1.3;3.4.18.1;3.4.19.9", "go_molecular_function": "GO:0045545 syndecan binding;GO:0030305 heparanase activity;GO:0140355 cargo receptor ligand activity;GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005768 endosome", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6YGZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70252-1", "uniprot_id": "HMOX2_MOUSE", "mass": 35739.0, "length": 315, "protein_name": "Heme oxygenase 2", "gene_name": "Hmox2", "organism": "Mouse", "refseq_name": "heme oxygenase 2 isoform 1", "refseq_ac": "NP_001129538", "gene_names_uniprotkb": "Hmox2", "gene_names_refseq": "HO-2; HO2; Hmox2", "protein_names_uniprotkb": "Heme oxygenase 2; 1.14.14.18; HO-2", "protein_names_refseq": "heme oxygenase (decycling) 2; heme oxygenase 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15369); (R-MMU-189483); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-917937); (R-MMU-9707564)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26495903;28528544;34428180;37480265;37844118;9795203", "class_list": "", "function": "Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos., [RefSeq, PubMed]; Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70626", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.1.2.-;7.6.2.-;3.6.5.2;1.1.1.-;3.6.4.-;2.7.11.13;2.7.11.39;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0042167 heme catabolic process;GO:0006788 heme oxidation;GO:0010106 cellular response to iron ion starvation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O70252-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8M3-1", "uniprot_id": "HRG1_MOUSE", "mass": 16489.0, "length": 146, "protein_name": "Heme transporter HRG1", "gene_name": "Slc48a1", "organism": "Mouse", "refseq_name": "heme transporter HRG1", "refseq_ac": "NP_080629", "gene_names_uniprotkb": "Slc48a1; Hrg1", "gene_names_refseq": "4930570C03Rik; Slc48a1", "protein_names_uniprotkb": "Heme transporter HRG1; HRG-1; Heme-responsive gene 1 protein homolog; Solute carrier family 48 member 1", "protein_names_refseq": "heme transporter HRG1; heme-responsive gene 1 protein homolog; solute carrier family 48 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67739)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23395172;30084848;34713217", "class_list": "", "function": "Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP)., [UniProtKB, PubMed, PubMed]; These results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU69;Q9DCK0", "ec_number_list": "", "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0061474 phagolysosome membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0015886 heme transport;GO:0042168 heme metabolic process;GO:0097037 heme export;GO:0140357 heme export from vacuole to cytoplasm", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D8M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3H7-1", "uniprot_id": "HS2ST_MOUSE", "mass": 41813.0, "length": 356, "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "gene_name": "Hs2st1", "organism": "Mouse", "refseq_name": "heparan sulfate 2-O-sulfotransferase 1 isoform 2", "refseq_ac": "NP_035958", "gene_names_uniprotkb": "Hs2st1; Hs2st", "gene_names_refseq": "2OST; Hs2st1; Hs2st; mKIAA0448", "protein_names_uniprotkb": "Heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; 2-OST; 2.8.2.-; 2OST; HS 2-O-sulfotransferase; Heparan sulfate 2-sulfotransferase", "protein_names_refseq": "2-O-sulfotransferase; HS 2-O-sulfotransferase; heparan sulfate 2-O-sulfotransferase 1 isoform 2; heparan sulfate 2-sulfotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:23908); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10677367;11331020;11457822;11687650;18250455;21750661;25428506;25605945;30084848;30899004;34428180;37828378;9637690", "class_list": "glycogene", "function": "Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (PubMed:11331020, PubMed:11457822). Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (PubMed:9637690)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88464;Q3TNP7;Q9JLK2", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0004394 heparan sulfate 2-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0010467 gene expression;GO:0030202 heparin proteoglycan metabolic process;GO:0060676 ureteric bud formation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8R3H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84075-1", "uniprot_id": "HPCA_MOUSE", "mass": 22427.0, "length": 193, "protein_name": "Neuron-specific calcium-binding protein hippocalcin", "gene_name": "Hpca", "organism": "Mouse", "refseq_name": "neuron-specific calcium-binding protein hippocalcin isoform 1", "refseq_ac": "NP_001123891", "gene_names_uniprotkb": "Hpca", "gene_names_refseq": "Hpca", "protein_names_uniprotkb": "Neuron-specific calcium-binding protein hippocalcin", "protein_names_refseq": "neuron-specific calcium-binding protein hippocalcin isoform 1; neuron-specific calcium-binding protein hippocalcin", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); torsion dystonia 2 (Disease Ontology:DOID:0090038); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:15444)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11978849;15607944;21750661;34203471;9931466", "class_list": "", "function": "An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging., [RefSeq, PubMed]; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7R4;P32076;P41211;P70510", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0031283 negative regulation of guanylate cyclase activity;GO:0071277 cellular response to calcium ion;GO:0009966 regulation of signal transduction;GO:0090314 positive regulation of protein targeting to membrane;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P84075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGZ1-1", "uniprot_id": "HPCL4_MOUSE", "mass": 22215.0, "length": 191, "protein_name": "Hippocalcin-like protein 4", "gene_name": "Hpcal4", "organism": "Mouse", "refseq_name": "hippocalcin-like protein 4", "refseq_ac": "NP_778163", "gene_names_uniprotkb": "Hpcal4", "gene_names_refseq": "Hpcal4; NVP-2", "protein_names_uniprotkb": "Hippocalcin-like protein 4; NVP-2; Neural visinin-like protein 2", "protein_names_refseq": "hippocalcin-like protein 4; neural visinin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:170638)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32015563;33300544", "class_list": "", "function": "May be involved in the calcium-dependent regulation of rhodopsin phosphorylation., [UniProtKB, UniProtKB, UniProtKB]; These results indicate that the neural calcium sensor Hpcal4 likely makes a limited contribution to pain and itch processing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYQ5-1", "uniprot_id": "HPIP_MOUSE", "mass": 13359.0, "length": 120, "protein_name": "Host cell factor C1 regulator 1", "gene_name": "Hcfc1r1", "organism": "Mouse", "refseq_name": "host cell factor C1 regulator 1 isoform 1", "refseq_ac": "NP_861542", "gene_names_uniprotkb": "Hcfc1r1; Hpip", "gene_names_refseq": "HPIP; Hcfc1r1", "protein_names_uniprotkb": "Host cell factor C1 regulator 1; HCF-1 beta-propeller-interacting protein", "protein_names_refseq": "HCF-1 beta-propeller-interacting protein; host cell factor C1 regulator 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:353502)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CYQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35737-1", "uniprot_id": "HNRH1_MOUSE", "mass": 49199.0, "length": 449, "protein_name": "Heterogeneous nuclear ribonucleoprotein H", "gene_name": "Hnrnph1", "organism": "Mouse", "refseq_name": "heterogeneous nuclear ribonucleoprotein H isoform 2", "refseq_ac": "NP_067485", "gene_names_uniprotkb": "Hnrnph1; Hnrph1; Hnrph", "gene_names_refseq": "E430005G16Rik; Hnrnph1; Hnrnph; Hnrph1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein H; hnRNP H", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein H isoform 2; heterogeneous nuclear ribonucleoprotein H", "tax_id": 10090, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:59013); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;20173027;24129315;24788674;25428506;25605945;26495903;29187734;30084848;30779550;31219806;33300544;34203471;34428180;37463454;39627609", "class_list": "", "function": "A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1. Erratum:[J Clin Invest. 2024 Apr 15;134(8):e181331. doi: 10.1172/JCI181331. PMID: 38618962] Publication Status: Online-Only, [RefSeq, PubMed]; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0098761 cellular response to interleukin-7", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70394-1", "uniprot_id": "I27RA_MOUSE", "mass": 69093.0, "length": 623, "protein_name": "Interleukin-27 receptor subunit alpha", "gene_name": "Il27ra", "organism": "Mouse", "refseq_name": "interleukin-27 receptor subunit alpha isoform 1 precursor", "refseq_ac": "NP_057880", "gene_names_uniprotkb": "Il27ra; Tccr; Wsx1", "gene_names_refseq": "CRL1; IL-27R; Il27ra; Tccr; WSX-1; Wsx1; zcytor1", "protein_names_uniprotkb": "Interleukin-27 receptor subunit alpha; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; TCCR; Type I T-cell cytokine receptor; WSX-1", "protein_names_refseq": "IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1; interleukin-27 receptor subunit alpha isoform 1 precursor; interleukin-27 receptor subunit alpha; type I T-cell cytokine receptor", "tax_id": 10090, "disease": "systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (mmu:50931); (R-MMU-8984722); (R-MMU-9020956)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11057672;26495903;34203471;34428180;9600072", "class_list": "", "function": "Signal-transducing subunit for an heterodimeric cytokine composed of IL27/p28 and a soluble receptor EBI3. Heterodimerizes with IL6ST/GP130 to mediate signal transduction in response to the heterodimeric cytokine IL27/p28-EBI3. This signaling system acts through STAT3 and STAT1. Also acts as a signaling receptor as part of the humanin receptor complex; binding of MT-RNR2/humanin (HN) activates the intracellular JAK-STAT3 signaling pathway leading to neuroprotection (By similarity). Involved in the regulation of Th1-type immune responses (PubMed:11057672). Also appears to be involved in innate defense mechanisms (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E9QNY4", "ec_number_list": "", "go_molecular_function": "GO:0045509 interleukin-27 receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:2000317 negative regulation of T-helper 17 type immune response;GO:0032700 negative regulation of interleukin-17 production;GO:0048302 regulation of isotype switching to IgG isotypes;GO:0050830 defense response to Gram-positive bacterium;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70394-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88866-1", "uniprot_id": "HUNK_MOUSE", "mass": 79603.0, "length": 714, "protein_name": "Hormonally up-regulated neu tumor-associated kinase", "gene_name": "Hunk", "organism": "Mouse", "refseq_name": "hormonally up-regulated neu tumor-associated kinase", "refseq_ac": "NP_056570", "gene_names_uniprotkb": "Hunk; Makv", "gene_names_refseq": "Bstk1; Hunk; Mak-v", "protein_names_uniprotkb": "Hormonally up-regulated neu tumor-associated kinase; 2.7.11.1; Serine/threonine-protein kinase MAK-V", "protein_names_refseq": "hormonally up-regulated neu tumor-associated kinase; serine/threonine-protein kinase MAK-V", "tax_id": 10090, "disease": "", "pathway": " (mmu:26559)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10662544;25605945;25881306;31219806;34428180;38846083;9273061", "class_list": "", "function": "HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Hunk has a role in normal intestinal proliferation and homeostasis and, although it does not alter overall survival rates, activity of this kinase does impact on tumour initiation rates during the early stages in tumourigenesis in the small intestine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09065-1", "uniprot_id": "HME1_MOUSE", "mass": 40981.0, "length": 401, "protein_name": "Homeobox protein engrailed-1", "gene_name": "En1", "organism": "Mouse", "refseq_name": "homeobox protein engrailed-1", "refseq_ac": "NP_034263", "gene_names_uniprotkb": "En1; En-1", "gene_names_refseq": "En-1; En1; Mo-en.1; engrailed-1", "protein_names_uniprotkb": "Homeobox protein engrailed-1; Homeobox protein en-1; Mo-En-1", "protein_names_refseq": "homeobox protein en-1; homeobox protein engrailed-1; mo-En-1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:13798)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1363401;1980115;2416459;2892757;31219806;8684466", "class_list": "", "function": "Required for proper formation of the apical ectodermal ridge and correct dorsal-ventral patterning in the limb., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USF7", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09065-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09066-1", "uniprot_id": "HME2_MOUSE", "mass": 33817.0, "length": 324, "protein_name": "Homeobox protein engrailed-2", "gene_name": "En2", "organism": "Mouse", "refseq_name": "homeobox protein engrailed-2 isoform 1", "refseq_ac": "NP_034264", "gene_names_uniprotkb": "En2; En-2", "gene_names_refseq": "En-2; En2; mo-En-2", "protein_names_uniprotkb": "Homeobox protein engrailed-2; Homeobox protein en-2; Mo-En-2", "protein_names_refseq": "homeobox protein en-2; homeobox protein engrailed-2 isoform 1; homeobox protein engrailed-2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:13799)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1363401;21540332;25428506;2892757;38009365;38537894", "class_list": "", "function": "Alterations of Perineuronal Net Expression and Abnormal Social Behavior and Whisker-dependent Texture Discrimination in Mice Lacking the Autism Candidate Gene Engrailed 2., [RefSeq, PubMed]; Glial cells are affected more than interneurons by the loss of Engrailed 2 gene in the mouse cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation;GO:0030902 hindbrain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14901-1", "uniprot_id": "HMOX1_MOUSE", "mass": 32929.0, "length": 289, "protein_name": "Heme oxygenase 1", "gene_name": "Hmox1", "organism": "Mouse", "refseq_name": "heme oxygenase 1", "refseq_ac": "NP_034572", "gene_names_uniprotkb": "Hmox1", "gene_names_refseq": "D8Wsu38e; HO-1; HO1; Hemox; Hmox1; Hmox; Hsp32", "protein_names_uniprotkb": "Heme oxygenase 1; 1.14.14.18; HO-1; P32 protein", "protein_names_refseq": "P32 protein; heme oxygenase (decycling) 1; heme oxygenase 1; hemoxygenase", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); Parkinsonism (Disease Ontology:DOID:0080855); berylliosis (Disease Ontology:DOID:10322); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); malaria (Disease Ontology:DOID:12365); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Sjogren's syndrome (Disease Ontology:DOID:12894); intracranial vasospasm (Disease Ontology:DOID:13100); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); pneumothorax (Disease Ontology:DOID:1673); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); hemochromatosis (Disease Ontology:DOID:2352); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); coronary restenosis (Disease Ontology:DOID:4247); brain edema (Disease Ontology:DOID:4724); esophageal cancer (Disease Ontology:DOID:5041); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (mmu:15368); (R-MMU-189483); (R-MMU-917937); (R-MMU-9609523); (R-MMU-9707564); (R-MMU-9707587)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "18400743;18474359;19224205;20173027;22872234;25428506;26495903;28528544;30084848;31599954;32973183;3409220;34428180;35820727;8288554", "class_list": "", "function": "Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (By similarity) Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.18;1.2.1.3;1.2.1.94;2.7.10.2;2.3.2.23;3.4.23.-", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904550 response to arachidonate;GO:0002246 wound healing involved in inflammatory response;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P14901-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35385-1", "uniprot_id": "HSPB7_MOUSE", "mass": 18635.0, "length": 169, "protein_name": "Heat shock protein beta-7", "gene_name": "Hspb7", "organism": "Mouse", "refseq_name": "heat shock protein beta-7", "refseq_ac": "NP_038896", "gene_names_uniprotkb": "Hspb7; Cvhsp; Hsp25-2", "gene_names_refseq": "27kDa; Hsp25-2; Hspb7; cvHsp", "protein_names_uniprotkb": "Heat shock protein beta-7; Cardiovascular heat shock protein; Heat shock protein 25 kDa 2; HspB7; Protein p19/6.8; cvHsp", "protein_names_refseq": "cardiovascular heat shock protein; heat shock 27kDa protein family, member 7 (cardiovascular); heat shock protein 25 kDa 2 (cardiovascular); heat shock protein beta-7; heat shock protein family, member 7 (cardiovascular); protein p19/6.8", "tax_id": 10090, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:29818)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10593960;27632998;28827800;29078393;36288343;37507081", "class_list": "", "function": "Our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart. Publication Status: Online-Only, [RefSeq, PubMed]; The authors found that deleting HSPB7 resulted in uncontrolled elongation of actin filaments and the formation of atypical actin filament bundles in cardiomyocytes., [RefSeq, PubMed]; These data indicate that MEF2 and AP-1 confer antagonistic regulation of Hspb7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FW72;Q8CDI0;Q9QUS2", "ec_number_list": "", "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35428-1", "uniprot_id": "HES1_MOUSE", "mass": 29749.0, "length": 282, "protein_name": "Transcription factor HES-1", "gene_name": "Hes1", "organism": "Mouse", "refseq_name": "transcription factor HES-1 isoform 1", "refseq_ac": "NP_032261", "gene_names_uniprotkb": "Hes1; Hes-1", "gene_names_refseq": "Hes1; Hry; bHLHb39", "protein_names_uniprotkb": "Transcription factor HES-1; Hairy and enhancer of split 1", "protein_names_refseq": "hairy and enhancer of split 1; transcription factor HES-1 isoform 1; transcription factor HES-1", "tax_id": 10090, "disease": "brain cancer (Disease Ontology:DOID:1319); epilepsy (Disease Ontology:DOID:1826); hemangiopericytoma (Disease Ontology:DOID:264); acute kidney failure (Disease Ontology:DOID:3021); central nervous system cancer (Disease Ontology:DOID:3620); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (mmu:15205)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10851137;34428180;7906273;9874198", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0043279 response to alkaloid;GO:1904010 response to Aroclor 1254;GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0021984 adenohypophysis development;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35428-1", "record_type": "protein" } ]